不同放疗剂量对晚期宫颈癌盆腹腔<1 cm的可疑阳性淋巴结的临床效果

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Abstract Objective To investigate the clinical effect of different radiotherapy doses on suspicious positive lymph nodes less than 1 cm in pelvic or para-aorta of advanced cervical cancer. Methods A total of 130 patients with advanced cervical cancer who were admitted to Jiangxi Maternal and Child Health Hospital from January 2017 to December 2018 with imaging showing that the maximum short diameter of pelvic and para-aorta lymph nodes were all less than 1 cm were selected as the study subjects. They were divided into Group A (65 cases) and Group B (65 cases) by random number table method. The prescribed dose of 55 Gy/25 f was given to the suspicious positive lymph nodes less than 1 cm, and the dose of 60 Gy/25 f was given to the suspicious positive lymph nodes less than 1 cm. Clinical effects, incidence of short-term and long-term adverse reactions and long-term efficacy were compared between the two groups. Results Total efficiency comparison between the two groups at the completion of radiotherapy and 3 months after the completion of radiotherapy, with no statistically significant difference (P＞0.05). The incidence of recent radioactive adverse reactions (grade I to Ⅱ radioactive enteritis, grade I to Ⅱ radiocystitis and grade I to Ⅱ myelosuppression) in the group B were higher than those in the group A, with statistically significant differences (P＜0.05). The incidence of long-term radioactive adverse reactions (grade I to Ⅱlate radioactive enteritis) in the group B was higher than that in the group A, with statistically significant difference (P＜0.05). Conclusion For patients with advanced cervical cancer, 55 Gy can well control the suspected positive lymph nodes of pelvic lymph nodes less than 1 cm, with less adverse reactions, and can better improve the quality of life of patients, which may be worthy of clinical reference and promotion.

Key words： Cervical cancer Lymph nodes Radiotherapy Radiation dose

Received: 28 July 2021

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