线粒体形态与功能改变在肿瘤中的研究进展

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Abstract Mitochondria are the regulatory center for cellular energy metabolism,substance synthesis,and death.In the developmentand progression of tumor,mitochondria as an important regulator,have a significant impact on the biological behaviors including tumor proliferation,migration,differentiation,and invasion.To approach the changes ofmitochondrial morphology and function,as well as their regulatory mechanism in the development and progression of tumor,will undoubtedly be the key to usingmitochondria as a new generation of cancer therapeutic target.In this paper,the advances in the role ofmitochondria in tumor development and progression are reviewed,in an attempt to elucidate the close association between them.

Key words： Mitochondria Metabolic reprogramming ROS Mitochondrial DNA Tumor

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	Articles by authors
	ZHENG Hong-yi
	WU Xiong-jian
	YANG Jian-fen
	ZHANG Ke
	LIU Yao

Cite this article:

ZHENG Hong-yi,WU Xiong-jian,YANG Jian-fen, et al. Research Progress of M itochondrial M orphological and function changes in Tumor[J]. 中国当代医药, 2018, 25(16): 36-40.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2018/V25/I16/36

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