小儿咳喘颗粒联合布地奈德雾化与单纯雾化治疗儿童支气管哮喘并发肺部感染的疗效对比

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Abstract Objective To compare the curative effect of Xiaoer Kechuan Granule combined with Budesonide Atomization and simple atomization in the treatment of bronchial asthma complicated with pulmonary infection. Methods A total of 80 cases of children with bronchial asthma complicated with pulmonary infection admitted to Jiangxi Children′s Hospital from December 2019 to September 2021 were selected as the research objects, they were divided into the observation group and the control group according to random number table method, with 40 cases in each group. The control group was given Budesonide Atomization treatment, and the observation group was given Xiaoer Kechuan Granule on the basis of the above. The clinical efficacy, symptom improvement (duration of dyspnea, disappearance time of lung moist rales, disappearance time of lung wheezing and cough duration), inflammatory level (tumor necrosis factor-α [TNF-α], interleukin-6 [IL-6]) and the incidence of adverse reactions were compared between the two groups. Results The total effective rate of the observation group was higher than that of the control group, and the difference was statistically significant (P＜0.05). The disappearance time of lung moist rales, disappearance time of lung wheezing and cough duration in the observation group were shorter than those in the control group, and the differences were statistically significant (P＜0.05). The level of IL-6 in the observation group after treatment was lower than that before treatment and that in the control group after treatment, and the differences were statistically significant (P＜0.05). There was no significance in the total incidence of adverse reactions between two groups (P＞0.05). Conclusion Xiaoer Kechuan Granule combined with Budesonide Atomization can improve the clinical efficacy and reduce the level of inflammation in children with bronchial asthma complicated with pulmonary infection, which is safe and worthy of clinical attention.

Key words： Xiaoer Kechuan Granule Budesonide Bronchial asthma Lung infection

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