中国当代医药

中国当代医药

Home

中文

中国当代医药

Forthcoming Articles

Advanced Search

Download Articles

Quick Search


2021 Vol. 28, No. 36 Published: 2021-12-28

	4	Research on the mechanism of Danxiong Huoxue Tablets in the treatment of osteoarthritis based on network pharmacology and molecular docking
		GUO Jinyan； LIANG Minglin； HUANG Yuzhi；ZENG Haojie；CHEN Qianwen； YANG Chun； DU Yikuan
		Objective To explore the mechanism of Danxiong Huoxue Tablets in the treatment of osteoarthritis based on network pharmacology.Methods The compound and target of Danxiong Huoxue Tablets and the gene of osteoarthritis were screened by database and literature, and the common target was mapped.The protein-protein interaction (PPI)network was constructed using Cytoscape 3.7.2, gene ontology (GO) and Kyoto encyclopedia of genes and genomes pathway enrichment (KEGG) were analyzed in DAVID V6.8 database, and the "component-target-pathway" network was constructed for molecular docking of key components.Results Obtained 50 components and 774 disease genes,331 GO functions and 61 KEGG pathways.Molecular docking results showed that the active ingredients were ferulic acid, sinapic acid, kaempferol, curcumin, etc.And the key targets were STAT3, vascular endothelial growth factor A(VEGFA), interleukin-6 (IL-6), tumor necrosis factor (TNF) and JUN, etc.KEGG was involved cancer, hepatitis B,NF-κB, PI3K-Akt and JAK-STAT signaling pathways.Conclusion Danxiong Huoxue Tablets may treat osteoarthritis through the expression of VEGFA, JUN and PI3K/Akt signaling pathway.
		2021 Vol. 28 (36): 4-8转33 [Abstract] ( 166 ) HTML (40 KB) PDF (0 KB) ( 8 )

	9	Clinical effect of endoscopic dissection/resection in the treatment of duodenal neuroendocrine tumors
		AI Meina
		Objective To explore the clinical effect of endoscopic dissection/resection in the treatment of duodenal neuroendocrine tumors (D-NENS).Methods A total of 83 patients with D-NENS admitted to General Hospital of Northern Theater Command from January, 2012 to July, 2017 were selected as the research objects.The patients were divided into the dissection group (n=41) and the resection group (n=42) according to the random number table method.Endoscopic mucosal resection (EMR) was performed in the excision group, and endoscopic mucosal dissection (EMD) was performed in the dissection group.The perioperative indexes, postoperative complications, changes of serum inflammatory factors before and after surgery, postoperative recurrence rate and mortality were analyzed in the two groups.Results There was no significant difference in tumor resection rate between the two groups (P＞0.05).The duration of operation and postoperative hospital recovery in the dissection group were shorter than those in the excision group, with statistical significance differences (P<0.05).The total incidence of postoperative complications in the dissection group was lower than that in the excision group, and the difference was statistically significant (P<0.05).There were no significant differences in the levels of IL-6 and CRP between the two groups before and 3 days after operation (P>0.05).At postoperative 3 days, the levels of IL-6 and CRP in the two groups were higher than those before surgery, and the differences were statistically significant (P<0.05).There was no significant difference in postoperative recurrence rate and mortality between the two groups (P＞0.05).Conclusion The clinical effect and prognosis of EMD and EMR in the treatment of D-NENS are similar, but the operative time and postoperative hospital stay of EMD are shorter, and the risk of postoperative complications is lower, which is worthy of clinical promotion and application.
		2021 Vol. 28 (36): 9-12 [Abstract] ( 68 ) HTML (35 KB) PDF (0 KB) ( 8 )

	13	Application of drug-thread drainage in fistula stage of plasma cell mastitis
		XIONG Weihua； YI Weizhen
		Objective To observe the clinical efficacy of drug line drainage in the treatment of plasma cellular mastitis fistula.Methods Thirty-six patients with fistula stage of plasma cell mastitis who were admitted to the Department of Breast Surgery, Anhui Provincial Hospital of Traditional Chinese Medicine from October 2020 to April 2021 were selected as the research objects, and they were divided into treatment group (20 cases) and control group (16 cases) by coin tossing method.All patients received oral Chinese medicine, the treatment group was treated with compound Huangbai liquid medicinal thread drainage, and the control group was treated with iodophor medicinal thread drainage.The hypersensitivity C-reactive protein (hs-CRP), erythrocyte sedimentation rate (ESR) and serum prolactin (PRL) levels, wound healing rate, wound healing time, wound healing time, scar area after healing, and recurrence rate were compared between the two groups.Results There was no significant difference in healing rate between the two groups(P>0.05).There was no significant difference in recurrence rate between the two groups (P>0.05).There was no significant difference in serum hs-CRP, ESR, PRL levels between the two groups before treatment (P>0.05).After treatment,serum hs-CRP, ESR, and PRL levels between the two groups were lower than before treatment, and the difference was statistically significant (P<0.05); after treatment, there were no statistically significant differences in hs-CRP, ESR, and PRL between the two groups (P>0.05).The healing time of the wound in the treatment group was shorter than that in the control group, and the scar after healing was smaller than that in the control group, with statistical significance (P<0.05).Conclusion Both groups of treatment plasma-celled mastitis fistula period have the advantages of fast fistula intake, small scarring, and no effect on aesthetics, among which the effect of drainage with yellow cypress liquid drug line is more significant.
		2021 Vol. 28 (36): 13-16 [Abstract] ( 49 ) HTML (37 KB) PDF (0 KB) ( 8 )

	17	The clinical application value of p16/Ki67 double stain detection in shunting cervical LSIL/HSIL and predicting the outcome of LSIL
		ZHANG Juan
		Objective Explore and analyze the shunt effect of p16/Ki67 double staining detection on cervical low-grade squamous intraepithelial lesion (LSIL) / high-grade squamous intraepithelial lesion (HSIL) and its predictive value for LSIL outcome.Methods A total of 300 patients with cervical diseases who were admitted to Zibo Maternal and Child Health Hospital of Shandong Province from January 2019 to February 2020 were selected to carry out cytological diagnosis, all patients underwent cytological diagnosis, histological diagnosis, and p16/Ki67 double staining test.According to the diagnosis of cervical cytology, patients are divided into four groups: no intraepithelial neoplasia and malignant cells (NILM), atypical squamous cells of undetermined significance (ASCUS) , LSIL, and atypical squamous cells with squamous intraepithelial lesions several times higher cannot be excluded (ASU-H+), according to different cervical histological diagnosis results, they are divided into four groups: cervicitis, LSIL, HSIL and cervical cancer.The positive rate of p16/Ki67 double-stain test for patients with different cytological diagnosis results and different histological diagnosis results, calculate the diagnostic efficiency of p16/Ki67 double-stain test for cervical histological diagnosis results,HSIL and cervical cancer, and count the cervical tissues The outcome of patients with LSIL after a 1-year follow-up were compared.Results Cervical cytology results showed that the positive rate of p16/Ki67 double staining in the ASCUS group and the LSIL group was not statistically significant (P＞0.05); the positive rate of p16/Ki67 double staining in the NILM group was lower than that of ASCUS Group, the difference was statistically significant (P<0.05).The positive rate of p16/Ki67 double staining in the NILM group was lower than that of the LSIL group, and the difference was statistically significant (P<0.05).The NULM group was p16 The positive rate of /Ki67 double staining was lower than that of the ASU-H+ group, and the difference was statistically significant (P<0.05).The positive rate of p16/Ki67 double staining in the ASCUS group was lower than that of the ASU-H+ group, and the difference was statistically significant Significance (P＞0.05).The positive rate of p16/Ki67 double staining in the LSIL group was lower than that of the ASUH+ group, and the difference was statistically significant (P<0.05).Cervical histological diagnosis showed that the positive rate of p16/Ki67 double staining in the HSIL group and the cervical cancer group was not statistically significant(P<0.05).The positive rate of p16/Ki67 double staining in the cervicitis group was low In the LSIL group, the difference was statistically significant (P<0.05).The positive rate of p16/Ki67 double staining in the cervicitis group was lower than that in the HSIL group, and the difference was statistically significant (P＞0.05).The positive rate of p16/Ki67 double staining in the cervicitis group was lower than that of the cervical cancer group, and the difference was statistically significant (P<0.05).The positive rate of p16/Ki67 double staining in the LSIL group was lower than that of the HSIL group, and the difference was statistically significant (P<0.05).The positive rate of p16/Ki67 double staining in the LSIL group was lower than that of the cervical cancer group, the difference was statistically significant (P<0.05).The results of p16/Ki67 double staining in 300 patients showed that there were 145 patients with positive HSIL and cervical cancer, the sensitivity was 91.20%, the specificity was 82.23%, and the positive predictive value was 78.62%.One year follow-up of 74 patients with LSIL diagnosed by cervical histology showed that patients with negative p16/Ki67 double staining had significantly lower probability of lesion progression than patients with positive p16/Ki67 double staining,the difference was statistically significant(P<0.05).Conclusion p16/Ki67 double staining detection can effectively diagnose the severity of cervical disease, shunt LSIL/HSIL, and has high predictive value for the prognosis of LSIL, which is worthy of clinical application.
		2021 Vol. 28 (36): 17-21 [Abstract] ( 42 ) HTML (41 KB) PDF (0 KB) ( 6 )

	22	Genomic biomarker investigation for metastasis of breast cancer by combined bioinformatic gene expression profile analysis
		WU Qiqiao；ZHANG Shumin； ZHENG Tingting；LIU Juan；HU Yong； LIN Dengqiang； DAI Mengting；SUN Jing
		Objective To identify potential genetic markers associated with breast cancer metastasis and to perform survival analysis.Methods The comprehensive Gene Expression Omnibus (GEO) was used to screen differentially expressed genes (DEGs) between metastatic and non-metastatic sites of breast cancer.Gene ontology (GO) and Kyoto encyclopedia of genes and genomes (KEGG) pathway enrichment analyses were performed, the protein-protein interaction(PPI) network was constructed, and module analysis was performed using MCODE.Then, overall survival (OS) and distant metastasis free survival (DMFS) analysis of hub genes was performed by the Kaplan-Meier plotter online tool.The correlations between hub genes and clinical stages were validated through GEPIA online tool.Results A total of 295 DEGs were obtained, which were significantly enriched in the terms related to extracellular exosome, focal adhesion,cell division.KEGG pathway analysis showed that the significant pathways included mitogen-activated protein kinase(MAPK) signaling pathway, Rap1 signaling pathway, cell adhesion molecules (CAMs), antigen processing and presentation.The PPI network was established with 280 nodes and 357 edges.Ten modules were found from the PPI network.Conclusion A total of 20 genes were selected as hub genes, among which, low expression of TYMS, SKA1, ADCY7 and high expression of MX1 were related with worse overall survival.Low expression of POLR3H and high expression of CDCA8, ASE1, KIF14, MX1 were associated with worse DMFS.POLR3H and PRC1 may serve as new biomarker in diagnosing metastasis of breast cancer or potential drug target.
		2021 Vol. 28 (36): 22-28 [Abstract] ( 54 ) HTML (44 KB) PDF (0 KB) ( 9 )

	29	Research progress on low back pain in nursing students
		RUAN Dan； CHEN Huanqin ；HUANG Liqun
		Low back pain (LBP) is a significant health problem.Nonspecific LBP refers to pain that occurs between the first lumbar spine and the coccyx in the absence of a specific systemic disease.LBP will affect nursing students′quality of life, employment rate and career quality, and bring a burden to society.This paper summarizes the commonly used LBP measurement tools (Nordic low back pain questionnaire, skeletal muscle questionnaire, etc.), and comprehensively expounds the influencing factors of LBP of nursing students in colleges and universities from the aspects of general demography, lifestyle and occupation factors, physiology and psychology.Found a student nurse, age, gender, family history of LBP, smoking history, history of sedentary, often riding and walking, being rational pressure (such as a long time to bend over, lift, carry, push, pull, etc.), obesity, poor self-reported health, poor quality of sleep, back muscle endurance, height, anxiety, depression, stress and pain of belief are the influence factors of LBP.Summarizes the treatment of LBP (drug therapy, physical therapy, electrotherapy, treatment, orthoses, associated with traumatic injection treatment of traditional Chinese medicine, the environment changes, cognitive intervention, intervention, position), and finally puts forward the existing studies have limitations, in the hope of providing theoretical basis for further broadening the research of this field.
		2021 Vol. 28 (36): 29-33 [Abstract] ( 50 ) HTML (41 KB) PDF (0 KB) ( 7 )

	34	Research progress in standardized treatment of obsessive-compulsive disorder
		LIN Dongmei； SUN Xu； ZHENG Leilei ；SONG Libo； ZHU Congqiao； JIA Meng
		Obsessive-compulsive disorder is a clinically common and complex mental disease, which is mainly characterized by repeated compulsive concepts and compulsive behavior.Obsessive-compulsive disorder has caused a great impact on patients′ mental health and daily life, and its treatment is also a major difficulty in the current clinical practice.In the standardized treatment of obsessive-compulsive disorder, they mainly include drug therapy, psychotherapy,physical therapy, and surgical treatment.Drug therapy is the main means of obsessive-compulsive disorder treatment,and the commonly used drugs include the tricyclic drugs Clopepamine and selective serotonin reuptake inhibitor.Cognitive behavioral therapy, mindfulness therapy, Morita therapy and other psychological treatment are important mean of obsessive-compulsive disorder treatment.And repeated transcranial magnetic stimulation, transcranial direct current stimulation and other physical therapy methods are mainly auxiliary treatment of obsessive-compulsive disorder, often combined with psychotropic drugs, to improve the clinical efficacy.For drug treatment, psychotherapy ineffective refractory obsessive-compulsive disorder patients, surgery can be used.At present, the common surgical methods include anterior buckle band destruction, internal sac anterior limb destruction, vagal nerve stimulation and deep brain electrical stimulation.This article will review the standardized treatment methods and related progress of obsessive-compulsive disorder, in order to provide reference for the treatment of obsessive-compulsive disorder.
		2021 Vol. 28 (36): 34-37 [Abstract] ( 57 ) HTML (39 KB) PDF (0 KB) ( 8 )

	38	Value of 64-slice Spiral CT in Diagnosis of Tetralogy of Fallot
		ZHANG Zhenhua； WU Zhuqiang； DING Shan
		Objective To explore the value of 64-slice spiral CT in the diagnosis of tetralogy of Fallot.Methods A total of 80 children with tetralogy of Fallot treated in Jiangxi Children′s Hospital from May 2012 to May 2016 were selected as the research subjects, all children received echocardiography and 64-slice spiral CT angiography.The results of echocardiography and 64-slice spiral CT angiography were compared using surgical results as the gold standard, the diagnostic value of the two methods was analyzed.Results After surgery, there were 331 cardiovascular malformations.The types of lesions included right ventricular hypertrophy, ventricular septal defect, pulmonary artery stenosis, and aortic straddle.The diagnostic sensitivity, specificity and accuracy of 64-slice spiral CT angiography were higher than those of echocardiography in pulmonary artery stenosis, ventricular septal defect, aortic riding, and right ventricular enlargement, the differences were statistically significant (P<0.05).Conclusion 64-slice spiral CT angiography has a high diagnostic accuracy rate for children with tetralogy of Fallot, and its specificity and sensitivity were high, which provides accurate and effective basis for early clinical surgery and improves the survival rate of children.
		2021 Vol. 28 (36): 38-40转43 [Abstract] ( 40 ) HTML (29 KB) PDF (0 KB) ( 7 )

	41	Clinical effect of Mesalazine combined with probiotics in the treatment of ulcerative colitis
		LIU Chang； LI Guofan
		Objective To investigate the clinical efficacy of Mesalazine combined with probiotics in the treatment of ulcerative colitis.Methods A total of 80 patients with ulcerative colitis diagnosed and treated in the Fifth Affiliated(Zhuhai) Hospital of Zunyi Medical University from January 2019 to January 2021 were selected as the research objects and divided into the control group and the observation group by random number table method, with 40 cases in each group.Mesalazine was treated in the control group and Mesalazine combined with probiotics was treated in the observation group.The treatment effect and serum C-reactive protein level before and after treatment were compared between the two groups.Results The total effective rate of observation group was 97.50%, higher than 85.00% of control group,and the difference was statistically significant (P<0.05).After treatment, the levels of serum C-reactive protein in the two groups were lower than those before treatment, and the level of serum C-reactive protein in observation group was lower than that in control group, the differences were statistically significant (P<0.05).Conclusion In the treatment of ulcerative colitis, the combination of Mesalazine and probiotics is better, can improve patients′ clinical symptoms, and the effect is better.It is worthy of clinical promotion and treatment.
		2021 Vol. 28 (36): 41-43 [Abstract] ( 55 ) HTML (30 KB) PDF (0 KB) ( 8 )

	44	Effect of Tiotropium Bromide combined with Budesonide on immune function and pulmonary ventilation function in patients with asthma -chronic obstructive pulmonary disease overlap syndrome
		SU Wei
		Objective To explore the effect of Tiotropium Bromide combined with Budesonide on immune function and pulmonary ventilation function in patients with asthma-chronic obstructive pulmonary disease overlap syndrome (ACOS).Methods A total of 94 patients with ACOS admitted to Shangrao Municipal Hospital between January 2019 and January 2020 were selected as the research subjects, and they were divided into the control group and the observation group according to the random number table method, with 47 cases in each group.The control group was treated with Budesonide Inhalation, and the observation group was treated with Tiotropium Bromide combined with Budesonide Inhalation.The clinical effect, pulmonary function, immune function indexes and total incidence of adverse reactions before and after treatment were compared between the two groups.Results The total effective rate of observation group was higher than that of control group, and the difference was statistically significant (P<0.05).After treatment, the forced expiratory volume in the first second (FEV1), the ratio of forced expiratory volume in the first second to forced vital capacity (FEV1/FVC), forced vital capacity (FVC) and inspiratory fraction (IC/TLC) in the observation group were higher than those in the control group, and the differences were statistically significant (P<0.05).After treatment, the levels of helper T cell type 1 (Th1), helper T cell type 2 (Th2) and Th1/Th2 in the two groups were higher than those before treatment, and the observation group was higher than of the control group, the differences were statistically significant (P<0.05).There was no statistically significant difference in the total incidence of adverse reactions between the two groups (P>0.05).Conclusion The combined application of Tiotropium Bromide and Budesonide in the treatment of patients with ACOS can effectively improve the pulmonary function and immune function, enhance the efficacy of clinical treatment and reduce the occurrence of adverse reactions.
		2021 Vol. 28 (36): 44-46转50 [Abstract] ( 43 ) HTML (33 KB) PDF (0 KB) ( 7 )

	47	Clinical effect of Insulin pump combined with Sitagliptin Phosphate in the treatment of newly diagnosed type 2 diabetes mellitus patients
		KANG Luchen； LI Wenbin； LAN Hao； LIU Bingling
		Objective To investigate the clinical effect of Insulin pump combined with Sitagliptin Phosphate in the treatment of newly diagnosed type 2 diabetes mellitus patients.Methods A total of 88 newly diagnosed type 2 diabetes mellitus patients who were treated in the First People′s Hospital of Jiujiang City from January 2018 to December 2019 were selected as the study subjects.According to random number table method, they were divided into control group(44 cases) and observation group (44 cases).The control group was treated with Insulin pump alone, and the observation group was treated with Sitagliptin Phosphate based on the control group.The blood glucose, insulin resistance, insulin dosage, time of reaching target of glucose and adverse reactions were compared between the two groups.Results There was no statistically significant difference in the blood glucose between the two groups before treatment (P>0.05).The levels of glycated hemoglobin (HbA1c), fasting plasma glucose (FPG) and 2 hours postprandial blood glucose (2 h PG)in the two groups after treatment were lower than those before treatment, with statistically significant differences (P<0.05).The HbA1c, FPG and 2 h PG in the observation group ([6.52±0.57] %, [5.68±0.51] mmol/L, [7.52±1.14] mmol/L] were lower than those in the control group ([7.34±0.85] %, [6.75±0.73] mmol/L, [8.69±1.23] mmol/L] after treatment, with statistically significant differences (P<0.05).There were no statistically significant differences in the homeostasis model assessment β (HOMA-β) and homeostasis model assessment-insulin resistance (HOMA-IR) between the two groups before treatment (P>0.05).The HOMA-β levels of the two groups after treatment were higher than those before treatment, and the HOMA-IR levels of the two groups after treatment were lower than those before treatment,with statistically significant differences (P<0.05).After treatment, HOMA-β in the observation group was (65.82±6.14),higher than that in the control group of (59.41±5.73), and HOMA-IR in the observation group was (2.95±0.63), lower than that in the control group of (3.41±0.85), the differences were statistically significant (P<0.05).The insulin dosage in the observation group ([14.67±4.31] U) was less than that in the control group ([20.15±5.16] U), the time of reaching target of glucose in the observation group ([8.31±1.25] d) was shorter than that in he control group ([11.84±2.69] d), and the total incidence of adverse reactions in observation group (4.55%) was lower than that in control group (20.45%), with statistically significant differences (P<0.05).Conclusion Insulin pump combined with Sitagliptin Phosphate can stabilize the blood glucose of newly diagnosed type 2 diabetes mellitus patients, improve insulin resistance, and enhance islet β-cell function, which is safe and reliable.
		2021 Vol. 28 (36): 47-50 [Abstract] ( 51 ) HTML (36 KB) PDF (0 KB) ( 7 )

	51	Application of "doctor-nurse-patient" three person mode combined with WeChat platform in self management of patients with type 2 diabetes mellitus
		YANG Liping； ZHOU Min； FU Yahong
		Objective To observe the application effect of "doctorl-nurse-patient" management mode combined with WeChat platform on patients with type 2 diabetes.Methods A total of 200 patients with type 2 diabetes mellitus hospitalized in the Second Affiliated Hospital of Nanchang University from March 2020 to December 2020 were selected as the research objects.They were divided into experimental group and control group with 100 cases in each group by random number table method.The control group was managed by routine management, and the experimental group was managed by "doctor -nurse -patient".Fasting blood glucose, glycosylated hemoglobin, self -management ability and quality of life scord were compared between the two groups.Results After intervention, fasting blood glucose and glycosylated hemoglobin in the experimental group were lower than those in the control group, and the differences were statistically significant (P<0.05).After intervention, the score of self-management ability in experimental group was higher than that in control group, and the difference was statistically significant (P<0.05).After intervention, the quality of life score of the experimental group was lower than that of the control group, and the difference was statistically significant (P<0.05).Conclusion The "doctor-nurse-patient" three-person management model can help improve the fasting blood glucose and glycosylated hemoglobin levels of patients with type 2 diabetes, improve self-management ability and quality of life, and has certain clinical application value.
		2021 Vol. 28 (36): 51-53 [Abstract] ( 48 ) HTML (31 KB) PDF (0 KB) ( 8 )

	54	Analysis of related factors of diabetes insipidus after endoscopic transsphenoidal pituitary adenoma resection
		WU Shizhong； WEI De ；LIN Kun； ZHENG Pengfeng
		Objective To explore the related factors of diabetes insipidus after endoscopic transsphenoidal resection of pituitary adenomas.Methods The clinical data of 97 patients with pituitary adenoma who were treated by endoscopic transsphenoidal surgery in Fujian Provincial South Hospital from June 2015 to September 2018 were retrospectively analyzed.Gender, age, tumor size, tumor function, tumor invasion, tumor growth type (whether to break through the saddle diaphragm), tumor resection degree and operation time were selected as possible related factors.The multivariate logistic regression were used to analyze the related factors of postoperative diabetes insipidus.Results Among the 97 patients, 50 cases (51.5%) had postoperative diabetes insipidus.Single factor analysis showed that the difference in tumor growth type and operation duration between the two groups was statistically significant (P<0.05).The multivariate logistic regression analysis showed that suprasellar pituitary adenoma was a risk factor for postoperative diabetes insipidus(P<0.05).Conclusion Tumor growth type is closely related to diabetes insipidus after endoscopic transsphenoidal pituitary adenoma resection, and the risk of diabetes insipidus after suprasellar growth adenoma resection is high.
		2021 Vol. 28 (36): 54-56转60 [Abstract] ( 43 ) HTML (31 KB) PDF (0 KB) ( 7 )

	57	Application and prognosis analysis of single port thoracoscopy in the treatment of early lung cancer
		LIU Kexin
		Objective To investigate the application and prognosis of single port thoracoscopy in the treatment of early lung cancer.Methods A total of 98 lung cancer patients admitted to Tiemei General Hospital of Liaoning Health Industry Group from January 2019 to January 2020 were selected as the research subjects.They were divided by lottery into study group and control group, with 49 patients in each group.The control group was treated with thoracotomy lobectomy, and the study group was treated with single port thoracoscopic surgery.Lung function indexes [first second forced expiratory volume (FEV1), forced vital capacity (FVC), FEV1/FVC], clinical indexes, total incidence of complications, visual analogue scale of pain (VAS) score and quality of life score were compared between two groups.Results After treatment, FEV1, FVC and FEV1/FVC in the study group were higher than those in the control group, the differences were statistically significant (P<0.05).The operative time and hospital stay of the study group were shorter than those of the control group, thoracic drainage was less than that of the control group, and intraoperative blood loss was more than that of the control group, the differences were statistically significant (P<0.05).The total incidence of complications in the study group was lower than that in the control group, the difference was statistically significant (P<0.05).VAS score of the study group was lower than that of the control group after treatment, the difference was statistically significant (P<0.05).The scores of quality of life after treatment in the study group were higher than those in the control group, the differences were statistically significant (P<0.05).Conclusion VATS with single operation hole can shorten the operation time, reduce complications, relieve pain and improve the quality of life of patients with early lung cancer.
		2021 Vol. 28 (36): 57-60 [Abstract] ( 45 ) HTML (32 KB) PDF (0 KB) ( 7 )

	61	Correlation between the expression of regenerative gene 1α, vestigial-like family member 4 and lymph node metastasis in gastric cancer tissue
		LIAN Huojun； WEI Ying； YANG Jing
		Objective To analyze the correlation between the expression of regeneration gene 1α (REG1α), vestigiallike family member 4 (VGLL4) and lymph node metastasis in gastric cancer tissue.Methods A total of 82 patients with gastric cancer admitted to Shangrao People′s Hospital from October 2019 to October 2020 were retrospectively selected as the research objects.According to whether the patients had lymph node metastasis, they were divided into metastasis group (55 cases) and non-metastatic group (27 cases).The positive expression rates of REG1α and VGLL4 were compared between the two groups.And the correlation between the above-mentioned protein expression and lymph node metastasis was analyzed.Results The positive expression rates of REG1α in the metastatic group was significantly higher than that in the non-metastatic group, and the positive expression rate of VGLL4 was lower than that in the nonmetastatic group, the differences were statistically significant (P<0.05).Pearson rank correlation analysis showed that the expression of REG1α was significantly positively correlated with lymph node metastasis of gastric cancer, and the expression of VGLL4 was significantly negatively correlated with lymph node metastasis of gastric cancer (P<0.05).Conclusion REG1α and VGLL4 can be used as effective indicators to assess whether patients with gastric cancer have lymph node metastasis or not, and their expression is related to the lymph node metastasis of gastric cancer.
		2021 Vol. 28 (36): 61-63 [Abstract] ( 47 ) HTML (30 KB) PDF (0 KB) ( 8 )

	64	Study of the psychological elasticity level and influencing factors of patients with lung cancer during radiotherapy
		LIANG Qiaomei； ZHENG Bao； WANG Yaling
		Objective To study the psychological elasticity of patients with lung cancer during radiotherapy and its influencing factors.Methods From March 2020 to March 2021, 80 patients with lung cancer undergoing first radiotherapy in Fuyang Hospital Affiliated to Anhui Medical University were selected as the research subjects.They were divided into the good psychological resilience group (55 cases, CD-RIST≥80 points) and the poor psychological resilience group(25 cases, CD-RIST<80 points) based on the Connor-Davidson resilience scale (CD-RIST) scores.The general baseline data of the two groups were compared.In addition, the correlation between the clinical factors and the low mental resilience and independent factors affecting mental resilience were analyzed.Results There were statistically significant differences in coping style and social support between the two groups (P<0.05).The state of mental resilience was positively correlated with coping style (r=0.364, P=0.025) and social support level (r=4.142, P=0.001).The logistic regression analysis results suggested that negative coping level (β=1.856, OR=3.423, 95%CI=3.132-8.465) and low social support level (β=2.374, OR=3.423, 95%CI=4.245-7.437) were the independent risk factors of the level of mental resilience (P<0.05).Conclusion Patients with poor psychological resilience have more negative coping styles and lower levels of social support than those with good psychological resilience.Negative coping and low levels of social support are independent factors that affect the level of psychological resilience.
		2021 Vol. 28 (36): 64-66 [Abstract] ( 47 ) HTML (29 KB) PDF (0 KB) ( 7 )

	67	Clinicopathological features of Strumal Carcinoid of the ovary
		LIN Yingying；CHEN Zhiwei；ZHANG Huale；YI Huan
		Objective To explore the clinicopathological characteristics of strumal carcinoid of the ovary.Methods Five cases strumal carcinoid of the ovary in Fujian Maternity and Child Health Hospital from September 2010 to September 2020 were selected, and the diagnosis and treatment process, pathological characteristics and Immunophenotype were analyzed retrospectively． The literatures were reviewed.Results The 5 patients were 16 to 57 years old.The main symptoms were pelvic mass, abdominal pain and irregular vaginal bleeding.All of them underwent surgical treatment,the removed ovarian masses were all enlarged and cystic, with a diameter of 6.0 -16.0 cm.Immunohistochemistry showed that synaptophysin (Syn) and and chromogranin A (CgA) all showed positive expression to varying degrees.Thyroglobulin (Tg) was positive in 4 cases and 1 case was negative.Postoperative pathology directly revealed 2 cases of strumal carcinoid of the ovary and 3 cases of carcinoid complicated with mature teratoma.Conclusion Strumal carcinoid of the ovary is very rare, most patients have no typical symptoms, and carcinoid components are mostly mixed with thyroid tissue in teratoma, which is easy to be missed, with characteristic pathological and immunohistochemical characteristics, and a good prognosis.
		2021 Vol. 28 (36): 67-69转76 [Abstract] ( 49 ) HTML (31 KB) PDF (0 KB) ( 8 )

	70	Diagnostic value of multiparameter magnetic resonance image/transrectal ultrasound imaging cognitive fusion targeted puncture biopsy for the diagnosis of prostate cancer
		LIANG Gengqi； TAN Bingchao； GUAN Lixian； LIAO Junfa；XU Xun
		Objective To explore the diagnostic value of multiparameter magnetic resonance image/transrectal ultrasound (mpMRI/TRUS) imaging cognitive fusion targeted puncture biopsy for the diagnosis of prostate cancer.Methods A total of 130 patients with suspected prostate cancer admitted to the Sixth Affiliated Hospital of South China University of Technology from July 2017 to December 2020 were selected retrospectively as the research objects, after mpMRI scanning, TRUS conventional 12-needle systematic puncture biopsy and mpMRI/TRUS imaging cognitive fusion targeted puncture biopsy were performed.The diagnostic value of mpMRI/TRUS imaging cognitive fusion targeted puncture biopsy (specificity, sensitivity, accuracy, positive predictive value, negative predictive value) was observed with the results of conventional 12-needle systematic puncture biopsy as the gold standard.Results The mpMRI/TRUS imaging cognitive fusion targeted puncture biopsy was 79.22% (61/77), sensitivity of 79.25% (42/53), accuracy of 79.23% (103/130), positive prediction of 72.41% (42/58) and negative prediction of 84.72% (61/72).Conclusion The diagnostic efficacy of mpMRI/TRUS imaging is high in medium and high risk prostate cancer and is worthy of clinical application.
		2021 Vol. 28 (36): 70-72 [Abstract] ( 43 ) HTML (32 KB) PDF (0 KB) ( 9 )

	73	Clinical effect of transurethral 1470 nm laser en bloc resection in the treatment of non-muscle invasive bladder cancer
		WU Yigao； ZHAO Yongbin； HU Weilie
		Objective To investigate the clinical effect of transurethral 1470 nm laser en bloc resection in the treatment of non-muscle invasive bladder cancer.Methods The clinical data of 107 patients undergoing non-muscle invasive bladder cancer surgery in Guangdong Hydropower Hospital from January 2017 to January 2020 were retrospectively selected.According to different surgical methods, they were divided into laser group (49 cases) and electric resection group(58 cases).The laser group was treated with transurethral 1470 nm laser en bloc resection, and the electric resection group was treated with transurethral plasma resection.The average operation time, intraoperative blood loss, continuous bladder irrigation time after operation, average hospital stay after operation, the incidence of obturator nerve reflex and bladder perforation and the postoperative tumor recurrence rate index were compared between the two groups.Results The amount of intraoperative blood loss, the duration of postoperative bladder irrigation, the indwelling catheter time,the incidence rate of obturator nerve reflexes, the incidence rate of bladder perforation, the average postoperative hospital stay, and the tumor recurrence rate at 15 months after surgery in the laser group were less than the resection group,and the differences were statistically significant (P<0.05).There was no statistical significance in the operation time and the tumor recurrence rate at 6 months after the operation between the two groups (P<0.05).Conclusion Transurethral 1470 nm laser en bloc resection in the treatment of non-muscle invasive bladder cancer has the advantages of less blood loss, quicker recovery, lower complication rate and low recurrence rate, it is worthy of clinical application.
		2021 Vol. 28 (36): 73-76 [Abstract] ( 55 ) HTML (34 KB) PDF (0 KB) ( 7 )

	77	Observation on the effect of sequential radiochemotherapy and radiochemotherapy in elderly locally advanced non-small cell lung cancer
		CHEN Huan；SHEN Peipei
		Objective To observe the effect of sequential radiochemotherapy and radiochemotherapy in elderly patients with locally advanced non-small cell lung cancer.Methods From July 2020 to March 2021, 80 elderly patients with locally advanced non-small cell lung cancer in the Affiliated Hospital of Jiangnan University were used as the research objects.They were divided into observation group and control group by computer random number method, with 40 cases in each group.patient.The observation group were treated with concurrent chemotherapy and radiotherapy, and the control group were treated with sequential chemotherapy and radiotherapy.The clinical treatment effect, physiological function Karnofsky (KPS) score, the Mos item short form health survey (SF-36) score, and the total incidence of adverse reactions were compared between the two groups.Results The total effective rate of clinical treatment of the observation group was higher than that of the control group, and the difference was statistically significant (P＜0.05).There were no significant differences in the KPS score and SF-36 score of the two groups before treatment (P>0.05);the KPS score and SF-36 score of the two groups after treatment were higher than those before treatment, and the KPS score and SF-36 score of the observation group after treatment were higher than those of the control group, and the differences were statistically significant (P<0.05).There was no statistically significant difference in the total incidence of adverse reactions between the two groups (P>0.05).Conclusion For elderly patients with locally advanced non-small cell lung cancer, concurrent radiotherapy and chemotherapy are more effective in enhancing the efficacy and improving the quality of life of patients, and the program is worth recommending.
		2021 Vol. 28 (36): 77-79转82 [Abstract] ( 45 ) HTML (31 KB) PDF (0 KB) ( 7 )

	80	Influencing factors of chronic cough in patients with non-small cell lung cancer after minimally invasive video-assisted thoracoscopic surgery
		YIN Youhong； RONG Guoxiang ；ZHANG Fan
		Objective To investigate the influencing factors of chronic cough in patients with non-small cell lung cancer (NSCLC) after video-assisted thoracoscopic surgery (VATS).Methods The clinical data of 48 NSCLC patients with chronic cough after VATS surgery in People′s Hospital of Danyang City, Jiangsu Province from January 2018 to December 2020 were retrospectively analyzed and included in the chronic cough group.The clinical data of 48 NSCLC patients without chronic cough after VATS were selected and included in the group without chronic cough.The general data of the two groups were collected and compared to analyze the influencing factors of chronic cough after VATS in NSCLC patients.Results Univariate analysis showed that there were statistically significant differences in preoperative combined cough, surgical resection range, and tracheal intubation time between the chronic cough group and the nonchronic cough group (P<0.05).The results of multivariate analysis indicated that preoperative coughing (β=1.398, OR=4.048, 95%CI=1.125-14.569), surgical resection range of lung lobe (β=2.089, OR=8.077, 95%CI=3.244-20.110), longer tracheal intubation time (β=0.089, OR=1.093, 95%CI=1.052-1.136) were the independent risk factors of chronic cough in NSCLC patients after VATS (P<0.05).Conclusion Chronic cough after VATS in NSCLC patients may be related to preoperative coughing, the scope of surgical resection is the lung lobe and the longer tracheal intubation time.
		2021 Vol. 28 (36): 80-82 [Abstract] ( 38 ) HTML (27 KB) PDF (0 KB) ( 6 )

	83	Effect of individualized early rehabilitation therapy of pelvic floor muscle on postpartum women with different delivery methods
		LIU Yunhua； ZHOU Ping；ZHOU Xia； CHEN Chuping
		Objective To explore the effect of individualized early rehabilitation therapy of pelvic floor muscle on postpartum women with different delivery methods.Methods A total of 122 postpartum women admitted to Baiyun District Shijing People′s Hospital from September 2019 to May 2020 were selected as the research object.According to different delivery methods, they were divided into control group (60 cases) and experimental group (62 cases).The patients in the control group were delivered naturally, and the patients in the experimental group were delivered by cesarean section.The patients in the two groups were treated with individualized early rehabilitation of pelvic floor muscle.The recovery of pelvic floor muscle fiber function, pelvic floor muscle pressure and sexual function were compared between the two groups.Results After treatment, the recovery of pelvic floor muscles and sexual function of the experimental group and the control group were higher than those of this group before treatment, and the differences were statistically significant (P<0.05).After treatment, the pelvic floor muscle fiber function, pelvic floor muscle pressure and sexual function recovery of the experimental group were higher than those of the control group, and the differences were statistically significant (P<0.05).Conclusion Early rehabilitation therapy of pelvic floor muscle is conducive to the recovery of pelvic floor and sexual function on postpartum women, especially for postpartum women with cesarean section.
		2021 Vol. 28 (36): 83-85转89 [Abstract] ( 51 ) HTML (32 KB) PDF (0 KB) ( 6 )

	86	Effect of self-formulated Chinese prescription on the success rate of pregnancy in patients with intrauterine adhesions after hysteroscopy
		FAN Hehua； PENG Saifeng ；LI Lin； YANG Lijuan； LAN Jing； XU Lu； XIAO Aimei
		Objective To explore the effect of self-designed Chinese prescription on the success rate of pregnancy in patients with intrauterine adhesions after hysteroscopy.Methods A total of 80 patients with intrauterine adhesions admitted to Nanchang Institute of Medical Sciences from January 2018 to December 2019 were selected as the study subjects, and were divided into control group (40 cases) and observation group (40 cases) according to the random chart method.The control group was treated with hysteroscopy combined with conventional western medicine.The observation group was treated with hysteroscopic surgery combined with self -prescribed Chinese prescription.The therapeutic effect, degree of adhesion and conception rate were compared between the two groups.Results The total effective rate and pregnancy success rate in observation group were higher than those in control group, and the differences were statistically significant (P<0.05).There was no statistically significant difference in the score of intrauterine adhesion between the two groups before treatment (P>0.05), after treatment, the score of intrauterine adhesion in the two group was lower than that before treatment, and the score of intrauterine adhesion in the observation group was lower than that in the control group after treatment, the difference was statistically significant (P<0.05).Conclusion Adding selfmade Chinese prescription after hysteroscopy can effectively improve the condition of patients with intrauterine adhesions, reduce the degree of adhesions in patients, and significantly improve the success rate of pregnancy, which is worthy of promotion.
		2021 Vol. 28 (36): 86-89 [Abstract] ( 45 ) HTML (34 KB) PDF (0 KB) ( 6 )

	90	Effects of sling exercise therapy on gross exercise in children with motor retardation
		LIU Qiyun； LAI Qing ；XU Kangxin ；ZENG Yuan ；SONG Huanhuan
		Objective To explore the effect of sling exercise therapy on gross exercise in children with motor retardation.Methods From January 2019 to September 2020, a total of 60 children diagnosed with motor development delay admitted to the department of Children′s Rehabilitation, Maternal and Child Health Hospital of Pingxiang were selected as research subjects.They were divided into the control group and the observation group according to the random number table.The control group used conventional comprehensive early intervention training, and in the observation group, sling exercise therapy was added on the basis of the control group.The scores of gross motor function measure scale (GMFM -88) and Peabody developmental motor function scale (PDMS -2) were compared between the two groups.Results Before treatment, the regional A-E scores of GMFM-88 were compared between the two groups, with no statistically significant differences (P>0.05).After treatment, the regional A-E scores of GMFM-88 were higher than those before treatment in the group, with statistically significant differences (P<0.05).After treatment,the regional A～E scores of GMFM-88 of the observation group were higher than those of the control group in the same period, with statistically significant differences (P <0.05).Before treatment, the PDMS -2 score for each item were compared between the two groups, with no statistically significant differences (P>0.05).After treatment, the PDMS-2 score for each item were higher than those before treatment in the group, with statistically significant differences (P<0.05).After treatment, the PDMS-2 score for each item of the observation group were higher than those of the control group in the same period, with statistically significant differences (P<0.05).Conclusion Sling exercise therapy can improve the children′ s motor and neurodevelopment, and meanwhile increase the children′ s compliance.The comprehensive intervention treatment in children with motor retardation can reduce the incidence of neurological abnormalities in the future, improve the ability of motor posture control, and enhance the core muscle strength to promote early recovery of children.
		2021 Vol. 28 (36): 90-93 [Abstract] ( 45 ) HTML (36 KB) PDF (0 KB) ( 8 )

	94	Clinical effect of tubal fenestration on medium and long-term recurrence of ectopic pregnancy
		HU Shuling； YIN Zhangli
		Objective To explore the clinical effect of tubal fenestration on medium and long-term recurrence of ectopic pregnancy.Methods A total of 60 patients with ectopic pregnancy admitted to Nanchang Renai Maternity Hospital from January to December 2019 were selected as the research objects.And divided into the experimental group (n=30) and the control group (n=30) according to the random number table method.The experimental group used fallopian tubes by fenestration for embryos and the control group.The perioperative indicators [operation time, intraoperative blood loss, hospital stay], ovarian hemodynamics (peak systolic velocity [PSV], resistance index [RI], pulsatility index[PI]), and medium-term and long-term follow-up status were compared between the two groups.Results The operation time and hospitalization time in the experimental group were shorter than that in the control group, and the intraoperative bleeding in the experimental group was more than that in the control group, the differences were statistically significant (P<0.05).Before surgery, the PSV, RI, and PI were compared between the two groups, the differences were not significantly significant (P>0.05).After surgery, the PSV in the two groups was higher than that before surgery in the group, and the PSV in the experimental group was higher than that in the control group at the same period, the differences were statistically significant (P<0.05).After surgery, the RI and PI in the two groups were lower than that before surgery in the group, and the RI and PI in the experimental group were lower than those in the control group at the same period, the differences were statistically significant (P<0.05).The postoperative pregnancy rates at 3, 6 months and 1 year was compared between the two groups, the difference was not significantly significant (P>0.05).The intrauterine pregnancy rate at 1 year in the experimental group was higher than that in the control group, the difference was not significantly significant (P<0.05).Conclusion Tubal fenestration for the treatment of ectopic pregnancy patients can improve the intrauterine pregnancy rate, which has little impact on medium and long-term palindromia, which deserves clinical attention.
		2021 Vol. 28 (36): 94-96 [Abstract] ( 52 ) HTML (31 KB) PDF (0 KB) ( 9 )

	97	A clinicopathological study of 4 cases of Cervical adenoid basal carcinoma
		HUANG Zhen； WANG Chengyou； DONG Binhua；LIAO Liu
		Objective To investigate the clinicopathological characteristics of adenoid basal carcinoma of the cervix.Methods The clinicopathological data of 4 ABC patients diagnosed and treated in Fujian Maternity and Child Health Hospital from December 2018 to December 2020 were retrospectively analyzed, and their clinical, histopathological characteristics and immunohistochemical expression were analyzed, and related literatures were reviewed.Results Four patients were 44-66 years old with a median age of 57 years.One patient presented with vaginal contact bleeding, and the other three had no specific symptoms.Three cases of high-risk human papillomavirus were positive, three cases were cytologically diagnosed as squamous intraepithelial lesions (2 cases wre high grade).Two cases underwent total uterus and double appendage (with or without pelvic lymph node dissection) resection, and 2 cases underwent cervical cone resection.Under the microscope, tumor cells were seen in the fibrous stroma of the cervix with nest-like and cord-like infiltrating growth.The cells were small in size, less cytoplasm, and uniform in shape, similar to basal-like cells.The cells around the cancer nests were arranged in a fence.Postoperative pathology, three cases were accompanied by high grade squamous intraepithelial lesions (HSIL), and 1 case was accompanied by cervical squamous cell carcinoma.Four cases of immunohistochemistry were positive for P63, P40, high molecular weight cytokeratin CK (HMW), CK5/6, 3 cases were positive for P16, one case was weakly positive for P53, and the Ki-67 proliferation index was 1%-10%.There were no recurrence or metastasis in 4 cases.Conclusion ABC usually occurs in postmenopausal women.Most of them have no obvious clinical symptoms and are often accompanied by high-risk HPV infections and abnormal cervical cytology.They have characteristic pathological morphology and immunohistochemical characteristics, and a good prognosis.
		2021 Vol. 28 (36): 97-100 [Abstract] ( 56 ) HTML (35 KB) PDF (0 KB) ( 7 )

	101	Application effect of Low Weight Molecular Heparin combined with pregnancy nutrition interference and weight management use in the treatment for gestational metabolic syndrome
		LI Hui； HUANG Li； LIANG Jun
		Objective To investigate the application effect of Low Weight Molecular Heparin combined with pregnancy nutrition interference and weight management use in the treatment for gestational metabolic syndrome.Methods A total of 120 pregnant women with metabolic syndrome during pregnancy who were admitted to the Department of Obstetrics,Zhuzhou People′s Hospital Affiliated to Changsha Medical University from January 2017 to October 2019 were selected as the research subjects.They were divided into treatment group (60 cases) and control group (60 cases) by lotteries.The pregnant women in the control group received routine examination and management of high-risk pregnancy, and the pregnant women in the treatment group received Low Molecular Weight Heparin therapy and nutritional weight management during pregnancy from 24 to 28 weeks of gestation.Platelet, coagulation routine, D-dimer, blood lipid routine indexes and maternal and infant complications were compared between the two groups.Results There were no significant differences in platelet, prothrombin time (PT), D-dimer, triacylglycerol and high-density lipoprotein between the two groups before intervention (P>0.05).After intervention, platelet, PT, D-dimer and triglyceride in the treatment group were lower than those before intervention and lower than those in the control group, while high-density lipoprotein was higher than those before intervention and higher than those in the control group, the differences were statistically significant (P<0.05).The incidence of maternal complications of preeclampsia, cesarean section, postpartum hemorrhage, premature rupture of membranes and polyhydramnios in treatment group was lower than that in control group,the incidence of premature birth, neonatal asphyxia, macrosomia and low birth weight in the treatment group was lower than that in the control group, the differences were statistically significant (P<0.05).Conclusion Low Molecular Weight Heparin combined with nutritional weight management during pregnancy is effective for patients with metabolic syndrome during pregnancy.It can effectively prevent and cure pre-thrombosis, significantly reduce the blood lipid and the incidence of maternal and infant complications, and improve neonatal outcomes.
		2021 Vol. 28 (36): 101-104 [Abstract] ( 52 ) HTML (37 KB) PDF (0 KB) ( 7 )

	105	Application of biofeedback electrical stimulation in the rehabilitation of patients with postpartum pelvic floor dysfunction
		GONG Liping； XIAO Fan
		Objective To explore the clinical application effect of biofeedback electrical stimulation in the rehabilitation of patients with postpartum pelvic floor dysfunction (PFD).Methods A total of 60 patients with PFD after delivery who were admitted to the Department of Obstetrics and Gynecology at the Affiliated Hospital of Jinggangshan University from June 2020 to January 2021 were selected as the research subjects.By a random number table method, the patients were divided into groups A, B, and C with 20 cases in each group.Patients in group A were provided with given aerobics for rehabilitation, batients in group B provided with biofeedback electrical stimulation, and batients in group C were provided with aerobics and biofeedback electrical stimulation.The muscle strength of types I and II muscle fibers and muscle contraction duration, dynamic vaginal pressure, nocturia frequency and quality of life were compared before and after train.Results After train, the patients number of grade IV and V muscle strength of types I and II muscle fibers in group C were higher than those in groups A and B, and the differences were statistically significant (P<0.05),but those indexes in groups A and B were not significant (P>0.05).After train, the contraction duration of types I and II muscle fibers in group C was longer than that of groups A and B with statistical significance (P<0.05).The contraction duration in group B was longer than that of group A with statistical significance (P<0.05).After train, the vaginal pressure of group C was more powerful than that of groups A and B with statistical significance (P<0.05).The vaginal pressure of group B after intervention was more powerful than that of group A with statistical significance (P<0.05).After train, the nocturia frequency and PFIQ-7 scores of group C were lower than groups A and B with statistical significance(P<0.05).The nocturia frequency and PFIQ-7 scores of group B were lower than those of group A, and the differences were statistically significant (P<0.05).Conclusion Both biofeedback electrical stimulation and aerobics can promote the recovery of pelvic floor function.Compared with one of them, combined intervention can significantly improve pelvic floor muscle strength of types I and II muscle fibers, contraction duration, and pelvic floor pressure, thereby effectively promoting the recovery of pelvic floor function and improving quality of life.
		2021 Vol. 28 (36): 105-108 [Abstract] ( 37 ) HTML (36 KB) PDF (0 KB) ( 6 )

	109	Influence of psychological intervention on pregnancy complications and pregnancy outcome of elder pregnant women
		ZHONG Xiaoyan； WANG Sumei ；LIN Mianzhen； JIANG Biwei
		Objective To explore the influence of psychological intervention on pregnancy complications and pregnancy outcome of elder pregnant women.Methods From June 2020 to April 2021, a total of 300 cases of pregnant and lyingin women with advanced age from Huizhou First Maternity and Child Health Hospital were selected as the research objects.They were divided into control group and observation group according to random number table method, with 150 cases in each group.The control group was given routine care, the observation group combined with psychological intervention on the basis of regular standardized management during pregnancy.The Hamilton anxiety scale(HAMA),Hamilton depression scale(HAMD) scores, complications during pregnancy and pregnancy outcome of the two groups of pregnant women were compared.Results The HAMA and HAMD scores of the observation group were lower than those of the control group after treatment, and the differences were statistically significant (P ＜0.05).The incidence of gestational anemia, gestational diabetes, fetal distress, and premature rupture of membranes in the observation group were lower than those in the control group, and the differences were statistically significant (P<0.05).The incidence of premature delivery, macrosomia, and low birth weight among older women in the observation group were lower than those in the control group, the differences were statistically significant (P＜0.05).Conclusion Psychological intervention can relieve the anxiety and depression of elderly pregnant women, reduce the incidence of complications during pregnancy, improve the pregnancy outcome of older pregnant women.It is worthy of clinical promotion.
		2021 Vol. 28 (36): 109-111转115 [Abstract] ( 48 ) HTML (32 KB) PDF (0 KB) ( 7 )

	112	Application effect of Pediatric Feire Kechuan Oral Liquid combined with Azithromycin in children with mycoplasma pneumonia
		WANG Meiyan； GU Lei；CHEN Mengli
		Objective To explore the application effect of Pediatric Feire Kechuan Oral Liquid combined with Azithromycin in children with mycoplasma pneumonia (MPP).Methods A total of 128 children with MPP in Beijing Changping District Hospital from June 2017 to October 2020 were selected as the research objects, and they were divided into the control group (64 cases) and the observation group (64 cases) using the random number table method.The control group was treated with Azithromycin, and the observation group was treated with Pediatric Feire Kechuan Oral Liquid on the basic of the control group.The clinical efficacy, serum inflammatory factor levels, disappearance time of symptoms and signs, and adverse reactions were compared between the two groups.Results The total effective rate of treatment in the observation group was 95.31%, which was higher than 84.38% in the control group, with a statistical difference (P＜0.05).There was no statistical difference in the levels of serum inflammatory factors between the two groups before treatment（P＞0.05）.The levels of interleukin-6 (IL-6), C-reactive protein (CRP) and tumor necrosis factor-α (TNF-α)after treatment in the two groups were lower than before treatment, and the IL-6, CRP and TNF-α level of observation group were lower than those of control group, the differences were statistically significant (P<0.05); the cough time,fever time, chest X-ray lesion disappearance time and lung rales disappearance time of observation group were shorter than those of the control group, the differences were statistically significant (P<0.05); there was no statistically significant difference in adverse reactions between the two groups (P>0.05).Conclusion Pediatric Feire Kechuan Oral Liquid combined with Azithromycin treatment can improve the clinical efficacy of children with MPP, reduce serum IL-6,CRP, and TNF-α levels, accelerate the disappearance of clinical symptoms, which is safe and reliable.
		2021 Vol. 28 (36): 112-115 [Abstract] ( 41 ) HTML (33 KB) PDF (0 KB) ( 8 )

	116	Effect of annular suture of placental plasmomuscular layer combined with B-Lynch uterine binding in the prevention and treatment of postpartum hemorrhage
		ZHU Jinming；MA Chunling； LI Ya′nan；PENG Fengyun；LUAN Xiaomei；LI Yinghui；DU Changjiang； LI Qing
		Objective To investigate the effect of placental sarcomuscular annular suture combined with B-Lynch uterine suture in the prevention and treatment of postpartum hemorrhage.Methods A retrospective analysis was performed on the clinical data of 93 women who underwent cesarean section and delivered in Xuzhou Maternal and Child Health Hospital affiliated to Xuzhou Medical University from January 2020 to June 2021.They were divided into control group(40 cases) and observation group (53 cases) according to the treatment method.The control group was treated with cesarean section combined with B-Lynch uterine suture.Observation group received annular suture in placenta on the basis of control group, and the intraoperative and postoperative blood loss at 24 h were compared between the two groups.Results The intraoperative and 24 h postoperative blood loss in the observation group were lower than those in the control group, and the differences were statistically significant (P＜0.05).Conclusion The annular suture of placental plasmomuscular layer combined with B-Lynch uterine suture can significantly reduce the promote postoperative recovery.
		2021 Vol. 28 (36): 116-118转122 [Abstract] ( 45 ) HTML (32 KB) PDF (0 KB) ( 6 )

	119	Value of vaginal ultrasound combined with serum human chorionic gonadotropin, progesterone, estradiol in early diagnosis of ectopic pregnancy
		SHANGGUAN Yun； LIN Yanbin； LAI Guifeng ；LI Yujuan； HUANG Lin
		Objective To investigate the value of vaginal ultrasound combined with serum human chorionic gonadotropin (β -HCG), progesterone (P) and estradiol (E2) in the early diagnosis of ectopic pregnancy.Methods From May 2017 to August 2021, 34 patients with ectopic pregnancy who were transferred to other hospitals for surgery or follow-up were selected as the observation group, and another 34 patients with normal pregnancy during the same period were selected as the control group.Both groups were examined by transvaginal ultrasound, and blood samples were taken to detect β-HCG, P, E2 indexes, and analyzed the diagnostic efficacy of transvaginal ultrasound and serum indexes.Results The β-hCG, P, E2 index levels of the observation group were lower than those of the control group, and the differences were statistically significant (P＜0.05).The diagnostic coincidence rate of vaginal ultrasound, serum indicators and combined diagnosis was significantly different (P＜0.05).There were statistically significant differences in sensitivity, specificity and accuracy of vaginal ultrasound, serum index and combined diagnosis (P<0.05).And the sensitivity and accuracy of combined diagnosis were higher than those of vaginal ultrasound and serum indexes, and the specificity was higher than those of serum indexes, the differences were statistically significant (P<0.017).The accuracy of vaginal ultrasound was higher than serum index, and the difference was statistically significant (P<0.017).Conclusion The application of vaginal ultrasound combined with serum β-hCG, P, E2 examination in the diagnosis of ectopic pregnancy has certain diagnostic value, which greatly improves the accuracy of clinical diagnosis, avoids missed diagnosis and misdiagnosis, and provides an effective reference for the development of later diagnosis and treatment activities.
		2021 Vol. 28 (36): 119-122 [Abstract] ( 45 ) HTML (34 KB) PDF (0 KB) ( 7 )

	123	Clinical effect of Hexue Mingmu Tablet in the treatment of traumatic hyphema
		LI Xunyi； HE Liangfei； MAO Yujia
		Objective To investigate the clinical effect of Hexue Mingmu Tablet in the treatment of traumatic grade Ⅰand Ⅱhyphema.Methods From January 2017 to July 2020, 46 patients (46 eyes) with traumatic grade Ⅰand Ⅱhyphema in the First Affiliated Hospital of Jiangxi Medical College were selected as the research objects.They were divided into control group (23 cases) and treatment group (23 cases) according to random number table method.The control group was treated with reducing intraocular pressure and topical anti infection, while the treatment group was treated with Hexue Mingmu Tablet on the basis of the control group.The absorption time of hyphema, visual acuity before and after treatment and therapeutic effect were compared between the two groups.Results The absorption time of anterior chamber hemorrhage in the treatment group was shorter than that in the control group, and the difference was statistically significant (P<0.05).Before treatment, the visual acuity between the control group and the treatment group was not statistically significant (P>0.05).After treatment, the visual acuity of the two groups was higher than that before the treatment, and the visual acuity of treatment group was higher than that of the control group, the differences were statistically significant (P<0.05).After treatment, the treatment effect of the treatment group was better than that of the control group, and the difference was statistically significant (P<0.05).Conclusion Hexue Mingmu Tablet in the treatment of traumatic hyphema can accelerate the absorption time of hyphema and improve the visual acuity of patients as soon as possible.
		2021 Vol. 28 (36): 123-125 [Abstract] ( 47 ) HTML (32 KB) PDF (0 KB) ( 7 )

	126	Effect of retrobulbar injection of Triamcinolone Acetonide in the treatment of ischemic optic neuropathy
		CAO Shipei ；XIE Xiaohua ；WU Fangling ；HE Yonghong； ZENG Huan
		Objective To investigate the effect of retrobulbar injection of Triamcinolone Acetonide in the treatment of ischemic optic neuropathy.Methods A total of 88 non arteritic anterior ischemic optic neuropathy （NAION）patients who were admitted to the First People′s Hospital of Nankang District from January to December 2019 were selected as the research objects.They were divided into control group and observation group by random number table method, with 44 cases in each group.The control group received Triamcinolone Acetonide injection next to the superficial temporal artery, and the observation group received Triamcinolone Acetonide injection after the ball.The clinical efficacy, visual recovery and adverse reactions were compared between the two groups.Results The total effective rate of treatment in the observation group was higher than that in the control group, and the difference was statistically significant (P<0.05).The visual acuity level before treatment between the two groups was not statistically significant (P>0.05).The visual field MS levels between the two groups of patients after treatment were higher than those before treatment, and the visual field MS level of observation group was higher than that of the control group, the differences were statistically significant (P<0.05).The best corrected visual acuity, retinal nerve fiber layer thickness, and intraocular pressure of the two groups after treatment were lower than those before treatment, and the intraocular pressure of observation group was lower than that of the control group, the differences were statistically significant (P<0.05).There was no statistically significance in total incidence of adverse reactions between the two groups (P>0.05).Conclusion The retrobulbar injection of Triamcinolone Acetonide in the treatment of NAION is safe and reliable, and can improve the vision of patients.
		2021 Vol. 28 (36): 126-128 [Abstract] ( 50 ) HTML (30 KB) PDF (0 KB) ( 7 )

	129	Clinical effect of iRoot BP Plus in the treatment of open apical lesions of permanent teeth
		WU Jie； WANG Dongmei；YANG Dongqing
		Objective To investigate the clinical effect of iRoot BP Plus in the treatment of open apical lesions of permanent teeth.Methods A total of 52 adult patients with apical foramen unclosed from January 2019 to January 2020 were selected as the research objects in the Department of Dentistry and Endodontics of Shaoguan Stomatological Hospital.Sixty anterior teeth and premolars of the patients were divided into experimental group and control group according to the order of treatment, with 30 teeth in each group.The control group was after the root canal was cleaned, Under the dental microscope, the calcium hydroxide-based root canal paste Vitapex was used for apexplasty.The experimental group filled iRoot BP Plus in the root apical foramen and the lower part of the root canal under the dental microscope.The thickness was about 3～5 mm, and it was hardened.Hot gutta-percha is used to complete the filling of the upper and middle section of the root canal.The number of visits, treatment cycles and treatment effects and incidence of postoperative acute reaction of the two groups of patients were compared.Results The average number of visits and treatment cycles of the experimental group were shorter than those of the control group, and the differences were statistically significant (P<0.05).The success rate of root apex sealing in the experimental group was higher than that in the control group, and the difference was statistically significant (P<0.05).No postoperative acute reaction occurred in both groups.Conclusions iRoot BP Plus apical barrier combined with hot gutta-percha root canal filling is used to treat open apical lesions of permanent teeth.Compared with calcium hydroxide root canal paste Vitapex, apexplasty is significantly less frequent, shorter treatment period, and success rate.High, worthy of clinical promotion.
		2021 Vol. 28 (36): 129-131转135 [Abstract] ( 46 ) HTML (32 KB) PDF (0 KB) ( 7 )

	132	Clinical effect of binocular external rectus recession combined with visual perception training in the treatment of intermittent exotropia in children
		SU Wangming； LI Yanling
		Objective To analyze the clinical effect of binocular external straightening machine recession combined with binocular visual perception training in the treatment of intermittent exotropia in children.Methods A total of 60 children with intermittent exotropia admitted to Longyan Second Hospital from April 2019 to June 2020 were retrospectively selected as the research objects, and divided into control group (30 cases, 30 eyes) and observation group (30 cases,30 eyes) according to treatment methods.The control group was treated with recession of external rectus muscle of both eyes, the observation group was treated with binocular external rectus recession combined with binocular visual perception training.Binocular visual function and recurrence rate of 1 year follow-up were compared between the two groups.Results Before treatment, there was no significant difference in the proportion of children with normal visual function indexes between the two groups (P>0.05).After treatment, the proportion of normal visual function indexes in the two groups was higher than before treatment, and the proportion of normal visual function in the observation group was higher than that in the control group, the difference was statistically significant (P<0.05).The recurrence rate of the observation group was lower than that of the control group after 6 months and 1 year follow-up (P<0.05).Conclusion The binocular external straightening machine recession combined with binocular visual perception training can be used to treat intermittent exotropia in children, which can further improve the therapeutic effect, improve binocular visual function of children ideally, and reduce the rate of disease recurrence.
		2021 Vol. 28 (36): 132-135 [Abstract] ( 41 ) HTML (31 KB) PDF (0 KB) ( 7 )

	136	Application effect comparison of computer aided design/computer aided manufacturing high inlay and traditional impression all ceramic crown in repairing large-area tooth defects
		SUN Benqiang
		Objective To investigate the application effect of computer aided design/computer aided manufacturing(CAD/CAM) high inlay and traditional impression all ceramic crown in the repair of large-area tooth defects.Methods A total of 86 patients with large-area tooth defects treated in the Stomatology Hospital Affiliated to Xiamen Medical College from February 2019 to February 2021 were selected as the research objects.Patients were divided into control group (43 cases) and observation group (43 cases) by random number table method.The control group was repaired with traditional impression all ceramic crown, and the observation group was repaired with CAD/CAM high inlay.They were followed up for 6 months.The restoration effect, periodontal status (plaque index [PLI], periodontal pocket depth [PD],gingival index [GI]), masticatory function and complications were compared between the two groups.Results The color matching degree, surface smoothness, edge tightness and restoration integrity in the observation group were 97.67%,95.35%, 100.00% and 95.35%, respectively, which were higher than 81.40%, 79.07%, 86.05% and 81.40% in the control group, with statistically significant differences (P<0.05).There was no significant difference in periodontal status between the two groups before repair (P>0.05).The PLI, PD and GI of the two groups after repair were lower than those before repair, with statistically significant differences (P<0.05).The PLI ([0.61±0.15] points), PD ([0.77±0.14] mm) and GI ([0.53±0.13] points] in the observation group were lower than those in the control group of (0.73±0.18) points, (1.05±0.21) mm and (0.67±0.16) points, with statistically significant differences (P<0.05).There were no significant differences in bite force and chewing efficiency between the two groups before repair (P>0.05).The bite force and masticatory efficiency of the two groups after repair were higher than those before repair, with statistically significant differences(P<0.05).The bite force ([61.58±6.12] kg) and masticatory efficiency ([89.58±7.13] %) in the observation group were higher than those in the control group of (56.54±5.83) kg and (82.14±6.87)%, with statistically significant differences(P<0.05).The total incidence of complications in the observation group was 4.65%, lower than 18.60% in the control group, the difference was statistically significant (P<0.05).Conclusion CAD/CAM high inlay is more effective in repairing large-area tooth defects.It can improve the repair effect, improve periodontal condition, enhance masticatory function and reduce the incidence of complications after repair.
		2021 Vol. 28 (36): 136-139转142 [Abstract] ( 40 ) HTML (38 KB) PDF (0 KB) ( 6 )

	140	Clinical effect of low temperature plasma radiofrequency ablation on tonsil hypertrophy
		TIAN Ling
		Objective To investigate the clinical effect of low temperature plasma radiofrequency ablation on tonsil hypertrophy.Methods A total of 60 patients with tonsil hypertrophy admitted to Donghai People′s Hospital in Jiangsu Province from December 2018 to December 2019 were selected as the study subjects, and they were divided into observation group (30 cases) and control group (30 cases) by random number table method.The observation group was treated with low temperature plasma radiofrequency ablation, and the control group was treated with tonsillectomy.Operation time, intraoperative blood loss, pain score and complications were compared between the two groups.Results The operation time of observation group was shorter than that of control group, and the amount of intraoperative blood loss was less than that of control group, the differences were statistically significant (P<0.05).The postoperative pain score of the observation group was lower than that of the control group, the difference was statistically significant (P<0.05).The total incidence of postoperative complications in the observation group was 3.3%, lower than 33.3% in the control group, the difference was statistically significant (P<0.05).Conclusion The application of low-temperature plasma radiofrequency ablation in the treatment of tonsillar hypertrophy has good clinical efficacy, and can effectively reduce the operation time and intraoperative bleeding, reduce pain and reduce postoperative complications.It is worthy of clinical promotion and application.
		2021 Vol. 28 (36): 140-142 [Abstract] ( 42 ) HTML (29 KB) PDF (0 KB) ( 8 )

	143	Effect of Escitalopram combined with Mirtazapine on neurological function and levels of 5 -hydroxytryptamine and mammalian target of Rapamycin in patients with post-stroke depression
		LI Xia
		Objective To investigate the effect of Escitalopram combined with Mirtazapine on neurological function and levels of 5-hydroxytryptamine (5-HT) and mammalian target of Rapamycin (mTOR) in patients with post-stroke depression.Methods A total of 62 patients with post-stroke depression admitted to Shangrao Municipal Hospital from July 2019 to December 2020 were selected as the study subjects, and divided into control group (31 cases) and experimental group (31 cases) by random number table method.The control group was treated with Mirtazapine Tablets, and the experimental group was treated with Escitalopram Oxalate Tablets on the basis of the control group.Both groups were treated for 42 consecutive days.The ability of daily living scale (ADL), Pittsburgh sleep quality index (PSQI),Hamilton depression scale (HAMD), National Institutes of Health stroke scale (NIHSS) scores and serum 5-HT, mTOR levels were compared between the two groups before and after treatment.Results Before treatment, there were no significant differences in PSQI, ADL, NIHSS, HAMD scores, serum mTOR and 5-HT levels between the two groups (P>0.05).After treatment, PSQI, NIHSS and HAMD scores in the two groups were lower than those before, and PSQI,NIHSS and HAMD scores in experimental group were lower than those in the control group, with statistically significant differences (P<0.05).The ADL score, serum mTOR and 5-HT levels in the two groups after treatment were higher than those before, and the ADL score, serum mTOR and 5-HT levels in experimental group were higher than those in the control group after treatment, the differences were statistically significant (P<0.05).Conclusion Escitalopram combined with Mirtazapine can improve the daily life ability, sleep quality, depression, nerve function, serum 5-HT, mTOR levels, and improve clinical symptoms, which is worthy of clinical application.
		2021 Vol. 28 (36): 143-145转149 [Abstract] ( 47 ) HTML (34 KB) PDF (0 KB) ( 6 )

	146	Effect comparison of Micronized Progesterone and Dydrogesterone Tablets on abnormal uterine bleeding-ovulatory dysfunction
		YANG Huomei ；SONG Xiaoxia； YANG Qiujuan
		Objective To explore the effect of Micronized Progesterone and Dydrogesterone Tablets on abnormal uterine bleeding-ovulatory dysfunction (AUB-O) and their influences on endocrine function of patients.Methods A total of 117 AUB-O patients admitted to Xinyu People′s Hospital between May 2019 and December 2020 were selected as subjects and divided into group A (n=39), group B (n=39) and group C (n=39) according to random number table method.Group A was treated with Progesterone injection, group B was treated with Micronized Progesterone Capsules,and group C was treated with Dydrogesterone Tablets.The curative effect, changes in levels of endocrine function indexes (luteinizing hormone [LH], serum estradiol [E2], follicle stimulating hormone [FSH]) before and after treatment,and adverse reactions were compared among the three groups.Results There was no significant difference in total clinical effective rate among the three groups (P>0.05).After treatment, the levels of LH, E2, FSH and endometrial thickness in group C were lower than those in group A and group B, and the menstrual volume in group C was lower than that in group A and group B, with statistically significant differences (P<0.05).There were no severe adverse reactions in any group.Conclusion Both Progesterone and Dydrogesterone Tablets can significantly improve endocrine function and endometrial thickness in AUB-O patients, and regulate menstrual volume, with high safety.The improvement effect of Dydrogesterone Tablets is more significant, which is worthy of clinical application and promotion.
		2021 Vol. 28 (36): 146-149 [Abstract] ( 31 ) HTML (36 KB) PDF (0 KB) ( 7 )

	150	Academic characteristics on the treatment of uroschesis of LI Yong-cui in Zhengzhi Huibu
		LIU Jiao
		Uroschesis is equivalent to urinary retention in modern medicine and is one of the common clinical emergencies.Although there are many invasive methods in modern medicine that can treat uroschesis, but there are also many clinical temporary, non-organic changes caused by the uroschesis.Traditional Chinese medicine treatment has distinct advantages, The Zhengzhi Huibu by LI Yong-cui compiled from a summary of his experience in medical practice for many years on the basis of collecting previous classics, the book has a detailed discussion on the etiology, diagnosis, treatment, and medication of various medical and miscellaneous diseases, including uroschesis.This paper mainly analyzes LI Yong-cui′s understanding, diagnosis and treatment of uroschesis.LI Yong-cui believes that the treatment needs evidence identification, evidence treatment, both internal and external treatment, this paper based on the original text of Zhengzhi Huibu combined with the clinical experience of predecessors, the academic thought of LI Yong-cui was summarized and analyzed from the aspects of internal and external factors, external ology, pulse diagnosis, treatment, and prescription medication, in order to provide help for closed clinical diagnosis and treatment.
		2021 Vol. 28 (36): 150-153 [Abstract] ( 31 ) HTML (39 KB) PDF (0 KB) ( 7 )

	154	Preventive effect of traditional Chinese medicine external application on deep vein thrombosis in ICU severe patients
		WANG Zhigang； DU Lijuan； SONG Lu； TANG Hejun； CHEN Xingxian
		Objective To explore the preventive effect of traditional Chinese medicine external application on deep vein thrombosis in ICU severe patients.Methods A total of 128 severe patients admitted to the ICU of Shenzhen Pingle Orthopedics and Injury Hospital from January 2020 to January 2021 were selected as the study subjects, and divided into the control groups (64 cases) and the observation groups (64 cases) according to the random number table method.The control group received anticoagulation treatment, and the observation group applied traditional Chinese medicine on the basis of the control group, the two groups continued medication for 10 days.The blood coagulation function, the blood rheology index and the incidence of the deep vein thrombosis were compared between the two groups.Results Before treatment, the comparison of coagulation function (prothrombin time [PT], activated partial thromboplastin time [APTT],thrombin time [TT], D-dimer [D-D]) were compared between the two groups, with no statistical significant differences(P>0.05).After treatment, PT, APTT, and TT in the two groups were longer than those before treatment in this group,and the D-D levels was lower than that before treatment in this group, and the differences were statistical significant(P<0.05).After treatment, the PT, APTT and TT in the observation group were longer than those in the control group at the same period, and the D-D levels in the observation group was lower than that in the control group at the same period, and the differences were statistical significant (P<0.05).Before treatment, the blood rheological indexes (high blood viscosity [HBV], low blood viscosity [LBV], and plasma viscosity [PV]) were compared between the two groups, with no statistical significant differences (P>0.05).After treatment, the levels of HBV, LBV, and PV in the two groups were lower than those before treatment in this group, and the differences were statistical significant (P<0.05).After treatment,the levels of HBV, LBV, and PV in the observation group were lower than those in the control group at the same period, and the differences were statistical significant (P<0.05).The incidence of deep vein thrombosis in the observation group was lower than that in the control group, and the difference was statistically significant (P<0.05).Conclusion External application of traditional Chinese medicine can improve coagulation function, reduce blood viscosity and reduce severe ICU thrombosis, which is worth extensive application.
		2021 Vol. 28 (36): 154-157 [Abstract] ( 46 ) HTML (36 KB) PDF (0 KB) ( 9 )

	158	Construction and application of cluster management strategy in operating room for thoracoscopic radical resection of lung cancer
		YAO Xiaoyan； LIU Aiping ；WANG Min ；PAN Yan； XU Yarong
		Objective To explore the construction and application of cluster management strategies in the operating room of thoracoscopic radical resection of lung cancer.Methods A total of 106 patients undergoing thoracoscopic radical resection of lung cancer who admitted to Yichun People′s Hospital from November 2019 to December 2020 were selected as research subjects.Patients were divided into control group (53 cases) and observation group (53 cases) by random number table method.The control group used traditional operating room care, and the observation group used operating room cluster management.The operation time, initial out-of-bed activity time, bowel sounds recovery time,length of stay in the hospital and the satisfaction of patients and physicians were compared between the two groups.Results The operation time, initial out-of-bed activity time, the recovery time of bowel sounds and the length of hospital stay of the observation group were shorter than those of the control group, the differences were statistically significant (P<0.05).The satisfaction scores of doctors and patients in the observation group were higher than those in the control group, and the differences were statistically significant (P<0.05).Conclusion Implementing cluster management in the operating room for patients undergoing thoracoscopic radical resection of lung cancer can shorten the surgical treatment time and the patient′s disease recovery process, and at the same time can improve the satisfaction of patients and operating room physicians, and is worthy of application.
		2021 Vol. 28 (36): 158-160转164 [Abstract] ( 40 ) HTML (32 KB) PDF (0 KB) ( 7 )

	161	Application of quality control circle activities in reducing the incidence of ventilator-associated pneumonia
		HUO Wanjun； FENG Suyun； XIONG Xiaoling
		Objective To study the effect of quality control circle (QCC) activity in reducing the incidence of ventilator associated pneumonia (VAP).Methods A total of 285 patients receiving mechanical ventilation in the First Affiliated Hospital of Guangdong Pharmaceutical University from January 2017 to June 2018 were selected as the research subjects, 135 patients admitted from January to September 2017 before the implementation of QCC activities were selected as the control group, and 150 patients admitted from October 2017 to June 2018 after the implementation of QCC activities were selected as the observation group.The control group adopted routine nursing intervention, and the observation group adopted nursing intervention under the quality control circle activities.The incidence of ventilator-associated pneumonia and the implementation rate of hand hygiene, the passing rate of hand hygiene, and the rate of good oral care results were compared between the two groups of patients.At the same time, the time of mechanical ventilation and ICU stay time were recorded.Results The incidence of ventilator-related pneumonia in the observation group was lower than that in the control group, and the difference was statistically significant (P<0.05).The rate of hand hygiene implementation, hand hygiene, and oral care in the observation group were higher than those in the control group, the differences were statistically significant (P<0.001).The mechanical ventilation time and ICU admission time in the observation group were shorter than those in the control group, the differences were statistically significant (P<0.05).Conclusion The implementation of QCC activities will help to reduce the incidence of VAP, improve the overall management of hospital infections and team collaboration.
		2021 Vol. 28 (36): 161-164 [Abstract] ( 43 ) HTML (36 KB) PDF (0 KB) ( 6 )

	165	Application effect of risk management combined with process management in outpatient nursing management
		ZHOU Liwei；CHENG Shiyin； LI Xiaojie
		Objective To explore the application effect of risk management combined with process management in outpatient nursing management.Methods A total of 80 outpatients treated in Xiang′an Hospital of Xiamen University School of Medicine, Xiamen University from November 2019 to November 2020 were selected as the research object.They were divided into control group (40 cases) and observation group (40 cases) by random number table method.The control group was under routine management, and the observation group was under risk management combined with flow management.The patient satisfaction, nursing quality and complaint rate of the two groups were compared.Results The satisfaction of nursing management in the observation group was higher than that in the control group, and the difference was statistically significant (P<0.05).The treatment time, waiting time and registration time in the observation group were shorter than those in the control group, and the differences were statistically significant (P<0.05).The total incidence rate of complaints and doctor-patient disputes in the observation group was lower than that in the control group, and the difference was statistically significant (P<0.05).Conclusion The combination of risk management and process management in outpatient nursing management can improve the effect and quality of nursing management and patient satisfaction, reduce the outpatient complaint rate, and be beneficial to both doctors and patients.
		2021 Vol. 28 (36): 165-167转171 [Abstract] ( 40 ) HTML (34 KB) PDF (0 KB) ( 7 )

	168	Effect of scenario simulation training in orthopedic nursing safety management
		HAN Yanze； HONG Shanshan； MIAO Yu；ZENG Liping
		Objective To explore the effect of scenario simulation training in orthopaedic nursing safety management.Methods A total of 65 patients and 23 nurses in the same period in the 910 Hospital of the Joint Logistics Support Department of the People′s Liberation Army from July 2019 to July 2020 were selected as the control group, and 65 patients and 23 nurses in the same period in the 910 Hospital of the Joint Logistics Support Department of the People′s Liberation Army from August 2020 to August 2021 were selected as the observation group.The training effect, nursing staff work quality, incidence of adverse events and patient satisfaction were compared between the two groups.Results The scores of safety awareness, technical proficiency, demand resolution and communication effects in the training effect of nursing staff in the observation group were higher than those in the control group, and the differences were statistically significant (P<0.05).The scores of drainage tube nursing, posture nursing, medication nursing, and pain nursing in the nursing work quality of the observation group were higher than those of the control group, and the differences were statistically significant (P<0.05).The total incidence of adverse events in the observation group was 3.08%, which was lower than 12.31% in the control group, and the difference was statistically significant (P<0.05).The service attitude,operating technique, condition observation, and patient safety scores of the observation group were higher than those of the control group, and the differences were statistically significant (P＜0.05).Conclusion The application of scenario simulation training in orthopedic nursing safety management can improve the training effect, promote the improvement of nursing quality, reduce the occurrence of adverse events and promote the improvement of nursing satisfaction.
		2021 Vol. 28 (36): 168-171 [Abstract] ( 41 ) HTML (34 KB) PDF (0 KB) ( 6 )

	172	Influence of quality control circle management on work quality of Pharmacy Intravenous Admixture Service Center
		LI Zhe ；JIANG Li ；CUI Zhaoguo； ZHAO Sen
		Objective To use the quality control circle management tools to reduce the human consumption rate of ampoules and improve the work quality of personnel.Methods The data were collected from the registration of ampoule bottle drugs in the pharmacy intravenous admixture service center from January to July 2020, including the number and causes of the loss.The quality control circle circulation management method was used to analyze and continuously improve the problem of ampoule bottle drugs damage.Results Through this quality control circle activity, the ampoule drug loss rate of the intravenous drug compounding center was significantly reduced, and the target achievement rate was 112.78%.The progress rate is 50%.The degree of mastery of the quality control circle, the ability to solve problems, and the degree of enthusiasm were greatly improved, and the activity growth scores were 2.0, 1.6, and 1.0 respectively.Conclusion Quality control circle activities can effectively improve the level of drug administration in centralized drug dispensing centers, and reduce the number of breakage cases in ampoules.
		2021 Vol. 28 (36): 172-175 [Abstract] ( 34 ) HTML (30 KB) PDF (0 KB) ( 7 )

	176	Application of insulation tester in risk management of electrosurgical instruments
		LIU Wei
		Objective To explore the application effect of insulation tester in risk management of electrosurgical instruments.Methods A retrospective analysis was conducted to select 2458 pieces of electrosurgical instruments recovered from the Disinfection Supply Center of Jiangxi Provincial People′s Hospital from April to June 2020 as the control group, including 1931 pieces of operating pliers, 311 pieces of electric coagulation hooks, 135 pieces of power cables,and 81 pieces of other instruments, a total of 60 staff of clinical departments were randomly selected for investigation.In addition, 2510 pieces of electrosurgical instruments recovered from the Disinfection Supply Center of Jiangxi Provincial People′s Hospital from July to September 2020 after the improvement of insulation detection methods were selected as the observation group, including 1952 pieces of operating pliers, 324 pieces of electric coagulation hooks, 147 pieces of power cables and 87 pieces of others, a total of 60 staff of clinical departments were randomly selected for investigation.The total detection rate of insulation damage of electrosurgical instruments was compared between the two groups,and the total satisfaction of the clinical staff was compared between the two groups.Results The total detection rate of electrical surgical instrument insulation damage in the observation group (16.53%) was higher than that in the control group (5.78%), the difference was statistically significant (P<0.05).The total satisfaction of clinical departments in the observation group (100.00%) was higher than that in the control group (91.67%), and the difference was statistically significant (P<0.05).Conclusion In the risk management of electrosurgical instruments, the insulation tester can effectively improve the detection rate of insulation damage, reduce the insulation safety accidents related to electrosurgical instruments, reduce the potential safety hazards, and improve the satisfaction of departments.
		2021 Vol. 28 (36): 176-179 [Abstract] ( 39 ) HTML (34 KB) PDF (0 KB) ( 7 )

	180	Application effect of information management in hospital outpatient management
		DING Bei
		Objective To explore the application effect of hospital information outpatients management.Methods A total of 178 patients in the outpatient department of the Second Affiliated Hospital of Harbin Medical University from June 2019 to June 2021 were selected as the research objects.They were randomly divided into control group (89 cases) and observation group (89 cases).The registration time, waiting time, negative emotion and total satisfaction were compared between the two groups.Results The registration time and queuing time in the observation group were shorter than those in the control group, the scores of self rating anxiety scale (SAS) and self rating depression scale (SDS) were lower than those in the control group, the differences were statistically significant (P＜0.05).The satisfaction of the observation group was 96.63%, which was higher than 88.76% in the control group, the difference was statistically significant (P<0.05).Conclusion Hospital information management can shorten the waiting time of outpatients, alleviate anxiety, depression and other adverse emotions, and improve medical satisfaction.
		2021 Vol. 28 (36): 180-182 [Abstract] ( 42 ) HTML (30 KB) PDF (0 KB) ( 5 )

	183	Reasons and control measures for the interruption of the sterilization cycle of instruments in hydrogen peroxide low -temperature plasma sterilization system
		PENG Yixin； LEI Yiping ；SHI Huan
		Objective To analyze the reasons for the interruption of the sterilization cycle of hydrogen peroxide lowtemperature plasma sterilization system, and explore the corresponding control measures.Methods A retrospective analysis was made of the reasons for the interruption of the sterilization cycle of hydrogen peroxide low-temperature plasma sterilization circulation system in Yichun People′s Hospital from May 2017 to May 2020,and analyze related treatment measures.Results In the 2886 sterilization cycles, the cycle was interrupted 163 times, and the total incidence was 5.65%.The reasons included excessive moisture (52 times, 31.90%), item overload (45 times, 27.61%), irregular placement of items (23 times, 14.11%), sterilization of contraindications (12 times, 7.36%), excessive adsorptive substances (14 times,8.59%), artificial cancellation (7 times, 4.29%) and uncontrollable factors (10 times, 6.13%).Conclusion The interruption of of the sterilization cycle of the hydrogen peroxide low-temperature plasma sterilization system is closely related to the excessive water content of the equipment, item overload, irregular placement of items, tsterilization of contraindications,excessive adsorptive substances, artificial cancellation and uncontrollable factors.The department should standardize the drying, packaging and loading procedures of items to be sterilized, strengthens personnel training, and regularly maintains sterilization equipment to extend the service life of the equipment and reduce operating cost.
		2021 Vol. 28 (36): 183-185转189 [Abstract] ( 43 ) HTML (1 KB) PDF (0 KB) ( 7 )

	186	Application effect of of automatic whole blood component separator in the preparation of concentrated platelets by buffy coat method
		Liang Ruogu； Liang Yanli； Deng Jinlian； Zhang Ying； Gong Huiying； Wu Jianyun
		Objective To explore the application effect of automatic whole blood component separator in the preparation of concentrated platelets by buffy coat method.Methods A total of 108 bags of 400 ml of whole blood collected from Maoming Central Blood Station from January 2020 to December 2020 were selected as the study subjects, and divided into the control group (54 bags) and the experimental group (54 bags) according to the random number table method.The control group was centrifuged at 22℃, concentrated platelets were prepared by the artificial buffy coat method.The experimental group was centrifuged at 22℃, concentrated platelets were prepared by buffy coat method using a fully automated whole blood component separator.The concentrated platelet pass rate, concentrated platelet count and acid base were compared between the two groups.Results The concentrated platelet count in the experimental group was greater than that in the control group, and the difference was statistically significant (P<0.05).The pH value were compared between the two groups, the difference was not statistically significant (P＞0.05).The control red cell count in the experimental group was smaller than that in the control group, and the difference was statistically significant (P<0.05).The qualified rate of concentrated platelets were compared between the two groups, the difference was not statistically significant (P ＞0.05).Conclusion Automatic whole blood component separator in the preparation of concentrated platelets by buffy coat method is better than the artificial method.
		2021 Vol. 28 (36): 186-189 [Abstract] ( 44 ) HTML (32 KB) PDF (0 KB) ( 8 )

	190	Research on the effect of divided classroom application in rehabilitation teaching and its influence on students′ autonomous learning ability and critical thinking
		HAN Peipei； WANG Liyan； CHEN Xiaoyu； GUO Qi
		Objective To explore the effect of divided classroom on the application of rehabilitation teaching and the impact on students′ autonomous learning ability and critical thinking.Methods Sixty-two students from the School of Rehabilitation, Shanghai Health Medical College from February to June 2020 were selected as the control group, and 59 students from September 2020 to January 2021 were selected as the experimental group.The control group used the traditional teaching method for rehabilitation teaching, and the experimental group used the divided classroom for rehabilitation teaching.The assessment scores, independent learning scores and critical thinking ability scores of the two groups were compared.Results The theoretical test scores, operational test scores, and total scores in the final exam of the experimental group were higher than those of the control group, and the differences were statistically significant (P＜0.05).The scores and total scores of each dimension in the self-directed learning readiness scale (SDLRS) of the experimental group, and the differences were statistically significant (P＜0.05).The scores and total scores of all dimensions in the critical thinking disposition inventory (CTDI-CV) of the experimental group were higher than those of the control group, and the differences were statistically significant (P＜0.05).Completion Divided classroom is a kind of teaching method that students have a high degree of recognition, which can improve students′ independent learning ability and critical thinking, thereby improving their test scores.
		2021 Vol. 28 (36): 190-193 [Abstract] ( 46 ) HTML (34 KB) PDF (0 KB) ( 7 )

	194	Practice and thinking of flipped classroom combined with students′ independent small lectures in standardized training of clinical pathology specialists
		CHEN Jun； LI Weiqing； ZHU Shi
		Pathological diagnosis as the "gold standard" of disease diagnosis, provides guarantee for the diagnosis,treatment and prognosis of patients, so the training of talents in clinical pathology has become the focus of recent attention.Will flip combined with students′ small lecture class, under the help of the network information resources, the application in the teaching of the clinical pathology specialist standardization training, training according to the theme of the given class teachers, doctors, independent data access and PPT courseware lecture independently, teachers interact with students after class discussion, unriddling, realize the internalization of knowledge.The results showed that the teaching mode of flipped classroom combined with students′ autonomous small lectures could improve the clinicopathological thinking ability and autonomous learning ability of specialized doctors.The combination of the two could make up for each other′s shortcomings and give full play to their respective advantages.This is a very effective teaching model for clinical pathology training.
		2021 Vol. 28 (36): 194-196转200 [Abstract] ( 35 ) HTML (30 KB) PDF (0 KB) ( 8 )

	197	Application of mini clinical practice assessment teaching method in nursing intern training
		YU Wenhan； ZHU Zhengri； LI Yan； LIU Wanlu；LIU Renjie； XU Ying
		Objective To explore the application effect of mini clinical practice evaluation teaching method in nursing intern training.Methods A total of 46 nursing interns in the Department of Gastroenterology of Hongqi Hospital Affiliated to Mudanjiang University from July 2018 to may 2019 were selected as the research objects.According to the random number table method, they were divided into the observation group and the control group, with 23 cases in each group.The two groups of nursing students were trained in professional theory and nursing skills.The observation group adopted the teaching method combining medical care and mini clinical practice evaluation, and the control group adopted the traditional clinical teaching method of one belt.The internship lasted for 10 months.After the internship,the academic performance, skills assessment, comprehensive ability and satisfaction with the training mode of the two groups were compared.Results The theoretical and skill scores of nursing interns in the observation group were higher than those in the control group, and the differences were statistically significant (P<0.05).The scores of comprehensive ability assessment of nursing interns in the observation group were higher than those in the control group, including nursing procedure application ability, communication and cooperation ability, health education ability, operation skills,autonomous learning ability and professional attitude, the differences were statistically significant (P<0.05).The total satisfaction of nursing interns in the observation group was higher than that in the control group, and the difference was statistically significant (P<0.05).Conclusion The implementation of mini clinical practice evaluation teaching method under the mode of combination of doctors and nurses can significantly improve the theoretical knowledge and skill scores of nursing interns, enhance the comprehensive ability of nursing interns, and improve teaching satisfaction,which is worthy of promotion and use.
		2021 Vol. 28 (36): 197-200 [Abstract] ( 37 ) HTML (36 KB) PDF (0 KB) ( 6 )

	201	Application effect of multidisciplinary vascular access management in the risk prevention of deep vein thrombosis in elderly patients with hip fracture
		WANG Le； HE Ling； XIA Fengmei
		Objective To explore the application effect of multidisciplinary vascular access management in the risk prevention of deep vein thrombosis (DVT) in elderly patients with hip fracture.Methods A total of 200 cases of elderly patients with hip fracture admitted to Jiujiang Hospital of Traditional Chinese Medicine from January 2019 to December 2020 were selected as the research subjects.They were divided into the observation group and the control group by random number table method, 100 cases in each group.Patients in the control group were treated with conventional fracture surgery nursing, while patients in the observation group were treated with multidisciplinary vascular access management on the basis of control group.The knowledge score on prevention of DVT of lower extremity, the occurrence of venous thrombosis including Human sign (+), Nenhof sign (+) and the incidence of DVT, and the hospital stay were compared between the two groups.Results The DVT prevention knowledge pass rate in the observation group was higher than that in the control group, the occurrence of DVT in the observation group was lower than that in the control group, the hospital stay in the observation group was shorter than that in the control group, the differences were statistically significant (P<0.05).Conclusion Applying multidisciplinary vascular access management method in the risk prevention of DVT in elderly patients with hip fracture can predict and evaluate the risks, formulate humanized preventive nursing measures based on the patient′s condition, provide high-quality nursing services to patients and help them recover quickly.
		2021 Vol. 28 (36): 201-203转207 [Abstract] ( 33 ) HTML (32 KB) PDF (0 KB) ( 7 )

	204	Application of problem -based learning teaching combined with SBAR mode in bedside handover of critically ill patients
		DENG Na
		Objective To explore the application effect of problem-based learning (PBL) teaching combined with standardized communication mode (SBAR) in bedside handover of critically ill patients.Methods A total of 120 critically ill patients admitted to Pingxiang People′s Hospital from November 2020 to February 2021 were selected as the research subjects.These patients were divided into the control group (n=60) and the observation group (n=60) according to random number table method.The patients in the control group adopted the SBAR model for nursing handover management, and the patients in the observation group adopted the PBL teaching combined with the SBAR model for nursing handover management.The nurses′mastery of the overall situation of critically ill patients before the intervention and 2 months after the intervention between the two groups were compared.The incidence of handover problems and patients′satisfaction with the handover mode during the intervention period were counted and compared.Critical thinking abilities of two groups of nurses [Chinese version of critical thinking disposition inventory （CTDI-CV）] before the intervention and at the end of the intervention 2 months were compared.Results After 2 months of intervention, the observation group′s nurses mastery scores and CTDI-CV scores of critically ill patients were higher than those of the control group, with statistical differences (P<0.05).During the intervention period, the observation group had a slightly lower rate of handover problems in the control group, without statistical significance (P＞0.05).After the intervention for 2 months, the observation group′s scores for completeness, organization, timeliness, focus and total satisfaction of the handover were higher than those of the control group, with statistical differences (P<0.05).Conclusion The combination of PBL teaching and SBAR mode can be used in bedside handover of critically ill patients.It can improve the patients′overall situation mastery and nurses′critical thinking ability, reduce the incidence of handover problems, and improve patients′ satisfaction with the handover model.
		2021 Vol. 28 (36): 204-207 [Abstract] ( 46 ) HTML (33 KB) PDF (0 KB) ( 7 )

	208	Application of perioperative nursing based on the concept of enhanced recovery after surgery in the postoperative rehabilitation of patients with cervical cancer after radical hysterectomy
		WAN Changgui； TAO Yilei
		Objective To explore the application of perioperative nursing based on the concept of enhanced recovery after surgery (ERAS) in the postoperative rehabilitation of patients with cervical cancer after radical hysterectomy.Methods Sixty-four cervical cancer patients undergoing radical hysterectomy admitted to Third People′s Hospital of Jiujiang City from December 2017 to April 2020 were selected as the research objects, they were divided into control group and experimental group according to random number table method, with 32 cases in each group.The control group received routine nursing intervention, and the experimental group received perioperative nursing intervention based on ERAS concept.The stress response, T lymphocyte levels and postoperative recovery indicators (first exhaust after operation, postoperative ambulation, etc) were compared between the two groups.Results The postoperative ambulation time, first exhaust time, defecation time and postoperative hospital stay in the experimental group were shorter than those in the control group, and the differences were statistically significant (P<0.05).The systolic blood pressure,diastolic blood pressure, mean arterial pressure and heart rate indexes of the experimental group were lower than those of the control group at 10 and 15 minutes after extubation, the differences were statistically significant (P<0.05).The CD3+, CD4+ and CD3+/CD8+ indexes of the experimental group were higher than those of the control group at 1 and 2 d after operation, the differences were statistically significant (P<0.05).The indexes of CD3+, CD4+ and CD3+/CD8+ in the two groups at 1 and 2 d after operation were lower than those at the end of operation, the differences were statistically significant (P<0.05).Conclusion The application of ERAS concept in the perioperative nursing of patients with cervical cancer after radical hysterectomy can reduce postoperative pain and complications, impel patients to recover and return to family and work as soon as possible.
		2021 Vol. 28 (36): 208-211 [Abstract] ( 41 ) HTML (40 KB) PDF (0 KB) ( 6 )

	212	Influence of psychological intervention and health education on the psychological emotion and blood donation reaction of first-time blood donors
		HUANG Xiaoying； OUYANG Jian； HUANG Jianhua；DAI Lin
		Objective To explore the effect of psychological intervention combined with health education on the psychological emotion and blood donation reaction of first-time blood donors.Methods A total of 10 642 cases of firsttime blood donors in Guangzhou Blood Center from October 2019 to December 2020 were selected as the research objects and divided into the control group (5321 cases) and the observation group (5321 cases) according to random number table method.The control group was given routine nursing care, and the observation group was given psychological intervention and health education.The two groups of blood donors before and after the intervention of psychological and emotional situation and adverse reactions after blood donation were compared.Results The scores of self rating depression scale (SDS) and self rating anxiety scale (SAS) in the observation group were lower than those in the control group after intervention (P＜0.05）.After the intervention, the scores of adult version of mental health continuum short form(MHC-SF) in the observation group were higher than those in the control group; the incidence of adverse reactions in the observation group was lower than that in the control group, the differences were statistically significant (P<0.05).Conclusion Psychological intervention combined with health education can effectively relieve the tension and anxiety of first-time blood donors, make blood donors maintain a good positive health mood, help to reduce the incidence of blood donation reaction, and promote the good development of blood donation.
		2021 Vol. 28 (36): 212-214 [Abstract] ( 44 ) HTML (31 KB) PDF (0 KB) ( 7 )

	215	Application effect of postoperative catheter extubation system in common diseases of urology
		MIAO Xiaohong ；LIU Xueting； LIAO Zhenzhen
		Objective To investigate the clinical application of the catheter extubation system in the common diseases of urology.Methods A total of 120 patients admitted to Department of Urology of Xingang Central Hospital from January 2020 to January 2021 were selected as the research objects, they were divided into control group and observation group according to random number table method, with 60 cases in each group.The control group was given routine nursing, and the observation group was given postoperative catheter extubation system on the basis of the control group.Results The success rate of self micturition and induced micturition in the observation group were higher than those in the control group, the differences were statistically significant (P<0.05).The indwelling time of urinary catheter of the observation group was shorter than that of the control group, the urinary tract infection rate and unreasonable use rate of urinary catheter of the observation group were lower than those of the control group, the differences were statistically significant (P<0.05).The nursing total satisfaction rate of the observation group was higher than that of the control group, the difference was statistically significant (P<0.05).Conclusion The urinary postoperative catheter extubation system can effectively shorten the indwelling time of urinary catheter, reduce the risk of infection, which has the value of popularization.
		2021 Vol. 28 (36): 215-218 [Abstract] ( 45 ) HTML (35 KB) PDF (0 KB) ( 7 )

	219	Effect of narrative nursing on the emotions and self-acceptance of patients with depression
		ZHONG Liuyan； LI Cailing； WU Xianka
		Objective To explore the effect of narrative nursing on the emotions and self-acceptance of patients with depression.Methods A total of 100 patients with depression admitted to Meizhou Third People′s Hospital from June 2019 to January 2021 were selected as the research objects, they were divided into control group and observation group according to random number table method, with 50 cases in each group.The control group was given routine nursing intervention, and the observation group was given narrative nursing intervention.The scores of Hamilton depression scale (HAMD), Hamilton anxiety scale (HAMA) and self acceptance questionnaire (SAQ) were compared between the two groups at admission and 1, 2 and 4 weeks after hospitalization, the nursing total satisfaction of the two groups after intervention were compared.Results The HAMD and HAMA scores of the observation group at 1, 2 and 4 weeks after hospitalization were lower than those of the control group, the differences were statistically significant (P<0.05).The SAQ scores of the observation group at 1, 2 and 4 weeks after hospitalization were lower than those of the control group, the differences were statistically significant (P<0.05).The nursing total satisfaction of the observation group was higher than that of the control group, the difference was statistically significant (P<0.05).Conclusion The use of narrative nursing to intervene patients with depression can significantly eliminate the patients′ negative emotions such as depression and anxiety, improve their self-acceptance, ensure the quality of clinical care, and make patients more satisfied.
		2021 Vol. 28 (36): 219-222 [Abstract] ( 44 ) HTML (37 KB) PDF (0 KB) ( 7 )

	223	Effect of psychological nursing in operating room on emotional status of patients with ectopic pregnancy during laparoscopic operation
		PENG Xuelian； WANG Guilan； ZHAO Shuping； XIE Rong； WANG Xiulan
		Objective To explore the effect of psychological nursing in operating room on the emotional status of patients with ectopic pregnancy during laparoscopy.Methods A total of 60 patients with ectopic pregnancy who underwent laparoscopic surgery in Ji′an Central People′s Hospital from January 2019 to April 2021 were selected as the research objects.They were divided into the observation group and the control group according to random number table method, 30 cases in each group.Both groups received laparoscopic surgery, the control group received routine perioperative nursing, and the observation group received psychological nursing in the operating room.The scores of self rating anxiety scale (SAS) and self rating depression scales (SDS), recovery time of gastrointestinal function, length of hospital stay, postoperative complications and nursing satisfaction at discharge were compared between the two groups before and after nursing intervention.Results The SAS and SDS score of the observation group were lower than those of the control group, the differences were statistically significant (P<0.05).The recovery time of gastrointestinal function and hospital stay in the observation group were shorter than those in the control group; the total incidence of postoperative complications in the observation group was lower than that in the control group, the total satisfaction of nursing in the observation group was higher than that in the control group, the differences were statistically significant (P<0.05).Conclusion Psychological nursing in the operating room has a positive impact on the emotional status of patients with ectopic pregnancy during laparoscopic surgery.It can improve the emotional status of patients, shorten the postoperative recovery time, reduce the risk of complications, and improve the nursing satisfaction of patients as a whole.
		2021 Vol. 28 (36): 223-225转229 [Abstract] ( 49 ) HTML (33 KB) PDF (0 KB) ( 7 )

	226	Implementation effect of high-quality nursing cooperation mode in nursing of patients undergoing gastroscopic electroresection of gastric polyps
		WU Mei
		Objective To explore the clinical effect of high-quality nursing cooperation in the nursing of patients undergoing gastroscopic electroresection of gastric polyps.Methods A total of 62 patients with gastric polyps removed under gastroscopy from January to December 2019 in Fuzhou First People′s Hospital of Jiangxi Province were selected and divided into observation group and control group according to random number table method, with 31 cases in each group.The observation group received high-quality nursing cooperation intervention, and the control group received routine nursing.Perioperative related indicators of the two groups were evaluated.Results The time of postoperative anal exhaust and time of ambulation in the observation group were earlier than those in the control group, the differences were statistically significant (P<0.05).The incidence of complications in observation group was lower than control group, nursing satisfaction was higher than that in control group, the differences were statistically significant (P<0.05).Face, avoidance and yield scores in the observation group were higher than those in the control group after nursing, the differences were statistically significant (P<0.05).Conclusion In the perioperative nursing intervention stage of patients undergoing gastroscopic electroresection of gastric polyps, the implementation of high-quality nursing mode can help to promote rehabilitation, reduce the trauma of patients undergoing gastroscopic electroresection, eliminate adverse emotions, and achieve the purpose of promoting rehabilitation, which has significant advantages.
		2021 Vol. 28 (36): 226-229 [Abstract] ( 45 ) HTML (32 KB) PDF (0 KB) ( 8 )

	230	Application effect of family -based extended rehabilitation nursing measures in patients after acute myocardial infarction
		LOU Wenting； HOU Qiuyang； MENG Weihong
		Objective Discussion of the application effect of family-based extended rehabilitation nursing measures in patients after acute myocardial infarction (AMI).Methods The 100 patients with AMI admitted to Benxi Central Hospital from May 2019 to May 2020 were selected as the study objects.The randomized digital table divided patients into the observation group (50 cases) and the control group (50 cases).The control group adopted routine nursing method,and the observation group adopted family-based extended rehabilitation nursing method, the sleep quality before and after care was compared.Results Before nursing, the sleep quality was no difference between the two groups (P＞0.05),the score of subjective sleep quality, sleep time, sleep time, sleep efficiency and others were lower than those in the control group, the differences were statistically significant (P<0.05).The medication, regular exercise, reasonable diet,self-monitoring and regular review were higher than that of the control group, the differences were statistically significant (P<0.05).Conclusion The application of family-based extended rehabilitation nursing measures for patients after AMI can significantly improve their sleep quality, be conducive to the cure of patients ′disease, and deserve clinical promotion and use.
		2021 Vol. 28 (36): 230-233 [Abstract] ( 47 ) HTML (36 KB) PDF (0 KB) ( 7 )

	234	Application effect of intelligent negative pressure combined with autologous platelet-rich gel in Wagner 3-4 grade diabetic foot
		FENG Huiping； ZHANG Quan； HUANG Juanhua； YANG Pijian▲
		Objective To explore the effect of intelligent negative pressure combined with autologous platelet-rich gel on Wagner 3-4 grade diabetic foot.Methods A total of 80 patients with Wagner 3-4 grade diabetic foot hospitalized in Qinzhou First People′s Hospital from February 2020 to May 2021 were divided into experimental group and control group according to random number table method, with 40 cases in each group.Patients in the control group were treated with intelligent trauma negative pressure comprehensive therapy, patients in the experimental group were treated with intelligent trauma negative pressure combined with autologous platelet-rich gel.The wound healing time, dressing change time, ulcer area, blood glucose level, treatment effect and treatment satisfaction were compared between the two groups.Results The time of dressing change, ulcer area in the experimental group were less than those in the control group, healing time was shorter than that in the control group, and blood glucose level was lower than that in the control group after 4 weeks of treatment, the differences were statistically significant (P<0.05).The total effective rate of the experimental group was higher than that of the control group, the difference was statistically significant (P<0.05).The satisfaction of the experimental group after 4 weeks of treatment was higher than that of the control group, the difference was statistically significant (P<0.05).Conclusion Treatment of Wagner 3-4 diabetic foot by intelligent negative pressure combined with autologous platelet-rich gel can effectively relieve clinical symptoms, reduce ulcer area, promote wound healing, shorten hospital stay and improve satisfaction.It has simple operation and low cost, which is worthy of popularization and application.
		2021 Vol. 28 (36): 234-236转240 [Abstract] ( 44 ) HTML (33 KB) PDF (0 KB) ( 7 )

	237	Effect of clinical comprehensive high-quality nursing on patients with viral myocarditis treated by extracorporeal membrane oxygenation
		SUN Lingling； LIU Jianfeng
		Objective To explore the application effect of clinical comprehensive high-quality nursing in the treatment of patients with viral myocarditis by extracorporeal membrane oxygenation (ECMO).Methods A total of 48 patients with viral myocarditis admitted to the First Affiliated Hospital of Xiamen University from August 2018 to August 2020 were selected as clinical research objects, they were divided into comprehensive group and control group according to random number table method, with 24 cases in each group.Patients in the two groups were treated with ECMO, patients in the comprehensive group were given comprehensive high-quality care, and patients in the control group were given routine care.The differences in the levels of myocardial enzyme spectrum and cardiac function indexes were compared between the two groups after 2 months of nursing.Results There was no statistical significance in the levels of myocardial enzymes and cardiac function indexes between the two groups before nursing (P>0.05).After 2 months of nursing, the levels of myocardial enzymes in the comprehensive group were lower than those in the control group, the level of cardiac function in the comprehensive group was higher than that in the control group, the differences were statistically significant (P<0.05).After 2 months of nursing, the levels of myocardial enzymes in the two groups were lower than those before nursing, and the levels of cardiac function indexes in the two groups were higher than those before nursing, the differences were statistically significant (P<0.05).Conclusion Comprehensive high-quality care for patients with viral myocarditis undergoing ECMO treatment has significant clinical effects, which can significantly improve the heart function of patients, and it is recommended to be applied and promoted.
		2021 Vol. 28 (36): 237-240 [Abstract] ( 33 ) HTML (31 KB) PDF (0 KB) ( 7 )

Copyright © Editorial Board of 中国当代医药
Supported by:Beijing Magtech