大黄浸泡液联合吲哚美辛栓预防ERCP术后胰腺炎的前瞻性、随机对照研究

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Abstract Objective To explore the application value of Rhubarb Soaking Solution combined with Indomethacin Suppository in the prevention of pancreatitis (PEP) after endoscopic retrograde cholangiopancreatography (ERCP). Methods A total of 160 patients undergoing ERCP who were admitted to the Jiangxi Pingxiang People′s Hospital from January 2019 to January 2021 were selected as the research subjects, the random number table was used to divide them into a control group and a study group with 80 cases each. Patients in the control group received conventional treatment combined with Indomethacin Suppository 30 min before operation, and in the study group, patients received conventional treatment combined with Indomethacin Suppository 30 min before operation and Rhubarb Soaking Solution in oral administration after surgery. The degree of abdominal pain, laboratory examination indexes, rehabilitation effect, PEP and the incidence of hyperamylaseemia were compared between the two groups. Results The degree of abdominal pain in the study group was milder than that in the control group, and the difference was statistically significant (P＜0.05).There were no significant difference in alanine aminotransferase (ALT), serum total bilirubin (TBil), and C-reaction before (CRP), or serum amylase (AMS) level before treatment in the two groups (P＞0.05). The ALT, TBil, CRP, and AMS levels of patients in the study group after treatment were lower than those of the control group, and the differences were statistically significant (P＜0.05). In the study group, the time of anal exhaust, defecation, and nausea and vomiting disappearing, and hospital stay were shorter than the control group, and the differences were statistically significant (P＜0.05). The incidence of PEP and hyperamylaseemia in the study group were lower than those in the control group, and the differences were statistically significant (P ＜0.05). Conclusion Rhubarb Soaking Solution combined with Indomethacin Suppository can effectively prevent the occurrence of PEP, relieve abdominal pain, protect liver function,reduce AMS level, and promote postoperative recovery.

Key words： Endoscopic retrograde cholangiopancreatography Rhubarb Soaking Solution Indomethacin Suppository Pancreatitis

Received: 12 May 2021

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