转移性去势敏感前列腺癌患者疼痛相关因素及其与预后的关系

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Abstract Objective To explore the relationship between pain related factors and prognosis in patients with metastatic castration-sensitive prostate cancer (mCSPC). Methods A total of 365 patients with mCSPC admitted to Pingxiang People′s Hospital from January 2014 to January 2020 were retrospectively selected as the research objects. Among these of 127 patients with cancer-related pain symptoms were included in the pain group, and another 238 patients without pain symptoms were included in the pain-free group. The general data and clinical indicators of patients in the two groups were compared to determine the pain related factors, and further logistic analysis was performed to determine the relationship between the related factors and pain. Progression-free survival (PFS) and overall survival (OS) of patients in the two groups were followed up, and the end of follow-up or patient prognosis and death were taken as the endpoint. Cox regression was used to analyze the relationship between pain symptoms and patient outcomes. Results The univariate analysis showed that Gleason grade score, serum PSA level, ALP level, lymph node involvement, bone metastasis and bone metastasis were related to the occurrence of pain in mCSPC (P＜0.05). The age, course, BMI, lesion diameter, and visceral metastasis between the two groups were not significant (P＞0.05). The results of the multivariate analysis showed that the Gleason grade score, serum PSA level, ALP level, lymph node involvement, bone metastasis, and the number of bone metastases were the risk factors for pain occurrence in mCSPC patients (P＜0.05).PFS and OS were shorter than painless groups in the pain groups, which were statistically significant (P＜0.05). Pain symptoms in mCSPC patients are an independent risk factor for disease progression and shortened overall survival time (P＜0.05). Conclusion The occurrence of bone metastasis and visceral metastasis, high histological grade Gleason score, and high level of tumor markers mostly suggest pain symptoms in patients with metastatic castration-sensitive prostate cancer, which is an independent risk factor for poor prognosis.

Key words： Prostate cancer Sensitive to castration;Transfer Pain Prognosis

Received: 28 May 2021

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