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2018 Vol. 25, No. 16
Published: 2018-06-08
4
Clinical characteristics analysis of critical patients in obstetric department adm itted into the ICU after “universal two-child”policy
LAN Yun-ping;ZENG Fan;LIJia-jia;LEIYu;HUANG Xiao-bo
Objective
To analyze the clinical features of critical patients in obstetric department admitted into intensive care unit(ICU)after “universal two-child” policy.
Methods
From January 2016 to April 2017,61 critical patients in obstetric departmentadmitted into ICU were divided into the advanced age group (n=22)and non-advanced age group(n=39).The gestationalweeks,newborn weight,neonatal survival,frequency of cesarean section,postpartum hemorrhage,the cause of admission into ICU,APACHE IIscore,SOFA score,the treatment time in ICU,main treatmentmeasures in ICU,and hospitalization expenseswere compared between the two groups.
Results
The proportion of “two-child” in the advanced age group was higher than that of the non-advanced age group(P＜0.01).APACHE Ⅱ score in the advanced age group was significantly higher than that in the non-advanced age group with a statistical difference (P＜0.05).The treatment time in ICU in the advanced age group was longer(P＜0.01),and plasma exchange rate and hemodiafiltration rate were greatly higher than those in the non-advanced age group (P＜0.05,P＜0.01).There was no significant difference in the ventilator utilization between the two groups(P＞0.05).The incidence of postpartum hemorrhage in the advanced age group was obviously higher than that of the non-advanced age group,and plasma infusion volume of in the advanced age group wasmuch higher than that in the non-advanced age group with a statistical difference(P＜0.05).The hospitalization cost of the advanced age group was higher than that of the non-advanced age group with a significant difference(P＜0.05).
Conclusion
Compared with non-advanced age pregnant women,those in advanced age have a higher risk of critical diseases and postpartum hemorrhage,more use of plasma products,longer ICU stay,and moremedical costs.Early admission to ICU for supervision and treatment in these critically ill pregnant women can improve their clinical outcomes and reducemedical expenses.
2018 Vol. 25 (16): 4-7 [
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207
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8
Application of pulmonary function tests in patients w ith asthma COPD overlap syndrome and chronic obstructive pulmonary disease
LU Shu-biao;SHEN Shan-liang;LONG Zhao-hua;LIN Jing-song
Objective
To preliminarily describe the differences in the pulmonary function of patients with COPD,asthma-COPD overlap syndrome(ACOS),and to provide a basis for clinical treatment.
Methods
From December 2015 to December 2016,the First People′s Hospital of Shunde District and Chencun Hospital of the First People′s Hospital of Shunde Districtwere admitted to the outpatient department of 97 patients,themedical records for a series of all stable patients with persistent airflow limitation due to COPD or ACOS were retrospectively reviewed and divided into the COPD group (n=63),ofwhich included 26 patientswithmild tomoderate COPD and 37 patientswith severe COPD,the ACOS group (n=24).All the patients underwent pulmonary function tests,including FVC,FEV
1
,FEV
1
/FVC,PEF,MMEF,MVV,airway resistance.
Results
In pulmonary function,the study found that the PEF of patients in the ACOS group was lower than that of COPD in mild and moderate groups(P＜0.05),but the total respiratory impedance and central airway resistance in the ACOS group was higher than that of COPD patientswith mild tomoderate group(P＜0.01),while the rest the index was not statistically significant(P＞0.05).FVC,FEV
1
and FEV
1
/FVC was significantly higher in the ACOS group than that in the COPD severe group(P＜0.05);MMEF and MVV was significantly higher in the ACOSgroup than that in the COPD group(P＜0.01),but there were no significant differences in PEF and respiratory impedance(P＞0.05).PEF,the total respiratory impedance and central airway was higher in the ACOS group than that in the mild to moderate of COPD group (P＜0.05).While the other indexes were not statistically significant(P＞0.05).
Conclusion
There are differences in lung function between patients with ACOSand COPD,which provide the basis for clinical treatment.
2018 Vol. 25 (16): 8-11 [
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153
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12
Follow-up study of high frequency repetitive transcranialmagnetic stimulation on sustainability of the im provement role for negative sym ptom s in schizophrenic patients
CAIGuang-Chao;GUAN Yong;QIMing;LIZhao-Hui;WANG Jiang
Objective
To investigate the sustainability of high frequency repetitive transcranialmagnetic stimulation on sustainability of the improvement role for negative symptoms in schizophrenic patients with chronic course of disease.
Methods
From September 2015 to September 2016,40 patientswith negative symptoms of chronic schizophrenia hospitalized in Mental Hospital of Daxing District in Beijing City were selected.High frequency repetitive transcranialmagnetic stimulation was used for treatment.Data were collected before treatment,end of treatment,1,3months and 6months after treatment.Positive and negative symptom scale(PANSS)and side effects scale(TESS)were used to evaluate efficacy and side effects.
Results
The difference between the negative symptom scores and the total score data in the PANSS scale before treatment,at the end of treatment,1,3 months and 6months after treatmentwere statistically significant(F=45.621,57.369,P＜0.05).The results of q test showed that the values at the end of treatment and 1months after treatment were all lower than those before treatment,after the end of treatment 3,6months,the differenceswere statistically significant(P＜0.05).Before treatment,therewere 2 cases of"tremor"patients and 1 case of"cast"patients,there was no significant change in symptoms after treatment.Therewas no statistical significance in the difference of severity score data in the TESS scale of different time points(F=1.254,P＜0.05).
Conclusion
High frequency repetitive transcranialmagnetic stimulation treating schizophrenia can improve their clinical symptoms in the short term.In particular,the negative symptoms have been improved greatly,but the effect of the improvement will be gradually weakened due to the prolongation of the time,continuous treatment is recommended.
2018 Vol. 25 (16): 12-15 [
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158
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16
Effect of Shenkang Injection combined w ith BaiLing Capsules in the treatment of non-dialysis patientsw ith chronic renal disease
HUWen-xing ;LIU Min
Objective
To observe the effect of Shenkang Injection combined with BaiLing Capsules in the treatment of non-dialysis patientswith chronic renal disease.
Methods
A total of 66 non-dialysis patientswith chronic renal disease treated in our hospital from March 2014 to March 2016 were selected and all patients were divided into the treatment group and control group according to the random number tablemethod,there were 35 cases in the treatment group and 31 cases in the control group.All patients in two groups were given nutritional therapy,correction anemia and control hypertension and other complications.In addition,the treatment group was treated with Shenkang injection 100 ml ivgtt qd and Bailing Capsules 2.0 g tid.The changes of high sensitive C reactive protein(hs-CRP),interleukin 6(IL-6),tumor necrosis factor alpha(TNF-α),serum creatinine(SCr),Cystatin-C(Cys-C),urinary protein and urine red blood cellswere detected before and after 12 weeks of treatment in two groups.
Results
After 12 weeks of treatment,the levels of hs-CRP,IL-6 and TNF-α in the observation group were lower than those in the control group (P＜0.05).The renal function indexes(SCr and Cys-C)in theobservation groupwere lower than those in the controlgroup(P＜0.05).Theurineprotein and urineerythrocyte in the observation group were lower than those in the control group(P＜0.05).Before and after treatment,there was no significant difference in the above-mentioned indexes in the control group (P＞0.05).
Conclusion
Shenkang Injection combined with Bailing Capsule has positive effect on improving the condition and micro-inflammatory state of non-dialysis patientswith chronic renal disease.
2018 Vol. 25 (16): 16-18 [
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196
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19
Clinical effect observation of laparoscopic surgery combined w ith Gonadotropin-Releasing Hormone Agonist in the treatment of ovarian chocolate cystw ith infertility
BAN Qing-mei;CUIYan-ping;HU Qing-lan
Objective
To investigate the effect of laparoscopic surgery combined with Gonadotropin-Releasing Hormone Agonist(GnRHa)in the treatment of ovarian chocolate cystwith infertility.
Methods
A prospective study of 82 patients with ovarian chocolate cysts and infertility who were treated in our hospital from May 2016 to January 2017 wasmade.Allpatientswere randomly divided into the controlgroup(n=41,treatedwith laparoscopic surgery)and theobservation group(n=41,treated with laparoscopic surgery combined with GnRHa).The clinical effect,reproductive outcome,pre-and posttreatment hormone levels,changes in clinical symptom scores and adverse reactions were observed in the two groups.
Results
The total effective rate and pregnancy rate in phaseⅢ-Ⅳ of the observation group were higher than those of the controlgroup,with statistically significantdifferences(P＜0.05).Therewas no statistically significant difference between the two groups in pre-treatment hormone levels and symptom scores(P＞0.05),but the post-treatment clinical symptoms scoresof the two groupswere lower than those before treatmentwith statistically significantdifference(P＜0.05).The posttreatment symptom score of the observation group was lower than that of the control group,with statistically significant difference(P＜0.05).The post-treatment luteinizing hormone(LH)and follicle stimulating hormone(FSH)of two groups were higher than those before the treatment,with statistically significant difference(P＜0.05),and the level of post-treatment estradiol(E
2
)and progesterone(P)of two groupswere lower than before the treatment,with statistically significant difference (P＜0.05).The post-treatment LH and FSH of the observation group were higher than those of control group,and post-treatment E
2
and P levels of the observation group were lower than those of control group,both with statistically significant differences(P＜0.05).The adverse reactions of low estrogen level symptoms appeared in patients of the observation group after second medication but were well tolerated,and those with severe symptoms were relieved after treatment.
Conclusion
Application of combination of laparoscopic surgery and GnRHa in the treatment of ovarian chocolate cystwith infertility can improve the curative effect,the pregnancy rate and ovarian functions,and reduce the postoperative recurrence rate,which isworth promoting.
2018 Vol. 25 (16): 19-22 [
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159
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23
M ethod of Inductively Coup led Plasma M ass Spectrometry for detecting of 10 heavy metals and hazardous elements in Safflower from different habitats
JIGuo-li;LIU Bin
Objective
To establish method of Inductively Coupled Plasma Mass Spectrometry (ICP-MS)for dectecting content of 10 heavymetals(Pb,Cd,As,Hg,Cu,Cr,Mn,Co,Sb and Mo)and hazardous elements in Safflower.
Methods
Safflower from different habitats were selected.After nitric acid preprocessing,microwave digestion method was used to make samples.In this study,ICP-MSmethod was used for the determination the content of the 10 heavymetals of Pb,Cd,As,Hg,Cu,Cr,Mn,Co,Sb,Mo and hazardous elements in each samples from January to December,2017.
Results
The average recovery (n=6)of Pb,Cd,As,Hg,Cu,Cr,Mn,Co,Sb and Mo were 100.8%,98.7%,96.5%,94.8%,102.1%,101.4%,103.0%,99.2%,97.4%and 98.6%,the average recovery rate of 10 heavy metals was from 95.8%to 103.0%,the range was acceptable.The RSD of the precision testwere 0.4%,0.9%,0.7%,0.6%,0.2%,0.8%,0.9%,0.7%,0.6%and 0.5%respectively.And the RSD of repeatability test were 1.2%,1.6%,2.4%,2.7%,1.9%,0.8%,1.2%,1.8%,2.1%and 1.6%respectively.The content detection of 10 heavymetals detecting shown that content detection of Cd exceede the standard in part area of Henan,Sichuan and Zhejiang Province,and content detection of Cu exceede the standard in Jianyang City of Sichuan Province,Lijiang City of Yunnan Province and Tacheng City of Xinjiang Uygur Autonomous Region,and content detection of Mu exceede the standard in Changji City,Tacheng City,Hetian City and Hami City of Xinjiang Uygur Autonomous Region,content detection of Cr exceede the standard in Yanjing City of Henan Province,Cixi City of Zhejiang Province and Nantong City of Jiangsu Province.
Conclusion
ICP-MS used in this study is accurate and high sensitive,which can be used for detecting content of 10 heavymetals and hazardous elements and safety assessment in Safflower.
2018 Vol. 25 (16): 23-27 [
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166
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28
Progresses in the treatment of atrial fibrillation
WANG Yu-bing;YIN Yue-hui
Atrial fibrillation（AF）is one of themost common arrhythmias,whose prevalence is high in the population.AF not only causes heart failure,leads to systemic embolism and stroke,but also significantly increasesmorbidity and mortality and seriously impacts on people′s health.Therefore,prevention and treatment of AF have been widely concerned.Treatment of AF includes upstream treatment,treatment of acute AF,anticoagulant therapy,rate control,and rhythm control.In recent years,treatment of AF has had substantial developments and AFmanagement has gradually formed an integrated managementmode:patients and multidisciplinary AF medical teams participate together in the management.This review aims to discuss the current treatment status and progress of the treatment of AF.
2018 Vol. 25 (16): 28-31转35 [
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162
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The research progress of Tenofovir Disoproxil Fumarate related renal damage
LU Mei-ling;YANGQin
As a new nucleoside drug for chronic hepatitis B antiviral Treatment,Tenofovir Disoproxil Fumarate was officially listed in China in 2014.The side effects of renal damage have attracted more attention since itswide application.In this systematic review,side effects of Tenofovir Disoproxil Fumarate,the characteristics and mechanism of renal injury,the clinicalmanifestations,and the clinical treatmentwill bemainly discussed.
2018 Vol. 25 (16): 32-35 [
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186
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36
Research Progress of M itochondrial M orphological and function changes in Tumor
ZHENG Hong-yi;WU Xiong-jian;YANG Jian-fen;ZHANG Ke;LIU Yao
Mitochondria are the regulatory center for cellular energy metabolism,substance synthesis,and death.In the developmentand progression of tumor,mitochondria as an important regulator,have a significant impact on the biological behaviors including tumor proliferation,migration,differentiation,and invasion.To approach the changes ofmitochondrial morphology and function,as well as their regulatory mechanism in the development and progression of tumor,will undoubtedly be the key to usingmitochondria as a new generation of cancer therapeutic target.In this paper,the advances in the role ofmitochondria in tumor development and progression are reviewed,in an attempt to elucidate the close association between them.
2018 Vol. 25 (16): 36-40 [
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159
)
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41
Clinical effect of tension free hernia repair through transverse incision of lower abdomen in treatment of adult inguinal hernia
CAO Bin;FAN Zhi-yong;HUANGWen-huan
Objective
To investigate the clinical effect of tension-free hernia repair of the lower abdomen transverse incision and traditional open tension-free hernia repair in the treatment of adult inguinal hernia.
Methods
A total of 83 patients with inguinal hernia admitted to our hospital from January 2014 to December 2016 were selected as research objects,and were divided into control group(41 cases)and observation group(42 cases)by random number tablemethod.Patients in observation group were treated with tension-free hernioplasty of transverse incision of lower abdomen,while patients in control group were treated with traditional open tension-free hernioplasty,and the two groupswere recorded,including operation time,postoperative bleeding amount and hospitalization time.The postoperative wound healing of two groups of patientswas recorded.
Results
The operation time and hospitalization time of patients in the observation group were significantly shorter than those in the control group,and the postoperative bleeding volume was significantly reduced compared with that in the control group,the difference was statistical significance (P＜0.05).The healing rate of patients in the observation group was better than that of the control group,the difference was statistically significant(P＜0.05).
Conclusion
Tension-free hernioplasty of transverse incision in lower abdomen has less skin scar and less trauma,which can shorten the operation time and postoperative hospital stay,reduce postoperative bleeding,facilitate the postoperative incision recovery,and isworthy of clinical promotion.
2018 Vol. 25 (16): 41-43 [
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172
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44
The application study of tracheal intubation in poisoning patients given prehospital emergency
TANG Hai-yang;YE Yong;LONG Chun-xiang
Objective
To observe the clinical effect of emergency treatment of hospitalized tracheal intubation in poisoned patients.
Methods
Seventy-six cases of poisoning with respiratory failure or respiratory arrest admitted to our hospital from January 2011 to January 2013 were selected as research objects,among which,poisoning with respiratory failure or respiratory arrest admitted to our hospital from January 2011 to January 2012 were treated routinely(observation group),and patients in each group were treated by pre-hospital tracheal intubation from February 2012 to January 2013(treatment group),with 38 cases in each group.Observe and compare the curative effect and complications of two groups of subjects after treatment.
Results
The success rate of rescue in the treatment group was significantly higher than that in the observation group.The difference was statistically significant(P＜0.05).Sixmonths later,wemade a hospital return visit to two groups of patients.therewere 2 deaths among 18 surviving patients in the observation group and 2 deaths among 38 patients in the treatment group.Themortality rate of patients in the treatment group was 5.3%lower than that in the observation group(10.0%),and the differencewas statistically significant(P＜0.05).Complications such as bleeding in oral cavity and throat,airway obstruction and choking cough occurred in both groups.there were 5 complications in the observation group and 23 complications in the treatment group.the incidence of complications in the treatment group (13.2%)was significantly lower than that in the observation group (60.1%),and the difference was statistically significant(P＜0.05).
Conclusion
Performing on-site tracheal intubation treatment on poisoning patients with respiratory failure or respiratory arrest due to poisoning,canmaintain the effective ventilatorymaintenance.improve the success rate of prehospital resuscitation significantly,and reduce themortality and incidence of complications significantly Therefore,it isworth to extensively clinical application.
2018 Vol. 25 (16): 44-46 [
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163
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47
Research and application ofmodified water swallow test in stroke patients w ith dysphagia
WENShui-qun;DENGZhen-xing;XUQiu-ping;CHENJin-lian;LIANGHui-lan;DONGHong-ling;LIANGShao-ying
Objective
To analyze the effect ofmodified water swallow test in stroke patientswith dysphagia and to evaluate the clinical research value.
Methods
A total of 616 stroke patients with dysphagia admitted to our hospital from July 2016 to January 2018 were selected as research objects,and were divided into control group and experimental group by random number tablemethod,with 308 cases in each group.Two groups of patientswere examined by swallowing radiography,on the basis ofwhich,the patients in experimental group were tested by improved wa-Tian drinking water testmethod,and the patients in control group were tested by traditional wa-Tian drinking water testmethod.Comparative analysis of two groups of patients aspiration screening rate,drinking water quantity,drinking water time and other indicators.
Results
The amount of drinking water in the experimental group(19.5±3.2)mlwhich was less than that in the control group(28.5±2.3)ml,and the differencewas statistically significant(t=26.9890,P＜0.05).And the total drinking time(10.5±2.3)swas shorter than that of the control group([22.5±2.0])s,the difference was statistically significant(t=69.0953,P=0.0000＜0.05).The cough and choking rate and the incidence of aspiration pneumonia in experimental group were less than those in control group,and the difference was statistically significant(P＜0.05).The positive rate of aspiration and swallowing radiography in experimental group was higher than that in control group,and the negative rate of aspiration and swallowing radiography was lower than that in control group,the difference was statistically significant(P＜0.05).
Conclusion
Improved water swallow test increase the diagnosis for aspiration in screening acute stroke patients with dysphagia and maintain a stable swallowing function.Therefore,it is feasible to substitute the traditionalwater swallow testwithmodified one.
2018 Vol. 25 (16): 47-49 [
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538
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50
Effect of positional pad combined w ith locally-app lied aloe vera gel on preventing pressure sore during prone-position surgery
LIU Ting-jiao;LIXiao-qian;XIAO Hou-lan;LIXing-wang
Objective
To explore the clinical effect of local application of positional pad and aloe vera gel in the prevention of pressure sores in prone-position surgery.
Methods
A total of 120 patientswho underwent spinal prone position surgery in our hospital from February 2016 to June 2017 were selected and divided into control group and observation group according to different treatmentmethods,with 60 cases in each group.Patients in the control group were treated with body position pads,while patients in the observation group were treated with body position pads combined with local application of aloe gel,and the skin pressure and pressure ulcer incidence of the two groups were compared.
Results
The skin pressure of two groups of patients has obvions improvement wend.The incidence of difference skim compression in the observation group was lower than that of the control group 1 h after operation,and the difference was statistically significant(P＜0.05).There was no significant difference in the incidence of skin compression between the two groups 30min,24 h and 48 h after operation(P＞0.05).the skin pressure of the two groupswas lower than that of 30 min after 48 h operation (P＜0.05).The incidence rate of pressure sores in the observation group was 3.33%lower than that in the control group(13.33%(8/60),and the difference was statistically significant(χ
2
=3.927,P=0.048).
Conclusion
In the prone-position surgery,the position pad combined with local application of aloe vera gel can effectively prevent the occurrence of pressure sores and play a certain protection on the skin,which has a clinical application value.
2018 Vol. 25 (16): 50-52 [
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194
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53
Effect of app lication of flupentixol and melitracen tablets in ad juvant treatment of angina after coronary artery intervention
LIXing-zhou;JIANG Shou-tao;NIE Peng-fei
Objective
To investigate the effect of application of Flupentixol and Melitracen Tablets in the adjuvant treatment of angina after coronary artery intervention.
Methods
Fifty-six patients with angina pectoris after percutaneous coronary intervention from September 2015 to September 2017 in our hospital were selected and divided into study group and control group according to random number tablemethod,with 28 cases in each group.The control group was treated with conventional therapy,and the study group was treated with flupentixol and melitracen tablets on the basis of the control group,and the therapeutic effects of the two groups were compared.
Results
Before treatment,there was no significant difference between the two groups in treatment-related scores(P＞0.05).After treatment,the treatmentrelated scores of patients in the study group were significantly higher than those in the control group,and the difference was statistically significant(P＜0.05).The related scores of the two groups of patients after treatmentwere higher than those before treatment,and the difference was statistically significant(P＜0.05).The total effective rate of treatment in the study group was significantly higher than that in the control group(P＜0.05).There was no significant difference in the incidence of adverse reactions between the two groups after treatment(P＞0.05).
Conclusion
Application of Flupentixol and Melitracen Tablets achieves better effect in the adjuvant treatment of angina after coronary artery intervention,significantly improves angina symptoms and promotes quick recovery of the disease in patientswith high safety,which provides effective guarantee for the prognosis.
2018 Vol. 25 (16): 53-55 [
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170
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56
Com parison of TEP operation and Lichtenstein operation for elderly inguinal hernia
HUANG Li-zhe
Objective
To investigate the clinical effect of TEP operation and Lichtenstein operation for elderly inguinal hernia.
Methods
A total of 80 elderly patients with inguinal hernia admitted to our hospital from January 2016 to May 2017 were selected and randomly divided into control group and observation group,with 40 cases in each group.The control group was repaired by open lichten stein operation and the observation group by TEP operation.The operation time,the time of first ambulation after operation,the total hospital stay and postoperativewound pain,postoperative serum swelling,postoperative scrotal edema and other complications and recurrence were compared between the two groups.
Results
Therewas no significant difference in the operation time between the two groups(P＞0.05).The first time out of bed and total hospitalization time of patients in the observation group were shorter than those in the control group,the difference was statistically significant(P＜0.05).The intraoperative blood loss(12.5±4.48)ml in the observation group was significantly less than that in the control group(20.6±9.82)ml,and the difference was statistically significant(t=4.1640,P=0.000＜0.05).The incidence of postoperative complications in the observation group was significantly lower than that in the control group(P＜0.05).The recurrence rate of patients in the observation group was 0(0%),and that in the control group was 1 2.5%,and the patients were operated again.There was no significant difference between the two groups in terms of recurrence after 6months follow-up(P＞0.05).
Conclusion
Laparoscopic complete retroperitoneal hernia repair can shorten the hospitalization time and operation time and reduce intraoperative bleeding and postoperative pain and reduce postoperative complications and recurrence rate,compared with the high risk of lixinstern surgery,it can be focused on the clinical application.
2018 Vol. 25 (16): 56-58转62 [
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162
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59
Clinical effect of bone marrow combined w ith peripheral blood haploidentical hematopoietic stem cell transp lantation in the treatment of acute leukem ia
XU Xiao-li
Objective
To explore the clinical effect of bone marrow combined with peripheral blood haploid-matched hematopoietic stem cell transplantation in the treatment of acute leukemia.
Methods
Fifty-three patients with acute leukemia who underwent allogeneic hematopoietic stem cell transplantation in our hospital from January 2007 to January 2016 were retrospectively analyzed.According to different transplantation methods,they were divided into experimental group(22 cases)and control group(31cases).Patients in experimental group were treated with bonemarrow combined with peripheral blood haploid hematopoietic stem cell transplantation,patients in control group were treated with bonemarrow stem cell transplantation,and peripheral blood stem cells in the experimentweremobilized by G-CSF.The recovery of blood cells,incidence of acute graft-versus-host disease(aGVHD),transplantation-related mortality,2 years recurrence rate and survival rate and adverse reaction rate were compared between the two groups.
Results
The survival rate of patients in the experimental group was higher than that in the control group,while the recurrence rate and incidence rate of aGVHD were lower than that in the control group,the difference was statistically significant(P＜0.05).The blood routine indexes of patients in the experimental group after transplantation and follow-up were higher than those in the control group,and the differencewas statistically significant(P＜0.05).The incidence of adverse events in the experimental group was lower than that in the control group,and the difference was statistically significant(P＜0.05).
Conclusion
Bonemarrow combined with peripheral blood haploidentical hematopoietic stem cell transplantation is of great significance in the treatment of acute leukemia,and can reduce the recurrence rate and incidence of aGVHD on the basis of improving the quality of life.It isworth applying and popularizing.
2018 Vol. 25 (16): 59-62 [
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178
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63
The different of effects on annular hemorrhoids between PPH and M illigan-M organ
FU Yue-quan;ZHOU Jin-liang;HOU Hua-sen;LIN Jun-song;HUANG Yu-cong
Objective
To compare the different of effects on Annular hemorrhoids by PPH or Milligan-Morgan.Methods Sixty patientswith circular hemorrhoidswho were admitted to our hospital from June 2015 to September 2017 and were to be treated were selected as research objects,and were divided into control group and observation group by random number tablemethod,with 30 cases in each group.The control group was treated with Milligan-Morgan operation,while the observation group was treated with PPH operation.To evaluate the therapeutic effect of the two groups,and to evaluate the pain degree of the two groups after treatment(1,3 and 5 d)by visual analogue scale(VAS),at the same time,to compare the situation in treatment(intraoperative blood loss,operation duration)and postoperative complications.
Results
The cure rate of patients in the observation group was higher than that in the control group,and the difference was statistically significant(P＜0.05).On the first day after surgery,therewas no significant difference in VAS scores between the two groups(P＞0.05).On the 3
rd
and 5
th
day after operation,the VAS score of the observed patientswas significantly lower than that of the control group,and the difference was statistically significant(P＜0.05).The intraoperative blood loss in the observation group was significantly less than that in the control group,and the operation time was significantly shorter than that in the control group,the difference was statistically significant(P＜0.05).The incidence of postoperative complications in the observation group was significantly lower than that in the control group(P＜0.05).
Conclusion
The PPH has better advantage in efficacy,complications,and patients can have faster recovery and less pain than Milligan-Morgan surgery.
2018 Vol. 25 (16): 63-65 [
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66
Effect observation of keeping need le in different parts of hem ip legic patients by reverse venipuncture
CHEN Yin-yan MA Chun-yuan;HU Fei-e;HUANG Xiao-dan;LIANG Bi-jun;ZHONG Ming-li;HUANG Zhong-ru;YU Ju-an;HE Yan-fei
Objective
To study the effect of needle retention in hemiplegic patientswith different parts of venipuncture.
Methods
From July 2016 to December 2017,90 patientswith stroke hemiplegia treated in the Department of Neurology of our hospital were selected as the subject.According to the random digital tablemethod,they were divided into three groups:group A,B,C,with 30 cases in each group.The three groups underwent venipuncture by themethods of hand back forward puncture,hand back reverse puncture and forearm reverse puncture,respectively.The success rate of one puncture,72 hours of indwelling,pain degree of puncture site,patient satisfaction and adverse reaction were compared among the three groups.
Results
The success rate of single puncture in group B was higher than that in group C,the difference was statistically significant(P＜0.05),but there was no significant difference between group B and group A(P＞0.05).The retention rate for 72 hours and the degree of satisfactionin in group B was significantly higher than that in group A and group C.The incidence of adverse reactions and the pain score of puncture site in group B was lower than that in group A and group C(P＜0.05).
Conclusion
The success rate of reverse vein puncture on the back of hand is high,the retention time is long,the adverse reaction is less,the pain of puncture can be reduced,and the satisfaction of patients can be improved.
2018 Vol. 25 (16): 66-68 [
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170
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69
Clinical study of hard channelm inimally invasive puncture and drainage in the treatment of hypertensive intracerebral hemorrhage
CHEN Yuan-xin;HUANG Peng;ZUO Liang-cheng;MING Qiang
Objective
To investigate the efficacy ofminimally invasive puncture and drainage in the treatment of hypertensive intracerebral hemorrhage.
Methods
From January to December in 2017,64 cases of patients with hypertensive cerebral hemorrhage were selected as the subjects,and divided into observation group and control group by random number tablemethod,32 cases in each group.The patients were treated with conservative treatment.The patients in the observation group were treated by hard channelminimally invasive puncture drainage,and the control group was treated by craniotomy hematoma evacuation.The clinical efficacy,hematoma clearance rate,preoperative and postoperative neurological deficit score and postoperative complication rate of the two groupswere compared.
Results
After treatment,the total clinical effective rate in the observation group was 90.63%,significantly higher than the control group for 71.88%,the differencewas statistically significant(P＜0.05).Postoperative hematoma clearance rate in the observation group was significantly higher than that in the control group (P＜0.05).Postoperative neurological deficit score in the observation group of patientswas significantly lower than that in the control group (P＜0.05).The postoperative complication rate of the observation group was 6.25%,significantly lower than the control group of 31.25%,the difference was statistically significant(P＜0.05).
Conclusion
Hard channelminimally invasive puncture and drainage is effective in treating hypertensive intracerebral hemorrhage,with a thorough removal of hematoma,and can improve neurological function,reduce postoperative complication rate.Which isworth popularizing and applyingwidely.
2018 Vol. 25 (16): 69-71 [
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160
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72
Study of the influence of hyperuricem ia on IgA nephropathy
NILi
Objective
To understand the clinical indicators and pathological features of patients with IgA nephropathy and hyperuricemia,and to investigate the influence of hyperuricemia on IgA nephropathy.
Methods
A total of 125 patients with primary IgA nephropathy definitely diagnosed by pathological detection after renal biopsy who hospitalized in nephrology department of our hospital from March 2013 to June 2017 were enrolled.Among them,the ratio ofmale to female was 44 cases to 81 cases.According to the serum uric acid level,they were divided into the normal uric acid group (69 cases)and the hyperuricemia group (56 cases).The indexes of age,gender,serum uric acid,serum creatinine,24-hour urinary protein,serumalbumin,blood cholesterol,triglyceride and hemoglobin were recorded.All patients were performed with renal pathological examinations and Lee parallel grading.The clinical and pathological features of the two groups were statistically analyzed.
Results
The level of 24-hour urinary protein excretion,serum creatinine,triglyceride and total cholesterol in the hyperuricemia group were higher than those in the normal uric acid group (P＜0.05).The Lee grading of renal pathology in the hyperuricemia group wasworse than that in normal uric acid group(P＜0.05).
Conclusion
Patients with IgA nephropathy are likely to develop hyperuricemia.Compared with patients with normal serum uric acid,their clinical manifestations and renal pathological injury are more serious,suggesting that hyperuricemia is associated with the prognosis of IgA nephropathy and should be paid great attention and provided with effective treatment as an intervention in time.
2018 Vol. 25 (16): 72-74 [
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189
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75
Clinical effect analysis of flexible ureteroscope combined w ith extracorporeal shock wave lithotripsy in the treatment of renal calculi
YUEWei-wei;XIE Jin-dong;CHEN Jing-yu
Objective
To study the effect of flexible ureteroscope combined with extracorporeal shock wave lithotripsy in the treatment of renal calculi.
Methods
A total of 120 cases of renal calculi from February 2015 to February 2017 in our hospital were selected and randomly divided into the observation group and the control group,60 cases in each group.The observation group was treated with flexible ureteroscope and extracorporeal shock wave lithotripsy,and the control group was treated with routine treatment,and the therapeutic effect of the two groups was compared.
Results
After treatment,the gravelsuccess rate of the observation group was81.67%,whichwas higher than 65%in the controlgroup,the difference was statistically significant(P＜0.05).In the observation group,the total clearance rate was 96.67%,which was higher than 56.67%in the control group,the difference was statistically significant(P＜0.05).The incidence rate of complication in the observation group was lower than that in the control group,the difference was statistically significant(P＜0.05).The operation time of the observation group was(82.41±9.63)min,which was lower than(95.68±12.49)min of the control group,the difference was statistically significant(P＜0.05).
Conclusion
The effect of combination of flexible ureteroscope and extracorporeal shock wave lithotripsy in the treatment of renal calculi is significant,safe and feasible,which not only shortens the operation time of patients,but also improve the success rate of crushed stone crushing,avoid the adverse reaction of the patients,and have high recovery value for the patients.
2018 Vol. 25 (16): 75-77 [
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138
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78
Analysis of risk factors of nosocom ial infection secondary to urem ia
CHEN Zhi-peng;SHENMei-fang;CHEN Dong
Objective
To analyze and explore the risk factors of secondary nosocomial infection in uremia and to provide reference for clinical treatment and nursing of uremia.
Methods
The clinical data of 184 uremic patients treated in our hospital from December 2014 to October 2017 were retrospectively analyzed.According to whether hospital infection occurred,all the patientswere divided into the infection group(n=92)and the non-infection group(n=92).And the clinical symptoms and signs of the two groups of patientswere analyzed and compared.Logistic regression was used to analyze the risk factors of nosocomial infection secondary to uremia.
Results
A total of 184 cases of uremic patients sent samples 243 cases,the positive detection rate was 67.08%.Pathogenic bacteria were mainly Klebsiella pneumoniae(31.90%),Pseudomonas aeruginosa(26.38%)and Escherichia coli(15.34%).Secondly,Logistic regression analysis showed that age,presence of dialysis,hyperglycemia,high serum creatinine and high serum albumin were the risk factors of secondary nosocomial infections in uremic patients(OR＞1,P＜0.05).BMI≥24 kg/m
2
was the protective factor of secondary nosocomial infection in uremic patients(OR＜1,P＜0.05).
Conclusion
Secondary nosocomial infections in uremia are affected bymany factors.It is suggested that targeted interventions should bemade according to the above risk factors and protective factors so as to reduce the incidence of infection.
2018 Vol. 25 (16): 78-80 [
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157
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81
Effect observation of 1470 nm laser vaporization prostatectom y and transurethral resection prostate in the treatment of benign prostatic hyperp lasia
TAN Jian-qiu1CHENGWei-wen;WU Ying-hong;ZHONG Hui-yuan;RUAN Yong-tong;CHEN Guang-yao
Objective
To observe the effect of 1470 nm laser vaporization prostatectomy and transurethral resection of prostate in the treatment of benign prostatic hyperplasia (BPH).
Methods
A total of 106 BPH patients treated in our hospital from October 1,2016 to October 5,2017 were enrolled in this study.By computer randomization,they were evenly divided into the observation group and the control group,53 cases in each group.Patients in the observation group were treated by 1470 nm laser vaporization prostatectomy,while in the control group,transurethral resection of the prostate was performed.The postoperative effect was compared between the two groups.
Results
The total effectiveness rate was 96.23%in the observation group,which was higher than that in the control group accounting for 84.91%,with significant difference (P＜0.05).The retention time of catheter and hospital stay in the observation group were shorter than those in the control group,the level of postoperative hemoglobin after surgery,the incidence of complications in the observation group were lower than those in the control group,with significant difference (P＜0.05).
Conclusion
1470 nm laser vaporization prostatectomy can obtain a remarkable effect on treating BPH with a variety of advantages,which is worthy of promotion and application.
2018 Vol. 25 (16): 81-83 [
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161
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84
Effect of percutaneous nephrolithotom y in the treatment of kidney stones after failed extracorporeal shock wave lithotripsy
YANG Yue
Objective
To investigate the effect of percutaneous nephrolithotomy in the treatment of kidney stones after failed extracorporeal shock wave lithotripsy.
Methods
A total of 82 cases of kidney stones after failed extracorporeal shock wave lithotripsy who were admitted to the department of urology in our hospital from January to December in 2017 were selected and randomly divided into the control group and the observation group,41 cases in each group.The control group was given extracorporeal shock wave lithotripsy treatment,and the observation group was given percutaneous nephrolithotomy.The effectswas compared between the two groups.
Results
The stone removal time and operation time in the observation group were longer than those in the control group,with significant difference(P＜0.05).There was no significant difference in the length of hospital stay between the two groups (P＞0.05).The rate of stone clearance in the observation group was 97.6%(40/41),which was significantly higher than that of 63.4%(26/41)in the control group,the differencewas statistically significant(P＜0.05).After treatment,the levels of BUN and Cr in the two groupswere lower than those before treatment,and the levels of BUN and Cr in the observation group after treatment were lower than those in the control group,with significant difference (P＜0.05).The incidence rate of complication in the observation group was 4.9%,which was significantly lower than that of 19.5%in the control group,and there was statistically significant difference (P＜0.05).
Conclusion
For the cases of clinically treated kidney stones after failed extracorporeal shock wave lithotripsy,percutaneous nephrolithotomy has a higher level of stone clearance rate,the safety is ideal,and the renal function has a significant improvement effect.It isworthy of clinical promotion and application.
2018 Vol. 25 (16): 84-86 [
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171
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87
Discussion on the effectiveness of app lication of 3D printing technology in surgerical treatment of calcaneal fractures
XIONGMin-jian;TANG Li-ying;ZHU Xin-yang;MO Shi-fen;XU Ya-fei
Objective
To explore the effectiveness of application of 3D printing technology in surgical treatment of calcaneal fractures.
Methods
Altogether 60 cases of calcaneal fractures who were treated in our hospital from February 2014 to February 2017 were reviewed and analyzed.They were divided into the control group and the experiment group by difference surgerymethod,30 cases in each group.Two groups of patientswere treated with open reduction and internal fixation.The control group underwent surgery according to CT (computerized tomography)two-dimensional image and X-ray image.The experiment group was treated with surgery by 3D printing technique after the pre-shaping of the steel plate.The difference in the outcome of the patients with calcaneal fracture were compared between two groups.
Results
The duration of surgery and intraoperative hemorrhage of experiment group were significantly shorter than those of the control group (P＜0.05).The excellent treatment rate of experiment group (90.00%)was significantly higher than that of the control group(66.67%),and the X-ray exposure probability of the C-arm was significantly lower than that of the control group(P＜0.05).The incidence of complications between two groups had no statistically significant difference(P＞0.05).
Conclusion
With application of 3D printing technique in surgical treatment of calcaneal fractures,the presurgical design and simulation of the operation can be performed,which improves the effect of operation,reduces the probability of complications and has clinical significance.
2018 Vol. 25 (16): 87-89 [
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136
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90
Effects of modified interosseous dorsal artery free perforator flaps in repair of hand palmar soft tissue defect
ZHENG Zuo-hui;TAN Zhi-wei;XIAO Zhi-lin;ZHENG Yong-cai;LUO Huan-ming;LIANG Xiao-lan;FENG Jing-wang
Objective
To study the clinical effects ofmodified interosseous dorsal artery free perforator flaps in the repair of soft tissue defect of hand palm and its influence on postoperative sensory function and appearancemorphology.
Methods
A total of 30 cases of patients with soft tissue defect of hand palm admitted to our hospital from January to December 2017 were selected for the study subjects and were divided into themodified group (n=15)and the routine group (n=15)according to system randomization method.The modified group was given modified interosseous dorsal artery free perforator flaps repair,and the routine group was given interosseous dorsal artery free perforator flaps repair.The surgical effects were compared between the two groups.
Results
The intraoperative blood loss and hospital stay in themodified group were lower than those in the routine group(P＜0.05).The scores of postoperative pain，temperature sensation and touch pressure sensation were higher than those in the routine group(P＜0.05),while the two-point resolution distance was lower than that in the routine group(P＜0.05),and the scores of appearance and VASwere higher than those in the routine group(P＜0.05),while the postoperative complicationswere lower than those in the routine group,the differences were statistically significant(P＜0.05).
Conclusion
Modified interosseous dorsal artery free perforator flaps can have good effects in the repair the soft tissue defects of the hand palm,and it can not only effectively reduce the postoperative complications and promote patient rehabilitation,but also improve the sensory function recovery and postoperative esthetic effect.
2018 Vol. 25 (16): 90-92 [
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141
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93
The clinical effect of arthroscopy assisted reduction and internal fixation combined w ith continuous passive movement in the treatment of tibial p lateau fracture
CHEN Kang-yao;GU En-yi;ZHENG Zhong
Objective
To investigate the clinical effect of arthroscopic internal fixation combined with continuous passivemovement(CPM)in the treatment of tibial plateau fracture.
Methods
A total of 80 patientswith tibial plateau fracture in our hospital from November 2015 to August 2017 were studied and grouped according to the random number tablemethod.In the control group,40 patientswere treated with arthroscopic assisted reduction and internal fixation,and the regular active knee exercise training was performed after operation.A total of 40 patients in the observation group were combined with continuous passivemotion after operation.The difference of clinical efficacy between the two groups was compared after 12 weeks.
Results
After 2 and 12 weeks,knee extensor activity,knee activity of observation group were higher than that of control group,the difference was statistically significant(P＜0.05);12 weeks after the operation,the total score of Rasmussen in the observation group was 97.50%(39/40),which was higher than that in the control group(77.50%[31/40]),and the difference was statistically significant(P＜0.05).
Conclusion
Arthroscopy assisted reduction and internal fixation combined with CPM in the treatment of tibial plateau fractures has a significant effect,which can promote the recovery of the knee joint function,and it isworth popularizing.
2018 Vol. 25 (16): 93-95 [
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169
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96
Efficacy and safety of proximal femur anti-rotation intramedullary nail in the treatment of elderly patientsw ith intertrochanteric fractures
SONG Zhi-hui;CHEN Jin;XIONG Shu-hong;CHEN Si;YUAN Jian-bing;MA Jun-chang
Objective
To investigate the clinical effect of proximal femur anti-rotation nail in the treatment of elderly intertrochanteric fractures.
Methods
A total of 60 elderly patientswith intertrochanteric fractures treated in our hospital from August 2012 to August 2017 were selected as research subjects.According to different treatment methods,they were divided into control group(n=25)and observation group(n=35).In the control group,dynamic hip screw was used，while in the observation group,proximal femur anti-rotation intramedullary nail was adopted.The clinical indexes and therapeutic effect of the two groups were compared.
Results
The excellent and good rate was 91.4%in the observation group,which was higher than that in the control group accounting for 68.0%,with statistical difference(P＜0.05).The incidence of complications in the observation group was lower than that in the control group,with significant difference(P＜0.05).The operation time,healing time and hospital stay in the observation group were shorter than those in the control group,intraoperative blood loss was lesser than those in the control group,which were displayed statistical significance(P＜0.05).
Conclusion
The proximal femur anti-rotation intramedullary nail obtains a good effect on intertrochanteric fractures in the elderly in high safety and it isworthy of promotion and application.
2018 Vol. 25 (16): 96-98 [
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164
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99
Evaluation of the effect of artificial knee joint replacement on severe degenerative joint degenerative knee joint
XING Shu-zhong
Objective
To evaluate the effect of artificial knee joint replacement in the treatment of severe degenerative joint degenerative knee disease.
Methods
A total of 85 patients with degenerative knee joint degenerative joint disease whowere admitted to our hospital from January 2014 to December 2017 were enrolled in this study.All patients underwent knee arthroplasty.The time of operation，the amount of bleeding,the amount of postoperative drainage,the therapeutic effect and the incidence of complications were analyzed.The scores of knee injury（HSS),pain scor（VAS),score of joint activity（ROM)quality of life score,mental status improvement score were compared.
Results
The duration of operation was(79.68±10.28)min,the blood loss was(80.52±18.68)ml and the postoperative drainage volume was(459.62±69.88)ml.The total effective rate was 95.29%after treatment.The incidence of complications was 2.35%.After treatment,HSS score,ROM score,physical function,mental function,social function and physical life were higher than those before treatment and after treatment.SAS,SDS and VAS scores were lower than before treatment,the differences were statistically significant(P＜0.05).
Conclusion
The effect of artificial knee joint replacement in treatment of severe degenerative joint degenerative knee joint is significant,which isworthy of clinical reference and promotion.
2018 Vol. 25 (16): 99-101 [
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165
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102
Effect com parison of platelet-rich p lasma and sodium hyaluronate in the treatment of knee osteoarthritis
CUIGui-hua
Objective
To compare the clinical effects of platelet-rich plasma(PRP)and sodium hyaluronate(SH)in the treatmentof knee osteoarthritis.
Methods
A total of 80 patientswith knee osteoarthritiswhowere hospitalized in our hospital from March 2016 toMay 2017were divided into PRPgroup and SH group according to random number table,40 cases in each group.PRP group was injected with PRP in the joint cavity,and the SH group was treated with SH in the joint cavity.Theywere performed once aweek for 5 times.Both groupswere provided with wax,microwave,and ultrasound therapies.Thewestern ontario andmcmaster universities osteoarthritis index scale(WOMAC)and visual analogue scale(VAS)were evaluated for effects before treatment,just after therapy,and 3 and 6months after treatment during follow up visits.The radiographic results of knee joints using magnetic resonance imaging were compared before and 6 months after treatment.
Results
TheWOMAC score and VASscorewere significantly lower in the two groups after treatment than those before treatment(P＜0.05).Thescores in the PRPgroupwas lower than those in the SH group justafter therapy,3 and 6months after treatment,with statistical differences(P＜0.05).The improvement rate in the PRP group was better than that in the SH group aftermagnetic resonance imaging detection,with a significant difference(P＜0.05).
Conclusion
Both PRP and SH are effective in the treatment of knee osteoarthritis,and the effect in the PRP ismore remarkable.
2018 Vol. 25 (16): 102-104转117 [
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158
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105
Analysis of risk factors of enterocolitis after congenitalmegacolonectom y
MOYou-lian;HUXiao-hua;CHENMao-fang;DUANLi-feng;SU Jia-hong;ZHANGPing-feng;ZHONGChen
Objective
To study the risk factors of enterocolitis after congenitalmegacolonectomy.
Methods
The subjects selected for this study were 140 patientswith congenital Hirschsprung′s disease who had undergone surgery in our hospital from January 2013 to December 2017.They were divided the observation group(n=46)and the control group(n=94)by patients complicated or uncomplicated postoperative concurrent enterocolitis.Explore related risk factors.
Results
Preoperative suffering from enteritis,suffering from upper respiratory tract or lung infection,malnutrition and postoperative anastomotic leakage or stenosis,intestinal obstruction and other complications,resection of rectalmucosa and internal sphincterwere congenitalmegacolon after enterocolitis single factor in patients;multiple factors include preoperative bowel inflammation,upper airway or lung infection,malnutrition.The differences in age，surgical age,lesion type,surgical method,and surgical resection range of the two groupswere relatively poor,the difference had no statistical significance(P＞0.05).
Conclusion
The risk factors for enterocolitis after congenitalmegacolon surgery include preoperative conditions，nutritional status,removal of rectalmucosa and internal sphincter is an effective measure to avoid postoperative colitis.
2018 Vol. 25 (16): 105-107 [
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165
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108
Expression and clinical significance of MMP-9 and TSP-1 in chorionic and decidual tissues in m issed abortion patientsw ith subclinical hypothyroidism
WEN Li;YANG Xiao-yan;ZHANG Gui-li;ZHANG Han-ying
Objective
To investigate the expression and clinical significance ofmatrixmetalloproteinase-9(MMP-9)and thrombospondin-1(TSP-1)in chorionic and decidual tissues inmissed abortion patientswith subclinical hypothyroidism.
Methods
25 cases ofmissed abortion patientswith subclinical hypothyroidism treated in Department of Obstetrics and Gynecology clinic of our hospital from July 2016 to July 2017 were selected in the study group,and other 25 cases of early pregnant patients for voluntary induced abortion at the same period in our hospital were enrolled in the control group.The clinical data of two groupswere retrospectively analyzed,and the MMP-9 positive expression in chorionic and decidual tissues and the integral optical density(IOD)in TSP-1 positive region were compared between the two groups.
Results
The MMP-9 positive expression rate in the chorionic and decidual tissues in the study group was lower than that in the control group,while the IOD value in TSP-1 positive region was higher than that in the control group,the differenceswere statistically significant(P＜0.05).
Conclusion
Inmissed abortion patientswith subclinical hypothyroidism,the expression of MMP-9 in chorionic and decidual tissues decreases significantly while the expression of TSP-1 increases significantly.The above two indexes can inhibit the neovascularization,reduce the invasiveness of trophoblasts and affect the embryo implantation,leading to the occurrence ofmissed abortion.
2018 Vol. 25 (16): 108-110 [
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Analysis of the outcome of vaginal delivery of scar
BAIZhi;LONG Da-jian;CHIHao;YANGMing;CHEN Min-hong;LIU Zhuan-qin;HE Ya-ting;JIYan-jie
Objective
To analyze of the outcome vaginal delivery in the pregruant patients with scarred uteres.From June 2015 to June 2016,228 cases of vaginal delivery with second pregnancy admitted to our hospitalwere researched,they randomly divided into two groups,114casec in each group.With trail production condition was grouped research group vaginal delivery,without trail production condition was grouped control group by re-cesarean section.The amount of bleeding 24 h after delivery in the research group was lesser than that in the control group (P＜0.05),delivery time,hospitalization time in the research group was shorter than that in the control group(P＜0.05),incidence of adverse reaction in the research group was lower than that in the control group,the differenceswere statistically significant(P＜0.05).The neonatal Apger scores had no stistically significant between two groups(P＞0.05).
Conclusion
Scarred uterua is not the absolute incication for repeated cesarean section.those who meet requirement of vaginal delivery and do not have any clear incication for cesarean can have a vaginal birth after cesarean under intensive care.
2018 Vol. 25 (16): 111-113 [
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180
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114
Effect of Goserelin and M ifepristone in treatment of chocolate cyst by laparoscopy
WEILi-fen
Objective
To explore the clinical effect of laparoscopic surgery combined with Goserelin and Mifepristonein treatment of chocolate cyst of the ovary.
Methods
From March 2013 to March 2015,88 patientswith chocolate cystwere randomly divided into Goserelin group and Mifepristone group,44 cases in each group.All the cases in the two groups were treated by laparoscopic surgery,then the patients in Goserelin group were treated by Gestrinone,the patients in Mifepristone group were treated by Mifepristone.The serum levels of follicle stimulating hormone(FSH),luteinizing hormone(LH)and estradiol(E
2
)before and after therapy,the clinical effects,symptom improvement,infertility rate,recurrence rates,and pregnancy rates of the two groups were compared.
Results
There was no statistically significant difference in the levels of serum FSH,LH before and after treatment between the two groups(P＞0.05).Therewas no statistically significant difference in the levels of serum E
2
before treatment,but the levels of serum E
2
level in Goserelin group was statistically significantly lower than that in Mifepristone group(P＜0.05),after treatment,the clinical symptoms such as algopareunia and dysmenorrhea improved obviously after treatment in the two groups,but there was no statistically significant difference in the improvement between the two groups.There was no significant difference in the infertility rate between the two groups before treatment(P＞0.05).The total effective rates,recurrence rates,and pregnancy rates were 90.9%,11.4%,62.5%in Goserelin group and 77.3%,27.3%,43.5%in Mifepristone group,respectively,there were statistically significant differences between the two groups(P＜0.05).
Conclusion
There are somany advantages to treat chocolate cystwith laparoscopic surgery combined with Goserelin,such as significant clinical effect and low recurrence rate.It isworthy for extending in clinic.
2018 Vol. 25 (16): 114-117 [
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196
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118
The effect of sim p le gasbag for lateral perineal incision combined w ith deep laceration of vagina
LIU Yin-chun;ZHU Li-ying;CHENG Su-fang;XIE Xuan;OUYANGWen-qiong
Objective
To investigate the application value of simple gasbag in the suture process of perineum side cut with deep laceration of vagina.
Methods
Eighty-three puerperants of vaginal delivery（erineum side cut and deep laceration of vagina）in our hospital from July 2016 to December 2017 were selected and randomly divided into the observation group(conventional perineal suture combined with simple balloon,43 cases)and control group(conventional perineorrhaphy,40 cases).Surgery situation,postoperative pain,incision healing and other indicatorswere observed.
Results
In the observation group，the suture time,the average pain score of wound,infection rate of wound and resuture rate were(14.22±2.64)min,(4.72±0.95)point,4.6%,and 7.0%,respectively,which were all significantly lesser than those of the control group(P＜0.05),(18.09±1.23)min,(6.88±0.63)point,20.0%and 22.5%,respectively.Grade A healing rate in the observation group(86.0%)was significantly better than that in the control group(65.0%),the difference was statistically significant(P＜0.05).
Conclusion
The simple gasbag can reduce the pain of the mother,improve the speed of suture，avoid re suture and improve the healing of the wound in puerperants of vaginal delivery (perineum side cut and deep laceration of vagina).
2018 Vol. 25 (16): 118-120 [
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138
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121
Therapeutic value of uterine B-Lynch suture for postpartum hemorrhage in cesarean section
ZHAO Jing
Objective
To investigate the therapeutic value of B-Lynch suture in the treatment of postpartum hemorrhage in cesarean section.
Methods
From May 2016 to May 2017,100 puerperae suffering from a large volume of bleeding during cesarean section in our departmentwere selected as research subjects.They were divided into research group and control group by a random number tablemethod,50 cases in each group.In the research group,uterine B-Lynch suture was used,while in the control group,conventional hemostasis was adopted.The operative time，intraoperative blood loss,24 h total postpartum hemorrhage,and total effectiveness rate by cesarean section for stanching bleeding were compared between the two groups.
Results
The operative time was shorter than that in the control group,and the blood loss during the operation and the total blood loss at 24 hour after delivery were,lesser than those in the control group(P＜0.05).The total effectiveness rate by cesarean section for hemostasis in the research group was higher than that in the control group with a statistical difference(P＜0.05).
Conclusion
For cesarean section patients with postpartum hemorrhage,BLynch suture can shorten the operation time,reduce intraoperative blood loss and total bleeding 24 h after delivery,and effectively increase the total effectiveness rate of hemostasis.
2018 Vol. 25 (16): 121-123 [
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Analysis on the results of genetic diagnosis of 82 cases of thalassem ia in prenatal screening in Guizhou
WU Sha-sha;HE Zhi-xu;JIN Jiao;HUANG Jing;YUAN Jun
Objective
To understand the types of thalassemia genemutations in the couples during pregnancy and their fetuses in Guizhou Region and to provide reference data for the genetic consultation of thalassemia in our province.
Methods
Data were collected on the patientswhowere given prenatal diagnosis of thalassemia in the Prenatal Diagnosis Center of the Affiliated Hospital of Guizhou Medical University and Guizhou People′s Hospital from October 2012 to October 2014.Screening was performed by routine blood test and hemoglobin electrophoresis test,and the genotyping of thalassemia was performed by RDB and PCR.
Results
①In the data of 82 patients,26 cases ofα-thalassemia were detected,accounting for 31.7%.Themost common deletion type-α thalassemia in the Chinese people(-SEA,α3.7,α4.2)was detected;56 cases ofβ-thalassemia were detected，accounting for 68.3%.The seven genetic types ofmutations that were common in the Chinese people were detected,with themost common types of CD17(A→T),CD41-42(-TCTT),and IVS-2-654(C→T).②There were 51 coupleswho both carried α-thalassemia orβ-thalassemia according to the genetic diagnosis.Prenatal genetic diagnosis was carried out by collecting cord blood or amniotic fluid.There were 33 cases of fetuseswith prenatal diagnosis ofmild thalassaemia,10 cases of fetuseswith negative thalassemia,and 8 cases of fetuses with moderate to severe thalassemia.Among them,there were 5 cases of fetuses with severeβ-thalassemia according to the prenatal diagnosis.One case of fetus was bart′s edema,and two cases of fetuses had hemoglobin H disease.All of them were given themeasures to terminate the pregnancy.
Conclusion
There is a significant difference in the incidence rate of thalassemia.However,there are similar trends in the rates of genemutation.Among them,the detection rate ofβthalassemia carriers is significantly higher than that ofα-thalassemia carriers;through prenatal screening,the birth of the infantswith severe and intermediate thalassaemia can be avoided.
2018 Vol. 25 (16): 124-126 [
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156
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Effect of M ethylphenidate Hydrochloride Tablets in the treatment of ADHD in Children
OU Jian-kun;XU Yan
objective
To explore the effect of Methylphenidate Hydrochloride Tablets in the treatment of childhood hyperactivity.
Methods
A total of 100 children with ADHD admitted in our hospital from June 2015 to June 2017 were divided into two groups according to different treatmentmethods,the control group was treated with EEG biofeedback plus sensory training,on this basis,the observation group supplemented with Methylphenidate Hydrochloride Tablets（Ritalin),the clinical curative effect,symptoms improvement,cognitive function,and adverse drug reactions were compared between the two groups.
Results
The effective rate of observation group was 96%,which was significantly higher than 78%in the control group(P＜0.05).Group learning factor,behavior factor,after treatment hyperactivity factor,anxiety factor and impulse factor,physical and mental factor Cormer rating scale significantly reduced than that in the control group(P＜0.05);After treatment,the scores of the C-WISC scalewere significantly higher than those in the control group，with statistically significant difference（P＜0.05）.The incidence of dizziness,loss of appetite,difficulty in falling asleep and abdominal pain was slightly higher in the observation group than that in the control group,but the difference was not significant(P＞0.05).
Conclusion
Methylphenidate Hydrochloride Tablets treatment has a significant effect on children with ADHD.It can effectively improve the patient′s somatic symptoms,improve cognitive function,and have a positive d clinical significance.
2018 Vol. 25 (16): 127-129 [
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156
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130
Clinical effect observation of hysteroscopic resection and curettage in the treatment of endometrial polyps patients
ZHU Li;LIU qin
Objective
To investigate the clinical effect of hysteroscopic resection and curettage in the treatment of endometrial polyps infertility.
Methods
From February 2015 to November 2016,88 cases of endometrial polyps infertility were selected and randomly divided into groups.Curettage group was treated curettage and hysteroscopy,hysteroscopic resection group was treated undergoing hysteroscopic resection.The clinical efficacy of the two groups of endometrial polyps infertility,the total amount of bleeding during surgery,the time of operation,before and after intervention of quality of life SF-36 scale score,within one year of recurrence and pregnancy rate were compared between two groups.
Results
The clinical effect of hysteroscopic resection group was higher than that in the curettage group(P＜0.05).The total amount of hemorrhage in the hysteroscopic resection group was lesser than that in the control group,and the completion timewas shorter than that in the curettage group,the differenceswere statistically significant(P＜0.05).The SF-36 scores of the two groups before the intervention the difference had no statistical significance (P＞0.05).Quality of life SF-36 scale score of hysteroscopic resection group was superior to curettage group(P＜0.05).Hysteroscopic resection group 1 year recurrence rate was lower than that in the curettage group,1 year pregnancy rate was higher than that in the curettage group,the differences were statistically significant (P＜0.05).
Conclusion
Hysteroscopic resection of endometrial polyps in patients with infertility clinical effect is exact,and compared with curettage reduce the recurrence rate and better quality of life,and less trauma,can reduce bleeding and shorten the operation time,improve the pregnancy rate.
2018 Vol. 25 (16): 130-132 [
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141
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133
Clinical effect observation of Gangliosides in children with viral encephalitis
LIANG Yue
Objective
To explore the clinical efficacy of Gangliosides in children with viral encephalitis.
Methods
A total of 60 children with viral encephalitis treated from January 2012 to December 2017 in our hospitalwere selected.The subjects were divided into two groups according to the registration number,30 cases in each group.The control group took the conventional therapy;the study group took the gangliosides.The disappearance time and improvement time of clinical symptoms,clinical effect and NHP (Nottingham Health Profile)points were compared.
Results
The disappearance time and improvement time of clinical symptoms for study group were significantly shorter than that in the control group (P＜0.05);the total effective rate for study group (90.00%)was significantly higher than that in the control group(63.33%)(P＜0.05);the adverse event rate and recurrence rate for study group (10.00%,3.33%)were significantly lower than that in the control group(36.67%,16.67%)(P＜0.05);the NHP points for study group were significantly better than that for control group,the differenceswere statistically significant(P＜0.05).
Conclusion
For children with viral encephalitis,the Gangliosides can greatly improve the clinical symptoms and life quality,relieve the pain and reduce the recurrence rate.
2018 Vol. 25 (16): 133-135转138 [
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148
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136
Effect of Kuntai Capsule on perimenopausal syndrome and its influence on ovarian function
LIJie-lan;PAN Xiu-ting
Objective
To observe the effect of Kuntai Capsule in the treatment of perimenopausal syndrome and its influence on ovarian function.
Methods
Eighty patientswith perimenopausal syndrome admitted to our hospital from July 2015 to June 2017 were randomly divided into observation group and control groups,40 cases in each group.Patients in the observation group were treated with Kuntai Capsules,and those in the control group were treated with routinemedications.
Results
In the experimental group,the follicle-stimulating hormone(FSH)was(40.46±10.32)IU/L and estradiol(E2)was(25.95±8.55)pmol/ml,which were displayed statistical differences compared with the control group(P＜0.05).The total effectiveness rate in the observation group was 90.00%,higher than that in the control group(P＜0.05).The incidence of adverse reactions in the perimenopausal syndrome patients in the observation group was 10.00%,lower than that in the control group(P＜0.05).The symptom improvement time and hospital stay were(7.21±1.24)d and(20.15±2.45)d,shorter than those in the control group,the differenceswere statistically significant(P＜0.05).
Conclusion
The implementation of Kuntai Capsules in patients with perimenopausal syndrome can improve the ovarian function,enhance the treatment effect,and promote patient′s recovery.
2018 Vol. 25 (16): 136-138 [
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163
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139
The diagnostic value of high-frequency ultrasound in the p lantar lesions
ZHU Fu-qiang;E Zhan-sen;JIANGHui;SHIXiao-lin;ZENG Hai-wen;ZHANG Yong-hong
Objective
To discuss the diagnostic value of high-frequency ultrasound in the plantar lesions.
Methods
From January 2015 to December 2017,the ultrasonographic data of 785 patientswith sole lesions of the foot in our hospitalwere analyzed retrospectively,and summarized the ultrasonographic features of the common plantar lesions.
Results
Themain types of plantar lesions in 785 cases included plantar inflammation,plantar foreign body,plantar lump,and the plantar trauma.Plantar inflammation mainly included plantar fat pad,plantar fasciitis.Themost common of plantar lump were the ganglion of the tendon sheath,the giant cell tumor of the tendon sheath,the epidermoid cyst and the hemangioma.The plantar trauma were mainly included tendinopathy and tendon rupture.Plantar inflammation,plantar foreign body,plantarmass,plantar trauma had typical sonographic features.The accuracy of high frequency ultrasound in the diagnosis of plantar inflammation,plantar tumor,plantar injury and plantar foreign body were 93.96%,94.44%,98.27%and 100.00%,respectively.
Conclusion
The sound image of the common foot lesions has certain characteristics,regularity and specificity.High frequency ultrasound can detect the common plantar lesionsmore accurately and quickly.It can be used to identify and diagnose the type and nature of plantar lesions.Which is an effective imagingmethod for the diagnosis of plantar lesions.
2018 Vol. 25 (16): 139-142 [
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118
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143
Analysis the diagnostic value of spiral CT and magnetic resonance in the diagnosis of fallopian tube abscess
XU Xie-sheng;WANG Kai-fu;ZHANG Zhan-qing;LAO Xiao-yi
Objective
To explore the diagnostic value of spiral CT and magnetic resonance imaging (MRI)in the diagnosis of fallopian tube abscess.
Methods
A total of 60 cases of suspected fallopian tube abscess in our hospital from January 2014 to November 2017 were selected as the subject.All the patientswere examined by spiral CT and MRI.The CT images and MRI images of the patientswere analyzed by two doctors tomake a diagnosis respectively.The diagnostic sensitivity,specificity and accuracy of spiral CT and MRI in the diagnosis of fallopian tube abscess were calculated and compared with the results of biopsy or pathological diagnosis.The consistency testwas used to analyze the diagnostic consistency between spiral CT and MRI for the diagnosis of tubal abscess and pathological diagnosis.
Results
Among 60 suspected tubal abscesses,38 cases were diagnosed as tubal abscess by biopsy or surgical pathology.The remaining 22 patients were excluded as fallopian tube abscess.Reference to the results of pathological diagnosis,the diagnostic sensitivity,specificity and accuracy of spiral CT in the diagnosis of fallopian tube abscess were 92.11%,90.91%and 91.67%,respectively,which were respectively 97.37%,95.45%and 96.67%of MRI,and there was no significant difference the twomethods(P＞0.05).The consistency test showed that the diagnostic consistency between spiral CT,MRIand pathological diagnosis for the diagnosis of fallopian tubal abscesswere all good,the Kappa value was 0.716 and 0.703,respectively.
Conclusion
In the diagnosis of fallopian tube abscess,spiral CT and MRIall have high diagnostic accuracy,and their diagnostic results are close to those of pathological diagnosis.Combined diagnosis of spiral CT and MRI can be used as a preoperative diagnosticmethod for fallopian tubal abscess.
2018 Vol. 25 (16): 143-145转149 [
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151
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146
Analysis of the MRImanifestation characteristics of parotid lym phoma
WEN Kang-Yan;CHEN Ze-Wen;LIWei-Feng
Objective
To investigate the distinct MRI characteristics of parotid lymphoma,and provide the basis for the diagnosis and treatment of parotid lymphoma.
Methods
The clinical data of 50 patients with parotid lymphoma treated from January 2013 to December 2017 in our hospitalwas selected.Themanifestation characteristics based on the conventional MRI,dynamic contrast enhancement-MRI(DCE-MRI)and diffusion weighted imaging(DWI)were compared.
Results
A total of 67 lesionswere observed in the 50 patients,including 24 unilateral and single cases,6 unilateral and multiple cases,and 20multi-lateral and multiple cases.For 67 parotid lymphoma lesions,therewere 45 solid lesionswith uniform high T1 and high T2 signal intensity and 22 cystic lesions with diversified signal intensity.A total of 19 patients with 41 leisions received the DCE-MRI examination,37 cases with rapid enhancement and rapid washout enhancement,4 cases with srapid enhancement and slow washout enhancementwere observed.
Conclusion
The combined examination methods of the distinct MRI characteristics can positively improve the diagnosis sensitivity,and make for the clinical diagnosis and differential diagnosis of parotid lymphoma,which has positive clinical application value.
2018 Vol. 25 (16): 146-149 [
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150
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150
Clinical effect of PixieⅠLotion in the treatment of seborrheic dermatitis of scalp
CHEN Yu-yu;CHEN Ben-hua
Objective
To observe the curative effectand security of PixieⅠLotion in the treatmentof seborrheic dermatitis of scalp(SDS).
Methods
The 80 patientswith SDSwere admitted to the outpatient department of the Second People′s Hospital Affiliated to Fujian University of Traditional Chinese Medicine and the Seventh Hospital of Fuzhou City from January 2015 to December 2017,which met the diagnostic criteria and the inclusion criteria,were selected as subjects.They were randomly divided into treatment group and control group,with 40 cases in each group.The treatment group was treated with PixieⅠLotion,while the control group was treated with 2%Ketoconazole Lotion,2 weeks for 1 course of treatment.The symptom scores of skin lesions before and after treatment,treatment effect and adverse reactions of the two groups of patientswere compared.
Results
After 2 weeks of treatment,the symptom scores of skin lesions in the two groups were significantly lower than before treatment,the differences were statistically significant(P＜0.01).And the symptom scores of skin lesions in the treatment group was significantly lower than that in the control group,the differences were statistically significant(P＜0.01).The total effective rate of the treatment group (90.0%)was significantly higher than that of the control group (72.5%),the difference was statistically significant(P＜0.05).No adverse reactions were observed in both groups.
Conclusion
PixieⅠLotion was effective and safe in treating SDS and it deserves the clinical expansion.
2018 Vol. 25 (16): 150-152转160 [
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166
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153
Effect observation of Shexiang Baoxin Pills combined w ith Ligustrazine in the treatment of acute exacerbation of chronic pulmonary heart disease
WAN Le-le;YISong-gang;AO Su-min
Objective
To explore the effect of Shexiang Baoxin Pills combined with Ligustrazine in the treatment of acute exacerbation of chronic pulmonary heart disease.
Methods
From June 2016 to May 2017,100 patients with acute exacerbation of chronic pulmonary heart disease were selected as subjects and randomly divided into four groups(A,B,C and D,respectively)according to the random comprehensive sequentialmethod,each group of 25 cases.Group A was given routinewesternmedicine comprehensive treatment.Group B was given Shexiang Baoxin Pills orally on the basis of routine western medicine comprehensive treatment,2 tablets per time,three times per day,used for 10 days.Group C was treated with Ligustrazine 120 mg added into the 250 ml 5%glucose injection or 0.9%sodium chloride injection intravenous drip for 10 days.Group D was treated with Shexiang Baoxin Pills orally,2 tablets per time,three times per day,and combination with Ligustrazine 120mg added into the 250ml 5%glucose injection or 0.9%sodium chloride injection were injected intravenously for 10 days,on the basis of routine Western medicine.The brain natriuretic peptide(BNP),the first second forced expiratory volume ratio (FEV
1
%),arterial blood oxygen partial pressure(PaO
2
),arterial blood carbon dioxide partial pressure (PaCO
2
)and treatment total efficiency before and after treatmentwere compared with the four groups of patients.
Results
After treatment,the BNP levels of patients in the A,B,C group were lower than before the treatment,the differenceswere statistically significant(P＜0.05),while therewas no statistically significant difference of patients in group D before and after treatmentwith BNP levels(P＞0.05).The BNP level of group D was higher than that of group A,B and C,and the differences were statistically significant(P＜0.05).After treatment,the FEV
1
%and PaO
2
in the four groupswere higher than before treatment,and the differenceswere statistically significant(P＜0.05).After treatment,the FEV
1
%and PaO
2
in group D were higher than those in the group A,B and C,and PaCO
2
was lower than that in the group A,B and C,with statistically significant differences (P＜0.05).The total effective rate of clinical treatment in group D was higher than that in group A,B and C,and the differenceswere statistically significant(P＜0.05).
Conclusion
Shexiang Baoxin Pills combined with Ligustrazine in the treatment of acute exacerbation of chronic pulmonary heart disease has a significanteffect on improving cardiopulmonary function.
2018 Vol. 25 (16): 153-156 [
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150
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Effect of Shensong Yangxin Capsules combined w ith Spironolactone in the treatment of chronic heart failure
HU Yong-yi;FENG Li
Objective
To explore the clinical value of Shensong Yangxin Capsules combined with Spironolactone in the treatment of chronic heart failure.
Methods
A total of 80 patientswith chronic heart failure who had received treatment in our hospital from January 2016 to September 2017 were selected as subjects,and randomly divided into two groups by random number tablemethod,with 40 cases in each group.The control group was treated with Spironolacton,and the observation group was treated with Spironolactone combined with Shensong Yangxin Capsules.The electrocardiogram indexs,heart rate variability indexs,the levels of C-reactive protein(CRP)and serum N-terminal pro-B-type natriuretic peptide(NT-proBNP)were compared between the two groups.
Results
After treatment,electrocardiography(ECG)indexes(QTD,QRSwave,QTcd)in the observation group were lower than those in the control group,and the differenceswere statistically significant(P＜0.05),but the heart rate variability indexes(PNN50,rMSSD,SDANN,SDNN)in the observation group were higher than those in the control group,the differenceswere statistically significant(P＜0.05).After treatment,the levels of CRP and NT-proBNP in the observation group were respectively(5.09±1.16)mg/L and(567.52±96.33)pg/ml,which were both lower than those in the control group ([6.29±1.27]mg/L,[716.25±132.64]pg/ml),the differences were statistically significant(P＜0.05).The LVEF in the observation group was(59.29±5.16)%,which was higher than that in the control group of(53.02±6.21)%,and the difference was statistically significant(P＜0.05).
Conclusion
For patients with chronic heart failure,the combined therapy of Shensong Yangxin Capsules combined with Spironolactone can effectively improve the indexes of ECG and heart rate variability,and reduce the levels of CRP and NT-proBNP.
2018 Vol. 25 (16): 157-160 [
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154
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161
Clinical effect observation of Tiotropium Brom ide Powder Inhalant in the treament of bronchiectasis
LIU Huan;LIU Ning;BAIGuo-feng
Objective
To investigate the clinical effect of Tiotropium Bromide Powder Inhalant therapy for bronchiectasis.
Methods
A total of 98 patientswith bronchiectasis admitted to our hospital from April 2016 to April 2017 were selected as subjects.They were divided into control group and observation group according to the order of hospital admission,49 patients in each group.In the control group,conventional treatmentwas provided,while in the observation group,on the basis of the control group,Tiotropium Bromide Powder Inhalantwas added.The experimental data such as deep inspiratory volume,forced expiratory volume and effectiveness total rate before and after treatment in the two groups were observed.
Results
After treatment,the deep inspiratory volume and forced expiratory volume in the observation group were(1.98±0.31)ml and(2.56±0.71)L,which were higher than those in the control group of(1.78±0.35)ml and(2.01±0.68)L,the differenceswere statistically significant(P＜0.05).After treatment,the clinical symptom score of the observation group was(2.18±0.11)points,which was lower than that of the control group of(3.25±0.25)points,the difference was statistically significant(P＜0.05).After treatment,the therapeutic effectiveness total rate was 93.88%in the observation group,which wasmuch higher than that in the control group accounting for 75.51%,the difference was statistically significant(P＜0.05).
Conclusion
Tiotropium Bromide Powder Inhalant has a definite effect on treating bronchiectasis,which can remarkably improve the clinical indicators and increase the therapeutic effectiveness rate.It′s worth spreading.
2018 Vol. 25 (16): 161-163转167 [
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Therapeutic effect of Fluticasone Propionate combined w ith M ontelukast for chronic cough caused by Mycoplasma Pneumoniae in infants
#br#
Therapeutic effect of Fluticasone Propionate combined w ith M ontelukast for chronic cough caused by Mycoplasma Pneumoniae in infants #br#[J]. 中国当代医药, 2018,25(16): 164-167')" href="#">
CHEN Xia;LONG Zhen;HUANG Yang;SHU Jun-hua
Objective
To explore the effect of Fluticasone Propionate combined with Montelukast in the treatment of chronic cough caused by Mycoplasma pneumoniae infection in infants.
Methods
A total of 60 infants with chronic cough caused by Mycoplasma pneumoniae infection treated in our hospital from July 2016 to June 2017 were selected as subjects and randomly divided into the control group and the observation group,30 cases in each group.The control group was treated with Azithromycin Granules,the observation group was treated with Azithromycin Granules,Fluticasone Propionate Inhaled Aerosol and Montelukast Sodium Chewable Tablets.The cough symptomatic scores on the first,seventh,tenth,twenty-eighth days of treatmentwere compared,and the disappearance time of the cough symptoms were recorded.The clinical efficacy was compared between the two groups.All the children were followed up for 3months after treatment,the frequency of repeated attackswere observed.
Results
Therewas no significant difference in cough symptom scoresbetween the two groupson the firstday of treatment(P＞0.05).The cough symptomatic scoreswere significantly lower in the observation group than those in the control group on the seventh,tenth,twenty-eighth days of treatment(P＜0.01).The total clinical effect of the observation groupm was 93.3%,which was obviously higher than that of the control group(63.3%),the difference was statistically significant(P＜0.05).The cough disappearance time in the observation group was shorter than that in the control group,the difference was statistically significant(P＜0.01),and during the follow-up period of 3 months,the number of recurrences of children in the observation group was less than that of the control group,the difference was statistically significant(P＜0.01).
Conclusion
Therapy on chronic cough caused by Mycoplasma Pneumoniae infection in infantswith combination of Fluticasone Propionate and Montelukastadjuvant has significant effect.
2018 Vol. 25 (16): 164-167 [
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140
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Effect of pharmacological services on medication com p liance and sickness condition control of patientsw ith system ic lupus erythematosus
FU Shi-jing
Objective
To understand the effects of pharmacological services on medication compliance and sickness condition control of patientswith systemic lupus erythematosus(SLE).
Methods
A total of 70 SLE patients confirmed by department of rheumatology and immunology in our hospital from January 2016 to April 2017 were selected as subjects.They were randomly divided into two groups,each with 35 cases.The control group was given regular pharmaceutical services,and the intervention group was given targeted pharmaceutical services.The Morisky medication compliance scale(MMAS-8)and the disease activity in SLE scale(SLE-DAI)were compared between the two groups before and 2,4,6 months after intervention.
Results
Before intervention,there was no significant difference in MMAS-8 and SLEDAIscores between the two groups (P＞0.05).In the 2,4,6 months after the intervention,the MMAS-8 scores of the patients in the intervention group were higher than those in the control group,and the differenceswere statistically significant(P＜0.05).In the 2,4,6 months after the intervention,the SLE-DAI scores of the patients in the intervention group were lower than those in the control group,and the differenceswere statistically significant(P＜0.05).
Conclusion
Pharmacological services for patients with SLE can improve the compliance ofmedication compliance.Good adherence to medication is beneficial to the sickness condition control of patientswith SLE.And it has great significance to the longterm prognosis of patientswith SLE.It isworth spreading.
2018 Vol. 25 (16): 168-170 [
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165
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Efficacy evaluation of Compound Lysine Hydrochloride and Zinc Gluconate Granules assisted Bifidobacterium triple live bacteria plus M ontmorillonite Powder in the treatment of infantile diarrhea
ZHONGWei-cheng;CHEN Xiao-ru;DU Yun-zi
Objective
To evaluate the efficacy of Compound Lysine Hydrochloride and Zinc Gluconate Granules assisted Bifidobacterium triple live bacteria plus Montmorillonite Powder in the treatment of infantile diarrhea.
Methods
A total of 128 children with acute diarrhea treated in our hospital from October 2016 to December 2017 were selected as subjects and divided into the basic medication group and adjuvantmedication group according to the system randomization,64 cases in each group.The basic medication group was treated with Bifidobacterium triple live bacteria plus Montmorillonite Powder,and the adjuvantmedication group was treated with Compound Lysine Hydrochloride and Zinc Gluconate Granules on the basis of the basic medication group.The treatment effect,the improvement of clinical symptoms and the relapse rate of the disease in two groups of children were analyzed and compared.
Results
The total clinical effective rate was 96.87%in the adjuvantmedication group and 84.38%in the basicmedication group,and the total effective rate in the adjuvantmedication group was higher than that in the basic medication group,the difference was statistically significant(P＜0.05).After treatment,the normal times of defecation,the relief time of abdominal pain and diarrhea,the normal time of stool shape,the normal time of stool culture and the recovery time of stool examination of patients in the adjuvantmedication group were significantly lower than those in the basicmedication group,the differences were statistically significant(P＜0.05).The rates of disease recurrence at 1,2,and 3 months after treament of patients in the adjuvantmedication group were lower than those in the basicmedication group,the differenceswere statistically significant(P＜0.05).
Conclusion
Compound Lysine Hydrochloride and Zinc Gluconate Granules has a significant effect on the adjuvant treatment of acute diarrhea in children,which can significantly improve the clinical efficacy.The symptoms of various diarrhea in children are improved rapidly,the recurrence rate is low,the prognosis is good.
2018 Vol. 25 (16): 171-173 [
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156
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Effect of Probiotics and M esalazine in the treatment of inflammatory bowel disease
ZHANG Hong-wei;ZENG Jing-ke
Objective
To explore the efficacy and safety of Probiotics and Mesalazine in the treatment of inflammatory bowel disease.
Methods
A total of 86 cases of inflammatory bowel disease patients treated in our hospital from August 2015 to December 2017 were selected as subjects.The patientswere divided into two groups according to the admission order,and each group was 43 cases.The patients in control group were given Mesalazine,the patients in the observation group were treated with Methalazine and Probiotics.The total effective rate,the incidence of adverse reaction,severity of of adverse reactions,the levels of inflammatory factors(Tumor necrosis factor-α [TNF-α],interleukin-6[IL-6]and interferon-γ [IFN-γ])and intestinal barrier function index(urine lactulose/mannitolrate[L/M])were compared between the two groups.
Results
After 8 weeks of treatment,the total effective rate of treatment in the observation group was higher than that of the control group,and the difference was statistically significant(P＜0.05).There was no significant difference in the incidence of adverse drug reactions between the two groups during the treatment(P＞0.05).There was no significant difference in the severity of adverse reactions between the two groups(P＞0.05).After 8 weeks of treatment,the levels of TNF-α,IL-6 and IFN-γ in the observation group were lower than those of the control group,the differenceswere statistically significant(P＜0.05).The level of L/M in the observation group was lower than that of the control group,and the difference was statistically significant(P＜0.05).
Conclusion
Probiotics combined with Mesalazine is effective in treating inflammatory bowel disease,which can improve intestinal barrier function,relieve inflammatory reaction,shorten treatment course,and with high safety.It isworth promoting.
2018 Vol. 25 (16): 174-176转186 [
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161
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Effect of massage combined w ith functional training in treatment of patientsw ith lumber disc herniation at recovery stage
ZHENG Yan-qing;ZHENG Li-qin;ZHANG Feng-hua
Objective
To observe the effect ofmassage combined with functional training in treatment of patients with lumber disc herniation(LDH)at recovery stage.
Methods
A total of 70 patientswith LDH at recovery stagemeeting the inclusion criteria from June 2016 to June 2017 treated in ourhospitalwere selected as the research object,all patientswere divided into 35 cases of observation group and 35 cases of control group according to random number tablemethod.The control group was treated with functional training,while the observation group were given massage therapy on the basis of the control group,both group had been treated for 12 weeks.Before treatment and after 12 weeks treatment,the VAS and JOA scorewere assessed to evaluate the improvementof pain,the ODIwas assessed to evaluate the lumbar function,the flexion maximum muscle strength were detected by spinal test evaluation training system,the walking ability were assessed and the effectwere evaluated.
Results
VAS score of the observation group and the control group after treatment was(1.06±0.48),(2.32±0.65)points,JOA scorewas(27.88±2.46),(24.90±2.42)points,ODIwas(32.08±16.06)%,(45.15±15.83)%,the flexionmaximum muscle strength was(300.86±54.35),(270.42±58.52)respectively,and the differenceswere statistically significant(P＜0.05).Thewalking ability of the observation group and the controlgroup after treatmentwere significantly better than those before treatment(P＜0.05),and the walking ability of the observation group after treatmentwas significantly better than thatof the control group(P＜0.05).The totaleffective ratesof the observation group and the controlgroup was 97.14%and 74.29%respectively,and the difference between the two groupswas statistically significant(χ
2
=8.525,P＜0.05).
Conclusion
Massage given on the basis of functional training treating lumber disc herniation at recovery stage can effectively improve the symptoms and signs,flexormuscle function and lower limb motor function of patients,so as to improve the clinical therapeutic effect.
2018 Vol. 25 (16): 177-179转193 [
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153
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180
Clinical observation of Buzhong Yiqi Decoction in the treatment of cough variant asthma
ZHAN Zi-e;LIYou-heng;TANGWen-hui
Objective
To observe the clinical effect of Buzhong Yiqi Decoction in the treatment of cough variantasthma.
Methods
Eighty patientswith cough variant asthma treated in our hospital from October 2013 to September 2017 were divided into the control group and study groupm,and there were 40 cases in each group according to the random number tablemethod.The control group was given the routine westernmedicine treatmentwhile the study group was treated with Buzhong Yiqi Decoction on the treatment of the control group.And the clinical curative effect after the treatment,expression levels of serum and sputum inflammatory factors before and after the treatment of two groupswere observed.
Results
The total effective rate of the study group after treatmentwas obviously higher than that of the control group,the expression levels of serum and sputum inflammatory factors of two groups after 1 and 2 weeks were significantly decreased,and the expression levels of serum and sputum of study group were all lower than the levels of control group,and the differences of two groupswere all significant(P＜0.05).
Conclusion
The clinical effect of Buzhong Yiqi Decoction in the treatment of cough variant asthma is better,and it has better anti-inflammation mechanism,so it is worth popularizing and applying in patientswith cough variant asthma.
2018 Vol. 25 (16): 180-182 [
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164
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183
Clinical observation of Liangxue Pingyin Decoction combined w ith Feng′ai Lotion treating psoriasis vulgaris
CHEN Hui-juan;HONGWen;JIANG Li-ying;XIE Yun-ling
Objective
To observe the clinical effect of Liangxue Pingyin Decoction combined with Feng′ai Lotion treating psoriasis vulgaris.
Methods
Sixty patientswith psoriasis vulgarismeetting the inclusion criteria treated in our hospitalwere selected as the study subjects from January 2015 to December 2016.The patientswere divided into the treatment group(30 cases)and control group(30 cases)according to the random number tablemethod.The treatment group was given Liangxue Pingyin Decoction combined with Feng′ai Lotion treatment,while the control group was given oral Avia A Capsules treatment.The two groups were treated with 4 weeks for one course of treatment.After 2 courses of treatment,the curative effect,lesion degree,lesion area and pruritus score were evaluated and the incidence of adverse reactions between the two groupswere compared.
Results
After the first course of treatment,the total effective rate of the treatmentgroup was higher than thatof the control group(P＜0.05).After the second course of treatment,therewas no significant difference of curative effectbetween the two groups(P＞0.05).After treatment,the lesion area,skin lesion and itching score of the two groups decreased,and the treatment group decreased more significantly than the control group (P＜0.05).The rates of dry lips,dry skin,nausea and abnormal liver and kidney function in the treatment group were lower than those in the control group(P＜0.05).
Conclusion
Liangxue Pingyin Decoction combined with Feng′ai Lotion treating psoriasis vulgaris has obvious advantages and the adverse reaction is fewer than that of Avia A Capsules,and the compliance of patients is better.
2018 Vol. 25 (16): 183-186 [
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143
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187
Effect of invigorating spleen benefiting liver and kidney treating children′s vitiligo at stable period
CHEN Rui-ping;YANG Qing-qi;LIYuan-li;SHIFei
At present,there are few traditional Chinesemedicine studies on the children′s vitiligo at stable period,which are often seen in the treatment of adult vitiligo.Sorting out the etiology and pathogenesis of vitiligo and classification of traditional Chinese Medicine,combined with large sample epidemiological investigation and the physiological and pathological characteristics of children,the author propose that deficiency of liver and kidney,weakness of spleen and stomach are themain etiology and pathogenesis of the children′s vitiligo at stable period.The treatmentmethod is to invigorate the spleen and to benefit the liver and kidney,considering qi activating and blood circulation as appropriate,then conduct proper addition or subtraction according to the inducing factors and the condition of tongue coating.It is no need to consider synthesis of the four diagnosticmethods.The clinical effect is very significant.
2018 Vol. 25 (16): 187-189 [
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129
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190
The clinical effect of fire needle w ith"fire stagnation requiring dissipation"treating acute gouty arthritis
XIE Li-qin;LILi-xia;HUANG Ying-jie;LU Cui-na;HUANGWen-gai
Objective
To explore the clinical effect of fire needle with"fire stagnation requiring dissipation"treating acute gouty arthritis.
Methods
A total of 60 patientswith acute gouty arthritis admitted into the department of acupuncture andmoxibustion from October 2016 to October 2017 were selected as the subjects and they were randomly divided into the treatment group and the control group,there were 30 cases in each group.The treatment group was given fire needle treatmentwhile the control group was given Etoricoxib Tablets and small dose of Colchicine treatment.The clinical effects between the two groups were compared.
Results
There was no significant difference in the comprehensive score and VAS score in the two groups after treatment(P＞0.05).After treatment,the comprehensive score and VAS score were significantly decreased,compared with those before treatment,the difference was statistically significant(P＜0.05).The comprehensive score and VAS score in the treatment group were significantly lower than those in the control group and the time of pain relief and the duration of pain were significantly shorter than those in the control group,and the differences between the two groupswere statistically significant(P＜0.05).The total effective rate of the two groupswas not statistically significant(P＞0.05).
Conclusion
Fire needle therapy in the treatment of acute gouty arthritis can effectively improve joint symptoms,and its effect is equivalent to western medicine,but its analgesic effect is better than westernmedicine,and it isworthy of clinical promotion.
2018 Vol. 25 (16): 190-193 [
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136
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Effect of com prehensive nursing intervention in patients w ith dysfunctional uterine bleeding
OU Pei-yi
Objective
To explore the clinical effect and the satisfaction of patients to nursing of comprehensive nursing intervention on patientswith dysfunctional uterine bleeding.
Methods
Sixty patientswith dysfunctional uterine bleeding admitted to our hospital from January to November 2017 were selected as the research object.Random number table method was used to divide them into control group and observation group,with 30 cases in each group.All patientswere treated with benoite tablets and kangfuling capsules.The control group was given routine nursing intervention,and the observation group was given comprehensive nursing interventionmeasures on the basis of routine nursing.The bleeding time,clinical efficacy and satisfaction of patients with nursing care in two groups were compared.
Results
The bleeding hemostasis time([3.47±1.26])d in the observation group was significantly shorter than that in the control group([5.22±2.14])d,and the difference was statistically significant(t=3.859,P=0.000).The total effective rate of patients in the observation group was significantly higher than that in the control group,and the differencewas statistically significant(P＜0.05).During the nursing period,2 cases of urethral bacterial infection were found in the control group,with the infection rate of 6.67%,while no infection occurred in the observation group,with the infection rate of 0.00%,therewas no significant difference in infection rate between the two groups (χ
2
=2.069,P=0.150).Overall satisfaction of the observation group was significantly higher than that in the control group,and the difference was statistically significant(P＜0.05).
Conclusion
The implementation of comprehensive nursing interventions can effectively shorten the hemostasis time and improve the clinical efficacy of patientswith dysfunctional uterine bleeding,and the patients are satisfied with the nursing effect.It isworthy of clinical application.
2018 Vol. 25 (16): 194-196 [
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155
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