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2016 Vol. 23, No. 35 Published: 2016-12-18

	4	Influence of N-acetyl-seryl-aspartyl-lysyl-proline on transmembrane signal transduction of rat liver fibrosis model
		ZHANG Lei;LIU Hong-fu;WU Xiong-jian
		ObjectiveTo observe the effect of N-acetyl-seryl-aspartyl-lysyl-proline(AcSDKP)on rat liver fibrosis due to bile duct ligation (BDL),and to explore the relationship between this effect and TGF-β1-Smad2/3 and BMP-7-Smad1/5/8 signal channels.Methods30 SD rats were selected and randomly divided into the sham operation group,the model group and the treatment group(AcSDKP),BDL liver fibrosis model was built.when making model of the treatment group,subcutaneous micropump was implanted to provide AcSDKP treatment.On the 14thday,the rats were killed,then ELISA Enzyme linked immunosorbent assays were adopted to detect the hyaluronic acid(HA)and CollagenⅢ(PCⅢ) level,hydroxyproline(Hyp)measurement method was adopted to analyze the content of total collagen in hepatic tissue in a quantitative manner.Western blotting was adopted to detect the expression of transforming growth factor-β1(TGF-β1), bone morphogenetic protein-7(BMP-7),phosphorylation Smad2/3 and phosphorylation Smad1/5/8 protein in hepatic tissue.ResultsCompared with the sham operation group,the serum levels of HA,PCⅢ,and content of Hyp in hepatic tissue in the model group were increased(P＜0.05).The serum levels of HA,PCⅢ,and content of Hyp in hepatic tissue in the treatment group was significantly lower than that in the model group,with significant difference(P＜0.01).The expression of TGF-β1,phosphorylation Smad2/3 in the model group was higher than that in the sham operation group,with significant difference(P＜0.05).The expression of TGF-β1,phosphorylation Smad2/3 in the treatment group was lower than that in the model group,the expression of BMP-7 phosphorylation Smad1/5/8 in the treatment group was higher than that in the model group,with significant difference(P＜0.05).ConclusionAcSDKP has the effect of inhibiting BDL liver fibrosis in rats,which may be related to the inhibition of TGF-beta 1 pathway and activation of BMP-7 pathway.
		2016 Vol. 23 (35): 4-6转14 [Abstract] ( 182 ) HTML (46 KB) PDF (0 KB) ( 30 )

	7	Expression of ERCC1,β-tubulin 3 and TOPOⅡin advanced non-smallcell lung cancer and their relationship with clinical pathological features and efficacy of platinum based chemotherapy
		ZHANG Chun-jie;JIANG Wei-mei;HAN Lei;SUN Yong-mei
		ObjectiveTo explore the expressions of ERCC1,β-tubulin 3 and TOPOⅡin advanced non-small-cell lung cancer(NSCLC)and their correlations with clinical pathological features and efficacy of platinum based chemotherapy.Methods61 patients with NSCLC in our hospital from January 2012 to June 2013 were selected as the study subjects, mmunohistochemical method was used to detect the expression of tissue ERCC1 and β-tubulin 3 and TOPOⅡ,All the patientswere treated with Pemetrexed combined with Nedaplatin chemotherapy,and the efficacy was evaluated on a regular.ResultsThe express of ERCC1 and β-tubulin 3 was not related to the age,sex,clinical stage and histological type of the patient(P＞0.05).The expression of TOPOⅡwas not related to the age,sex,and clinical stage of the patients (P＞0.05).The positive expression of TOPOⅡin adenocarcinoma was 8 cases(22.86%),14 cases(53.85%)were positive in squamous cell carcinoma,and the positive expression of ERCC1,β-tubulin 3 and TOPOⅡ in squamous cell carcinoma was higher than that in adenocarcinoma,with significant difference(P=0.017).The positive expression of ERCC1, β-tubulin 3 and TOPOⅡwere 40.98%(25/61),47.54%(29/61)and 36.66%(22/61)respectively,the effective rate of positive expression of chemotherapy was 16.00%(4/25),48.28%(14/29)and 63.64%(14/22),the effective rate of negative expression of chemotherapy was 63.89%(23/36),40.63%(13/32)and 33.33%(13/39).ConclusionThe positive expression of ERCCI and TOPOⅡcan predict the efficacy of NSCLC in the treatment of platinum based chemotherapy drugs,and TOPOⅡhas important significance for the prognosis of advanced NSCLC with different histological types.
		2016 Vol. 23 (35): 7-10 [Abstract] ( 168 ) HTML (46 KB) PDF (0 KB) ( 31 )

	11	The application of simultaneous determination of Gastordine,Salidroside, Geniposide and Spinosin in“Gaishanshuimian Granules”by HPLC
		ZHANG Mei-ling;CHEN Yan-jie;ZHAO Ting;CHU Yin-ling;ZHANG Jie;FANG Yan;JIA De-xian
		ObjectiveTo establish an HPLC method for simultaneous determination of four constituents(Gastordine, Salidroside,Geniposide,Spinosin)in“GaishanshuimianGranules”.MethodsAforementionedfourmajorconstituentsin“Gaishanshuimian Granules”as the detecting subject.Column was Thermo Fisher Syncronis C18(250 mm×4.6 mm,5 μm).Mobile phase was acetonitrile-water,gradient elute,flow rate was 1.0 ml/min.Column temperature was maintained at 30℃, sample size was 10 μl.Detection wavelengths were set at 220,238,275 and 335 nm.ResultsLinear range of Gastordine, Salidroside,Geniposide,and Spinosin respectively were 0.8032-4.0160,0.5392-2.6960,2.6916-13.4580,0.2112-1.0560 μg. The RSD of precision,stability and repeatability test were all less than 2.00%.The average recoveries respectively were 98.17%,99.37%,98.84%and 99.27%with RSD of 0.67%,0.48%,0.49%and 0.93%,respectively.ConclusionThis developed HPLC method is reliable and convenient for simultaneous determination of Gastordine,Salidroside,Geniposide, and Spinosin,which could be applied to determine contents of four constituents and quality control of"Gaishanshuimian Granules".
		2016 Vol. 23 (35): 11-14 [Abstract] ( 183 ) HTML (45 KB) PDF (0 KB) ( 37 )

	15	Research on optimizing the extraction technique of Shanqibushenxiaoke Pills using orthogonal experiments
		CHEN Zhen-yao;1LIU Yan
		ObjectiveTo optimize the extraction technique of Shanqibushenxiaoke Pills.MethodsOrthogonal experimental design was used to optimize the extraction technique.The extraction rate of the Dipsacus saponinⅥand the recovery rate of total solids were used as observation indexes.To determine a more reasonable extraction technique,three factors which had greater influence on the extraction,including the amount of water used,the number of repetitions of extraction,and the extraction time were studied.According to the results of the orthogonal experiments,three pilot scale trials were performed to verify the feasibility of the extraction technique and the consistency of the product quality.Results The experimental result proved that the optimized extraction technique determined by using the orthogonal experiments was as follows:the Chinese herbal pieces was decocted with water and extracted for 2 times,each time with 8 times of water,extracted 2 hours in the first times,extracted 1.5 hours in the second times.ConclusionThe optimized extraction technique for the Shanqibushenxiaoke Pills was feasible and which was suitable for the large scale production.
		2016 Vol. 23 (35): 15-17转21 [Abstract] ( 164 ) HTML (48 KB) PDF (0 KB) ( 32 )

	18	Current situation of research on genetic engineering drugs
		HAN Rui-jie;WANG Xiao-hua;ZHANG Zhe;LI Gui-qin;LIU Hai-feng
		Fibrosis is the main cause of chronic organ failure,which is harmful to human beings.There still no effective drugs which can reverse fibrosis in clinic.Recently,with the research on pathogenesis of fibrosis and the development of molecular biological technology,genetic engineering drugs play an important role in anti-fibrosis therapy.
		2016 Vol. 23 (35): 18-21 [Abstract] ( 196 ) HTML (42 KB) PDF (0 KB) ( 33 )

	22	Research progress of the relationship between insulin resistance and cardio-cerebrovascular diseases
		LUO Xian-hu
		With the development of research about the pathogenesis of cardio-cerebrovascular diseases,more and more attention is paid to insulin resistance.Recently,the relationship between insulin resistance and cardio-cerebrovascular diseases has been a hot area in clinical research.It is helpful for the diagnosis,distinguishment of disease severity and treatment of cardio-cerebrovascular diseases.This review provides a update on progress about relationship between insulin resistance and cardio-cerebrovascular diseases.
		2016 Vol. 23 (35): 22-24 [Abstract] ( 152 ) HTML (38 KB) PDF (0 KB) ( 24 )

	25	Evaluation on cerebral hemodynamic changes before and after the nonsurgical treatment for patients with traumatic diffuse brain swelling under CT perfusion imaging
		ZHANG Ke;LIU Shao-guang;ZHANG Jian-hua;WEI Xiao-dong;ZHANG Dong-zhi
		ObjectiveTo study the application value of 64-slice spiral CT in the non-surgical treatment for patients with traumatic diffuse brain swelling.Methods100 patients with simple diffuse brain swelling were given non-surgical treatment in our hospital from June 2013 to May 2015,and they were selected and given CTP examination within 2 to 6 hours after injury,and CTP was reexamined after 7 days.The change of perfusion parameters in the region of interest before and after the treatment was analyzed.After 6 months patients were followed-up,the data was analyzed statistically with the clinical prognosis.ResultsAfter the non-surgical treatment,the CBF,CBV and MTT in the every region of interest were improved compared with those before treatment(P＜0.05).The patients with GOS score＞3 points were significantly improved.ConclusionCTP can reflect the cerebral hemodynamic changes in the patients with BDS rapidly and accurately,so as to provide reliable evidences for early treatment and determining the prognosis.
		2016 Vol. 23 (35): 25-27转36 [Abstract] ( 181 ) HTML (42 KB) PDF (0 KB) ( 28 )

	28	Study of influence of biphasic positive airway pressure ventilation on pulmonary artery hypertension in patients with overlap syndrome
		LI Yan-qun;LUO Fei;ZHANG Min
		ObjectiveTo explore the influence of biphasic positive airway pressure ventilation treatment on HIF-1α, ET-1,EPO and mPAP in patients with overlap syndrome.Methods80 cases with overlap syndrome treated from July 2013 to June 2016 were divided into the positive airway pressure ventilation group (n=42)and oxygen therapy group (n=38).Biphasic positive airway pressure ventilation method was given to the positive airway pressure ventilation group, while the oxygen therapy at night to the oxygen therapy group,30 healthy adults were selected as control group.The level change of serum HIF-1α,ET-1,EPO and mPAP were compared before and after the treatment between two groups.ResultsThe level of HIF-1α,ET-1,EPO and mPAP before therapy in the oxygen therapy group and the positive airway pressure ventilation group were all higher than those of the control group (P＜0.05),while there was no statistical difference between the positive eairway pressure ventilation group and oxygen therapy group (P＞0.05).The level of HIF-1α, ET-1,EPO and mPAP after treatment in two groups were obviously shorter than those before treatment(P＜0.05).The level of HIF-1α,ET-1,EPO and mPAP after treatment in the oxygen therapy group were all higher than those in the positive pressure ventilation group (P＜0.05).ConclusionBiphasic positive airway pressure ventilation can reduce the level of HIF-1α,ET-1,EPO and mPAP in patients with overlap syndrome effectively,and it can relieve pulmonary artery hypertension.and improve the hypoxia.
		2016 Vol. 23 (35): 28-30 [Abstract] ( 181 ) HTML (41 KB) PDF (0 KB) ( 32 )

	31	Application of limited open reduction and internal fixation combined with external fixation in complex distal tibial Pilon fracture
		ZHOU Zhao-cheng;GUO Jiu-sheng;HONG Tai-yang
		ObjectiveTo explore the application of limited open reduction and internal fixation combined with external fixation stent in complex distal tibial Pilon fracture.Methods90 cases with complex tibial distal Pilon fracture treated by our hospital from May 2013 to March 2014 were collected.According to the order of admission,they were divided into the observation group and the control group.The control group was treated by traditional open reduction and internal fixation,and the observation group was treated by limited internal fixation combined with external fixation stent.The therapeutic effect,the system score of functional recovery of the ankle joint(Muzur score)and the incidence of complications in two groups were observed.ResultsAfter treatment,the excellent and good rate in the observation group (86.67%)was significantly higher than that of the control group (64.44%)(P＜0.05).The incidence rate of complication in the observation group(4.44%)was significantly lower than that the control group(17.78%)(P＜0.05).ConclusionThe application effect of limited open reduction and internal fixation combined with external fixation stent in the complex tibial distal Pilon fracture is significant,which can reduce postoperative complications,and it is worthy of clinical promotion and application.
		2016 Vol. 23 (35): 31-33 [Abstract] ( 187 ) HTML (38 KB) PDF (0 KB) ( 39 )

	34	Effect of the new triple therapy of Evofloxacin combined with health education treating chronic atrophic gastritis with Hp-positive for quinquagenarian in community
		CHEN Qin-ming;Shao-bin;HUANG Li-hui;YU lian;CHEN Wei-ping;CHEN Hai-bin
		ObjectiveTo study the triple therapy of Evofloxacin combined with health education treating chronic atrophic gastritis with Hp-positive for quinquagenarian in community.Methods196 quinquagenarian patients with hronic atrophic gastritis with Hp-positive treated by our hospital from August 2015 to August 2016 were chosed and they were divided into observation group(n=98)and control group(n=98)according to of ID number.The control group was treated by standard triple therapy,while the observation group was treated by new triple therapy of Evofloxacin combined with health education.Clinical therapeutic effect,Hp eradication rate,healthy behavioral cognitive score and incidence rate of adverse reaction were compared between two groups.ResultsThe total effective rate of treatment and Hp eradication rate in observation group were higher than those of control group (P＜0.05).Each healthy behavioral cognitive scores of the observation group was higher than that of control group(P＜0.01).There was no significant difference of incidence rate of adverse reaction between two groups(P＞0.05).ConclusionThe new triple therapy of Evofloxacin combined with health education treating chronic atrophic gastritis with Hp-positive for quinquagenarian in community has a obvious effect,and it is safe and feasible,which can help to improve the ability of healthy behavioral cognitive in patients.It has a higher clinical promotion value.
		2016 Vol. 23 (35): 34-36 [Abstract] ( 134 ) HTML (38 KB) PDF (0 KB) ( 35 )

	37	Effect observation of Chemical Peel combined with Adapalene Gel for external use treating mild to moderate acne
		LU Fu-qiong;Zhen;YANG Fan
		ObjectiveTo investigate the clinical effect of Chemical Peel combined with Adapalene Gel for external use treating mild to moderate acne.Methods200 patients with mild to moderate acne treated by our hospital from May 2015 to May 2016 were selected as object.They were randomly divided into two groups,and each grroup had 100 cases. The observation group was treated by Chemical Peel combined with Adapalene Gel for external use,while the control group was treated by simple Adapalene Gel.Treatment effect between two groups was compared.ResultsThe total effective rate in patients of the observation group(97.0%)was higher than that of the control group(49.0%),and there was a statistical difference(P＜0.01).There was no statistical difference of lesion count for acne,papules and pustules and so on between two groups(P＞0.05),and lesion count for acne,papules and pustules and so on in the observation group was significantly lower than that of the control group(P＜0.05).All patients had no systemic adverse reactions.There was 2 cases respectively with skin lesion site in drug for exterior use having local redness and itching,tight feeling in the observation group and control group,then patients were asked to reduce the dosage of ointment to continue medication,and patients had no complaint.ConclusionChemical Peel combined with Adapalene Gel for external use treating mild to moderate acne not only can effectively improve the clinical symptom of patients,but also improve their overall quality of life.It is worthy of clinical promotion and application.
		2016 Vol. 23 (35): 37-39 [Abstract] ( 163 ) HTML (38 KB) PDF (0 KB) ( 31 )

	40	Effect of Pantoprazole on the prevention of stress ulcer following acute severe head injury
		QIN Hua-ping;MA Tao;YANG Chang-chun;ZHOU Jian-jun;SHI Yi-min
		ObjectiveTo explore the preventive effect of Pantoprazole injury complicated with stress ulcer in patients with acute severe traumatic brain.Methods162 patients with acute severe craniocerebral injury form January 2011 to December 2015 in our hospital were selected and divided into Cimetidine group and Pantoprazole group,81 cases in each group.Two groups of patients were given oxygen,dehydration of intracraninal pressure,control of blood pressure,nutrishing brain cell,prevention of infection maintain water and electrolyte balance and other support treatment,it is necessary to patients with indwelling gastric tube,continuous gastrointestinal decompression.The Cimetidine group was given cimetidine in prevention of stress ulcer on the basis of routine treatment,the Pantoprazole group was given Pantoprazole with the prevention of stress ulcer on the basis of routine treatment.The changes of gastric acid pH and the incidence of stress ulcer were analyzed and compared between the two groups.ResultsAfter treatment of Cimetidine group and Pantoprazole group were significantly compared with admission,the pH value of gastric juice increased,the difference was significant(P＜0.05),and the Pantoprazole group in the pH value of gastric juice before and after eating was more stable than that of Cimetidine group.Pantoprazole group of stress ulcer incidence compared with Cimetidine group decreased significantly (P＜0.05).ConclusionPantoprazole sustained inhibition of gastric acid secretion,increased acid pH,protect gastric mucosa,the incidence rate of injury can prevent stress ulcer complicated with acute severe traumatic brain.
		2016 Vol. 23 (35): 40-42 [Abstract] ( 133 ) HTML (39 KB) PDF (0 KB) ( 34 )

	43	Application of intra-aortic balloon pump in patients with acute myocardial infarction
		ZHANG Jing-wen;CHENG Wang-sheng
		ObjectiveTo investigate the clinical application and effect of intra-aortic balloon pump (IABP)in patients with acute myocardial infarction (AMI).MethodsAltogether 32 cases of patients diagnosed as AMI,admitted into our hospital from February 2013 to June 2015 and treated with IABP and percutaneous coronary intervention (PCI)were selected as study group.Another 30 patients with AMI who accepted routine treatment during the same period in our hospital were selected as control group.Changes of hemodynamics were observed before and after treatment in two groups,and the incidence of complications between two groups were compared and analyzed.ResultsHemodynamic changes in two groups were seen obviously(P＜0.05).Among which greater improvements occurred in study group than control group,there were no dead cases in the two groups intra-operatively.But 9 cases of post-operative complications happened in study group,during the period of hospitalization,6 cases of critical illnesses and 4 cases of deaths occurred post-operatively in study group.In contrast,16 cases of post-operative complications,11 cases of critical illnesses and 7 cases of deaths occurred in control group.ConclusionIABP in patients with AMI has achieved remarkable results with intra-operative safety,minor post-operative complications and lower mortality rate.
		2016 Vol. 23 (35): 43-45 [Abstract] ( 138 ) HTML (40 KB) PDF (0 KB) ( 31 )

	46	Risk factors analysis of ischemic stroke in elderly patients with atrial fibrillation
		LUO Fang-lin
		ObjectiveTo explore the risk factors of ischemic stroke in elderly patients with atrial fibrillation.MethodsThe clinical data of 132 cases of elderly patients with atrial fibrillation in our hospital from February 2013 to February 2015 were analyzed and whether or not with ischemic stroke diagnosed by combination of CT and MRI technology,patients were divided into control group(69 patients with atrial fibrillation alone)and observation group(63 cases of atrial fibrillation associated with ischemic stroke).Risk factors associated with ischemic stroke were analyzed.ResultsRisk factors of atrial fibrillation elderly patients with ischemic stroke were age(χ2=9.791,P=0.001),hypertension(χ2=4.859, P=0.027),type 2 diabetes (χ2=7.283,P=0.007),sustained atrial fibrillation (χ2=15.230,P=0.000),carotid artery plaque (χ2=8.508,P=0.004),left atrial expansion(χ2=8.340,P=0.004).Multivariate Logistic regression model analysis showed that age≥70 years old,hypertension,type 2 diabetes,sustained atrial fibrillation,carotid artery plaque and left atrial expansion were the independent risk factors for ischemic stroke occurrence in elderly patients with atrial fibrillation.ConclusionOlder age,hypertension,type 2 diabetes,sustained atrial fibrillation,carotid artery plaque and left atrial expansion are the risk factors of ischemic stroke in elderly patients with atrial fibrillation.
		2016 Vol. 23 (35): 46-48转51 [Abstract] ( 170 ) HTML (42 KB) PDF (0 KB) ( 35 )

	49	Effect of Bisoprolol combined with Enalapril and Spironolactone in the treatment of rheumatic heart disease patients with chronic heart failure
		XIE Guo-bo;ZHONG Yan-jia;SHENG Guo-tai;YU Mao-Sheng;YANG Ming
		ObjectiveTo observe and compare the efficacy of Bisoprolol and Enalapril combined with Spironolactone in the treatment of rheumatic heart disease patients with chronic heart failure.MethodsFrom June 2015 to June 2016,94 patients with rheumatic heart disease and chronic heart failure were selected as study objects and randomly divided into experimental group and control group,47 cases in each group.The patients in the control group were given routine drug treatment,while patients in the experimental group were treated with Bisoprolol and Enalapril combined with Spironolactone.The therapeutic effect of two groups were observed and compared.ResultsAfter treatment,the total effective rate in the experimental group was 95.75%(45/47),which was significantly higher than 82.98%(39/47)in the control group,and the difference was statistically significant(P＜0.05).The LVESD,LVEDD and LVEF of the experimental group was significantly better than that of the control group,and the difference was statistically significant(P＜0.05).ConclusionThe combination of Bisoprolol,Enalapril and Spironolactone is effective in the treatment of rheumatic heart disease with chronic heart failure.It is worthy to be further studied and applied.
		2016 Vol. 23 (35): 49-51 [Abstract] ( 168 ) HTML (38 KB) PDF (0 KB) ( 25 )

	52	Clinical study of induced embolization in the treatment of giant intracranial aneurysm
		ZHANG Zhen-yu;JIANG Qiu-hua;HUANG Jin-qing
		ObjectiveTo evaluate the clinical significance of induced embolization in the treatment of giant intracranial aneurysm(GIA).Methods20 patients undergoing interventional therapy in our hospital from January 2011 to July 2013 were enrolled in this study,which clinical data were obtained from 10 patients who underwent spring coil induced embolization and 10 cases were treated by occlusion of aneurysm.The results were followed up for 6-24 months,the results of immediate angiography and followed-up angiography were evaluated.ResultsAmong postoperative angiography,8 patients(80%)were completely occluded and 2 patients(20%)were most occluded in patients underwent spring coil induced embolization.Among postoperative angiography,6 cases(60%)were completely occluded,2 cases(20%)were most occluded and 2 cases(20%)were partially occluded in patients underwent occlusion of aneurysm.The followed-up angiography was performed that all patients were completely occluded among patients underwent spring coil induced embolization;7 patients with complete occlusion,1 with most occlusion and 2 with re-opening after stent-graft embolization treatment turned to complete occlusion among patients underwent occlusion of aneurysm.ConclusionThe results of angiography and followed-up angiography after spring coil induced embolization are better than those of occlusion of aneurysm.
		2016 Vol. 23 (35): 52-54 [Abstract] ( 142 ) HTML (37 KB) PDF (0 KB) ( 28 )

	55	Application and clinical applicability of different timing and surgical methods in the treatment of hypertensive intracerebral hemorrhage
		HUANG Jian
		ObjectiveTo study the clinical effect of different timing and surgical methods in the treatment of hypertensive intracerebral hemorrhage and analyze its applicability.MethodsFrom January 2012 to January 2016,301 patients with hypertensive intracerebral hemorrhage admitted into our hospital were selected as study objects and divided into three groups,super-early treatment group (＜6 h,n=81),early treatment group (6-24 h;n=156),and late treatment group(＞24 h;n=64)according to different timing (time from disease attack to hospitalization for treatment).Based on the bleeding position,amount of hemorrhage and degree of hematoma during the treatment,different surgical methods groups were selected,there were 92,121,and 88 cases in decompressive hematoma evacuation group,small bone window craniotomy group and puncture drainage group.The therapeutic effects in different time and surgical methods were compared.ResultsThe excellent rate in the supev-early treatment group,early treatment group and late treatment group was 77.8%,50.0%and 35.9%in a short term,and the rate of favorable prognosis during followed-up visits was 72.8%,56.4% and 31.2%,the rate in the super-early treatment group was superior to that in the early treatment group and the late treatment group,and the early treatment group was superior to that in the late treatment group with statistical difference (P＜0.05).The incidence of complications decompressive hematoma evacuation group,small bone window craniotomy group and puncture drainage group was 40.2%,24.8%,and 10.2%.The incidence of complications in the decompressive hematoma evacuation group was the highest,and the incidence in the puncture drainage group was the lowest with statistical difference after comparison(P＜0.05).The incidence of rehaemorrhagia in these three groups was 8.7%,7.4%,and 10.2%respectively,which was not displayed significant difference(P＞0.05).ConclusionFor patients meeting the surgical procedures,early implementation of surgical treatment can effectively improve neurological function and obtain a good prognosis.The selection of surgical methods should comprehensively consider patients′disease condition and physical state in order to decrease the incidence of complications and promote the quality of life in prognosis.
		2016 Vol. 23 (35): 55-58 [Abstract] ( 155 ) HTML (46 KB) PDF (0 KB) ( 42 )

	59	Clinical effect of Thymosin α1combined with CHOP regimen in the treatment of diffuse large B cell lymphoma and influence on bone marrow suppression and immune function
		JIANG Yi;ZUO Hong-bo;WANG Zhi
		ObjectiveTo explore the influence of Thymosin α1combined with CHOP regimen on effect,bone marrow suppression and immune function of diffuse large B cell lymphoma (DLBCL).Methods99 patients with DLBCL from January 2013 to March 2016 in our hospital were selected and divided into the control group(49 cases)and the observation group (50 cases)according to the random number table method.The control group was treated with CHOP chemotherapy,while the observation group was treated with Thymosin α1on the basis of the control group.The level of peripheral blood T cell subsets and bone marrow suppression in the two groups before and after treatment were compared and the treatment effect was compared.ResultsThe level of CD4,NK after chemotherapy in the observation group was higher than that before chemotherapy,with significant difference (P＜0.05).The level of CD4,CD4/CD8,NK after chemotherapy in the control group was lower than that before chemotherapy,with significant difference(P＜0.05).The improvement of immune function after chemotherapy in the observation group was better than that in the control group after chemotherapy,with significant difference (P＜0.05).There was no significant difference in the incidence rate of bone marrow suppression ofⅢ-Ⅳdegree between the two groups (P＞0.05).There was no significant difference in the total effective rate between the two groups(P＞0.05).ConclusionThymosin α1can significantly improve the cellular immune function in patients with DLBCL,but there is no advantage in improving curative effect and reducing the risk of bone marrow suppression.
		2016 Vol. 23 (35): 59-61 [Abstract] ( 173 ) HTML (41 KB) PDF (0 KB) ( 39 )

	61	Effect analysis of laparoscope partial gastric resection in the treatment of benign gastric tumor
		LIU Jie;NIE Hui;BAO Yu;NIE Ji-Shan
		ObjectiveTo explore the effect of laparoscopic partial gastric resection in the treatment of benign gastric tumor.Methods16 cases of benign gastric tumor underwent traditional open surgery from February 2008 to February 2010 in our hospital were selected as the control group,16 cases of benign gastric tumor underwent laparoscopic partial gastric resection from March 2010 to February 2015 were selected as the observation group.The amount of blood loss, operation time,postoperative recovery condition and the incidence rate of complication were compared between the two groups.ResultsThe recent effective rate,1 year survival rate of the observation group was higher than that in the control group,with significant difference (P＜0.05).Disease progression time of the observation group was(10.8±1.1)months, which was lower than(7.8±1.0)months of the control group,with significant difference(P＜0.05).The operation time,the amount of blood loss,recovery activity time and length of stay in the observation group was better than that in the control group,with significant difference (P＜0.05).There was no deaths in the two groups after operation.ConclusionThe application of laparoscopic partial gastric resection in the treatment of benign gastric tumor has a significant effect, which has the advantages of small trauma,short recovery time and low incidence of complications,it is worthy of clinical promotion and application.
		2016 Vol. 23 (35): 61-64 [Abstract] ( 155 ) HTML (37 KB) PDF (0 KB) ( 33 )

	65	Effects of the neoadjuvant chemotherapy of the combination application of Epirubicin and Lipid Paclitaxel in the treatment of triple negative breast cancer
		WEI Wen-song
		ObjectiveTo explore the clinical efficacy of the neoadjuvant chemotherapy of the combination application of Epirubicin and Lipid Paclitaxel in the treatment of triple negative breast cancer (TNBC).Methods80 patients with TNBC in our hospital from June 2015 to June 2016 were selected and randomly divided into the observation group and the control group,40 cases in each group.The control group was given simple neoadjuvant chemotherapy of Epirubicin. The observation group was given neoadjuvant chemotherapy of the combination application of Epirubicin and Lipid Paclitaxel.The tumor diameter,breast cancer susceptibility gene(BRCA1)level,fork-box protein A1(FOXA1)level before and after treatment and clinical efficacy,the incidence rate of adverse reaction were compared between the two groups.ResultsThe total effective rate of the observation group was 82.50%,which was higher than 70.00%of the control group,with significant difference (P＜0.05).There was no significant difference in the incidence rate of adverse reaction between the two groups(P＞0.05).The tumor diameter,the level of BRCA1 and FOXA1 after treatment in the two group was lower than that before treatment,with significant difference (P＜0.05).The tumor diameter,the level of BRCA1 and FOXA1 after treatment in the observation group was better than that in the control group,with significant difference(P＜0.05).ConclusionThe neoadjuvant chemotherapy of the combination application of Epirubicin and Lipid Paclitaxel in the treatment of TNBC is safe and reliable,with no increase of adverse reaction,and the patients have a higher degree of tolerance while being treated.It is highly significant in clinical application.
		2016 Vol. 23 (35): 65-68 [Abstract] ( 137 ) HTML (45 KB) PDF (0 KB) ( 40 )

	69	Influence study of therapeutic effect and immune function of Kanglaite Injection combined with chemotherapy on the advanced non-small cell lung cancer
		ZHENG Wen;HUANG Kai-rong;RAO Min-chao
		ObjectiveTo explore the influence of therapeutic effect and immune function of Kanglaite Injection combined with chemotherapy on the advanced non-small cell lung cancer(NSCLC).Methods64 patients with advanced non-small cell lung cancer from June 2014 to June 2016 in our hospital were selected and randomly divided into the study group and the control group,32 cases in each group.The control group was treated with chemotherapy,and the study group was treated with Kanglaite Injection on the basis of the chemotherapy.The determination results of peripheral blood T lymphocyte subsets and peripheral blood immunoglobulin were compared between the two groups before and after treatment.ResultsThe levels of CD3+,CD4+and CD8+in the study group after treatment was higher than that in the control group after treatment,with significant difference(P＜0.05).The level of IgG in the study group after treatment was(9.71±0.35)mg/L,which was higher than(8.19±0.30)mg/L in the control group after treatment,with significant difference (P＜0.05).ConclusionKanglaite Injection combined with chemotherapy in the treatment of advanced non-small cell lung cancer can effectively improve immune function,it is worthy of clinical promotion and application.
		2016 Vol. 23 (35): 69-70转74 [Abstract] ( 152 ) HTML (38 KB) PDF (0 KB) ( 32 )

	71	Effect observation of Gongliuxiao combined with Methyltestosterone and Mifepristone in the treatment of perimenopausal uterine fibroid
		RAO Mei-hong
		ObjectiveTo observe the clinical efficacy of Gongliuxiao combined with Methyltestosterone and Mifepristone in treatment of perimenopausal uterine fibroid.MethodsNinety-four patients with perimenopausal uterine fibroid admitted into the People′s Hospital of Nanchang County from April 2013 to April 2015 were selected,and they were divided into two groups according to the random number table method,47 cases in each group.Control group was given the treatment of Methyltestosterone and Mifepristone,and observation group was given the Gongliuxiao on this basis of the treatment of the control group.The clinical efficacy and adverse reactions of the two groups were compared;the hormone levels such as progesterone (P),follicle-stimulating hormone (FSH),luteinizing hormone (LH),estradiol(E2),and the changes of uterus volume and myoma volume of the two groups before and after treatment were observed.ResultsThe total effective rate of the observation group was 91.49%,significantly higher than 74.47%of the control group,the difference was statistically significant(P＜0.05);before treatment,there was no significant difference in the progesterone levels,uterus volume and myoma volume between the two groups(P＞0.05);after treatment,the improvement situation of hormone levels of the observation group was significantly better than the control group,and the reduction degree of uterus volume and myoma volume was significantly larger than that of the control group(P＜0.05);there was no statistically significant difference in the adverse reactions between the two groups (P＞0.05).ConclusionGongliuxiao combined with Methyltestosterone and Mifepristone has definite clinical efficacy,it can effectively promote the shrinking of uterine fibroid,relieve clinical symptoms and has value of clinical application.
		2016 Vol. 23 (35): 71-74 [Abstract] ( 135 ) HTML (43 KB) PDF (0 KB) ( 38 )

	75	Influence of tubal ligation on breastfeeding
		ZHANG Hui-jie;LIU Guang-hua;WANG Cheng-yi;YE Hong;LIU Yan-bin;MIAO Chong;CHEN Lumin;CHEN Qi
		ObjectiveTo investigate the influence of tubal ligation on breastfeeding.Methods180 women underwent tubal ligation from July 2014 to June 2015 were selected.The physiological and psychological status of women before and after the operation were observed.The prolactin level was measured before and after the operation.The psychological status of the patients was scored by the self-rating anxiety scale and self-rating depression scale.The secretion volume and nutrient composition of breast milk in women before and after the surgery were detected.ResultsThe level of prolactin secretion in women after 1 month surgery was lower than that before surgery,and the difference was statistically significant(P＜0.05)and after 1 month surgery,the score of anxiety and depression scale after the surgery was higher than that before surgery,and the difference was statistically significant(P＜0.05).After 2 months surgery,the above-mentioned indices were resumed to normal.After 1 month surgery,the secretion volume of breast milk in women reduced compared with before surgery,but there was no statistically significant difference (P＞0.05)and after 2 months surgery, the index was resumed to normal.There was no statistically significant difference of the secretion volume of breast milk before and after surgery (P＞0.05).ConclusionTubal ligation has a temporary effect on women′s physiology and psychology,but it will recover gradually with time.It does not affect women′s health and breastfeeding.
		2016 Vol. 23 (35): 75-77转83 [Abstract] ( 157 ) HTML (44 KB) PDF (0 KB) ( 35 )

	78	Clinical observation of benign ovarian neoplasms treated by vaginal ovarian cyst
		ZHONG Ling
		ObjectiveTo investigate the effect of vaginal ovarian cyst removal on benign ovarian tumors.MethodsEighty patients with benign ovarian tumors admitted in Ruijin People′s Hospital from June 2014 to September 2015 were double-blind randomly divided into two groups,with 40 cases in each group.Observation group and control group were treated by vaginal ovarian cystectomy，laparoscopic ovarian cystectomy treatment respectively，and the clinical results of the two groups were compared.ResultsThere was no significant difference in the operation time，intraoperative blood loss and complication between the two groups （P＞0.05）.There were significant differences in the postoperative analgesic use，postoperative first ventilatory time，ambulation time and length of hospital stay between the two groups （P＜0.05）.ConclusionOvarian cyst and laparoscopic ovarian cyst ablation for benign ovarian cysts do not produce great trauma，which will help the patients recover early.However，the former can achieve the effect without scars and less postoperative analgesic drugs.
		2016 Vol. 23 (35): 78-80 [Abstract] ( 138 ) HTML (38 KB) PDF (0 KB) ( 28 )

	81	Analysis of application values of CRP in gynecological infectious diseases
		ZHANG Huan-qin;WANG Xian-min;MAI Xi-xian
		ObjectiveTo explore the differential diagnostic value of CRP in gynecological infections diseases.MethodsEighty-two patients with infectious diseases of gynecologic in our hospital from August 2015 to August 2016 were selected as the experimental group,while 20 healthy women were collected as the control group.All subjects were tested for CRP and WBC.ResultsThere were significant differences in CRP of patients with inflammation,cervicitis,urethritis, endometritis and vaginitisof between the experimental group and the control group (P＜0.05).There were significant differences in WBC of patients with inflammation,urethritis,and endometritis between the experimental group and the control group (P＜0.05),but the WBC values of the cervicitis and vaginitis had no significant difference with the control group(P＞0.05).The total positive rate of CRP detection(92.7%)in gynecological infections was significantly higher than the total positive rate of WBC detection(61.2%)(P＜0.01).ConclusionThe rate of CRP detection is significantly higher than the WBC detection,can be used as gynecological infectious diseases routine diagnostic methods to assist clinical screening,which was worthy of clinical application.
		2016 Vol. 23 (35): 81-83 [Abstract] ( 142 ) HTML (36 KB) PDF (0 KB) ( 36 )

	87	The influence of uterine artery block combined with myomectomy under laparoscope on the ovarian function and reproductive function of patients with uterine fibroid
		DAI Jin-cheng
		ObjectiveTo study the influence of laparoscopic uterine artery block jcombined with myomectomy on the ovarian function and reproductive function of patients with uterine fibroid.Methods82 patients diagnosed uterine fibroid and given laparoscopic treatment by our hospital from June 2013 to August 2015 were admitted into the study and they were divided into two groups.Two groups were given myomectomy,and the control group was not treated with the uterine artery block,while the observation group accepted the uterine artery block before resecting the fibroid.The curative effect of operation between was compared.ResultsCompared with the control group,the operation time and postoperative exhaust of the observation group were shorter with less intraoperative blood loss(P＜0.05).The observation group with estradiol(E2),follicle hormone(FSH)level were lower than those of control group(P＜0.05),but those of the two groups after 6 months had no difference (P＞0.05).Myoma recurrence rate of after 6 months and 1 year operation in the observation group was lower than that of the control group (P＜0.05).Postoperative pregnancy rate of 1 year between two groups had no significant difference(P＞0.05).ConclusionThe trauma of uterine artery block combined with myomectomy under laparoscope is small,the recurrence rate is low and will not affect ovarian and reproductive function,and it is worthy of promotion.
		2016 Vol. 23 (35): 87-89转92 [Abstract] ( 141 ) HTML (42 KB) PDF (0 KB) ( 32 )

	90	Observation of the application of serum calcitonin original and C-reactive protein in the condition assessment of children with community-acquired pneumonia
		LONG Chun-gen
		ObjectiveTo study the application value of level determine of serum calcitonin original and C-reactive protein(CRP)in the evaluate of community-acquired pneumonia disease.MethodsFifty children with bacterial community acquired pneumonia and 50 children viral with community-acquired pneumonia diagnosed and treated in our hospital from April 2014 to April 2016 were selected,while 50 healthy people with the same age at the same period in our hospital accepted physical examination were selected,they were defined as the study group 1,study group 2 and control group.Levels of serum calcitonin original and CRP of the three groups were determined by enzyme-linked immune turbidimetric method,and the test results of three groups of several indicators and number of test results positive were compared.ResultsLevels of serum calcitonin original and CRP of study 1 group were significantly higher than those of the study 2 group and the control group,the differences were statistically significant(P＜0.05);levels of serum calcitonin original and CRP were significantly higher than those of the control group,the differences were statistically significant (P＜0.05).ConclusionLevels of serum calcitonin and CRP have certain clinical value in severity evaluation of children with community-acquired pneumonia disease.
		2016 Vol. 23 (35): 90-92 [Abstract] ( 146 ) HTML (36 KB) PDF (0 KB) ( 36 )

	93	Detection and meaning of food intolerance in recurrent respiratory tract infection children patients in outpatient
		YU Xiang;LUO Jia;CHEN Qi-wei;QU Hua;REN Ling
		ObjectiveTo explore the detection results and meaning for 14 kinds of food intolerance of recurrent respiratory tract infection children patients in outpatient and to provide new laboratory reference for etiological diagnosis,prevention and treatment for recurrent respiratory tract infection.Methods72 children with recurrent respiratory tract infection treated by pediatric outpatient in our hospital from September 2013 to September 2014 were selected and were selected as experimental group.90 healthy children from child health clinic of our hospital were selected as control group.14 kinds of food intolerance detection (food allergen specific IgG antibody)were conducted in two groups and statistical analysis was conducted.Diet control and regular follow up were adopted according to examination results.The improvement situation of recurrent respiratory tract infection morbidity after diet control was observed.ResultsThe total positive rate of serum food specific IgG antibody in experimental group (63.9%)was higher than that in health control group(32.2%)and the difference between two groups was statistical significance(P＜0.01).In the experimental group,46 cases of food specific IgG positive children were followed up for one year after diet control,there was no recurrent respiratory infection occurred in 29 children.ConclusionOutpatient recurrent respiratory tract infection has relationship with food intolerance.Diet control can decrease the morbidity of recurrent respiratory tract infection.Food intolerance detection has positive clinical value in prevention and treatment of recurrent respiratory tract infection in children.
		2016 Vol. 23 (35): 93-95转104 [Abstract] ( 116 ) HTML (41 KB) PDF (0 KB) ( 36 )

	96	Effect analysis of Salbutamol combining with Pulmicort Respules in the treatment of children with acute episoded asthma
		LI Fei;WU Jing;FU Bao-fang
		ObjectiveTo explore and analyze the therapeutic value of Salbutamol combining with Pulmicort Respules in the treatment of children with acute asthma.MethodsA total of 90 children with acute attack of asthma in Enping Maternal and Child Health Hospital of Guangdong Province from January 2014 to January 2016 were selected and divided into two groups according to the random number table,with 45 cases in each group.Patients in the control group were treated with routine therapy.In the research group,on the basis of the control group,Salbutamol together with Pulmicort Respules was added.The therapeutic effect in the two groups was analyzed.ResultsThe total clinical effective rate in the research group was 97.78%,with a significant difference compared with that in the control group accounting for 82.22%(P＜0.05).In the research group,disappearing time of shortage of breath,cough,panting,and rale was(3.92±1.56), (8.42±1.36),(4.78±1.35),and (7.68±1.65)d,respectively,which was displayed a statistically significant difference compared with those in the control group[(2.26±0.63),(6.24±1.03),(2.27±1.01),and(5.36±1.04)d](P＜0.05).The treatment satisfaction from children′s parents was 95.56%,with a statistically significant difference in comparison with that in the control group(80.00%)(P＜0.05).ConclusionApplication of Salbutamol combining with Pulmicort Respules can obtain a favorable effect on treating children with acute asthma.
		2016 Vol. 23 (35): 96-98 [Abstract] ( 117 ) HTML (37 KB) PDF (0 KB) ( 35 )

	99	Clinical study of lymphocyte injection combined with oral administration of progesterone in the treatment of alloimmune recurrent abortion
		LONG Cheng-ying;XU Shan-shan
		ObjectiveTo study the clinical effect of lymphocyte injection combined with oral administration of progesterone in the treatment of alloimmune recurrent abortion.MethodsTwo hundred patients were randomly selected from January 2015 to January 2016 in our hospital with negative closed antibodies for recurrent abortion and the same kind of immunity,and were randomly divided into the control group and the study group equally.The patients of the study group was given the injection of lymphocyte and when pregnancy for progesterone plus;the patients of the control group, pregnancy was given lymphocyte injection combined with oral dydrogesterone.At the same time,patients of the two groups were regularly followed up to observe with pregnancy success rate and pathological pregnancy rate.ResultsAfter the corresponding treatment,patients with the positive situation of the two groups was more obvious,but the difference between the positive and negative cases was not significant(P＞0.05).Patients with greater or equal to 12 weeks pregnancy were successful,the success rate of pregnancy of the study group(80.0%)was significantly higher than that of the control group (62.0%),the difference was statistically significant(χ2=17.267,P=0.018).ConclusionThe preinjection of lymphocytes,pregnancy plus oral dydrogesterone in the treatment of patients with alloimmune recurrent spontaneous abortion,improve the cell immune status in vivo,has good curative effect.
		2016 Vol. 23 (35): 99-101 [Abstract] ( 128 ) HTML (35 KB) PDF (0 KB) ( 33 )

	102	Analysis of clinical effect of Phloroglucin for injection in promoting cervical softening in labor
		WU Mei-yu;ZHU Fei-yin
		ObjectiveTo explore the clinical effect of Phloroglucin for injection in promoting cervical softening in labor.Methods58 puerperae with vaginal delivery admitted into our hospital from March 2015 to April 2016 were selected as research subject.They were assigned to the observation group and the control group according to the simple randomization method,and there were 29 patients in each group.The control group was given Oxytocin,and the observation group was given Oxytocin combined with Phloroglucinol.The maternal cervical maturity,time of delivery,total amount of postpartum hemorrhage and incidence rate of complication were compared between two groups.ResultsAfter treatment, the Bishop cervical maturity score in the observation group was significantly higher than that before treatment and that in the control group,and the latency period and the active period were shorter than those in the control group (P＜0.05). There were no significant difference in the second stage of labor,the third stage of labor,the total amount of postpartum hemorrhage (P＞0.05).The incidence rate of complication in the observation group was lower than that of the control group(χ2=6.72,P=0.01).ConclusionPhloroglucinol for injection can promote the cervix softening,which can shorten the first stage of labor and reduce the amount of postpartum hemorrhage and the incidence rate of complication.
		2016 Vol. 23 (35): 102-104 [Abstract] ( 160 ) HTML (38 KB) PDF (0 KB) ( 35 )

	105	Analysis of the application of Mifepristone in the treatment of uterine myoma after myomectomy
		CUI Nan
		ObjectiveTo discuss and analyze the application of Mifepristone in the treatment of uterine myoma after myomectomy.Methods168 patients with hysteromyoma from May 2013 to December 2015 in our hospital were selected as the research subject,and they were divided into group A (84 cases)and group B (n=84)according to the operation sequence,patients of the two groups were given routine therapy and nursing,patients of the group A were treated with Mifepristone in addition.Progesterone levels,adverse reaction and recurrence of patients were compared between the two groups.ResultsLevels of follicle-stimulating hormone,estradiol and progesterone of patients in group A were better than those of the group B,the differences of statistical significance(t=12.366,19.730,18.944,P=0.000,0.000,0.000).The overall incidence of adverse reaction in the group A was lower than that of the group B,the difference of statistical significance (χ2=5.929,P=0.015);the recurrence rate of patients in the group A was lower than that of the group B,the difference of statistical significance (χ2=8.974,P=0.003).ConclusionApplication of Mifepristone after myomectomy has obvious effect,it effectively improve the level of progesterone,reduce the adverse reactions,and reduce the recurrence,worthy of clinical application.
		2016 Vol. 23 (35): 105-107 [Abstract] ( 128 ) HTML (37 KB) PDF (0 KB) ( 33 )

	108	Feasibility research on Fuke Zaizao Capsules as an adjuvant therapy in the treatment of polycystic ovary syndrome
		LI Xiao-fang
		ObjectiveTo observe the effect of Fuke Zaizao Capsules as an adjuvant therapy in the treatment of polycystic ovary syndrome(PCOS).MethodsFrom December 2010 to December 2015,500 patients with PCOS were evenly divided into the research group(n=250)and control group(n=250)in random.In the research group,Fuke Zaizao Capsules combined with Ethinylestradiol and Cyproterone Acetate Tablets was adopted,while in the control group,simple Ethinylestradiol and Cyproterone Acetate Tablets was used.The therapeutic effect and the level of serum follicle-stimulating hormone(FSH),luteinizing hormone(LH)and testosterone(T)before and after treatment between two groups were compared.ResultsThe total effective rate was 94.0%in the research group and 87.2%in the control group respectively. The total effective rate in the research group was significantly higher than that in the control group (P＜0.05).Before therapy,there was no significant difference in serum FSH,T,or LH level after comparisons between two groups(P＞0.05). After treatment,FSH,T and LH level in the two groups were significantly decreased (P＜0.05).After therapy,the value of FSH,T,and LH in the research group and control group were(3.8±0.6)mIU/ml and(4.4±0.7)mIU/ml,(0.5±0.2)μg/L and (1.0±0.4)μg/L,and(6.6±1.1)mIU/ml and(8.7±1.6)mIU/ml in turn,after comparison,the level in the research group were all lower than those in the control group (P＜0.01).ConclusionFuke Zaizao Capsules combined with Ethinylestradiol and Cyproterone Acetate Tablets can obtain a remarkable effect treating PCOS and greatly improve the metabolism of sex hormones,and can be widely used in clinical practice.
		2016 Vol. 23 (35): 108-110 [Abstract] ( 146 ) HTML (36 KB) PDF (0 KB) ( 3 )

	111	Effect of nasal irrigation time on the removal of secretions from lower respiratory tract infection in infants
		SHAO Xia;LIU Wei-juan;LIU Li-xing;YANG Pei-shan;YAO Yi;WANG De-hua;LIU Li-juan
		ObjectiveTo investigate the effect of different nasal irrigation time on the clearance of secretions in infants with lower respiratory tract infection after 3%hypertonic saline solution atomization.MethodsFrom October 2014 to January 2015,180 children with lower respiratory tract infections in the First Affiliated Hospital of Guangzhou Medical University were selected in randomized controlled and single blind method.Children were randomly divided into two groups，and each group had 90 cases.Children of the two groups were all given the treatment of sanlian atomization combined atomization of 3%hypertonic saline,in the observation group，the nasal irrigation was used in 10 min after the atomization，while in the control group，the nasal irrigation was used in 30 min after atomization.The clinical symptoms，signs improving time and length of hospital stay，sleep quality were compared between the two groups.ResultsThe time of asthmatoid dyspnea，paroxysmal cough disappeared，rales，lung phlegm Ming sound disappear，hospital stay were shorter in the observation group than that of control group,the difference had statistical significance （P＜0.05）.Sleep quality of children in observation group was better than that of control group,the difference of two was statistically significant（P＜0.05）.Conclusion10 minutes after atomization，nasal irrigation can relieve the clinical symptoms and signs of the patients with lower respiratory tract infection more quickly,has better effect,it is worthy of clinical application.
		2016 Vol. 23 (35): 111-113 [Abstract] ( 149 ) HTML (40 KB) PDF (0 KB) ( 29 )

	114	Application value of color Doppler ultrasound and magnetic resonance imaging in the diagnosis of breast cancer
		YANG Di;GUO Shun-lin;LI Yi-ping;XIE Yao
		ObjectiveTo explore the application value of color Doppler ultrasound (CDUS)and magnetic resonance imaging (MRI)in the diagnosis of breast cancer.MethodsThe clinical data of 130 patients with breast diseases admitted to our hospital from June 2014 to May 2016 were collected.Control pathological examination results,the diagnostic accuracy of breast cancer and mass,Mao Cizheng,calcification of CDUS elastography and 3.0 T MRI were compared.ResultsThe diagnostic accuracy of MRI for benign and malignant breast lesions was 73.3%and 67.4%,respectively.The diagnostic accuracy of CDUS elastography in benign and malignant breast lesions was 74.6%and 75.6%,respectively, with a certain rate of missed diagnosis.CDUS elastic imaging was sensitive to the masses,but it was not sensitive to calcification and Mao Cizheng.MRI had high sensitivity to burr sign and mass,but had low sensitivity to calcification.There were own advantages and disadvantages in the two separate applications.CDUS elastography combined with MRI could further improve the detection rate of breast cancer patients,Mao Cizheng and calcification (χ2=10.736,3.125,22.428,P＜0.05).ConclusionCDUS elastography and MRI alone for the diagnosis of breast cancer have a certain rate of missed diagnosis and misdiagnosis,but after the combination of the two methods,the rate of diagnosis of breast mass,Mao Cizheng and calcification are significantly increased,it can provide reference for early diagnosis of breast cancer.
		2016 Vol. 23 (35): 114-116转119 [Abstract] ( 149 ) HTML (42 KB) PDF (0 KB) ( 33 )

	117	Comparison of application value of transvaginal and abdominal color Doppler ultrasonography in ectopic pregnancy
		LIU-Min
		ObjectiveTo investigate the clinical application value of transvaginal and abdominal color Doppler ultrasonography in ectopic pregnancy.Methods80 cases of ectopic pregnancy in our hospital from January 2014 to May 2016 were selected and randomly divided into the observation group and the control group,40 cases in each group.The observation group was given transvaginal ultrasonography,and the control group was underwent with abdominal ultrasonography.The time-consuming before inspection,time-consuming inspection were compared between the two groups. The diagnostic rate of ectopic pregnancy and location distribution of ectopic pregnancy in the two groups were counted.ResultsThe time-consuming before inspection in the observation group was(1.9±0.4)minutes,which was shorter than (15.2±2.3)minutes in the control group,with significant difference (P＜0.01).The time-consuming inspection in the observation group was(8.1±0.3)minutes,which was shorter than (10.1±0.5)minutes in the control group,with significant difference(P＜0.01).The diagnostic rate of ectopic pregnancy in the observation group was 97.5%,which was higher than 75.0%in the control group,with significant difference (χ2=6.746，P=0.009).The occurrence site of ectopic pregnancy in the two groups,fallopian tube was the most common,which were more than 75.0%.ConclusionTransvaginal ultrasonography can diagnose the occurrence of ectopic pregnancy faster and more easily,especially for the patients with thick abdominal fat,so it has more clinical application advantage.
		2016 Vol. 23 (35): 117-119 [Abstract] ( 150 ) HTML (37 KB) PDF (0 KB) ( 33 )

	120	The curative effect comparison of oral mifepristone Intramuscular injection of methotrexate and combination for the treatment of unruptured ectopic pregnancy or abortion
		YANG Man
		ObjectiveTo explore the curative effect of oral mifepristone intramuscular injection of methotrexate and combination for the treatment of unruptured ectopic pregnancy or abortion.Methods120 cases of patients with pregnancy from January to December 2015 in our department of obstetrics and gynecology of hospital,were randomly divided into three groups.Patients in group A were treated with mifepristone,group B was treated with methotrexate,and group C was treated with methotrexate combined with mifepristone.The effect of 3 groups of termination of pregnancy and adverse drug reaction were compared.ResultsThe cure rate in group C was 93.3%,group B was 75.0%,the cure rate of group A was 70.0%,the differences were significant(P＜0.05).The average blood β-HCG recovery time,the disappearance time and length of stay in hospital were significantly shorter than the other two groups,the differences were significant(P＜0.05).The incidence of adverse reactions in the 3 groups were low,and there were no significant differences(P＞0.05).ConclusionOral mifepristone combined with methotrexate therapy in the treatment of non ruptured or non abortion ectopic pregnancy has good curative effect,high cure rate,better than one,it is worthy of clinical application.
		2016 Vol. 23 (35): 120-122 [Abstract] ( 124 ) HTML (34 KB) PDF (0 KB) ( 37 )

	123	To stand on granular functional gastroduodenal disease clinical curative effect observation
		LIU Ren-peng
		ObjectiveTo observe the Dalitong granule in the treatment of functional gastroduodenal disease clinical curative effect.Methods67 patients of stomach and duodenum of different treatment regimens in the treatment of from February 2014 to October 2015 were selected as the research object,33 patients were received for oral Mosa Billy treatment as control group,34 patients were received oral Dalitz Tong granule for treatment as the observation group,two groups of patients with treatment,analyze the clinical were compared.ResultsBefore treatment,the patients of two groups with heartburn,nausea and vomiting,abdominal distension and other clinical symptoms scores were showed no significant difference(P＞0.05),after treatment,the clinical symptom score of observation group was significantly better than that of control group,there was significant difference(P＜0.05);the total efficiency of control group was 57.6%,total efficiency of the observation group was 88.2%,the observation group was significantly higher than that of control group(P＜0.05);the control group after treatment of gastric emptying rate was significantly better than that of observation group(P＜0.05).ConclusionDalitong granule in the treatment of functional gastroduodenal disease clinical curative effect,it is worthy of popularization and application in clinical practice.
		2016 Vol. 23 (35): 123-125 [Abstract] ( 121 ) HTML (36 KB) PDF (0 KB) ( 37 )

	126	The clinical effect of high dose gamma globulin in the treatment of viral encephalitis in children
		LIU Peng
		ObjectiveTo investigate the clinical efficacy of intravenous injection of large dose of gamma globulin in children with viral encephalitis.Methods60 cases of children with viral encephalitis were admitted to the department of pediatrics from January 2013 to September 2016,they were randomly divided into treatment group and control group, 30 cases in each group.On the basis of routine treatment in two groups,the treatment group was given intravenous infusion of gamma globulin.The total effective rate of the two groups were compared and the curative effect was observed by comparing the time of fever relief,the time to stop seizure,the time of turning consciousness and the total days of hospitalization.ResultsIn the treatment group,the time of fever relief,the time of seizure,the turn of consciousness and the total number of days of hospitalization were shorter than those of control group(P＜0.05),the total effective rate of treatment group was 96.7%,higher than that of control group of 63.3%(P＜0.01).ConclusionLarge doses of gamma globulin in the treatment of viral encephalitis in the improvement of clinical symptoms and signs,it has more significant effect,it can reduce the number of hospital days.
		2016 Vol. 23 (35): 126-128 [Abstract] ( 116 ) HTML (39 KB) PDF (0 KB) ( 38 )

	129	The clinical analyzing of treatment primary nephrotic syndrome by tacrolimus
		WEI Jian-bo;NING Fang-fang;LU Qin-yan
		ObjectiveTo explore the clinical effects of treatment primary nephrotic syndrome by tacrolimus.Methods30 cases clinical data of primary nephrotic syndrome patients in our hospital department of nephrology from February 2011 to March 2015 were selected,and divided into two groups by different treatment methods,the control group（cytoxan compared with prednisone acetate treatment）15 cases and the Tacrolimus group （prednisone acetate compared with tacrolimus treatment）15 cases.The serum albumin,creatinine,cholesterol,triglyceride,urine protein quantitation of two groups primary nephrotic syndrome patients before treatment and after treatment 6 moths were compared,clinical curative effect of two groups primary nephrotic syndrome patients were compared.ResultsThe serum albumin,creatinine, cholesterol,triglyceride,urine protein quantitation of two groups primary nephrotic syndrome patients before treatment were no significant difference(P＞0.05),the serum albumin of control group and Tacrolimus group after treatment 6 moths were higher than before treatment;the creatinine,cholesterol,triglyceride,urine protein quantitation were lower than before treatment;the serum albumin of Tacrolimus group after treatment 6 moths was higher than that of control group;the creatinine,cholesterol,triglyceride,urine protein quantitation were lower than that of control group;the remission rate of treatment group was higher than that of control group,the differences were significant(χ2=7.65，P＜0.05).ConclusionThe clinical symptoms of treatment primary nephrotic syndrome by tacrolimus is obviously,remission rate is high,it is worth to be used.
		2016 Vol. 23 (35): 129-131 [Abstract] ( 130 ) HTML (35 KB) PDF (0 KB) ( 37 )

	132	A new method of alveolar lavage in rat and mouse set up applying mouse stomach needle and point sample suction head
		YANG Biao;XIAO Chun-ling
		ObjectiveTo develop a new method for easy rat and mouse alveolar lavage.MethodsMouse stomach needle and electrophoresis point sample suction head applied to develop a new alveolar lavage operation system in rat and mouse.Sterile syringe of 10 ml or 1 ml was used respectively to complete the alveolar lavage with the intubation tool. Ten male Wistar rats(weight was 220-250 g)and ten male CB17-SCID mice(weight was 24-28 g)were performed for intubation and alveolar lavage fluid collection.Results20 times of intubation and alveolar lavage operation were completed.1×107alveolar macrophages from rat and 3×106alveolar macrophages from mouse were successfully collected.ConclusionA new method of alveolar lavage in rat and mouse set up applying mouse stomach needle and point sample suction head can be widely used in the study of respiratory disease model in rat and mouse.
		2016 Vol. 23 (35): 132-134 [Abstract] ( 135 ) HTML (39 KB) PDF (0 KB) ( 28 )

	135	Effect of Esmolol on the expression of COX-2 mRNA in spinal cord of inflammatory rats
		CHEN Ye;ZOU Cong-hua;ZHENG Xiao-chun
		ObjectiveTo investigate the effect of intrathecal injection of Esmolol on the expression of COX-2 mRNA in the spinal dorsal horn of formaldehyde-induced inflammatory rats.MethodsAfter the intrathecal catheterization,36 SD rats were randomly divided into 3 groups (n=12):saline group (group N),300 μg/kg group (group S1),and 600 μg/kg group (group S2).5 days after the intrathecal catheterization,the drug of each group was given to the rats respectively and then 50 μl formaldehyde was injected subcutaneously in the hind limbs of rats.Von-Frey method and Hargreaves method were adopted to measure the mechanical withdrawal threshold(MWT)and thermal withdrawal latency(TWL)so as to observe the pain behavioral changes in rats.After 1.5 hours observation,RT-PCR was given to observe COX-2 mRNA expression in L4～5spinal dorsal horn.ResultsCompared with group N,phase II pain behaviors in group S1 and group S2 were reduced and the expression of COX-2 mRNA in L4～5spinal dorsal horn in group S1 and group S2 was less than that in group N (P＜0.01).ConclusionIntrathecal injection of Esmolol reduces COX-2 mRNA expression in the spinal dorsal horn of formalin-induced rats.
		2016 Vol. 23 (35): 135-137 [Abstract] ( 131 ) HTML (40 KB) PDF (0 KB) ( 21 )

	138	Influence of Ethanol intake on serum oxidized low-density lipoprotein in rats fed with high fat diet
		LIU Jun;SHEN Qiang;BAO Zhong-wu;GUO Shen-yi
		ObjectiveTo investigate the influence of Ethanol intake on serum oxidized low-density lipoprotein in rats fed with high fat diet.Methods16 male SD rats with 6 weeks of age were fed with high fat diet,and these 16 rats were randomly divided into control group and Ethanol group (50%Ethanol,1 ml/(100 g·d).The total cholesterol(TC),triglyceride(TG),high-density lipoprotein(HDL),low-density lipoprotein(LDL)and oxidized low-density lipoprotein(ox-LDL) levels of blood serum were determined before experiment and after 8 weeks experiment.ResultsThe TC,TG,HDL,LDL and ox-LDL had a significant change in both two group before and after experiment(P＜0.05).Compared with control group,the ox-LDL levelof blood serum was obviously increased in ethanol group(P＜0.05),but TC,TG,HDL and LDL had no significant difference in both groups(P＞0.05).ConclusionIntake of ethanol can significantly increase ox-LDL in serum of SD rats.
		2016 Vol. 23 (35): 138-140 [Abstract] ( 150 ) HTML (41 KB) PDF (0 KB) ( 39 )

	141	Analysis of epidemiological and clinical features of measles in 1143 cases and the relations with the history of immune
		CHEN Li;HU Shu-yun;LIU Chao-ying;ZHONG Fu-jun;XIN Run-hong
		ObjectiveTo understand the epidemiological and clinical characteristics of measles in Yichun city and the relations with the history of immune.MethodsReported measles from January 2006 to December 2015 in the hospitals of Yichun City were analysed by descriptive epidemiological methods.ResultsTotal 1143 cases were reported in Yichun City during 2006-2015.The male/female ratio and average incidence per year were 2.19∶1.00 and 2.09/100 000, respectively.The distribution of incidence was the highest in the 2009.Most of cases were sporadic,which were giving priority to with the population of permanent residents and were the onset age mainly under the age of 7,accounted for 74.34%.The higher incidence was happened from March to August,and the April and the May had the highest incidence.The distribution of incidence was the highest in Wanzai county,in which there was no case during 2012-2014 after the mass vaccination campaign.The distribution of incidence was the lowest in Tonggu county.The main factors of measles occurrence were because of no vaccination history.The history of immune of reported measles in the main were 0 times,accounted for 47.07%.ConclusionThe measles incidence was given priority to with distributed in Yichun city, onset age was given priority to with age under the age of 7,the main factors of measles occurrence were because of no vaccination history.After the strengthen measles vaccination,any of counties measles incidence decreased obviously.The clinical poisoning symptoms of measles patients with immune history was milder than that without immune history.With the increase of age,the measles clinical symptoms gradually reduced,but the incidence of large age combined with lymph node enlargement and diarrhea was higher than that of small age group.
		2016 Vol. 23 (35): 141-145 [Abstract] ( 108 ) HTML (53 KB) PDF (0 KB) ( 30 )

	146	Study of the influence on negative emotion of mental stress in the family tenders with schizophrenia
		CUI Jian;LI Zun-qing
		ObjectiveTo explore the relation between mental stress and negative emotion of the family tenders with schizophrenia.Methods100 family tenders with schizophrenia (the study group)who were treated in Mental Disease Prevention and Treatment Hospital of Jining City from May to July in 2016 were researched by using chinese perceived stress scale(CPSS),self-rating anxiety scale(SAS),self-rating depression scale(SDS),who were compared with 100 health crowd(the control group)at the same period.ResultsThe score of CPSS in the study group was(25.68±6.47)points,which was higher than (19.76±5.16)points in the control group,with significant difference (P＜0.01).The score of SAS,SDS in the study group was(52.57±6.33)points,(53.32±7.25)points respectively,which was higher than (32.13±6.58)points, (32.13±6.58)points in the control group,with significant difference (P＜0.01).Correlation analysis showed that there was positive correlation between mental stress and negative emotion.Multiple regression analysis showed that mental stress explained 21.6%of the variance of anxious,21.6%of the variance of depression.ConclusionMental stress is predictive factor of negative emotion of the family tenders with schizophrenia.
		2016 Vol. 23 (35): 146-148 [Abstract] ( 137 ) HTML (39 KB) PDF (0 KB) ( 43 )

	149	Nutritional risk status and related factors analysis for multi-drug resistant pulmonary tuberculosis patients

		ObjectiveTo investigate the nutritional risk status and related factors for multi-drug resistant pulmonary tuberculosis(MDR-TB)patients.MethodsTB patients who were treated in our hospital from January 2013 to December 2015 were collected and involved in questionnaire survey to make an assessment of the nutritional risk status for MDR-TB patients by using the nutritional risk screening scale (NRS2002).The data were collected from patients and statistically analyzed,included general information,clinical symptoms,age,onset time,fatigue,insomnia,depression,comorbidity and social support.ResultsIn this study,the average nutritional risk score of MDR-TB patients was(3.53±1.50)points, among which patients with NRS2002 greater than or equal to 3 points accounted for 79.4%.The age,clinical symptoms, onset time,comorbidity,insomnia and depression were the related factors influencing the nutritional risk status for MDRTB patients.ConclusionFor MDR-TB patients who have nutritional risks in general,close attentions should be paid to their nutritional status.The nutritional risk factors of MDR-TB patients include age,clinical symptoms,onset time,comorbidity,insomnia and depression.Formulation of specific intervention measures will help reduce the incidence of nutritional risks.
		2016 Vol. 23 (35): 149-151转155 [Abstract] ( 143 ) HTML (40 KB) PDF (0 KB) ( 35 )

	152	Distribution of pathogens and analysis of antimicrobial agents applied in patients with urinary tract infection
		WANG Wei
		ObjectiveTo analyze the usage of antibacterial agents based on the characteristics of pathogenic bacteria and drug resistance in inpatients with urinary tract infection (UTI),in order to promote its rational use.MethodsBy a retrospective analysis,bacterial culture from midstream urine was carried out in inpatients with UTI from March 2014 to February 2015 in some hospital.Based on the results of bacterial culture and drug sensitive test,the preferred antibacterial drugs from empirical usage were analyzed.ResultsAmong 125 isolated strains of pathogenic bacteria,the percentage of Gram-negative and Gram-positive bacteria,and fungi was 91.20%,8.00%,and 0.80%.Escherichia coli,Proteus mirabilis,and Klebsiella pneumonia were commonly seen in the Gram-negative bacteria.In the Gram-positive bacteria, Enterococcus faecalis and Enterococcus faecium took the majority.Gram-negative bacteria were basically resistant to antibacterial drugs like β-lactam and quinolone,and even Proteus mirabilis was resistant to imipenem.To most of antibacterial agents,Gram-positive bacteria were resistant,especially Enterococcus faecium was resistant to all antibacterial agents after drug sensitive test.ConclusionApplication of preferred antibacterial drugs based on clinical experience in UTI inpatients is not rational.The antimicrobial agents which are listed in drug sensitive card and used in the susceptibility test have to be replaced for widespread resistance due to a long time usage.
		2016 Vol. 23 (35): 152-155 [Abstract] ( 136 ) HTML (40 KB) PDF (0 KB) ( 37 )

	156	Exploration of combination of hospital and community special disease management mode for chronic heart failure with integrated traditional Chinese and Western Medicine
		HUANG Gui-qiong;HONG Xiao-hua;ZHOU Qiao-qi;CHEN Hong;LI Rong;YAO Zhi-qiang
		ObjectiveTo study the clinical effect of combination of hospital and community special disease management mode of TCM and Western medicine for chronic heart failure (CHF).Methods150 patients with CHF treated in our hospital from May 2015 to May 2016 were selected and randomly divided into two groups,75 cases in each group.Patients in control group adopted the existing medical mode,patients in observation group adopted hospital and community special disease management mode of TCM and Western medicine.The clinical effect between two groups was observed.ResultsThe difference of proper exercise,low salt diet,quiting smoking and medication compliance before and after administration in two groups had statistical significance(P＜0.05);after administration,proper exercise,low salt diet,quiting smoking and medication compliance in the observation group was significantly higher than that in the control group,and the difference was statistically significant(P＜0.05).The total effective rate of cardiac function in the observation group was 90.7%,higher than 73.3%in the control group,and the difference was statistically significant(P＜0.05).After management, QOL integral and LVEF of the observation group was significantly better than that of the control group,and the difference was statistically significant(P＜0.05).The total mortality rate,rehospitalization rate,emergency rate and deterioration rate in the observation group was significantly lower than that in the control group,and the difference was statistically significant (P＜0.05).ConclusionFor patients with CHF,hospital and community special disease management mode of TCM and Western medicine can improve the patient′s compliance,treatment effect,prognosis and life quality.It is worthy of promotion.
		2016 Vol. 23 (35): 156-158 [Abstract] ( 127 ) HTML (42 KB) PDF (0 KB) ( 39 )

	159	The application of risk management in the outpatient
		LIANG Jie-ping;YU Xiu-qing;GUAN Qun-rui
		ObjectiveTo explore application effects of risk management in the outpatient.Methods65 cases outpatient nurses in our hospital from February 2013 to March 2016 were selected as study objects and divided into two groups by carrying out risk management or not,control group (no carrying out risk management group)30 cases and observation group(carrying out risk management group)35 cases.The outpatient nursing quality score,comprehensive quality score and risk events rate of two groups were observed.ResultsThe professional knowledge [(90.1±8.7)scores],disinfection and isolation[(90.3±9.0)scores],nursing safety[(91.0±8.5)scores],nursing rounds score[(90.4±8.6)scores]in the observation group was higher than(80.3±10.6),(78.9±10.6),(79.7±9.8),(79.9±9.6)scores in the control group;the nursing application [(4.1±0.5)scores],group cohesion [(4.0±0.4)scores],making compromises [(4.0±0.6)scores],activity confidence [(4.2±0.4)scores],responsibility [(4.1±0.5)scores],problem solving [(4.2±0.6)scores],honor sense scores [(4.2±0.4) scores]in the observation group was higher than(3.0±0.6),(3.1±0.5),(3.2±0.6),(3.3±0.5),(3.4±0.4),(3.5±0.6),(3.6±0.5)scores in the control group;surgical infection rate,triage error rater,nurse patient disputes risk events rater in the observation group was 2.9%,lower than 23.3%in the control group,the difference all was statistical significance(all P＜0.05).Conclusion The application of risk management in the outpatient could improve nursing work quality and comprehensive quality of nursing staff,decrease rate of risk events,which is worthy clinical application.
		2016 Vol. 23 (35): 159-161 [Abstract] ( 136 ) HTML (42 KB) PDF (0 KB) ( 28 )

	162	Investigation and Consideration on the value cognition of SCI papers in hospitals
		LUO Juan;JIANG Pan;LI Sun-fei;WU Ying-chao
		ObjectiveTo investigate the status of＂SCI fever＂and explore the correct value orientationin in hospital.MethodsThrough 18 medical units of telephone survey,whether SCI was listed as an important indicator of professional title evaluation and reward.The questionnaire survey was conducted to investigate the attitude of SCI as evalueting indicator,the relationship between the number of medical papers and the medical level,and cognition of clinical practice transformation among 221 medical technicians in 4 hospitals.ResultsIn 18 medical units,SCI was listed as an important indicator of professional title evaluation and reward.In 221 questionnaires,50.7%of the staff wrote SIC papers,which was prepared for title and assessment;59.3%thought that SCI was reasonable but not only,49.7%of the staff did not know the practice transformation of SCI.ConclusionThe value orientation of SCI in the hospital has excessive deification,blind worship,distort the essence of value and so on.The state should pay attention to the policy orientation of science and technology.The hospital should treat the advantages and disadvantages of SCI scientifically,and made the scientific evaluation system through the combine of research and clinical performance,the combine of quantitative and qualitative,the combine of achievement and transform.
		2016 Vol. 23 (35): 162-164 [Abstract] ( 151 ) HTML (39 KB) PDF (0 KB) ( 35 )

	165	Application effects of risk awareness management in nursing management of operating room
		DUAN Min;SHI Lei
		ObjectiveTo explore the application effects of risk awareness management in the nursing management of operating room.MethodsA total of 600 patients undergoing surgical treatment in our hospital from January 2015 to September 2016 were randomly divided into experimental group and control group,with 300 patients in each group.Risk awareness management was applied in the experiment group,and regular nursing was applied in the control group.The occurrence of risk events,complaints and disputes,the degree of satisfaction towards nursing care were compared between two groups and clinical effects were evaluated.ResultsThere were 13 cases(4.33%)of risk events in the experimental group,significantly lower than 33 cases(11.00%)in the control group,and the difference was statistically significant (P＜0.05).In the experimental group,medical dispute and complaint was seen in 1 case respectively,significantly lower than 15 complaints and 8 disputes in the control group,and the difference was statistically significant(P＜0.05).The scores of nursing satisfaction in the experimental group was significantly higher than that in the control group,and the difference was statistically significant(P＜0.05).ConclusionThe application of risk awareness management is gradually strengthened by the nursing staff′s own risk consciousness,and the nurses are more careful in the work,which can reduce the occurrence of various kinds of risks.It is of great significance to reduce the medical disputes,relieve the doctor-patient relationship,and enhance the satisfaction of the patients to the nursing team,which is worthy of clinical promotion.
		2016 Vol. 23 (35): 165-167 [Abstract] ( 145 ) HTML (39 KB) PDF (0 KB) ( 31 )

	168	Congenital absence of corpus callosum combined with quadrigeminal cyst in 1 case and literature review
		XIAO Ling-ling;WU Shu-juan;LU Li-hua;WANG Ji-mei
		Congenital defects are one of the major diseases that endanger health of the newborns.This study reviewed the clinical data of one child who had congenital absence of corpus callosum combined with quadrigeminal cyst and learned the relevant literature,to investigate the clinical features,prognosis and diagnosis methods of congenital absence of corpus callosum.The disease has diverse clinical manifestations,complex type of corpus callosum has poor prognosis. The combination of clinical manifestations,physical examination,brain ultrasound or MRI could prompt diagnosis.
		2016 Vol. 23 (35): 168-170 [Abstract] ( 160 ) HTML (35 KB) PDF (0 KB) ( 28 )

	171	Diagnosis and treatment analysis of one patient with transient ischemic attack
		YIN Lin-ling;QIAN Hai-zhou;YU Fei-cheng
		One case confirmed transient ischemic attack(TIA)with recurrent in our department recently was retrospectively analyzed,total cerebral angiogram and adjust the treatment plan were performed after that the patient gradually was stable.Through the analysis of clinical data and summary of the newest related literature,TIA is strong,powerful and early warning signal of cerebral infarction,the corresponding early clinical intervention should be carried out according to the different causes of patients.
		2016 Vol. 23 (35): 171-173转177 [Abstract] ( 172 ) HTML (36 KB) PDF (0 KB) ( 28 )

	174	The effect of early health intervention for elderly patients with cardiovascular disease
		ZHOU Xia;ZHOU Guang-qing;YI Song;HONG Xu-xing;LIU Chan;KUANG Yu-min
		ObjectiveTo investigate the effect of early health intervention for elderly patients with cardiovascular disease.Methods140 patients with cardiovascular disease treated in Department of Cardiovascular of Southern Hospital from February 2013 to March 2015 were randomly selected and divided into observation group and control group,70 cases in each group.Patients in the observation group were given early health intervention on the basis of the usual treatment and patients in the control group were given routine care program based on the original model of care,psychology,organic diseases improvement rate and compliance changes in two groups before and after intervention for one month were compared after.ResultsVarious negative psychological and emotional incidence after intervention in the observation group was significantly lower than that before intervention and in the control group (P＜0.05);intermittent dizziness, memory loss,headache,insomnia,chest tightness,palpitation and other physical organic disease improvement rate after intervention in the observation group was significantly higher than that before intervention and in the control group (P＜0.05);in the observation group,the scores of medication,dietary habits and regular work and rest compliance after intervention was higher than that before intervention and in the control group,but the difference was not statistically significant(P＞0.05).ConclusionEarly health intervention on psychological state and organic diseases recovery of elderly patients with cardiovascular diseases is significant,although improvement effect of medication and life style compliance is not obvious,there are obvious improvements for psychological and physiological changes of patients,which has a positive effect on the construction of the early health intervention mode.
		2016 Vol. 23 (35): 174-177 [Abstract] ( 131 ) HTML (44 KB) PDF (0 KB) ( 4 )

	178	Effect of local medication combined with nursing intervention on recurrent mycotic vaginitis
		LIU Xue-ying
		ObjectiveTo explore the clinical effect of local medication combined with nursing intervention on recurrent mycotic vaginitis.MethodsFrom December 2012 to December 2014,178 patients with recurrent mycotic vaginitis treated in Maternal and Child Health Care Hospital of Yongfeng County were selected as research objects and randomly divided into two groups according to SPSS 20.0 statistics software package of computer,89 cases in each group.Patients in the control group were given drug treatment alone,including intensive treatment(Fluconazole 150 mg,once daily;night with 20%sodium bicarbonate water bath,each time about 15 minutes before going to bed;the application of a Mico Nazole Nitrate Suppositories 200 mg,once a night)and consolidation therapy(with local medication,medication for bedtime application of a Mico Nazole Nitrate Suppositories 200 mg,once a night),patients in the observation group were used local drug combined nursing intervention,the causes in two groups were analyzed,the total efficiency of treatment,the recurrence rate and the incidence of adverse reactions were compared between two groups.ResultsThe main etiological factors in two groups included contacted infection of bathing or medical devices,sexual life process infection,candida albicans infection and other factors,there was no significant difference in the proportion of factors infection between two groups(P＞0.05).The total effective rate in the observation group was 94.38%,with 64.04%in the control group,and the difference was statistically significant(P＜0.05).The recurrence rate of the observation group was 7.89%,better than 31.46% of the control group,with statistical significance(P＜0.05).The incidence rate of adverse reactions was compared between two groups,the observation group was lower(P＜0.05).ConclusionLocal medication combined with nursing intervention in the treatment of recurrent mycotic vaginitis can get better results,effectively control the recurrence after treatment.
		2016 Vol. 23 (35): 178-180转189 [Abstract] ( 148 ) HTML (42 KB) PDF (0 KB) ( 31 )

	181	The clinical study of continuity-careinterventionin the promoting of healthy behaviors and blood pressure control in elderly hypertensive patients
		LIANG Rui-xia HUANG Feng-xia
		ObjectiveTo explore the clinical effects of continuity-care interventionin the promoting of healthy behaviors and blood pressure control in elderly hypertensive patients.Methods216 elderly hypertensive patients from October 2014 to August 2016 who were treated in our hospital were selected and randomly divided into control group and observation group according to the ID number.The control group were given hypertensive routine nursing intervention, the observation group were given continuity-care intervention on the basic of control group.The health behavioral and cognitive scores and maintenance of blood pressure were compared.ResultsAll the health behavioral and cognitive scores in observation group were significantly better than those of control group (P＜0.05),the SBP was（118.3±12.4）mmHg and DBP was（85.6±11.1）mmHg of observation group,there was significantly better than the SBP[（126.3±15.1）mmHg]and DBP [（97.2±7.2）mmHg]of control group (P＜0.05).ConclusionThe application of continuity-care intervention to elderly hypertensive patients is effective,which can promote healthy behaviors and blood pressure control and deserve a further application.
		2016 Vol. 23 (35): 181-183 [Abstract] ( 130 ) HTML (38 KB) PDF (0 KB) ( 35 )

	184	Study on the clinical effect of the implementation the integration with full responsibility nursing in the blood purification center
		SU Hui-juan
		ObjectiveTo explore the clinical effect of the integration with full responsibility nursing care of the whole blood purification center.Methods80 hemodialysis patients from April 2013 to June 2015 were selected and divided into two groups,40 patients in each group,the patients in the observation group were treated with integration with full responsibility nursing,the control group of patients were used conventional care,after nursing,the satisfaction degree and one-time puncture success rate of two groups were compared.ResultsPatients with one-time puncture success rate was 95.00%,was significantly better than that of control group of 80.00%,the satisfaction degree of the observation group was 97.50%,was significantly higher than that of control group of 77.50%(P＜0.05).ConclusionThe implementation level of the blood purification center full responsibility for the integration of nursing has a good clinical effect.
		2016 Vol. 23 (35): 184-186 [Abstract] ( 129 ) HTML (38 KB) PDF (0 KB) ( 41 )

	187	Effect of high quality nursing care on pain degree and quality of life in the patients with advanced gastric cancer
		HUANG Ning-ning
		ObjectiveTo explore the effect of high quality nursing care on pain degree and quality of life in the patients with advanced gastric cancer.Methods70 patients with advanced gastric cancer from May 2013 to April 2016 who were admitted in our hospital and were randomly divided into two groups,35 cases in each group.The observation group was given high quality care,and the control group was given routine care.The pain scores and quality of life in the patients with advanced gastric cancer after nursing care were compared between the two groups.ResultsThe pain score in the observation group was(1.05±0.75)scores lower than that of control group(3.21±0.15)scores,and the score of items in EORTC QLQ-C30 were higher than that of control group(P＜0.05).ConclusionThe high quality care can significantly reduce the pain degree in the patients with advanced gastric cancer,and improve their quality of life.
		2016 Vol. 23 (35): 187-189 [Abstract] ( 116 ) HTML (38 KB) PDF (0 KB) ( 11 )

	190	The study of the inference of different breech delivery modes on infants and relevant nursing measures
		ZHU Xi-mei;WU Wei-fang;YE Xiao-ying
		ObjectiveTo explore the prognosis of different breech delivery modes on infants and discuss methods of delivery and nursing measures to improve maternal and infant health.MethodsRetrospective analysis of 317 cases of breech delivery clinical data in our hospital from March 2014 to April 2016,283 cases of cesarean section(group A),34 cases of vaginal delivery(group B),the neonatal weights,the neonatal deaths and complications of two groups were compared.ResultsNewborns with a lower than 3.00 kg of group A was 42.76%（121 cases）,the group B was 61.76%(21 cases),the group B was higher than that of group A,the difference was significant(P＜0.05).There were no one case died in two groups.There were 3 cases（1.06%）intracranial hemorrhage,6 cases（2.12%）aspiration pneumonia in group A and none of birth injury,the incidence rate of cornplication was 3.18%.However,there was 1 cases（2.94%）intracranial hemorrhage,2 cases（5.88%）aspiration pneumonia and 3 cases（8.82%）birth injury in group B,the incidence rate of cornplication was 17.65%,the difference was significant（P＜0.01）.The Apgar score of group A was(7.26±1.06)scores, the group B was(4.57±1.20)scores,the difference was significant（P＜0.05）.ConclusionDetection timely of abnormal fetal position and carry out maternal health actively always can improve maternal and infant prognosis.
		2016 Vol. 23 (35): 190-191转194 [Abstract] ( 134 ) HTML (34 KB) PDF (0 KB) ( 27 )

	192	Observation of the effect of pre examination on the CT angiography of coronary artery
		HU Xi-e YUAN;Zhong-cao;ZHOU Lei;GUO Fen-ling;HUANG Xiu-ling
		ObjectiveTo investigate the coronary CT angiography before the interview results.Methods80 patients in our hospital from September 2014 to March 2015 were ready to CCTA examination were selected,and randomly divided into two groups,40 cases in each group,the control group was given Metoprolol,the nursing intervention group was given nursing intervention based on the treatment in control group,two groups of nursing with the success rate,and by experienced radiologists blinded evaluation of image quality of the two groups were compared.ResultsThe check the success rate of the control group was 62.5%,the nursing intervention group was 95.0%,the nursing intervention group was significantly higher than that of control group,there was significant difference (P＜0.05).The rate of excellent image quality of nursing intervention group was 95.0%,the image quality excellent rate of control group was 72.5%,the nursing intervention group was significantly better than that of control group,there was significant difference (P＜0.05).ConclusionThe patients with coronary artery CT angiography for patients before effective nursing visit intervention to improve the success rate of the examination is very helpful,it can be applied in clinic.
		2016 Vol. 23 (35): 192-194 [Abstract] ( 137 ) HTML (39 KB) PDF (0 KB) ( 26 )

	195	The effect of whole course high quality nursing model on primipara pregnancy outcome and postnatal mammary function
		HONG Qun-hui
		ObjectiveTo explore entire the effect of whole course high quality nursing model on primipara pregnancy outcome and postnatal mammary function.Methods196 primipara from October 2014 and October 2015 in our hospital were selected and randomly divided into control group and observation group according to the parity of ID number,98 cases in each group.The control group were given routine nursing,the observation group were given whole course high quality nursing.The cesarean section rate,postpartum initial time of lactation,3,7 d lacation ability score after delivery and pure breast feeding rates were compared.ResultsThe cesarean section rate of observation group was significantly lower than that of control group(P＜0.05),there was no significant difference in complications situation(P＞0.05);the time of lactation and 3,7 d lacation ability scores of observation group were better than those of control group(P＞0.01),pure breast feeding rates after 3 days,6 weeks and 3 months in the observation group were significantly better than those of control group(P＜0.05).ConclusionThe application of whole course high quality nursing model to primipara is feasible, which can reduce cesarean section rate,it improves the function of primipara lactation and exclusive breast-feeding.
		2016 Vol. 23 (35): 195-197 [Abstract] ( 142 ) HTML (39 KB) PDF (0 KB) ( 24 )

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