艾司洛尔对炎性大鼠脊髓COX-2 mRNA表达的影响

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Abstract ObjectiveTo investigate the effect of intrathecal injection of Esmolol on the expression of COX-2 mRNA in the spinal dorsal horn of formaldehyde-induced inflammatory rats.MethodsAfter the intrathecal catheterization,36 SD rats were randomly divided into 3 groups (n=12):saline group (group N),300 μg/kg group (group S1),and 600 μg/kg group (group S2).5 days after the intrathecal catheterization,the drug of each group was given to the rats respectively and then 50 μl formaldehyde was injected subcutaneously in the hind limbs of rats.Von-Frey method and Hargreaves method were adopted to measure the mechanical withdrawal threshold(MWT)and thermal withdrawal latency(TWL)so as to observe the pain behavioral changes in rats.After 1.5 hours observation,RT-PCR was given to observe COX-2 mRNA expression in L4～5spinal dorsal horn.ResultsCompared with group N,phase II pain behaviors in group S1 and group S2 were reduced and the expression of COX-2 mRNA in L4～5spinal dorsal horn in group S1 and group S2 was less than that in group N (P＜0.01).ConclusionIntrathecal injection of Esmolol reduces COX-2 mRNA expression in the spinal dorsal horn of formalin-induced rats.

Key words： Pain Spinal cord Esmolol Cyclooxygenase 2

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	CHEN Ye
	ZOU Cong-hua
	ZHENG Xiao-chun

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CHEN Ye,ZOU Cong-hua,ZHENG Xiao-chun. Effect of Esmolol on the expression of COX-2 mRNA in spinal cord of inflammatory rats[J]. 中国当代医药, 2016, 23(35): 135-137.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2016/V23/I35/135

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