美沙拉嗪结合锡类散灌肠治疗溃疡性结肠炎的效果及对患者免疫功能和细胞因子的影响

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Abstract Objective To explore the effect of Mesalazine combined with Tin Powder enema in the treatment of ulcerative colitis (UC) and its influence on the immune function and cytokines of patients. Methods A total of 76 patients with UC who were diagnosed and treated in Wujin Hospital Affiliated to Jiangsu University from January 2018 to January 2021 were selected as the research subjects. According to the random number table method, they were divided into a control group and a study group, with 38 cases in each group. The control group was treated with Mesalazine, and the study group was treated with Tin Powder enema on the basis of the control group. The clinical efficacy, helper T cells (Th17) and regulatory T cells (Treg), T cell subsets (CD4+, CD8+, CD4+/CD8+), natural killer cell (NK) levels, immunoglobulin (Ig) A, IgG, IgM levels, serum interleukin (IL)-10, IL-18, IL-6, IL-4, and tumor necrosis factor-α(TNF-α) and the occurrence of adverse reactions were compared between the two groups. Results The total effective rate of study group was 92.11%, which was higher than that of control group (68.42%), and the difference was statistically significant (P＜0.05). The expression level of Th17 in the study group after treatment was lower than that in the control group, and the difference was statistically significant (P＜0.05). The expression level of Treg in the study group after treatment was higher than that in the control group, and the difference was statistically significant (P＜0.05). After treatment, CD4+, CD4+/CD8+ and NK levels in the study group were higher than those in the control group, while CD8+level in the study group was lower than that in the control group, the differences were statistically significant (P＜0.05).The levels of IgA, IgG and IgM in the study group after treatment were lower than those in the control group, and the differences were statistically significant (P＜0.05). The levels of IL-10 and IL-4 in the study group after treatment were higher than those in the control group, with statistical significances (P＜0.05). The levels of IL-18, IL-6 and TNFα in the study group after treatment were lower than those in the control group, the differences were statistically significant (P＜0.05). There was no significant difference in the total incidence of adverse reactions between the two groups(P＞0.05). Conclusion Mesalamine combined with Tin Powder enema can enhance the clinical treatment effect in patients with UC, improve the immune function, reduce inflammation, and have varying degrees of impact on immune indicators and cytokines, and it is safer.

Key words： Mesalazine Tin Powder enema Ulcerative colitis Curative effect Immune function Cytokines

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	CAI Yi
	HE Mingjie
	LUO Peipei

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CAI Yi,HE Mingjie,LUO Peipei. Effect of Mesalamine combined with Tin Powder enema in the treatment of ulcerative colitis and its influence on the immune function and cytokines of patients[J]. 中国当代医药, 2022, 29(2): 60-64.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2022/V29/I2/60

[1]	Gajendran M，Loganathan P，Jimenez G，et al.A comprehensive review and update on ulcerative colitis[J].Dis Mon，2019，65（12）：100 851.
[2]	徐晓玲，柴海娜，孙超，等.扬州市初诊为溃疡性结肠炎患者的肠道菌群变化及意义[J].国际消化病杂志，2017，37（2）：117-119.
[3]	朱蕾蕾，李莉，顾志坚，等.基于数据挖掘的中医内服及灌肠治疗溃疡性结肠炎方药规律分析[J].上海中医药杂志，2019，53（7）：10-14.
[4]	黄良玖，刘日升，马婷.益生菌四联活菌片和美沙拉嗪治疗缓解期UC 的疗效观察[J].西南国防医药，2018，28（10）：70-72.
[5]	陈慕媛，李辉标，陈新林，等.锡类散对比美沙拉嗪治疗溃疡性结肠炎Meta 分析[J].辽宁中医杂志，2018，498（11）：32-36.
[6]	葛均波，徐永健-内科学[M].8 版.北京：人民卫生出版社，2013：385-390.
[7]	吴开春，梁洁，冉志华，等.炎症性肠病诊断与治疗的共识意见（2018年·北京）[J].中国实用内科杂志，2018，38（9）：26-43.
[8]	Turner D，Ruemmele FM，Orlanski-Meyer E，et al.Management of Paediatric Ulcerative Colitis，Part 1：Ambulatory Care-An Evidence-based Guideline From European Crohn′s and Colitis Organization and European Society of Paediatric Gastroenterology，Hepatology and Nutrition[J].J Pediatr Gastroenterol Nutr，2018，67（2）：257-291.
[9]	Singh S，Feuerstein JD，Binion DG，et al.AGA Technical Review on the Management of Mild-to-Moderate Ulcerative Colitis[J].Gastroenterology，2019，156（3）：769-808，e29.
[10]	陈浩，张波，徐速，等.甘草泻心汤联合美沙拉嗪对溃疡性结肠炎的疗效及对血清炎症指标的影响[J].中药材，2017，40（2）：475-478.
[11]	宋东旭，何洪芹，张文玲，等.糜蛋白酶联合锡类散对溃疡性结肠炎患者肠道菌群和细胞因子的影响[J].现代中西医结合杂志，2019，28（34）：74-78.
[12]	孟亚平.锡类散联合美沙拉嗪肠溶片保留灌肠治疗直肠型溃疡性结肠炎的疗效评估[J].山西医药杂志，2017，5（17）：99-101.
[13]	王教学，余森源，严和中，等.美沙拉嗪联合锡类散，黄连素及云南白药保留灌肠治疗轻中度E2型活动期溃疡性结肠炎疗效观察[J].临床军医杂志，2017，45（8）：793-795.
[14]	何元清，何子彬，张晗，等.美沙拉嗪联合康复新液保留灌肠治疗活动期溃疡性结肠炎的临床观察[J].中国药房，2017，28（29）：4133-4136.
[15]	易满，刘金辉，黄凤，等.凉血止痢汤与锡类散保留灌肠治疗溃疡性结肠炎的疗效对比[J].现代生物医学进展，2017，17（21）：4132-4134，4099.