预防给药时机对产妇术后感染及新生儿胆红素水平的影响

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Abstract Objective To investigate the effect of Cefazolin administration at 0.5 h before cesarean section, skin incision and after omphalotomy on postoperative infection of parturients and bilirubin level of newborns. Methods A total of 90 parturient undergoing cesarean section in the Jingdezhen Maternal and Child Health Hospital from October 2018 to March 2021 were selected. According to random number table method, they were divided into group A (intravenous infusion of Cefazolin Sodium at 0.5 h before cesarean section), group B (intravenous infusion of Cefazolin Sodium at skin incision) and group C (intravenous infusion of Cefazolin Sodium after omphalotomy), 30 cases in each group. The intraoperative blood loss, operation time and the time of temperature returning to normal in the three groups were recorded. The levels of white blood cells (WBC), neutrophils (NE) and C-reactive protein (CRP) at 48 h after surgery,and the maximum and average values of neonatal bilirubin within 1～5 d after birth were compared among the three groups. The occurrence of postoperative infection and neonatal hyperbilirubinemia was recorded. Results There were no significant differences in intraoperative blood loss and operation time among the three groups (P＞0.05). The recovery time of body temperature in group A and group B was lower than that in group C, the difference was statistically significant (P＜0.05). The levels of WBC, NE and CRP in group A and group B were lower than those in group C, the differences were statistically significant (P＜0.05). The total incidence of postoperative infection in group A was lower than that in group B and group C, the difference was statistically significant (P＜0.05). The incidence of neonatal hyperbilirubinemia in group A was higher than that in group B and lower than that in group C, the incidence of neonatal hyperbilirubinemia in group B was lower than that in group C, the difference was statistically significant (P＜0.05). Conclusion Compared with administration immediately after omphalotomy, prophylactic administration at skin incision can better reduce the risk of postoperative infection, and it can improve level of neonatal bilirubin and decrease incidence of neonatal hyperbilirubinemia compared with administration at 0.5 h before surgery.

Key words： Prophylactic administration timing Cesarean section Postoperative infection Neonatal bilirubin level

Received: 13 August 2021

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