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Quick Search     Adv Search 2021 Vol. 28, No. 35 Published: 2021-12-18   7 Correlation of ursolic acid against liver fibrosis with Ang Ⅱ/AT1R signaling pathway CHEN Tao1 LIU Cong2 WAN Si-zhe2 ZHU Xuan2▲ Objective To analyze the anti-fibrotic effect of ursolic acid (UA) and its underlying mechanism based on the Ang Ⅱ/AT1R signaling pathway. Methods Forty SD rats were randomly divided into control group, model group,perindopril group and UA intervention group, with 10 rats in each group. Rats in control group were given olive oil intragastric administration, and rats in model group were induced by carbon tetrachloride solution (CCl4) to construct hepatic fibrosis model, Perindopril group and UA intervention group were given perindopril and UA respectively by intragastric administration on the basis of constructing hepatic fibrosis model of SD rats. Liver histopathology was observed by HE staining, and collagen deposition in liver was observed by Sirius red staining. Serum glutamic-oxalacetic transaminase, glutamic-pyruvic transaminase and serum total bilirubin expression levels were detected using kits. The protein expression levels of Ang Ⅱ, AT1R, Collagen Ⅰ and α -smooth muscle actin (α-SMA) in liver were detected by western blot. The mRNA expression levels of Ang Ⅱ, AT1R, Collagen Ⅰ and α-SMA were detected by real-time fluorescence quantitative polymerase chain reaction. Liver slices were scored by METAVIR hepatic fibrosis scoring system. Results The degree of inflammatory cell infiltration, balloon-like change and collagen deposition of liver in model group were higher than those in control group, the necrosis area of liver cells in the perindopril group and UA intervention group was lower than that in the model group. METAVIR score in model group was higher than that in control group, Perindopril group and UA intervention group, the differences were statistically significant(P＜0.05). The expression levels of serum aspartate aminotransferase (AST), alanine aminotransferase (ALT) and total bilirubin (TBil) in model group were higher than those in control group, Perindopril group and UA intervention group,the differences were statistically significant (P＜0.05). The expressions of Ang Ⅱ, AT1R, Collagen Ⅰ and α-SMA proteins in liver of model group were higher than those in control group, Perindopril group and UA intervention group, the differences were statistically significant (P＜0.05). Conclusion UA has anti-fibrosis effect, which can significantly reduce liver inflammation, collagen deposition, and significantly alleviate the progression of liver fibrosis, which may be related to the Ang Ⅱ/AT1R signaling pathway. UA is expected to become a drug candidate for anti-fibrosis targeting the Ang Ⅱ/AT1R signaling pathway in the future. 2021 Vol. 28 (35): 7-11 [Abstract] ( 42 ) HTML (42 KB)  PDF  (0 KB)  ( 6 ) 12 Observation of curative effect of selective constriction of peripheral nerve combined with rehabilitation of traditional Chinese medicine on spastic cerebral palsy ZHONG Li-wei CHEN Si-si TAN Zheng-hua Objective To investigate the effect of selective constriction of the peripheral nerve combined with rehabilitation of traditional Chinese medicine in children with spastic cerebral palsy. Methods A total of 64 children with spastic cerebral palsy who were admitted to Jiujiang Hospital of Traditional Chinese Medicine from July 2019 to January 2020 were selected as the research subjects, and they were divided into the control group (32 cases) and the treatment group (32 cases) by the random number table method. The control group was treated with selective constriction of the peripheral nerve combined with conventional rehabilitation, and the treatment group was treated with selective constriction of the peripheral nerve combined with traditional Chinese medicine rehabilitation. Both groups were treated for 3 months continuously. The clinical efficacy of the two groups was observed after 3 months of treatment, and the muscle tension of the affected limbs was observed before treatment, at the end of treatment and at 1, 6 and 12 months after treatment. Results The total effective rate of the treatment group was higher than that of the control group, and the difference was statistically significant (P＜0.05). At the end of treatment and at 1, 6 and 12 months after treatment, the scores of muscle tension in the two groups were lower than those before treatment, and the scores in the treatment group were lower than those in the control group, with statistically significant differences (P＜0.05). Conclusion Selective constriction of the peripheral nerve combined with rehabilitation of traditional Chinese medicine can reduce muscle tension in children with spastic cerebral palsy, which has significant clinical effect. 2021 Vol. 28 (35): 12-14转18 [Abstract] ( 41 ) HTML (31 KB)  PDF  (0 KB)  ( 6 ) 15 Influence of Progesterone on Progesterone and prognosis of threatened abortion caused by luteal insufficiency WAN Chang-gui TAO Yi-lei▲ Objective To study the effect of different dosage forms of Progesterone (P) on progesterone and prognosis of pregnant women with threatened abortion caused by luteal insufficiency. Methods From February 2019 to February 2020, 58 patients with threatened abortion due to corpus luteal insufficiency treated by the Third People′s Hospital of Jiujiang City were selected as the research objects. According to the envelope sealing method, they were divided into observation group and control group, with 29 cases in each group. The observation group was treated with oral Progesterone, and the control group was treated with intramuscular injection of Progesterone, with 10 days. The efficacy, P,serum β-human chorionic gonadotropin (β-hCG), serum cytokine levels, progesterone-induced blocking factor levels(PIBF) and the success rate of pregnancy loss were compared between the two groups. Results There was no statistically significant difference in total clinical effective rate between the two groups (P＞0.05). After treatment, the levels of P,β-hCG and PIBF in observation group were higher than those in control group, and the differences were statistically significant (P＜0.05). There was no statistically significant difference in the success rate of fetal preservation between the two groups (P＞0.05). After treatment, the level of interferon-γ (IFN-γ) in observation group was lower than that of the control group, and the levels of interleukin-4 (IL-4), interleukin-8 (IL-8) and regulated upon activation normal T cell expressed and secreted factor (RANTES) were higher than those of the control group, the differences were statistically significant (P＜0.05). Conclusion Oral and intramuscular injection of Progesterone in the treatment of threatened abortion due to luteal insufficiency has little difference in effect, but the treatment is convenient and can promote the return of reproductive hormones to normal. Clinically, appropriate medication can be adopted according to the actual situation of puerpera. 2021 Vol. 28 (35): 15-18 [Abstract] ( 41 ) HTML (33 KB)  PDF  (0 KB)  ( 5 ) 19 Effects of different anesthesia depths under closed circle target-controlled infusion on intraoperative hemodynamics and postoperative cognitive dysfunction in elderly patients under general anesthesia NI Lin-hua Objective To investigate the effects of different anesthesia depths under closed circle target-controlled infusion on intraoperative hemodynamics and postoperative cognitive dysfunction in elderly patients under general anesthesia. Methods Eighty elderly patients who underwent elective general anesthesia in Affiliated Hospital of Xuzhou Medical University from January 2018 to January 2021 were selected and divided into the observation group (40 cases)and the control group (40 cases) according to the random number table method. The control group was given general anesthesia with BIS 45 under closed target-controlled infusion. In the observation group, BIS was set at 55 under closed loop target controlled infusion for general anesthesia. Intraoperative hemodynamics at different times (Immediate after intubation [T1], 20 min [T2]after the start of surgery, 60 min [T3]after the start of surgery, 100 min after the start of surgery [T4], and immediate extraction of the tracheal catheter [T5]) and postoperative cognitive dysfunction at different times were compared between the two groups. Results The heart rate (HR) of the observation group at T2, T3, T4 was higher than that at T1 in the group, with statistically significant difference (P＜0.05). The mean arterial pressure (MAP)the observation group at T2, T3, T4, T5 was higher than that at T1 in the group, with statistically significant difference (P＜0.05). The HR and MAP of the control group at T2, T3, T4, T5 were higher than those at T1 in the group, with statistically significant differences (P＜0.05). The HR of the observation group at T1, T3, T5 was lower than that of the control group in the same period, with statistically significant difference (P＜0.05). The MAP of the observation group at T1 was higher than that of the control group in the same period, with statistically significant difference (P＜0.05). The MAP of the observation group at T5 was lower than that of the control group in the same period, with statistically significant difference (P＜0.05). There was no tatistically significant difference in mini-mental state examination (MMSE) score of the observation group between 1 day after surgery and 2, 3, 7 days after surgery (P＞0.05). The MMSE score of the control group on 2, 3, 7 days after surgery was higher than that on 1 day after surgery in the group, with statistically significant difference (P＜0.05). The MMSE score of the observation group on 1,2 days after surgery was higher than that of the control group in the same period,with statistically significant difference(P＜0.05). There was no tatistically significant difference in MMSE score of the two groups were compared on 1, 2 days after surgery (P＞0.05). Conclusion Deep anesthesia under closed loop target-controlled infusion can promote the stability of hemodynamics and the recovery of postoperative cognitive function in elderly patients with general anesthesia. 2021 Vol. 28 (35): 19-22 [Abstract] ( 34 ) HTML (42 KB)  PDF  (0 KB)  ( 8 ) 23 Application effect of Levosimendan combined with Enalapril in patients with heart failure in lowering ejection fraction ZHENG Jie ZHANG Qi-hua Objective To explore the effect of Levosimendan combined with Enalapril in patients with heart failure(HFrEF) in reducing ejection fraction. Methods From January 2016 to January 2020, 125 patients with HFrEF admitted to the Department of Cardiology, Miyun District Hospital, Beijing were selected as the research subjects, and they were divided into observation groups according to the odd and even numbers of the consultation number (n=63, the number of visit was singular) and control group (n=62, the number of visits was even). The control group received conventional treatment and Enalapril treatment at the same time. The observation group added Levosimendan treatment on the basis of the control group. The levels of serum brain natriuretic peptide (BNP), cardiac ultrasonic measurement parameters before and after treatment, and the incidence of adverse reactions and clinical efficacy were compared between the two groups. Results The total effective rate after treatment in the observation group was higher than that in the control group, and the difference was statistically significant (P＜0.05). After treatment, the BNP level of the observation group was lower than that of the control group, and the difference was statistically significant (P＜0.05). After treatment, the left ventricular ejection fraction and left ventricular fractional shortening of the observation group were higher than those of the control group, and the difference was statistically significant (P＜0.05). There was no significant difference in the total incidence of adverse reactions between the the two groups (P＞0.05). Conclusion Levosimendan combined with Enalapril in the treatment of HFrEF can improve the therapeutic effect, reduce the BNP level, improve the parameters of the patient′s cardiac ultrasound detection, and it doesn′t increase the incidence of adverse reactions. 2021 Vol. 28 (35): 23-26 [Abstract] ( 42 ) HTML (36 KB)  PDF  (0 KB)  ( 6 ) 27 Research progress of vaginal flora and the occurrence and development of cervical cancer XIAO Wen-yuan HE Jun-xia LI Jia-qi ZHAO Jin▲ Cervical cancer is one of the most common malignant tumors in women, and the vaginal flora plays an important role in the occurrence and development of cervical cancer. Under the action of various risk factors, the number of lactobacilli in the vaginal flora decreases, and anaerobic bacteria replace lactobacilli as the dominant flora, which will lead to the occurrence of bacterial vaginosis, which is conducive to high-risk human papillomavirus persistent infection and cervical epithelium. The internal neoplasia even gradually develops to cervical cancer.This article reviews the relationship between the vaginal flora and the occurrence and development of cervical cancer, and aims to guide the clinical application of gynecology to better and rationally use drugs, maintain the stable balance of vaginal flora, and prevent the occurrence of cervical cancer. 2021 Vol. 28 (35): 27-30 [Abstract] ( 45 ) HTML (38 KB)  PDF  (0 KB)  ( 7 ) 31 The research progress on Continuous Home Care for Chronic obstructive pulmonary disease patients in the context of Internet Plus ZHOU Xiao-ling1 ZHOU Shu-jian2 ZHENG Yu-hong1 The article illustrates the concepts of “internet plus”, “continuous nursing” and “home care”. And then it makes a review on the current research status of continuous home care for chronic obstructive pulmonary disease(COPD) patients in the context of internet plus at home and abroad, including the necessity of providing outside hospitals continuous home care for COPD patients, the status of COPD patients’ demand for continuous home care, the content of this demand, main models, the formal of internet plus services, the evaluation of implementation and effects and the existential problems. It provides references to build and implement standardized continuous home care service models for COPD patients in the context of internet plus. 2021 Vol. 28 (35): 31-35 [Abstract] ( 44 ) HTML (47 KB)  PDF  (0 KB)  ( 6 ) 36 Prospective and randomized controlled Rhubarb Soaking Solution combined with Indomethacin Suppository in preventing pancreatitis after ERCP FU Yun-hui GONG Min LI Xing HAN Ming LAI Li-xia Objective To explore the application value of Rhubarb Soaking Solution combined with Indomethacin Suppository in the prevention of pancreatitis (PEP) after endoscopic retrograde cholangiopancreatography (ERCP). Methods A total of 160 patients undergoing ERCP who were admitted to the Jiangxi Pingxiang People′s Hospital from January 2019 to January 2021 were selected as the research subjects, the random number table was used to divide them into a control group and a study group with 80 cases each. Patients in the control group received conventional treatment combined with Indomethacin Suppository 30 min before operation, and in the study group, patients received conventional treatment combined with Indomethacin Suppository 30 min before operation and Rhubarb Soaking Solution in oral administration after surgery. The degree of abdominal pain, laboratory examination indexes, rehabilitation effect, PEP and the incidence of hyperamylaseemia were compared between the two groups. Results The degree of abdominal pain in the study group was milder than that in the control group, and the difference was statistically significant (P＜0.05).There were no significant difference in alanine aminotransferase (ALT), serum total bilirubin (TBil), and C-reaction before (CRP), or serum amylase (AMS) level before treatment in the two groups (P＞0.05). The ALT, TBil, CRP, and AMS levels of patients in the study group after treatment were lower than those of the control group, and the differences were statistically significant (P＜0.05). In the study group, the time of anal exhaust, defecation, and nausea and vomiting disappearing, and hospital stay were shorter than the control group, and the differences were statistically significant (P＜0.05). The incidence of PEP and hyperamylaseemia in the study group were lower than those in the control group, and the differences were statistically significant (P ＜0.05). Conclusion Rhubarb Soaking Solution combined with Indomethacin Suppository can effectively prevent the occurrence of PEP, relieve abdominal pain, protect liver function,reduce AMS level, and promote postoperative recovery. 2021 Vol. 28 (35): 36-39 [Abstract] ( 43 ) HTML (36 KB)  PDF  (0 KB)  ( 7 ) 40 Application value of early abdominal paracentesis drainage in severe acute pancreatitis SONG Jia-cai TANG Yi CAI Long CHEN Ying ZHANG Hui-lin TU Jiang-tao LIU Yi-jun NIE Feng Objective To analyze the application value of early abdominal paracentesis drainage (APD) in severe acute pancreatitis (SAP). Methods A total of 94 patients with SAP admitted to Yichun People′s Hospital between January 2018 and November 2020 were enrolled and divided into control group (47 cases) and observation group (47 cases) by simple number table method. The control group was given routine treatment regimens, the observation group underwent early APD on basis of control group. The stay time in ICU, mechanical ventilation time and levels of laboratory test indexes were compared between the two groups. Results The length of ICU hospitalization and mechanical ventilation in the observation group were shorter than those in the control group, and the differences were statistically significant (P＜0.05).After treatment,the observation group′s blood glucose, procalcitonin (PCT), the arterial blood lactic acid level were lower than those of the control group, C-reactive protein (CRP) was higher than that of the control group, the differences were statistically significant (P＜0.05). After treatment, the blood calcium level of the observation group was higher than that of the control group, the difference was statistically significant (P＜0.05). Conclusion Early APD can significantly shorten stay time in ICU and mechanical ventilation time in SAP patients, and improve levels of laboratory test indexes. 2021 Vol. 28 (35): 40-42转46 [Abstract] ( 44 ) HTML (30 KB)  PDF  (0 KB)  ( 7 ) 43 Pharmacokinetic and pharmacodynamic analysis of Moxifloxacin Hydrochloride and Sodium Chloride Injection in the treatment of lower respiratory tract infection ZHANG Chao1 XIAO Ting2▲ Objective To analyze the pharmacokinetics and pharmacodynamics of Moxifloxacin Hydrochloride and Sodium Chloride Injection in patients with lower respiratory tract infection (LRTI). Methods Seventy-six LRTI patients admitted to Jiujiang First People′s Hospital from March 2019 to March 2021 were selected as the study subjects. All patients received intravenous infusion of moxifloxacin hydrochloride and sodium chloride injection. Blood concentration of moxifloxacin (Mox) was determined by high performance liquid chromatography, and minimum inhibitory concentration (MIC) of bacteria was determined by broth dilution method. The therapeutic effect, etiological efficacy, plasma concentration of Mox and MIC of pathogenic bacteria were observed. Results The total effective rate of 76 patients was 89.47% (68/76), among which the total effective rate of 36 patients with pneumonia was up to 100.00% (36/36). Before treatment, 76 strains of pathogenic bacteria were detected in 76 patients, among which Mycoplasma pneumoniae had the highest detection rate, followed by Staphylococcus aureus. The clearance rate of pathogenic bacteria after treatment was 90.79% (69/76). After single dose, Mox peak concentration, trough concentration and steady-state plasma concentration were (4.25±0.06) mg/L, (1.44±0.08) mg/L and (3.67±0.05) mg/L, respectively. Mox showed good sensitivity to Mycoplasma pneumoniae and Streptococcus pneumoniae, with MIC of 0.25 mg/L. Mox had poor sensitivity to Staphylococcus aureus. Conclusion Moxifloxacin hydrochloride and sodium chloride injection has a better therapeutic effect in LRTI patients, which can achieve effective therapeutic concentration and remove pathogenic bacteria. 2021 Vol. 28 (35): 43-46 [Abstract] ( 44 ) HTML (31 KB)  PDF  (0 KB)  ( 5 ) 47 Application of ACT standardized monitoring process in ECMO patients with heparin anticoagulation WEI Ling Objective To explore the application value of the standardized monitoring process of activated coagulation time (ACT) in heparin anticoagulation in patients with extracorporeal membrane oxygenation (ECMO). Methods A total of 46 patients who underwent ECMO treatment in the intensive care unit of our hospital from January 2019 to December 2020 were selected，according to different treatment methods, they were divided into study group (30 cases) and control group (16 cases). The two groups of patients were given heparin during the ECMO process. The control group used the conventional ACT monitoring method, and the study group used the ACT standardized monitoring process on the basis of the control group. The service life of the membrane lung, the probability of successful withdrawal, the survival rate within 3 months, the degree of coagulation of the membrane lung, pump and pipeline, and the degree of unfavorable bleeding between the two groups of patients were compared. Results The service life of the membrane lung in the study group was longer than that in the control group, and the successful weaning rate and survival rate within 3 months were higher than those in the control group, the differences were statistically significant (P＜0.05). The degree of coagulation of the membrane lung, pump and pipeline in the study group were better than those of the control group,the differences were statistically significant (P＜0.05). The degree of bleeding in the study group was better than that of the control group, and the difference was statistically significant (P＜0.05). Conclusion The application of ACT standardized monitoring process to ECMO patients can make heparin achieve the best anticoagulation state, improve the degree of blood coagulation, reduce the occurrence of adverse bleeding, there by effectively increasing the patient′s successful withdrawal rate and survival rate within 3 months, it has a high clinical application value. 2021 Vol. 28 (35): 47-49转53 [Abstract] ( 65 ) HTML (30 KB)  PDF  (0 KB)  ( 7 ) 50 A comparative study of Indobufen and Aspirin in the treatment of acute cerebral infarction CHEN Lin1 CHEN Lan1 ZHANG Yong-Cheng1 ZENG Xian-jing2▲ Objective To compare the efficacy and safety of Indobufen and Aspirin in the treatment of acute cerebral infarction. Methods From July to October 2020, a total of 60 cases of cerebral infarction admitted to the Department of Neurology of Affiliated Hospital of Jinggangshan University were selected as the research objects, divide into the experimental group (30 cases) and the control group (30 cases) according to the random number table method. On the basis of general conventional treatment, the test group was given Indobufen tablets orally, and the control group was given Aspirin Enteric-coated Tablets. The treatment effects, laboratory indexes, neurological function and the incidence rate in safety evaluation index events of the two groups were compared. Results The total effective rate of treatment in the experimental group was higher than that in the control group, and the difference was statistically significant (P＜0.05).The platelet aggregation rates of adenosine diphosphate (ADP) and arachidonic acid (AA) in the experimental group after treatment were lower than those in the control group, the differences were statistically significant (P＜0.05). The score of neurological deficit after treatment in the experimental group was lower than that in the control group, and the difference was statistically significant (P＜0.05). The incidence of safety evaluation index events in the experimental group after treatment (53.3%) lower than the control group (73.4%), the difference was statistically significant (P＜0.05).Conclusion Compared with Aspirin, Indobufen can better improve the patient′s neurological function, the treatment effect and safety are higher, and a more satisfactory anti-platelet aggregation effect can be obtained. 2021 Vol. 28 (35): 50-53 [Abstract] ( 40 ) HTML (35 KB)  PDF  (0 KB)  ( 7 ) 54 Terlipressin combined with Pranolol for influence of blood pressure and hemodynamic indexes in patients with upper gastrointestinal bleeding in liver cirrhosis FAN Wen-jun1 WU Xia2▲ Objective To analyze the effects of Terlipressin combined with Propranolol on blood pressure and hemodynamics indexes in patients with upper gastrointestinal bleeding (UGB) in liver cirrhosis. Methods The clinical data of 112 patients with UGB with liver cirrhosis in Qianjiang Central Hospital from February 2019 to February 2021 were retrospectively analyzed. They were divided into reference group and experimental group according to different treatment methods, 56 patients in the reference group were treated with propranolol, and 56 patients in the experimental group were treated Terlipressin combined with Pranolol treatment, the clinical efficacy, blood pressure and hemodynamics between the two groups were compared. Results The total clinical effective rate (96.43%) of the test group was higher than the reference group(75.00%),and the difference was statistically significant (P＜0.05).The systolic blood pressure ([130.62±5.31]ml/min) after treatment in the test group was higher than the reference group (119.26±2.05) ml/min,diastolic blood pressure ([90.52±5.13]ml/min) was higher than the control group ([78.26±4.27]ml/min), the differences were statistically significant (P＜0.05). The portal vein (PV) blood flow ([705.26±13.62]ml/min) of the experimental group after treatment was less than the control group([846.26±18.62]ml/min),the PV blood flow velocity of the test group([13.26±1.05]cm/min) was slower than the control group ([17.62±2.11]cm/min), and the PV inner diameter ([9.13±1.62]mm) was shorter than that of the reference group ([13.82±2.17]mm), the differences were statistically significant (P＜0.05). Conclusion Terlipressin combined with Pranolol can effectively reduce the amount of bleeding in UGB patients with liver cirrhosis and maintain hemodynamic stability. 2021 Vol. 28 (35): 54-56转60 [Abstract] ( 38 ) HTML (32 KB)  PDF  (0 KB)  ( 7 ) 57 Effect analysis of intravascular interventional therapy in rupture and hemorrhage of middle cerebral artery aneurysm combined with hematoma WU Shi-zhong LIN Kun ZHENG Peng-feng LU Feng LIAO Jing-wei Objective To investigate the effect of intravascular interventional therapy in rupture and hemorrhage of middle cerebral artery aneurysm combined with hematoma. Methods Retrospective analysis of the clinical data of 33 patients with aneurysm admitted to the Fujian Provincial Hospital South Branch from June 2015 to December 2019. According to the different treatment methods, they were divided into the intervention group (18 cases) and the craniotomy group (15 cases). The interventional group received endovascular embolization, and the craniotomy group received craniotomy. The operation time, prognosis and postoperative complications of the two groups were compared. Results The operation time of the intervention group was shorter than that of the craniotomy group, the difference was statistically significant (P＜0.05). There was no significant difference in Glasgow outcome scale (GOS) score of the two groups after 12 months of follow-up (P>0.05). There was no significant difference in the incidence of hydrocephalus and cerebral infarction between the two groups (P＞0.05). The incidence of intracranial infection in the intervention group was lower than that in the craniotomy group, and the difference was statistically significant (P＜0.05). Conclusion There is no significant difference in the long-term prognosis between intravascular interventional therapy and craniotomy in the treatment of rupture and hemorrhage of middle cerebral artery aneurysm combined with hematoma. The former has shorter operation time and lower incidence of postoperative intracranial infection. Endovascular intervention is a safe and effective surgical method for such patients. 2021 Vol. 28 (35): 57-60 [Abstract] ( 42 ) HTML (30 KB)  PDF  (0 KB)  ( 6 ) 61 Application effect of Calcium Polycarbophil in the perioperative period of mixed hemorrhoid JIANG Hao-jie WANG Jian▲ XU Yong-qiang Objective To explore the application effect of Calcium Polycarbophil in the perioperative period of mixed hemorrhoid. Methods A total of 120 patients with mixed hemorrhoids in Department of Anorectal, the Second Affiliated Hospital of Xuzhou Medical University from June 2019 to June 2020 were enrolled in this study. The patients were randomized digital tables and divided into observation group and control group, a total of 60 casees in each group. The control group was given high-quality care in the anorectal department, and the observation group was taken orally with Calcium Polycarbophil Tablets on the basis of the control group. The clinical efficacy of the two groups, first defecation time, degree of defecation diffirate culty, stool trait score, postoperative complications, and adverse reactions were compared. Results The total efficacy rate of the observation group was higher than that of the control group on the 7th day after operation, and the difference was statistically significant (P＜0.05). The first defecation time after operation in the observation group was shorter than that in the control group, and the difference was statistically significant (P＜0.05).The observation group defecation difficulty on the 7th day after operation was lower than that of the control group, and the difference was statistically significant (P＜0.05). The stool trait scores of the observation group on the first and 7th day after operation were higher than those of the control group, and the differences were statistically significant (P＜0.05). There was no statistically significant difference in the pain scores of the two groups on the third day after surgery(P＞0.05). The scores of edema, effusion on the 3rd day after operation and pain, edema, and effusion on the 7th day of the observation group were lower than those of the control group, the differences were statistically significant (P＜0.05).During the entire study period, no serious adverse reactions occurred in the observation group. Conclusion Perioperative application of Calcium Polycarbophil significantly improved the postoperative defecation condition, reduced the occurrence of surgical complications, and had a good safety. 2021 Vol. 28 (35): 61-64 [Abstract] ( 52 ) HTML (39 KB)  PDF  (0 KB)  ( 8 ) 65 Analysis of endoscopic manifestations and pathological types of 277 patients with colorectal polyps FANG Xiu-luo ZHAO Tai-yun Objective To explore the endoscopic manifestations, pathological types and clinical features of colorectal polyps. Methods To retrospectively analyze the clinical data of 277 patients with colorectal polyps who underwent endoscopic treatment in the Department of Gastroenterology, the People′s Hospital of Bozhou from June 2016 to May 2019, and compare the endoscopic manifestations, pathological types and clinical features. Results A total of 277 patients with colorectal polyps were detected with a detection rate of 9.01%, including 195 males (detection rate was 11.92%) and 82 females (detection rate was 5.7%). The detection rate of colorectal polyps in the male group was higher than that of females Group, the difference was statistically significant (P＜0.05). With the increase of age, the detection rate of colorectal polyps in patients gradually increased (P＜0.05), and the detection rate of colorectal polyps in the age≥40 years patients was significantly higher than that in the age ＜40 patients, and the difference was statistically significant (P＜0.05). Morphology under endoscopy: the lesions were protruding, including 15 pedicles (3.6%), 38 pedicles(9.1%), and 364 pedicleless (87.3%). Postoperative pathological types: 76 inflammatory polyps (18.2%), 139 hyperplastic polyps (33.3%), 162 tubular adenomas (38.9%), 30 tubular villous adenomas (7.2%), villous glands 10 tumors(2.4%). A total of 202 adenomatous polyps were found in colorectal polyps, the larger the polyp, the higher the possibility of polyp cancer, the difference was statistically significant (P＜0.05). The total incidence of adenomatous polyps with a diameter＞ 1 cm was higher than the diameter adenomatous polyps ≤1 cm, the difference is statistically significant (P＜0.05). Conclusion The endoscopic manifestations of colorectal polyps are protruding, most of which are sessile.The incidence of colorectal polyps is related to age and gender. Colorectal polyps canceration is related to the size of adenomatous polyps. Clinically for men, age ≥40 years, polyps Patients with adenomatous polyps with a diameter greater than 1cm should pay close attention to early diagnosis and early treatment. 2021 Vol. 28 (35): 65-67 [Abstract] ( 47 ) HTML (31 KB)  PDF  (0 KB)  ( 5 ) 68 Effect of exercise therapy on rehabilitation of female workers with occupational musculoskeletal disorders in electronic manufacturing industry WANG Wen-zong Objective To explore the effect of exercise therapy on the rehabilitation of female workers with occupational musculoskeletal disorders in electronic manufacturing industry. Methods A total of 50 cases of female workers with occupational musculoskeletal disorders in electronic manufacturing industry admitted to the First Affiliated Hospital of Fujian Medical University from December 2019 to December 2020 were selected as the research object. They were randomly divided into observation group and control group, 25 cases in each group. The patients in the control group were treated with routine therapy, and the patients in the observation group were treated with exercise therapy. The Berg balance scale(BBS)score,timed “up and go” test(TUGT),manual muscle test(MMT)score,modified Ashworth scale(MAS) score, step size, step width, step speed, muscle activity, visual analogue scale (VAS) scores of cervical erector spinalis (CES), upper trapezius (UT) and middle trapezius (MT) were compared between the two groups. Results After intervention, the BBS score of the observation group was higher than that of the control group, and the TUGT was lower than that of the control group, the differences were statistically significant (P＜0.05). The MMT score of the observation group was higher than that of the control group, and the MAS score was lower than that of the control group, the differences were statistically significant (P＜0.05). The step size, step width and step speed of the observation group were higher than those of the control group, the differences were statistically significant (P＜0.05). The CES score, UT score and MT score of the observation group were lower than those of the control group after intervention, and the differences were statistically significant (P＜0.05). Conclusion Exercise therapy can promote the rehabilitation of female workers with occupational musculoskeletal disorders in electronic manufacturing industry. 2021 Vol. 28 (35): 68-71 [Abstract] ( 48 ) HTML (35 KB)  PDF  (0 KB)  ( 7 ) 72 Effect of intervertebral foraminal technique in the treatment of lumbar intervertebral space infection WU Bin1 WANG Fang2 DENG Xian-chao1 Objective To observe the effect of intervertebral foraminal technique in treating lumbar intervertebral space infection. Methods A total of 56 patients with lumbar intervertebral space infection admitted to Shangrao People′s Hospital from January 2017 to January 2020 were selected as the research objects, and they were divided into a control group (28 cases) and an experimental group (28 cases) according to the alternate grouping method. The control group was treated with traditional open surgery, and the experimental group was treated with foraminoscopy. The basic operation situation, length of stay, hospitalization cost, pain, infection index and total effective rate were observed in the two groups. Results The operation time and hospitalization time of patients in the experimental group were shorter than those in the control group, the amount of intraoperative blood loss in the experimental group was less than that in the control group, and the hospitalization cost in the experimental group was lower than that in the control group, with statistical significances (P＜0.05). There were no significant differences in visual analog scale (VAS) scores before and 3 d after surgery between the two groups (P＞0.05). Three days after surgery, VAS scores of the two groups were lower than those before surgery, the differences were statistically significant (P＜0.05). There were no significant differences in erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) levels between the two groups before and 3 d after surgery (P＞0.05). Three days after surgery, ESR and CRP levels in the two groups were lower than those before surgery,the differences were statistically significant (P＜0.05). There was no significant difference in the total effective rate between the two groups (P＞0.05). Conclusion The efficacy of foraminoscope technique in the treatment of lumbar intervertebral space infections is equivalent to that of open surgery, but it can significantly shorten the patients′ hospital stay, reduce medical expenses, and alleviate patients′ pain. It has the characteristics of less trauma and quicker recovery after surgery. 2021 Vol. 28 (35): 72-74转78 [Abstract] ( 38 ) HTML (33 KB)  PDF  (0 KB)  ( 7 ) 75 Effect of arthroscopic denervation of the patellofemoral joint combined with high tibial osteotomy in the treatment of knee osteoarthritis FENG Jie LIU Chun-long LIN Shi-fan DING Jian Objective To investigate the effect of arthroscopic patellofemoral denervation combined with high tibial osteotomy in the treatment of knee osteoarthritis. Methods A total of 100 patients with varus medial tibiofemoral arthritis with patellofemoral arthritis treated in the Nanchang First Hospital from January 2019 to December 2020 were selected as the research objects. According to the wishes of the patients, they were divided into arthroscopy group and total knee arthroplasty group, with 50 cases in each group. Arthroscopic radiofrequency denervation of patellofemoral joint combined with high tibial osteotomy was performed in the arthroscopic group, and total knee arthroplasty was performed in the artificial total knee arthroplasty group. The operation related conditions, hospital for special surgery(HSS)knee score,Lysholm knee score and visual analogue scale(VAS)were compared between the two groups at discharge,and the changes in hemoglobin levels before and after operation were counted. Results The intraoperative blood loss in the arthroscopic group was less than that in the total knee arthroplasty group, the difference was statistically significant(P＜0.05). The perioperative blood transfusion in the arthroscopic group was less than that in the total knee arthroplasty group, the difference was statistically significant (P＜0.05). The operation time and postoperative residence time in the arthroscopic group were shorter than those in the total knee arthroplasty group, the differences were statistically significant (P＜0.05). The HSS knee score and Lysholm knee score in arthroscopy group were higher than those in total knee arthroplasty group, the differences were statistically significant (P＜0.05). The VAS score in arthroscopy group was lower than that in total knee arthroplasty group, the difference was statistically significant (P＜0.05). The hemoglobin level in arthroscopy group was higher than that in total knee arthroplasty group, the difference was statistically significant (P ＜0.05). Conclusion For patients with knee osteoarthritis who need knee arthroplasty, radiofrequency denervation of patellofemoral joint combined with high tibial osteotomy under arthroscopy has the advantages of less trauma, rapid postoperative recovery, effective improvement of joint function and less postoperative chronic pain. 2021 Vol. 28 (35): 75-78 [Abstract] ( 44 ) HTML (33 KB)  PDF  (0 KB)  ( 7 ) 79 Effect of functional exercise combined with massage intervention on shoulder joint function in patients with frozen shoulder FU Xin-yu Objective To analyze the effect of functional exercise combined with massage intervention on shoulder joint function in patients with frozen shoulder. Methods A total of 92 cases of patients with frozen shoulder who were admitted to Fushun Hospital of Traditional Chinese Medicine from January 2019 to January 2020 were selected as the research objects, and they were divide into the control group (46 cases) and the study group (46 cases) by random number table method. The control group was took functional exercises, the research group was combined massage intervention on the basis of the control group. The pain degree, shoulder joint function and range of motion were compared between the two groups. Results After four weeks of treatment, the short form-McGill pain questionaire (SF-MPQ) score in the study group was lower than that in the control group, and the difference was statistically significant (P＜0.05). After treatment, the scores of Constant Murley shoulder function activity scale (CMS) and Japan Orthopaedics Association(JOA) shoulder disability scale in the study group were higher than those in the control group, with statistical significances (P＜0.05). After treatment, the internal rotation range, flexion range of motion, rotation range and abduction range of motion of shoulder joints in the study group were higher than those in the control group, and the differences were statistically significant (P ＜0.05). Conclusion Functional exercise combined with massage intervention can relieve shoulder pain in patients with frozen shoulder, and promote the improvement of shoulder joint function and mobility. 2021 Vol. 28 (35): 79-82 [Abstract] ( 46 ) HTML (33 KB)  PDF  (0 KB)  ( 7 ) 83 Clinical effect of posterolateral combined anteromedial approach for the treatment of complex Pilon fractures LIU Zhong-bing ZHANG De-rong Objective To evaluate the clinical effect of posterolateral combined anteromedial approach in the treatment of complex Pilon fractures. Methods A total of 48 patients with complex Pilon fracture admitted to Yancheng First People′s Hospital from April 2018 to May 2020 were selected retrospectively as the research objects. The patients were divided into posterolateral group (22 cases) and combined group (26 cases) according to different surgical approaches.The posterolateral group was treated with posterolateral approach and the combined group was treated with anterolateral and posterolateral approach. The related surgical indexes, postoperative pain degree, regression effect of swelling of affected limbs, incidence of complications were compared between the two groups. Results The average operation time and postoperative hospital stay of the combined group were longer than those of the posterolateral group, and the amount of bleeding and drainage of the combined group were more than those of the posterolateral group, and the fracture healing time of the combined group was shorter than that of posterolateral group, the differences were statistically significant (P＜0.05). The visual analogue scale (VAS) scores of the combined group were lower than those of the posterolateral group at 1, 2 and 3 weeks after operation, and the Mazur score of the combined group was higher than that of the posterolateral group after operation, the differences were statistically significant (P＜0.05). The regression effect of swelling of affected limbs of the combined group was higher than that of the posterolateral group, and the total incidence of postoperative complications of the combined group was lower than that of the posterolateral group, the differences were statistically significant (P＜0.05). Conclusion Posterolateral combined anteromedial approach is used in the surgical treatment of complex Pilon fractures, can effectively reduce the postoperative pain and swelling, improve the postoperative ankle symptoms and mobility of patients, and can effectively reduce postoperative complications, help to improve patients′ prognosis. 2021 Vol. 28 (35): 83-86 [Abstract] ( 41 ) HTML (36 KB)  PDF  (0 KB)  ( 6 ) 87 Clinical effect of different radiotherapy doses on suspicious positive lymph nodes less than 1 cm in pelvic or para-aorta of advanced cervical cancer ZHANG Ling-ling LIU Ya-wen TU Hai-yan LI Ling▲ Objective To investigate the clinical effect of different radiotherapy doses on suspicious positive lymph nodes less than 1 cm in pelvic or para-aorta of advanced cervical cancer. Methods A total of 130 patients with advanced cervical cancer who were admitted to Jiangxi Maternal and Child Health Hospital from January 2017 to December 2018 with imaging showing that the maximum short diameter of pelvic and para-aorta lymph nodes were all less than 1 cm were selected as the study subjects. They were divided into Group A (65 cases) and Group B (65 cases) by random number table method. The prescribed dose of 55 Gy/25 f was given to the suspicious positive lymph nodes less than 1 cm, and the dose of 60 Gy/25 f was given to the suspicious positive lymph nodes less than 1 cm. Clinical effects, incidence of short-term and long-term adverse reactions and long-term efficacy were compared between the two groups. Results Total efficiency comparison between the two groups at the completion of radiotherapy and 3 months after the completion of radiotherapy, with no statistically significant difference (P＞0.05). The incidence of recent radioactive adverse reactions (grade I to Ⅱ radioactive enteritis, grade I to Ⅱ radiocystitis and grade I to Ⅱ myelosuppression) in the group B were higher than those in the group A, with statistically significant differences (P＜0.05). The incidence of long-term radioactive adverse reactions (grade I to Ⅱlate radioactive enteritis) in the group B was higher than that in the group A, with statistically significant difference (P＜0.05). Conclusion For patients with advanced cervical cancer, 55 Gy can well control the suspected positive lymph nodes of pelvic lymph nodes less than 1 cm, with less adverse reactions, and can better improve the quality of life of patients, which may be worthy of clinical reference and promotion. 2021 Vol. 28 (35): 87-90 [Abstract] ( 38 ) HTML (38 KB)  PDF  (0 KB)  ( 8 ) 91 Expression of miR-218-5p in colorectal adenoma ZHU Hai-long1 ZHU Xu-you2 Objective To detect the expression of miR-218-5p in colorectal adenoma (CRA) and analyze its clinical significance. Methods A total of 16 cases of CRA paraffin tissues and eight cases of non-adenoma (NA) paraffin tissues from Shanghai Tongji Hospital from January 2011 to December 2013 were selected as the research objects. The expression of miR-218-5p was detected by quantitative real-time PCR (qRT-PCR). The differences in the expression of miR-218-5p in subgroups of adenomas, such as different gender, age, size, location, number, pathological type, and whether it is accompanied by simultaneous colorectal cancer (sCRC) were statistically analyzed. Results There was no significant difference in the expression of miR-218-5p between the CRA and NA groups (P>0.05). Subgroup analysis found that the expression of miR-218-5p in the serrated adenoma (SA) group was lower than that in the NA group with statistical significance (P＜0.05). Further analysis showed that the expressions of miR-218-5p in different genders, ages,sizes, locations, numbers and pathological types were not statistically significant; the expression of miR-218-5p with sCRC was lower than that in CRA without sCRC with statistical significance (P＜0.05). Conclusion The expression of miR-218-5p is downregulated in SA and adenoma tissues with sCRC. 2021 Vol. 28 (35): 91-94 [Abstract] ( 43 ) HTML (32 KB)  PDF  (0 KB)  ( 7 ) 95 Pain related factors and their relationship with prognosis in patients with metastatic castration-sensitive prostate cancer KANG Xi LIU Fang ZHAO Hua YAN Hai-chen Objective To explore the relationship between pain related factors and prognosis in patients with metastatic castration-sensitive prostate cancer (mCSPC). Methods A total of 365 patients with mCSPC admitted to Pingxiang People′s Hospital from January 2014 to January 2020 were retrospectively selected as the research objects. Among these of 127 patients with cancer-related pain symptoms were included in the pain group, and another 238 patients without pain symptoms were included in the pain-free group. The general data and clinical indicators of patients in the two groups were compared to determine the pain related factors, and further logistic analysis was performed to determine the relationship between the related factors and pain. Progression-free survival (PFS) and overall survival (OS) of patients in the two groups were followed up, and the end of follow-up or patient prognosis and death were taken as the endpoint. Cox regression was used to analyze the relationship between pain symptoms and patient outcomes. Results The univariate analysis showed that Gleason grade score, serum PSA level, ALP level, lymph node involvement, bone metastasis and bone metastasis were related to the occurrence of pain in mCSPC (P＜0.05). The age, course, BMI, lesion diameter, and visceral metastasis between the two groups were not significant (P＞0.05). The results of the multivariate analysis showed that the Gleason grade score, serum PSA level, ALP level, lymph node involvement, bone metastasis, and the number of bone metastases were the risk factors for pain occurrence in mCSPC patients (P＜0.05).PFS and OS were shorter than painless groups in the pain groups, which were statistically significant (P＜0.05). Pain symptoms in mCSPC patients are an independent risk factor for disease progression and shortened overall survival time (P＜0.05). Conclusion The occurrence of bone metastasis and visceral metastasis, high histological grade Gleason score, and high level of tumor markers mostly suggest pain symptoms in patients with metastatic castration-sensitive prostate cancer, which is an independent risk factor for poor prognosis. 2021 Vol. 28 (35): 95-98 [Abstract] ( 49 ) HTML (32 KB)  PDF  (0 KB)  ( 6 ) 99 Effect of low carbohydrate diet intervention in promoting pregnancy in obese patients with polycystic ovary syndrome SUN Jin-jin SUN Lin TAO Jing Objective To explore the effect of low carbohydrate diet intervention in promoting pregnancy of obese polycystic ovary syndrome (PCOS) patients. Methods A total of 86 cases of obese PCOS patients admitted to Dalian Maternal and Child Health Care Hospital from December 2018 to December 2019 were selected as the research objects, and they were randomly divided into the study group and the control group using the random number table method, with 43 cases in each group. Both groups were given symptomatic treatment and routine nursing intervention, while the control group was given routine diet guidance, the study group was given low carbohydrate diet intervention. The changes of body mass index (BMI), body fat rate, fasting insulin (FINS), fasting blood glucose (FBG), testosterone (T), follicle stimulating hormone (FSH), luteinizing hormone (LH) and other hormone levels were recorded before and after intervention in the two groups. The patients were followed up for 1 year, and the menstrual cycle recovery rate and pregnancy success rate of the two groups within 1 year after intervention were counted. Results Before intervention, there were no significant differences in the BMI, body fat rate, FINS, FBG and hormone levels between the two groups (P＞0.05). After intervention, BMI, body fat rate, FINS, FBG, T and LH levels of the two groups were lower than those before intervention, the differences were statistically significant (P＜0.05). There were no significant differences in FSH levels between the two groups before and after intervention (P＞0.05). And the BMI, body fat rate, FINS, FBG, T and LH levels of the study group after intervention were lower than those of the control group, the differences were statistically significant(P＜0.05). There was no significant difference in FSH level between the two groups (P＞0.05). The menstrual cycle recov-ery rate and pregnancy success rate of the study group were higher than those of the control group, the differences were statistically significant (P＜0.05). Conclusion In the nursing of obese patients with PCOS, the application of low carbohydrate diet intervention can effectively reduce weight and body fat, promote the improvement of glucose metabolism and reproductive endocrine, and play a role in promoting pregnancy. 2021 Vol. 28 (35): 99-101转105 [Abstract] ( 42 ) HTML (30 KB)  PDF  (0 KB)  ( 6 ) 102 Effect of prophylactic administration timing on postoperative infection of parturients and bilirubin level of newborns LIAO Xiang-lan1 XIAO Ying2 HUANG Yang1 Objective To investigate the effect of Cefazolin administration at 0.5 h before cesarean section, skin incision and after omphalotomy on postoperative infection of parturients and bilirubin level of newborns. Methods A total of 90 parturient undergoing cesarean section in the Jingdezhen Maternal and Child Health Hospital from October 2018 to March 2021 were selected. According to random number table method, they were divided into group A (intravenous infusion of Cefazolin Sodium at 0.5 h before cesarean section), group B (intravenous infusion of Cefazolin Sodium at skin incision) and group C (intravenous infusion of Cefazolin Sodium after omphalotomy), 30 cases in each group. The intraoperative blood loss, operation time and the time of temperature returning to normal in the three groups were recorded. The levels of white blood cells (WBC), neutrophils (NE) and C-reactive protein (CRP) at 48 h after surgery,and the maximum and average values of neonatal bilirubin within 1～5 d after birth were compared among the three groups. The occurrence of postoperative infection and neonatal hyperbilirubinemia was recorded. Results There were no significant differences in intraoperative blood loss and operation time among the three groups (P＞0.05). The recovery time of body temperature in group A and group B was lower than that in group C, the difference was statistically significant (P＜0.05). The levels of WBC, NE and CRP in group A and group B were lower than those in group C, the differences were statistically significant (P＜0.05). The total incidence of postoperative infection in group A was lower than that in group B and group C, the difference was statistically significant (P＜0.05). The incidence of neonatal hyperbilirubinemia in group A was higher than that in group B and lower than that in group C, the incidence of neonatal hyperbilirubinemia in group B was lower than that in group C, the difference was statistically significant (P＜0.05). Conclusion Compared with administration immediately after omphalotomy, prophylactic administration at skin incision can better reduce the risk of postoperative infection, and it can improve level of neonatal bilirubin and decrease incidence of neonatal hyperbilirubinemia compared with administration at 0.5 h before surgery. 2021 Vol. 28 (35): 102-105 [Abstract] ( 39 ) HTML (34 KB)  PDF  (0 KB)  ( 6 ) 106 Effect of rolling method combined with epidural labor analgesia on promoting natural labor ZENG Hong Objective To explore the effect of rolling method combined with epidural labor analgesia on promoting natural labor. Methods From August 2020 to March 2021, 70 primiparas with vaginal labor in the Pingxiang Maternity and Child Health Hospital in Jiangxi Province were selected as the research subjects. They were divided into the control group and the observation group according to random number table method, with 35 cases in each group. The primiparas in the control group received epidural analgesia after the uterine orifice opening 3 cm and awaiting delivery in supine position. In the observation group, rolling combined with epidural labor analgesia was performed after the opening of the uterine orifice was 3 cm wide. The first stage of labor, uterine contraction pain, postpartum hemorrhage, maternal delivery outcome, and the condition of newborn birth were compared between the two groups. Results The first stage of labor in the observation group was shorter than that in the control group, the uterine contraction pain score in the observation group was lower than that of the control group, the amount of postpartum hemorrhage in the observation group was less than that of the control group, and the differences were statistically significant (P＜0.05). The rate of natural childbirth in the observation group was higher than that in the control group, the total incidence rate of adverse birth outcomes such as maternal lateral resection, soft birth canal injury, and postpartum massive hemorrhage in the observation group was lower than that in the control group, and the differences were statistically significant (P＜0.05). The total incidence of neonatal adverse reactions such as fetal distress, neonatal asphyxia, and neonatal infection in the observation group (5.71%) was lower than that of the control group (28.57%), the Apgar score of the newborn in the observation group was higher than that of the control group, and the differences were statistically significant (P＜0.05).Conclusion The rolling method combined with epidural labor analgesia can shorten the labor process, alleviate the pain of uterine contractions, reduce postpartum hemorrhage, increase the natural delivery rate, and improve the maternal and infant outcome. 2021 Vol. 28 (35): 106-108 [Abstract] ( 41 ) HTML (30 KB)  PDF  (0 KB)  ( 6 ) 109 Clinical effect of modified forceps surgery combined with unprotected perineal midwifery ZHAO Wen-na ZHU Cui-jun ZHANG Hong-wen Objective To explore the clinical effect of modified forceps surgery combined with unprotected perineal midwifery. Methods A total of 52 puerperas undergoing vaginal midwifery admitted to Jingdezhen Second People′s Hospital were enrolled as the research objects from April 2019 to April 2021. According to the random number table method, they were divided into control groupand observation group , with 26 cases in each group. The control group used conventional forceps midwifery, and the observation group used modified forceps surgery combined with unprotected perineal midwifery. The comprehensive conditions during delivery (the second stage of labor, intrapartum blood loss, postpartum blood loss), hospitalization time and hospital expenses, maternal and neonatal complications occurrence within 1 week after surgery between the two groups were compared. Results The second schedule of the two groups were compared, the difference was not significant (P＞0.05). The postpartum bleeding, postpartum bleeding, and hospital expenses of the observation group were less than those of the control group, with statistically significant differences (P＜0.05). The hospitalization time of the observation group was shorter than that of the control group, with statistically significant difference (P＜0.05). The total incidence of postpartum and occurrence of puerperas in the observation group was lower than that of the control group, with statistically significant difference (P＜0.05). The occurrence of neonatal were compared between the two groups, the difference was not significant (P＞0.05). Conclusion The modified forceps surgery combined with unprotected perineal midwifery can effectively protect perineum and relieve delivery pain in puerperae. It does not increase the occurrence risk of maternal and neonatal complications, and significantly shortens hospitalization time and reduce hospitalization cost. 2021 Vol. 28 (35): 109-111 [Abstract] ( 39 ) HTML (31 KB)  PDF  (0 KB)  ( 7 ) 112 Effect of Misoprostol on postpartum hemorrhage of pregnancy induced hypertension CHI Zhi-qun Objective To evaluate the efficacy and safety of Misoprostol in the treatment of pregnancy hypertension and postpartum hemorrhage. Methods A total of 60 pregnant women with hypertension during pregnancy who were treated in Ruijin People′s Hospital from August 2016 to July 2019 were selected retrospectively as the research objects. They were divided into control group and experimental group by throwing method, 30 cases in each group. The control group was treated with conventional method, and the experimental group was treated with Misoprostol. The efficacy and safety of the treatment of postpartum hemorrhage were compared between the two groups. Results The amount of postpartum bleeding in the experimental group was less than that in the control group at 2 and 24 h, and the incidence of postpartum bleeding in the experimental group was lower than that in the control group, with statistical significances (P＜0.05).The incidence of adverse reactions in the experimental group was lower than that in the control group, the difference was statistically significant (P＜0.05). The levels of systolic blood pressure and diastolic blood pressure in the experimental group were lower than those in the control group after treatment, the differences were statistically significant (P＜0.05). Conclusion The treatment with Misoprostol helps to reduce the incidence of postpartum hemorrhage, reduce the amount of postpartum hemorrhage and ensure the safety of pregnant women with gestational hypertension. 2021 Vol. 28 (35): 112-114 [Abstract] ( 38 ) HTML (28 KB)  PDF  (0 KB)  ( 6 ) 115 Clinical application effect of Caffeine Citrate in premature infants and its influence on the pulmonary function of infants LAI Ri-bin LI Xiu-hua LIU Li-mei Objective To explore the clinical application effect of Caffeine Citrate in premature infants and its influence on lung function of infants. Methods From July 2019 to December 2020, 60 patients with premature infants from the First People′s Hospital of Nankang District of Ganzhou City were selected as the research subjects. They were divided into the control group and the observation group using the random number table method, with 30 cases in each group.The control group was treated with Aminophylline, and the observation group was treated with Caffeine Citrate. The pulmonary function indexes before and after treatment, ventilator-assisted ventilation time, the incidence of severe apnea of prematurity (AOP), bronchopulmonary dysplasia (BPD) and curative effect were compared between the two groups.Results Before treatment, there were no statistically significant differences in the pulmonary function indexes between the two groups (P＞0.05). After treatment, the respiratory frequency, ventilation per minute and tidal volume of the observation group were higher than those of the control group, and the differences were statistically significant (P＜0.05).The ventilator-assisted ventilation time of children in the observation group was shorter than that of the control group,and the incidence rates of severe AOP and BPD of the observation group were lower than those of the control group,and the differences were statistically significant (P＜0.05). The total effectiveness rate of treatment for children in the observation group was 93.33%, which was higher than that of the control group accounting for 73.33%, and the difference was statistically significant (P＜0.05). Conclusion Caffeine Citrate therapy is effective in premature infants and can improve pulmonary function, it is recommended to choose in preference. 2021 Vol. 28 (35): 115-117 [Abstract] ( 38 ) HTML (30 KB)  PDF  (0 KB)  ( 7 ) 118 Effect of chain-transport process under full-time supervision on maternal and infant outcomes of critically ill pregnant women DIAO Dong-xiu1 LI Yu-yu2 Objective To explore the effect of chain transport process under full-time supervision on maternal and infant outcomes of critically ill pregnant women. Methods A total of 60 cases of critical and severe pregnant women transferred from Ganzhou Medical Emergency Center from December 2018 to December 2020 were selected as the research objects, and they were divided into control group and observation group by random number table method, with 30 cases in each group. The control group was treated with the conventional transport process, and the observation group was treated with the chain transport process under full-time supervision. The treatment effect, the total incidence of adverse maternal and infant outcomes and the satisfaction of the two groups were compared. Results The timely rate of call and the success rate of pre-hospital rescue in the observation group were higher than those in the control group,and the differences were statistically significant (P＜0.05). The incidence of maternal and infant outcomes in the observation group was significantly lower than that in the control group, the difference was statistically significant (P＜0.05).The satisfaction score of observation group was higher than that of control group, and the difference was statistically significant (P＜0.05). Conclusion Chain transfer process under full-time supervision has a clear effect on improving maternal and infant outcomes of critically ill pregnant women, which can improve the treatment effect and improve maternal and infant outcomes, and has high satisfaction and is more acceptable to pregnant women. 2021 Vol. 28 (35): 118-120 [Abstract] ( 40 ) HTML (30 KB)  PDF  (0 KB)  ( 8 ) 121 Effect of Budesonide combined with atomization inhalation of Ambroxol on cytokines and lung function in neonatal meconium aspiration pneumonia CHEN Bei-yang1 LIU Lin2 ZENG Xiao-jin1 Objective To investigate the effect of Budesonide combined with atomization inhalation of Ambroxol on cytokines and lung function in neonatal meconium aspiration pneumonia. Methods The clinical data of 60 neonates with meconium aspiration pneumonia treated in the Department of Neonatology, Ruijin Maternal and Child Health Hospital of Jiangxi Province from June 2019 to June 2020 were retrospectively analyzed. According to the difference of treatment regimen, they were divided into control group and treatment group, with 30 cases in each group. The control group was treated with routine treatment, and the treatment group was treated with Budesonide combined with atomization inhalation of Ambroxol on the basis of routine regimen. The length of hospital stay, recovery time of lung function indexes,disappearance time of pulmonary rales, cyanosis disappearance time, occurrence of adverse reactions, total effective rate of disease control, inflammatory factors and lung function indexes before and after treatment were compared between the two groups. Results The length of hospital stay, recovery time of lung function indexes, disappearance time of pulmonary rales and cyanosis in the treatment group were shorter than those in the control group, and the differences were statistically significant (P＜0.05). The total incidence of adverse reactions in the treatment group was lower than that in the control group, and the difference was statistically significant (P＜0.05). The total effective rate of disease control in the treatment group was higher than that in the control group, and the difference was statistically significant (P＜0.05).After treatment, the levels of arterial partial pressure of carbon dioxide, white blood cell count, C-reactive protein, interleukin 6 and interleukin 10 in the treatment group were lower than those in the control group, while the levels of interleukin 2 and arterial partial pressure of oxygen were higher than those in the control group, the differences were statistically significant (P＜0.05). Conclusion Budesonide combined with atomization inhalation of Ambroxol in the treatment of meconium aspiration pneumonia can reduce the adverse reactions, shorten the hospitalization time, the normalization time of pulmonary function indexes, the disappearance time of pulmonary rales and cyanosis, greatly improve the levels of inflammatory factors and pulmonary function indexes, and improve the total effective rate of disease control. 2021 Vol. 28 (35): 121-124 [Abstract] ( 39 ) HTML (33 KB)  PDF  (0 KB)  ( 6 ) 125 Influence of auricular point pressing on maternal blood pressure and psychological mood in preeclampsia YANG Min LUO Quan MIAO Li-fang Objective To investigate the influence of auricular point pressing on maternal blood pressure and psychological mood in preeclampsia. Methods A total of 125 hospitalized patients who gave birth in Jiujiang Maternal and Child Health Hospital from January 2020 to May 2021 were selected as the research subjects. They were divided into control group (62 cases) and study group (63 cases) based on maternal willingness. The control group received conventional drug decompression therapy, the study group was treated with auricular point pressing. Blood pressure, efficacy,Edinburgh postpartum depression scale and follow-up were compared between the two groups. Results After treatment,the maternal systolic blood pressure and diastolic depression in the two groups were higher than those before treatment,and the differences were statistically significant (P＜0.05). After treatment, there were no statistically significant differences in systolic and diastolic blood pressure between the two groups (P＞0.05). The total effective rate in the study group was higher than that in the control group, and the difference was statistically significant (P＜0.05). Before treatment, there was no statistically significant difference in the scores of Edinburgh postpartum depression scale between the two groups (P＜0.05). After treatment, the Edinburgh postpartum depression scale score of the two groups were lower than those before treatment, and the differences were statistically significant (P＜0.05). After treatment, the Edinburgh postpartum depression scale score of the study group was lower than that of the control group, and the difference was statistically significant (P＜0.05). The proportion of good treatment compliance in the study group was higher than that in the control group, and the difference was statistically significant (P＜0.05). The proportion of postpartum emotional anxiety in the study group was lower than that in the control group, and the difference was statistically significant (P＜0.05). The rates of normal blood pressure, negative urinary protein and normal liver and kidney function in the study group were higher than those in the control group, and the differences were statistically significant (P＜0.05). Conclusion The effect of ear point sticking on postpartum hypertension of preeclampsia is significant, which can reduce the use of postpartum antihypertensive drugs and improve the state of maternal anxiety. 2021 Vol. 28 (35): 125-128转132 [Abstract] ( 45 ) HTML (39 KB)  PDF  (0 KB)  ( 7 ) 129 Application effect of single-layer cosmetic suture in perineal incision of vaginal delivery in full-term pregnancy GAN Xin-chun1 LI Ju-zhen2 Objective To study the application effect of single-layer cosmetic suture in the perineal incision for vaginal delivery of full-term pregnancy. Methods A total of 88 full-term pregnant women who underwent vaginal delivery in Yichun People′s Hospital from January 2019 to April 2020 were selected as the research objects, and they were divided into the control group and the experimental group by random number table method, with 44 cases in each group.The control group was sutured with discontinuous suture method, and the experimental group was sutured with singlelayer cosmetic suture method. Perineal wound healing, pain score, intraoperative blood loss, healing time, postoperative scar formation, perineal tear, satisfaction and infection rate were compared between the two groups. Results The perineal wound healing of the experimental group was better than that of the control group, and the difference was statistically significant (P＜0.05). At 48 and 72 h after surgery, visual analogue scale (VAS) scores of the two groups were lower than those at 24 h after surgery, the differences were statistically significant (P＜0.05). At 72 h after surgery, VAS scores of the two groups were lower than those at 48 h after surgery, and the differences were statistically significant(P＜0.05). The VAS score of the experimental group was lower than that of the control group at 48 and 72 h after surgery, and the difference was statistically significant (P＜0.05). The amount of intraoperative bleeding in the experimental group was less than that in the control group, and the healing time was shorter than that in the control group,the differences were statistically significant (P＜0.05). The maternal keloid of experimental group was better than that of control group, and the difference was statistically significant (P＜0.05). The incidence of full-thickness tear and skin tear in the experimental group were lower than those in the control group, and the differences were statistically significant (P＜0.05). The satisfaction of pregnant women in experimental group was higher than that in control group,and the difference was statistically significant (P＜0.05). There was no significant difference in the incidence of maternal infection between the two groups (P＞0.05). Conclusion The single-layer cosmetic suture of the perineal incision in full-term pregnancy and vaginal delivery can reduce the amount of intraoperative blood loss, relieve the pain of the incision of the parturient, shorten the incision healing time, thereby speed up wound healing and reduce scar formation. 2021 Vol. 28 (35): 129-132 [Abstract] ( 42 ) HTML (35 KB)  PDF  (0 KB)  ( 6 ) 133 Effect of short course of Azithromycin on symptom remission and levels of inflammatory factors in children with mild mycoplasma pneumoniae pneumonia WU Chao-rong WANG Yi-meng GAO Qin-zai▲ Objective To investigate the effect of short course of Azithromycin on symptom remission and levels of inflammatory factors in children with mild mycoplasma pneumoniae pneumonia (MMP). Methods A total of 120 children with mild MPP in the Department of Pediatrics, Gao′an Maternal and Child Health Care Hospital from January 2018 to December 2019 were selected as the research subjects. They were divided into control group and observation group by random number table method, with 60 cases in each group. The control group was treated with long-term Azithromycin(7 days), and the observation group was treated with short-term Azithromycin (5 days). The time of symptom regression,the level of serum inflammatory factors before and after treatment and the total incidence of adverse reactions were compared between the two groups. Results There was no significant difference in the disappearance time of cough and lung rales between the two groups (P＞0.05). The levels of serum C-reactive protein (CRP) and white blood cell count(WBC) in two groups after treatment were lower than before, the differences were statistically significant (P＜0.05).There was no statistical difference in the levels of serum CRP and WBC between two groups after treatment (P＞0.05).The total incidence of adverse reactions in observation group (8.33%) was lower than that in control group (21.67%),the difference was statistically significant (P＜0.05). Conclusion The efficacy of short course of Azithromycin in the treatment of children with mild MPP is similar to that of long course of azithromycin, which can reduce the level of inflammatory factors in children with short symptom resolution time, less adverse reactions, and high safety. 2021 Vol. 28 (35): 133-135 [Abstract] ( 41 ) HTML (31 KB)  PDF  (0 KB)  ( 6 ) 136 Effect of postoperative respiratory tract management in children with congenital heart disease under cardiopulmonary bypass FENG Ya-bin Objective To investigate the effect of postoperative respiratory tract management in children with congenital heart disease under cardiopulmonary bypass. Methods Seventy-two children with congenital heart disease undergoing cardiopulmonary bypass in Changzhou Children′s Hospital affiliated to Nantong University from January 2018 to December 2020 were selected as the research subjects. According to the random number method, they were divided into control group and observation group, with 36 cases in each group. The control group received routine management and the observation group received respiratory tract management. Complications, postoperative recovery indicators (postoperative hospital stay, postoperative monitoring time, mechanical ventilation time), respiratory and circulatory system indicators (heart rate, respiratory rate, blood oxygen saturation) were compared between the two groups. Results The total incidence of complications in the observation group was 5.56%, lower than 30.56% in the control group, and the difference was statistically significant (P＜0.05). The postoperative hospital stay, postoperative monitoring time and mechanical ventilation time in the observation group were shorter than those in the control group, and the differences were statistically significant (P＜0.05). There was no significant difference in respiratory and circulatory system indexes between the two groups before intervention (P＞0.05). After intervention, the heart rate, respiratory rate in the observation group were lower than those in the control group, and blood oxygen saturation was higher than in the control group, the differences were statistically significant (P＜0.05). Conclusion Respiratory tract management after pediatric congenital heart surgery under cardiopulmonary bypass can significantly reduce complications, improve respiratory and circulatory system indexes, and have positive significance for postoperative recovery. 2021 Vol. 28 (35): 136-139 [Abstract] ( 31 ) HTML (37 KB)  PDF  (0 KB)  ( 8 ) 140 Application of Rhubarb-Mirabilite Powder combined with conventional anti-infective treatment in patients with abdominal wall incision infection or dehiscence after cesarean section DAI Xin-wei WU Hong▲ Objective To analyze the clinical effect of Rhubarb-Mirabilite Powder combined with conventional anti-infective treatment in patients with abdominal wall incision infection or dehiscence after cesarean section. Methods A total of 87 patients with abdominal wall incision infection or dehiscence after cesarean section treated in the Affiliated Suzhou Hospital of Nanjing Medical University (Suzhou Municipal Hospital) from January 1, 2018 to December 31,2020 were selected for retrospective analysis. According to their treatment methods, they were divided into the control group (43 cases) and the observation group (44 cases). The control group received anti-infection and conventional dressing change. The observation group received anti-infection and conventional dressing change treatment, and external application of Rhubarb-Mirabilite Powder was given to the incisions additionally. The incision healing grade, bacterial culture negative time, induration disappearance time, incision complete healing time, hospitalization time, inflammatory factor indexes (C-reactive protein [CRP], procalcitonin [PCT], white blood cell count [WBC]), the re-debridement and suture rate were compared between the two groups. Results The incision healing grade of the observation group was better than that of the control group, and the difference was statistically significant (P＜0.05). The bacterial culture negative time, induration disappearance time, incision complete healing time, hospitalization time in the observation group were shorter than those in the control group, and the differences were statistically significant (P＜0.05). After one week of treatment, the levels of CRP, PCT and WBC in the observation group were lower than those in the control group, and the differences were statistically significant (P＜0.05). After 2 weeks of treatment, there was no significant difference in the levels of CRP, PCT and WBC between the two groups (P＞0.05). The rate of re-debridement and suture in the observation group was lower than that in the control group, and the difference was statistically significant (P＜0.05). Conclusion The external application of Rhubarb-Mirabilite Powder combined with conventional anti-infective treatment can effectively promote the healing of infected incisions after cesarean section, reduce the rate of re-debridement and suture, and shorten the hospitalization time. 2021 Vol. 28 (35): 140-143 [Abstract] ( 39 ) HTML (37 KB)  PDF  (0 KB)  ( 7 ) 144 Application value of cow's milk-related symptom score in early identification of infant milk protein allergy in primary hospitals CHEN Dong-chang1 WANG Ying-hong2 XIAO Wen3 Objective To analyze the application value of cow′s milk-related symptom score (CoMiSS) in early identification of infant milk protein allergy (CMPA) in primary hospital. Methods Forty infants suspected of CMPA in community Health Service Center of College Campus in Rongjiang New Area of Ganzhou from January 2019 to June 2020 were selected as the research object, CoMiSS score screening was performed, in which infants with score ≥12 point were classified as screening positive group A, and infants with score ＜12 point as screening negative group B. Food avoidance and stimulation tests were used as the gold standard to analyze the accuracy, sensitivity and specificity of CoMiSS score in early identification of CMPA. Results In group A, 9 children were diagnosed as CMPA by food avoidance and stimulation tests, and the positive rate was 40.91%. One child in group B was confirmed as CMPA by food avoidance and stimulation test, and the positive rate was 5.56%, the positive rate of diagnosis was statistically significant between the two groups (P＜0.05). The accuracy, sensitivity and specificity of early identification of CMPA were 65.00%, 90.91% and 55.17%, respectively. Conclusion The feasibility of using comiss score in early identification of infant CMPA is strong, which is suitable for primary hospitals. 2021 Vol. 28 (35): 144-146转150 [Abstract] ( 41 ) HTML (31 KB)  PDF  (0 KB)  ( 7 ) 147 Correlation analysis of dry eye with myopia and gender in children CHANG Yi-li HE Hai XING Li-zhou LIU Yan LUO Wei Objective The correlation between dry eye with myopia and gender was analyzed by ocular surface analyzer.Methods A total of 87 patients (164 eyes) with emmetropia and myopia aged 7-15 years from March to July 2020 in Eye Hospital Affiliated of Nanchang University were selected as the study subjects. They were divided into emmetropia group (31 eyes), low myopic group (73 eyes) and moderate myopic group (60 eyes) according to equivalent spheroscopy(SE). All subjects were examined by ocular surface analyzer, non-invasive first break-up time (NIBUT-f) and non-invasive mean break-up time (NIBUT-v) were measured and dry eye grading was performed. The correlation between gender, degree of myopia and NIBUT-f, NIBUT-v and dry eye grade was analyzed. Results Male NIBUT-v was lower than female, and dry eye grade was higher than female, the difference was statistically significant (P＜0.05), but there was no significant difference in NIBUT-f between male and female (P＞0.05). Both NIBUT-f and NIBUT-v in emmetropia group were higher than those in myopic group, and the differences were statistically significant (P＜0.05).There were no significant differences in NIBUT-f, NIBUT-v and dry eye grading of different degrees of myopia (P＞0.05). SE had no correlation with NIBUT-f and NIBUT-v (P＞0.05). Conclusion Male children had shorter NIBUT-V and higher degree of dryness than female children. Compared with emmetropia, the nibut-F and NIbut-V of myopic children decreased, but the degree of myopia was not related. 2021 Vol. 28 (35): 147-150 [Abstract] ( 39 ) HTML (34 KB)  PDF  (0 KB)  ( 7 ) 151 Clinical application effect of corneal bandage lens after surgery of severe ptosis WANG Ting JIANG Yan-hua▲ Objective To investigate the protective effect of corneal bandage lens after surgery of severe ptosis.Methods A total of 166 patients (248 eyes) with severe ptosis were selected from the Ophthalmic Plastic Surgery Center, Shenyang Fourth People′s Hospital from December 2017 to December 2020, who were treated with combination of fascia sheath suspension and levator palpebrae shortening. They were divided into the observation group and the control group by the random number table method, with 83 patients (124 eyes) in each group. The observation group was wearing corneal bandage lens, and the control group was not wearing corneal bandage lens. After a month of follow-up, the corneal staining and postoperative pain were compared between the two groups. Results The corneal staining scores of the observation group were lower than those of the control group at 1, 7 and 20 days after surgery, and the differences were statistically significant (P＜0.05). The visual analogue scale scores in the observation group were lower than those in the control group at 1, 7 and 20 days after surgery, and the differences were statistically significant (P＜0.05). Conclusion Corneal bandage lens can significantly relieve the postoperative pain symptoms of patients with ptosis, protect the corneal epithelial defect caused by early postoperative hypophasis or lagophthalmus, avoid the occurrence of postoperative exposure keratitis, and significantly relieve the postoperative discomfort symptoms of patients with ptosis,which is worthy of clinical promotion. 2021 Vol. 28 (35): 151-153转157 [Abstract] ( 35 ) HTML (32 KB)  PDF  (0 KB)  ( 6 ) 154 Analysis of visual acuity and visual quality of patients after multifocal intraocular lens implantation HE Jing XIE Ping▲ JIANG Hui-feng OUYANG Jun Objective To explore the visual acuity and visual quality of patients after multifocal intraocular lens implantation. Methods From July 2019 to February 2021, 60 patients with cataract phacoemulsification combined with intraocular lens implantation were selected as the research objects, and they were divided into control group (30 cases) and observation group (30 cases) by digital parity method. The control group was implanted with the single-focal intraocular lens, and the observation group was implanted with a multifocal intraocular lens. The visual acuity, postoperative symptoms of poor vision, wearing glasses, visual function and quality of life were compared between the two groups. Results The distance-corrected near visual acuity(DCNVA)and uncorrected near vision acuity(UCNVA)of the observation group after distance vision correction were lower than those of the control group, and the difference was statistically significant (P＜0.05). There were no statistically significant difference in the best corrected near vision acuity (BCNVA), best corrected distance visual acuity (BCDVA), and uncorrected distance vision acuity (UCDVA) between the two groups (P＞0.05). There was no significant difference in glare and halo score of postoperative visual impairment between the two groups (P＞0.05). The rate of wearing glasses in the observation group was lower than that in the control group, and the difference was statistically significant (P＜0.05). The visual function and quality of life scores of the observation group were lower than those of the control group, and the difference was statistically significant (P＜0.05). Conclusion Multifocal intraocular lens implantation can effectively improve the vision and poor vision symptoms of cataract patients, reduce the rate of wearing glasses, and improve the visual quality of patients. It has clinical application value. 2021 Vol. 28 (35): 154-157 [Abstract] ( 40 ) HTML (37 KB)  PDF  (0 KB)  ( 7 ) 158 Clinical effect of glass fiber post and zirconia all-ceramic crown in the treatment of posterior molar tooth defect WANG Shan FANG Li Objective To investigate the clinical effect of glass fiber post and zirconia all-ceramic crowns in the treatment of molar defects. Methods A total of 79 cases of posterior molar tooth defects (168 tooth defects) admitted to the Department of Stomatology, Fuzhou First People′s Hospital from October 2019 to March 2020 were selected as the research objects. According to the repair methods selected by the patients, they were divided into a control group (39 patients, 81 teeth) and an observation group (40 patients, 87 teeth). The control group was repaired with cast post and cobalt-chromium porcelain crown, and the observation group was repaired with glass fiber post and zirconia all-ceramic crown. Both groups of patients were followed up for 6 months to compare the repair success rate, chewing function and repair effect of the two groups. Results The success rate of repair was 88.89% in the observation group and 95.40% in the control group, and there was no statistical significance between the two groups (P＞0.05). There was no significant difference between the mastication efficiency of the affected side of the observation group and the healthy side (P＞0.05),the mastication efficiency of the affected side of the observation group was higher than that of the control group, and the difference was statistically significant (P＜0.05). The marginal tightness, color matching, gum health, restoration integrity, and surface wear of the observation group were better than those of the control group, and the differences were statistically significant (P＜0.05). Conclusion The clinical effect of glass fiber post zirconia all-ceramic crown repairing the molar tooth defect after treatment is significant, with little impact on the patient′s masticatory ability, and the repair effect is good, which is worthy of clinical promotion. 2021 Vol. 28 (35): 158-160转164 [Abstract] ( 43 ) HTML (32 KB)  PDF  (0 KB)  ( 8 ) 161 Clinical effect of chair side CAD/CAM glass ceramic inlay and light curing composite resin in the treatment of wedge-shaped defect SUN Ben-qiang Objective To explore the clinical effect of chair side CAD/CAM glass ceramic inlay and light curing composite resin in the treatment of wedge-shaped defect. Methods A total of 40 patients with wedge-shaped teeth filling in Stomatology Hospital Affiliated to Xiamen Medical College from June 2017 to August 2019 were selected as the study subjects. They were divided into study group and control group by random number table method, with 20 patients in each group. The study group was repaired with CAD/CAM glass ceramic inlay beside the chair, and the control group was filled with light curing composite resin. The patients were followed up for 2 years after treatment. The treatment effect, restoration aesthetics, quality of life score and long-term effect were compared between the two groups.Results The success rate of repair in the study group was 95.00%, which was higher than 55.00% in the control group,the difference was statistically significant (P＜0.05). The color, semitaphaneity and edge aesthetic score of the study group were higher than those of the control group, the differences were statistically significant (P＜0.05). There was no significant difference in morphology between the two groups (P＞0.05). The scores of quality of life in the study group were lower than those in the control group, the differences were statistically significant (P＜0.05). The long-term effect of the study group was better than that of the control group, the difference was statistically significant (P＜0.05). Conclusion Chair side CAD / CAM glass ceramic inlay has a good effect in the repair and treatment of wedge-shaped defects, with high tooth aesthetics and good long-term effect, which is worthy of popularization. 2021 Vol. 28 (35): 161-164 [Abstract] ( 37 ) HTML (31 KB)  PDF  (0 KB)  ( 6 ) 165 Analysis of anti-inflammatory and analgesic effects of Compound Toothong Tincture on gingivitis and pericoronitis LIU Lei Objective To investigate the clinical effect of Compound Toothong Tincture on gingivitis and pericoronitis.Methods A total of 100 patients with gingivitis and pericoronitis treated in Department of Stomatology, People′s Hospital of Diaobingshan City from March 2018 to May 2019 were selected as the research subjects. They were divided into control group (n=50) and experimental group (n=50) according to calculated random number. The control group was treated with iodine glycerin, and the experimental group was treated with compound toothpain tincture. The pain scores after 2 weeks of treatment and the pain relief and inflammation subside before and after treatment of the two groups were compared. Results After 2 weeks of treatment, the proportion of patients with pain score ＜3 in the experimental group was lower than that in the control group, the difference was statistically significant (P＜0.05). The pain relief scores of the experimental group were lower than those of the control group at 3 and 7 days after treatment, with statistical significance (P＜0.05). The gingivitis index of the experimental group was lower than that of the control group at 3 and 7 days after treatment, the difference was statistically significant (P＜0.05). Conclusion The treatment of gingivitis and pericoronitis with Compound Toothong Tincture is effective in relieving pain and improving the quality of life of patients. 2021 Vol. 28 (35): 165-167 [Abstract] ( 31 ) HTML (32 KB)  PDF  (0 KB)  ( 7 ) 168 Application of Dexmedetomidine in patients with nausea and vomiting after endoscopic gynecological surgery GU You-lan CHEN Yan Objective To investigate the application of Dexmedetomidine in patients with nausea and vomiting after endoscopic gynecological surgery. Methods From January 2019 to January 2021, a total of 66 patients underwent laparoscopic gynecological surgery at Guangzhou Panyu District He Xian Memorial Hospital and who developed nausea and vomiting after the operation were selected as the research objects, and they were divided into the study groups and the control group according to the drawing lots method, with 33 cases in each. The control group used Sufentanil 150 μg,and the study group used Sufentanil 150 μg + Dexmedetomidine 200 μg. And set the lock time, infusion rate and single load dose to 15 min, 2 ml/h, 2 ml in sequence. The intraoperative Opioid dosage, pneumoperitoneum pressure and time,and total gas consumption were compared between the two groups of patients. At the same time, the nausea and vomiting, sedation scores of the two groups of patients at different time periods were observed. Results There were no statistically significant differences of intraoperative Opioid dosage, pneumoperitoneum pressure and time, and total gas consumption between the two groups (P＞0.05). At six to below twelve hours, twelve to below eighteen hours, eighteen to below twenty-four hours after surgery,the nausea and vomiting score of the study groups were higher than those of the control group,and the differences were statistically significant (P＜0.05).At below six hours,six to below twelve hours,twelve to below eighteen hours, eighteen to below twenty-four hours after surgery, the sedation score of the study groups were lower than those of the control group, and the differences were statistically significant (P＜0.05). Conclusion The improperness mirror and gynecologic surgery in patients with postoperative nausea and vomiting condition, application of self-control vein analgesia pump, scientific administration of Dexmetomidine drugs is better than the simple application of Sulfentanyl, could keep calm and able to help patients, and the effect is remarkable, it is worth promoting. 2021 Vol. 28 (35): 168-171 [Abstract] ( 48 ) HTML (33 KB)  PDF  (0 KB)  ( 6 ) 172 The application effect of Dexmedetomidine combined with spinal epidural anesthesia in patients with femoral intertrochanteric fractures LIU Li QIU Han Objective To explore the effect of Dexmedetomidine combined with spinal epidural anesthesia in patients with femoral intertrochanteric fractures. Methods A total of 106 patients with intertrochanteric fractures of the femur admitted to Jurong City Hospital of Traditional Chinese Medicine from January 2019 to December 2020 were selected as the research objects. They were divided into the control group (53 cases) and the observation group (53 cases) according to the random number table method. Both groups were given spinal epidural anesthesia. In the control group,normal saline was pumped within 15 minutes after successful anesthesia and continued to 30 minutes before the end of the operation. The observation group was given Dexmedetomidine in the same way. The hemodynamics, stress response indicators, cognitive function, and adverse reactions occur of the two groups were compared. Results At 5 minutes before anesthesia (T0), there were no statistically significant differences of heart rate (HR), meverage arterial pressure(MAP) between the two groups (P>0.05). At 10 minutes after anesthesia (T1), the end of the operation (T2), postoperative 1 hours (T3), the HR and MAP of the observation group were lower than that of the control group at the same period,with statistically significant differences (P＜0.05). At T1, T2, T3, the HR and MAP of the control group were higher than that at T0 in the group, with statistically significant differences (P＜0.05). At T2, the HR and MAP of the observation group were higher than that at T0 in the group, with statistically significant differences (P＜0.05). At T0, there were no statistically significant differences of cortisol (Cor), blood glucose (GLU) between the two groups (P>0.05). At T1, T2, T3,the Cor and GLU of the observation group were lower than that of the control group at the same period, with statistically significant differences (P＜0.05). At T1, T2, T3, the Cor and GLU of the control group were lower than that of at T0 in the group, with statistically significant differences (P＜0.05). At T2, the Cor of the observation group was higher than that at T0 in the group, with statistically significant difference (P＜0.05). At T1, T2, the GLU of the observation group was higher than that at T0 in the group, with statistically significant difference (P＜0.05). At T0, there was no statistically significant difference of mini-mental state examination(MMSE)score between the two groups(P>0.05).On 1,3,7 days after surgery,the MMSE score of the two groups were lower than those before surgery in the group, with statistically significant differences (P＜0.05). On 1, 3, 7 days after surgery, the MMSE score of the observation group were higher than those of the control group on the same period, with statistically significant differences (P＜0.05). There was no statistically significant difference of total incidence of adverse reactions between the two groups (P>0.05). Conclusion Dexmedetomidine combined with spinal epidural anesthesia is effective in patients with intertrochanteric fractures. It can ensure stable hemodynamics, control stress response, less cognitive impairment, and no serious adverse reactions. It is safe feasible. 2021 Vol. 28 (35): 172-175 [Abstract] ( 42 ) HTML (41 KB)  PDF  (0 KB)  ( 6 ) 176 Clinical effect of Bifidobacterium Quadruple Viable Tablets combined with Buzhong Yiqi Decoction in the treatment of weak spleen and stomach type senile chronic diarrhea ZHONG Hua-wen LUO Li-yuan HUANG Xiao-jing ZHANG Si-rong ZHUANG Dong-ming FAN Lian-na Objective To explore the clinical effect of Bifidobacterium Quadruple Viable Tablets combined with Buzhong Yiqi Decoction in the treatment of weak spleen and stomach type senile chronic diarrhea. Methods A total of 120 patients with weak spleen and stomach type senile chronic diarrhea admitted to Yangjiang Hospital of Traditional Chinese Medicine from January 2019 to January 2021 were selected as the research subjects, and they were divided into conventional group and combined group by coin flipping method, with 60 cases in each group. Patients in the conventional group were treated with Bifidobacterium Quadruple Viable Tablets, while patients in the combined group were treated with Buzhong Yiqi Decoction on the basis of the conventional group. The efficacy, symptom improvement, diarrhea relief time and the incidence of adverse reactions were compared between the two groups. Results There was no significant difference in the total effective rate between the two groups (P＞0.05). Symptom scores after treatment in the two groups were lower than those before treatment, and symptom score after treatment in combined group was lower than that in the conventional group, the differences were statistically significant (P＜0.05). The diarrhea relief time in combined group was shorter than that in conventional group, and the difference was statistically significant (P＜0.05). There was no significant difference in the total incidence of adverse reactions between the two groups (P＞0.05). Conclusion The therapeutic effect of Bifidobacterium Quadruple Viable Tablets combined with Buzhong Yiqi Decoction in treating of weak spleen and stomach type senile chronic diarrhea is basically equivalent to that of Bifidobacterium Quadruple Viable Tablets alone, but the symptoms of patients with combine Buzhong Yiqi Decoction are more improved, and the relief time of diarrhea is shorter. 2021 Vol. 28 (35): 176-178 [Abstract] ( 92 ) HTML (31 KB)  PDF  (0 KB)  ( 7 ) 179 Clinical effect of Modified Xuanfu Daizhe Decoction combined with Western medicine in the treatment of hiccups after stroke YU Li-wen Objective To explore the clinical effect of Modified Xuanfu Daizhe Decoction combined with Western medicine in the treatment of hiccups after stroke. Methods A total of 100 patients with hiccup after stroke in the Department of Neurology of Shenyang Orthopaedic Hospital, Chengji Hospital from December 2018 to June 2019 were selected as the research objects. They were divided into Chlorpromazine group and combined treatment group by random number table method, 50 cases in each group. Chlorpromazine group received routine clinical treatment, Chlorpromazine Hydrochloride 25 mg/time, twice a day, orally. Patients in the combined treatment group were given Modified Xuanfu Daizhe Decoction on the basis of Chlorpromazine group. The treatment period for both groups was 21 days. The scores of hemiplegia, slurred speech, crooked mouth, constant hiccups in the throat, general weakness and dull pain in the gastric cavity were compared between two groups before and after treatment. The Wang′s scale score and hiccup efficacy score were compared between two groups before and after treatment. The blood Ca2+ and Na+ levels of the two groups of patients before and after treatment were compared. The total effective rate was compared between the two groups. Results The scores of hemiplegia, slurred speech, crooked mouth, constant hiccups in the throat, general weakness and dull pain in the gastric cavity of the two groups after treatment were lower than those before treatment, and the differences were statistically significant (P＜0.05). The scores of hemiplegia, slurred speech, crooked mouth, constant hiccups in the throat, general weakness and dull pain in the gastric cavity of patients in the combined treatment group were lower than those in the Chlorpromazine group after treatment, and the differences were statistically significant (P＜0.05). The hiccup efficacy scores of the two groups after treatment were lower than those before treatment, and the differences were statistically significant (P＜0.05). The hiccup efficacy score of patients in the combined treatment group after treatment was lower than that in the Chlorpromazine group, and the difference was statistically significant (P＜0.05). The Wang′s scale scores of the two groups after treatment were higher than those before treatment, and the differences were statistically significant (P＜0.05). The Wang′s scale score after treatment in the combined treatment group was higher than that in the Chlorpromazine group, the difference was statistically significant (P＜0.05). The serum Ca2+and Na+ levels of the two groups after treatment were higher than those before treatment, and the differences were statistically significant (P＜0.05). The blood Ca2+and Na+levels of the patients in the combined treatment group were higher than those in the Chlorpromazine group after treatment, and the differences were statistically significant (P＜0.05).The total effective rate of clinical treatment of patients in the combined treatment group was 94.00%, which was higher than 66.00% in the Chlorpromazine group, and the difference was statistically significant (P＜0.05). Conclusion The application of Modified Xuanfu Daizhe Decoction on the basis of Western medicine treatment can have a better therapeutic effect on hiccups after stroke. It can effectively improve patients with hemiplegia, hiccups and other symptoms, and balance blood Ca2+and blood Na+levels in the body. 2021 Vol. 28 (35): 179-183 [Abstract] ( 38 ) HTML (45 KB)  PDF  (0 KB)  ( 5 ) 184 Study on the value of serum pepsinogen combined with tumor markers CEA, CA199, CA125 in the diagnosis of gastric cancer LIN Rong-jun CHEN Zhen-fen YANG Li-ping CHEN Dong-ling LI Yang-yang Objective To explore the value of serum pepsinogen (PG)Ⅰ, PGⅠ/Ⅱ combined with tumor markers carcinoembryonic antigen (CEA), carbohydrate antigen 199 (CA199) and cancer antigen 125 (CA125) in the diagnosis of gastric cancer. Methods Eighty patients with gastric cancer diagnosed by pathological biopsy from People′s Hospital of Yangjiang City from January 2019 to December 2020 were selected as the gastric cancer group, 80 patients with benign gastric lesions diagnosed at the same time were selected as the benign lesion group, and 60 healthy experiencers were selected as the control group. The levels of PGⅠ, PGⅠ/Ⅱ, CEA, CEA, CA199, CA125 and the sensitivity, specificity and accuracy of single detection and combined detection were compared among the three groups. Results The PGⅠand PGⅠ/Ⅱ in the gastric cancer group were lower than those of the benign lesion group and the control group, and the differences were statistically significant (P＜0.05). The levels of CEA, CA199, and CA125 in the gastric cancer group were higher than those of the benign lesion group and the control group, and the differences were statistically significant (P＜0.05). In gastric cancer group, the sensitivity and accuracy of combined detection were higher than those of single detection, and the differences were statistically significant (P＜0.05). The specificity decreased but remained good.Conclusion The combine detection of PGⅠ, PGⅠ/Ⅱ, CEA, CA199, and CA125 has high sensitivity, accuracy and good specificity, which can improve the diagnostic efficiency of gastric cancer. 2021 Vol. 28 (35): 184-186 [Abstract] ( 53 ) HTML (31 KB)  PDF  (0 KB)  ( 8 ) 187 Distribution difference and drug resistance analysis of hospital infection of Klebsiella pneumoniae and Escherichia coli ZHENG Gang-sen1 JIANG Su-xiang2 LU Xiao-hui1 LIAN Ming-jian1▲ Objective To compare and analyze the differences between clinical isolates of Escherichia coli and Klebsiella pneumoniae, including sensitivity, specimen type separation and department distribution, so as to fully understand the drug resistance of the two main pathogens. Methods BioMerieux VITEK2 Compact automatic bacterial identification and drug sensitivity analysis system were used for bacterial identification and drug sensitivity test, and Excel software was used for data analysis. Results In 2020, 1614 strains of Escherichia coli and 579 strains of Klebsiella pneumoniae were clinically isolated, and more than half of them were isolated from urine, but there was no significant difference among different samples of Klebsiella pneumoniae. The number of Klebsiella pneumoniae isolated from respiratory tract samples was much more than that of Escherichia coli. There was no statistically significant difference between the two isolates in intensive care unit (ICU), but there was statistically significant difference in other departments. There was statistically significant difference in the detection rate of ESBLs (-) strain between the two strains (P＜0.05), but there was no statistically significant difference in the detection rate of ESBLs (-) strain (P＞0.5).The susceptibility rate of Escherichia coli to imipenem was 98.9%, while that of Klebsiella pneumoniae was 82.4%,especially in ICU, the susceptibility rate was as low as 59.5%. The susceptibility rate of Klebsiella pneumoniae isolated from sputum to imipenem was 64.8%. Four out of 102 strains of Imipenam -resistant Klebsiella pneumoniae were susceptible to tronem, while 10 out of 17 strains of imipenam-resistant Escherichia coli were susceptible to tronem. Conclusion Both Escherichia coli and Klebsiella pneumoniae are resistant to carbapenems, especially Klebsiella pneumoniae, and their carbapenemase producing types are different. Klebsiella pneumoniae is less sensitive to most antibiotics than Escherichia coli, except levofloxacin. The drug resistance problem is particularly serious in ICU, and the sensitivity of isolates isolated from whole blood is good,but that from sputum is poor. 2021 Vol. 28 (35): 187-191 [Abstract] ( 44 ) HTML (37 KB)  PDF  (0 KB)  ( 6 ) 192 Analysis of cellular immune level and serum carbohydrate antigen 153 changes in patients with breast cancer under different pathological features LI Shu-min ZHANG Ye-xia Objective To explore the changes of cellular immunity and serum carbohydrate antigen 153 (CA153) levels in breast cancer patients under different pathological characteristics. Methods A total of 104 patients with breast cancer admitted to Heze Municipal Hospital from January 2019 to May 2020 were retrospectively selected as the study subjects and set as the breast cancer group, seventy patients of benign breast disease admitted to Heze Municipal Hospital at the same period were selected as benign groups, and seventy patients with physical examination in Heze Municipal Hospital in the same period were selected as the healthy control group. The immune indicators (CD4, CD8,CD4/CD8, NK) and CA153 levels of the three groups were compared, and observed the relationship between different pathological characteristics and immune indicators and CA153. Results The levels of CD4, CD4/CD8, and NK in the breast cancer group were lower than those in the benign group and the healthy control group, and the differences were statistically significant (P＜0.05). The levels of CD8 and CA153 in the breast cancer group were higher than those in the benign group and the healthy control group, and the differences were statistically significant (P＜0.05). The levels of CD4, CD4/CD8, and NK in the benign group were lower than those in the healthy control group, and the differences were statistically significant (P＜0.05). The levels of CD8 and CA153 in the benign group were higher than those in healthy control group, and the differences were statistically significant (P＜0.05). The CD4, CD4/CD8 and NK levels were compared between the patients with different age, with or without lymph node metastasis, the differences were statistically significant (P＜0.05). The CD4, CD8, CD4, CD4/CD8, NK, and CA153 levels were compared between the patients with different pathological types, TNM stage, tumor diameter, PR, ER, and HER-2 expression, and the differences were statistically significant (P＜0.05). Conclusion The cellular immunity level and CA153 level of breast cancer patients are related to clinicopathological type, TNM stage, tumor diameter size, ER, PR, HER-2 expression, and can be used as effective indicators to distinguish breast cancer from benign breast diseases and healthy people. 2021 Vol. 28 (35): 192-195 [Abstract] ( 57 ) HTML (30 KB)  PDF  (0 KB)  ( 7 ) 196 Role of the training of scientific research ability in teaching medical professional postgraduates in the teaching hospitals HUANG Xiao-yan SUN Jing-ying XU Cui-xiang▲ Medical education is an important cornerstone of the development of health care. Since the 18th National Congress of the Communist Party of China, the medical education in China has developed vigorously, and a large number of high-quality medical talents have been cultivated to the health industry. At present, the training of medical and pharmaceutical graduate students requires both clinical research to meet the needs of clinical and scientific research.However, most teaching hospitals only focus on the cultivation of clinical professional knowledge but ignore the cultivation of scientific research ability for medical professional postgraduates, especially the cultivation and promotion of basic scientific research ability. This article aims to expose the problems existing in the cultivation of scientific research ability of medical graduate students in teaching hospitals, and further propose solutions. 2021 Vol. 28 (35): 196-198 [Abstract] ( 35 ) HTML (31 KB)  PDF  (0 KB)  ( 6 ) 199 Study on video coaching combined with double scoring system to improve the laparoscopic surgery for the standardized residents training LIANG Geng-qi GUAN Li-xian ZHAO Zhen-hua LIAO Jun-fa XU-Xun Objective To evaluate the effect of video coaching (VC) system on laparoscopic operation combined with double scoring system. Methods From January 2017 to January 2020, 24 prescription-trained physicians in the People′s Hospital of Nanhai District, Foshan City were selected as the research subjects, and were divided into experimental group (12 cases) and control group (12 cases) by random number table method. Video teaching system was used in the experimental group and traditional teaching was used in the control group. The two groups were trained in laparoscopic surgery for one year. The scores of global operation assessment of laparoscopic skills (GOALS) and objective structured assessment of technical skills (OSATS) were compared between the two groups before and after the training. Results There were no statistically significant difference in the GOALS scores and OSATS scores between the two groups before training (P＞0.05). The GOALS and OSATS scores of the two groups after training were higher than those before training, and the GOALS and OSATS scores of the experimental group after training were higher than those of the control group, the difference was statistically significant (P＜0.05). Conclusion Video coaching combined with double scoring system can make standardized training easier for residents to learn and master laparoscopic surgery operation, improve their technology and skills, and be more objective, convenient and effective compared with traditional teaching. 2021 Vol. 28 (35): 199-202 [Abstract] ( 42 ) HTML (32 KB)  PDF  (0 KB)  ( 6 ) 203 Application of Orem self-care theory combined with evidence-based nursing in patients with chronic heart failure and its effect on patients'quality of life FANG Xiao-yun CHEN Yan-mei YU Ling▲ Objective To explore the application of Orem self-care theory combined with evidence-based nursing in patients with chronic heart failure (CHF) and its effect on the quality of life of patients. Methods From June 2020 to June 2021, 90 cases of CHF patients treated in the First Affiliated Hospital of Nanchang University were selected as the research objects, they were divided into the control group (45 cases) and the study group (45 cases) according to random number table method. The control group was used conventional nursing intervention method, the study group was used Orem self-care theory combined evidence-based nursing intervention method. The quality of life, self-care ability and nursing satisfaction of the two groups were compared. Results After intervention, the scores of quality of life and self-care ability of the study group were higher than those of the control group, and the differences were statistically significant (P＜0.05). After intervention, the nursing total satisfaction of the study group was higher than that of the control group, and the difference was statistically significant (P＜0.05). Conclusion The application of Orem self-care theory combined with evidence-based nursing in patients with CHF has a significant effect. It can not only effectively improve patients′self-care ability, promote their rehabilitation, but also help to further improve the quality of life, and significantly improve their nursing satisfaction, which is worthy of clinical promotion. 2021 Vol. 28 (35): 203-206 [Abstract] ( 33 ) HTML (33 KB)  PDF  (0 KB)  ( 6 ) 207 Application of Zhushui Powder applied at six acupoints on refractory edema in patients with chronic heart failure LYU Li-fen1 FAN Huan-zhen2 KANG Feng-guang2 XIAO Nan-hai3▲ Objective To observe the effect of Zhushui Powder applied at six acupoints on refractory edema in patients with chronic heart failure (CHF). Methods From January 2020 to March 2021, 70 patients diagnosed as refractory edema of CHF in Shunde Hospital of Guangzhou University of Traditional Chinese Medicine were selected as the research objects. They were divided into the observation group (35 cases) and the control group (35 cases) according to randon number table method. Both groups were given routine drug treatment and routine nursing. On this basis, the observation group was given Zhushui Powder applied at six acupoints, the control group was given placebo applied at six acupoints,once a day, 6 hours each time, 5 days as a course of treatment, intervention for 2 courses. The changes of urine volume,weight, dyspnea and swelling of limbs were observed in the two groups. On the 10th day of intervention, the concentration of B-type natriuretic peptide (BPN) in venous blood, NYHA classification and self-care ability of the two groups were observed. The incidence of pressure ulcer, mortality and length of hospital stay of the two groups were observed. Results After the intervention, the urine volume and weight loss of the observation group were higher than those of the control group, and the scores of dyspnea and limb swelling of the observation group were lower than those of the control group, the differences were statistically significant (P＜0.05). On the 10th day of treatment, the BNP concentration in the observation group was lower than that in the control group, Barthel evaluation was higher than that in the control group, NYHA grade Ⅰ/Ⅱ in the observation group was 45.71%, while that in the control group was 15.15%, the differences were statistically significant(P＜0.05). Both groups of the mortality of in-hospital were 0, the difference was not statistically significant (P＞0.05).The incidence of pressure ulcer was 0 in the observation group and 12.12% in the control group, the difference was statistically significant (P＜0.05). The time of hospitalization in the observation group was (9.25±2.12) d, which was shorter than that of control group of (11.85±5.23) d, the difference was statistically significant (P＜0.05). Conclusion Zhushui Powder applied at six acupoints has obvious diuretic effect on refractory edema in patients with CHF. It can effectively increase the urine volume of patients, reduce weight and limb swelling, relieve the clinical symptoms caused by organ congestion, delay the deterioration of heart function, reduce the occurrence of pressure ulcers, and improve the selfcare ability and quality of life of patients, which is worthy of clinical promotion. 2021 Vol. 28 (35): 207-212 [Abstract] ( 41 ) HTML (49 KB)  PDF  (0 KB)  ( 7 ) 213 Study on the effect of comprehensive nursing combined with traditional Chinese medicine package and traditional Chinese medicine foot fumigation on postpartum rehabilitation of puerpera LIU Li-juan YANG Li-sha ZENG Shu-hua Objective To observe the effect of comprehensive nursing combined with traditional Chinese medicine package and traditional Chinese medicine foot fumigation on postpartum rehabilitation of puerpera. Methods A total of 70 cases of parturients admitted to Ruijin Maternity and Child Health Hospital from August 2020 to February 2021 were selected as the research objects, and they were divided into observation group (n=35) and control group (n=35)according to the random number table method. The control group adopts conventional nursing, and the observation group adopts comprehensive nursing with traditional Chinese medicine package and traditional Chinese medicine foot fumigation. The Hamilton anxiety scale (HAMA) score and Hamilton depression scale (HAMD) score, postpartum hemorrhage rate, hospitalization time, physical and mental recovery, lactation volume, quality of life, nursing total satisfaction were compared between the two groups. Results After nursing, the HAMA score and HAMD score in the observation group were lower than those in the control group, the differences were statistically significant (P＜0.05). The rate of postpartum hemorrhage in the observation group was lower than that in the control group, the difference was statistically significant (P＜0.05). The time of physical and mental recovery in the observation group were shorter than those in the control group, the differences were statistically significant (P＜0.05). The lactation volume of the observation group was higher than that of the control group, the difference was statistically significant (P＜0.05). There was no statistically significant difference in the quality of life scores between the two groups (P ＞0.05). The nursing total satisfaction of the observation group was higher than that of the control group, the difference was statistically significant(P＜0.05). The hospitalization time of the patients in the observation group was shorter than that in the control group, the difference was statistically significant (P＜0.05). Conclusion The use of comprehensive care combined with traditional Chinese medicine package and traditional Chinese medicine foot fumigation methods can effectively promote the postpartum recovery of the parturient, improve the nursing total satisfaction of the parturient, and effectively improve the comfort of the parturient postpartum recovery, which has good clinical application value. 2021 Vol. 28 (35): 213-216 [Abstract] ( 32 ) HTML (37 KB)  PDF  (0 KB)  ( 6 ) 217 Effect of continuous quality improvement nursing mode on blood donor reaction and blood scrap rate in blood collection PENG Fang1 SHUANG Li-hua2 YOU Gui-mei3 FU Ping-ping3 HE Jun1 Objective To explore the effect of continuous quality improvement nursing mode on the reaction of blood donors and blood scrap rate in blood collection. Methods A total of 200 blood donors who participated voluntary blood donation in Fuzhou Central Blood Station from October 2019 to October 2020 were selected as research objects, and were divided into two groups according to the random number table method, 100 cases in each group. The control group received routine nursing, while the experimental group adopted the mode of continuous quality improvement on the basis of routine nursing. The nursing satisfaction, adverse reactions and blood scrap rate of blood donors in the two groups were compared and analyzed. Results After intervention, the total satisfaction of the experimental group was 97.00%,higher than that of the control group (79.00%), the difference was statistically significant (P＜0.05). The total incidence of adverse reactions in the experimental group was 2.00%, lower than 12.00% in the control group, and the difference was statistically significant (P＜0.05). The blood scrap rate in the experimental group was 2.00%, lower than 14.00% in the control group, and the difference was statistically significant (P＜0.05). Conclusion Continuous quality improvement nursing can effectively improve the satisfaction of blood donors in blood collection stations, reduce the adverse reactions of blood donors, and reduce the blood scrap rate. 2021 Vol. 28 (35): 217-219 [Abstract] ( 44 ) HTML (31 KB)  PDF  (0 KB)  ( 7 ) 220 Early out of bed mobility intervention after surgery in elderly hip fracture patients based on the hospital elder life program protocol HU Yan-hua Objective To explore the effect of early postoperative ambulation intervention in elderly hip fracture patients based on the hospital elder life program (HELP) protocol. Methods A total of 158 cases elderly hip fracture surgery patients admitted to the Second Affiliated Hospital of the University of southern China from 2018 to d 2020 were selected as study subjects and divided into two groups according to the method of postoperative nursing intervention, the conventional group (n=82) received routine rehabilitation nursing intervention, and the HFLP group (n=76) received early out of bed activity intervention based on the help protocol, the effect after intervention between the two groups was compared. Results The time to first postoperative out of bed and hospital stay in the HELP group were shorter than those in the conventional group, with significant differences (P＜0.05). The total incidence of postoperative complications in the HELP group was lower than that in the conventional group, and the difference was statistically significant (P＜0.05). The scores of the hips and the daily living ability scores of the two groups at two weeks after surgery were higher than those of the preoperative, and the scores of the hips and the daily living ability scores of the HELP group at two weeks after surgery were higher than those of the conventional group, with significant differences (P＜0.05).Conclusion The early out of bed activity intervention based on help scheme can promote the functional recovery of elderly patients with hip fracture, promote their early out of bed activity, shorten their hospitalization time, effectively reduce the occurrence of postoperative complications, and improve their ability of daily living. 2021 Vol. 28 (35): 220-222转226 [Abstract] ( 31 ) HTML (32 KB)  PDF  (0 KB)  ( 7 ) 223 Effect of step rehabilitation mode on lumbar function and postoperative pain in patients with lumbar disc herniation PAN Ye-qing Objective To study the effect of step rehabilitation mode on lumbar function and postoperative pain in patients with lumbar disc herniation (LDH). Methods A total of 100 LDH patients who were admitted to Guangzhou Integrated Chinese and Western Medicine Hospital from February 2019 to February 2021 were selected and divided into two groups according to the random number table method, 50 cases in each group. The control group was guided by routine nursing, and the observation group carried out step rehabilitation mode intervention, the satisfaction of nursing care, postoperative complications and lumbar function and pain degree in different intervention stages of the two groups were compared. Results The score of Japanese Orthopaedic Association assessment form (JOA) in observation group was higher than that of the control group at the 4 and 12th week after operation, and the score of Oswestry dysfunction index and visual analogue score (VAS) were lower than those of the control group, the differences were statistically significant (P＜0.05). The total satisfaction of the patients in the observation group was higher than that of the control group, the difference was statistically significant (P ＜0.05). The total proportion of the patients with postoperative complications such as nerve root edema and interstitial infection in the observation group was lower than that of the control group, the difference was statistically significant (P＜0.05). Conclusion The step rehabilitation mode can obviously reduce postoperative pain, reduce complications and promote the recovery of lumbar function of LDH patients, and also obtain more satisfactory nursing evaluation. 2021 Vol. 28 (35): 223-226 [Abstract] ( 44 ) HTML (34 KB)  PDF  (0 KB)  ( 7 ) 227 Effectiveness of PDCA cycle nursing on stigma and quality of life in patients with stroke with dysphagia JI Yu-hang1 CHANG Zong-wen2▲ Objective To explore the effectiveness of Plan-Do-Check-Action (PDCA) nursing in patients with stroke with dysphagia. Methods A total of 126 patients with stroke with dysphagia treated in Dalian Fifth People′s Hospital from March 2019 to October 2020 were selected. They were divided into the observation group and the control group by random number table method, 63 cases in each group. The control group was implied daily recovery training model and the observation group was implied PDCA nursing recovery training model. After six weeks, swallowing function, stigma and quality of life were compared between two groups. Results Before the intervention, the situation of swallowing function, stima and quality of life of the observation were no statistically significant between observation group and control group (P＞0.05). After intervention, scores of swallowing function, stigma of observation were lower than those of the control group, score of quality of life in observation were higher than that of the control group, the differences were statistically significant (P＜0.05). Conclusion PDCA cycle nursing had a positive influence on improving condition, enhancing their quality of life and had certain value in the application of clinic. 2021 Vol. 28 (35): 227-230 [Abstract] ( 44 ) HTML (37 KB)  PDF  (0 KB)  ( 7 ) 231 Observation on the effect and complication rate of comfort nursing in patients undergoing appendicitis surgery WANG Yang SHE Kun-hao ZHAO Zi-ming HU Hai-yang JIN Peng MA Dan▲ Objective To explore the effect of comfort nursing in patients with appendicitis. Methods A total of 66 patients who underwent appendicitis surgery in Hongqi Hospital Affiliated to Mudanjiang Medical University from September 2017 to September 2019 were selected as the research objects. According to the dynamic random grouping method,they were divided into the control group (33 cases) and the observation group (33 cases). The control group used routine nursing intervention method and the observation group used comfort nursing intervention method. The improvement of symptoms and complications were compared between the two groups. Results Before nursing, there was no significant difference in SCL-90 scores between the two groups (P＞0.05). After nursing, the symptom checklist 90 (SCL-90) scores of the observation group were lower than those in the control group, and the SCL-90 scores of the two groups were lower than those before nursing, the differences were statistically significant (P＜0.05). The total incidence of complications in the observation group was lower than that in the control group, the difference was statistically significant (P＜0.05).Conclusion The effect of comfort nursing in patients with appendicitis surgery is significant. It can not only improve the psychological state of patients, but also improve the symptoms of patients and reduce the incidence of complications. It has high clinical value and application value. 2021 Vol. 28 (35): 231-233 [Abstract] ( 39 ) HTML (28 KB)  PDF  (0 KB)  ( 6 ) 234 Effect of trinity nursing on serum biochemical indexes and rehabilitation of children with hyperfebrile convulsion ZENG Ling Objective To observe the effect of the trinity nursing model on children with high febrile convulsions,serum potassium, serum sodium and other serum biochemical indicators and rehabilitation. Methods A total of 128 children with febrile convulsions in Jingzhou Second People′s Hospital from August 2018 to October 2020 were selected as the research objects, and they were divided into the control group and the study group according to random number table method, 64 cases in each group. The control group received routine care and the study group received trinity care. Serum biochemical indicators, serum neuron-specific enolase (NSE) and acid calcium binding protein (S-100β)concentrations and rehabilitation indicators between the two groups were observed and compared. Results After nursing,serum potassium, serum sodium and blood glucose in the study group were higher than those in the control group, the differences were statistically significant (P＜0.05). The concentrations of NSE and S-100β of the study group were lower than those of the control group, and the differences were statistically significant (P＜0.05). The hospitalization time, local muscle tonic twitching time, binocular gaze time, and convulsions disappeared time in the study group were shorter than those of the control group, the differences were statistically significant (P＜0.05); the recurrence rate of the study group was lower than that of the control group, and the difference was statistically significant (P＜0.05). Conclusion The use of trinity nursing in the nursing of children with high fever and convulsion can effectively improve the patients′ serum index, promote recovery, reduce recurrence, and protect the physical and mental health of children. 2021 Vol. 28 (35): 234-236转240 [Abstract] ( 34 ) HTML (31 KB)  PDF  (0 KB)  ( 7 ) 237 Influence of sound accompanied nursing mode on intestianal cleanliness of inpatients before colonoscopy WANG Fang WANG Jin-xiao▲ YANG Wen-xia Objective To explore the influence of the accompanying nursing mode before colon examination on the intestinal cleanliness of patients in hospital. Methods From September to December 2020, 200 inpatients with intestinal examination in the Affiliated Hospital of Binzhou Medical College were selected as the research objects. They were divided into the control group (100 cases) and the observation group (100 cases) by random number table method. The control group was guided by the traditional nursing mode of 3-sid oral education and current frequency education for intestinal preparation, while the observation group was guided by the traditional nursing mode accompanied by the nursing mode for intestinal preparation. The Boston bowel preparation scale (BBPS) score was used to compare the intestinal cleanliness of the two groups, and the adverse reactions and reexamination refusal of the two groups were observed. Results The total BBPS score in the observation group were higher than those in the control group, and the differences were statistically significant (P＜0.01). The passing rate of intestinal preparation in the observation group was higher than that in the control group, and the difference was statistically significant (P＜0.01). There were no significant differences in the occurrence of adverse reactions related to intestinal preparation and the rejection of reexamination between the two groups (P＞0.05). Conclusion The traditional nursing mode accompanied by nursing mode can improve the cleanliness and quality of intestinal preparation in inpatients before colonoscopy without serious adverse reactions. 2021 Vol. 28 (35): 237-240 [Abstract] ( 31 ) HTML (34 KB)  PDF  (0 KB)  ( 7 )

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