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2016 Vol. 23, No. 32
Published: 2016-11-18
 
 
4 Study of the establishment of human LOX-1 gene Pichia expression vector and its expression
LIU Jing;YU Tian-tian;CHEN Yu-hua;LI Jing-da;TAO Ya-ni;LI Ming-ying;WANG Xiao;CHEN Yong;CHI Yan
Objective To construct LOX-1 eukaryotic expression vector and screen high expression strain,lay the foundation for obtaining active recombinant LOX-1 protein in vitro.M ethods LOX-1 gene was amplified by PCR with the plasmid containing human LOX-1 gene as a template.After TA clone,LOX-1 gene was subcloned into eukaryotic expression vector pPICZαA to obtain pPICZαA-LOX-1 recombinant plasmid.After double digestion identification,the positive recombinant plasmid was electro transformed into Pichia pastoris X-33.Situ double membrane hybridization method was used to rapidly screen positive highly expressed strains.Finally,Western blotwas used to test its expression. Results LOX-1 recombinant expressed vector was constructed and highly expressed strain was screened out successfully.Western blot results showed that the LOX-1 recombinant protein was expressed in the cell culture supernatant after induction by methanol.Conclusion LOX-1 gene is expressed in Pichia pastoris cell supernatant.This study laies a foundation for obtaining active recombinant LOX-1 protein in vitro and studying its role in atherosclerosis.
2016 Vol. 23 (32): 4-6转10 [Abstract] ( 172 ) HTML (40 KB)  PDF  (0 KB)  ( 37 )
7 Effect and mechanism of Com pound C on the neurotoxic injury of Bupivacaine
LU Jun;JU You-ting;HU Yan-hui;CHEN Shou-lin;CAIJun-ying;LIChang
Objective To investigate the effect of Compound C on neurotoxicity injury of Bupivacaine and mechanism. M ethods Eighteen normalmale SD ratswere divided into 3 groups randomly,6 rats in each group.Normal group(group N):the rats were received intrathecal injection with normal 30μl and intraperitoneal injection with normal saline;2％ Bupivacaine group(group B):the ratswere received intrathecal injection with 2％Bupivacaine 30μl and intraperitoneal injection with normal saline.2％Bupivacaine combined with Compound C group(group B＋C):the ratswere received intrathecal injection with 2％Bupivacaine 30μl combined with intraperitoneal injection with 20 mg/kg Compound C.The thresholds ofmechanical pain were measured by using Von-Frey hair at 2 h,3 h,4 h,1 d,and 2 d after treatment,and motor function(MF)score was performed.The ratswere sacrificed 3 d after treatment and the expression of AMPK in the dorsal root ganglia of rats was examined by fluorescent quantitation PCR.Results 30 min after intrathecal injection with Bupivacaine,compared with the group N,the MF scores of the group B and group B＋C were increased obviously (P＜0.05),and the MF scores of the group B and group B＋C were recovered 4 h after treatment.1 d After intrathecal in jection with Bupivacaine,the thresholds ofmechanical pain decreased in group B,compared with those of group B＋C and group N(P＜0.05).The fluorescent quantitation PCR results indicated that,the expressions of AMPK in group B＋C was lower than that of the group B and group N(P＜0.05).Conclusion Compound C can attenuate the neurotoxicity injury of Bupivacaine,and themechanism may be that it inhibited the expression of AMPK and protected the neural cells.
2016 Vol. 23 (32): 7-10 [Abstract] ( 152 ) HTML (43 KB)  PDF  (0 KB)  ( 34 )
11 M olecular targeted therapeutic agents for anti-malignantmelanoma
CHEN Ru-bing;DING Bao-yue;WU Zhao-yong;SONG Jian-qin;BAIHai-ting;XU Ning-yin
Melanoma is one of themalignant tumors that have highly received recent attention in recent years.In view of the deficiency in effective treatment formetastaticmalignantmelanoma,it is of great importance to find amore effective drug.This paper focused on the current situation of targeted therapy in the treatment ofmelanoma.Although the targeted therapy still had many problems to be resolved,its development and improvement in the melanoma treatment should not be ignored and a good application prospect could be expected.Through consultation,analysis and summarization of a large number of relevant domestic and overseas researches on targeted therapies formelanoma in recent years, the targeted therapeutic agents for anti-malignantmelanoma that are still under research and achieve some progress as well as their features and existing problems are summed up,which provides ideas and methods to study the targeted treatment formalignantmelanoma.
2016 Vol. 23 (32): 11-13转86 [Abstract] ( 136 ) HTML (45 KB)  PDF  (0 KB)  ( 41 )
14 Research progress on the relationship between hyperuricem ia and coronary heart disease
LI Na;GAO Yue-qin
Hyperuricemia is a disease caused by purine metabolic disorder,in the excessive level of uric acid.It can cause gout,metabolic syndrome,nephropathy and coronary heart disease,etc..With the developmentof economic level and the continuous improvement of people′s living standards,themorbidity and mortality of coronary heart disease are rising year after year,which seriously affect human health.Hyperuricemia is the risk factors for coronary heart disease, therefore,the prevention and treatment of hyperuricemia to reduce the coronary heart disease inmorbidity andmortality, aremore and more getting the attention of the human.This article reviews the relationship between hyperuricemia and coronary heart disease.
2016 Vol. 23 (32): 14-16 [Abstract] ( 172 ) HTML (41 KB)  PDF  (0 KB)  ( 41 )
17 Feasibility and safety of laparoscope combined w ith choledochoscope for preservation of gallbladder in the treatment of cholecystolithiasis
YIN Xi-zhou;CHEN Shu-fang;ZENG Bi-cheng;DING Sheng-wen
Objective To explore the feasibility and safety of laparoscope combined with choledochoscope for preservation of gallbladder in the treatment of cholecystolithiasis.M ethods 78 patients with cholecystolithiasis from August 2014 to March 2016 in our hospitalwere selected and divided into the control group and the observation group according to the ID number of odd and even numbers,39 cases in each group.The control group was treated with choledochoscope,the observation group was treated with laparoscope combined with choledochoscope.The surgical indexes and postoperative recovery indicators were compared between the two groups.Results The operation time of the observation group was longer than that of the control group,with significant difference(P＜0.01).The amount of bleeding in the observation group was less than that in the control group,the diet recovery time,the gastrointestinal function recovery time, hospitalization time in the observation group was shorter than that in the control group,with significant difference(P＜0.01).There was no significant difference in the incidence rate of complication between the two groups(P＞0.05).The gallbladderwall thickness and gallbladder contractile function at 1,6,12months after operation in the observation group was better than that in the control group,with significant difference(P＜0.01).The scores of quality of life at 1,6,12 months after operation in the observation group was higher than that in the control group,with significant difference(P＜0.01).Conclusion The application of laparoscope combined with choledochoscope for preservation of gallbladder in the treatment of cholecystolithiasis is safe and feasible,which can promote the recovery of gallbladder function and improve the quality of life of patients after surgery,it isworthy of clinical popularization and application.
2016 Vol. 23 (32): 17-19转22 [Abstract] ( 154 ) HTML (42 KB)  PDF  (0 KB)  ( 24 )
20 Clinical com parative study on the difference between posthepatitic cirrhosis and alcoholic cirrhosis
ZHU Yi-hong;CHEN Jing-kui;RUAN Shi-chong
Objective To investigate the difference of clinicalmanifestation and laboratory examination index between posthepatitic cirrhosis and alcoholic cirrhosis.M ethods 20 definite caseswith posthepatitic cirrhosis received and treated by our hospital from September 2013 to September 2015 were selected as hepatitis group,and 20 definite caseswith alcoholic cirrhosis for treatment at the same period were selected as alcoholic group.The clinical manifestations and complications of the two groupswere analyzed using retrospective studymethod.Results The incidence rate of right upper quadrant abdominal pain,jaundice and hepatomegaly in alcoholic group was higher than that of posthepatitic cirrhosis group,and incidence rate of ascites and splenomegaly was lower than that of posthepatitic cirrhosis group;AST/ALT, valley aminoacyl transfer peptidase,triglyceride glycerol,cholesterol and serum uric acid value of alcoholic group was higher than that of hepatitis group;the incidence rate of spontaneous bacterial peritonitis in alcohol cirrhosis group was significantly higher than that in hepatitis group,while the incidence rate of liver and kidney syndrome,primary liver cancer and hepatic encephalopathy in hepatitis group was significantly higher than that in alcoholic group respectively. All the above-mentioned differencewas statistically significant(P＜0.05).Conclusion There are different clinicalmanifestation and characteristic in posthepatitic cirrhosis and alcoholic cirrhosis which provide reference for clinical differentiation.
2016 Vol. 23 (32): 20-22 [Abstract] ( 159 ) HTML (37 KB)  PDF  (0 KB)  ( 33 )
23 Evaluation value of red cell distribution w idth coefficient of variation (RDW-CV)for the prognosis in patientsw ith sepsis
YU Xiao-yun;CAI-Li;YANG Wei-sheng
Objective To investigate the value of red cell distribution width coefficient of variation(RDW-CV)for the prognosis in patients with sepsis.M ethods 120 patients with sepsis and with elevated RDW-CV treated from October 2014 to June 2016 were retrospectively analyzed and patients were divided into DW-CV＜13.5％group,13.5％-15.5％ group and＞15.5％group according to the admission time,then mean value of APACHE-Ⅱscore and mortality in the correspondingmortality was calculated respectively.The correlation of RDW-CV and APACHE-Ⅱscore was judged, and the related factors of death was analyzed using multivariate Logistic regression analysis,and prediction ability of each group was compared.Patients were increased group and decreased group according to dynamic change of RDWCV in the first and fifth days on admission to judge the impact factor of the dynamic change of RDW-CV onmortality. Results RDW-CV value and APACHE-Ⅱscore were higher,they had higher clinicalmortality in patients,RDW rising and APACHE-Ⅱscore＞15 pointswas an independent risk factor to predict themortality within 28 days,and the clinicalmortality in increased RDW-CV group in the first and fifth days on admission was significantly higher than that of the decreased group(P＜0.05).Conclusion RDW-CV value increasing degree and dynamic change trend can effectively predict the prognosis of patientswith sepsis to judge themortality rate,and especially for patientswith elevated RDWCV and APACHE-Ⅱscore＞15 points,themortality within 28 days for them is obviously increased.
2016 Vol. 23 (32): 23-25 [Abstract] ( 147 ) HTML (39 KB)  PDF  (0 KB)  ( 38 )
26 Influence of Naloxone on respiratory mechanics,lung function,oxygen metabolism and D-dimer in patientsw ith acute respiratory failure
XIONG Zhi-gang;KONGMei-bian
Objective To explore the Naloxone on respiratorymechanics,lung function,oxygen metabolism and D-dimer in patients with acute respiratory failure.M ethods 110 patients with acute respiratory failure treated by our hospital from January 2013 to August 2015 were selected as object.Patientswere randomly and evenly divided into observation group and control group.Control group was treated by conventional method,while observation group was treated with Naloxone on the basis of control group.After treatment,respiratorymechanics,lung function,oxygenmetabolism index and D-dimer level in patientswas detected and compared respectively.Results After 3 days and 5 days treatment,the respiratorymechanics,pulmonary function and oxygenmetabolism index between two groups had significant difference(P＜0.05);D-dimer level of improvement degree in observation group was significantly better than control group(P＜0.05). Conclusion Naloxone can obviously improve the respiratorymechanics,lung function,and oxygen metabolism and other index.It isworth to be popularized and applied in clinic.
2016 Vol. 23 (32): 26-28 [Abstract] ( 168 ) HTML (40 KB)  PDF  (0 KB)  ( 39 )
29 Prevention role of Am inophylline for CIN
YANG Zhang-li;JIA Xiao-yun;XU Jian;QIN Jian-hong
Objective To explore the prevention role of Aminophylline for contrast induced nephropathy(CIN).M ethods Clinical data of 60 caseswith cardiac insufficiency treated by department of cardiology of our hospital and given coronary angiography examination from February 2014 to March 2016 was analyzed.Patients were divided into two groups according to different treatmentmethod:control group(n=30)and treatment group(n=30).Scrwas detected before operation and after 24 h,48 h,72 h and GFR was counted in patients of two groups.Clinical effect and incidence rate of CIN of two groups was observed.Results There was no statistical difference of Scr and GFR before operation in two groups (P＞0.05),and therewas no statistical difference of Scr and GFR before and after operation in treatment group(P＞0.05). Scr of control group gradually increased with time,and GFR gradually decreased with time.Scr[(268.9±25.6)μmol/L, (272.8±29.4)μmol/L,(277.8±38.1)μmol/L]of treatment group after 24 h,48 h,72 h operation were lower than those of control group[(281.4±27.2)μmol/L,(292.6±30.2)μmol/L,(319.8±36.2)μmol/L],GFR[（106.5±10.5）ml/min,（104.3±9.8）ml/ min,（102.6±9.6）ml/min were higher than those of control group[（93.5±10.1）ml/min,（88.7±9.5）ml/min,(80.2±8.1)ml/ min](P＜0.05).The total effective rate of treatment group(100％)was higher than that of control group(90％)(P＜0.05). The incidence rate of CIN in treatment group(0)was lower than that in control group(5％)(P＜0.05).Conclusion Aminophylline used in patients given coronary arteriography can decrease the incidence rate of CIN,and has protective effect for renal function,it isworth to be promoted and applied.
2016 Vol. 23 (32): 29-31 [Abstract] ( 177 ) HTML (39 KB)  PDF  (0 KB)  ( 38 )
32 Clinical effect com parision of combined and doublem irror and totally laparoscope for gallbladder-protected lithotom y treating gallbladder stone
WU Hua-fei;HE Hai-qing
Objective To study the clinical effect of combined and doublemirror and totally laparoscope for gallbladder-protected lithotomy treating gallbladder stone.M ethods from January 2014 to August 2015,200 patients with gallbladder stone to our hospitalwere selected and they were divided into research group(n=100)and control group(n= 100)according to different surgical operation way.Research group was treated by laparoscope combined with choledochoscope while control group was treated by totally laparoscope for gallbladder-protected lithotomy.Operation time, blood loss,intestinal peristalsis recovery time and hospitalization days in two groupswas recorded,and the occurrence of postoperative complication was observed in patients.Results Operation time in research group was obviously shorter than that of control group,and blood losswas significantly less than that of control group,the difference was statistically significant(P＜0.05),but two groups of intestinal peristalsis recovery time and hospitalization days had no statistically significant difference(P＞0.05).After 12months,gallbladder wall thickness in research group was obviously smaller that of control group,while the gallbladder contraction function was obviously better that of control group,and there was a statistical difference(P＜0.05).The incidence of complication was 4％in research group,while it was 8％in control group,and there was a statistical difference(P＜0.05).After followed up for 6-12months,all patients recovered well and no recurrence cases.Conclusion The clinical effect of combined and doublemirror is good,fewer complications,and beneficial to maintain the integrity of the gallbladder and improve the function of the gallbladder.It is worthy of clinical promotion and application.
2016 Vol. 23 (32): 32-34 [Abstract] ( 176 ) HTML (41 KB)  PDF  (0 KB)  ( 32 )
35 Diagnostic and treatment value of emergency gastroscopy and common gastroscope for upper gastrointestinal hemorrhage
WANG Xiao-qin;DING Zhi-gang
Objective To compare the diagnostic and treatment of emergency gastroscopy and common endoscopy in upper gastrointestinal hemorrhage.M ethods Clinical data of 39 patients given emergency gastroscopy from September 2012 to September 2015 was retrospectively analyzed and the control group given common gastroscope for the same period,the etiology diagnosis rate,the bleeding rate and blood transfusion rate during operation of patients in two groups were observed and analyzed.Results The etiology diagnosis rate of the observation group was higher(89.74％vs 66.67％，χ2=6.093,P＜0.05);the bleeding rate and blood transfusion rate during operation were different(χ2=8.773,4.198, P＜0.05);no serious complications(perforation,massive hemorrhage,drug allergy,sudden death)occurred in both groups. Conclusion There was high value of emergency endoscopy in the diagnosis and treatment of upper gastrointestinal hemorrhage,the etiology diagnosis rate was high;hemostatic rate under scope is high;blood transfusion rate during operation was low which should be promoted and applied.
2016 Vol. 23 (32): 35-37 [Abstract] ( 163 ) HTML (36 KB)  PDF  (0 KB)  ( 33 )
38 The feasibility of Scopolam ine combined w ith Dexamethasone acute toxic pulmonary edema and influence of sym ptom s disappear time
ZHONG Jian-hua
Objective To investigate the feasibility of Scopolamine combined with Dexamethasone acute toxic pulmonary edema and influence of symptoms disappear time.M ethods 72 patients with ATPE given emergency treatment in our hospital from January 2012 to June 2016 were selected and they were randomly divided into the control group and the observation group,there were 36 cases in each group.The control group was treated with 5～10 mg Dexamethasone every time,the total dose in 24 h was 15～30mg and the observation group was treated with Scopolamine(intravenous infusion of 1～3 mg,15～30 min)combined with Dexamethasone.The treatment effect,symptom disappearance time and complication of the two groups were compared.Results The drug onset time and pulmonary edema disappearance time of the observation group were significantly shorter than those of the control group(P＜0.05).The cure rate of the observation group was significantly higher than that of the control group(91.67％vs 69.44％,P＜0.05),and the complication rate was significantly lower than the control group(5.56％vs 22.22％,P＜0.05).There was no significant difference in mortality between two groups(P＞0.05).Conclusion Scopolamine combined with Dexamethasone can effectively improve the cure rate of ATPE,with the characteristics of rapid onset,fast symptoms,less complications and so on,the higher the value of clinical application.
2016 Vol. 23 (32): 38-40 [Abstract] ( 137 ) HTML (37 KB)  PDF  (0 KB)  ( 42 )
41 Influence analysis of early artificial ventilation on the prognosis of patients w ith acute organophosphorus pesticide poisoning com p licated w ith respiratory failure
YANG Wei
Objective To study the influence of early artificial ventilation on the prognosis of patients with acute organophosphorus pesticide poisoning complicated with respiratory failure.M ethods 100 patients with acute organophosphorus pesticide poisoning complicated with respiratory failure treated by our hospital from January 2014 to March 2016 were selected as the research object,according to the principle of random distribution,the patients were divided into two groups,each group had 50 cases.The observation group was given early mechanical ventilation therapy while the patients with dyspnea and respiratory had not been stopped before tracheal intubation,the control group was given the delayed mechanical ventilation therapy while the patients in a coma and respiratory arrest after tracheal intubation in with consciousness.The effective time of rescue,mortality,ventilation time and the incidence of ventilator associated pneumonia were compared between two groups.Results The effective time of rescue in the observation group was (44.72±18.36)min,compared with the control group,the difference was statistically significant(t=8.738,P=0.000).The mortality rate(2％),the incidence of ventilator-associated pneumonia(8％)in the observation group were lower than the control group(χ2=4.891,5.741,P=0.027,0.017),the ventilation time[(73.54±12.90)h]in the observation group was significantly shorter than the control group(t=4.831,P=0.000).Conclusion The clinical treatment process of patientswith respiratory failure in acute organophosphorus pesticide poisoning,early artificial ventilation given in patients can effectively shorten the effective time of rescue in patients,reduce themortality,shorten the treatment time ofmechanical ventilation and can also reduce respiratorymachine related pneumonia,and it is beneficial to improve the prognosis.
2016 Vol. 23 (32): 41-43 [Abstract] ( 144 ) HTML (39 KB)  PDF  (0 KB)  ( 31 )
44 Relationship between the 5-HTTLPR gene polymorphism and the therapeutic effect of diabetic peripheral neuropathic pain
QIN Yong-zhang;XIAO Li-xia;KE Rui-qiong;HONG Shi-hua;LYU Wei-ming
Objective To explored the relationship between the 5-HTTLPR gene polymorphism and the therapeutic effect of Fluoxetine in the treatment of diabetic peripheral neuropathic pain.M ethods 48 patientswith diabetic peripheral neuropathic pain in ourhospital from January 2014 toMay 2015were selected and given Fluoxetine treatment for 8weeks. The PCR technology was used to examine the 5-HTTLPR gene polymorphism.Results There were 7,15 and 26 cases in L/L,L/S and S/S genotypes,respectively.The scores of SF-MPQ were(18.3±3.9)points,(22.8±4.6)points,and(25.4±5.4) points after treatment of L/L,L/S and S/S patients,compared with the scores of(45.3±5.2)points,(44.8±6.1)points and (45.7±4.9)points before treatment,respectively,with significant difference(P＜0.05).The corresponding reductions of SFMPQ was(26.2±3.7)points,(21.1±4.3)points and(20.6±5.1)points,respectively,and there was significant difference between after treatment and before treatment(P＜0.05).The reduction rate of L/L and L/Sgenomeweremore than 50％, and the reduction rate of L/L genotype was higher than that the other two genomes,with significant difference(P＜0.01). Conclusion 5-HTTLPR gene polymorphism may be associated with the effect of Fluoxetine in the treatment of diabetic peripheral neuropathic pain.
2016 Vol. 23 (32): 44-46 [Abstract] ( 144 ) HTML (38 KB)  PDF  (0 KB)  ( 38 )
47 Study of the relationship between serum Fractalkine and uric acid,blood lipid
XU Hai-bo;YAN Xiao-guang;ZHONGWei;WANG Kuan;TAN Li-yan
Objective To explore the relationship between serum Fractalkine levels and uric acid,blood lipid.M ethods 58 patientswith hyperuricemia(HUA)in our hospital from January 2015 to February 2016 were selected as the HUA group,32 healthy persons of the matching of age and residence in the same period were selected as the NC group. ELISA method was used to detect the level of serum Fractalkine in the two groups,and the other related biochemical indexes were determined by automatic biochemical analyzer.Results The level of serum Fractalkine in the HUA group was higher than that in the NC group,with significant difference(P＜0.01).The level of serum Fractalkine was positively correlated with uric acid and blood lipid(r=0.287,P＜0.01).Multiple linear stepwise regression analysis showed that serum uric acid was themost significant factor affecting Fractalkine(β=0.058,P＜0.01).Conclusion The level of serum Fractalkine is closely related to the level of uric acid,and whichmay be directly or indirectly involved in the pathological process of HUA and othermetabolic diseases.
2016 Vol. 23 (32): 47-49 [Abstract] ( 149 ) HTML (36 KB)  PDF  (0 KB)  ( 30 )
50 Study of the clinical app lication of three-column typing theory in tibial p lateau fractures
WEILin-wen;HUANG Yu-feng
Obejective To research the clinical effect of three-column theory in the operation of tibial plateau fractures. M ethods Sixty-five patients with tibial plateau fractures which admitted in Ningde Municipal Hospital Affiliated to Fujian Medical University from January 2014 to January 2015 were selected.According to the results of three-column typing,the appropriate surgical approach and methods of internal fixation were selected for the patients.1,3,6 months and 1 year after operation patients were given the regular physical examination.The operation time,the time of fracture healing and the HSSscore of 1 year after operation were statistically analyzed.Results Therewas 42 cases of single column fracture,20 cases of double column fracture,and 3 cases of three column fracture in the 65 patients.The operation time of patientswith single column fracture was(72.5±3.5)min,the operation time of patientswith double column fracturewas(90.6±4.7)min,and the operation time of patientswith three column fracture was(107.4±9.6)min,the operation time of the patients with different fracture classification had statistically significant difference(P＜0.05).There was no significant difference in fractuhre healing time among patientswith different fracture classification(P＞0.05).After one year of operation,the score of HSS knee in patientswith single-column fracture was(83.2±1.3)points,the score of patients with double column fracture was(75.3±1.2)points,and the score of patients with three-column fracture was (71.1±1.1)points,the scores of patientswith different fracture classification had statistically significant difference(P＜0.05).Conclusion Three-column typing theory is effective in guiding the treatment of tibial plateau fractures,the function of the knee joint is restored to different extent,but the recovery degree is still affected by the fracture classification.
2016 Vol. 23 (32): 50-52转55 [Abstract] ( 135 ) HTML (39 KB)  PDF  (0 KB)  ( 39 )
53 Treatment effect of old metatarsal fracturesw ith m ini-plate internal fixation combined w ith autogenous iliac bone graft
HUA Han
Objective To explore the combined effect of autogenous iliac bone graft and miniplate fixation in old metatarsal fractures.M ethods Eighty patientswith old metatarsal fractures admitted to the People′s Hospital of Dexing City from April 2014 to April 2016 were divided into two groups according to the different treatmentmethods.40 patientswith restoration and autologous iliac bone grafting were included into control group,based on the abovemeasures, 40 patients were given miniplate fixation in addition and were included into the study group.The treatment effect and the amount of bleeding,drainage volume,fracture healing time of patients were compared between two groups.Results There was no significant difference in the total effective rate between the two groups(P＞0.05).The blood loss of the study group was(308±128)ml,the postoperative drainage volume was(134±26)ml,and the fracture hedling time was (9±3)weeks,which were better than those of the control group[(428±176)ml,(196±31)ml,(12±5)weeks],the differences were statistically significant(P＜0.05).Conclusion For the old metatarsal fractures,mini-plate fixation with autogenous iliac bone grafthas a better effect in fixation and recovery.
2016 Vol. 23 (32): 53-55 [Abstract] ( 145 ) HTML (36 KB)  PDF  (0 KB)  ( 28 )
56 Clinical effect of m inimally invasive nail p lacement in the treatment of thoracolumbar vertebral com pression fractures
ZHOU Guo-jin;ZENG You-wen;ZHONG Sheng-tao
Objective To investigate the clinical effect of PPSF in the treatment of TLVCF.M ethods Eighty-four patients with TLVCF in Jinxian County People′s Hospital from June 2012 to June 2015 were selected,and they were divided into open group and minimally invasive group according to the treatmentmethods,42 cases in each group,they were treated with open and percutaneous pedicle screw fixation respectively.The treatment effect of patients in the two groups was compared.Results The operation time,length of incision,amount of bleeding and length of stay of theminimally invasive group were significantly less than those of the open group(P＜0.05).The VAS score and Oswestry disability index of theminimally invasive group were significantly lower than those of the open group(P＜0.05).There was no significant difference between the two groups in the vertebral anterior height ratio and the sagittal plane Cobb′s angle (P＞0.05).Conclusion In the treatment of TLVCF,PPSF and traditional open surgery with similar correction effect,but PPSF is less trauma,faster postoperative recovery,and conducive to the postoperative pain and improve the function of the back,it isworthy of recommendation.
2016 Vol. 23 (32): 56-58 [Abstract] ( 145 ) HTML (40 KB)  PDF  (0 KB)  ( 31 )
59 Kong Keshi need le w ith a cable tension w ith the app lication of the patella fracture
YANG Ming
Objective To explore and analyze Kong Keshineedle with a cable tension with the clinical curative effect of treatment of patellar fractures.M ethods 60 cases of patellar fracture patients from January 2014 to January 2016 in our hospital were selected,and randomly divided into observation group and control group,30 cases in each group.The observation group of patientswere given open reduction and Kong Keshi needle with a cable tension belt to treat,the patients of control group were taken conservative treatment,the therapeutic effect of two groups were compared.Results The observation group of patientswith length of hospital stay was(14.2±0.5)d,the crutches fields timewas(4.3±0.4)weeks, fracture healing was(4.6±0.6)months,length of hospital stay of control group was(24.3±0.5)d,the crutches fields time was(8.5±0.4)weeks,fracture healing timewas(7.6±0.4)months,the observation group were better than that of control group,with the significant difference(P＜0.05).The observation group of patients was 100.0％,the control group was 80.0％,with the significant different(P＜0.05).Conclusion Kong Keshi needle with a cable tension with patellar fracture with obvious therapeutic effect,fewer complications,simple and easy to operate,fast recovery,it isworth popularizing in clinical use.
2016 Vol. 23 (32): 59-61 [Abstract] ( 148 ) HTML (39 KB)  PDF  (0 KB)  ( 31 )
62 The effect of knee osteoarthritis on the hidden blood loss after total knee arthrop lasty
HEMin1PENG Bing-long;LIU Shui-hong;YANGHui-wen;TIAN Hui-jun;ZHANG Yong;GAO Zhi-zeng
Objective To explore the effect of imaging classification of knee osteoarthritis on occult blood loss after total knee arthroplasty,for providing clinical reference for the treatment of patients with total knee arthroplasty.M ethods 68 cases of patients treated by primary unilateral TKA in our hospital from August 2015 to July 2016 were selected.According to Kellgren and Lawrence imaging classification standard for grading,The relationship between imaging classification and invisible blood losswas analyzed,Ⅲclasswas 28 cases,Ⅳclasswas 40 cases.Results The amount of blood transfusion,blood transfusion rate,blood transfusion rate,total blood loss and hidden blood loss of gradeⅣwere significantly higher than those of gradeⅢ(P＜0.05).There was no significant difference in occult blood loss rate between the two groups(P＞0.05).Conclusion Preoperative imaging classification of patients undergoing total knee arthroplasty can help surgeons to evaluate perioperative bleeding,and do a good job in blood management,which is of great significance for the protection of the life safety of patients.
2016 Vol. 23 (32): 62-64 [Abstract] ( 160 ) HTML (41 KB)  PDF  (0 KB)  ( 35 )
65 Clinical study of neoadjuvant chemotherapy in locally advanced breast cancer
ZOU Yu-feng
Objective To analyze the therapeutic efficacy and safety of neoadjuvant chemotherapy in locally advanced breast cancer.M ethods 120 untreated caseswith locally advanced breast cancer inⅡb stage-Ⅲc stage treated by our hospital from June 2007 to June 2013 were selected and divided into two groups according to number random method. The control group(60 cases)of patientswas given CEF treatment,the observation group(60 cases)patientswas given TA treatment.The clinical efficacy and incidence of adverse reaction in patients between two groupswas compared respectively.Results The total effective rate of the observation group was 88.3％(53/60),and itwas higher than the control group(70.0％,42/60),and the difference was statistically significant(P＜0.05);in terms ofmolecular typing,survival rate, and incidence of adverse reaction,the observation group was significantly lower than the control group(P＜0.05).Conclusion Neoadjuvant chemotherapy in locally advanced breast cancer can effectively improve the clinical efficacy,and the incidence of adverse reactions is lower,it isworthy of promotion.
2016 Vol. 23 (32): 65-67 [Abstract] ( 130 ) HTML (40 KB)  PDF  (0 KB)  ( 37 )
68 Clinical effect of neoad juvant chemotherapy combined w ith the rep lacement of tumor-type artificial knee joint treating osteosarcoma around the knee joint
HUANG Hai
Objective To explore the clinical effect of neoadjuvant chemotherapy combined with the replacement of tumor-type artificial knee joint treating osteosarcoma around the knee joint.Methods From February 2003 to November 2014,30 patients with osteosarcoma around the knee joint inⅡBstage were diagnosed by piration biopsy.Patients were treated by neoadjuvant chemotherapy for 1-2 cycle before operation,and drugs included Doxorubicin,Cisplatin,high dose of Methotrexate and Ifosfamide,and patients were given extensive resection of tumor and tumor prosthesis rebuilt,they were given adjuvant chemotheapy for 4-5 cycle after operation.Treatment effect was observed.Results All 30 patients completed preoperative neoadjuvant chemotherapy,extensive tumor resection,replacement of tumor-type artificial knee joint and postoperative chemotherapy.Patientswere followed-up for 12-152months,average(58.10±45.51)months,4 patients(13.3％)had local recurrence,8 patients(26.7％)had pulmonarymetastasis,7 patients(23.3％)died and 23 patients(76.7％)survivied,22 patients(73.3％)survived tumor-free and 1 case(3.4％)survived with tumor,the overall 5-year survival rate was 69.6％.Postoperative pathological HuvosⅡlevel in 14 cases(46.7％),HuvosⅢlevel 16 cases (53.3％),HuvosⅢlevelwith better prognosis than HuvosⅡlevel（P＜0.05).Local recurrence caseswent amputation with no local recurrence at the end of follow-up,themean MSTS function score was(27.4±3.5)points after sixmonths operation.1-year survival rate of prosthesis was 93.3％, 5-year survival rate was 80.2％,average(55.4±47.5) months,the related complication of prostheses was 5 cases（16.7％）,including peri-prosthesis infection in 1 patient(3.3％),aseptic loosening of prostheses in 3 patients (10.0％),prosthesis fracture in 1 patient(3.3％).Conclusion Neoadjuvant chemotherapy combined with the replacement of tumor-type artificial knee joint treating osteosarcoma around the knee joint is an effectivemethod for osteosarcoma around the knee,can obtain good control of the tumor and limb function,also has lower incidence of complications.
2016 Vol. 23 (32): 68-72 [Abstract] ( 142 ) HTML (58 KB)  PDF  (0 KB)  ( 33 )
73 The study of the efficacy and safety of Lobap latin p lus Paclitaxel treating advanced non-small cell lung cancer
WEIShu-li;ZHU Mo-shou;LIU Zhen-hai;LIN Shu-mei;FENGQi-xiao
Objective To study the clinical efficacy of Lobaplatin plus Paclitaxel treating advanced non-small cell lung cancer,and to explore the clinical applicability.M ethods From March 2015 to June 2016,40 cases of new advanced non-small cell lung cancerwere collected as study object from Xiaolan Town in Zhongshan City of Guangdong Province and randomly divided into the control group and the observation group,each group had 20 cases.The control group was treated with Paclitaxel plus Carboplatin,the observation group was treated with Paclitaxel plus Lobaplatin.The clinical efficacy and the incidence of adverse reaction after treatment between two groups were compared.Results The total effective rate of the control group was 70.00％and itwas obviously lower than that of the observation group(95.00％),and the difference was statistically significant(P＜0.05).The incidence of adverse reaction of the observation group was obviously lower than that of the control group,the differencewas statistically significant(P＜0.05).Conclusion The efficacy of Lobaplatin plus Paclitaxel treating advanced non-small cell pulmonary cancer is notable,the incidence of adverse reactions is lower,which isworthy of clinical promotion and application.
2016 Vol. 23 (32): 73-75 [Abstract] ( 138 ) HTML (37 KB)  PDF  (0 KB)  ( 28 )
76 Clinical curative effect of Recombinant human vascular endothelial inhibition combined with Pemetrexed treating senile pulmonary adenocarcinoma and analysis of its influence on serum level of VEGF and T cell subgroup
ZHONG Jiu-hong;GUO Yu-ling;TIAN Qiu-hong;YU Feng WU Fang
Objective To study the clinical curative effect of Recombinant human vascular endothelial inhibition combined with Pemetrexed treating senile pulmonary adenocarcinoma and its influence on serum level of VEGF and T cell subgroup.M ethods 81 senile patientswith lung adenocarcinoma from March 2011 to April 2015 diagnosed in our hospital were admitted into study and they were randomized into two groups.The control group(n=40)was treated with Pemetrexed,while the observation group(n=41)was treated with Recombinanthuman vascular endothelial inhibition.Improvement of vascular endothelial growth factor(VEGF)and T cell subgroup(CD4＋T,CD4＋/CD8＋T and CD8＋T)between two groupswas compared respectively and clinical curative effect and drugmarrow suppression was compared respectively.Results Compared with control group,the observation group′s survival rate of 1 year and the total effective rate were both higher(P＜0.05).The index level of CD4＋T,CD4＋/CD8＋T increased with few changes of CD8＋T and the decrease of VEGF,while the observation group improved more significantly.The level of white blood cell,plateles, hemoglobin cut downmore significantly(P＜0.05).Conclusion Curative effect of Recombinant human vascular endothelial inhibition combined with pemetrexed treating senile pulmonary adenocarcinoma is distinct,with better prognosis,safe and reliable,which isworthy of promotion.
2016 Vol. 23 (32): 76-79 [Abstract] ( 133 ) HTML (47 KB)  PDF  (0 KB)  ( 40 )
80 Clinical study of styrofoam used to fix head,neck and shoulder in intensity modulated radiation therapy
HUANG Chun-lan;LIU Hua-zhi;HOU Liang;WANG Li-ping
Objective To explore the clinical value of styrofoam used to fix head,neck and shoulder in intensity modulated radiation therapy.M ethods 60 caseswith head and neck cancer treated buy our hospital from March to November 2015 and they were randomly divided into control group and research group,and each group had 30 cases.Conventional pillow and head and neck shoulder film fixation was used for fixing head and neck shoulder in control group,while styrofoam and head and neck shoulder film fixation was used in control group when radiotherapy.Clinical effect between groupswas compared.Results The repeatability(100.0％),conformal(100.0％)and comfort(96.7％)of the research group was higher than that in the control group(73.3％,66.7％and 66.7％)respectively,and the differenceswere statistically significant(P＜0.01).Conclusion Styrofoam used in radiotherapy of head,neck and shoulder with fixed position to provide a more comfortable,more adapted to head and neck type and having better repeated effect.Itmakes patients with head and neck cancer radiotherapy getmore comfortable and effectivemethod so as to ensure the smooth progress of its treatment.
2016 Vol. 23 (32): 80-82 [Abstract] ( 140 ) HTML (35 KB)  PDF  (0 KB)  ( 42 )
83 Clinical expression and significance of PrxⅠand PrxⅡfor patients w ith threatened abortion
YU Bi-ya;LIN Chun-yan;ZHONG Xiu-mei;YU Jin-sheng
Objective To study the clinical expression of PeroxiredoxinⅠ(PrxⅠ)and PeroxiredoxinⅡ(PrxⅡ)for patients with threatened abortion and explore the pathogenesis of threatened abortion from the aspects of oxidative stresss.M ethods Sixty patients with threatened abortion treated from April 2014 to April 2016 in the Huidong County People′s Hospital of Huizhou City were selected.30 cases of patients adopting the spontaneous abortion were selected as experimental group；30 cases of adopting the induced abortion were selected as control group.The specimen of decidua was collected.Through the immunohistochemicalmethod and western blot,the content of PrxⅠand PrxⅡfor spontaneous abortion and early pregnancy group was detected and compared.Results The positive rate of PrxⅠin the decidual tissues of the experimental group(40.0％)was lower than that of the control group(90.0％)；the positive rate of (＋＋)and(＋＋＋)in experimental group(6.7％,3.3％)was lower than those of the control group(53.3％,16.7％),the difference was statistically significant(P＜0.05).The positive rate of PrxⅡin the decidual tissues of the experimental group(40.0％)was lower than that of the control group(93.3％)；the positive rate of PrxⅡin the decidual tissues of the experimental group(40.0％)was lower than that of the control group(90.0％)；the positive rate of(＋＋)and(＋＋＋)in the experimental group(13.3％,3.3％)was lower than those of the control group(56.7％,20.0％),the difference was statistically significant(P＜0.05)；the expression of PrxⅠand PrxⅡprotein in the decidual tissues of the experimental group(0.217±0.018,0.224±0.021)was lower than that of the control group(1.174±0.114,1.184±0.181),the differences were statistically significant(t=31.942,29.481,all P＜0.05).Pearson correlation analysis showed that,the expression of PrxⅠprotein was positively correlated with PrxⅡprotein in the decidual tissues of the experimental group(r=0.782,P＜0.05).Conclusion The expression of PrxⅠand PrxⅡis positively correlated with each other and has the stronger oxidative stress.The loss of the proteinmay be themajormechanism of threatened abortion.
2016 Vol. 23 (32): 83-86 [Abstract] ( 132 ) HTML (45 KB)  PDF  (0 KB)  ( 31 )
87 Effect discussion of core stability exercisesin in postpartum patients w ith low back pain
GOU Yan-yun;JIANG Zheng;LUO Qing-lu
Objective To discuss the clinical effect of core stability exercises in postpartum patientswith low back pain. M ethods Forty postpartum patients with low back pain from January 2014 to January 2016 in Rehabilitation Hospital of Fujian University of Traditional Chinese Medicinewere selected and randomly divided into treatment group and control group,20 cases in each group.The ergonomic guidance was given in two groups,the treatment group was given core stability exercises about 6 weeks in addition,and according to their symptoms and functional level adjust the difficulty. Professional instruction was given once aweek,40minutes each time,self-training at least three times a week,each time 30 minutes.The assessment tools of numeric pain rating scale(NPRS),Roland-Morris disability questionnaire(RMDQ) and Oswestry disability index(ODI)were used to evaluate the clinical effect.Results The scores of NPRS,RMDQ and ODI in two groups posttreatment was lower than pretreatment.The difference value of NPRS,RMDQ in the two groups had statistically significant difference(P＜0.01).And the difference value of the ability of daily living,such as washing, taking off and putting on the clothes of the ODIscore in the two groups had statistically significant difference(P＜0.05). Conclusion Core stability exercises can improve the symptoms of low back pain in postpartum patients,and also promote the ability restoration of daily life.
2016 Vol. 23 (32): 87-89 [Abstract] ( 122 ) HTML (36 KB)  PDF  (0 KB)  ( 44 )
90 Analysis of genital tractm ycop lasma infection factors of puerperal infection after cesarean section
PENG Xue;TU Jian-bin;LU Zhao-xia
Objective To analyze the correlation between infection and puerperal infection in patients with genital tract mycoplasma infection after cesarean section combined treatmentmethod for clinical diagnosis and treatment.M ethods The clinical data of 261 patients with puerperal infection after cesarean section from January 2008 to December 2015 in Nanchang Integrated Traditional Chinese and Western Medicine Hospitalwere analyzed retrospectively.The results of laboratory examination of patients with culture and identification results of mycoplasma bacteria were observed and recorded,and the puerperal infection risk factors were analyzed;the correlation between risk factors of puerperal infec tion and culture resultswas analyzed.Results TheWBC countsand NUETwere increased in 180 cases(68.96％).84 cases (43.98％)had elevated serum CRP level.Only 1 risk factors were produced in 37 cases(14.18％).The results of pathogenic examination showed that 186 cases(71.26％)were positive formycoplasma culture,75 cases(28.73％)were positive for bacterial culture.In Mycoplasma positive cases,Mh positive in 107 cases(57.53％),Uu positive in 79 cases (42.47％);Staphylococcus aureus accounted for the largest proportion of the bacterial infection and the second one was Escherichia coli.The proportion of patients with duration of fever＞3 d in patients with Mycoplasma positive was significantly higher than that of bacteria positive(P＜0.05).Conclusion Mycoplasma infection gradually replaced bacterial infection and become themain reason in puerperal infection,themanagement and treatment ofmaternal pre pregnancy should be strengthen,and to avoid the impact of risk factors,reduce the incidence of puerperal infection after cesarean section.
2016 Vol. 23 (32): 90-92 [Abstract] ( 108 ) HTML (37 KB)  PDF  (0 KB)  ( 32 )
93 Viability of low gas abdom inal laparoscopic in the treatment of ectopic gestation after the IVF-ET
CHEN Xu-xuan
Objective To analyze the viability of low gas abdominal laparoscopic in the treatment of ectopic gestation after vitro fertilization-embryo transfer(IVF-ET).M ethods Forty-six cases of ectopic gestation pregnancy patients after IVF-ET concurrentwere selected from May 2011 to August 2015 in Puning Overseas Chinese Hospital,and 24 patients were given the low gas abdominal laparoscopic treatment(laparoscopic group),while the other 22 patientswere given the abdominal treatment(open surgery group).The operative time,blood loss,postoperative anal exhaust time,postoperative pain and mean hospital stay time of patients in the two groups were observed;and the pregnancy outcome of patients in the two groupswas followed-up.Results Patients of the two groupswere successfully operated,there was no patients in the laparoscopic group converted to open surgery.The mean operative time,anal exhaust time,postoperative pain time and the average length of stay of the laparoscopic group were significantly less than those of the open surgery patients [(25.5±8.5)min vs(44.6±8.4)min,(19.8±7.2)h vs(42.1±7.9)h,(8.9±3.1)h vs(12.2±2.8)h,(6.6±2.4)d vs(11.5±2.5)d, P＜0.01],and the intraoperative blood losswas also less than the open surgery group[(28.2±8.8)ml vs(56.9±9.1)ml,P＜0.05],patientswere full-term birth,miscarriage and without newborn deformities;themean gestational age of the laparoscopic group was(38.2±2.8)weeks,and the open surgery group was(38.5±2.5)weeks,had no statistically significant difference(t=0.3820,P=0.7043);the average weight of neonatal patients in the laparoscopic group was(3.25±1.15)kg,the surgery group was(3.53±1.17)kg,had no statistically significant difference(t=0.8181,P=0.4177);Apgar score of the laparoscopic group was(8.7±1.3)points,the open surgery group was(8.9±1.1)min,also had no statistically significant difference(t=0.5606,P=0.5779).Conclusion Low gas abdominal laparoscopic can shorter the operative time,decrease the bleeding and postoperative recovery time in the treatment of ectopic gestation after IVF-ET,also with high safety,has clinical feasibility.
2016 Vol. 23 (32): 93-95 [Abstract] ( 126 ) HTML (37 KB)  PDF  (0 KB)  ( 36 )
96 App lication value of Xpert M TB/RIF detection system in children pulmonary tuberculosis lavage fluid
PAN Xiao-qin;TAN Chuan-mei;TANG Hong-yan;DING Yi-yi
Objective To explore the application value of Xpert MTB/RIF in testing ofmycobacterium tuberculosis in bronchoalveolar lavage fluid.M ethods From April 2014 to April 2016,162 children with suspected tuberculosis in Department of Pediatrics of the First People′s Hospital of Changde were selected as the research objects,at the same time direct smear acid-fast stain,centrifugation-smear acid-fast stain and MTB/RIF test were used to detect the acid-fast bacillus in alveolar lavage fluid,and the positive rate of acid-fast bacillus of threemethodswas compared.Results Positive rate of direct smear anti-acid stain,centrifugation-smear acid-fast stain and Xpert MTB/RIF test were 14.8％, 29.6％,78.3％respectively.The positive rate of the centrifugation-smear acid-fast stain was higher than that of the direct smear anti-acid stain the positive rate,the difference was statistically significant(χ2=4.56,P＜0.05);compared with centrifugation-smear anti-acid stain method,the positive rate of the Xpert MTB/RIF test was higher than that of the centrifugation-smear acid-fast stain,the difference was statistically significant(χ2=16.32,P＜0.01).Conclusion Among the threemethods,Xpert MTB/RIF test is a technology,that rapid,convenient,and with high positive rate,it is worthy of clinical application.
2016 Vol. 23 (32): 96-98 [Abstract] ( 137 ) HTML (39 KB)  PDF  (0 KB)  ( 29 )
99 Clinical significance of the detection in immunoglobulin in CSF and oligoclone IgG band children w ith viral encephalitis
WENG Xiang;LAN Di-shi
Objective To study the clinical application value of cerebrospinal fluid immunoglobulin and oligoclonal zone detection in the diagnosis of infantile encephalitis viral infection.M ethods Forty children from June 2014 to June 2015 in Fuzhou Children′s Hospital of Fujian Province were selected as the study objects,and they were divided into the viral encephalitis group(25 cases)and non-encephalitis group(15 cases).The expression of albumin(Alb),immunoglobulin (IgG,IgA,IgM)in cerebrospinal fluid(CSF)of the two groupswere detected and compared;the immune globulin(Ig)in the oligoclonal zone(OCB)was detected by enzyme immune fixed electrophoresi,and the the expression of Ig in the OCB of the two groupswere compared.Results The Alb,IgG,IgA and IgM in CSF of the encephalitis group were(0.18±0.08)g/L, (35.55±18.65)mg/L,(2.46±1.64)mg/L,(0.98±0.32)mg/L respectively,and the non-encephalitis group were(0.16±0.08)g/L, (10.45±2.62)mg/L,(0.54±0.38)mg/L,(0.59±0.15)mg/L respectively;and the levels of IgG and IgA in the two groups had statistically significant difference(P＜0.05),however,the levels of Alb and IgM in the two groups had no statistically significant differences(P＞0.05).There were 3 cases of the encephalitis group with positive expression of Ig in the OCB,the positive rate was 12％,and the non-encephalitis group was 0％,the positive rate in the two groups had no statistically significant difference(P＞0.05).Conclusion Increased content of immunoglobulin IgG and IgA in CSF can be a biomarkers for diagnosis of children with viral encephalitis,which worthy of clinical application.Oligoclonal zone detection has a certain value for diagnosis of infantile viral encephalitis,needmore samples to further research．
2016 Vol. 23 (32): 99-101 [Abstract] ( 148 ) HTML (38 KB)  PDF  (0 KB)  ( 38 )
102 Clinical effect of normal saline irrigation in the treatment of acute sinusitis in children
HE Gui-jun
Objective To discuss clinical effect of normal saline irrigation in the treatment of acute sinusitis in children. M ethods From January 2014 to May 2015,76 patientswith acute sinusitis in our hospital clinic were randomly divided into observation group and control group,38 cases in each group.The two groupswere treated with the same conventional treatment,the observation group was treated with conventional therapy,and normal saline was used to flush the nasal cavity,at least 1 time a day.The clinical efficacy of two groups,themain symptoms(rhinobyon,rhinorrhea,headache)improvement time and treatment time were compared.Results Total effective rate in the observation group was 97.37％, highet than 84.21％in the control group.Themain symptoms improvement time and treatment time of the observation group was shorter than that of the control group,and the difference was statistically significant(P＜0.05).Conclusion Under the condition of conventional treatment,normal saline irrigation can improve the clinical efficacy of acute sinusitis in children and shorten the use time of antibiotics.
2016 Vol. 23 (32): 102-104 [Abstract] ( 122 ) HTML (41 KB)  PDF  (0 KB)  ( 36 )
105 Effects evaluation of Ranibizumab intraocular injection in treating wet age-related macular degeneration
ZENG Zhi
Objective To explore the effects of Ranibizumab intraocular injection in treating wet age-related macular degeneration(wAMD).M ethods 92(100 eyes)patients with wAMD in our hospital from January 2012 to January 2015 were selected and used Ranibizumab intraocular injection.Data of best corrected visual acuity,intraocular pressure, optical coherence tomography,indocyanine green choroidal angiography and multi focus ERG were recorded before treatment and after treatment for 1month,3,6 and 12months.The clinial effects of Ranibizumab in treating wAMD were evaluated.Results Before treatment,centralmacular thickness(CMT)by usingOCTmeasurementhad statisticalsignificance compared with CMT that after treatment for 1 month,3,6 and 12 months(P＜0.01).After treatment 12 months,41 eyes stopped to leak fluid,and no more leakage increased.The leakage area before treatment,after treatment for 3,6 and 12 months was respectively(11.34±6.10)mm2,(9.77±5.77)mm2,(8.76±5.46)mm2and(6.80±4.88)mm2,all of the leakage area obvious decreased after treatment,and the difference was statistical significance compared with before treatment (P＜0.05).Conclusion Using Ranibizumab in treating wAMD can alleviate macular edema effectively and improve the vision of patients and with little adverse effects.
2016 Vol. 23 (32): 105-107 [Abstract] ( 128 ) HTML (40 KB)  PDF  (0 KB)  ( 43 )
108 App lication value of SD-OCT and FFA in diagnosis of postcataract cystoid macular edema
FANG Ting-bing;YAN Hao;WU Xue-dan
Objective To explore application value of spectral domain optical coherence tomography(SD-OCT)and fundus fluorescein angiography(FFA)in diagnosis of postcataract cystoid macular edema(CME).M ethods Altogether 80(84 eyes)of patientswhowere treated with cataract surgeriesin our hospital from October 2014 to October 2015 were retrospectively studied.The fundus of patients at 1 week,4,12,24 weeks after cataract surgeries were observed,center macular thickness(CMT)of and lateral,bitamporal and nasal retina were detected by using SD-OCT;the incidence of CME at 12 weeks aftercataract surgerieswas recorded and detected by using FFA.Results Each preoperative and postoperative periods showed statistical difference(P＜0.01)through variance analysis;CMT values at 1 week,4,12,24 weeks after cataract surgerieswere obvious increased compared with the preoperative ones,with statistical difference(P＜0.01), themostobvious changesoccurred at12weeksafter cataractsurgeries.CME occurred respectively in 1 eye(1.19％),2 eyes (5.95％),6 eyes(7.14％),4 eyes(4.76％)at 1 week,4,12,24 weeks after cataract surgeries,among which themost obvious changes occurred at 12 weeks after cataract surgeries,among 6 eyes with CME occurring at 12 weeks after cataract surgeries,micro-cystic changeswere seen in 3 eyes,edema thickening between internal and external nucleus occurred in another 3 eyes.The retinal thickness in four quadrant before and after operation were analyzed by analysis of variance, and the difference was statistically significant(P＜0.01);retinal thickness in 3 quadrantwith bitamporal,above,below at 1 week,4,12,24 weeks after cataract surgeries compared with the preoperative was significantly thickened,and the difference was statistically significant(P＜0.05);nasal retinal thickness at 24 weeks after cataract surgeries compared with the preoperative,and the differencewas statistically significant(P＜0.05);at12 week after cataractsurgeries,change of retinal thicknesswas themost obvious.Therewas no significant difference between the incidence of CME detected by using SD-OCT and FAA at 12 weeks after cataract surgeries(P＞0.05).Conclusion SD-OCT can be used to observe the increase of the early-stage retina thickness in cataractmacular areas and themacular edemamorphology in a quick and accurate way;while themeasurement of FFA can be used to observe the leakage phenomenon.The observation results of cataract patientswith postoperative edema obtained by using twomethods are not completely consistent,but coordination of SD-OCT and FFA can serve as an effectivemeans for the diagnosis and assessment of CME.
2016 Vol. 23 (32): 108-111 [Abstract] ( 113 ) HTML (40 KB)  PDF  (0 KB)  ( 35 )
112 Clinicalapp lication ofsevofluraneanesthesia in pediatric strabismussurgery
SUN Bo;DING Zheng-nian;HEMing-feng
Objective To explore the clinicalapplication of sevoflurane static inhalation combined anesthesia and propofol total intravenous anesthesia in pediatric strabismus surgery.M ethods 60 children patients who conducted strabismus surgery from August 2014 to June 2016 in our hospital were selected.ASA grade was gradeⅠ,among that 26 cases were boys,34 cases were girls and the age from 2 to 6 years.Patients were average divided into propofol total intravenous anesthesia group(P group)and sevoflurane static inhalation combined anesthesia group(Sgroup)by random number table,30 cases in each group.Patients in P group were used propofol and fentanyl intravenous anesthesia induction and drug maintenance with propofol and remifentanil intravenous anesthesia.Patients in S group were used sevoflurane and fentanyl intravenous anesthesia induction and drug maintenance with sevoflurane and remifentanil intravenous anesthesia.The mean arterial pressure(MAP),heart rate(HR),postoperative extubation time(T0)and PACU residence time at before induction(T1),the beginning of tracheal intubation(T2),the beginning of operation(T3),15min in operation(T4)and the end ofoperation(T5)in twogroupswere compared.Results Theheart rate in Pgroup at thebeginning of tracheal intubation(T2),the beginning of operation(T3),15min in operation(T4)and the end of operation(T5)were respectively[(115±8)/min],[（110±7）/min],[（111±8）/min]and[（110±7）/min],which had statistical significances with those were respectively[(107±8)/min],[（106±8）/min],[（107±7）/min]and[(106±8)/min]in S group(P＜0.05).The postoperative extubation time(T0)was[(7.5±2.6)min]in Sgroup,shorter than thatwas[(9.4±2.7)min]in P group(P＜0.05). Conclusion Sevoflurane static inhalation combined anesthesia can stabilize heart ratio during operation,rapid extubate after operation and can be safely used in pediatric strabismus surgery.
2016 Vol. 23 (32): 112-114 [Abstract] ( 123 ) HTML (40 KB)  PDF  (0 KB)  ( 35 )
115 Effects of nalbuphine hydrochloride on tumor necrosis factor-αand interleukin-6 during one lung ventilation
ZHANG He;LIQing-chun;LONG Chao

Objective To explore the effects of nalbuphine hydrochloride on Tumor necrosis factor-α(TNF-α)and Interleukin-6（IL-6）for patients undergoing thoracoscopic lobectomy during one lung ventilation(OLV).M ethods Fortyfour patients were selected form April to August 2016,undergoned open radical esophagectomy and were randomly divided into two groups(n=22).One group was received intravenous infusion of nalbuphine hydrochloride 0.2 mg/kg (Group N)and theothergroupwasreceived thesamevolumeofsaline in thesameway(Group C)before inductionofanesthesia. Blood samples were collected before the anesthesia induction(T0),20 min after two lung ventilation（T1),at 30 min(T2), 60 min(T3)after OLV and 10 min after again two lung ventilation(T4)for determination of serum TNF-αand IL-6 concentrations.Results Comparedwith T0,the levelof TNF-αat T3,T4and the levelof IL-6 atT4were significantly increased in the two groups(P＜0.05).Compared with Group C,the level of TNF-αat T3,T4and the level of IL-6 at T4were significantly decreased in Group N(P＜0.05).Conclusion Intravenous nalbuphine hydrochloride 0.2 mg/kg before induction of anesthesia can inhibit the level of TNF-αand IL-6 and reduce inflammatory response in the patients undergoing thoracoscopic lobectomy with OLV.
2016 Vol. 23 (32): 115-117 [Abstract] ( 134 ) HTML (42 KB)  PDF  (0 KB)  ( 38 )
118 Exp loration of vaginal color ultrasound in the treatment of infertility by integration of traditional Chinese and W estern medicine
MA Liang-di
Objective To explore the application value of vaginal color ultrasound in the treatment of infertility by integration of traditional Chinese and Westernmedicine.M ethods From December 2014 to August 2015,120 cases of infertility treated by integration of traditional Chinese and Westernmedicine and admitted into our Department of Gynecology and Obstetrics were selected.Uterine and follicular development in all these participants weremonitored by vaginal color ultrasonography at regular intervals.Treatmentwas continued for one year at the same time in order to further observe the vaginal color Doppler monitoring and therapeutic effect.Results After treatment,the follicular diameter was (25.52±0.44)mm,which was better than(13.07±0.91)mm before treatment(t=134.9268,P＜0.05),the endometrial thicknesswasmuch better than thatbefore treatment(t=103.0617,P＜0.05),the follicle growth ratewas(1.60±0.37)mm/d,which was significantly faster than(0.78±0.41)mm/d before treatment(t=16.2650,P＜0.05).Normal ovulation was returned in all participants in different stages of treatment,and the pregnancy rate was 65.00％.Conclusion Vaginal color ultrasonography can be used to observe the changes of uterus,follicle diameter,endometrial growth rate and thickness in patientswith infertility treated by integration of traditional Chinese and Westernmedicine aiming at identifying the cause of infertility,observing the therapeutic effect,and predicting pregnancy,which isworth promoting.
2016 Vol. 23 (32): 118-120 [Abstract] ( 138 ) HTML (39 KB)  PDF  (0 KB)  ( 35 )
121 Value of MRI in the diagnosis of knee joint ligament injury
CHEN Li-qiang
Objective To explore diagnostic value of MRI in knee joint ligament injury.M ethods From January 2013 to April 2016,60 cases of suspected patientswith knee ligament injury in our hospitalwere selected as research object,all patients received MRIexamination,and the results of arthroscopy was set as the＂gold standard＂for diagnosis,the diagnostic sensitivity,specificity,accuracy,positive predictive value and negative predictive value of MRI in knee joint ligament injury were calculated,the diagnosis coincidence rate of MRI in anterior cruciate ligament,posterior cruciate ligament,lateral collateral ligament andmedial collateral ligament injurieswere calculated.Results The diagnostic sensitivity,specificity,accuracy,positive predictive value and negative predictive value of MRI in knee joint ligament injury was respectively 94.12％,88.89％,93.33％,97.96％,72.73％,the diagnosis coincidence rate of MRI in anterior cruciate ligament,posterior cruciate ligament,lateral collateral ligament and medial collateral ligament injuries was respectively 91.89％,94.44％,91.67％,90.00％.Conclusion In the diagnosis of the knee joint ligament injury,MRI technology is used to detect knee joint ligament injury and has the advantages of accurate diagnosis and noninvasive diagnosis.
2016 Vol. 23 (32): 121-123 [Abstract] ( 138 ) HTML (37 KB)  PDF  (0 KB)  ( 30 )
124 Investigation of the clinical effect of Dexamethasone combined w ith Urokinase in the treatment of tuberculous p leurisy
ZOU Xiao-xin;WANGMing-xue;SHUAILi-hua2
Objective To investigate the clinical effect of Dexamethasone combined with urokinase in the treatment of tuberculous pleurisy.Methods 50 patientswith tuberculous pleurisy from January 2014 to January 2016 in our hospital were selected,and were randomly dividied into the control group and the observation group,with 25 cases in each group. The control group was given thoracic injection of Dexamethasone,and the observation group was given thoracic injection of Dexamethasone combined with urokinase.The effective rate of treatment,the incidence of adverse reactions,the total volume of pleural effusion,the thickness of pleura,the disappearing time of pleural effusion and the quality of life of the patients before and after treatmentwere compared between the two groups.Results The effective rate of treatment in the observation group was higher than that of control group,and the incidence of adverse eventswas lower than that of control group(P＜0.05);the total volume of pleural effusion in the observation group wasmore than that of control group after the treatment,and the thickness of pleura and disappearing time of pleural effusion were less than those of control group.FEV1and FVC were better than those of control group(P＜0.05);there was no significant difference in the quality of life between the two groups before treatment(P＞0.05);after treatment,the quality of life in the two groups of patients were improved,and the improvement of life of quality in the observation group was better than that of control group(P＜0.05).Conclusion Dexamethasone combined with urokinase in the treatment of tuberculous pleurisy has significant effects,and is able to improve the disappearing time of patient′s clinical symptoms,and reduce adverse reactions,which is worthy of clinical promotion.
2016 Vol. 23 (32): 124-126 [Abstract] ( 123 ) HTML (45 KB)  PDF  (0 KB)  ( 38 )
127 Efficacy and toxicity analysis of several antidepressants in treating female patientsw ith depression
XIAO Xiang-ling
Objective To explore and compare antidepressantmedications commonly used in clinical efficacy and side effects of female patientswith depression analysis.M ethods 89 cases in our hospital for treatment of female depression patients from January 2014 to January 2016 were selected as the subject of and were randomly divided into four groups ofⅠ,Ⅱ,Ⅲ,Ⅳ,they were given Risperidone,Paroxetine,Venlafaxine,of Los paroxetine observation and treatmented for 12 weeks,before the treatment and on the 2,6,12 weeks,the effect were evaluated by Clinical Global Impression scale (CGI),Montgomery-Asberg depression Rating scale(MADRS),16 fast Xiang depression questionnaire(QIDS-C16)and 17-item Hamilton depression Rating scale(HAMD-17),the course of treatmentadverse drug reactionswas assessed by emergence of treatment symptom scale(TESS)and laboratory inspectionmethods.Results There were significant differences between the four groups after treatment(P＜0.05).Thereweremore insomnia in groupⅠthan thatof groupⅡ,and less nausea and vomiting than the other three groups.The weight gain wasmore than the other groups.The constipation of groupⅢ,ⅡandⅢweremore than that of groupⅠandⅣ,the differenceswere significant(P＜0.05).Conclusion Four kinds of antidepressant drugs for female depression,have different degrees of curative effect.The duloxetine drugs may work faster than other drugs.According to the specific circumstances of patients,targeted selection of appropriate drugs,can significantly improve the clinical cure rate and quality of life of patients to avoid patients with intolerable adverse reactions,reduce pain in patients.
2016 Vol. 23 (32): 127-129转132 [Abstract] ( 115 ) HTML (39 KB)  PDF  (0 KB)  ( 38 )
130 The clinical effect of M ethylprednisolone and Dexamethasone in treatment of sudden deafness
HE Bi-yun;ZHANG Zhu
Objective To explore the clinical effects of Methylprednisolone and Dexamethasone in treatment of sudden deafness.M ethods 98 patientswith sudden deafness and who accepted treatments in our hospital from September 2014 to September 2015 were selected as the research objects,and were divided into A and B two groups by the random number table methods.In the A group of 49 cases were applied the Methylprednisolone while in the B group of 49 cases were given the Dexamethasone treatment.Then,the treatment effect and adverse reactions of the two groups of patients were observed.Results The total effective rate in the two groups respectively were 95.92％and 83.67％,and the differences were significant(P＜0.01);before treatment,two groups had no significant difference in hearing threshold(P＞0.05). Improvement after treatment,the A group of 3,7 d threshold testwas better than B group after treatment,the difference was significant(P＜0.01);the incidence rare of adverse reactions in the two groups respectively were 14.29％,10.20％,the difference was no statistically significant(P＞0.05),and there was no serious adverse reactions.Conclusion In the treatment of sudden deafness,the clinical effect of Methylprednisolone is better than that of Dexamethasone,and the safety is high,thus it isworthy to be promoted.
2016 Vol. 23 (32): 130-132 [Abstract] ( 134 ) HTML (36 KB)  PDF  (0 KB)  ( 34 )
133 The research and safety analysis of Edaravone in accordance w ith the joint in Butyl phthalide capsule in the treatment on acute ischem ic stroke
LIANG Hai-shan;XIAO Cheng-nian;XIZhen-hua;HUANG Peng
Objective To explore the research and safety analysis of Edaravone in accordance with the joint in Butyl phthalide capsule in the treatment on acute ischemic stroke.M ethods 83 Patients with acute ischemic stroke from July 2012 to August 2015 in our hospital were selected and randomly dividied into the control group and treatment group. All the patientswere treated with routine treatmentaccording to the guide,while the control group(n=41)were accepted Edaravone in additon,and the treatment group(n=42)were cured with Butyl phthalide capsule on the basis of control group,14 days for a course of treatment.Before and after treatment in patientswith serum hypersensitive c-reactive protein(hs-CRP),tumor necrosis factor(TNF-α)the improvement of inflammatorymarkers were compared.The two groups would be also compared with nerve function(NIHSS score)to improve the situation,clinical curative effect and adverse drug reactions.Results After treatment,the level of the patient hs-CRP,TNF-α,NIHSS scores were lower than before treament,but the treatment group improved more significantly,and the total effective rate was higher,with significant difference(P＜0.05),the incidence of adverse reactions of two groups were low,with no siginificant differences(P＞0.05). Conclusion Curative effect of edaravone in accordance with the joint in phthalide capsule in the treatment on acute ischemic stroke is distinct,which can accelerate disease rehabilitation,inhibit inflammation,it isworth promoting.
2016 Vol. 23 (32): 133-135 [Abstract] ( 119 ) HTML (42 KB)  PDF  (0 KB)  ( 31 )
136 Safety of chronic oral-taking enalapril maleate and folic acid tablets in the treatment of H-type hypertension w ith chronic heart failure
QU Na CHENG;Xian-zhi;ZHENG Shuai;NA Li-sha
Objective To explore the safety of enalaprilmaleate and folic acid tablets in patientswith H-type hypertension complicated with chronic heart failure.M ethods 50 patients with H-type hypertension complicated with chronic heart failure from March 2014 to December 2015 were selected,on the base of regular treatment,they were taken enalaprilmaleate and folic acid tablets,the starting dose of 5.0mg/0.4mg,once every 2 weeks,the dose ofwas increased to the target dose or maximal tolerated.Treatment effect,blood pressure state,heart function and adverse drug reaction were observed before treatment and after treatment for 6 and 12 months.Results Clinical symptoms improved markedly in patients with H-type hypertension complicated with chronic heart failure after treatment for 6 and 12 months with enalaprilmaleate and folic acid tablets(P＜0.05);no significant adverse drug reactions,platelet hemoglobin liver kidney function had no significant influence.Conclusion Treatment with enalaprilmaleate and folic acid tablets for patients with H-type hypertension complicated with chronic heart failure canmarkedly improve the safety and survival rate.
2016 Vol. 23 (32): 136-138 [Abstract] ( 146 ) HTML (41 KB)  PDF  (0 KB)  ( 34 )
139 Effect of epidem iology and CD4+CD25+T cells on the pathogenesis of atopic dermatitis in Pingxiang area
WU Hai-hong;LIN Jia-kun;LIYun-hua;LIJie-mo;XU Yan-ping
Objective To understand the incidence of atopic dermatitis in children aged 6-13 years in Pingxiang area; on the basis of the expression level of CD4＋CD25＋T cell transcription factor Foxp3 in peripheral blood of patientswith AD,the role of this cell in the pathogenesis of AD was analyzed.M ethods AD prevalence rate questionnaire was set, from November to December in 2014 1600 pupils of 6-13 years old in Pingxiang area were chosen and investigated by stratified random samplingmethod,healthy children with age and sexmatched,and children with AD were selected and detected by flow cytometry,50 children in each group,the expression level of CD4＋CD25＋T transcription factor Foxp3 membranemolecule was calculated.Results Prevalence rate of 6-13 years old children with AD in Pingxiang area was 14.5％,higher than 10.2％of national average level;prevalence rate children in Pingxiang area was higher than that of rural children(χ2=4.63,P=0.042),there was no gender difference.Prevalence rate of＞10-13 years old children was lower than that of 6-10 years old children(χ2=5.36,P=0.039).The percentage of Treg(CD4＋CD25＋)cells of AD patientswas significantly lower than that of healthy children[(0.60＋0.18)％vs(5.95＋1.05)％],and the difference was statistically significant(t=2.306,P=0.028).Conclusion ADmay be related to environment,food sources,immunity,improving the environment and strengthening foodmanagement and so on can reduce prevalence rate of AD.
2016 Vol. 23 (32): 139-141 [Abstract] ( 127 ) HTML (46 KB)  PDF  (0 KB)  ( 31 )
142 Investigation on the status of cancer-related fatigue and quality of life in the digestive tract tumor patients
JIChao-fan;XIA Li-ming
Objective To investigate quality of life(QOL)and its influencing factors of cancer related fatigue(CRF)in patientswith digestive tract tumor.M ethods 100 patients with the digestive tract tumor were selected in Department of Oncology of the First Affiliated Hospital of Anhui University of Traditional Chinese Medicine were randomly selected from June 2014 to June 2016 and their scoresweremeasured by atigue self-assessment scale of Piper and QOL survey scale.SPSS software analysis was used.The general condition index,CRF index and QOL of the research objects were measured.Results The overall fatigue index was 5.26＋0.90,ofwhich there were 8 cases of no fatigue or slight fatigue,accounting for 8％;72 cases ofmoderate degree of fatigue,72％of the total,and 20 cases of severe fatigue,accounting for 20％.The overall score of CRFwas(117.92＋22.88)scores,4 subscale scores from low to high ranking,the highest for the behavior dimension was(33.23＋6.37)scores,followed by the cognitive dimension with(32.04＋6.43)scores,emotional dimension with(26.69＋5.59)scores,the lowest perceived dimension with(25.96＋4.73)scores,behavioral changes in CRF was themost obvious.Sleep quality and CRF degree was correlative,sleep quality wasworse,CRF degree wasmore serious,and the difference was statistically significant(F=6.700,P＜0.01);appetite condition and CRF degree was correlative, appetite condition wasworse,CRF degree wasmore serious,and the difference was statistically significant(F=9.609,P＜0.01);degree of pain and CRF degree was correlative,degree of pain was worse,CRF degree wasmore serious,and the difference was statistically significant(F=11.773,P＜0.01).Conclusion The Medical staff should pay close attention to patients′sleep,appetite and pain,and take targetedmeasures to improve QOL and the status of CRF in the digestive tract tumor patients.
2016 Vol. 23 (32): 142-145转149 [Abstract] ( 151 ) HTML (47 KB)  PDF  (0 KB)  ( 30 )
146 Analysis and preventive measures of the risk factors of hypertension in urban staff in Qian′an City
SONG You-wei;ZHANG Shi-qi;NING Chun-ping;ZHANG Qian-jin;ZHANG Xiao-jing;YIN Zhi-feng;SHAO De-ming;LIChun-liang;MEIYing-chun;LIXiao-jiang
Objective To analyze the risk factors of hypertension of workers in Qian′an City and discuss the corresponding prevention countermeasures.M ethods From October 2007 to September 2012,3987 patients with hypertension diagnosed in our hospitalwere conducted a questionnaire survey,and health recordswere established,patientswere popularized related knowledge with hypertension,the combination of personalized guidance and community health education was carried out,related risk factorswere analyzed.Results With the increase of age,the incidence of hypertension was on the rise,the prevalence rate of hypertension in male from over 25 to 45 years old was higher than that in female;the prevalence rate of hypertension in female over 55 years old was higher than that inmen(P＜0.05).Age,overweight,blood glucose abnormalities,dyslipidemia,hyperuricemiaweremajor risk factor of hypertension(P＜0.05);proportion of smoking and drinking,especially long-term drinking,high salt diet,lack of exercise in patientswith hypertension were significantly increased,and the difference was statistically significant(P＜0.05).After implementing the correct health guidance,the treatment rate and control rate of hypertension were significantly increased(P＜0.05).Conclusion Hypertensives who work in Qian′an City generally have an unhealthy lifestyle,incorrect cognitive attitude to hypertension.Therefore,it is time to actively promote the standardized management,scientific health guidance,improve hypertension treatment and control rates to reduce the happening of cardiovascular events.
2016 Vol. 23 (32): 146-149 [Abstract] ( 145 ) HTML (44 KB)  PDF  (0 KB)  ( 34 )
150 Analysis of 130 cases w ith adverse drug reactions in children and the guidance of drug use
MU Jing
Objective To explore the occurrence regularity and characteristics of adverse drug reaction(ADR)in children,and to provide guidance for clinicalmedication.M ethods The report of 130 cases of pediatric ADR collected in our hospital from July 2015 to July 2016 were selected,different types of drug,drug administration and clinicalmanifestations of ADR were compared and analyzed.Results In terms of gender and age,constituent ratio of women was 52.31％,little higher than 47.69％ofmen,the highest proportion of the age group was 1-3 years old(36.92％).In term of drug types,the highest proportion was antibiotic(38.63％),which was followed by traditional Chinesemedicine(25.00％). Thehighestpercentageof ADR resulted from antibiotics(48.46％),and the second highestwas traditionalChinesemedicine (32.31％).In terms of drug administration,the highest percentage of ADR resulted from intravenous injection(70.00％).In termsof clinicalmanifestation,the incidence of digestive system injurywas the highest(41.53％).Conclusion The strengthening of the prevention work,rational use of drugs and safemedication can decrease the occurrence of ADR.
2016 Vol. 23 (32): 150-152 [Abstract] ( 130 ) HTML (36 KB)  PDF  (0 KB)  ( 35 )
153 Influence of health know ledge intervention on know ledge of infectious disease related know ledge in urban and rural primary school students
XIONG Shu-wei
Objective To study the intervention of health education on the knowledge of infectious diseases in urban and rural primary school students,and to summarize the influence of intervention on the knowledge of the infectious diseases.M ethods 800 students at 8 primary schools in the Xihu District urban and rural areas were selected as research object from January 2013 to January 2014,by questionnaire survey of the major infectious diseases,infectious disease knowledge needs of studentswere understand and the corresponding knowledge education were conducted,master degree on the knowledge ofmajor infectious diseases were observed before and after intervention.Results Among 800 students,67.50％of students were familiar with the flu transmission channel,only 23.50％of students reported to teachers after infection;31.13％of students thank that school to strengthen infectious disease knowledge education was very important,but 40.13％of studentswere ignored.Before intervention,master degree of basis knowledge for flu,adherence to good health habits,timely isolation and treatment and condition for performance was 64.88％,62.13％,64.00％, 68.63％,with 89.88％,89.13％,90.75％and 94.50％respectively after intervention,the intervention resultwas significantly increased after intervention,and the difference was statistically significant(P＜0.01).Conclusion Themajor health educations are involved with the flu transmission channel,incubation period,treatmentmethods,timely report and isolation. The student′s parents shall also take the health education.After intervention,the student′smaster degree on the knowledge of flu is improved.
2016 Vol. 23 (32): 153-155 [Abstract] ( 128 ) HTML (37 KB)  PDF  (0 KB)  ( 32 )
156 Analysis of the epidem iological characteristics of hepatitis A from 2005 to 2015 in Shenyang City
SUN Ying-chun
Objective To analyze the characteristics and trend of incidence of hepatitis A in Shenyang City,and provide scientific basis for health department to formulate measures for the controlling hepatitis A.M ethods Descriptive epidemiology was adopted for the analysis of incidence of hepatitis A from 2005 to 2015 in Shenyang City.Results Therewerea totalof1706 casesofhepatitisA reported from 2005 to2015 through InfectiousDiseasesReporting Information Management System.The average annual reported incidence(AARI)of hepatitis A was 2.01/100,000;a significantly upward trend of incidence of hepatitis A was seen after 2012.The AARIof hepatitis A was 2.51/100,000 inmale,while itwas 1.49/100,000 in female.The casesweremainly distributed in 20-55 age groups,accounted for 79.19％of the total cases;the AARI of hepatitis A was lower in 0-15 age groups than other groups.Among all cases,the proportion of the housework and unemployee was the highest(36.18％),followed by the official staff(15.65％);no case was found in the fisherman,childcare worker and nanny.There was an obvious season peak for the incidence of hepatitis A.Infections mainly occurred from March to July,accounted for 58.79％of the total cases;the incidence was less in October, November and December,respectively accounted for 3.75％,3.81％and 3.87％.The AARIs of hepatitis A in the urban districtwere the highest,followed by the suburbs and the lowest in the county.Conclusion The hepatitis A in Shenyang City was still serious,health education and vaccination should be given to the high risk areas and susceptible population.
2016 Vol. 23 (32): 156-158 [Abstract] ( 117 ) HTML (39 KB)  PDF  (0 KB)  ( 34 )
159 Application and effect analysis of standardization of the key management system in the psychiatric ward
LIYin-e;XU Li;DU Ying;RONG Cai-lian
Objective To explore the application and effect of standardization of the key management system in the psychiatric ward.M ethods A department in our hospital from January to June 2016 was randomly selected as the pilot, the decentralized managementmode in the pastwas changed,and the key centralized management of the ward was given,and the departmentwas selected as the research group.At the same time,according to themedical staff education,the number,sex and other matching,the use of distributed key managementmodel of another section was selected as the control group.The incidence rate of key management problems of staff for 6 months,the incidence rate of key related adverse events in the two groups were compared.Results The incidence rate of key management problems in the research group was 5.0％,which was lower than 32.5％in the controlgroup,with significant difference(P＜0.01).The incidence rate of related adverse events in the research group was 1.0％,which was lower than 12.0％in the control group,with significant difference(P＜0.05).Conclusion The implementation of standardization of the keymanagement system in the psychiatric ward can greatly improve the quality of clinical care,reduce the key related adverse events,it is worthy of clinical promotion and application.
2016 Vol. 23 (32): 159-161 [Abstract] ( 128 ) HTML (38 KB)  PDF  (0 KB)  ( 41 )
162 Im p lementation and value research of nursing performance management of neurosurgery
HUANG Ren-e;WANG Hai-ying;LIZhen-zhen;TAN Yuan;TANWen-jing
Objective To explore the neurosurgery nursing implementation of performancemanagement and value of research.M ethods Nursing performancemanagementwas implemented in our hospital from January to December in 2015, and nursing performance management was not implemented from January to December in 2014.Nursing performance management included nursing workload,job level,patient satisfaction,quality of nursing work,etc..Business ability,quality of care and patient satisfaction scores were compared before and after the implementation.Results The business ability score and nursing quality score of nursing staff after performance nursingmanagementwas higher than that before the nursing performancemanagement,with significant difference(P＜0.05).The nursing satisfaction score of nursing staff after performance nursingmanagementwas(97.36±2.36)points,which was higher than(88.36±3.98)points before the performancemanagement,with significant difference(t=17.3972，P=0.0000).Conclusion The performancemanagement system of nursing in the department of neurosurgery of our hospital can enhance nursingmanagement,effectivelymobilize nurses′working enthusiasm,exert their creativity and initiative,and which can improve their own quality,professional ability, nursing quality and patient satisfaction,it isworthy of clinical popularization and application.
2016 Vol. 23 (32): 162-164 [Abstract] ( 131 ) HTML (38 KB)  PDF  (0 KB)  ( 42 )
165 App lication of clinical pathway teaching method in operation room nursing teaching
LUOWei-fang;ZHANGChao-hong;LIU Yu-er;MAWan-yi;LIN Ze-hua;MAIJing-nan
Objective To explore the application effect of clinical pathway teaching method in operation room nursing practice teaching.M ethods 86 nursing students practiced in operation room of our hospital from January 2014 to March 2015 were selected and randomly divided into the observation group and the control group,and each group was 43 cases.The observation group was given clinical pathway teaching method,and the control group was given traditional teachingmethod.After practice,the theory achievement for graduate from department,operation performance for graduate from department and teaching satisfaction in the two groupswere compared.Results The achievement theory and operation performance for graduate from department in the observation group was higher than that in the control group,with significant difference(P＜0.05).The degree of teaching satisfaction in the observation group was 95.43％,which was higher than 74.41％in the control group,with significant difference(P＜0.05).The working attitude,the basic operation skills of the operation room,the degree of surgical coordination skill and the degree of satisfaction with the teachingmethod in the observation group was better than that in the control group,with significant difference(P＜0.05).Conclusion Using clinical pathway teachingmethod in teaching can enhance the clinical nursing teaching quality of operation room,and nurse students are satisfied with teaching.
2016 Vol. 23 (32): 165-167 [Abstract] ( 124 ) HTML (39 KB)  PDF  (0 KB)  ( 31 )
168 Application evaluation of PDG and CBL Teaching Methods in Probationary Teaching of Endocrinology
WENG Yang;LIChun-li;TANG Yin-si;ZHENG Fang-ping;SONG Yu-ling;ZHOU Yi-jun
Objective To investigate the effects of PDG and CBL teaching methods in probationary teaching of endocrinology.M ethods A total of 120 studentsmajored in clinicalmedicine of 2013 grade,China Medical University were selected and randomly divided into two groupswith 60 students in each groups.The students of experimental group were taught with PDG＋CBL teaching methods.The students of control group were taught with traditional teaching methods. From July 2015 to June 2016,two groups of students were given endocrinology clinical probation teaching,after the internship,the effect of the two teachingmethodswas evaluated by theory examination,operation assessment,and questionnaire analysis.Results The theory knowledge,comprehensive abilities in the experimental group were significantly higher than those of control group,with differenceswere significant(P＜0.01).The experimental group got higher satisfaction in teaching than that of control group,the difference was significant(P＜0.05).Conclusion Effects of teaching with combination of PDG and CBL teachingmethods havemore advantages than the traditional teachingmethods in probationary teaching of Endocrinology.
2016 Vol. 23 (32): 168-170转173 [Abstract] ( 130 ) HTML (40 KB)  PDF  (0 KB)  ( 29 )
171 Influence of mental nursing on quality of life of patients w ith malignant tumor in oral and maxillofacial surgery
PAN Li-zhen;ZHENG Xiao-yan;ZHAO Fang-rong
Objective To analyze the psychological status of patients with malignant tumor in oral and maxillofacial surgery,and to explore the influence of psychological nursing on the life quality of patientswithmalignant tumor in oral andmaxillofacial surgery.M ethods49 patientswithmalignant tumor oforalandmaxillofacial surgery from February 2013 to February 2016 in our hospitalwere selected as the research subjects,the incidence of anxiety and fear,and the quality of life scores were investigated,and the satisfaction degree of patients to nursing were investigated.Results 49 patients had psychological problems of different aspects anxiety,fear,denial and doubts,despair,dependence,the incidence rate of nursing psychological problems in all aspects decreased significantly after nursing,the differences were statistically significant(P＜0.01).The scores of physical function,role function,emotional function,cognitive function and social function of patients after nursingwas higher than those before nursing,with significant difference(P＜0.05).In the 49 patients,21 cases(42.86％)were very satisfied,18 cases(36.73％)were satisfactory,8 cases(16.33％)were in general,and 2 cases(4.08％)were not satisfactory,the total satisfaction rate was 95.92％.Conclusion In the treatment process ofmalignant tumor in oral and maxillofacial surgery,there are the adverse psychologicalmood such as anxiety,fear,dependence of different degree and types,psychological nursing is important to improve the psychological status of patients and improve the quality of life of patients.
2016 Vol. 23 (32): 171-173 [Abstract] ( 116 ) HTML (37 KB)  PDF  (0 KB)  ( 29 )
174 Influence of humanized nursing on nursing satisfaction of outpatients
XIONG Rui-juan
Objective To explore the influence of humanized nursing on the nursing satisfaction of outpatients.M ethods 100 outpatients received routine nursing service in our hospital from January to June in 2015 were randomly selected as the controlgroup,and after the 28 outpatientnursing staff accepted the humanized nursing quality training,100 outpatients accepted the humanistic nursing in our hospital from July to December 2015 were randomly selected as the observation group.Nursing satisfaction and the incidence rate of nurse patient disputes in the two groups were compared.Results The nursing satisfaction of the observation group was 98％,which was higher than 81％of the control group,with significant difference(P＜0.05).The incidence rate of nurse patient disputes in the observation group was lower than that in the control group,with significant difference(P＜0.05).Conclusion Humanized nursing service has a good effect on the improvement of nursing satisfaction of outpatients.
2016 Vol. 23 (32): 174-176 [Abstract] ( 132 ) HTML (37 KB)  PDF  (0 KB)  ( 43 )
177 Influence of com prehensive nursing intervention on life quality and postoperative com p licationsof patientsw ith liver cancer in interventional therapy
WANG Ji-hong
Objective To explore the influence of comprehensive nursing intervention on life quality and postoperative complications of patients with liver cancer in interventional therapy.M ethods 128 patients with intermediate and advanced primary liver cancer in interventional therapy from January 2014 to December 2015 in our hospitalwere selected and randomly divided into the observation group and the control group,64 cases in each group.The control group was given routine nursing measures,and the observation group was given comprehensive nursing intervention.The score of life quality and the incidence rate of postoperative complication in the two groups were compared before and after intervention.Results The incidence rate of complication in the observation group was 4.69％,which was lower than 15.62％in the control group,with significant difference(P＜0.05).The scores of life quality of the two groups after intervention was higher than that before intervention,with significant difference(P＜0.05).The scores of life quality in the observation group after intervention was higher than that in the control group after intervention,with significant difference (P＜0.01).Conclusion The comprehensive nursing intervention measures can significantly reduce the incidence rate of postoperative complications,and improve the life quality of patients with liver cancer in interventional therapy,and it is worthy of clinical popularization and application.
2016 Vol. 23 (32): 177-179 [Abstract] ( 140 ) HTML (37 KB)  PDF  (0 KB)  ( 39 )
180 Nursing analysis of infertility due to fallopian tube obstruction treated w ith integrated traditional Chinese and W estern medicine
YU Hong-lan
Objective To explore the nursing effect of combining traditional Chinese and Western medicine on treating infertility caused by fallopian tube obstruction.M ethods 74 patients with infertility due to tubal obstruction from September 2014 to February 2015 in our hospital were selected and randomly divided into the control group and the observation group,37 cases in each group.The control group was given conventional therapy and conventional nursing, the observation group was given traditional Chinesemedicine treatment and corresponding nursingmeasures on the basis of the control group.The pregnancy and dysmenorrhea improvement after therapy for one yearwere compared in both groups.Results The total improvement rate of dysmenorrhea in the observation group was 97.3％,which was higher than 78.3％in the control group,with significant difference(P＜0.05).The pregnant rate of the observation group was higher than that of the control group,with significant difference(P＜0.05).Conclusion Application of integrated traditional Chinese and Western medicine in the treatment of infertility due to fallopian tube obstruction can obtain a definite effect,and which can remarkably increase pregnancy rate and dysmenorrhea improvement rate.
2016 Vol. 23 (32): 180-182 [Abstract] ( 118 ) HTML (38 KB)  PDF  (0 KB)  ( 27 )
183 Effect of comprehensive nursing intervention on the quality of long range video EEG monitoring
WENWei;ZHANG Chun-ying;ZENG Hai-lan;YANG Rui-jin
Objective To explore the application and effect of comprehensive nursing intervention in improving the analysis of video EEG monitoring in patients with comfort level.M ethods 128 cases of paroxysmal diseases from June 2014 to June 2016 in our hospital were selected and were randomed allccation,the control group patients were given routine nursing,the observation group were received comprehensive nursing intervention,nursing adverse events,eyes test,hyperventilation test success rate and nursing comfort of two groups were compared.Results The electrode loose of observation group was 3.13％,lead offwas 1.56％,wire damage rate was 1.56％,compared with the control group,the differences were significant(P＜0.05);the eyes test,nursing satisfaction hyperventilation test success rate and inspection process of ratio were compared with the control group,the differences were significant(P＜0.05).Conclusion The long term video EEGmonitoring in patientswith systematic evaluation and comprehensive nursing intervention can not only help improve the comfort level of patients with long range video EEGmonitoring,but also help to reduce the incidence of adverse events,improve the success rate of the examination,isworth promoting.
2016 Vol. 23 (32): 183-185 [Abstract] ( 129 ) HTML (44 KB)  PDF  (0 KB)  ( 39 )
186 App lication of clinical nursing pathway in coronary stent intervention
ZHANG Xiao-qin
Objective To explore on nursing effect of clinical nursing pathway in coronary stent implantation.M ethods 110 cases of patientswith percutaneous coronary intervention in our hospital from November 2015 to October 2016 were selected as the research object,the subject according to the random number table method were randomly divided into control group(55 cases)and observation group(55 cases),patients in the control group were treated by traditional nursing,patients in the observation group were treated by clinical nursing path,the number of days of hospitalization,nursing satisfaction and the incidence of complications of patients observation group and control group were compared.Results The hospitalized days of control group was longer than that of observation group;satisfaction rate of observation group was better than that of control group;adverse reactions incidence of observation group was lower than that of control group;with the differenceswere significant(P＜0.05).Conclusion Application of clinical nursing pathway in patients after PCI can reduce the patient hospitalization time,reduce the incidence of adverse reactions,improve patient satisfaction,the effect is significant,it isworthy of popularized after PCI implantation.
2016 Vol. 23 (32): 186-188 [Abstract] ( 114 ) HTML (42 KB)  PDF  (0 KB)  ( 30 )
189 Effect of Doula delivery mode on delivery mode,mental state and delivery outcome ofmaternal
HONG Qun-hui;CHENGMan-qin
Objective To investigate effect of doula delivery mode on delivery Mode,mental state and delivery outcome of Maternal.M ethods 200 cases of expectantmothers from May 2015 to July 2016 in our hospital were selected and randomly divided into research group and control group,100 cases in each group.Control group were treated with basic routine care,while research group were treated with Doula deliverymode care.Themode of delivery,mental status score, postpartum hemorrhage,labor time and labor outcomes of two groups were compared.Results The birth rate of research group was higher than that of control group(P＜0.05).The cesarean section rate and vaginal delivery rate of research group were lower than those of control group(P＜0.05).After attendance,the SASand SDS score of research group were lower than those of controlgroup(P＜0.05).The first labor time and second labor time of research group were shorter than those of controlgroup(P＜0.01).The labor outcomesof research group was better than thatof controlgroup(P＜0.05).Conclusion Doula deliverymode is an excellent caremodel.It has exact effect in improving obstetric care quality.It′sworthy of clinicalwidely used.
2016 Vol. 23 (32): 189-191 [Abstract] ( 138 ) HTML (35 KB)  PDF  (0 KB)  ( 39 )
192 Effect of predictive nursing on lower postoperative com p lications in patientsw ith gallstones
YANG Hong-xia;DENG Cai-miao
Objective To explore the effects of predictive nursing on lower postoperative complications in patients with gallstones.M ethods 150 patientswith gallstones were selected and divided into control group(74 cases)and treatment group（76 cases）according to the order of admission from May to October 2015.Patients in the control group were received general nursing care while patients in treatment group were received predictive nursing care.The postoperative hospital stays,the time gastrointestinal function returned to normal,the rate of complication and patient satisfaction between two groups after operation were compared.Results The postoperative hospital stays of the patients in treatment group was shorter than that of control group;the time gastrointestinal function returned to normal of the patients in treatment group was shorter than that of control group;the rate of complication of the patients in treatment group was lower than thatof control group,the patient satisfaction of the patients in treatment group was higher than that of control group,with the differences were significant(P＜0.05).Conclusion Predictive nursing can shorten the hospital stays and the time gastrointestinal function return to normal.It also can lower the rate of postoperative complications in gallstones patients and enhance patient satisfaction.It isworth generalizing and applying.
2016 Vol. 23 (32): 192-194 [Abstract] ( 125 ) HTML (40 KB)  PDF  (0 KB)  ( 30 )
195 App lication effect of com prehensive nursing in patientsw ith gallstone
WANG Hui;TANG Dan;ZHANG Hong-li
Objective To discuss the application effect of comprehensive nursing in patients with gallstone.M ethods 100 cases with gallstone treated by our hospital from January 2013 to December 2015 were selected,and they were divided into two groups,each group had 50 cases.The control group was given routine nursing,and the observation group was given comprehensive nursing,the life quality,nursing satisfaction degree,complication and mentation between two groups was compared respectively.Results Compared with the control group,the score of life quality in the observation group was significantly higher(P＜0.01),the nursing satisfaction degreewas significantly higher(P＜0.05),and the incidence rate of complication in the observation group was significantly lower(P＜0.05).After intervention,the anxiety and depression score in the observation group were significantly decreased,and were significantly lower than those in the control group (P＜0.01).Conclusion The implementation of comprehensive nursing for patients with gallstone can effectively improve the quality of life,psychological state,reduce complication in patients,but also improve the satisfaction degree of nursing.
2016 Vol. 23 (32): 195-197 [Abstract] ( 127 ) HTML (42 KB)  PDF  (0 KB)  ( 35 )
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