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2022 Vol. 29, No. 2
Published: 2022-01-18
 
 
7 Comparison of five diagnostic models in the diagnosis of non-small cell lung cancer
CHEN Xiaohong ;YANG Yuwei;XU Peng; YANG Wu
Objective To compare the application value of five combined patterns for diagnosing non-small cell lung cancer(NSCLC). Methods A total of 413 NSCLC patients in Mianyang Central Hospital Affiliated to School of Medicine,University of Electronic Science and Technology of China from January 11, 2015 to October 28, 2019 were retrospectively selected as the lung cancer group, a total of 723 patients with benign pulmonary disease and 282 healthy subjects were selected as benign group and healthy control group respectively. Serum carcinoembryonic antigen (CEA), alpha fetoprotein (AFP), carbohydrate antigen 125 (CA125), carbohydrate antigen 199 (CA199) and neuron-specific enolase(NSE) were measured, and were used to develop the models of multiplayer artificial neural network (MPL-ANN), radial basis function artificial neural network (RBF-ANN), decision tree, logistic regression and classical discriminant analysis(CDA). Then the diagnostic efficacy of each model was compared. Results Among the single indicators, CEA had the highest diagnostic value for NSCLC, with the AUC of 0.76 (95%CI: 0.74-0.78), but its specificity was low (64.9%). Of all the diagnostic models for the diagnosis of NSCLC, MPL-ANN model was the optimal with 0.91 (95%CI: 0.89-0.96)of AUC, 75.3% of sensitivity, 91.1% of specificity, as well as 71.7% (76/106) and 94.4% (305/323) of diagnosis accuracy for the lung cancer group and non-lung cancer group, respectively. Conclusion The MPL-ANN model based on tumor markers measurement can be helpful for the diagnosis of NSCLC, which provides a new idea for the differential diagnosis of NSCLC.
2022 Vol. 29 (2): 7-10 [Abstract] ( 50 ) HTML (1 KB)  PDF (670 KB)  ( 29 )
11 Predictive effect of serum interleukin-6 and carcinoembryonic antigen on postoperative recurrence of colorectal cancer
XIONG Yong ;SHEN Rongrong ;LIU Dongyang
Objective To explore the diagnostic value of serum interleukin-6 (IL-6) and carcinoembryonic antigen(CEA) in colorectal cancer and the predictive role of postoperative recurrence. Methods A total of 160 patients with colorectal cancer admitted to the Sixth People′s Hospital of Shanghai Jiaotong University from January 2015 to January 2018 were selected as the colorectal cancer group, a total of 50 patients with benign colon polyps were selected as the benign colon polyp group, and 100 healthy controls during the same period the patient were selected as healthy control group. The serum levels of IL-6 and CEA were observed in the three groups, and the value of serum IL-6 and CEA in the diagnosis of colorectal cancer and the predictive effect of postoperative recurrence were evaluated. Results The positive rate of IL-6 and CEA between the colorectal cancer group Ⅰand the colorectal polyp group was not statistically different (P＞0.05). The positive rates of IL-6 and CEA between the colorectal cancer group Ⅰand the healthy control group in comparison, the difference was not statistically significant (P＞0.05). The positive rates of IL-6 and CEA of stage Ⅱcolorectal cancer were higher than those of colorectal polyp group and healthy control group, the positive rates of IL-6 and CEA of stage Ⅲwere higher than those of colorectal polyp group and healthy control group, and the positive rates of IL-6 and CEA of stage Ⅳwere higher than those of the colorectal polyp group and the healthy control group, and the differences were statistically significant (P＜0.05). IL-6 and CEA predict the AUC of colorectal cancer to be 77.2% and 82.8%. The IL-6 and CEA of the colorectal cancer group after the recurrence group were higher than those of the non-recurrence group, and the differences were statistically significant (P＜0.05). The AUC of IL-6 and CEA for predicting the recurrence of colorectal cancer were 87.3% and 84.1%. Conclusion There are high expressions of IL-6 and CEA in the serum of patients with colorectal cancer. The detection of serum IL-6 is helpful for the diagnosis and prediction of postoperative recurrence in patients with colorectal cancer. It is a supplement to the traditional tumor marker CEA detection.
2022 Vol. 29 (2): 11-14 [Abstract] ( 44 ) HTML (1 KB)  PDF (994 KB)  ( 176 )
15 Clinical effect of repetitive transcranial magnetic stimulation combined with repetitive peripheral magnetic stimulation in treatment of elderly patients with complex regional pain syndrome type Ⅰ
OU Zichang; JIANG Yeqin;CEN Jierong
Objective To investigate the clinical effect of repetitive transcranial magnetic stimulation combined with repetitive peripheral magnetic stimulation (rTMS-rPMS) in the treatment of elderly patients with complex regional pain syndrome type Ⅰ (CRPS Ⅰ). Methods A total of 150 elderly patients diagnosed as CRPS Ⅰin the Third People′s Hospital of Jiangmen City from January 2020 to April 2021 were selected as the research objects, and they were divided into the treatment group and the control group by random number table method, with 75 cases in each group. The treatment group was treated by rTMS combined with rPMS, and the control group was treated with rTMS plus rPMS 0 Hz(false stimulation). The visual analogue scale (VAS) score and clinical treatment effect were compared between the two groups before and after treatment. Results Before the first treatment, there was no statistical significant difference in VAS score between the two groups (P＞0.05). Before the second treatment, VAS score of the treatment group was lower than that of the control group, and the difference was statistically significant (P＜0.05). VAS scores at each time point after two treatments were lower than those before treatment, and the treatment group was lower than that of the control group, the differences were statistically significant (P＜0.05). VAS scores of patients in the treatment group at each time point before and after the second treatment were lower than those of the first treatment, and the differences were statistically significant (P＜0.05). There was no statistically significant difference in VAS score of control group before and 24 h after treatment (P＞0.05). VAS scores at immediately and 72 h after the second treatment were lower than those of the first treatment, and VAS score at 10 d after the second treatment was higher than that of the first treatment,and the differences were statistically significant (P＜0.05). The satisfaction rate of treatment effect in the treatment group was higher than that in the control group, and the difference was statistically significant (P＜0.05). Conclusion The curative effect of rTMS combined with rPMS in the elderly patients with CRPS Ⅰwas more significant than rTMS, and the duration was longer, which was worthy of clinical promotion and application.
2022 Vol. 29 (2): 15-19 [Abstract] ( 46 ) HTML (1 KB)  PDF (548 KB)  ( 58 )
20 Effect of clinical characteristics on patients with gastric cancer developed perigastric soft tissue metastasis and its survival time
ZHAO Hongsheng; PAN Jiyong;YAN Ruifeng; YAN Longchao; CHEN Zhengda;SONG Xiaohai;WANG Mei▲
Objective To explore the effect of clinical characteristics on patients with gastric cancer developed perigastric soft tissue metastasis and its survival time. Methods The clinical data of 412 patients with radical resection of gastric cancer admitted to Dalian Third People′s Hospital from January 2015 to June 2020 were retroreviewed, and divided into the metastasis group (134 cases) and the untransferred group (278 cases) according to whether perigastric soft tissue metastasis was combined. The effect of different clinical characteristics on the development of perigastric soft tissue metastasis in gastric cancer patients, and the impact of different clinical characteristics on the survival of patients with gastric cancer and perigastric soft tissue metastasis were observed. Results The tumor site, tumor size,depth of infiltration, lymph node metastasis, presence of distant metastasis, Bomnann typing, differentiation, serum carcinoem bryonic antigen (CEA) level were related with gastric soft tissue metastasis (P＜0.05). The tumor diameter,organ invasion, lymph node metastasis, combination of distant metastasis, serum CEA level, Borrmann classification and differentiation affected the survival of patients with gastric cancer and gastric soft tissue metastasis (P ＜0.05).Conclusion Soft tissue metastasis of gastric cancer often occurs in patients with ≥5 cm tumor diameter, infiltration depth of T4, with distant metastasis, lymph node metastasis degree＞20%, low or undifferentiated carcinoma, Borrmann infiltration type, serum CEA＞5 g/L, and poor prognosis in patients with perigastric soft tissue metastasis.
2022 Vol. 29 (2): 20-23 [Abstract] ( 41 ) HTML (1 KB)  PDF (553 KB)  ( 25 )
24 Effect of body mass index on hormone level of patients on human chorionic gonadotropin day with in vitro fertilization/intracytoplasmic sperm injection treatment
HUANG Ying; LAO Kaixue; WANG Yanlin▲
Objective To analyze the effect of the different body mass index (BMI) on estradiol (E2), luteinizing hormone (LH) and progesterone (P) values in females who received in vitro fertilization/intracytoplasmic sperm injection(IVF/ICSI) treatment on human chorionic gonadotropin (HCG) day. Methods A total of 1307 cycles of IVF/ICSI conducted in our reproductive center were retrospectively analyzed. Based on the age, female infertility patients were divided into the group of the age ≤35 years old and the group of the age ＞35 years old. Then based on the different BMI, the two groups were further divided into three subgroups: normal weight group (18.5 kg/m2≤BMI＜23 kg/m2),overweight group (23 kg/m2≤BMI＜25 kg/m2) and obese group (BMI≥25 kg/m2). The effect of BMI in different age groups on the hormone level of HCG day were observed. Results There were statistically significant differences in E2 levels of infertile women aged ≤35 years, normal weight group, overweight group and obese group (P＜0.05). The level of E2 in obese group was lower than that in normal group and overrecombinant group, and the difference was statistically significant (P＜0.05). The P level of HCG in the three subgroups was statistically significant (P＜0.05). The P level of obese group was lower than that of normal group and overreorganization group, and the difference was statistically significant (P＜0.05). There was no statistically significant difference in LH on HCG day among the three subgroups (P＞0.05), and there was no statistically significant difference in pregnancy rate among the three subgroups(P＞0.05). There was significant difference in HCG day P level among infertile women aged ＞35 years, normal weight group, overweight group and obese group (P＜0.05). The P level of normal group was higher than that of overweight and obesity group, the difference was statistically significant (P＜0.05). There was no significant difference in E2 and LH levels among the three subgroups on HCG day (P＞0.05), and there was no significant difference in pregnancy rate among the three subgroups (P＞0.05). Correlation analysis showed that BMI was negatively correlated with E2 and P on HCG day(P＜0.05). Partial correlation analysis after age control showed that BMI was negatively correlated with E2 and P on HCG day (P＜0.05). Conclusion For infertile women treated with IVF/ICSI, serum E2 and P levels on HCG day decreased with the increase of BMI, BMI does not affect serum LH level on HCG day, and BMI has not been found to affect pregnancy outcome.
2022 Vol. 29 (2): 24-28 [Abstract] ( 43 ) HTML (1 KB)  PDF (562 KB)  ( 15 )
29 Advances in the study of bone tissue remodeling by Dipsaci Radix
MA Meng;RUAN Qiong;WU Tingyun▲
This article reviews the research on the pharmacological effects, chemical components and bone remodeling effects of Dipsaci Radix. After analyzing and sorting out domestic and foreign papers and literature in recent years, it is believed that the traditional Chinese medicine Dipsaci Radix has a certain effect on bone remodeling. It can interfere with bone metabolism through multiple cellular levels and biological pathways, especially to promote the formation and proliferation of osteoblasts, and accelerate fractures. Healing and repairing and other aspects have a very important impact. The author summarizes the research progress of Dipsaci Radix on bone remodeling in recent years, and provides methods for the research of continuum and further research.
2022 Vol. 29 (2): 29-32转37 [Abstract] ( 49 ) HTML (1 KB)  PDF (511 KB)  ( 134 )
33 Progress in diagnosis and treatment of tuberculosis in pregnancy
HUANG Chunyan
Tuberculosis is a chronic infectious disease caused by Mycobacterium tuberculosis infection. Latent tuberculosis infection during pregnancy has no clinical manifestations, but may develop into active tuberculosis. Most tuberculosis patients have no typical tuberculosis poisoning symptoms, but can lead to adverse pregnancy outcomes.Failure to diagnose and treat in time will have adverse effects on mothers and children, and will reduce the quality of life of these women and their families. Improving the recognition ability of obstetrics and gynecology medical staff plays an important role in identifying whether pregnant women suffer from tuberculosis and whether further treatment is needed after the illness. This article reviews the epidemiology of tuberculosis in pregnancy in recent years, the screening, diagnosis and treatment of latent combined infection during pregnancy and active tuberculosis, and provides reference for clinical practice.
2022 Vol. 29 (2): 33-37 [Abstract] ( 42 ) HTML (1 KB)  PDF (454 KB)  ( 63 )
38

Research of RhaFGF external application promotes healing of refractory skin ulcer in diabetic rats

Research of RhaFGF external application promotes healing of refractory skin ulcer in diabetic rats [J]. 中国当代医药, 2022,29(2): 38-41')" href="#"> SONG Jiuyu;WANG Minhua;LI Haikun;LIAO Baochun; CHEN Xiaobo; Zhu Xiansen;ZENG Xiangtai▲

Objective To investigate the effect of recombinant human acidic fibroblast growth factor (RhaFGF) on healing of diabetic rats with refractory skin ulcers, and to further study the effect and mechanism of RhaFGF on the healing of diabetic rats with refractory skin ulcers. Methods The diabetic rat model of skin ulcer was established. A total of 28 rats were randomly divided into control group and RhaFGF group. The control group was treated with topical saline, and RhaFGF group was treated with topical application of RhaFGF. The wound area was recorded on the seventh day and the fourteenth day, and the new granulation tissue in the skin ulcer area of rats was collected. Superoxide dismutase (SOD), malondialdehyde (MDA), platelet endothelial cell adhesion molecule (CD31), functional antigen Ki-67 (Ki-67) and pathological sections were examined to evaluate the therapeutic effect of RhaFGF in treating diabetic refractory ulcers. Results On day 7 and 14 of treatment, the wound area of the RhaFGF group was smaller than that of the control group, and the difference was statistically significant (P<0.05). MDA content in the RhaFGF group was lower than that in the control group, and the difference was statistically significant (P<0.05). SOD activity in the RhaFGF group was higher than that in the control group, and the difference was statistically significant (P<0.05). The positive expression rate of CD31 in the RhaFGF group was higher than that in the control group, and the difference was statistically significant (P<0.01). The positive expression rate of Ki-67 in the RhaFGF group was higher than that in the control group, and the difference was statistically significant (P<0.01). Histopathological examination showed that the number of new capillaries, fibroblasts and collagen expression increased in RhaFGF group compared with before treatment. Conclusion RhaFGF promotes oxidative stress of diabetic refractory ulcers, increases the production of capillaries and fibroblasts in ulcerated tissues, and significantly increases the level of epithelial regeneration, thereby demonstrating the repair effect on diabetic ulcers.
2022 Vol. 29 (2): 38-41 [Abstract] ( 40 ) HTML (1 KB)  PDF (892 KB)  ( 71 )
42 Effect of tumstatin 19 peptide on proliferation and apoptosis of SK-Hep-1 cells
WANG Shun; LIU Taoyuan ;LI Ang ;YI Tonghui ;PAN Hongming ;LI Shuyan▲
Objective To study the effect of tumstatin 19 peptide proliferation and apoptosis of hepatoma SK-Hep-1 cells. Methods CCK-8 was used to detect the effect of 19 peptide （0, 50, 100, 150, 200, 250 μg/ml） on the proliferation of SK-Hep-1 cells. DAPI staining was used to detect the morphological changes of SK-Hep-1 cell apoptosis,and flow cytometry was used to detect the effect of 19 peptide on SK-Hep-1 cell apoptosis. Results Sk-hep-1 cells were treated with 0, 50, 100, 150, 200, 250 μg/ml 19 peptide, after 24 h, the survival rates were (100.00±1.80)%, (95.64±1.92)%, (82.18±1.67)%, (68.43±1.39)%, (46.74±1.35)%, (42.49±1.85)%, respectively. After 48 h treatment, the cell survival rate was (100.00±1.80)%, (87.27±1.96)%, (66.32±1.74)%, (58.78±1.94)%, (40.40±1.44)%, (22.15±1.51)%, respectively. When 19 peptide was 0 μg/ml, most of SK-HEP-1 cells were stained uniformly and blue, and apoptosis did not occur. Compared with 0 μg/ml, some cells showed bright blue after treated with 50, 100, 150, 200 and 250 μg/ml 19 peptide for 24 h, and the nuclei showed concentration, rupture, fragmentary dense and dense staining or cap-like apoptotic morphology. The apoptosis rate increased with the increase of 19 peptide concentration. Conclusion 19 peptide can effectively inhibit the proliferation of SK-Hep-1 cells and induce the apoptosis, which provides theoretical guidance for the research and clinical treatment of new anti hepatoma drugs.
2022 Vol. 29 (2): 42-44 [Abstract] ( 36 ) HTML (1 KB)  PDF (1037 KB)  ( 25 )
45 Effect of Beraprost combined with Pitavastatin in the treatment of chronic obstructive pulmonary disease-related pulmonary hypertension
LI Lihua; CHEN Yuanhui; LI Ying
Objective To study the effect of Beraprost and Pitavastatin in the treatment of chronic obstructive pulmonary disease (COPD) -related pulmonary hypertension. Methods A total of 100 COPD-related pulmonary hypertension patients admitted to the First Hospital of Nanchang from December 2019 to December 2020 were selected as the research subjects. They were divided into an observation group and a control group according to the principle of random drawing, with 50 cases in each group. Patients in the observation group were treated with Beraprost combined with Pitavastatin, and patients in the control group were treated with Beraprost. The total effectiveness rate, lung function indexes, and inflammatory factors of the two groups of patients were compared. Results The total effectiveness rate of treatment in the observation group was higher than that in the control group, the difference was statistically significant(P＜0.05). The forced expiratory volume in the first second (FEV1), the forced expiratory volume in the first second/forced vital capacity (FEV1/FVC) and percentage of predicted value of the FEV1 (FEV1%) of the observation group were higher than those of the control group, the differences were statistically significant (P＜0.05). The indexes of blood neutrophils,interleukin-8 (IL-8) and tumor necrosis factor-α (TNF-α) in patients with COPD-related pulmonary hypertension in the observation group were lower than those in the control group, the differences were statistically significant (P＜0.05).Conclusion Compared with Beraprost monotherapy, the combination of Beraprost and Pitavastatin has a better effect in the treatment of COPD-related pulmonary hypertension, which can improve the patients′ lung function indicators.
2022 Vol. 29 (2): 45-47转51 [Abstract] ( 47 ) HTML (1 KB)  PDF (556 KB)  ( 83 )
48 Effect of Tanreqing on procalcitonin and T lymphocyte subsets in patients with acute exacerbation of chronic obstructive pulmonary disease
FAN Lizhen;XIONG Jiangqin; YU Jia
Objective To investigate the effect of Tanreqing on procalcitonin (PCT) and T lymphocyte subsets in patients with acute exacerbation of chronic obstructive pulmonary disease (COPD). Methods A total of 100 patients with acute exacerbation of COPD who were treated in the Department of Internal Medicine, Jiangxi Chest Hospital from January 2017 to December 2019 were selected as the research subjects, they were divided into an observation group and a control group by random number table method, 50 cases in each group. The patients in the control group received conventional treatments such as oxygen inhalation, bronchodilators and anti-infection, patients in the observation group were treated with Tanreqing Injection on the basis of the control group. Both groups continued treatment for one week.The immune function, peripheral blood PCT and C-reactive protein (CRP) levels were compared between the two groups before and after treatment. Results There were no statistically significances in the levels of PCT, CRP, CD4+/CD8+, CD4+and CD8+ in the peripheral blood of the patients in the two groups before treatment (P＞0.05). The levels of CD4+/CD8+ and CD4+ in the peripheral blood of the patients in the two groups after treatment were higher than those before, the levels of CD4+/CD8+ and CD4+ in the peripheral blood of the patients in the observation group were higher than those of the control group, and the differences were statistically significant (P＜0.05). The levels of CD8+, PCT and CRP levels in the peripheral blood of the patients in the two groups after treatment were lower than those before treatment, the levels of CD8+, PCT and CRP levels in the peripheral blood of the patients in the observation group were lower than those of the control group, and the differences were statistically significant (P＜0.05). Conclusion Tanreqing can improve the immune function of patients with acute exacerbation of COPD, reduce the inflammatory response, and relieve patients′ symptoms.
2022 Vol. 29 (2): 48-51 [Abstract] ( 40 ) HTML (1 KB)  PDF (554 KB)  ( 35 )
52 Clinical application of Butylphthalide Soft Capsules combined with Edaravone in treatment of cerebral infarction
AN Na
Objective To investigate the clinical application effect of Butylphthalide Soft Capsules combined with Edaravone in treatment of cerebral infarction. Methods A total of 100 patients with cerebral infarction who were treated in Anshan Tumor Hospital from April 2018 to June 2020 were selected as the research objects. According to the computer random assignment method, the patients were assigned and divided into the control group (50 patients) and the experimental group (50 patients). The control group was treated with Edaravone, and the experimental group was treated with Butylphthalide Soft Capsules combined with Edaravone. The clinical efficacy, total incidence of adverse reactions,Barthel index and quality of life of the two groups were compared after treatment. Results The total effective rate of treatment of the experimental group was higher than that of the control group, and the difference was statistically significant (P＜0.05). The Barthel index of the experimental group was higher than that of the control group, with statistical significance (P＜0.05). The total incidence of adverse reactions in the experimental group was lower than that in the control group, the difference was statistically significant (P＜0.05). The scores of psychological function, material function, social function and physical function in the experimental group were higher than those in the control group, and the differences were statistically significant (P＜0.05). Conclusion The clinical efficacy of Butylphthalide Soft Capsules combined with Edaravone in the treatment of cerebral infarction is significant, which can effectively improve the quality of life of patients and reduce their adverse reactions.
2022 Vol. 29 (2): 52-54 [Abstract] ( 48 ) HTML (1 KB)  PDF (534 KB)  ( 54 )
55 Study on the influencing factors of type 2 diabetic complicated with diabetic kidney disease microalbuminuria
CHU Dongmei ;GUO Jiayu ;XIAO Luwei ;LENG Juanjuan ;LI Jianzhi▲
Objective To explore the influencing factors of type 2 diabetes mellitus (T2DM) complicated with diabetic kidney disease (DKD) microalbuminuria. Methods A total of 308 T2DM patients from two tertiary A hospitals in Hengyang City from August 2020 to April 2021 as the research objects. Patients were divided into groups according to the occurrence of microalbuminuria, urinary albumin excretion rate (UAER) of 30-300 mg/24 h was included in the DKD group, UAER＜30 mg/24 h was included in the non-DKD group. The influencing factors of DKD in T2DM patients were analyzed by binary logistic regression. Results Among 308 T2DM patients in this study, 136 (44.16%) were DKD microalbuminuria patients and 172 (55.84%) were non-DKD microalbuminuria patients. Univariate analysis showed that age, duration of diabetes, systolic blood pressure, diastolic blood pressure, low density lipoprotein cholesterol (LDL-C),fasting blood glucose (FPG), glycosylated hemoglobin (HbA1c), proportion of history of hypertension and proportion of abdominal obesity in DKD group were higher than those in non-DKD group, self-efficacy score and health promotion lifestyle score in DKD group were lower than those of non-DKD group, and the differences were statistically significant(P＜0.05). The results of binary logistic regression analysis showed that the course of diabetes mellitus (β=0.055, OR=1.057, 95%CI=1.007-1.109), systolic blood pressure (β=0.039, OR=1.040, 95%CI=1.016-1.064), LDL-C (β=0.333,OR=1.395, 95%CI=1.017-1.914), abdominal obesity(β=0.596, OR=1.815, 95%CI=1.039-3.171), HbA1c(β=0.182, OR=1.199, 95%CI=1.071-1.344) were risk factors for DKD microalbuminuria in T2DM patients (P＜0.05), health promotion lifestyle score (β=-0.018, OR=0.983, 95%CI=0.967-0.998), self-efficacy score (β=-0.029, OR=0.972, 95%CI=0.948-0.996) was protective factors for DKD microalbuminuria in T2DM patients (P＜0.05). Conclusion With the prolonged duration of the course of diabetes mellitus and poor glycaemic control, T2DM patients are prone to kidney disease. Nurses should pay attention to improving the self-efficacy of the patients, advocating a health-promoting lifestyle, which can help prevent or delay the occurrence of microalbuminuria of diabetic kidney disease.
2022 Vol. 29 (2): 55-59转64 [Abstract] ( 46 ) HTML (1 KB)  PDF (631 KB)  ( 16 )
60 Effect of Mesalamine combined with Tin Powder enema in the treatment of ulcerative colitis and its influence on the immune function and cytokines of patients
CAI Yi ;HE Mingjie;LUO Peipei
Objective To explore the effect of Mesalazine combined with Tin Powder enema in the treatment of ulcerative colitis (UC) and its influence on the immune function and cytokines of patients. Methods A total of 76 patients with UC who were diagnosed and treated in Wujin Hospital Affiliated to Jiangsu University from January 2018 to January 2021 were selected as the research subjects. According to the random number table method, they were divided into a control group and a study group, with 38 cases in each group. The control group was treated with Mesalazine, and the study group was treated with Tin Powder enema on the basis of the control group. The clinical efficacy, helper T cells (Th17) and regulatory T cells (Treg), T cell subsets (CD4+, CD8+, CD4+/CD8+), natural killer cell (NK) levels, immunoglobulin (Ig) A, IgG, IgM levels, serum interleukin (IL)-10, IL-18, IL-6, IL-4, and tumor necrosis factor-α(TNF-α) and the occurrence of adverse reactions were compared between the two groups. Results The total effective rate of study group was 92.11%, which was higher than that of control group (68.42%), and the difference was statistically significant (P＜0.05). The expression level of Th17 in the study group after treatment was lower than that in the control group, and the difference was statistically significant (P＜0.05). The expression level of Treg in the study group after treatment was higher than that in the control group, and the difference was statistically significant (P＜0.05). After treatment, CD4+, CD4+/CD8+ and NK levels in the study group were higher than those in the control group, while CD8+level in the study group was lower than that in the control group, the differences were statistically significant (P＜0.05).The levels of IgA, IgG and IgM in the study group after treatment were lower than those in the control group, and the differences were statistically significant (P＜0.05). The levels of IL-10 and IL-4 in the study group after treatment were higher than those in the control group, with statistical significances (P＜0.05). The levels of IL-18, IL-6 and TNFα in the study group after treatment were lower than those in the control group, the differences were statistically significant (P＜0.05). There was no significant difference in the total incidence of adverse reactions between the two groups(P＞0.05). Conclusion Mesalamine combined with Tin Powder enema can enhance the clinical treatment effect in patients with UC, improve the immune function, reduce inflammation, and have varying degrees of impact on immune indicators and cytokines, and it is safer.
2022 Vol. 29 (2): 60-64 [Abstract] ( 56 ) HTML (1 KB)  PDF (592 KB)  ( 12 )
65 Application of Vancomycin bone cement in the postoperative infection in patients with open calcaneal fractures
CHEN Zhongliang ;LU Jianxin ;LI Da; CUI Jun▲
Objective To explore the efficacy of Vancomycin bone cement in the treatment of postoperative infections in patients with open calcaneal fractures. Methods A total of 46 patients with open calcaneal fractures who were admitted to the Department of Orthopedics and Chiropodist of the Affiliated Central Hospital of Shenyang Medical College from January 2016 to December 2020 were selected as the research objects. They were divided into the control group and the observation group by random number table method, with 23 cases in each group. The control group received routine treatment, complete debridement, removal of necrotic tissue and continuous irrigation with antibiotics. On the basis of the control group, Vancomycin bone cement was selected to fill the bone defect in the observation group according to the drug sensitivity test results.The total effective rate,times of dressing change,wound healing time,infection control time,length of hospital stay, serum levels of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), C-reactive protein (CRP),neutrophils,white blood cell count and erythrocyte sedimentation rate were compared between the two groups. Results The total effective rate of the observation group was higher than that of the control group, and the difference was statistically significant (P＜0.05). The frequency of dressing change in the observation group was less than that in the control group,and the difference was statistically significant (P＜0.01). The wound healing time, infection control time and hospital stay time in the observation group were shorter than those in the control group, and the differences were statistically significant (P＜0.01). After treatment, TNF-α, IL-6, neutrophil, white blood cell count, CRP and erythrocyte sedimentation rate in the observation group were lower than those in the control group, and the differences were statistically significant (P＜0.01). Conclusion Vancomycin bone cement has a good effect on controlling infection and inhibiting inflammation in patients with postoperative infection of open calcaneal fractures, and the treatment effect is good.
2022 Vol. 29 (2): 65-68 [Abstract] ( 43 ) HTML (1 KB)  PDF (543 KB)  ( 77 )
69 Application effect of modified Stoppa approach surgery in patients with pelvic acetabular fracture
WU Chucheng;PAN Jiarong;HU Xiaoying;CHEN Kaining
Objective To explore the application effect of modified Stoppa approach surgery in patients with pelvic acetabular fracture. Methods A total of 50 patients with pelvic and acetabular fractures in Puning People′s Hospital of Guangdong Province from March 2015 to March 2020 were selected as the research objects, and divided into observation group(25 cases)and control group(25 cases)according to the random number table method.The control group was treated by ilioinguinal approach, and the observation group was treated by Stoppa approach. The postoperative effect, total incidence of complications,Harris hip joint function score were compared between the two groups. Results The operation time and postoperative wound healing time of the observation group were shorter than those of the control group, and the amount of intraoperative bleeding was less than that of the control group, with statistically significant differences(P＜0.05). The total incidence of complications in the observation group (8.00%) was lower than that in the control group(24.00%), with statistically significant difference (P＜0.05). The Harris hip joint function score of the observation group was higher than that of the control group, with statistically significant difference (P＜0.05). Conclusion The modified Stoppa approach plays a positive role in the clinical treatment of patients with acetabular and pelvic fractures. It can improve the effect of surgical treatment, reduce the incidence of complications and improve the function of hip joint.
2022 Vol. 29 (2): 69-71转75 [Abstract] ( 41 ) HTML (1 KB)  PDF (484 KB)  ( 44 )
72 Application effect of acupuncture and massage combined with lumbar core muscle strength training on patients with lumbar intervertebral disc herniation
ZHAO Jianfeng; WU Feng ;SHI Pengxu; GUO Qingsheng▲
Objective To investigate the effect of acupuncture and massage combined with lumbar core muscle strength training on the Oswestry disability index (ODI) score, trunk muscle strength and short-form of McGill pain questionnaire(MPQ) score in patients with lumbar intervertebral disc herniation. Methods A total of 136 patients with lumbar intervertebral disc herniation who were treated in the Department of Orthopedics of Liaoning Provincial People′s Hospital from January 2017 to August 2019 were selected as the research objects, and they were divided into the study group(n=68)and the control group(n=68)by the random number table method. Patients in the control group were treated with lumbar core muscle strength training, and patients in the research group were treated with acupuncture and massage on the basis of the control group. The ODI scores, trunk muscle strength, MPQ scores and total effective rates were compared between the two groups. Results After treatment, the ODI scores of the two groups were lower than those before treatment, the differences were statistically significant (P＜0.05), and the ODI score of study group was lower than that in the control group,the difference was statistically significant(P＜0.05).After treatment,the trunk muscle strength levels of patients in the two groups were better than those before treatment, and the differences were statistically significant(P＜0.05), the trunk muscle strength level of patients in the study group was better than that of patients in the control group, and the difference was statistically significant (P＜0.05). After treatment, the scores of various items on MPQ in the two groups were lower than those before treatment,and the differences were statistically significant (P＜0.05),the scores of various items on MPQ in the study group were lower than those in the control group, and the differences were statistically significant (P＜0.05). After treatment, the total effective rate of the study group was higher than that of the control group, and the difference was statistically significant (P＜0.05). Conclusion Compared with lumbar core muscle strength training alone, acupuncture and massage combined with lumbar core muscle strength training has more advantages in reducing the ODI score, improving trunk muscle strength, relieving pain and increasing the curative effect in patients with lumbar intervertebral disc herniation.
2022 Vol. 29 (2): 72-75 [Abstract] ( 44 ) HTML (1 KB)  PDF (464 KB)  ( 12 )
76 Application of bronchoscopy narrowband imaging technique in the clinical diagnosis of bronchogenic carcinoma
LI Xunji;SHAO Yu; CAO Kaixi;WANG Lan
Objective To explore the clinical application of bronchoscopy narrowband imaging technique in the diagnosis of patients with bronchogenic carcinoma. Methods A total of 110 patients with suspected central lung cancer complicated with incomplete airway obstruction admitted to the Department of Respiratory Medicine, Third People′s Hospital of Jiujiang City were retrospectively selected as the research subjects between January 2020 and February 2021. All patients were examined by bronchoscopy and narrowband imaging analysis, and biopsy was taken as the gold standard to compare the diagnostic efficacy of the two examination methods on bronchogenic carcinoma. Results Among 110 suspected lung cancer patients, 87 cases of central lung cancer were diagnosed by pathological biopsy. The sensitivity,specificity, accuracy, positive predictive value, negative predictive value and Kappa value of narrowband imaging were 91.95%, 86.96%, 90.91%, 96.39%, 74.07%, and 0.742, which were in good consistency with the gold standard. Among 87 cases of patients with lung cancer, narrowband imaging showed there were 28 cases of vascular cord distortion(mainly squamous cell carcinoma [21.84%]), 27 cases of vascular punctate distribution (mainly adenocarcinoma[20.69%]) and 32 cases of sudden vascular interruption (mainly squamous cell carcinoma [22.99%]). Conclusion Bronchoscopy narrowband imaging endoscopy has a good inspection efficiency in the examination of bronchogenic carcinoma. Compared with light microscopy, it has higher sensitivity and specificity, and can effectively locate the diseased area and examine its tissue and blood vessels to improve the clinical diagnostic efficiency.
2022 Vol. 29 (2): 76-78 [Abstract] ( 50 ) HTML (1 KB)  PDF (526 KB)  ( 64 )
79 Clinical effect of Ruxolitinib in the treatment of JAK2V617F-positive myeloproliferative neoplasms
ZOU Min
Objective To explore the clinical effect of Ruxolitinib in the treatment of JAK2V617F-positive myeloproliterative neoplasms (MPN). Methods A total of 60 JAK2V617F positive MPN patients admitted to Ganzhou People′s Hospital from July 2017 to July 2019 were selected as the study subjects, and they were divided into observation group and control group by random number table method, with 30 patients in each group. The control group was treated with oral Hydroxycarbamide Tablets, while observation group was treated with oral Ruxolitinib. Total MPN-10 score,myelofibrosis (MF) grading assessment, spleen diameter, relative expression levels of JAK2V617F gene in bone marrow were compared between two groups before and after treatment, and the occurrence of adverse reactions between two groups during treatment was recorded. Results After treatment, the MPN-10 and MF scores of the observation group were lower than those of the control group, and the spleen diameter of the observation group was shorter than that of the control group,the differences were statistically significant (P＜0.05).The relative expression level of JAK2V617F gene in the observation group were lower than those in the control group after 6 months and 1 year of treatment, the differences were statistically significant (P＜0.05). There was no significant difference in the total incidence of adverse reactions between the two groups (P＞0.05). Conclusion Ruxolitinib can significantly reduce expression level of JAK2V617F gene in patients with JAK2V617F-positive MPN, reverse myelofibrosis level, and improve clinical curative effect.
2022 Vol. 29 (2): 79-81 [Abstract] ( 47 ) HTML (1 KB)  PDF (538 KB)  ( 175 )
82 Efficacy and safety of Carrelizumab combined with Arotinib in the treatment of small cell lung cancer
LI Yanbing ;SHI Xin ;CAI Lingyu ;ZUO Hongbo ;WANG Zhi
Objective To observe the efficacy and safety of Carrelizumab combined with Arotinib in the treatment of small cell lung cancer (SCLC). Methods A total of 76 patients with SCLC who were admitted to Jiujiang First People′s Hospital from November 2017 to October 2019 were selected as research objects. They were divided into control group and observation group according to random number table method, with 38 cases in each group. The control group was treated with Arotinib, and the observation group was treated with Carrelizumab combined with Arotinib, with a course of treatment every 3 weeks and 6 consecutive courses of treatment. The clinical efficacy, quality of life, progression-free survival (PFS), overall survival (OS) and adverse reactions were compared between the two groups. Results There was no statistical significance in objective response rate (ORR) and disease control rate (DCR) between the two groups (P＞0.05). After 2, 4 and 6 courses of treatment, the Karnofsky score (KPS) of the observation group was higher than that of the control group, and the OS and PFS of the observation group were longer than those of the control group, the differences were statistically significant (P＜0.05). There was no statistical significance between the two groups in the total incidence of adverse reactions (P＞0.05). Conclusion Patients with SCLC treated with Carrelizumab combined with Arotinib have better effect, which is conducive to improving the quality of life, prolonging the survival time of patients and reducing toxic and side effects.
2022 Vol. 29 (2): 82-84转88 [Abstract] ( 91 ) HTML (1 KB)  PDF (898 KB)  ( 47 )
85 Effect of Olanzapine on preventing vomiting in patients with breast cancer treated with Pirarubicin combined with Cyclophosphamide chemotherapy
HAN Yongqing ;FU Feng ;HUANG Kairong▲
Objective To explore the effect of Olanzapine in the prevention of vomiting in breast cancer patients treated with Pirarubicin combined with Cyclophosphamide (AC) chemotherapy. Methods A total of 50 breast cancer patients who received AC chemotherapy in Shangrao People′s Hospital from January 2020 to March 2021 were selected as research subjects. They were divided into control group and observation group according to random number table method,with 25 cases in each group. The control group was treated with Ondansetron combined with Dexamethasone for prevention, the observation group was treated with Olanzapine for prevention on the basis of the control group. The acute, delayed complete remission (CR) rates of nausea and vomiting in the first cycle of chemotherapy and expected CR rate of nausea and vomiting in the second cycle of chemotherapy, the total incidence of extrapyramidal reaction after one cycle were compared between the two groups. Results There was no statistical significance in the rate of acute CR in the first cycle between the two groups (P＞0.05). There was no statistical significance in the rate of acute CR in the first cycle,delayed CR in the first cycle and expected CR in the second cycle in the observation group (P＞0.05). There was no statistical significance in the rate of delayed CR in the first cycle and expected CR in the second cycle in the observation group (P＞0.05). The rates of delayed CR in the first cycle and expected CR in the second cycle in the observation group were higher than those in the control group, the differences were statistically significant (P＜0.05). The delayed CR rate of the first cycle and the expected CR rate of the second cycle in the control group were lower than the acute CR rate of the first cycle, the differences were statistically significant (P＜0.05). There was no statistical significance between the delayed CR rate of the first cycle and the expected CR rate of the second cycle in the control group (P>0.05). There was no statistical significance in the total incidence of extrapyramidal reaction between the two groups (P>0.05). Conclusion Olanzapine is effective in preventing delayed and expected nausea and vomiting caused by AC chemotherapy in breast cancer patients, and does not increase the total incidence of extrapyramidal reactions.
2022 Vol. 29 (2): 85-88 [Abstract] ( 58 ) HTML (1 KB)  PDF (537 KB)  ( 10 )
89 Effect of laparoscopic radical resection of cervical cancer in the treatment of early cervical cancer
ZHANG Dan; ZHANG Yuyang;SUN Xiuyun
Objective To investigate the effect of laparoscopic radical resection of cervical cancer in the treatment of early cervical cancer. Methods A total of 110 patients with early cervical cancer admitted to Fukuang General Hospital of Liaoning Health Industry Group from October 2019 to March 2021 were selected as the research subjects. According to random number table method, they were divided into experimental group and control group, with 55 cases in each group. Patients in the experimental group were treated with laparoscopic radical resection of cervical cancer, patients in the control group were treated with open radical resection of cervical cancer. The total incidence of postoperative complications, postoperative recovery time, hospital stay, exhaust time, and surgical satisfaction of the two groups were compared. Results The total incidence of postoperative complications of the experimental group were lower than that of the control group, the difference was statistically significant (P＜0.05). The postoperative recovery of diet and exhaust time in the experimental group were earlier than those of the control group, the hospital stay was shorter than that of the control group, the differences were statistically significant (P＜0.05). The surgical satisfaction of the experimental group was higher than that of the control group, the difference was statistically significant (P＜0.05). Conclusion For the clinical treatment of patients with early cervical cancer, the use of laparoscopic radical resection of cervical cancer can effectively reduce the complications and improve the patient′s satisfaction on the surgery. It is worthy of clinical publicity.
2022 Vol. 29 (2): 89-91 [Abstract] ( 61 ) HTML (1 KB)  PDF (527 KB)  ( 18 )
92 Clinical study of anterior inversion position combined with lateral release position in the correction of breech presentation
LIU Jun ;LI Yuefen; HU Yan ;ZENG Hong; WANG Shan ;YANG Suqin ;WANG Yu
Objective To explore the clinical effect of anterior inversion position combined with lateral release position in the correction of breech presentation. Methods A total of 120 pregnant women with breech presentation indicated by ultrasound who underwent regular antenatal examination in Pingxiang Maternal and Child Health Hospital were enrolled from April 2019 to April 2020. According to random number table method, they were divided into the observation group(n=60) and the control group (n=60). The observation group was given anterior inversion position combined with lateral release position for intervention, the control group was given routine knee-thorax lying position for intervention. The success rate of correction, normal delivery rate, spending time of breech position correction, intervention comfort and stage of labor between the two groups were compared. Results After intervention, the success rate of correction and the normal delivery rate in the observation group were higher than those in the control group, spending time of breech position correction in the observation group was shorter than that in the control group, intervention comfort in the observation group was higher than that in the control group, and stage of labor in the observation group was shorter than that in the control group, the differences were statistically significant (P＜0.05). Conclusion The anterior inversion position combined with lateral release position for intervention can effectively correct breech presentation, increase normal delivery rate, shorten spending time of breech position correction, improve comfort and shorten stage of labor.
2022 Vol. 29 (2): 92-94 [Abstract] ( 43 ) HTML (1 KB)  PDF (650 KB)  ( 32 )
95 Application effect of restrictive fluid resuscitation in emergency treatment of obstetric massive hemorrhage
CHEN Ping;XIAO Xiang;ZHANG Jie;YU Yan
Objective To explore the application effect of restrictive fluid resuscitation in the emergency treatment of obstetric hemorrhage. Methods From May 2018 to December 2020, 200 patients with obstetric hemorrhage admitted to Shenzhen Bao′an District Maternal and Child Health Hospital were selected as the research objects, and divided into observation group (100 cases) and control group (100 cases) by random lottery method. The observation group was treated with restrictive fluid resuscitation, and the control group was treated with traditional infusion resuscitation. The fluid input volume, bleeding volume and blood transfusion volume, hemodynamic indicators, coagulation function indicators, and treatment effect were compared between the two groups. Results After 2 hours of treatment, the amount of fluid input, blood loss and blood transfusion in the observation group were less than those in the control group, and the differences were statistically significant (P＜0.05). There were no statistically significant differences in mean arterial pressure (MAP), central venous pressure (CVP), hematocrit (HCT), and heart rate (HR) between the two groups before treatment (P>0.05). After treatment, MAP, CVP and HCT of the two groups were higher than those before treatment,and HR was lower than that before treatment, and MAP, CVP and HCT of observation group were higher than those of control group, and HR was lower than that of control group, the differences were statistically significant (P＜0.05). There were no significant differences in prothrombin time (PT), partial thrombin time (APTT), thrombin time (TT) and fibrinogen (FIB) between the two groups before treatment (P>0.05). After treatment, PT, APTT and TT in the two groups were lower than those before treatment, while FIB was higher than that before treatment, and PT, APTT and TT in the observation group were lower than those of control group, while FIB was higher than that of control group, the differences were statistically significant (P＜0.05). The total effective rate of observation group was higher than that of control group,the difference was statistically significant (P＜0.05). Conclusion Restricted fluid resuscitation is very effective in emergency treatment of obstetric massive hemorrhage, which can effectively improve fluid input, blood loss and transfusion volume, hemodynamic indexes, coagulation function indexes and therapeutic effect.
2022 Vol. 29 (2): 95-981转02 [Abstract] ( 41 ) HTML (1 KB)  PDF (649 KB)  ( 115 )
99 Effect of vaginal uterine artery descending branch ligation combined with Carboprost Tromethamine Injection in the treatment of postpartum hemorrhage
LI Xiafang ;ZENG Yanzhen ;XU Minjuan ;ZENG min
Objective To explore the effect of vaginal uterine artery descending branch ligation combined with Carboprost Tromethamine Injection (Hemabate) in the treatment of postpartum hemorrhage. Methods A total of 40 patients with postpartum hemorrhage who gave birth in Ganzhou People′s Hospital from January 2019 to March 2020 were selected as the research objects, and they were divided into the control group and the observation group according to random number table method, with 20 cases in each group. Patients in the control group were treated with Oxytocin and Carboprost Tromethamine Injection, while patients in the observation group were treated with Carboprost Tromethamine Injection and vaginal uterine artery descending branch ligation. The postpartum hemorrhage volume,postpartum recovery index and incidence of adverse events were compared between the two groups. Results The postpartum hemorrhage volume at 2 and 24 h after delivery of the observation group were lower than those of the control group, and the differences were statistically significant (P＜0.05). There were no significant differences in the postpartum lochia time, postpartum menstrual volume and postpartum menstrual cycle between the two groups (P＞0.05).The hemostasis time and hospitalization time of the observation group were shorter than those of the control group, the differences were statistically significant (P＜0.05). The hysterectomy rate (5.00%) and the incidence rate of puerperal disease (10.00%) of the observation group were lower than those of the control group (30.00%, 40.00%), and the differences were statistically significant (P＜0.05). Conclusion Transvaginal uterine artery descending branch ligation combined with Carboprost Tromethamine Injection is effective in the treatment of postpartum hemorrhage, which is worthy of promotion.
2022 Vol. 29 (2): 99-102 [Abstract] ( 43 ) HTML (1 KB)  PDF (658 KB)  ( 90 )
103 Effect of single balloon combined with Phloroglucinol on cervical ripening and maternal and infant outcomes in late pregnancy women
LI Liang′er ;WU Guan ;JIANG Jun
Objective To explore the effect of single balloon combined with Phloroglucinol on cervical ripening and maternal and infant outcomes of late pregnant women. Methods A retrospective selection of 84 late-pregnancy women admitted to Yangchun Maternity and Child Health Hospital from January 2020 to December 2020 was selected as the research object. According to the different intervention methods, they were divided into observation group and control group, with 42 cases in each group. The control group were induced labor by single balloon, while the observation group were induced labor by single balloon combined with Phloroglucinol. The cervical maturity, labor process and maternal and infant outcomes of the two groups were compared, and the relevant data were statistically analyzed. Results There was no significant difference in Bishop score between the two groups before intervention (P＞0.05). The Bishop score of the two groups after intervention were higher than those before intervention, and the Bishop score of the observation group was higher than that in the control group after intervention, and the differences were statistically significant. There was no significant difference in the third stage of labor between the experimental group and the control group (P＞0.05). The postpartum hemorrhage of the experimental group was lower than that of the control group, the difference was statistically significant (P＜0.05). There were no significant differences in neonatal weight, 5 min Apgar score, 15 min neurological and adaptive capacity score (NACS) and 24 h NACS between the experimental group and the control group (P＞0.05). Conclusion The single balloon combined with Phloroglucinol induction of labor for late pregnant women can improve the cervical maturity of women, shorten the labor process of patients, and improve the maternal and infant outcomes, which has a clear clinical effect, so it is recommended to promote the application.
2022 Vol. 29 (2): 103-105 [Abstract] ( 39 ) HTML (1 KB)  PDF (619 KB)  ( 25 )
106 Application effect of remote electronic fetal heart rate monitoring in pregnant women in the third trimester
HUANG Ya ;PENG Jing;LI Yanru ;LUO Xianmei
Objective To explore the effect of remote electronic fetal heart rate monitoring in pregnant women in the third trimester of pregnancy. Methods A total of 100 pregnant women in the third trimester of pregnancy admitted to the First Hospital of Kunming from January 2020 to June 2020 were selected. They were divided into a control group(50 cases) and an observation group (50 cases) according to the random number table method. The control group used traditional bedside electronic fetal monitoring, and the observation group used remote electronic fetal monitoring (EFM).The abnormal results of fetal heart rate monitoring (abnormal amniotic fluid, abnormal fetal movement, and abnormal umbilical cord), pregnancy outcomes, delivery methods and overall maternal health scores of the two groups were compared. Results The incidence rates of abnormal amniotic fluid, fetal movement and umbilical cord in the observation group were lower than those in the control group, and the differences were statistically significant (P＜0.05).There were no statistical differences in the rates of fetal distress and puerperal infection between the two groups (P＞0.05). The rates of premature infants and cesarean section in the observation group were lower than those of the control group, and the rate of natural delivery was higher than that of the control group, and the differences were statistically significant (P＜0.05). Before intervention, there was no statistically significant difference in the overall health scores of the two groups (P＞0.05). After intervention, the overall health scores of the two groups were higher than those before intervention, and the overall health scores of the observation group were higher than those in the control group, the differences were statistically significant (P ＜0.05). Conclusion Application of remote electronic fetal heart rate monitoring to pregnant women in the third trimester can reduce the occurrence of cesarean section and premature infants by increasing the ratio of full-term delivery and natural delivery, thereby improving the quality of life of pregnant women in the third trimester.
2022 Vol. 29 (2): 106-108 [Abstract] ( 40 ) HTML (1 KB)  PDF (620 KB)  ( 46 )
109 Effect of blastocyst culture density on embryo development potential of in vitro fertilization-embryo transfer technology
CHEN Yankun; XIAN Zhuojie;CHI Linsheng; HUANG Jianzhou ;MA Wenmin
Objective To study the effect of blastocyst culture density on embryo development potential of in vitro fertilization embryo transfer (IVF-ET). Methods A total of 235 patients with IVF-ET Foshan Maternal and Child Health Hospital from January 2019 to December 2019 were selected as subjects, and the 1181 successfully transplanted cleavage embryos were divided into four groups according to the difference in blastocyst culture density, individual cultures were grown in group A, 2 to 3 in group B, 4 to 5 in group C, and more than 6 in group D, there were 269 blastocysts in group A, 298 blastocysts in group B, 304 blastocysts in group C, and 310 blastocysts in group D. Blastocym formation rates, available blastocyst rates, high quality blastocyst level differences, blastocyst implantation rates and clinical pregnancy rates in the 4 groups were compared. Results The blastocyst formation rate, usable blastocyst rate, and highquality blastocyst rate in group C were higher than those in groups A, B, and D, and the differences were statistically significant (P＜0.05). Blastocysts accounted for stages 4 to 6 in group C was higher than that of groups A, B, and D, the differences were statistically significant (P＜0.008). Four groups of embryos form a total of 778 embryo sacs, the blastocyst implantation rate and clinical pregnancy rate of blastocyst formation in group C were higher than those of groups A, B, and D, the differences were statistically significant (P＜0.008). Conclusion The blastocyst culture density is 4 to 5 blastocysts. The development potential of blastocysts is good. The results in all aspects are better that those of other quantities. Better, it means that the density of blastocyst culture should not be too high or too small.
2022 Vol. 29 (2): 109-112 [Abstract] ( 36 ) HTML (1 KB)  PDF (643 KB)  ( 7 )
113 Influence of applying liquid paraffin oil in the second stage of labor on the delivery outcome of cephalic dystocia
ZHOU Yuehuan;NI Yufang;YU Yumei
Objective To investigate the influence of applying liquid paraffin oil in the second stage of labor on the outcome of headposition dystocia. Methods The clinical data of 72 cases of patients with cephalic dystocia admitted to People′s Hospital of Fugong County of Nujiang Lisu Autonomous Prefecture in Yunnan Province from May to November 2020 were analyzed retrospectively. According to the different intervention methods of the second stage of labor, they were divided into the routine group (36 cases) and the paraffin group (36 cases). The routine group was treated with conventional intervention, and the paraffin group was treated with liquid paraffin oil to rotate the fetal head by hand on the basis of conventional intervention. The mode of delivery, the second stage of labor and the incidence of delivery complications were compared between the two groups. Results The difference in delivery mode between the two groups was statistically significant (P＜0.05). The second stage of labor in the paraffin group was shorter than that in the routine group, and the difference was statistically significant (P＜0.05). The perineal injury rate and neonatal asphyxia rate in the paraffin group were lower than those in the conventional group, and the differences were statistically significant (P＜0.05). Conclusion Using liquid paraffin oil to rotate the fetal head by hand in the second stage of dystocia at head position can significantly shorten the labor process and reduce the rate of cesarean section, reduce the degree of vaginal damage of puerpera, reduce the neonatal asphyxia rate, and improve the outcome of mother and baby.
2022 Vol. 29 (2): 113-115 [Abstract] ( 42 ) HTML (1 KB)  PDF (618 KB)  ( 20 )
116 Clinical effect of Azithromycin combined with Fluticasone Propionate on pediatric chronic cough caused by Mycoplasma pneumoniae infection
WU Xiaoling ;HUANG Cuilan ;WANG Zhenchun
Objective To investigate the effect of Azithromycin combined with Fluticasone Propionate on pediatric chronic cough caused by Mycoplasma pneumoniae (MP) infection. Methods A total of 126 children with MP infection and chronic cough admitted to the Department of Neonatology, the First Affiliated Hospital of Guangxi University of Science and Technology from September 2018 to August 2019 were selected as the research objects, and they were divided into observation group and control group by random number table method, 63 cases in each group. The control group was treated by Azithromycin, and the observation group was given the same but combined with Fluticasone Propionate. The clinical efficacy, fractional exhaled nitric oxide (FeNO), C-reactive protein (CRP), eosinophil (EOS) counts,and cough relapse rates of the two groups were compared. Results The total effective rate of the observation group was higher than that of the control group, the difference was statistically significant (P＜0.05). The serum CRP, EOS and FeNO in the observation group were lower than those of the control group, the differences were statistically significant(P＜0.05). The recurrence rate of cough in the observation group was lower than that in the control group, the difference was statistically significant (P＜0.05). Conclusion The treatment of Azithromycin combined with Fluticasone Propionate in children with chronic cough with MP infection can further improve the treatment effect and reduce the recurrence.
2022 Vol. 29 (2): 116-118 [Abstract] ( 51 ) HTML (1 KB)  PDF (659 KB)  ( 21 )
119 Analysis of the clinical effect of highly selective branches neurotomy of vidian nerve in the treatment of vasomotor rhinitis
LAN Ning;LIAO Pengfei;GUO Lingyun;CHEN Weibin

Objective To analyze the clinical effect of highly selective branches neurotomy of vidian nerve in the treatment of vasomotor rhinitis. Methods Sixty patients with vasomotor rhinitis who were treated in People′s Hospital of Yichun City from June 2019 to March 2020 were selected and divided into the control group and the observation group according to the random number table method, with 30 cases in each group. The patients of the control group were treated with inferior turbinate ablation and nasal septum correction. The patients of the observation group were treated with highly selective branches neurotomy of vidian nerve. Patients of both groups were followed up for 12 months. Before the operation (T0), 1 month after operation (T1), 3 months after operation (T2), 6 months after operation (T3) and 12 months after operation (T4), the symptoms, signs score and visual analog scale (VAS) scoreand the postoperative complications of the two groups were compared. Results There were statistically significant differences in the time, intergroup and interaction of the scores of symptoms and signs between the two groups (P<0.05). Further pairwise comparison, there were no statistically significant differences in the scores of symptoms and signs between the two groups at T0 (P>0.05). The scores of symptoms and signs of the two groups at T1 were higher than those at T2, the scores of symptoms and signs at T2 were higher than those at T3, and the scores of symptoms and signs at T3 were higher than those at T4, and the differences were statistically significant (P<0.05). At T1, T2, T3 and T4, the scores of symptoms and signs in the observation group were lower than those in the control group, and the differences were statistically significant (P<0.05). There were statistically significant differences in the time, intergroup and interaction of the VAS score between the two groups (P<0.05). Further pairwise comparison, there was no statistically significant difference in VAS score at T0 between the two groups (P>0.05). VAS scores of the two groups at T0 were higher than those at T1, VAS scores at T1 were higher than those at T2, VAS scores at T2 were higher than those at T3, VAS scores at T3 were higher than those at T4, and the differences were statistically significant (P<0.05). VAS scores of the observation group were lower than those of the control group at T1, T2, T3 and T4, and the differences were statistically significant (P<0.05). The total incidence of postoperative complications in the observation group was lower than that in the control group, and the difference was statistically significant (P<0.05). Conclusion In patients with vasomotor rhinitis, the treatment effect of highly selective branches neurotomy of vidian nerve is better, which can adjust the clinical symptoms and signs of patients, alleviate pain, and has better safety.
2022 Vol. 29 (2): 119-122 [Abstract] ( 36 ) HTML (1 KB)  PDF (426 KB)  ( 103 )
123 Clinical effect of pterygium resection combined with corneal limbal stem cell transplantation in the treatment of pterygium
ZHOU Dayan
Objective To investigate the clinical effect of pterygium resection combined with limbal stem cell transplantation in the treatment of pterygium. Methods The clinical data of 238 patients with pterygium who were treated in the Department of Ophthalmology of Jianli Third People′s Hospital from July 2015 to December 2019 were selected for retrospective analysis. According to different surgical methods, they were divided into observation groups (n=119, 141 eyes)and the control group (n=119, 140 eyes). The control group used triamcinolone acetonide marked pterygium resection combined with pedicled conjunctival flap transfer, and the observation group pterygium resection combined with limbal stem cell transplantation, the clinical efficacy, total complication incidence, recurrence rate, epithelial repair time and hospitalization time of the two groups were compared, and the postoperative naked eye vision and corneal astigmatism of the two groups were compared. Results The total effective rate of treatment in the observation group was higher than that in the control group, the difference was significant (P＜0.05). The hospitalization time, corneal epithelial repair time, and recurrence rate of the observation group were lower than those of the control group, the differences were significant (P＜0.05). There was no statistically significant difference between the two groups in the incidence of complications, corneal astigmatism and uncorrected visual acuity one month after surgery (P＞0.05). Conclusion Limbal stem cell transplantation can improve the therapeutic effect of patients with pterygium, and has positive significance in reducing the recurrence rate after surgery and shortening the recovery time of the disease.
2022 Vol. 29 (2): 123-126 [Abstract] ( 50 ) HTML (1 KB)  PDF (420 KB)  ( 41 )
127 Diagnostic value of alveolar-arterial blood oxygen pressure difference in pneumoconiosis
CHEN Yong
Objective To explore the diagnostic value of alveolar-arterial blood oxygen pressure (A-aDO2) difference in pneumoconiosis. Methods A total of 40 pneumoconiosis patients in Shaoguan occupational disease prevention and control hospital from January 2020 to December 2020 were selected as the observation group, and 40 patients with the same dust contact conditions admitted in Shaoguan Occupational Disease Prevention Hospital from January to December 2020 were selected as control group. The partial pressure of carbon dioxide (PaCO2), arterial oxygen partial pressure(PaO2), A-aPO2, forced expiratory volume in one second (FEV1), and forced vital capacity (FVC) values of the two groups were detected, the ROC curve was drawn to analyze the diagnostic efficacy of PaCO2, PaO2 and A-aDO2. Results PaO2 in the observation group was lower than that in the control group, with statistical significant difference (P＜0.05). PaCO2 and A-aDO2 in the observation group were higher than those in the control group, with statistical significant differences (P＜0.05). FEV1 and FVC in the observation group were lower than those in the control group (P＜0.05).The PaO2, PaCO2, A-aDO2 of pneumoconiosis patients′ AUC and sensitivity were 0.788 and 86%, 0.863 and 87%,0.873 and 98%. Conclusion A-aDO2 has good diagnostic value in pneumoconiosis patients. The AUC and sensitivity of A-aDO2 are significantly higher than those of PaCO2 and PaO2. Early monitoring of A-aDO2 is helpful to early diagnose pneumoconiosis, evaluate the pulmonary function of pneumoconiosis patients, judge the progress and prognosis of the disease, so as to treat pneumoconiosis in time.
2022 Vol. 29 (2): 127-129 [Abstract] ( 38 ) HTML (1 KB)  PDF (494 KB)  ( 36 )
130 Changes of serum lipase, serum amyloid A, and transferrin levels in patients with acute pancreatitis and their correlation with the severity of the disease
LIU Jianhuan; CHEN Wanchan ;YIN Aiping ;Pu Rong ;LIANG Yixian▲
Objective To study the changes in serum lipase, serum amyloid A, and transferrin levels in patients with acute pancreatitis and their correlation with the severity of the disease. Methods A total of 80 patients with acute pancreatitis admitted to Dongguan Songshan Lake Central Hospital from January 2020 to February 2021 were selected as the observation group. According to the severity of acute pancreatitis, the observation group was divided into mild acute pancreatitis (MAP) group (47cases) and severe acute pancreatitis (SAP) group (33 cases), a total of 92 healthy people with physical examination during the same period were selected as the control group. The serum lipase, serum amyloid A, and transferrin levels of the three groups were compared, and the correlation between the serum lipase, serum amyloid A, and transferrin levels with the severity of the disease were analyzed. Results Serum lipase and serum amyloid A in SAP group were higher than those in MAP group and control group, and transferrin was lower than that in the MAP group and control group, the differences were statistically significant (P＜0.05). Serum lipase and amyloid A starch in MAP group were higher than those of the control group, and transferrin was lower than that in the control group, the differences were statistically significant (P＜0.05). Serum lipase and serum amyloid A in patients with acute pancreatitis were positively correlated with the severity of the disease, and the level of transferrin was negatively correlated with the severity of the disease (P＜0.05). Conclusion The levels of serum lipase, serum amyloid A and transferrin are higher in patients with SAP. The changes in serum lipase, serum amyloid A and transferrin levels are related to the severity of the disease and play a role in the diagnosis of acute pancreatitis It plays an important role and has high reference value for clinical practice.
2022 Vol. 29 (2): 130-132转136 [Abstract] ( 44 ) HTML (1 KB)  PDF (513 KB)  ( 16 )
133 Plasma the diagnostic value of von Willebrand factor antigen, D-dimer,and fibrinogen/fibrin degradation products tests in acute cerebral infarction
WANG Jujin ;KUANG Jia; YANG Yeyi; XU Gang▲
Objective To explore the plasma the diagnostic value of von Willebrand factor antigen (vWF:Ag), D-dimer(D-D), and fibrinogen/fibrin degradation products (FDP) tests in acute cerebral infarction. Methods Eighty-six cases of patients with acute cerebral infarction admitted to Baoshan Branch of Shanghai Renji Hospital from April 2019 to December 2020 were selected as the observation group, and 86 cases of acute cerebral infarction admitted to Baoshan Branch of Shanghai Renji Hospital from April 2019 to December 2020 were selected as the observation group, and 60 physical examination patients of Baoshan Branch of Shanghai Renji Hospital from April 2019 to December 2020 were selected as the control group. The plasma vWF:Ag, D-D and FDP concentration; three indexes for correlation analysis were compared; draw ROC curve, analyze the diagnostic efficacy of vWF:Ag, D-D and FDP levels in patients with acute cerebral infarction and perform logistic regression analysis. Results The vWF:Ag, D-D, and FDP levels in the observation group were higher than those in the control group, with statistically significant differences (P＜0.05). The vWF:Ag was positively associated with D-D levels (r=0.95, P＜0.05), while the vWF:Ag had no correlation with FDP (r=0.54,P＞0.05), D-D had no correlation with FDP (r=0.68, P＞0.05). The logistic regression analysis showed that the vWF:Ag and D-D were the related risk factors for developing ACI (P＜0.05). Conclusions Plasma vWF:Ag, D-D and FDP have certain clinical diagnostic value in the test of patients with acute myocardial infarction, and vWF:Ag and D-D tests may be risk factors for acute cerebral infarction and serve as predictors of clinical diagnosis.
2022 Vol. 29 (2): 133-136 [Abstract] ( 39 ) HTML (1 KB)  PDF (952 KB)  ( 26 )
137 Study on the value of microbiological examination technology in the clinical diagnosis of Helicobacter pylori in chronic gastritis
RAO Jingjing
Objective To explore the value of microbiological examination technology in the clinical diagnosis of Helicobacter pylori (Hp) in chronic gastritis. Methods A total of 50 confirmed patients with chronic gastritis admitted to Jingmen Hospital of Traditional Chinese Medicine from January 2019 to January 2021 were selected as the research objects, and perform gastroscopy and microbiological testing for all patients. Gastroscopy waas the gold standard, and the accuracy, sensitivity and specificity of ultracentrifugation and isolation culture were compared. Results There were 27 Hp-positive patients and 23 Hp-negative patients with the gold standard. In the ultracentrifugation culture, there were 27 patients with Hp positive and 22 patients with Hp-negative. The accuracy of ultracentrifugation culture was 98.00% (49/50), the sensitivity was 100.00% (27/27), and the specificity was 95.65% (22/23). In the isolation culture,there were 28 cases were Hp-positive patients and 22 cases were Hp-negative patients. The accuracy of isolation culture was 94.00% (47/50), the sensitivity was 96.29% (26/27), and the specificity was 91.30% (21/23). There was no statistically significant difference in the accuracy, sensitivity, and specificity of ultracentrifugation culture and insolation culture (P>0.05). There was no statistically significant difference between the test satisfaction scores of ultracentrifugation culture and insolation culture (P>0.05). Conclusion In the diagnosis of Hp in patients with chronic gastritis, the auxiliary diagnosis is completed by means of ultracentrifugation culture and insolation culture, which can effectively evaluate the clinical situation of the patient′s Hp infection and provide feedback on the patient′s pathogenic bacteria..
2022 Vol. 29 (2): 137-139 [Abstract] ( 49 ) HTML (1 KB)  PDF (493 KB)  ( 29 )
140 Status quo and correlation analysis of the empowerment and frailty in the middle-aged and elderly patients with chronic heart failure
XIAO Guifang; YANG Yiqin;HU Pingping
Objective To explore the status of the empowerment and frailty in middle-aged and elderly patients with chronic heart failure, and analyze the correlation between them. Methods A total of 187 middle-aged and elderly patients with chronic heart failure in the Department of Cardiovascular, Guangdong Second Traditional Chinese Medicine Hospital from March 2020 to February 2021 were selected and evaluated by patient empowerment scale and infirmity assessment scale. Pearson correlation analysis and multiple linear regression analysis were used to explore the influence of empowerment on infirmity. Results The empowerment score of middle-aged and elderly patients with chronic heart failure was (109.17±11.23) points, including 182 patients with ≤160 points (97.3%), and the frailness score was (61.68±14.34) points, with a scoring rate of 63.6%. There were statistically significant differences in fadiness scores of patients with different age, complication, heart function grade and self-care ability (P＜0.05). The scores of empowerment dimensions were negatively correlated with those of weakness dimensions (P＜0.05). Doctor-patient relationship management ability, social support, role recognition, medical decision-making participation and patient support were the independent factors of frailty (P＜0.05). Conclusion The empowerment ability of the middle-aged and old patients with chronic heart failure were relatively poor, and the frailty situation were relatively serious. Clinical medical staff should pay attention to improving the patient′s empowerment level to reduce the adverse effects of frailty.
2022 Vol. 29 (2): 140-143转148 [Abstract] ( 41 ) HTML (1 KB)  PDF (582 KB)  ( 30 )
144 Comparative study on the dignity, quality of life and psychological status of patients with advanced lung cancer
JI Juan ;FAN Guohua; XU Wenjing; LU Lanping
Objective To investigate and compare the distinctions of dignity, quality of life and psychological status of patients with advanced lung cancer in different age groups, and to provide basis for personalized nursing. Methods A total of 156 patients with advanced lung cancer admitted to Subei People′s Hospital from September 2019 to July 2020 were selected as the research subjects. According to the international age grouping standard, they were divided into young and middle-aged group (40-59 years old, 70 cases) and old group (≥60 years old, 86 cases). General information, patient dignity inventory (PDI), quality of life questionnaire (QLQ-C30), lung cancer patient quality of life questionnaire (QLQ-L13) and hospital anxiety and depression scale (HADS) scores were compared between the two groups.Results The dignity of 62.79% of the elderly group was significantly impaired, and the scores of PDI, symptom distress,mental tranquility and social support in the elderly group were higher than those in the young and middle-aged group,and the differences were statistically significant (P＜0.05). The scores of overall quality of life, emotional function and hair loss in the elderly group were lower than those in the young and middle-aged group, while the scores of shortness of breath and hemoptysis were higher than those in the young and middle-aged group, and the differences were statistically significant (P＜0.05). The depression score of the elderly group was higher than that of the young and middle-aged group, and the difference was statistically significant (P＜0.05). There was no statistically significant difference in anxiety scores between the two groups (P＞0.05). Conclusion The dignity level, quality of life and psychological state of middle-aged, young and elderly patients with advanced lung cancer are impaired to varying degrees, especially the elderly patients. It is necessary to pay attention to targeted personalized nursing measures to improve the dignity level of patients with advanced lung cancer, improve the quality of life, and avoid the occurrence of bad emotions.
2022 Vol. 29 (2): 144-148 [Abstract] ( 58 ) HTML (1 KB)  PDF (571 KB)  ( 10 )
149 Qualitative research on the cognitive experience of community female breast cancer screening
DONG Le; FAN Min; PU Yucui ;JIANG Lifang; WANG Rong▲
Objective To understand the awareness of community women′s breast cancer related knowledge and the obstacles in the screening process, to provide references for improving the breast cancer screening rate and awareness of community women. Methods Using the semi-structured interview method, in-depth interviews were conducted with 14 community women from March to April 2021. Results A total of three themes were extracted, included nsufficient knowledge of breast cancer related knowledge, low breast cancer screening rate, various factors affecting breast cancer screening. Conclusion Community women have insufficient awareness of breast cancer and weak willingness to screen for breast cancer. The community should increase the importance of community women on breast cancer screening, formulate targeted measures, guide women in the community to form regular screening behaviors, and provide science for early prevention and intervention of community women′s breast cancer based on the relevant factors that affect women′s breast cancer screening.
2022 Vol. 29 (2): 149-152 [Abstract] ( 42 ) HTML (1 KB)  PDF (595 KB)  ( 68 )
153 Investigation on mental health status of emergency nurses and analysis of related influencing factors
SUN Jinxing
Objective To explore the mental health status and related influencing factors of emergency nurses. Methods From January to February 2021, 100 nurses in the emergency department of 6 hospitals in Xinghua were selected to investigate the basic data and mental health status of nurses. According to the scoring results of symptom checklist 90(SCL-90), nurses were divided into good mental health group and poor mental health group. The basic data of the two groups, such as gender, age, marital status, educational background, working years, family/social support, fear of infectious diseases, stimulation of near death or death phenomena, interpersonal skills, satisfaction with work arrangements,and self-regulation of work pressure were compared. The influencing factors of mental health status of emergency nurses were analyzed. Results Among the 100 emergency nurses, 29 cases were found to have poor mental health, accounting for 29.00%. The proportion of working years ＜5 years, lack of family/social support, fear of infectious diseases,stimulation of near death or death, lack of interpersonal communication ability, dissatisfaction with work arrangement and lack of self-regulation of work pressure in the group with poor mental health was higher than that in the group with good mental health (P＜0.05).Multivariate logistic regression analysis showed that working years ＜5 years,lack of family/social support, fear of infectious diseases, stimulation of near death or death, lack of interpersonal communication ability, dissatisfaction with work arrangement and lack of self-regulation of work pressure were independent risk factors affecting the mental health of emergency nurses (P＜0.05).Conclusion the mental health status of emergency nurses is not ideal. The main influencing factors are working years ＜5 years, lack of family/social support, fear of infectious diseases, stimulation of near death or death, lack of interpersonal communication ability, dissatisfaction with work arrangement and lack of ability to self regulate work pressure. The nursing department should pay great attention to it.
2022 Vol. 29 (2): 153-156 [Abstract] ( 50 ) HTML (1 KB)  PDF (557 KB)  ( 54 )
157 Study on the compliance rate and the influencing factors of elderly hypertension patients in Leshan City
ZHU Shuangyan ;LI Yan; HE Jing ;SHAO Xin
Objective To explore the study on the compliance rate and the influencing factors of elderly hypertension patients in Leshan City. Methods A total of 205 elderly hypertension patients in Leshan from January to May 2021 were selected as the study subjects, and divided into the standard groups (106 cases) and the substandard group (99 cases) according to the blood pressure control situation. The 14 indicators of gender, age, culture, and occupation were compared between the two groups, and the factors influencing blood pressure control in elderly hypertensive patients were analysed. Results The results of univariate analysis showed that gender, age, education, occupation, residence,medical payment method, body mass index (BMI), diabetes, hyperlipidemia, smoking and alcohol consumption were related factors affecting the blood pressure control in elderly hypertensive patients (P＜0.05). The results of the multivariate analysis showed that age, education, occupation, medical payment method, and BMI were independent imaging factors affecting blood pressure control in elderly hypertensive patients (P＜0.05). Conclusion The blood pressure control of elderly patients with hypertension is affected by many factors, so it is necessary to strengthen education and guidance,take measures according to local conditions, and adopt more effective health management strategies.
2022 Vol. 29 (2): 157- [Abstract] ( 45 ) HTML (1 KB)  PDF (557 KB)  ( 7 )
161 Analysis of irregular antibody results of blood transfusion patients in Liaoyang Central Hospital from 2017 to 2020
GUO Jiuying
Objective To comprehend the distribution characteristics of the positive results of irregular antibody screening in blood transfusion patients in Liaoyang Central Hospital, and to explore the measures to promote clinical safe and effective blood use. Methods A total of 14 235 blood transfusion patients admitted to Liaoyang Central Hospital from January 2017 to December 2020 were selected as the study subjects, and the irregular antibody screening and antibody identification results were counted, and the types and distribution characteristics of irregular antibodies were analyzed.Results The positive rate of irregular antibody screening was 0.76%(108/14235). The positive rate of female patients was higher than that of male patients, and the difference was statistically significant (P＜0.05). Among them, Rh system antibody reached 93 cases at most, accounting for 86.11% (93/108). The positive rate of antibody in patients with more than 3 blood transfusions was higher than that in patients with less than 3 blood transfusions, and the difference was statistically significant (P＜0.05). Conclusion The positive rate of irregular antibody screening in patients with repeated blood transfusion and female patients is on the high side. Therefore, it is recommended to give Rh homotype blood transfusion to patients with repeated blood transfusion, so as to reduce the production of irregular antibody and improve the safety of blood transfusion.
2022 Vol. 29 (2): 161-163 [Abstract] ( 39 ) HTML (1 KB)  PDF (594 KB)  ( 9 )
164 Application study of rapid rehabilitation combined continuing care in patients with minimally invasive knee replacement arthroplasty
RAO Weixia; PAN Haifang ;CHEN Min
Objective To explore the application of rapid rehabilitation combined continuing care in patients with minimally invasive knee replacement. Methods A total of 60 patients undergoing knee arthroplasty in the Second Affiliated Hospital of Nanchang University from November 2019 to November 2020 were selected and divided into the control group and the observation group according to a random number table, with 30 cases in each group. The control group used routine nursing care, and theobservation group used rapid rehabilitation combined with continuous nursing to compare the surgical conditions, self-care ability, quality of life and complications between the two groups. Results The observation group′s time to get out of bed and hospital stay were shorter than those of the control group, and the hospitalization expenses was less than that of the control group, the differences were statistically significant (P＜0.05). The pain score of the observation group was lower than that of the control group at 3 d after surgery, the difference was statistically significant (P＜0.05). After nursing, the scores of health knowledge, self-care responsibility, self-concept and self-care skills in the observation group were higher than those of the control group, and the differences were statistically significant (P＜0.05). After nursing, the social, cognitive, physical and role function scores of the observation group were higher than those of the control group, and the differences were statistically significant (P＜0.05). The total incidence of complications in the observation group was lower than that of the control group, and the difference was statistically significant (P＜0.05). Conclusion Rapid rehabilitation combined with continuing care can effectively reduce the pain of minimally invasive knee arthroplasty patients, shorten the hospital stay, reduce the economic burden of patients,improve self-care ability and quality of life, and reduce the incidence of postoperative complications.
2022 Vol. 29 (2): 164-167 [Abstract] ( 41 ) HTML (1 KB)  PDF (611 KB)  ( 98 )
168 Effect of continuous nursing based on WeChat platform on compliance behavior and self-care ability of patients with chronic heart failure
YU Yuehui ;WANG Xiaoxin ;ZHANG Chong ;WANG Xiaoxi ;ZHAO Hongli
Objective To explore the effect of continuous nursing based on WeChat platform on compliance behavior and self-care ability of patients with chronic heart failure. Methods A total of 196 patients with chronic heart failure admitted to the Second Affiliated Hospital of Shenyang Medical College from January 2019 to December 2020 were selected as the study subjects, and they were divided into control group and study group by random number table method, with 98 cases in each group. The patients in the control group were treated with routine nursing intervention,and the patients in the study group were treated with continuous nursing based on WeChat platform. The scores of compliance behavior, self-care ability and total nursing satisfaction were compared between the two groups. Results There were no statistically significances in compliance behavior score and self-care ability score between the two groups before nursing (P＞0.05). The scores of compliance behavior and self-care ability of patients in both groups after nursing were higher than those before nursing, with statistical significances (P＜0.05). The scores of compliance behavior and self-care ability of patients in the study group were higher than those in the control group after nursing, with statistical significances (P＜0.05). The total nursing satisfaction of patients in the study group was 96.94%, which was higher than 88.78% in the control group, and the difference was statistically significant (P＜0.05). Conclusion The application of continuous nursing based on WeChat platform can improve the compliance behavior and self-care ability of patients with chronic heart failure, with high patient satisfaction, which is worthy of promotion.
2022 Vol. 29 (2): 168-170转181 [Abstract] ( 47 ) HTML (1 KB)  PDF (621 KB)  ( 33 )
171 Application effect of fast track surgery strategy in perioperative nursing of laparoscopic radical prostatectomy for prostate cancer
XIANG Junlian
Objective To investigate the application effect of fast track surgery (FTS) strategy in perioperative nursing of laparoscopic radical prostatectomy (LRP) for prostate cancer. Methods A total of 49 LRP patients who were admitted to Deyang People′s Hospital, Sichuan Province from January 2014 to December 2019 were selected as the study subjects,and they were divided into the control group(24 cases)and the study group(25 cases)by the random number table method.The control group was treated with routine nursing, while the study group was treated with FTS nursing. The postoperative pain scores, perioperative recovery indexes and postoperative complications were compared between the two groups,and the patients′nursing satisfaction was counted. Results The pain score of patients in the study group was lower than that in the control group at 3 and 7 d after surgery, and the differences were statistically significant (P＜0.05). The first time to eat, time to get out of bed and duration of hospital stay in the study group were shorter than those in the control group, and the differences were statistically significant (P＜0.05). There was no significant difference in the total incidence of postoperative complications between the two groups (P＞0.05). The nursing total satisfaction of the study group was higher than that of the control group, and the difference was statistically significant (P＜0.05). Conclusion The application of FTS to the perioperative nursing of LRP can relieve postoperative pain, ensure patients′ safety, shorten the recovery time of patients, promote the fast recovery of patients, and improve the nursing satisfaction of patients.
2022 Vol. 29 (2): 171-174 [Abstract] ( 50 ) HTML (1 KB)  PDF (609 KB)  ( 48 )
175 Application effect of 3D first aid mode in rescue of chest pain center
LU Xiaohua ;XIAO Luming;XIE Junjun; HUANG Weizhong ;CHENG Jun ;TAN Li
Objective To discuss the application effect of 3D first aid mode in the rescue of chest pain center. Methods A total of 58 patients with chest pain admitted to the chest pain center of Department of Emergency in People′s Hospital of Yingde City from April to August 2019 were selected as the observation group, and 37 patients with chest pain admitted to the same hospital from January 2017 to June 2018 when chest pain center wasn′t established were selected as the control group. The control group used conventional first aid procedures, and the observation group used the 3D first aid mode of the chest pain center. The door to balloon time (D to B time), the time from the first medical contact to the first electrocardiogram, the time from the completion of the first electrocardiogram to the first electrocardiogram diagnosis, troponin acquisition time, catheter room activation time and remote transmission ratio of the two groups were compared. Results The observation group′s D to B time, the first medical contact to the first electrocardiogram time, the first electrocardiogram completion to the first electrocardiogram diagnosis time, troponin acquisition time and catheter room activation time were shorter than those of the control group, and the remote transmission ratio was higher than that of the control group, the differences were statistically significant (P＜0.05). Conclusion The 3D first aid mode is used in the rescue of chest pain centers, which is beneficial to shorten the time required for various diagnosis and treatment links, improve the efficiency of treatment, and is worthy of clinical application.
2022 Vol. 29 (2): 175-177 [Abstract] ( 39 ) HTML (1 KB)  PDF (613 KB)  ( 9 )
178 Effect of humanized high-quality nursing service on the length of hospital stay and satisfaction in patients with respiratory failure
SHENG Chen
Objective To explore the effect of humanized high-quality nursing service on the length of hospital stay and satisfaction in respiratory failure. Methods A total of 64 cases of patients with respiratory failure admitted to Guangzhou First People′s Hospital from February 2019 to February 2021 were selected, and they were divided into the control group and the study group by random number table method, 32 cases in each group. The control group was given routine nursing, and the study group was given humanized high-quality nursing service. The blood oxygen partial pressure, blood carbon dioxide partial pressure, the length of hospital stay, bad mood and nursing satisfaction were compared between the two groups. Results The partial pressure of blood carbon dioxide in the study group was lower than that in the control group, the partial pressure of blood oxygen in the study group was higher than that in the control group, and the length of hospital stay in the study group was shorter than that in the control group, the differences were statistically significant (P＜0.05). The score of bad mood in the study group after intervention was lower than that in the control group, the difference was statistically significant (P＜0.05). The total of nursing satisfaction of the study group was higher than that of the control group, the difference was statistically significant (P＜0.05). Conclusion For patients with respiratory failure, the effect of humanized high-quality nursing service in nursing is remarkable, which can improve patients′ blood gas indicators and bad mood, shorten the length of hospital stay and improve total of nursing satisfaction. It is worthy of popularization and application.
2022 Vol. 29 (2): 178-181 [Abstract] ( 49 ) HTML (1 KB)  PDF (608 KB)  ( 10 )
182 Effect of Gibbs reflection cycle mode on improving disease uncertainty and treatment compliance in the elderly undergoing gastrointestinal surgery
ZHANG Lijuan
Objective To study and observe the effect of Gibbs reflection cycle mode on improving disease uncertainty and treatment compliance in the elderly undergoing gastrointestinal surgery. Methods A total of 118 elderly patients underwent gastrointestinal surgery in Beipiao Central Hospital were enrolled from June 2018 to July 2020. They were divided into the observation group and the control group according to random number table method, 59 cases in each group. The control group was given routine nursing, while the observation group was given Gibbs reflection cycle mode for nursing intervention. The total incidence of complications during intervention, postoperative recovery, disease uncertainty, treatment compliance and quality of life were compared between the two groups. Results The total incidence of complications during intervention in the observation group was lower than that in the control group, the difference was statistically significant (P＜0.05). The recovery time of postoperative bowel sound, recovery time of exhaust and defecation, leaving bed time and hospitalization time in the observation group were shorter than those in the control group, the differences were statistically significant(P＜0.05).The score of disease uncertainty in the observation group was lower than that in the control group, and the scores of treatment compliance and quality of life in the observation group were higher than those in the control group, the differences were statistically significant (P＜0.05). Conclusion Gibbs reflection cycle mode can improve disease uncertainty, treatment compliance and quality of life in elderly patients undergoing gastrointestinal surgery,and patients have fewer postoperative complications and can recover from hospital more quickly.
2022 Vol. 29 (2): 182-186 [Abstract] ( 37 ) HTML (1 KB)  PDF (630 KB)  ( 169 )
187 Application of nursing emergency plan and primary nursing model in the rescue of high-risk obstetric patients
WEN Wen
Objective To analyze the value of implementing nursing emergency plan combined with primary nursing in the rescue of high-risk obstetric patients. Methods A total of 66 high-risk obstetric patients who were admitted in our hospital from September 2018 to June 2020 were selected as the research subjects. According to the random number table, the obstetric patients were divided into group A (n=33) and group B (n=33). In the group A, the obstetric patients were provided with routine care. In the group B, emergency plan combined with primary nursing was adopted. Disease knowledge mastery, nursing quality, satisfaction, and breastfeeding situation were compared in the two groups. Results The total mastery of disease knowledge in the group B was higher than that in the group A, and the difference was statistically significant (P＜0.05). The nursing quality score of the group B was higher than that of the group A, and the difference was statistically significant (P＜0.05). The total nursing satisfaction of the group B was higher than that of the group A, and the difference was statistically significant (P＜0.05). The breastfeeding success rate of the group B was higher than that of the group A, and the difference was statistically significant (P＜0.05). The lactation yield of the group B was more than that of group A, and the difference was statistically significant (P＜0.05). The initiation of lactation in group B was earlier than that in group A, and the difference was statistically significant (P＜0.05). Conclusion In the rescue of high-risk patients in obstetrics, the implementation of emergency nursing plan combined with primary care can improve the patient′s knowledge of disease, the quality of care, satisfaction, and the success rate of breastfeeding,and can promote lactation.
2022 Vol. 29 (2): 187-189转193 [Abstract] ( 40 ) HTML (1 KB)  PDF (622 KB)  ( 159 )
190 Application of predictive risk care in elderly patients with coronary heart disease
ZENG Sijin
Objective To observe the effect of predictive risk care in elderly patients with coronary heart disease.Methods A total of 160 elderly patients with coronary heart disease who were admitted to the First Affiliated Hospital of Xiamen University from October 2018 to October 2020 were selected as the research objects. They were divided into the control group and the observation group by random number table method, with 80 cases in each group. Patients in control group received routine nursing mode, and patients in observation group received predictive risk nursing mode.The cardiac function related indicators, medical compliance behavior and quality of life score were compared between the two groups. Results Before nursing, there were no statistically significant differences in cardiac function index,compliance behavior score and quality of life score between the two groups (P＞0.05). After nursing, the left ventricular ejection fraction (LVEF), early diastolic/late diastolic maximum blood flow peak (E/A), compliance behavior score and quality of life score in the observation group were higher than those in the control group, and the differences were statistically significant (P＜0.05). After nursing, the left ventricular end diastolic diameter (LVEDD) of the two groups was lower than that before nursing, and the observation group was lower than the control group, the differences were statistically significant (P＜0.05). Conclusion Predictive risk nursing model has significant nursing effect on elderly patients with coronary heart disease, which is helpful to improve the quality of life of patients.
2022 Vol. 29 (2): 190-193 [Abstract] ( 48 ) HTML (1 KB)  PDF (610 KB)  ( 42 )
194 Application effect of comfort nursing in patients with appendicitis surgery
MA Dan; WANG Yang; LI Shuping ;LI Jia
Objective To explore the effect of comfortable nursing in patients with appendicitis surgery (AS). Methods A total of 124 appendicitis surgery patients who were admitted to Hongqi Hospital Affiliated to Mudanjiang Medical College from December 2017 to April 2020 were selected as the research subjects, and they were divided into experimental group and control group according to random number table method, with 62 cases in each group. The control group received conventional basic intervention to complete the surgical treatment, and the experimental group was treated with comfortable nursing to complete the surgical treatment. The generalized anxiety disorder-7 (GAD-7) score,Chinese perceived stress scale (CPSS) score, general comfort questionnaire (GCQ) score, verbal descriptors scale (VDS)score and the total rate of complications between the two groups were compared. Results The GAD-7 score, CPSS score, VDS score and the total complication rate of experimental group after intervention were all lower than those of control group, the differences were statistically significant (P＜0.05). The GCQ score of experimental group after intervention was higher than that of control group, the difference was statistically significant (P＜0.05). Conclusion The combined application of comfort nursing in AS patients can improve their comfort and safety, and reduce their pain and psychological pressure.
2022 Vol. 29 (2): 194-196 [Abstract] ( 38 ) HTML (1 KB)  PDF (603 KB)  ( 39 )
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