Notch信号在颅颌面骨骼发育及骨代谢中的作用

Abstract
Figure/Table
References (44)
Related Citation (12)

Download: PDF (518 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Due to its special anatomical structure, cranialmaxillofacial bones have various development modes, including endochondral, intramembrane and suture osteogenesis, in which chondrocytes and osteoblasts differentiated from mesenchymal cells play a key role. Under the action of osteoblast-osteoclast coupling bone metabolism, the developed cranialmaxillofacial bones will continue to grow and rebuild, and abnormal bone metabolism will lead to problems such as bone remodeling imbalance, bone absorption and bone healing disorders. In recent years, Notch signaling has received more and more attention for its important role in cranialmaxillofacial bone development and bone metabolism. Notch signal, as a classical signal related to development, affects the differentiation and function of bone development and metabolism related cells such as mesenchymal cells, chondrocytes, osteoblasts and osteoclasts. Cranialmaxillofacial bones with special development patterns, such as condyle, cranial suture and alveolar bone, have also been revealed to be closely associated with Notch signaling. This article reviews the role of Notch signaling in cranialmaxillofacial bone development and bone metabolism, in order to provide new ideas for the prevention and treatment of related diseases.

Key words： Notch signaling Craniomaxillofacial bone Bone development Bone metabolism

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	TAN Hao
	XU Wenjie
	HE Xinyi
	ZHENG Leilei

Cite this article:

TAN Hao,XU Wenjie,HE Xinyi, et al. Role of Notch signaling in craniomaxillofacial bone development and bone metabolism[J]. 中国当代医药, 2022, 29(21): 31-35.

URL:

https://www.dangdaiyiyao.com/EN/ OR https://www.dangdaiyiyao.com/EN/Y2022/V29/I21/31

[1]	Hong L，Sun H，Amendt B.Microrna function in craniofacial bone formation，regeneration and repair[J].Bone，2021，144：115789.
[2]	Shah H，Jones R，Borrelli M，et al.Craniofacial and long bone development in the context of distraction osteogenesis[J].Plast Reconstr Surg，2021，147（1）：54e-65e.
[3]	Pakvasa M，Haravu P，Boachie-Mensah M，et al.Notch signaling：Its essential roles in bone and craniofacial development[J].Genes Dis，2021，8（1）：8-24.
[4]	Siebel C，Lendahl U.Notch signaling in development，tissue homeostasis，and disease[J].Physiol Rev，2017，97（4）：1235-1294.
[5]	Zanotti S，Canalis E.Notch regulation of bone development and remodeling and related skeletal disorders[J].Calcif Tissue Int，2012，90（2）：69-75.
[6]	Ballhause T，Jiang S，Baranowsky A，et al.Relevance of notch signaling for bone metabolism and regeneration[J].Int J Mol Sci，2021，22（3）：1325.
[7]	Ruscitto A，Scarpa V，Morel M，et al.Notch regulates fibrocartilage stem cell fate and is upregulated in inflammatory tmj arthritis[J].J Dent Res，2020，99（10）：1174-1181.
[8]	Kamalakar A，McKinney J，Salinas Duron D，et al.Jagged1 stimulates cranial neural crest cell osteoblast commitment pathways and bone regeneration independent of canonical notch signaling[J].Bone，2021，143：115657.
[9]	Djinic Krasavcevic A，Nikolic N，Mijailovic I，et al.Impact of notch signalling molecules and bone resorption regulators on clinical parameters in periodontitis[J].J Periodontal Res，2021，56（1）：131-138.
[10]	Kopan R，Ilagan M.The canonical notch signaling pathway：Unfolding the activation mechanism[J].Cell，2009，137（2）：216-233.
[11]	Bray S，Gomez-Lamarca M.Notch after cleavage[J].Curr Opin Cell Biol，2018，51：103-109.
[12]	Karlsson C，Lindahl A.Notch signaling in chondrogenesis[J].Int Rev Cell Mol Biol，2009，275：65-88.
[13]	Dong Y，Jesse A，Kohn A，et al.Rbpjkappa-dependent notch signaling regulates mesenchymal progenitor cell proliferation and differentiation during skeletal development[J].Development，2010，137（9）：1461-1471.
[14]	Mead T，Yutzey K.Notch pathway regulation of chondrocyte differentiation and proliferation during appendicular and axial skeleton development[J].Proc Natl Acad Sci U S A，2009，106（34）：14420-14425.
[15]	Song H，Park KH.Regulation and function of sox9 during cartilage development and regeneration[J].Semin Cancer Biol，2020，67（Pt 1）：12-23.
[16]	Rutkowski T，Kohn A，Sharma D，et al.Hes factors regulate specific aspects of chondrogenesis and chondrocyte hypertrophy during cartilage development[J].J Cell Sci，2016，129（11）：2145-2155.
[17]	Hinton R，Serrano M，So S.Differential gene expression in the perichondrium and cartilage of the neonatal mouse temporomandibular joint[J].Orthod Craniofac Res，2009，12（3）：168-177.
[18]	Serrano M，So S，Hinton R.Roles of notch signalling in mandibular condylar cartilage[J].Arch Oral Biol，2014，59（7）：735-740.
[19]	Lan L，Jiang Y，Zhang W，et al.Expression of notch signaling pathway during osteoarthritis in the temporomandibular joint[J].J Craniomaxillofac Surg，2017，45（8）：1338-1348.
[20]	Ishii M，Sun J，Ting M，et al.The development of the calvarial bones and sutures and the pathophysiology of craniosynostosis[J].Curr Top Dev Biol，2015，115：131-156.
[21]	D′Amico A，Perillo T，Cuocolo R，et al.Neuroradiological findings in alagille syndrome[J].Br J Radiol，2021，95（1129）：20201241.
[22]	Yen H，Ting M，Maxson R.Jagged1 functions downstream of twist1 in the specification of the coronal suture and the formation of a boundary between osteogenic and non-osteogenic cells[J].Dev Biol，2010，347（2）：258-270.
[23]	Lenton K，Nacamuli R，Wan D，et al.Cranial suture biology[J].Curr Top Dev Biol，2005，66：287-328.
[24]	Liu X，Zhang C，Jing J，et al.Role of notch signaling in the physiological patterning of posterofrontal and sagittal cranial sutures[J].J Craniofac Surg，2017，28（6）：1620-1625.
[25]	Ponzetti M，Rucci N.Osteoblast differentiation and signaling：Established concepts and emerging topics[J].Int J Mol Sci，2021，22（13）：6651.
[26]	Regan J，Long F.Notch signaling and bone remodeling[J].Curr Osteoporos Rep，2013，11（2）：126-129.
[27]	Canalis E，Parker K，Feng J，et al.Osteoblast lineage-specific effects of notch activation in the skeleton[J].Endocrinology，2013，154（2）：623-634.
[28]	Engin F，Yao Z，Yang T，et al.Dimorphic effects of notch signaling in bone homeostasis[J].Nat Med，2008，14（3）：299-305.
[29]	Zhou Y，Li J，Zhou K，et al.The methylation of notch1 promoter mediates the osteogenesis differentiation in human aortic valve interstitial cells through wnt/β-catenin signaling[J].J Cell Physiol，2019，234（11）：20366-20376.
[30]	Yorgan T，Vollersen N，Riedel C，et al.Osteoblast-specific notch2 inactivation causes increased trabecular bone mass at specific sites of the appendicular skeleton[J].Bone，2016， 87：136-146.
[31]	Dou X，Park W，Lee S，et al.Loss of notch3 signaling enhances osteogenesis of mesenchymal stem cells from mandibular torus[J].J Dent Res，2017，96（3）：347-354.
[32]	Chakravorty N，Hamlet S，Jaiprakash A，et al.Pro-osteogenic topographical cues promote early activation of osteoprogenitor differentiation via enhanced TGFβ，wnt，and notch signaling[J].Clin Oral Implants Res，2014，25（4）：475-486.
[33]	Sun Y，Li J，Xie X，et al.Recent advances in osteoclast biological behavior[J].Front Cell Dev Biol，2021，9：788680.
[34]	Bai S，Kopan R，Zou W，et al.Notch1 regulates osteoclastogenesis directly in osteoclast precursors and indirectly via osteoblast lineage cells[J].J Biol Chem，2008，283（10）：6509-6518.
[35]	Fukushima H，Nakao A，Okamoto F，et al.The association of notch2 and NF-κB accelerates rankl-induced osteoclastogenesis[J].Mol Cell Biol，2008，28（20）：6402-6412.
[36]	Kang J，Kang N，Yang Y，et al.The role of ca-nfatc1 signaling and its modulation on osteoclastogenesis[J].Int J Mol Sci，2020，21（10）：3646.
[37]	Vollersen N，Hermans-Borgmeyer I，Cornils K，et al.High bone turnover in mice carrying a pathogenic notch2 mutation causing hajdu-cheney syndrome[J].J Bone Miner Res 2018，33（1）：70-83.
[38]	Huang X，Xie M，Xie Y，et al.The roles of osteocytes in alveolar bone destruction in periodontitis[J].J Transl Med，2020，18（1）：479.
[39]	Mijailovic I，Nikolic N，Djinic A，et al.The down-regulation of Notch1 signaling contributes to the severity of bone loss in aggressive periodontitis[J].J Periodontol，2020，91（4）：554-561.
[40]	付海标，闫俊杰.慢性牙周炎患者外周血单核细胞notch1 mRNA的表达及与疾病严重程度的相关性[J].中国现代医学杂志，2020，30（16）：28-32.
[41]	Milinkovic I，Djinic Krasavcevic A，Nikolic N，et al.Notch downregulation and inflammatory cytokines and rankl overexpression involvement in peri-implant mucositis and peri-implantitis：A cross-sectional study[J].Clin Oral Implants Res，2021，32（12）：1496-1505.
[42]	Manokawinchoke J，Sumrejkanchanakij P，Pavasant P，et al.Notch signaling participates in TGF-β-induced sost expression under intermittent compressive stress[J].J Cell Physiol，2017，232（8）：2221-2230.
[43]	Manokawinchoke J，Pavasant P，Osathanon T.Intermittent compressive stress regulates notch target gene expression via transforming growth factor-β signaling in murine pre-osteoblast cell line[J].Arch Oral Biol，2017，82：47-54.
[44]	杨亚.大鼠正畸牙移动过程中notch1信号通路参与牙槽骨吸收改建的初步研究[D].重庆：重庆医科大学，2019.