高尿酸血症对IgA肾病的影响研究

Abstract
Figure/Table
References (20)
Related Citation (15)

Download: PDF (0 KB) HTML (34 KB)
Export: BibTeX | EndNote (RIS)

Abstract ObjectiveTo understand the clinical indicators and pathological features of patients with IgA nephropathy and hyperuricemia,and to investigate the influence of hyperuricemia on IgA nephropathy.MethodsA total of 125 patients with primary IgA nephropathy definitely diagnosed by pathological detection after renal biopsy who hospitalized in nephrology department of our hospital from March 2013 to June 2017 were enrolled.Among them,the ratio ofmale to female was 44 cases to 81 cases.According to the serum uric acid level,they were divided into the normal uric acid group　(69 cases)and the hyperuricemia group　(56 cases).The indexes of age,gender,serum uric acid,serum creatinine,24-hour urinary protein,serumalbumin,blood cholesterol,triglyceride and hemoglobin were recorded.All patients were performed with renal pathological examinations and Lee parallel grading.The clinical and pathological features of the two groups were statistically analyzed.ResultsThe level of 24-hour urinary protein excretion,serum creatinine,triglyceride and total cholesterol in the hyperuricemia group were higher than those in the normal uric acid group　(P＜0.05).The Lee grading of renal pathology in the hyperuricemia group wasworse than that in normal uric acid group(P＜0.05).ConclusionPatients with IgA nephropathy are likely to develop hyperuricemia.Compared with patients with normal serum uric acid,their clinical manifestations and renal pathological injury are more serious,suggesting that hyperuricemia is associated with the prognosis of IgA nephropathy and should be paid great attention and provided with effective treatment as an intervention in time.

Key words： IgA nephropathy Hyperuricemia Clinical indicators Pathology

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	NILi

Cite this article:

NILi. Study of the influence of hyperuricem ia on IgA nephropathy[J]. 中国当代医药, 2018, 25(16): 72-74.

URL:

http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2018/V25/I16/72

[1]	连希艳，黄胜华，赵劲涛，等.IgA肾病合并高尿酸血症患者临床病理分析[J].实用医学杂志，2010，26（14）：2667-2668.
[2]	Yurieva EA，Sukhorukov VS，Vozdvijenskaia ES，et al.The hypoxic syndrome in children with cardiomyopathy[J].Klin Lab Diagn，2015，60（2）：26-28.
[3]	赖玮婧，刘芳，付平.慢性肾脏病评估及管理临床实践指南解读——从K/DOQI到KDIGO[J].中国实用内科杂志，2013，33（6）：448-453.
[4]	中国医师协会心血管内科医师分会，中国医师协会循证医学专业委员会.无症状高尿酸血症合并心血管疾病诊治建议中国专家共识[J].中国当代医药，2009，16（24）：4-8.
[6]	蔡伟程，韩蜀莲，郭晓丹，等.IgA肾病合并高尿酸血症患者的临床病理分析[J].临床肾脏病杂志，2016，16（3）：152-156.
[5]	LeeSM，RaoVM，FranklinWA，etal.IgA nephropathy：morphologic predictors of progressive renal disease[J].Hum Pathol，1982，13（4）：314-322.
[7]	Coppo R，D′Amico G.Factors predicting progression of IgA nephropathies[J].JNephrol，2005，18（5）：503-512.
[8]	陈香美，陈以平，谌贻璞，等.286例IgA肾病中医辨证与肾脏病理关系的多中心前瞻性研究[J].中国中西医结合杂志，2004，24（2）：101-105.
[9]	Curhan GC，Mitch WE.Diet and kidney disease[A]//Brenner BM.The Kidney[C].8thed.Philadelphia：Saunders Elsevier，2008：1827-1847.
[10]	Johnson RJ，Kang DH，Feig D，et al.Is there a pathogenetic role for uric acid in hypertension and cardiovascular and renal disease[J].Hypertension，2003，41（6）：1183-1190.
[11]	杨念生，武庆庆，杜勇，等.影响IgA肾病预后的危险因素分析[J].中华内科杂志，2005，44（8）：597-600.
[12]	张晓敏，刘宏，刘必成，等.高尿酸血症与慢性肾脏病发生发展关系的研究进展[J].东南大学学报（医学版），2013，32（1）：114-117.
[13]	李申恒，史伟，夏运风，等.尿酸升高IgA肾病临床病理特征变化的比较分析[J].南方医科大学学报，2010，30（1）：133-136.
[14]	Sanchez-Lozada LG，Tapia E，Santamaria J，et al.Mild hyperuricemiainducesvasoconstrictionandmaintainsglomerular hypertension in normal and remnant kidney rats[J].Kidney Int，2005，67（1）：237-247.
[15]	王玉姝，王红月，刘立群，等.氯沙坦治疗IgA肾病合并高尿酸血症患者的疗效[J].中国老年学杂志，2011，31（17）：3238-3239.
[16]	Ben-Dov IZ，KarkJD.Serum uric acid is a GFR-independent long-term predictor of acute and chronic renal insufficiency：the Jerusalem Lipid Research Clinic CohortStudy[J].Nephrol Dial Transplant，2011，26（8）：2558-2566.
[17]	Hovind P，Rossing P，Johnson RJ，et al.Serum uric acid as a new player in the developmentof diabetic nephropathy[J].JRen Nutr，2011，21（1）：124-127.
[18]	高冠群，杨仁江，张卓伯，等.血尿酸水平与缺血性卒中相关分析[J].现代生物医学进展，2012，12（4）：684-686.
[19]	Siu YP，Leung KT，Tong MK，et al.Use of allopurinol in slowing the progression of renaldisease through itsability to lower serum uric acid level[J].Am JKidney Dis，2006，47（1）：51-59.
[20]	Kanbay M，Ozkara A，Selcoki Y，et al.Effect of treatment of hyperuricemia with allopurinol on blood pressure，creatinine clearance，and proteinuria in patients with normal renal functions[J].Int Urol Nephrol，2007，39（4）：1227-1233.