体重指数对行体外受精/卵胞浆内单精子显微注射技术治疗患者人绒毛膜促性腺激素日激素水平的影响

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Abstract Objective To analyze the effect of the different body mass index (BMI) on estradiol (E2), luteinizing hormone (LH) and progesterone (P) values in females who received in vitro fertilization/intracytoplasmic sperm injection(IVF/ICSI) treatment on human chorionic gonadotropin (HCG) day. Methods A total of 1307 cycles of IVF/ICSI conducted in our reproductive center were retrospectively analyzed. Based on the age, female infertility patients were divided into the group of the age ≤35 years old and the group of the age ＞35 years old. Then based on the different BMI, the two groups were further divided into three subgroups: normal weight group (18.5 kg/m2≤BMI＜23 kg/m2),overweight group (23 kg/m2≤BMI＜25 kg/m2) and obese group (BMI≥25 kg/m2). The effect of BMI in different age groups on the hormone level of HCG day were observed. Results There were statistically significant differences in E2 levels of infertile women aged ≤35 years, normal weight group, overweight group and obese group (P＜0.05). The level of E2 in obese group was lower than that in normal group and overrecombinant group, and the difference was statistically significant (P＜0.05). The P level of HCG in the three subgroups was statistically significant (P＜0.05). The P level of obese group was lower than that of normal group and overreorganization group, and the difference was statistically significant (P＜0.05). There was no statistically significant difference in LH on HCG day among the three subgroups (P＞0.05), and there was no statistically significant difference in pregnancy rate among the three subgroups(P＞0.05). There was significant difference in HCG day P level among infertile women aged ＞35 years, normal weight group, overweight group and obese group (P＜0.05). The P level of normal group was higher than that of overweight and obesity group, the difference was statistically significant (P＜0.05). There was no significant difference in E2 and LH levels among the three subgroups on HCG day (P＞0.05), and there was no significant difference in pregnancy rate among the three subgroups (P＞0.05). Correlation analysis showed that BMI was negatively correlated with E2 and P on HCG day(P＜0.05). Partial correlation analysis after age control showed that BMI was negatively correlated with E2 and P on HCG day (P＜0.05). Conclusion For infertile women treated with IVF/ICSI, serum E2 and P levels on HCG day decreased with the increase of BMI, BMI does not affect serum LH level on HCG day, and BMI has not been found to affect pregnancy outcome.

Key words： In vitro fertilization/intracytoplasmic sperm injection Body mass index Human chorionic gonadotropin day Estradiol Luteinizing hormone Progesterone Pregnancy outcome

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	HUANG Ying
	LAO Kaixue
	WANG Yanlin▲

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HUANG Ying,LAO Kaixue,WANG Yanlin▲. Effect of body mass index on hormone level of patients on human chorionic gonadotropin day with in vitro fertilization/intracytoplasmic sperm injection treatment[J]. 中国当代医药, 2022, 29(2): 24-28.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2022/V29/I2/24

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