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2022 Vol. 29, No. 21 Published: 2022-07-28

	5	Construction and expression of anti-CD47 antibody Hu5F9 eukaryotic expression vector
		FAN Bei； ZHANG Jingjing； XING Tikun； LIU Wei； WANG Bin； SONG Luping； AN Wenqi
		Objective To express the antibody Hu5F9 against cluster of differentiation 47 (CD47) in CHO-S cells, then purify and identify the expressed product. Methods The recombinant plasmid containing the genes encoding the light and heavy chains of Hu5F9 was transfected into CHO-S cells for expression. After the cell supernatant were collected for detection, the target antibody was purified and identified by humanized Fc-tag. Results The construction of Hu5F9 vector was verified by double-enzyme digestion and gene sequencing. The cell supernatant was detected by SDS-PAGE, and the antibody light chain, heavy chain and complete antibody bands were visible. After antibody purification, the Western blot identification results showed that the band size was consistent with the expectation. Conclusion Anti-CD47 antibody Hu5F9 was successfully expressed in CHO-S cells, which provided a research basis for subsequent drug research and development.
		2022 Vol. 29 (21): 5-8转13 [Abstract] ( 40 ) HTML (1 KB) PDF (1496 KB) ( 122 )

	9	Application effect of cardiopulmonary ultrasound in evaluating the curative effect of Shenmai Injection combined with Qishen Yiqi Dropping Pills on patients with dilated cardiomyopathy
		CUI Liang
		Objective To investigate the application effect of cardiopulmonary ultrasound in evaluating the curative effect of Shenmai Injection combined with Qishen Yiqi Dropping Pills on patients with dilated cardiomyopathy (DCM). Methods A total of 180 patients with DCM admitted to Jiangxi Provincial People′s Hospital from June 2019 to April 2021 were selected as the research objects, and they were divided into observation group A, observation group B, and control group according to the random number table method, with 60 patients in each group. Patients in observation group A were treated with Shenmai Injection combined with Qishen Yiqi Dropping Pills on the basis of conventional treatment. Patients in observation group B were treated with Qishen Yiqi Dropping Pills on the basis of conventional treatment, and patients in control group were given conventional treatment. The three groups were compared in terms of the clinical effect after 6 courses of treatment, the cardiopulmonary ultrasound parameters and lung ultrasound B-line scores before and after treatment. Results After 6 courses of treatment, the total treatment response rate in observation group A was higher than those in control group and observation group B, and the differences were statistically significant (P<0.05). There was no statistically significant difference in the total treatment response rate between observation group B and the control group (P>0.05). The left ventricular end systolic diameter (LVESD), left ventricular and diastolic diameter (LVEDD), septal-to-posterior wall motion delay (SPWMD), cardiothoracic ratio (CTR) and pulmonary artery systolic pressure (PASP) after treatment in observation group A and observation group B were lower than those in the control group, and left ventricular ejection fraction (LVEF) was higher than that in the control group, the LVESD, LVEDD, SPWMD, CTR and PASP in observation group A were lower than those in observation group B, and LVEF was higher than that in observation group B, the differences were statistically significant (P<0.05). There was no statistically significant difference in lung ultrasound B-line scores among the three groups before treatment (P>0.05). After treatment, the B-line score of observation group A and observation group B were lower than those of control group, and the B-line score of observation group A was lower than that of observation group B, the differences were statistically significant (P<0.05). Conclusion Cardiopulmonary ultrasound can be used to evaluate the curative effect of Shenmai Injection combined with Qishen Yiqi Dropping Pills on patients with DCM.
		2022 Vol. 29 (21): 9-13 [Abstract] ( 39 ) HTML (1 KB) PDF (593 KB) ( 90 )

	14	Clinical application of SGLT-2 inhibitor in type 2 diabetes mellitus with heart failure
		ZENG Qinghong ； HU Xiaowu； XIA Jinlan
		Objective To analyze the effect of sodium-dependent glucose transporter-2 (SGLT-2) inhibitor in the treatment of type 2 diabetes mellitus complicated with heart failure. Methods A total of 80 patients with type 2 diabetes complicated with heart failure admitted to Xinyu People′s Hospital from January 2020 to January 2021 were selected as the research objects, they were divided into control group (40 cases) and observation group (40 cases) according to random number table method. Both groups were treated with conventional anti-heart failure therapy, the control group treated with conventional hypoglycemic treatment, and the observation group treated with SGLT-2 inhibitor hypoglycemic treatment. The incidence of blood glucose, inflammatory factors, oxidative stress and adverse reactions were compared between the two groups. Results There were no significant differences in fasting blood glucose (FPG) and 2 h postprandial blood glucose (2 h PG) levels between two groups before treatment (P>0.05). After treatment, the levels of FPG and 2 h PG in the two groups were lower than before treatment, and the levels of FPG and 2 h PG in the observation group were higher than those in the control group, the differences were statistically significant (P<0.05). Before treatment, there were no significant differences in left ventricular ejection fraction (LVEF), output per wave (SV) and mitral valve inflow ratio (E/A) between two groups (P>0.05). After treatment, LVEF, SV and E/A in the two groups were higher than those before treatment, and LVEF, SV and E/A in the observation group were higher than those in the control group, the differences were statistically significant (P<0.05). There were no significant differences in the levels of C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), malondialdehyde (MDA) and superoxide dismutase (SOD) between two groups before treatment (P>0.05). After treatment, the levels of CRP, TNF-α and MDA in the two groups were lower than those before treatment, while SOD was higher than that before treatment, with statistical significances (P<0.05). After treatment, the levels of CRP, TNF-α and MDA in the observation group were lower than those in the control group, while the level of SOD was higher than that in the control group, with statistical significances (P<0.05). There was no significant difference in 6 min walking distance before treatment between two groups (P>0.05). The 6 min walking distance of the two groups after treatment was longer than that before treatment, and the distance of the observation group was longer than that of the control group, the differences were statistically significant (P<0.05). The rehospitalization rate of heart failure in the observation group was lower than that in the control group, and the difference was statistically significant (P<0.05), while there was no significant difference in cardiovascular mortality between the two groups (P>0.05). The total incidence of adverse reactions in the observation group was lower than that in the control group, and the difference was statistically significant (P<0.05). Conclusion SGLT-2 inhibitor has significant efficacy in patients with type 2 diabetes mellitus complicated with heart failure, such as promoting the improvement of heart function and controlling blood glucose level.
		2022 Vol. 29 (21): 14-17转22 [Abstract] ( 28 ) HTML (1 KB) PDF (617 KB) ( 51 )

	18	Analysis of influencing factors of anastomotic leakage in different cervical anastomoses in patients with esophageal carcinoma after esophagectomy
		TANG Bo ； ZHAO Xia ； LIU Hongbing ； ZHANG Qingfeng ； LIU Kui ； ZHANG Hui
		Objective To explore the influencing factors of anastomotic leakage in different cervical anastomoses in patients with esophageal carcinoma after esophagectomy. Methods A total of 139 cases of patients receiving cervical anastomosis of esophageal carcinoma in Zigong Fourth People′s Hospital from January 2015 to December 2019 were selected retrospectively as research objects. According to different methods of anastomosis, they were divided into manual anastomosis group (61 cases) and mechanical anastomosis group (78 cases). The preoperative and perioperative data were analyzed to compare the incidence of anastomotic leakage between manual anastomosis and mechanical anastomosis. According to the postoperative anastomotic leakage or not, the patients were divided into anastomotic leakage group (18 cases) and non-anastomotic leakage group (121 cases). The risk factors for anastomotic leakage were investigated based on the clinical data. Results The results of univaritate of anastomotic leakage showed that the tumor location, methods of anastomosis, tumor stage, operation time and neoadjuvant chemororadiotherapy were closely associated with anastomotic leakage (P<0.05). Then the results of multivariate analysis showed that mechanical anastomosis (β=0.978, OR=20.322, 95%CI=1.343-201.434), operation time >300 min (β=2.877, OR=1.150, 95%CI=1.101-1.893) were independent risk factors for anastomotic leakage (P<0.05). Among 139 cases of patients, the leakage rate of mechanical anastomosis was 19.2%, which was higher than that in manual anastomosis (4.9%), the difference was statistically significant (P<0.05). In the mechanical anastomosis group, the leakage rate in tubular stomach was higher than the baseball bat-shaped stomach, the difference was statistically significant (P<0.05). Conclusion Operation time and methods of anastomosis are independent risk factors of anastomotic leak. Layered anastomosis could effectively reduce the incidence of anastomotic leakage. Baseball bat-shaped tubular stomach could effectively reduce the incidence of leakage in mechanical anastomosis. End-to-end layered manual anastomos is associated with a lower rate of anastomotic leakage and slight injury in stomach, which is worthy of clinical application.
		2022 Vol. 29 (21): 18-22 [Abstract] ( 32 ) HTML (1 KB) PDF (612 KB) ( 27 )

	23	Clinical significance of intestinal flora and inflammatory factors in patients with diabetic nephropathy
		GUO Shiqiang； LIU Chunlin； WU Qingnian
		Objective To investigate the clinical significance of intestinal flora and inflammatory factors in patients with diabetic nephropathy. Methods A total of 101 patients with type 2 diabetes mellius (T2DM) who were hospitalized in the Sixth Affiliated Hospital of South China University of Technology from January to December 2019 were selected as the study subjects. According to the 24 h urinary albumin excretion rate (UAER), they were divided into group A (UAER≤30 mg/24 h, diabetic normal proteinuria, n=49), group B (30 mg/24 h<UAER≤300 mg/24 h, diabetic microproteinuria, n=30) and group C (UAER>300 mg/24 h, diabetic nephropathy, n=22), and 25 healthy subjects were selected as group D at the same time. The difference of intestinal flora was analyzed by traditional bacterial culture method, and the levels of inflammatory factor interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) were detected, and the correlation was analyzed. Results The Bifidobacterium and Clostridium in group C were lower than those in group A, group B and group D, and the differences were statistically significant (P<0.05). Lactobacillus in group C was lower than that in group D, and the difference was statistically significant (P<0.05). The levels of IL-6 and TNF-α in group C were higher than those in group A, group B and group D, and the differences were statistically significant (P<0.05). The levels of IL-6 and TNF-α were negatively correlated with Bifidobacterium and Clostridium (P<0.05). Conclusion There are significant differences in intestinal flora in patients with diabetic nephropathy. With the increased expression of inflammatory factors, intestinal flora may mediate the occurrence of inflammation and participate in the occurrence and development of diabetic nephropathy.
		2022 Vol. 29 (21): 23-26 [Abstract] ( 38 ) HTML (1 KB) PDF (582 KB) ( 71 )

	27	Advances in immunological research of systemic lupus erythematosus
		LI Zilong ； ZHANG Yunjiao
		Systemic lupus erythematosus (SLE) is a diffuse connective tissue disease characterized by immune inflammation, involving multiple systems and multiple organs. The pathogenesis and clinical manifestation is complex, and the course of disease is prolonged and repeated. Related researches show that the occurrence of SLE is related to the normal immune state of the body being disturbed, resulting in abnormal activation of immune cells and immune molecules in the body, and is a systemic autoimmune disease. In this paper, the pathogenesis of SLE will be summarized from two aspects of immune inducing factors and mechanism and immune pathological injury mechanism, and the diagnosis and treatment methods of SLE will be reviewed from the perspective of immunology. This study aims to provide data support for further exploring the pathogenesis of SLE, and thus open up a new approach for the prevention, detection and treatment of SLE.
		2022 Vol. 29 (21): 27-30 [Abstract] ( 37 ) HTML (1 KB) PDF (498 KB) ( 48 )

	31	Role of Notch signaling in craniomaxillofacial bone development and bone metabolism
		TAN Hao； XU Wenjie； HE Xinyi； ZHENG Leilei
		Due to its special anatomical structure, cranialmaxillofacial bones have various development modes, including endochondral, intramembrane and suture osteogenesis, in which chondrocytes and osteoblasts differentiated from mesenchymal cells play a key role. Under the action of osteoblast-osteoclast coupling bone metabolism, the developed cranialmaxillofacial bones will continue to grow and rebuild, and abnormal bone metabolism will lead to problems such as bone remodeling imbalance, bone absorption and bone healing disorders. In recent years, Notch signaling has received more and more attention for its important role in cranialmaxillofacial bone development and bone metabolism. Notch signal, as a classical signal related to development, affects the differentiation and function of bone development and metabolism related cells such as mesenchymal cells, chondrocytes, osteoblasts and osteoclasts. Cranialmaxillofacial bones with special development patterns, such as condyle, cranial suture and alveolar bone, have also been revealed to be closely associated with Notch signaling. This article reviews the role of Notch signaling in cranialmaxillofacial bone development and bone metabolism, in order to provide new ideas for the prevention and treatment of related diseases.
		2022 Vol. 29 (21): 31-35 [Abstract] ( 32 ) HTML (1 KB) PDF (518 KB) ( 38 )

	36	Research progress of lipomatous meningioma
		JIANG Gufeng； ZHOU Jie
		Lipomatous meningioma (LM) is a form of meningioma metaplasia, which originates from the accumulation of intracellular liposomes caused by metabolic changes. This paper comprehensively introduces the clinical, pathological, pathophysiological and imaging features of lipomatous meningioma. The main clinical symptoms of this disease are seizures and headaches, and the specific clinical manifestations are visual impairment and visual seizures. The symptoms can appear ten years before the diagnosis of LM and can be completely relieved by specific surgery. The CT findings of LM showed low density due to high fat content, while in MRI, the lesions showed high signal intensity and loss of signal in fat suppression sequence T1-T2. Immunohistochemically, fatty meningioma cells were positive for epithelial membrane antigen, vimentin, CD99, S-100 protein and progesterone receptor. In addition, the risk of recurrence of LM is about 17%. At the same time, studies have shown that there is a significant relationship between immunohistochemical and imaging features, so the accurate combination of immunohistochemical and imaging features is helpful for early diagnosis and is the key to the treatment of LM.
		2022 Vol. 29 (21): 36-39转44 [Abstract] ( 41 ) HTML (1 KB) PDF (521 KB) ( 54 )

	40	Research progress of thrombus elastic graph in the diagnosis and treatment of deep venous thrombosis
		ZHANG Chaojie； ZHAO Hui
		Deep venous thrombosis is a common and potentially fatal disease. At present, there are some limitations in the diagnosis and treatment of deep venous thrombosis. Common coagulation tests cannot effectively screen some high-risk patients and may not provide accurate treatment guidance decisions. Thrombus elastic graph (TEG) technology can simulate the whole process of thrombosis in vitro, can objectively and accurately show the reaction time, blood clot formation time, blood clot formation rate, maximum amplitude, coagulation index and other related information, comprehensively and accurately reflect human coagulation function, and provide guidance for clinical prevention, diagnosis and treatment of deep venous thrombosis. This paper reviews the research progress of thromboelastography in the field of clinical diagnosis and treatment of deep venous thrombosis.
		2022 Vol. 29 (21): 40-44 [Abstract] ( 40 ) HTML (1 KB) PDF (542 KB) ( 74 )

	45	Application effect of Insulin pump in patients with sudden deafness and diabetes mellitus
		WEN Peigui； LIU Lijuan； WEN Fangcong； ZHONG Xun； LI Hang； WANG Wenkai
		Objective To explore the application effect of Insulin pump in patients with sudden deafness and diabetes mellitus. Methods A total of 60 patients with sudden deafness and diabetes mellitus admitted to General Hospital of Pingxiang Mining Group Co., Ltd. from September 2017 to September 2020 were selected as the research objects, and they were divided into the control group and the treatment group according to the random number table method, with 30 cases in each group. The treatment methods for sudden deafness were the same in the two groups. The control group was treated with routine hypoglycemic therapy, and the treatment group was treated with Insulin pump. The effect of hearing and blood glucose control were compared between the two groups. Results The total effective rate of the treatment group was higher than that of the control group, the difference was statistically significant (P<0.05). There were no significant differences between the two groups in fasting blood glucose and two hours postprandial blood glucose (P>0.05). The time of reaching the standard of blood glucose in the treatment group was shorter than that in the control group, the amount of insulin in the treatment group was less than that in the control group, the effective control rate of blood glucose in the treatment group was higher than that in the control group, the differences were statistically significant (P<0.05). Conclusion Insulin pump applied in patients with sudden deafness and diabetes mellitus can effectively control blood glucose and improve the curative effect of sudden deafness.
		2022 Vol. 29 (21): 45-47转55 [Abstract] ( 43 ) HTML (1 KB) PDF (476 KB) ( 49 )

	48	Clinical application effect of Kaiselu deep enema through disposable anal canal in the treatment of children with functional intestinal obstruction
		HE Fuyu ； XIE Meiyan ； ZHONG Xiaoyan； PENG Xiaoyan ； ZHAO Ailian ； HUANG Ting
		Objective To explore the clinical application effect of Kaiselu deep enema through disposable anal canal in the treatment of children with functional intestinal obstruction. Methods A total of 60 children with functional intestinal obstruction treated in Ganzhou Maternal and Child Health Hospital from September 2020 to August 2021 were selected as the research objects, and they were divided into the control group and the observation group by single and double order method of hospitalization number, with 30 cases in each group. The control group was given Kaisai enema with traditional method, and the observation group was given Kaisai enema with disposable anal canal. The clinical efficacy, symptom score, visual analogue scale (VAS), symptom improvement index and incidence of adverse events were compared between the two groups. Results The total effective rate of the observation group was higher than that of the control group, the difference was statistically significant (P<0.05). Before treatment, there were no significant differences in symptom score and VAS score between the two groups (P>0.05). After treatment, the symptom scores and VAS scores of the two groups were lower than those before treatment, and the symptom scores and VAS score of the observation group were lower than those of the control group, the differences were statistically significant (P<0.05). The antiemetic time, anal recovery defecation and exhaust time and hospitalization time of the observation group were shorter than those of the control group, the stool output after enema, anal contraction times and defecation times of the observation group were more than those of the control group, the intestinal peristalsis time of the observation group was longer than that of the control group, and the abdominal circumference of the observation group was smaller than that of the control group, the differences were statistically significant (P<0.05). The total incidence of adverse events in the observation group was lower than that in the control group, the difference was statistically significant (P<0.05). Conclusion The application of Kaiselu deep enema through disposable anal canal in children with functional intestinal obstruction can significantly improve their gastrointestinal function and promote their early recovery.
		2022 Vol. 29 (21): 48-51 [Abstract] ( 39 ) HTML (1 KB) PDF (500 KB) ( 37 )

	52	Application effect of exercise and breathing training in rehabilitation treatment of chronic obstructive pulmonary disease
		ZHAN Zhao； XIAO Mingyan
		Objective To explore the application effect of exercise and breathing training in the rehabilitation of chronic obstructive pulmonary disease. Methods A total of 100 patients with chronic obstructive pulmonary disease admitted to Yunyang District People′s Hospital of Shiyan City from February 2020 to February 2021 were selected as the research objects, and they were divided into the control group and the study group according to the random number table method, with 50 cases in each group. The control group was treated with routine rehabilitation, while the study group was treated with exercise and breathing training on the basis of the control group. The scores of modified British medical research council (mMRC), forced expiratory volume in the first second (FEV1), forced vital capacity (FVC) and generic quality of life inventory-74 (GQOL-74) before and after treatment were compared between the two groups. Results Before treatment, there was no significant difference in the mMRC score between the two groups (P>0.05). After treatment, the mMRC scores of the two groups were lower than those before treatment, and the mMRC score of the study group was lower than that of the control group, the differences were statistically significant (P<0.05). Before treatment, there were no significant differences in FEV1 and FVC between the two groups (P>0.05). After treatment, FEV1 and FVC of the two groups were higher than those before treatment, and FEV1 and FVC of the study group were higher than those of the control group, the differences were statistically significant (P<0.05). Before treatment, there was no significant difference in GQOL-74 scores between the two groups (P>0.05). After treatment, GQOL-74 scores of the two groups were higher than those before treatment, and GQOL-74 score of the study group was higher than that of the control group, the differences were statistically significant (P<0.05). Conclusion The effect of exercise and breathing training in the rehabilitation treatment of patients with chronic obstructive pulmonary disease is remarkable. It can effectively alleviate the symptoms of dyspnea, improve the pulmonary function and the quality of life of patients. It is worthy of clinical promotion.
		2022 Vol. 29 (21): 52-55 [Abstract] ( 46 ) HTML (1 KB) PDF (0 KB) ( 12 )

	56	Application effect of "Spider web" abdominal positioning card in the prevention of DVT by subcutaneous injection of anticoagulant after high saphenous vein ligation+stripping
		FANG Simin ； YANG Wenjuan
		Objective To explore the effect of "Spider web" abdominal positioning stuck in patients with high ligation of great saphenous vein+extraction after subcutaneous injection of anticoagulant to prevent lower extremity deep vein thrombosis. Methods Fifty patients who received subcutaneous anticoagulant injection after high ligation of great saphenous vein+extraction in Jiujiang First People′s Hospital from March 2021 to September 2021 were selected as subjects, and were divided into experimental group (n=25) and control group (n=25) according to random number table method. The control group received routine anticoagulant injection intervention. The experimental group used "Spider web" abdominal positioning rotation card standardized subcutaneous injection of anticoagulant. The incidence of subcutaneous hemorrhage, induration and ecchymosis, the incidence of complications and compliance of subcutaneous injection in the last 1 week were compared between the two groups. Results After intervention, the incidence rates of subcutaneous hemorrhage, induration and ecchymosis in experimental group were lower than those in control group, the differences were statistically significant (P<0.05). After intervention, the total incidence of complications in experimental group was lower than that in control group, the difference was statistically significant (P<0.05). After intervention, the compliances of treatment, self-care, medication and rehabilitation exercise in experimental group were higher than those in control group, the differences were statistically significant (P<0.05). Conclusion "Spider web" abdominal positioning clamp for patients with high ligation and extraction of great saphenous vein can effectively reduce the incidence of adverse reactions, reduce the incidence of injection site pain, lower limb swelling, lower limb deep vein thrombosis and other complications, and improve the treatment compliance of patients, which is worthy of popularization and application.
		2022 Vol. 29 (21): 56-58转62 [Abstract] ( 29 ) HTML (1 KB) PDF (1149 KB) ( 32 )

	59	Application effect of ultrasound-guided Mammotome system in the treatment of benign breast tumors
		TENG Yuan
		Objective To investigate the effect of ultrasound-guided Mammotome system in the treatment of benign breast tumors. Methods A total of 100 patients with benign breast tumors in Guangzhou Women and Children′s Medical Center from March 2019 to March 2021 were retrospectively selected as the research objects, and they were divided into control group (n=47) and observation group (n=53) according to the surgical plan. The control group was treated with traditional breast benign tumor resection, and the observation group was treated with ultrasound-guided Mammotome system, the operative indicators, postoperative complications and therapeutic effect were compared between the two groups. Results The operative duration, intraoperative blood loss, healing time and scar size in the observation group were lower than those in the control group, with statistical significances (P<0.05). The total incidence of postoperative complications in the observation group was lower than that in the control group, the difference was statistically significant (P<0.05). The total effective rate of observation group was higher than control group, the difference was statistically significant (P<0.05). Conclusion In the treatment of benign breast tumors, ultrasound-guided Mammotome system has more significant clinical effect, faster healing, higher safety and minimally invasive advantages.
		2022 Vol. 29 (21): 59-62 [Abstract] ( 32 ) HTML (1 KB) PDF (426 KB) ( 36 )

	63	Application of external fixation in injury-controlled treatment of limb and pelvic trauma fractures
		YANG Yonghua； HU Bin； YANG Minjie； WAN Xianglian； YANG Hailong； GAO Zhanwang
		Objective To explore the application of external fixation in injury-controlled treatment of limb and pelvic trauma fractures. Methods A total of 80 fracture patients admitted to the First People′s Hospital of Jiujiang City from January 2020 to January 2022 were selected as the study subjects, and they were divided into observation group and control group by random number table method, with 40 patients in each group. The control group received traditional plaster fixation, bed rest or bone traction first, and open reduction and internal fixation later. Observation group received external fixation stent fixation combined with injury control treatment, and later received open reduction and internal fixation treatment. The operative time, intraoperative blood loss, incision length, inflammatory factor expression level before and after surgery and the total incidence of postoperative complications were compared between the two groups. Results The amount of intraoperative blood loss in the observation group was less than that in the control group, the operation time and incision length were shorter than those in the control group, and the level of inflammatory factors 3 d after surgery was lower than that in the control group, the differences were statistically significant (P<0.05). The total incidence of complications in observation group was lower than that of the control group, the difference was statistically significant (P<0.05). Conclusion External fixation stent fixation and damage control treatment can shorten the operation time and length of surgical incision in patients with limb and pelvic fractures, reduce intraoperative blood loss, reduce postoperative inflammatory factor expression levels, and reduce the incidence of complications.
		2022 Vol. 29 (21): 63-66 [Abstract] ( 34 ) HTML (1 KB) PDF (500 KB) ( 38 )

	67	Application effect of internal fracture fixation and hip replacement in elderly femoral neck fractures
		YU Haifeng； QIAO Xiaoguang； SUN Guiyao ； ZHENG Hui； CAO Yu； WANG Guibin； LI Shaogang
		Objective To investigate the application effect of internal fracture fixation and hip replacement in elderly femoral neck fractures. Methods A total of 80 patients with femoral neck fracture admitted to Shuangqiao Hospital, Chaoyang District, Beijing from April 2020 to December 2021 were selected as the study subjects. They were divided into control group and observation group according to random number table method, with 40 cases in each group. The control group was treated with internal fixation, and the observation group was treated with hip replacement. The therapeutic effect, surgery related indicators (operation time, intraoperative blood loss, postoperative bed time, postoperative hospitalization time), physical, psychological, social, the overall feel of quality of life and postoperative lower limb muscle pain, urinary tract infection, the total incidence of complications of postoperative deep vein thrombosis of two groups were compared. Results The effective rate of observation group was higher than that of the control group, the difference was statistically significant (P<0.05). The total incidence of postoperative complications of lower limb muscle pain, urinary tract infection and postoperative deep vein thrombosis in the observation group was lower than that in the control group, the difference was statistically significant (P<0.05). The postoperative bed time and postoperative hospitalization time of patients in the observation group were shorter than those in the control group, the operation time was longer than that in the control group, and the intraoperative blood loss was more than that in the control group, the differences were statistically significant (P<0.05). The scores of physical, psychological, social and overall sensory quality of life in the observation group were higher than those in the control group, and the differences were statistically significant (P<0.05). Conclusion In the treatment of elderly patients with femoral neck fracture, hip replacement is more effective than fracture internal fixation, which is beneficial to improve the treatment efficiency, shorten the postoperative bed rest time and postoperative hospitalization time, and improve the quality of life, reduce the incidence of postoperative complications.
		2022 Vol. 29 (21): 67-69转74 [Abstract] ( 324 ) HTML (1 KB) PDF (509 KB) ( 104 )

	70	Therapeutic effect of self-made plaster analgesic ointment for external application on early ankle sprain
		ZENG Yuan； CHEN Jiayi ； HE Jin′an
		Objective To explore and analyze the clinical effect of external application of plaster analgesic ointment in patients with early ankle sprain. Methods A total of 80 patients with early ankle sprain treated in the Second Department of Orthopaedics, Zhongshan Hospital of Traditional Chinese Medicine, Guangdong Province from July 1, 2018 to June 30, 2020 were selected as research objects, they were divided into control group and observation group according to random number table method, with 40 cases in each group. The control group was treated with oral Celecoxib Capsule for analgesia, the observation group was treated with oral Celecoxib Capsule and external application of plaster analgesic ointment, a self-made agent of Zhongshan Hospital of Traditional Chinese Medicine. The treatment effect, symptom and pain improvement at different time points after treatment were compared between the two groups, and the regression time of ecchymosis and joint swelling were recorded. Results The total effective rate of the observation group was higher than that of the control group, the difference was statistically significant (P<0.05). The scores of limb tenderness, the degree of skin ecchymosis and the joint dysfunction in the observation group were lower than those in the control group, the differences were statistically significant (P<0.05). After 3 d, 1 and 2 weeks of treatment, the visual analogue scale (VAS) scores of the observation group were lower than those of the control group, the differences were statistically significant (P<0.05). The regression time of ecchymosis and swelling in the observation group were shorter than those in the control group, the differences were statistically significant (P<0.05). The scores of ankle symptom index (ASI) in the observation group were lower than those in the control group, the differences were statistically significant (P<0.05). Conclusion The clinical symptoms of patients with early ankle sprain can be significantly relieved after external application of self-made plaster analgesic ointment.
		2022 Vol. 29 (21): 70-74 [Abstract] ( 30 ) HTML (1 KB) PDF (511 KB) ( 38 )

	75	Effect of endocrine changes on bone metabolism and bone mineral density in patients with polycystic ovary syndrome
		HAN Zhe； CUI Zhaohui； LI Xinning； LI Jiena； ZHENG Zhixin
		Objective To investigate the effect of endocrine hormonal changes on bone metabolism and bone mineral density in polycystic ovary syndrome (PCOS). Methods A total of 129 patients admitted to the Department of Gynecology and Obstetrics of Heze Municipal Hospital from January 2020 to September 2021 were selected as the research objects, 71 patients with PCOS were included in the PCOS group, and the remaining 58 premenopausal patients were included in the non PCOS group. The levels of serum 25-hydroxy vitamin D (25-[OH]VD), osteocalcin (OC), total N-terminal propeptide of typeⅠprocollagen (TP1NP), β-C-terminal telopeptide of type-Ⅰcollagen (β-CTX), total parathyroid hormone (PTH) and bone mineral density, related sex hormone were compared between two groups. Results The levels of luteinizing hormone/follicle stimulating hormone (LH/FSH), total testosterone (TT) and homeostasis model assessment-insulin resistance (HOMA-IR) in the PCOS group were higher than those of the non-PCOS group, the differences were statistically significant (P＜0.05). The levels of 25-(OH)VD, OC, β-CTX, TP1NP, total T value in the PCOS group were lower than those of the non-PCOS group, the differences were statistically significant (P<0.05). There were no significant differences in the levels of estradiol, PTH and plasma fasting insulin (FINS) between the two groups (P>0.05). Conclusion Endocrine changes in PCOS patients cause bone metabolism changes and bone mineral density decline, which provide important clinical data for preventing and delaying the occurrence of osteoporosis.
		2022 Vol. 29 (21): 75-77转81 [Abstract] ( 31 ) HTML (1 KB) PDF (769 KB) ( 12 )

	78	Application effect of thoracoscopic segmental pneumonectomy in early lung cancer
		ZHOU Guohua； PAN Xingxi； YAO Weishen； XIE Jinglian； GAO Zikun； WU Xiaobo
		Objective To investigate the effect of video-assisted thoracic surgery (VATS) segmentectomy in early lung cancer. Methods A total of 60 patients with early non-small cell lung cancer (NSCLC) in the Sixth Affiliated Hospital of South China University of Technology from November 2019 to October 2021 were selected as the research objects. They were divided into lung lobe group (30 cases) and lung segment group (30 cases) according to the random number table method. The lobar group was treated with VATS lobectomy, and the segmental group was treated with VATS segmentectomy. The perioperative indexes, pulmonary function and complications were compared between the two groups. Results There were no significant differences in intraoperative bleeding, operation time and the number of lymph node dissection between the two groups (P>0.05). The length of hospital stay in the lung segment group was shorter than that in the lung lobe group, the forced expiratory volume in one second (FEV1) and forced vital capacity (FVC) in the lung segment group were higher than those in the lung lobe group, and the differences were statistically significant (P<0.05). The total incidence of complications in the lung segment group was lower than that in the lung lobe group, and the difference was statistically significant (P<0.05). Conclusion The clinical effect of VATS segmental pneumonectomy in the treatment of early NSCLC is equivalent to that of lobectomy, but VATS segmental pneumonectomy has less complications, less impact on patients′ lung function and rapid postoperative recovery. It can be used as a safe and effective method for the treatment of early NSCLC.
		2022 Vol. 29 (21): 78-81 [Abstract] ( 39 ) HTML (1 KB) PDF (418 KB) ( 34 )

	82	Effect of radionuclide strontium chloride combined with Zoledronic Acid in the treatment of bone metastasis of malignant tumor and its effect on the quality of life of patients
		GAN Zhuo
		Objective To explore the overall benefit of radionuclide strontium chloride (89SrCl2) combined with Zoledronic Acid in the treatment of patients with malignant tumor and bone metastasis. Methods One hundred patients with malignant tumors combined with bone metastases admitted to the First Affiliated Hospital of Hu′nan University of Traditional Chinese Medicine from January 2019 to December 2020 were selected as study subjects and divided into the single group (50 cases) and the combined group (50 cases) according to the random number table method, with intravenous 89SrCl2 in the single group and intravenous 89SrCl2 + Zoledronic Acid in the combined group. The bone pain relief, quality of life and adverse effects after treatment were compared between the two groups. Results The improvement of bone pain in the combined group was better than that in the single group, and the total effective rate of improvement was higher than that in the single group, and the differences were statistically significant (P<0.05). The Karnofsky performance scale (KPS) score of patients in the combined group was higher than that of the single group at the end of treatment, and the difference was statistically significant (P<0.05). There were no significant differences in various incidences of adverse reactions between the two groups (P>0.05). Conclusion The combination of 89SrCl2 and Zoledronic Acid can alleviate the symptoms of bone pain in patients with malignant tumor and bone metastasis, improve the quality of life of patients, and has high safety, which is worthy of popularization.
		2022 Vol. 29 (21): 82-84 [Abstract] ( 27 ) HTML (1 KB) PDF (411 KB) ( 50 )

	85	Clinical effect of hormone replacement therapy combined with Kuntai Capsules in the treatment of menopausal high-risk human papillomavirus infection
		CHEN Xianfeng； SHAO Ying ； ZHOU Lihong
		Objective To investigate the clinical effect of hormone replacement therapy combined with Kuntai Capsules treatment in menopausal patients with high-risk human papillomavirus (HPV) infection. Methods A retrospective analysis of the clinical data of 64 postmenopausal HPV-infected patients admitted to Dexing Maternal and Child Health Hospital of Jiangxi Province from July to December 2020. They were divided into the observation group (34 cases) and the control group (30 cases) according to different treatment plans, the control group was treated with vaginal plugs, and the observation group was treated with hormone replacement therapy combined with Kuntai Capsules + vaginal plugs. The efficacy and immune function of the two groups of patients were compared. Results The total effective rate of treatment in the observation group was higher than that in the control group, and the difference was statistically significant (P<0.05). The CD4+ levels of patients of the two groups after treatment were higher than those before treatment, and the CD8+ levels of patients of the two groups after treatment were lower than before treatment, the CD4+ after treatment of patients in the observation group was higher than that of the control group, CD8+ of patients in the observation group was lower than that in the control group, the differences were statistically significant (P<0.05). Conclusion The treatment of menopausal HPV infection with hormone replacement therapy combined with Kuntai Capsules can improve the curative effect of negative conversion and enhance the immune function of patients.
		2022 Vol. 29 (21): 85-87转91 [Abstract] ( 30 ) HTML (1 KB) PDF (637 KB) ( 60 )

	88	Comparison of therapeutic effects of Xiaoer Kechuan Granule combined with Budesonide Atomization and simple atomization in the treatment of children with bronchial asthma complicated with pulmonary infection
		XU Han； ZHANG Fan； WAN Muyuan
		Objective To compare the curative effect of Xiaoer Kechuan Granule combined with Budesonide Atomization and simple atomization in the treatment of bronchial asthma complicated with pulmonary infection. Methods A total of 80 cases of children with bronchial asthma complicated with pulmonary infection admitted to Jiangxi Children′s Hospital from December 2019 to September 2021 were selected as the research objects, they were divided into the observation group and the control group according to random number table method, with 40 cases in each group. The control group was given Budesonide Atomization treatment, and the observation group was given Xiaoer Kechuan Granule on the basis of the above. The clinical efficacy, symptom improvement (duration of dyspnea, disappearance time of lung moist rales, disappearance time of lung wheezing and cough duration), inflammatory level (tumor necrosis factor-α [TNF-α], interleukin-6 [IL-6]) and the incidence of adverse reactions were compared between the two groups. Results The total effective rate of the observation group was higher than that of the control group, and the difference was statistically significant (P＜0.05). The disappearance time of lung moist rales, disappearance time of lung wheezing and cough duration in the observation group were shorter than those in the control group, and the differences were statistically significant (P＜0.05). The level of IL-6 in the observation group after treatment was lower than that before treatment and that in the control group after treatment, and the differences were statistically significant (P＜0.05). There was no significance in the total incidence of adverse reactions between two groups (P＞0.05). Conclusion Xiaoer Kechuan Granule combined with Budesonide Atomization can improve the clinical efficacy and reduce the level of inflammation in children with bronchial asthma complicated with pulmonary infection, which is safe and worthy of clinical attention.
		2022 Vol. 29 (21): 88-91 [Abstract] ( 30 ) HTML (1 KB) PDF (657 KB) ( 97 )

	92	Effect of insulin therapy on blood glucose control and pregnancy outcome in patients with gestational diabetes mellitus during early pregnancy
		CUI Pingli
		Objective To investigate the clinical effect of insulin therapy on gestational diabetes mellitus (GDM) in early pregnancy and its effect on pregnancy outcome. Methods A total of 300 patients with GDM treated in Panyu District Sixth People′s Hospital of Guangzhou from May 2019 to May 2021 were selected as the research objects. They were divided into the control group and the observation group according to ranom number table method, with 150 cases in each group. The control group was treated with insulin after 32 weeks of pregnancy, and the observation group was treated with insulin before 32 weeks of pregnancy. Both groups continued medication until delivery. The clinical efficacy, blood glucose control effect, pregnancy outcome and hypoglycemia were compared between the two groups. Results The total effective rate of the observation group was higher than that of the control group, the difference was statistically significant (P＜0.05). The fasting blood glucose (FPG), 2 hours postprandial blood glucose (2 h PG), mean of daily differences (MODD) and 24 hours mean amplitude of glycemic excursions (MAGE) in the observation group before delivery were lower than those in the control group, and the differences were statistically significant (P＜0.05). The incidence of adverse pregnancy outcomes in the observation group was lower than that in the control group, the difference was statistically significant (P＜0.05). There was no significant difference in the incidence of hypoglycemia between the two groups (P＞0.05). Conclusion Insulin therapy in early pregnancy is more effective in GDM, which can stably control blood glucose level and reduce adverse pregnancy outcomes. It is safe and reliable.
		2022 Vol. 29 (21): 92-94转98 [Abstract] ( 25 ) HTML (1 KB) PDF (639 KB) ( 86 )

	95	Application effect of COOK balloon induced labor in full-term pregnancy women with hypertension
		LAI Lizhen； LIU Li ； LI Lili
		Objective To explore the application effect of COOK balloon induced labor in full-term pregnancy women with hypertension. Methods A total of 136 full-term pregnancy women with hypertension treated in the Department of Obstetrics of Huiyang Sanhe Hospital from February to December 2020 were selected as the research objects. They were divided into the control group (68 cases) and the study group (68 cases) according to random number table method. The control group was induced by oral Misoprostol, and the study group was induced by COOK double balloon. The delivery outcomes, cervical maturity, duration of labor, the mode of delivery and neonatal outcome were compared between the two groups. Results The first stage of labor and the total stage of labor in the study group were lower than those in the control group, the differences were statistically significant (P＜0.05). There was no significant difference in the second stage of labor between the two groups (P＞0.05). There was no significant difference in the Bishop score of cervical maturity between the two groups before intervention (P＞0.05). After intervention, the Bishop score of the study group was higher than that of the control group, the difference was statistically significant (P＜0.05). There were no significant differences in neonatal weight, 5-minute Apgar score, neonatal asphyxia, hyperbilirubinemia and neonatal infection between the two groups (P＞0.05). The vaginal delivery rate in the study group was 75.00%, which was higher than that in the control group (52.94%), the difference was statistically significant (P＜0.05). The incidence rates of uterine contraction, postpartum urinary retention and postpartum hemorrhage in the study group were lower than those in the control group, the differences were statistically significant (P＜0.05). There were no significant differences in the incidences of acute labor and amniotic fluid pollution between the two groups (P＞0.05). Conclusion Compared with Misoprostol induction of labor, the use of COOK double balloon for induction of labor in full-term pregnancy-induced hypertension can help reduce the incidence of complications after delivery, promote cervical ripening, shorten the time of labor, and increase the rate of vaginal delivery. It is worth promoting.
		2022 Vol. 29 (21): 95-98 [Abstract] ( 30 ) HTML (1 KB) PDF (0 KB) ( 12 )

	99	Application effect of peripherally inserted central catheter catheterization under electrocardiogram positioning in premature infant wards
		WU Guifeng ； XU Yaoyao； FANG Lihua
		Objective To explore the application effect of peripherally inserted central catheter (PICC) catheterization under electrocardiogram positioning in premature infant wards. Methods A total of 60 premature infants admitted to Department of Neonatology of Yingtan People′s Hospital were enrolled as research objects from May 2020 to January 2022, according to random number table method, they were divided into the observation group (30 cases) and the control group (30 cases). The control group was given intravenous indwelling needles catheterization, while observation group was given PICC catheterization under electrocardiogram positioning. The success rate of catheterization, catheterization time, hospitalization time, increment of body weight and the occurrence of complications in the two groups were compared. Results The success rate of one-time puncture in the observation group was higher than that in the control group, the difference was statistically significant (P＜0.05). There was no significant difference in the success rate of the twice puncture between the two groups (P>0.05). The retention time of once catheterization in the observation group was longer than that in the control group, the total catheterization time and the total hospitalization time in the observation group were shorter than those in the control group, the differences were statistically significant (P＜0.05). The increment of body weight in the observation group was greater than that in the control group, the difference was statistically significant (P＜0.05). The incidence of complications after catheterization in the observation group was lower than that in the control group, the difference was statistically significant (P＜0.05). Conclusion Compared with traditional intravenous catheterization, PICC catheterization under electrocardiogram positioning can effectively increase the success rate of catheterization, ensure intravenous nutrition supply and accelerate rehabilitation process. One-time catheterization can be retained for a long time, which can reduce the damage induced by multiple catheterization and effectively reduce the risk of related complications.
		2022 Vol. 29 (21): 99-101 [Abstract] ( 30 ) HTML (1 KB) PDF (616 KB) ( 25 )

	102	Clinical application of hysteroscope cold knife technique in the treatment of endometrial polyps
		LIN Zhijin ； CHEN Chunmei ； LU Xiaohong ； CHEN Jianying ； SONG Yuhua ； CHEN Liangwan ； ZHANG Yuanfeng
		Objective To explore the application effect of hysteroscope cold knife technique in the treatment of endometrial polyps. Methods A total of 162 endometrial polyps patients who were admitted to Yangjiang Maternal and Child Health Hospital from August 2020 to August 2021 were selected as research objects. According to the random number table method, they were divided into cold knife group and blind polypectomy group, with 81 cases in each group. Patients in the cold knife group received hysteroscopic cold knife resection, and patients in the blind polypectomy group received blind polypspolypectomy under hysteroscope. The operation time, intraoperative blood loss, and length of hospital stay in the two groups were compared, and the incidence of postoperative adverse reactions in the two groups was observed. Results The operation time of the cold knife group was (22.71±8.52) min, which was shorter than (26.73±8.44) min of the blind polypectomy group, the intraoperative blood loss of the cold knife group was (10.38±5.05) ml, which was less than (13.73±5.23) ml of the blind polypectomy group, and the hospital stay of the cold knife group was (4.00±0.51) d, which was shorter than (4.38±0.72) d of the blind polypectomy group, the differences were statistically significant (P<0.05). The total incidence of adverse reactions in the cold knife group was 3.70% (3/81), which was lower than 12.35% (10/81) of the blinded extraction group, the difference was statistically significant (P<0.05). Conclusion Hysteroscopic cold knife resection in patients with endometrial polyps has the advantages of shorter operation time, less intraoperative blood loss, less postoperative complications and shorter hospital stay. It is worthy of clinical application and promotion.
		2022 Vol. 29 (21): 102-104 [Abstract] ( 31 ) HTML (1 KB) PDF (646 KB) ( 38 )

	105	Clinical effect of hysteroscopic cold knife resection and electroresection in the treatment of infertility of endometrial polyps
		LEI Taoxiang； LYU Wanggui
		Objective To explore the clinical effect of hysteroscopic cold knife resection and electroresection in the treatment of infertility of endometrial polyps. Methods A total of 98 infertility patients with endometrial polyps treated in the First People′s Hospital of Chenzhou City in Hu′nan Province from November 2020 to May 2021 were selected as research objects, they were divided into the control group and the observation group according to random number table method, with 49 cases in each group. Hysteroscopic electroresection was performed in the control group, and hysteroscopic cold knife resection was performed in the observation group. The postoperative follow-up time was 6 months. The perioperative related indexes, menstrual volume, complications, recurrence and pregnancy were compared between the two groups. Results The operation time and postoperative vaginal bleeding time in the observation group ([16.65±3.27] min, [2.04±0.35] d] were shorter than those in the control group ([25.92±3.24] min, [5.32±0.46] d), with significant differences (P＜0.05). There were no significant differences in intraoperative bleeding, pictorial blood loss assessment chart (PBAC) score, the incidence of complication and recurrence rate between the two groups (P＞0.05). The 6-month pregnancy rate in the observation group was 65.31%, which was higher than 34.69% in the control group, with significant difference (P＜0.05). Conclusion Hysteroscopic cold knife resection and electroresection can achieve definite results in the treatment of infertility of endometrial polyps, but hysteroscopic cold knife resection can further shorten the operation and postoperative vaginal bleeding time and improve the pregnancy rate, which is worthy of further clinical promotion.
		2022 Vol. 29 (21): 105-107转111 [Abstract] ( 34 ) HTML (1 KB) PDF (667 KB) ( 44 )

	108	Application effect of laparoscopic pituitrin water separation and exfoliation in patients with ovarian cysts
		YAN Xiaoshuai
		Objective To explore the effect of laparoscopic pituitrin water separation and exfoliation in the treatment of ovarian cysts (OC) and its influence on the quality of patients′ follicles, hormone levels and complications. Methods A total of 80 OC patients admitted to Xiamen Fifth Hospital from January to December 2020 were selected as the research objects, and they were divided into the observation group (n=40) and the control group (n=40) according to random number table method. The control group was treated with conventional laparoscopic cystectomy, and the observation group was treated with laparoscopic pituitrin water separation and exfoliation. The changes of follicle quality (serum leptin [LEP], total antioxidant capacity [TAC], vascular endothelial growth factor [VEGF]), the number of antral follicles [AFC], hormone levels (estradiol [E2], luteinizing hormone [LH], follicle stimulating hormone [FSH]) before and after operation were compared between the two groups, the incidence of postoperative complications and the pregnancy rate within one year in the two groups were statistically analyzed. Results Before operation, there were no significant difference in follicular quality index, AFC, and hormone levels between the two groups of patients (P>0.05). After operation, the levels of LEP, VEGF, E2, LH and FSH in the observation group were lower than those in the control group, and the levels of TAC and AFC in the observation group were higher than those in the control group, the differences were statistically significant (P<0.05). The total incidence of postoperative complications in the observation group was lower than that in the control group, and the difference was statistically significant (P<0.05). The pregnancy rate within one year in the observation group was higher than that in the control group, and the difference was statistically significant (P<0.05). Conclusion Laparoscopic pituitrin water separation and exfoliation in the treatment of OC has a positive effect on improving the quality of follicles and hormone levels in patients. After this surgical treatment, the risk of postoperative complications is lower and the rate of successful pregnancy is higher.
		2022 Vol. 29 (21): 108-111 [Abstract] ( 32 ) HTML (1 KB) PDF (657 KB) ( 37 )

	112	Efficacy and safety of laparoscopy combined with Leprorelin Acetate Sustained-release Microspheres in the treatment of endometriosis
		CAI Feifei
		Objective To explore the clinical effect of laparoscopy combined with Leprorelin Acetate Sustained-release Microspheres in the treatment of endometriosis. Methods A total of 100 cases of patients with endometriosis treated in the Department of Obstetrics and Gynecology of Zhangjiagang Hospital Affiliated to Soochow University from January 2018 to December 2019 were selected as study subjects and divided into reference group (50 cases) and treatment group (50 cases) by randomized digital table method. Both groups were treated with laparoscopic surgery. On this basis, the reference group was orally treated with Deoxygestretenethinyl Estradiol Tablets, and the treatment group was subcutaneously injected with Leprorelin Acetate Sustained-release Microspheres Injection. The levels of reproductive hormones were compared between the two groups before and after treatment. The total effective rate, total incidence of adverse reactions and recurrence rate within 1 year were compared between the two groups. Results Before treatment, there were no significant differences in the levels of luteinizing hormone, estradiol and ovarian follicle stimulating hormone between the two groups (P>0.05). After treatment, the levels of luteinizing hormone, estradiol and ovarian follicle stimulating hormone in the treatment group were lower than those in the reference group, and the differences were statistically significant (P<0.05). The total effective rate in the treatment group was higher than that in the reference group, and the recurrence rate within 1 year was lower than that in the reference group, with statistical significances (P<0.05). There was no significant difference in the total incidence of adverse reactions between the two groups (P>0.05). Conclusion The combination of laparoscopy and Leprorelin Acetate Sustained-release Microspheres in the treatment of endometriosis can regulate the level of reproductive hormones in patients, improve the treatment efficiency, and reduce the recurrence rate.
		2022 Vol. 29 (21): 112-115 [Abstract] ( 30 ) HTML (1 KB) PDF (622 KB) ( 21 )

	116	Application effect of target controlled infusion of Sufentanil combined with Propofol on serum cortisol level in middle-aged elderly patients undergoing pneumoconiosis lavage
		XIONG Jiangqin； FAN Lizhen ； LI Qiuyan
		Objective To explore the application value of Sufentanil combined with Propofol target-controlled infusion in lavage of middle-aged and elderly patients with pneumoconiosis. Methods A total of 80 patients with pneumoconiosis treated by lavage in Jiangxi Chest Hospital from June 2018 to June 2020 were selected as the research objects, and were divided into control group (40 cases) and observation group (40 cases) according to coin toss method. Target-controlled infusion was used in both groups, the control group was given Remifentanil + Propofol, and the observation group was given Sufentanil + Propofol. Blood glucose, serum cortisol levels, postoperative extubation time and recovery time, sedative-agitation score, mean arterial pressure and heart rate were compared between the two groups. Results There was no significant difference in serum cortisol levels between the two groups before surgery (P>0.05). Cortisol level in the observation group was lower than that in the control group 1 h after operation and at postoperative extubation, the differences were statistically significant (P<0.05). The time of extubation and recovery in the observation group were longer than those in the control group, and the differences were statistically significant (P<0.05). The sedative-agitation score of observation group was lower than that of control group, and the difference was statistically significant (P<0.05). After infusion, the heart rate and mean arterial pressure in observation group were higher than those in control group, the differences were statistically significant (P<0.05). Blood glucose in observation group was lower than control group after extubation, the difference was statistically significant (P<0.05). Conclusion The application of Sufentanil combined with Propofol target-controlled infusion in middle-aged and elderly patients with pneumoconiosis after lavage can improve serum cortisol levels and prolong postoperative extubation time and recovery time, thus reducing the stress response.
		2022 Vol. 29 (21): 116-119 [Abstract] ( 34 ) HTML (1 KB) PDF (445 KB) ( 35 )

	120	Application effect of femoral nerve combined with popliteal sciatic nerve block guided by ultrasound in elderly patients with surgery below the knee
		HUANG Pengcheng； FANG Zhichao； QIU Peng； ZHUANG Peimin； ZHENG Hailyu
		Objective To explore the clinical application effect of femoral nerve combined with popliteal sciatic nerve block guided by ultrasound in elderly patients with surgery below the knee. Methods A total of 60 elderly patients with subknee surgery admitted to Chaozhou People′s Hospital from September 2019 to August 2021 were selected as the research objects, they were divided into control group (30 cases) and observation group (30 cases) according to random paper method. The control group received combined lumbar epidural anesthesia, and the observation group received ultrasound guided femoral nerve block combined with popliteal sciatic nerve block. The mean arterial pressure (MAP) and heart rate (HR) before and after anesthesia were compared between the two groups, and the incidence of nausea, vomiting, headache and urinary retention 48 h after surgery were compared between the two groups. Results There was no significant difference in MAP before anesthesia between the two groups (P>0.05). MAP of the observation group was higher than that of the control group at 10, 30 and 60 min after anesthesia, the differences were statistically significant (P<0.05). There was no significant difference in HR between the two groups before and after anesthesia (P>0.05). The pain score of the observation group was lower than that of the control group 24 and 48 h after operation, and the disappearance time of anesthetic drug was shorter than that of the control group, the differences were statistically significant (P<0.05). The incidences of nausea, vomiting, headache and urinary retention 48 h after operation in the observation group were lower than that in the control group, the differences were statistically significant (P<0.05). Conclusion The clinical application effect of femoral nerve combined with popliteal sciatic nerve block guided by ultrasound in elderly patients with surgery below the knee is better，it has good application value.
		2022 Vol. 29 (21): 120-123 [Abstract] ( 30 ) HTML (1 KB) PDF (444 KB) ( 17 )

	124	Clinical effect of wrist ankle acupuncture on acute pain 24 h after operation of mixed hemorrhoids
		LUO Lidan； YE Meixia； HU Ping ； WANG Jing
		Objective To observe the clinical effect of wrist ankle acupuncture on acute pain 24 h after operation of mixed hemorrhoids. Methods A total of 100 patients with postoperative pain of mixed hemorrhoids treated in the Sixth Clinical Medical College of Guangzhou University of Traditional Chinese Medicine from June 2019 to January 2020 were selected as research objects. They were divided into control group and observation group according to random number table method, with 50 cases in each group. The control group was treated with Diclofenac Sodium Suppository, and the observation group was treated with wrist ankle acupuncture. Visual analogue scale (VAS) score, onset time of analgesia and comfort score were compared between the two groups. Results There was no significant difference in VAS score between the two groups before and after treatment (P>0.05). The VAS scores of the two groups after treatment were lower than those before treatment, and the differences were statistically significant (P<0.05). The onset time of analgesia in the observation group was shorter than that in the control group, the difference was statistically significant (P<0.05). There was no significant difference in comfort score between the two groups before treatment (P>0.05). The comfort scores of the two groups after treatment were higher than those before treatment, the differences were statistically significant (P<0.05). The comfort score of the observation group after treatment was higher than that of the control group, the difference was statistically significant (P<0.05). Conclusion When acute pain occurs 24 h after operation in patients with mixed hemorrhoids, the onset time of wrist ankle acupuncture analgesia is shorter than that in the control group. It can quickly relieve the pain and improve the comfort of patients, which is worthy of clinical application.
		2022 Vol. 29 (21): 124-126 [Abstract] ( 28 ) HTML (1 KB) PDF (433 KB) ( 90 )

	127	Clinical effect of auricular acupoint plaster therapy combined with percutaneous acupoint electrical stimulation in acute renal colic
		ZHANG Yehua
		Objective To investigate the clinical effect of auricular acupoint plaster therapy combined with percutaneous acupoint electrical stimulation in the treatment of acute renal colic. Methods A total of 200 patients with acute renal colic severe pain admitted to Changzhou Wujin Hospital of Traditional Chinese Medicine from January to December 2019 were selected as the research objects, they were divided into control group and experimental group according to the random number table method, with 100 cases in each group. The control group was treated with medication, and the experimental group was treated with stomach, spleen and sympathetic auricular acupoints plaster therapy and electric stimulation of Hegu acupoint on the basis of medication. The grading treatment of pain and vomiting were observed in the two groups. Results The pain of experimental group was less than that of control group, the difference was statistically significant (P<0.05). The vomiting of experimental group was less severe than that of control group, the difference was statistically significant (P<0.05). Conclusion Auricular acupoint plaster therapy combined with percutaneous acupoint electrical stimulation can effectively relieve the pain of patients with acute renal colic and reduce the adverse reactions caused by the use of analgesics.
		2022 Vol. 29 (21): 127-129 [Abstract] ( 28 ) HTML (1 KB) PDF (443 KB) ( 60 )

	130	Application of time management combined with node control nursing management in inpatients in high altitude medical center
		ZHAO Yanhong； SANG Gari
		Objective To explore the clinical effect of applying time management combined with node control nursing management in high altitude medical centers. Methods A total of 160 inpatients in Naqu People′s Hospital from April 2019 to April 2020 were selected as the research subjects. They were divided into the observation group and the control group by random number table method, with 80 cases in each group. The nurses without cross-over during the same period were divided into the observation group and the control group, with 37 cases in each group. In the observation group, time management combined with node control nursing management was used, while in the control group, routine care was used. The incidence of nursing adverse events, satisfaction rate of the patients, time management tendency scale score and Maslach Burnout Inventory (Human Services Survey) score of nursing staff in the two groups were compared. Results The total incidence of adverse nursing events in the observation group (1.25%) was lower than that in the control group (11.25%), and the patient satisfaction rate (95.00%) was higher than that in the control group (71.25%), the differences were statistically significant (P<0.05). The scores of goal setting, time arrangement, time control and disorder tendency in the observation group were higher than those in the control group, and the differences were statistically significant (P<0.05). The scores of emotional exhaustion and depersonalization in the observation group were lower than those in the control group, and the score of personal accomplishment was higher than that in the control group, the differences were statistically significant (P<0.05). Conclusion Time management combined with node control nursing management applied to high altitude medical centers has remarkable clinical effect. It can effectively improve the time management tendency and job burnout of nursing staff, increase patient satisfaction, and reduce nursing adverse events, which is worthy of clinical promotion.
		2022 Vol. 29 (21): 130-133 [Abstract] ( 25 ) HTML (1 KB) PDF (576 KB) ( 17 )

	134	Effect of centralized management of traditional Chinese medicine reuse of diagnostic and treatment instruments by disinfection supply center
		LOU Liqiong ； LI Yunxia ； HUANG Zizhen ； LI Shuling ； HU Guofeng ； AO Jieqi ； LONG Han
		Objective To explore the effect of centralized management of traditional Chinese medicine reusable diagnostic and treatment devices in disinfection supply center. Methods A total of 7432 traditional Chinese medicine reusable diagnostic and treatment devices in Jiangxi Provincial People′s Hospital from January to June 2021 were selected as the control group, and 8248 traditional Chinese medicine reusable diagnostic and treatment devices from July to December 2021 were selected as the observation group. In the control group, the reusable diagnosis and treatment instruments were washed and disinfected with flowing water in the department, then cleaned with flowing water and dried for later use. The needles and instruments were self-packaged and sent to the disinfection supply center for sterilization. In the observation group, the reusable medical instruments were collected to the disinfection supply center and processed according to the procedures of classification, cleaning, disinfection, packaging, sterilization, storage and distribution. The qualified rate of cleaning, functional damage rate and clinical department satisfaction of traditional Chinese medicine reusable diagnostic and treatment instruments were compared between the two groups. Results The qualified rate of traditional Chinese medicine reusable diagnosis and treatment devices in the observation group (98.16%) was higher than that in the control group (91.52%), and the difference was statistically significant (P<0.05). The functional damage rate of traditional Chinese medicine reusable diagnostic and treatment devices in the observation group (0.18%) was lower than that in the control group (1.17%), and the difference was statistically significant (P<0.05). The total clinical department satisfaction of the observation group (98.33%) was higher than that of the control group (85.67%), and the difference was statistically significant (P<0.05). Conclusion The reprocessing quality of traditional Chinese medicine reprocessing equipment is improved, the damage rate of the equipment is reduced, the satisfaction of the department is improved, and the patient safety is guaranteed.
		2022 Vol. 29 (21): 134-137 [Abstract] ( 27 ) HTML (1 KB) PDF (610 KB) ( 56 )

	138	Discussion and reflection on the integration of the Communist Party of China construction and professional work in public hospitals under the new situation
		SHEN Peiying
		As the main body of China′s medical service system, public hospitals are the fresh force of the health front led by the Communist Party of China and an important window to serve the people. Public hospitals also undertake the important responsibility of implementing the Communist Party of China′s health policy and protecting people′s life and health. In recent years, the hospitals have actively implemented the spirit of the Communist Party of China central committee on strengthening party building in public hospitals and integrates the Communist Party of China building work into all aspects of hospital work. This paper expounds the necessity of strengthening the Communist Party of China construction of public hospitals and promoting the integration of the Communist Party of China construction and professional work in the new period from the perspectives of deepening the reform of public hospitals, establishing modern hospital management system and developing hospital itself. This paper analyzes the problems and reasons existing in the integration of the Communist Party of China construction in hospitals and also discusses the strengthen the ideological and political construction, organizational construction, system construction, perfect organizational structure, perfect system and mechanism. This paper puts forward the ways and methods of integrating the Communist Party of China construction and business in public hospitals under modern hospital management system.
		2022 Vol. 29 (21): 138-141 [Abstract] ( 26 ) HTML (1 KB) PDF (0 KB) ( 13 )

	142	Application and effect of detail management in the population of healthy physical examination
		CHANG Ye
		Objective To explore the application effect of detail management in the population of healthy physical examination. Methods A total of 88 persons underwent physical examination in Department of Health Medicine of General Hospital of the Northern Theater of the Chinese People′s Liberation Army from September 2020 to September 2021 were selected as the research objects, and they were divided into the reference group and the experimental group according to the random number table method, with 44 cases in each group. The reference group received routine physical examination management, and the experimental group received detail management on the basis of the reference group. The waiting time and satisfaction rate were compared between the two groups. Results The waiting time of blood drawing, routine urine test, electrocardiogram and internal and external examination in the experimental group were shorter than those in the control group, and the differences were statistically significant (P<0.05). The total satisfaction rate of the experimental group was higher than that of the reference group, and the difference was statistically significant (P<0.05). Conclusion The use of detail management in physical examination can shorten the waiting time for various examinations, shorten the distance between doctors and patients, and improve the satisfaction rate. It is worth popularizing and applying.
		2022 Vol. 29 (21): 142-144 [Abstract] ( 24 ) HTML (1 KB) PDF (569 KB) ( 37 )

	145	Practice and exploration of promoting the construction of research hospital from the perspective of hospital management
		MENG Sha
		This paper analyzes the bottleneck problems encountered in the innovation and development of governmental hospitals, such as less overall coordination and innovation of the whole hospital, small proportion of outstanding talents, lack of concept of achievement transformation, professional development obstacles of full-time research doctors, and weak information construction. Taking the development and construction of Beijing Youan Hospital, Capital Medical University as an example, comprehensively analyzes how to strengthen the research and innovation function and promote the construction process of research and innovation hospital from management aspects. Such as organizational leadership, fund investment, performance management, scientific research management, platform construction, research ward construction, personnel management and information construction. The innovation ability of hospitals is an important factor that determines the future development prospect of the hospital, which needs to be guided and promoted from a strategic perspective. We should not only look at the bottleneck problems in the transformation and development of hospitals with scientific methods and development perspective, but also have the courage to reform, optimize management, highlight discipline construction, promote the overall coordinated development and innovation of hospitals, and continuously promote the construction of research hospitals.
		2022 Vol. 29 (21): 145-148转160 [Abstract] ( 29 ) HTML (1 KB) PDF (970 KB) ( 179 )

	149	Thinking and exploration of integrating curriculum ideology and politics into stomatology teaching
		PENG Qian； WANG Yuehong； CAO Qiong；PAN Hao； LIU Binjie
		With the vigorous development of education in our country, the classroom teaching in colleges and universities in the new era has changed from the previous education mode centered on knowledge transmission to all-round humanistic quality education. While emphasizing professional knowledge education, ideological and political education is gradually being strengthened. One of the most effective ways to carry out ideological and political education for medical students in colleges and universities in the new era is "curriculum education". In order to promote the development of stomatological medical personnel and to cultivate stomatological medical workers in line with the needs of the times, it is crucial to introduce curriculum ideological and political education to stomatological teaching and talent cultivation. Based on analysis of deficiencies of ideological and political education in the current curriculum teaching of stomatology students, such as unsystematic ideological and political teaching content, clinical teachers′ weak consciousness of ideological and political education, students′ inadequate interest in ideological and political education, and incomplete construction of curriculum ideological and political material database, this paper is focused on exploring the unification of goals of value and imparting knowledge in teaching stomatology, exploiting ideological and political education resources, and establishing clear teaching objectives. Guided by "curriculum ideology and politics", it proposes to make reform of teaching content, with innovation of teaching methods, development of assessment and evaluation system, building of curriculum ideological and political material library, and integration of ideological and political education into the whole process of theoretical and practical teaching. These measures will be helpful to cultivation of stomatology talents with noble medical ethics, excellent professional skills, strong sense of responsibility and love in the new era, contributing to the development of medical cause in China.
		2022 Vol. 29 (21): 149-152 [Abstract] ( 29 ) HTML (1 KB) PDF (641 KB) ( 286 )

	153	Application effect of integrating curriculum ideology and politics into internal medicine teaching
		LI Yan； LI Suhua； CHAI Rangcuo； WANG Xuehong
		Objective Starting from the ideological and political construction of internal medicine curriculum of clinical medicine specialty, this paper discusses the application effect of integrating curriculum ideological and political into internal medicine teaching. Methods A total of 56 medical students majoring in clinical medicine who rotated in the Department of Gastroenterology, the Affiliated Hospital of Qinghai University from September to December 2021 were selected as research subjects. They were divided into observation group and control group according to the parity of the last position of their student ID, with 28 students in each group. Both groups were taught by an experienced lecturer on the internal medicine of the digestive disease ulcerative colitis. The control group carried out routine teaching, while the observation group integrated curriculum ideological and political teaching. After class, the teaching effects of the two groups were evaluated by questionnaire survey and student interview. Results There were no significant differences between the two groups in terms of professional curriculum knowledge mastery, curriculum knowledge practicability, scientific research spirit feeling and overall teaching evaluation (P>0.05). The proportion of those who felt the importance of medical ethics and classroom positive energy in the observation group was higher than that in the control group, and the difference was statistically significant (P<0.05). The classroom score of observation group was higher than that of control group, and the difference was statistically significant (P<0.05). According to students′ interview feedback, ideological and political teachers of the course were more enthusiastic in teaching, the classroom atmosphere was more active, and they feel a strong sense of professional honor and mission. Conclusion Promoting the ideological and political construction of medical courses is helpful to improve the moral awareness and ability of teachers. Promote medical students to the spirit of caring for patients, the pursuit of science spirit, dedication to medicine, help medical students to establish the correct value orientation.
		2022 Vol. 29 (21): 153-156 [Abstract] ( 36 ) HTML (1 KB) PDF (758 KB) ( 41 )

	157	Construction of evaluation indexes for clinical practice ability of higher vocational nursing students using Delphi method
		LAN Ding； LIU Ying； YANG Jing； ZHOU Na； LIU Chunjiang ； CHE Xiaowen ； ZHANG Yi
		Objective To construct a scientific and feasible objective structure clinical examination (OSCE) evaluation indexes for clinical practice ability of higher vocational nursing students. Methods Based on literature review, the Delphi expert inquiry method was used for two rounds of expert consultation and finally determined the OSCE evaluation indexes for clinical practice ability of higher vocational nursing students. Results The OSCE evaluation indexes for clinical practice ability of higher vocational nursing students included 6 first-level indicators, which were health history collection, physical and mental assessment, skill operation, health education, critical thinking and professional accomplishment, involving 25 second-level indicators. The expert consultation is representative and credible. Conclusion The OSCE evaluation indexes for clinical practice ability of higher vocational nursing students can be used to evaluate the clinical practice ability and provide reference for higher vocational nursing teaching reform.
		2022 Vol. 29 (21): 157-160 [Abstract] ( 27 ) HTML (1 KB) PDF (626 KB) ( 111 )

	161	Application effect of team-based learning and case-based learning in pediatric dentistry at vocational college
		GE Bing ； ZHU Wenwei； LI Bei ；CUI Hongmei
		Objective To discuss the teaching effect of team-based learning (TBL) and case-based learning (CBL) in pediatric dentistry at vocational colleges. Methods Sixty students in department of stomatology at Suzhou Vocational Health College were selected as research objects, they were divided into TBL group and CBL group by lottery. TBL group was taught with TBL method, and the CBL group was taught with CBL method. The test scores and questionnaire survey results of the two groups were compared. Results There was no significant difference in mid-term exam scores between the two groups (P>0.05). The scores of final exam, practical training, and overall evaluation in the CBL group were higher than those in the TBL group, and the differences were statistically significant (P<0.05). There were no significant differences in the satisfactions of course content, assessment methods, course resources, and learning environment between the two groups (P>0.05). The satisfaction of teaching mode in the CBL group was higher than that in the TBL group, and the difference was statistically significant (P<0.05). Conclusion The CBL method achieves satisfactory teaching effect, and can be applied in college students.
		2022 Vol. 29 (21): 161-164转169 [Abstract] ( 23 ) HTML (1 KB) PDF (646 KB) ( 30 )

	165	Design of "course certificate integration" program for maternal and infant nursing vocational skills certificate and higher vocational midwifery major
		WANG Qianqian； XIE Xiaofang ； WANG Qiaoli
		Under the background of the pilot program of the "academic certificate+vocational skill level certificate" system launched in vocational colleges and application-oriented undergraduate colleges and universities, as the second batch of vocational skills certificates issued by the Ministry of Education, the maternal and infant nursing vocational skills certificate has opened up a new situation for improving the quality of maternal and infant nursing talents. As the first batch of pilot units, Heze Medical College should organically integrate the content of the maternal and infant nursing skills certificate into the teaching of professional courses, so that vocational ability training and the curriculum system are closely integrated. This paper expounds the "course certificate integration" scheme of maternal and infant nursing and vocational midwifery majors from four aspects: integration of overall planning, selection of key teaching entry points, implementation of teaching plans, and adjustment of talent training plans, and the key points of "course certificate integration" include: reconstructing the curriculum system, developing loose-leaf teaching materials, using flexible and diverse teaching methods, implementing multiple assessments, integrating humanistic care, and enriching the "double-qualified" teacher team. This article explores and practices the "course certificate integration" scheme of maternal and infant nursing skills certificate and higher vocational midwifery major, assists the construction of midwifery major, and cultivates compound and skilled talents for the society, at the same time, it provides a reference for the integration of other vocational skills certificates and professional courses.
		2022 Vol. 29 (21): 165-169 [Abstract] ( 24 ) HTML (1 KB) PDF (735 KB) ( 41 )

	170	Effect of total process management on the incidence of arrhythmia in patients with mental disorders undergoing modified electro-convulsive therapy
		DENG Hongqi ； YAO Yu
		Objective To explore the effect of total process management on the incidence of arrhythmia in patients with mental disorders undergoing modified electro-convulsive therapy (MECT). Methods Ninety patients with mental disorders underwent MECT in the Third People′s Hospital of Shangrao City from January to June 2021 were selected as research objects. They were divided into control group and observation group by random number table method, with 45 cases in each group. The control group received routine nursing intervention, and the observation group received total process management nursing intervention. The incidence of arrhythmia and adverse events, nursing cooperation and nursing satisfaction were compared between the two groups. Results There were no significant differences between the two groups in the incidence of single ventricular premature beat, bigeminy, trigeminy, ventricular tachycardia, QTc interval prolongation and cardiac arrest at 5, 10 and 30 min after treatment (P>0.05). The total incidence of adverse events such as prolonged apnoea time, dysmnesia, irritability, dizziness and discomfort, large-area rash in regiones pectoris anterior and excessive respiratory secretions in the observation group was lower than that in the control group, the difference was statistically significant (P<0.05). Patients cooperating with nurses in the observation group were more than those in the control group, the differences were statistically significant (P<0.05). Treatment time and waiting time in the observation group were shorter than those in the control group, the number of times of risk events in the observation group was less than that in the control group, the differences were statistically significant (P<0.05). The nursing satisfaction in the observation group was higher than that in the control group, the difference was statistically significant (P<0.05). Conclusion Total process management can effectively reduce the incidence rates of arrhythmia and adverse events in patients with mental disorders during MECT, and improve their nursing cooperation and nursing satisfaction.
		2022 Vol. 29 (21): 170-173 [Abstract] ( 26 ) HTML (1 KB) PDF (595 KB) ( 30 )

	174	Effect of music therapy on preoperative negative emotion and psychological resilience of patients with gynecological malignancy
		ZHANG Panpan； CHEN Chen； WU Haibo； CUI Xiaohua
		Objective To investigate the effect of music therapy combined with routine nursing on preoperative negative emotion and psychological resilience of patients with gynecological malignancy. Methods A total of 200 patients undergoing gynecological malignant tumor surgery in Women′s Hospital of Nanjing Medical University from January 2019 to December 2020 were selected as the research subjects. According to random number table method, the patients were divided into routine nursing group (n=100) and music therapy group (n=100). Routine nursing group adopted routine nursing, and music therapy group combined with music therapy on the basis of routine nursing. Self-rating anxiety scale (SAS) score, heart rate and blood pressure fluctuation, psychological resilience score and patient satisfaction score were compared between the two groups before and after intervention. Results After intervention, systolic pressure, diastolic pressure, and heart rate of music therapy group were lower than those of conventional nursing group, the differences were statistically significant (P<0.05). At the same time, there were no significant differences in systolic pressure, diastolic pressure, and heart rate of conventional nursing group before and after intervention (P>0.05), heart rate and blood pressure were more stable. SAS score of music therapy group was lower than that of routine nursing group after intervention, and the difference was statistically significant (P<0.05). After intervention, the mental resilience score of music therapy group was higher than that of conventional nursing group, and the difference was statistically significant (P<0.05). The satisfaction score of patients in music therapy group was higher than that in conventional nursing group, and the difference was statistically significant (P<0.05). Conclusion Music therapy combined with routine nursing can significantly improve patient anxiety, reduce stress response, enhance psychological resilience, improve perioperative nursing service quality and patient safety, improve patient satisfaction.
		2022 Vol. 29 (21): 174-177转181 [Abstract] ( 32 ) HTML (1 KB) PDF (619 KB) ( 75 )

	178	Application value of positive psychological intervention based on PERMA model in patients with advanced cervical cancer
		OUYANG Aiyu； SUN Yan； YU Caixia
		Objective To explore the effect of positive psychological intervention based on PERMA model in patients with advanced cervical cancer. Methods A total of 64 patients with advanced cervical cancer treated in Jiujiang Third People′s Hospital from February 2020 to February 2022 were selected as research objects, they were divided into control group and observation group according to random number table method, with 32 cases in each group. The control group received routine nursing, while the observation group received positive psychological intervention based on PERMA model on the basis of the control group. Both groups received continuous nursing for 4 weeks. Post traumatic stress disorder, subjective well-being, quality of life and nursing satisfaction were compared between the two groups. Results After the intervention, the scores of repeated traumatic experience symptoms, emotional numbness and avoidance symptoms and irritable symptoms caused by excessive alertness in the PTSD checklist-civilian version (PCL-C) in the observation group were lower than those in the control group, the differences were statistically significant (P<0.05). After the intervention, the scores of general well-being scale (GWB) and quality of life questionnare-core 30 (QLQ-C30) in the observation group were higher than those in the control group, the differences were statistically significant (P<0.05). The nursing satisfaction in observation group was 93.75%, which was higher than 75.00% in the control group, the difference was statistically significant (P<0.05). Conclusion Positive psychological intervention based on PERMA model can reduce post-traumatic stress disorder in patients with advanced cervical cancer, enhance patients′ subjective well-being, promote the improvement of quality of life, and improve nursing satisfaction.
		2022 Vol. 29 (21): 178-181 [Abstract] ( 31 ) HTML (1 KB) PDF (606 KB) ( 96 )

	182	Application effect of respiratory function training combined with rehabilitation nursing on the recovery of patients with tuberculous empyema after operation
		QIU Dandan； HU Xuedan； SHI Xiangli
		Objective To explore the effect of respiratory function training combined with rehabilitation nursing in the recovery of patients with tuberculous empyema after surgery. Methods A total of 40 patients with tuberculous empyema after surgery admitted to Jiangxi Chest Hospital from January 2020 to March 2021 were selected as the study subjects, they were divided into control group (20 cases) and observation group (20 cases) according to random number table method. Patients in the control group were treated with routine nursing, and patients in the observation group were treated with respiratory function training and rehabilitation nursing. Lung complications, pain score, quality of life and nursing satisfaction were compared between the two groups. Results Before nursing, there was no significant difference in pain scores between the two groups (P>0.05). After nursing, the pain score of both groups was lower than that before nuring, and the pain score of observation group was lower than that of control group, the difference was statistically significant (P<0.05). The nursing satisfaction of observation group was higher than that of control group, the difference was statistically significant (P<0.05). The scores of quality of life in the observation group were higher than those in the control group, with statistical significances (P<0.05). The total incidence of complications in the observation group was lower than that in the control group, the difference was statistically significant (P<0.05). Conclusion Respiratory function training combined with rehabilitation nursing program is effective for patients with tuberculous empyema after operation.
		2022 Vol. 29 (21): 182-185 [Abstract] ( 26 ) HTML (1 KB) PDF (620 KB) ( 71 )

	186	Application effect of diversified nursing in children with amblyopia
		LI Lilan ； NI Lianhong； LIU Huiru
		Objective To explore the effect of diversified nursing in the nursing of children with amblyopia. Methods From February 2020 to April 2021, 580 children with amblyopia admitted to the Department of Ophthalmology, the 910th Hospital of the Joint Support Force of the Chinese People′s Liberation Army were selected as research subjects. They were divided into control group and study group according to random number table method, with 290 cases and 290 eyes in each group. The control group used routine nursing. The study group used diversified care. The guidance effect and parents′ satisfaction were compared between the two groups. Results The total effective rate of moderate and severe amblyopia in the study group was higher than that in the control group, with statistical significance (P<0.05). There was no significant difference in the total effective rate of mild amblyopia nursing between the two groups (P>0.05). The total satisfaction of parents in the study group was higher than that in the control group, and the difference was statistically significant (P<0.05). Conclusion Diversified nursing guidance is adopted in the nursing of amblyopia in children, and the satisfaction of parents is higher. The effectiveness of pediatric amblyopia nursing is very significant, especially for moderate and severe amblyopia. Diversified nursing instruction has excellent nursing value and is worthy of clinical promotion.
		2022 Vol. 29 (21): 186-188转192 [Abstract] ( 26 ) HTML (1 KB) PDF (0 KB) ( 12 )

	189	Effect of airway cluster intervention model on tube indwelling time and the incidence of complications in patients undergoing tracheotomy
		DING Lihua ； XU Hui ； HE Yuanfang
		Objective To investigate the effect of airway cluster intervention model on tube indwelling time and the incidence of complications in patients undergoing tracheotomy. Methods This study retrospectively reviewed 80 patients who underwent tracheotomy in the Traditional Chinese Medicine Hospital of Shangrao City from March 2017 to May 2021. The patients were divided into control group and observation group according to different nursing modes, with 40 cases in each group. The control group received traditional airway management and nursing, while the observation group received airway cluster intervention. The recovery, nursing satisfaction score and total incidence of complications during treatment were compared between the two groups. Results The tube indwelling time and hospital stay of observation group were shorter than those of control group, and the Glasgow coma scale (GCS) score of observation group was higher than that of control group, the differences were statistically significant (P<0.05). The satisfaction scores of basic nursing, critical care, nursing attitude and nursing operation in observation group were higher than those in control group, and the differences were statistically significant (P<0.05). The total incidence of complications in observation group was lower than that in control group, and the difference was statistically significant (P<0.05). Conclusion Airway cluster intervention model can shorten tube indwelling time, coma duration and hospital stay, and prevent complications in patients undergoing tracheotomy.
		2022 Vol. 29 (21): 189-192 [Abstract] ( 28 ) HTML (1 KB) PDF (619 KB) ( 53 )

	193	Application effect of solution-focused brief group intervention program in patients with acute leukemia
		TANG Juan；ZHAI Xiao
		Objective To explore the application effect of solution-focused brief group intervention program in patients with acute leukemia. Methods A total of 66 patients with acute leukemia admitted to Shunde Hospital of Southern Medical University from January 2020 to November 2021 were selected as the study subjects, they were divided into control group and observation group according to random number table method, with 33 cases in each group. The control group received routine psychological nursing, and the observation group received short-term group intervention program based on focus solution. The scores of hospital anxiety and depression scale-anxiety (HADS-A), hospital anxiety and depression scale-depression (HADS-D), general self-effieaey sense scale (GSES) and functional assessment of cancer therapy (FACT-G) were compared between two groups before and after intervention. Results There were no significant differences in HADS-A, HADS-D, GSES and FACT-G scores between the two groups before intervention (P>0.05). After intervention, HADS-A and HADS-D scores in the observation group were lower than those in the control group, GSES score, all dimensions and total score of FACT-G were higher than those of the control group, the differences were statistically significant (P<0.05). Conclusion The implementation of solution-focused brief group intervention in patients with acute leukemia can significantly alleviate the anxiety and depression of patients, improve self-efficacy and quality of life, and has high clinical value.
		2022 Vol. 29 (21): 193-196 [Abstract] ( 27 ) HTML (1 KB) PDF (595 KB) ( 40 )

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