妊娠早期行胰岛素治疗对妊娠糖尿病患者血糖控制效果及妊娠结局的影响

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Abstract Objective To investigate the clinical effect of insulin therapy on gestational diabetes mellitus (GDM) in early pregnancy and its effect on pregnancy outcome. Methods A total of 300 patients with GDM treated in Panyu District Sixth People′s Hospital of Guangzhou from May 2019 to May 2021 were selected as the research objects. They were divided into the control group and the observation group according to ranom number table method, with 150 cases in each group. The control group was treated with insulin after 32 weeks of pregnancy, and the observation group was treated with insulin before 32 weeks of pregnancy. Both groups continued medication until delivery. The clinical efficacy, blood glucose control effect, pregnancy outcome and hypoglycemia were compared between the two groups. Results The total effective rate of the observation group was higher than that of the control group, the difference was statistically significant (P＜0.05). The fasting blood glucose (FPG), 2 hours postprandial blood glucose (2 h PG), mean of daily differences (MODD) and 24 hours mean amplitude of glycemic excursions (MAGE) in the observation group before delivery were lower than those in the control group, and the differences were statistically significant (P＜0.05). The incidence of adverse pregnancy outcomes in the observation group was lower than that in the control group, the difference was statistically significant (P＜0.05). There was no significant difference in the incidence of hypoglycemia between the two groups (P＞0.05). Conclusion Insulin therapy in early pregnancy is more effective in GDM, which can stably control blood glucose level and reduce adverse pregnancy outcomes. It is safe and reliable.

Key words： Gestational diabetes mellitus Insulin Blood glucose control effect Pregnancy outcome Adverse reaction

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CUI Pingli. Effect of insulin therapy on blood glucose control and pregnancy outcome in patients with gestational diabetes mellitus during early pregnancy[J]. 中国当代医药, 2022, 29(21): 92-94转98.

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https://www.dangdaiyiyao.com/EN/ OR https://www.dangdaiyiyao.com/EN/Y2022/V29/I21/92

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