Objective To evaluate the clinical effect of the formulas with Radix Notoginseng and Rhizoma Bletillae in the treatment of peptic ulcer (PU). Methods A computer search was conducted for all randomized controlled trials on the treatment of PU with the formulas with Radix Notoginseng and Rhizoma Bletillae in CNKI, VIP, Wanfang, Chinese Biomedical literature, PubMed, Embase and Web of Science databases from self-built database to October 2021.Literature was screened according to inclusion and exclusion criteria and data were extracted.RevMan 5.4 software was used for quality evaluation and meta-analysis of data. Results A total of 9 studies were included, with a total sample of 747 patients, including 379 in experimental group and 368 in control group.The results of meta-analysis showed that the total effective rate of ulcer healing in the experimental group treated with the formulas with Radix Notoginseng and Rhizoma Bletillae was higher than that in the control group treated with western medicine alone (OR=4.33, 95%CI[2.37, 7.89], P＜0.000 01).There was no statistically significant difference in Helicobacter pylori conversion rate between the experimental group and the control group (OR=2.09, 95%CI [0.96, 4.56], P=0.06).There was no significant difference in the incidence of adverse reactions between the experimental group and the control group (OR=3.75, 95%CI [0.30, 47.72], P=0.31).The time of signs disappearance (MD=-2.35, 95%CI [-2.81, -1.89], P＜0.000 01), hospital stay (MD=-3.17, 95%CI [-3.68, -2.66], P＜0.000 01) and time of ulcer recovery (MD=-8.55, 95%CI [-10.69, -6.42],P＜0.000 01) in experimental group were shorter than those in control group. Conclusion The the formulas with Radix Notoginseng and Rhizoma Bletillae combined western medicine treatment of PU the curative effect is superior to western medicine therapy, especially in the recovery phase of the treatment is excellent.

Objective To investigate whether the preoperative peripheral blood neutrophil/lymphocyte ratio (NLR) of pregnant women with acute cervical insufficiency can predict potential histologic chorioamnionitis (HCA). Methods A retrospective analysis was performed on the clinical data of 98 preterm pregnant women who underwent salvage cervical cyclization in Maternal and Child Health Hospital of Fujian Province from January 2016 to December 2020.According to the pathological results of placenta after delivery, they were divided into preterm with HCA group (63 cases) and preterm without HCA group (35 cases).Preoperative peripheral blood inflammation markers and positive rate of cervical secretion culture were compared between the two groups.ROC curve analysis of NLR was conducted to analyze its predictive value to HCA. Results The gestational age of premature rupture of membranes and the gestational age of delivery in preterm with HCA group were lower than those in preterm labor without HCA group, the pregnancy extension days were shorter than those in preterm without HCA group, and the cesarean section rate and neonatal weight were lower than those in preterm without HCA group, the differences were statistically significant (P＜0.05).The positive rate of NLR and cervix microbial culture in preterm with HCA group were higher than those in preterm labor without HCA group, the differences were statistically significant (P＜0.05).ROC curve analysis showed that THE AUC of NLR was 0.726 (P＜0.05), and the optimal cutoff value was 5.61.The sensitivity, specificity, positive predictive value and negative predictive value of NLR were 69.84%, 57.78%, 83.02% and 42.22%, respectively.Kaplan-Meier survival analysis showed that the median length of pregnancy prolonged after cervical cyclization was 53 days in the NLR≥5.61 group, and 63 days in the NLR ＜5.61 group, the difference was statistically significant (P＜0.05). Conclusion Maternal peripheral blood NLR is expected to be an inflammatory marker for predicting potential placental chorioamnionitis in pregnant women with acute cervical insufficiency, and is related to the prolongation of gestational week after rescue cervical cerclage.

Objective To explore the clinical effect of Prunella Granules combined with Methylprednisolone in the treatment of non-lactation mastitis. Methods Forty patients with non-lactation mastitis from May 2018 to January 2021 were selected as the research subjects.They were divided into control group and treatment group by random number table method, with 20 cases in each group.The control group was treated with Methylprednisolone Tablets alone, and the treatment group was treated with Methylprednisolone Tablets plus Prunella Granules.The total response rate,recurrence rate, incidence of adverse reactions, C-reactive protein (CRP), interleukin-6 (IL-6), interleukin-8 (IL-8),tumor necrosis factor-α (TNF-α), immunoglobulin A (IgA), immunoglobulin G (IgG), immunoglobulin M (IgM), CD4+/CD8+ levels before and after treatment were compared between the two groups. Results The curative effect of patients in the treatment group was better than that in the control group, and the difference was statistically significant (P＜0.05).The recurrence rate (0%) in the treatment group was lower than that in the control group (25.00%), and the difference was statistically significant (P＜0.05).The total incidence of adverse reactions in the treatment group (0%) was lower than that in the control group (20.00%), and the difference was statistically significant (P＜0.05).After treatment, the expression levels of CRP, IL-6, IL-8, and TNF-α in the two groups were lower than those before treatment, and the levels of CRP, IL-6, IL-8, and TNF-α in the treatment group were lower than those in the control group, the differences were statistically significant (P＜0.05).After treatment, the levels of IgA, IgG, IgM, CD4+/CD8+ in the treatment group were higher than those in the control group, and the differences were statistically significant (P＜0.05).Conclusion The treatment of non-lactation mastitis patients with Prunella Granules combined with Methylprednisolone can achieve significant effect, reduce inflammatory reaction, improve immune function, control clinical symptoms, it is worth popularizing.

Objective To observe the changes of the clinical indicators and hemodynamics in patients applied to the thoracoscopic radical esophageal malignancy surgery under carbon dioxide pneumothorax in general anesthesia with visual bronchial closure tube or single-lumen tracheal catheter, to evaluate the advantages and safety of anaesthetic method with visual bronchial closure tube in this type of operation. Methods A total of 60 patients who underwent elective thoracoscopic radical esophagectomy in Anyang Tumor Hospital from January 2019 to November 2021 were selected as the research subjects, and they were divided into single-lumen endotracheal tube group (group S) and visual bronchial occlusion tube group (group V) by completely random number table method, with 30 cases in each group.All patients received general anesthesia,in group S,the single-lumen endotracheal tube was intubated into the main trachea.Group V was intubated to 3 cm aove the carina of the main trachea under visualization, after seeing the carina, the occluder cuff was accurately positioned to the bronchial opening under the carina on the affected side.During the operation, mechanical ventilation was suspended at an appropriate time, at the same time carbon dioxide (CO2)gas(3-7 L/min)was slowly filled into the thoracic cavity of the operation side within the specified time,and the intrathoracic pressure was maintained at 3-7 mmHg (1 mmHg=0.133 kPa), in order to collapse the affected lung and achieve onelung ventilation.In group V, the occluder cuff was properly inflated after the lung collapsed on the operation side.Indicators of clinica include Blood pressure (BP), heart rate (HR), pulse blood oxygen saturation (SpO2), central venous pressure (CVP), and peak airway pressure (Paw), end-tidal carbon dioxide partial pressure (PetCO2), and arterial blood gas were collected at 5 min before pneumothorax (T1), 5 min after pneumothorax (T2), 15 min after pneumothorax (T3),30 min after pneumothorax (T4), 60 min after pneumothorax (T5), 100 min after pneumothorax (T6).The CO2 pressure injected into the thoracic cavity of the operation side, CO2 pneumothorax time, operation time, ICU treatment time,hospitalization time, and hospitalization expenses were also observed and studied in the two groups. Results All cases were successfully completed by thoracoscopic operation, significant arrhythmias and severe complications were not found at each time point.The CVP, Paw, PetCO2 on T2, T3, T4, T5 and T6 of the two groups were higher than those of T1,BP, HR, partial pressure of blood oxygen (PaO2) and pH on T2, T3, T4, T5 and T6 were lower than those of T1, the differences were statistically significant (P＜0.05).The CVP, Paw and PetCO2 on T2, T3, T4, T5 and T6 in group S were higher than those in group V, the differences were statistically significant (P＜0.05).PaO2, pH value on T2, T3, T4, T5 and T6 in group S were lower than those in group V, and HR on the T3 was higher than that in group V, diastolic pressure on the T3, T4 was lower than that in group V, the differences were statistically significant (P＜0.05).SpO2 between the two groups was not significant difference (P＞0.05).The CO2 inflation pressure and hospitalization expenses in group S were higher than those in group V, the CO2 pneumothorax time and hospital stay in group S were longer than those in group V, the differences were statistically significant (P ＜0.05). Conclusion The application of carbon dioxide pneumothorax under general anesthesia with visual bronchial occlusion tube in video-assisted thoracoscopic radical esophageal cancer anesthesia was easy to operate, reduces the pressure of carbon dioxide insufflation, and control the hemodynamics of patients during the operation.This method had its unique advantages and safety, and was more suitale for it to promote to primary clinics.

Objective To investigate the curative effect of Bifidobacterium Triple Viable Bacteria Enteric-Coated Capsules in the treatment of children with acute leukemia chemotherapy-related diarrhea in order to guide clinical medication. Methods Fifty children with chemotherapy-related diarrhea associated with acute leukemia who were initially treated in the Children's Hematology Ward of the Hematology Diagnosis and Treatment Center of Tai'an Central Hospital Affiliated to Qingdao University from March 2017 to March 2021 were selected as the research subjects.According to the random number table method, they were divided into the experimental group and the control group, with 25 cases in each group.Both groups were given symptomatic and supportive treatment such as intravenous infusion,while the experimental group was added with oral administration of Bifidobacterium Triple Viable Enteric-Coated Capsules, 1 capsule each time, 2-3 times per day, for a total of 2 weeks of treatment.The time of diarrhea, the colony counts of Bifidobacterium, Lactobacillus acidophilus, and Escherichia coli in feces, plasma endotoxin and D-lactic acid content, and fecal calprotectin levels were compared between the two groups before treatment and after 2 weeks of treatment. Results The diarrhea time of the children in the experimental group was shorter than that in the control group, and the difference was statistically significant (P＜0.05).The colony counts of Bifidobacterium and Lactobacillus acidophilus in feces 2 weeks of treatment in the experimental group were more than those of the control group,the differences were statistically significant (P ＜0.05).The number of Escherichia coli colonies in the feces of the children in the experimental group was less than that in the control group after 2 weeks of treatment, the difference was statistically significant (P＜0.05).The children in the experimental group were treated for 2 weeks, the levels of plasma endotoxin, D-lactic acid, and fecal calprotectin were lower than those in the control group, and the differences were statistically significant (P＜0.05). Conclusion Bifidobacterium Triple Viable Enteric-Coated Capsules can shorten the time of chemotherapy-related diarrhea in children with acute leukemia, regulate the balance of intestinal flora, and improve the intestinal mucosal barrier function, which is worthy of clinical promotion.

 Clinical for repeated chest pain coronary angiography found in some patients with coronary artery and no clear stenosis, but its distal blood flow is delayed perfusion, except after thrombolysis, coronary plasty, coronary spasm,coronary expansion, cardiomyopathy, valve disease and a series of diseases, this phenomenon will be called coronary artery slow flow phenomenon.Coronary slow blood flow shows recurrent resting angina and may lead to serious cardiovascular events such as acute myocardial infarction, fatal arrhythmia and sudden cardiac death, and reduce the quality of life and life of patients.In recent years, due to the continuous development of coronary intervention technology, the phenomenon of coronary slow flow has gradually been paid attention to, but people still have little understanding of its pathogenesis and treatment, and a clear understanding of the treatment and prognosis of coronary slow flow phenomenon is lacking.This paper focuses on slow flow phenomenon of normal or near normal coronary artery, and summarize the possible pathogenesis, treatment, and the prognostic impact of the disease, and make a brief review of the research progress and treatment of slow blood flow phenomena in coronary arteries.

With the deepening of the aging of China's population, the number of disabled and semi-disabled elderly people has further increased, and most of the elderly suffer from various basic diseases and chronic diseases, and there is a great demand for medical and health services while providing for the elderly, so the model of combining medical and nursing care with old-age services has become a common direction for optimizing the traditional pension model.However, in the context of the rapid development of today's internet, the simple superposition of medical and pension services can not fully meet the needs of the elderly, "internet+" medical and nursing combination model has become a new choice, the model can use the advantages of big data, informatization, rational allocation of resources, further optimize the original medical and pension integration model, the formation of internet, medical and pension services tripartite synergy.This paper reviews the current situation of the development of the "internet+" medical and pension combination model at home and abroad, and expounds its advantages, summarizes the lack of interdepartmental coordination, the shortage of professional talents, the lack of audience recognition and the shortage of capital supply in the current "internet+" medical and pension combination model, and puts forward practical countermeasures for these problems.

In recent years, the incidence of neonatal brain injury remains high, and major research institutions are actively exploring neuroprotective agents.Magnesium Sulfate, as a non enzymatic antioxidant, has been proved to prevent cerebral palsy before delivery, and Magnesium Sulfate has been included in the neuroprotective guidelines for preterm infants in obstetrics.Magnesium Sulfate has the protective effects of anti-inflammatory, antioxidant and inhibition of apoptosis.Recently, the protective effect of Magnesium Sulfate on the nervous system has been widely concerned at home and abroad, and has become a hot spot in the study of the effect of Magnesium Sulfate.However, there are relatively few studies on Magnesium Sulfate in postpartum.At present, there is no unified conclusion whether postpartum use of Magnesium Sulfate has the same protective effect on nervous system.This paper mainly discusses the protective mechanism of Magnesium Sulfate on neonatal nervous system, reviews the mechanism of action of Magnesium Sulfate,the research of prenatal and postpartum Magnesium Sulfate, and the dosage of Magnesium Sulfate for perinatal newborns, in order to provide reference for clinical and scientific researchers in the research of nervous system protection of perinatal newborns.

Objective To establish a method for microbial limit test of Yikang Capsules. Methods The applicability of Yikang Capsules was studied according to general rules 1105,1106,1107 of the fourth part of the 2020 edition of Pharmacopoeia of the People's Republic of China.Firstly,the pan pour method(1∶10)was used to carry out the preliminary test.By calculating the recovery ratio of strains, the bacterial strains sensitive to Yikang Capsules were screened according to the standards.Then, the antibacterial activity of Yikang Capsules was removed by increasing the volume of diluent. Results When the total number of aerobic bacteria was 1∶20 and the total number of molds and yeasts was 1∶10,the recovery ratio of each test strain was in the range of 0.5-2.Control bacteria examination when conventional examination method was used, positive control group grew well, negative control group did not grow colony, all in line with the standard requirements. Conclusion The total number of aerobic bacteria by plate pouring method (1∶20), the total number of mold and yeast by plate pouring method (1∶10), the control bacteria inspection by conventional inspection method, the method is effective, feasible and reproducible, and can provide a reference for drug manufacturers or related drug inspection agencies to carry out microbial limit test of Yikang Capsules.

Objective To establish a reversed-phase high performance liquid chromatography method for the determination of rosmarinic acid in Modified Simiao Pills. Methods The separation was performed on an Apollo C18 column(4.6 mm×250 mm, 5 μm) with methanol-0.1% trifluoroacetic acid solution (42∶58) as mobile phase, at a flow rate of 1.0 ml/min.The detection wavelength was set at 330 nm, and the column temperature was 35℃. Results There was a good linear relationship between the peak area and the injection amount of rosmarinic acid in the range of 0.2016 to 1.8144 μg (r=0.9999).The average recovery was 96.14% with RSD of 0.55%.Three batches of Modified Simiao Pills were determined, with an average content of 468.2 mg/bag and RSD of 0.74%. Conclusion The established method for determination rosmarinic acid content in Modified Simiao Pills is simple and rapid, and can be used for the quality control of Modified Simiao Pills.

Objective To analyze the factors related to medication compliance of patients with epilepsy (EP) and mental disorder. Methods Sixty patients with EP and mental disorder who were admitted to the Third People's Hospital of Shangrao City from January 2019 to January 2022 were selected as the research subjects.The Morisky medication adherence scale (MMAS-8) was used to evaluate the patients' medication compliance, and they were were divided into group A (good compliance, n=38) and group B (poor compliance, n=22) according to compliance.The baseline data (gender, age, marital status, education level, occupation, social support, living pattern, living environment, family income,hospitalization times, etc.) were analyzed to investigate the reasons for poor medication compliance.Logistic regression analysis was conducted to screen the factors related to medication compliance of patients with EP and mental disorder.Results There were statistically significant differences between the two groups in living environment, monthly household income and hospitalization times (P＜0.05).Logistic regression analysis showed that monthly family income (β=1.021,OR=2.776, 95%CI=1.262-6.104) and living environment (β=0.964, OR=2.622, 95%CI=1.172-5.868) were influencing factors of patients' medication compliance (P＜0.05).Among the causes of poor medication compliance, the proportions of forgetting to take medicine for various reasons and thinking that taking medicine would be discriminated against were higher than 50%. Conclusion The main reasons for poor medication compliance of patients with EP and mental disorder include forgetting to take medication and thinking that taking medication will be discriminated against.The main influencing factors of patients' medication compliance include family income and living environment.

Objective To study the clinical effect of Phloroglucinol and Etimicin in the treatment of patients with spasmodic abdominal pain caused by acute gastroenteritis (AG). Methods A total of 104 patients with spasmodic abdominal pain caused by AG treated in the Department of Emergency, the First People's Hospital of Jiujiang City from October 1, 2021 to March 15, 2022 were selected as the research subjects, and they were divided into control group (n=52) and observation group (n=52) according to random number table method.The control group was injected with Racemic Anisodamine Hydrochloride and Levofloxacin Hydrochloride and Sodium Chloride, and the observation group was injected with Phloroglucinol and Etimicin.The levels of inflammatory cytokines (interleukin-6 [IL-6]and interleukin-8[IL-8]) between the two groups before and after 3 days of treatment were compared.The duration of symptoms (diarrhea, hyperthermia, nausea and vomiting, abdominal pain) of the two groups were compared.The clinical efficacy of the two groups was compared. Results After 3 days of treatment, the levels of IL-6 and IL-8 in the observation group were lower than those in the control group, the differences were statistically significant (P＜0.05).The duration of diarrhea,hyperthermia, nausea and vomiting, and abdominal pain in the observation group were shorter than those in the control group, the differences were statistically significant (P＜0.05).The total effective rate of the observation group was higher than that of the control group, the difference was statistically significant (P＜0.05). Conclusion Phloroglucinol and Etimicin in the treatment of patients with spasmodic abdominal pain caused by AG can effectively reduce the inflammatory response of patients, rapidly relieve clinical symptoms, and have good clinical effect.

Objective To explore the effect of increasing the pre-flushing cycle applied to severely poisoned patients with hemoperfusion (HP). Methods A total of 92 patients with severe HP poisoning admitted to the Second Affiliated Hospital of Hengyang Medical College of Nanhua University from April 2019 to June 2021 were selected as research objects.According to the random number table method, they were divided into control group and study group, with 46 cases in each group.The control group was given a static pre-filling method, and the study group was given a dynamic pre-filling method, compare the coagulation-related indicators and bleeding between the two groups. Results After perfusion, the activated partial thromboplastin time (APTT) and prothrombin time (PT) of the study group were shorter than those of the control group, and the fibrinogen (Fib) and platelet count (PLT) were higher than those of the control group, the differences were statistically significant (P＜0.05).The incidence of bleeding in the study group(2.17%) was lower than that in the control group (17.39%), and the difference was statistically significant (P＜0.05).Conclusion In patients with severe HP poisoning, increasing the pre-flushing cycle can reduce platelet loss after perfusion, thereby reducing the impact on coagulation function and the occurrence of bleeding at the puncture port.

Objective To explore the effect of cognitive intervention in patients with liver injury caused by anti-tuberculosis drugs. Methods A total of 87 patients with drug-induced liver injury caused by anti-tuberculosis treatment from April 2020 to April 2021 were selected as the research objects, they were divided into the control group (43 cases)and the observation group(44 cases)according to random number table method.The patients in the control group received routine nursing, and patients in the observation group received cognitive intervention.The anxiety, depression and drug-induced liver injury (DILI) related knowledge were compared between the two groups before and after the intervention.After 6 months of nursing, the negative rate of sputum smear and the absorption of lung lesions were compared in the two groups. Results There were no significant differences in the scores of self-rating anxiety scale (SAS) and self-rating depression scale (SDS) between the groups before the intervention (P＞0.05).After the intervention, the SAS and SDS scores of the observation group were lower than those of the control group, the differences were statistically significant (P＜0.05).Before the intervention, there were no significant differences in the DILI-related knowledge awareness scores between the two groups (P＞0.05).After the intervention, the DILI-related knowledge awareness scores in the observation group were higher than those in the control group, the differences were statistically significant (P＜0.05).After continuous intervention for 6 months, the absorption efficiency of X-ray lung lesions in the observation group(88.37%) was higher than that in the control group (72.09%), and the difference was statistically significant (P＜0.05).There was no significant difference in the sputum smear negative rate between the two groups (P＞0.05). Conclusion Cognitive intervention in patients with liver injury caused by antituberculosis drugs can improve short-term clinical efficacy, negative emotion and knowledge of antituberculosis drug therapy.

Objective To investigate the effect of Modified Xuefu Zhuyu Decoction combined with thoracoscopic TiNi memory alloy bone connector in the treatment of fractures of multiple ribs (FMR). Methods A total of 80 MRFs patients with thoracic trauma admitted to Meizhou Hospital of TCM from January 2020 to June 2021 were selected as subjects, and divided them into a control group and an observation group by random number table method, with 40 cases in each group.In the control group, patients were treated with internal fixation with TiNi memory alloy bone fittings under thoracoscope.On the basis of the control group, the observation group was additionally provided with the Modified Xuefu Zhuyu Decoction.The therapeutic efficacy, postoperative thoracic drainage tube indwelling time, pain disappearance time, swelling disappearance time, hospital stay, fracture healing time, and blood gas before and after treatment were compared between the two groups. Results The total effectiveness rate of the observation group was higher than that of the control group, and the difference was statistically significant (P ＜0.05).The postoperative thoracic drainage tube indwelling time, pain disappearance time, swelling disappearance time, hospital stay, and fracture healing time of the observation group were all shorter than those in the control group, with statistically significant differences(P＜0.05).After treatment, the arterial partial pressure of oxygen (PaO2), arterial oxygen saturation (SaO2) and oxygenation index (OI) in the observation group were all higher than those in the control group, the partial pressure of carbon dioxide in arterial blood (PaCO2) was lower than that in the control group, and the differences were statistically significant (P＜0.05). Conclusion Modified Xuefu Zhuyu Decoction combined with TiNi memory alloy bone connector treatment under thoracoscope can significantly improve the blood gas indexes in patients with FMR, improve the curative effect, and shorten the recovery time, which is worthy of clinical promotion.

Objective To study the clinical efficacy and safety of locking compression plate in the treatment of limb fractures. Methods A total of 200 patients with limb fractures admitted to Shuangqiao Hospital of Chaoyang District in Beijing from December 2018 to December 2020 were selected as the research objects, and divided into observation group and control group by computer randomly, with 100 patients in each group.The control group was treated with traditional compression plate internal fixation, and the observation group was treated with locking compression plate.The operative time, intraoperative blood loss and fracture healing time of the two groups were compared.The total effective rate of the two groups was compared.The incidence of complications was compared between the two groups.Results The operation time and fracture healing time of observation group were shorter than those in the control group,and the intraoperative blood loss was less than that in the control group, the differences were statistically significant(P＜0.05).The total effective rate of observation group was higher than that in the control group, and the difference was statistically significant (P＜0.05).The total incidence of complications in observation group was lower than that in the control group, the difference was statistically significant (P＜0.05). Conclusion Locking compression plate has high clinical efficacy and safety in the treatment of limb fractures.It can significantly improve the total effective rate, reduce complications, promote fracture healing and reduce bleeding.

Objective To investigate the related factors of postoperative mindfulness level in patients with thoracolumbar compression fracture (TCF). Methods A total of 96 TCF patients in the Department of Orthopedics of Longkou People's Hospital from October 2018 to October 2021 were selected as the research subjects.According to the score of mindful attention awareness scale (MAAS), there were 42 cases in the high level group (MAAS≥66 points) and 54 cases in the low level group (MAAS ＜66 points).The clinical data of the enrolled patients were collected and sorted through the hospital medical record system, and the influencing factors of postoperative mindfulness in TCF patients were analyzed. Results The postoperative MAAS score of TCF patients was (52.20±3.40) points.Univariate analysis showed that the degree of family care, pain level, and standardized rehabilitation training were related to the postoperative mindfulness level of TCF patients, and the difference was statistically significant (P＜0.05).Gender, education level, age, marital status, payment method of medical expenses, smoking history, and drinking history were not related to the postoperative mindfulness level of TCF patients, and the difference was not statistically significant (P＞0.05).Logistic regression analysis showed that the degree of family care was low/medium (β=1.291, OR=3.636, 95%CI: 1.523-8.682), severe pain (β=1.015, OR=2.759, 95%CI: 1.134-6.711), unstandardized rehabilitation training (β=1.079, OR=2.941, 95%CI: 1.102-7.849) were high-risk factor affecting the postoperative mindfulness level of TCF patients （P＜0.05）. Conclusion The postoperative mindfulness level of TCF patients is low, which is affected by the degree of family care, pain degree, and standardized rehabilitation training, and clinical attention should be paid to it.

Objective To investigate the new genes associated with the occurrence of hepatocellular carcinoma (HCC)by analyzing the transcriptome database downloaded from the cancer genome atlas (TCGA) database. Methods The mRNA expression profiles and associated clinical data, including 347 liver cancer tissues and 50 normal tissues, were obtained from TCGA database, and R software was used to explore the mRNA expression differences of Ephrin A1-5(EFNA1-5).The biomarker combined of multi EFNAs was established by logistic model.HCC group was divided into four group according to the Stage Ⅰ-Ⅳ, and each group was compared to the normal group.Receiver operating characteristic (ROC) curve was used to access the diagnostic value of one Ephrin As (EFNAs) and such biomarker combined of multi EFNAs in predicating the occurrence and progression of HCC. Results The mRNA expressions of EFNA1, EFNA3 and EFNA4 in HCC group were higher than those in the normal group, while the mRNA expressions of EFNA2 and EFNA5 were lower than those in the normal group, the differences were statistically significant (P＜0.01).The area under the curve (AUC) of the biomarker combined of EFNA3 and EFNA4 was 0.923, its sensitivity was 0.879 and specificity was 0.880.Furthermore, the AUC of the biomarker combined of EFNA3 and EFNA4 was 0.908, 0.946, 0.938 respectively in predication of HCC progression such as Stage Ⅰ, Ⅱ, Ⅲ, which was higher than that of single EFNAs(P＜0.01). Conclusion EFNAs maybe a valuable biomarker in predicating the occurrence of HCC, especially the synergistical predication biomarker combined of EFNA3 and EFNA4.

Objective To investigate the effect of Kanglaite combined with stereotactic radiotherapy in improving the radiotherapy effect of patients with advanced non-small cell lung cancer. Methods A total of 60 patients with advanced non-small cell lung cancer treated in Shangrao Municipal Hospital from January 2017 to December 2021 were selected as the research objects.They were divided into control group (30 cases) and study group (30 cases) according to random number table method.The control group was treated with stereotactic radiotherapy alone, and the study group was treated with stereotactic radiotherapy combined with Kanglaite.The total treatment efficiency and quality of life of the two groups were compared. Results After two cycles of treatment, the total treatment efficiency of patients in the study group was higher than that in the control group, the difference was statistically significant (P＜0.05).The physical function score, role function score and emotional function score in the quality of life questionare-C30 (QLQ-C30) score were higher than those in the control group, the differences were statistically significant (P＜0.05). Conclusion Kanglaite combined with stereotactic radiotherapy can effectively improve the efficiency of radiotherapy for patients with advanced non-small cell lung cancer.It is an effective therapy for the treatment of advanced non-small cell lung cancer.It is suitable for large-scale implementation and promotion in clinic.

Objective To explore the effect of different disinfection methods on preventing fat liquefaction of cesarean section in obese women during pregnancy. Methods A total of 90 obese pregnant women scheduled for lower uterine cesarean section in Huizhou Third People's Hospital from September 2020 to July 2021 were divided into group A, B and C by random number table method, with 30 cases in each group.Group A, B and C were routinely intervened, and they were disinfected before and during operation with 2% Chlorhexidine Gluconate, Povidone Iodine and 0.5%Iodophor respectively.The incidences of incision fat liquefaction and incision infection, postoperative rehabilitation and hospitalization expenses were compared among the three groups. Results The incidence of incision fat liquefaction and incision infection in group A were lower than those in group C,with statistically significant differences(P＜0.01),and there was no statistically significant difference in the above indicators of group B compared with group A and group C (P＞0.05).The anal exhaust time, indwelling catheterization time, time to get out of bed for the first time and time to eat for the first time in group A and group B were shorter than those in group C, and the above times in group A were shorter than those in group B, and the hospitalization time in group A was shorter than that in group C, then the hospitalization expenses of group A and group B were less than those in group C, and the hospitalization expenses of group A were less than those in group B, with statistically significant differences (P＜0.05). Conclusion Compared with Povidone Iodine and Iodophor, Chlorhexidine Gluconate disinfection for cesarean section of pregnant obese pregnant women can reduce the occurrence of incision fat liquefaction and infection, so as to achieve the purpose of promote rehabilitation and reduce hospitalization expenses.

Objective To discuss the application effects of modified Minnan Jingfang Sishen Decoction in remission stage of asthma children. Methods A total of 106 remission stage of asthma children from January 2020 to June 2021 in Department of Pediatrics, the Affiliated Dongnan Hospital of Xiamen University were selected as research subjects.They were divided into the control group and the observation group by random number table method, with 53 cases in each group.The control group took western medicine, and the observation group took western medicine and modified Minnan Jingfang Sishen Decoction.Treatment effects and safety were probed. Results The total effective rate in the observation group was higher than that in the control group, with statistically significant difference (P＜0.05).Exhaled nitric oxide (FeNO), emergency frequency and asthma attack frequency in the observation group were lower than those in the control group, with statistically significant difference (P＜0.05).Traditianal Chinese medicine symptom scores in the observation group were lower than those in the control group, with statistically significant difference (P＜0.05).After treatment, lung function indicators in the observation group were higher than those in the control group, with statistically significant difference (P＜0.05).CD4+ and CD4+/CD8+ levels in the observation group were higher than those in the control group, and CD8+level was lower than that in the control group,with statistically significant difference (P＜0.05).The total incidences of adverse reactions between two groups showed no statistically significant difference (P＞0.05).Conclusion The modified Minnan Jingfang Sishen Decoction can reduce the clinical symptoms, and improve the lung function, immune function and treatment safety for remission stage of asthma children.

Objective To evaluate the effect of hysteroplasty on reducing the formation of lower uterine diverticulum after cesarean section with scarred uterus. Methods From January to June 2020, a total of 60 pregnant women with scarred uterus who were admitted to the obstetrics department of Sanshui District Maternal and Child Health Hospital of Foshan City in Guangdong Province were selected as the research objects, and they were divided into the control group (30 cases) and the observation group (30 cases) according to the patients' wishes.The control group underwent a second cesarean section, and the observation group underwent a second cesarean section combined with hysteroplasty.The two groups of women were followed up by clinical and vaginal color Doppler ultrasound, and the incidence of lower uterine segment diverticulum, severity, and quality of life before and after treatment of the two groups were compared and analyzed. Results The incidence of lower uterine segment diverticulum in the observation group was lower than that in the control group, and the above differences were statistically significant (P＜0.05).There was no difference in the quality of life scores between the two groups before surgery, and the difference was not statistically significant (P＞0.05).And after surgery, the quality of life scores of the two groups were higher than those before surgery, and the observation group was higher than the control group, with statistically significant differences (P＜0.05). Conclusion The application of hysteroplasty can significantly reduce the formation of diverticulum in the lower uterine segment of patients with scarred uterus after cesarean section, and has a significant effect in improving the severity of uterine diverticulum.

Objective To investigate the application effect of using Caffeine Citrate at different times in the prevention and treatment of apnea in premature infants. Methods A total of 100 premature infants admitted to Jiangmen Maternal and Child Health Hospital from April 2020 to March 2021 were selected as research subjects, and divided into the observation group (50 cases) and the control group (50 cases) by random number table method.Premature infants in the control group were administered after respiratory depression, and premature infants in the observation group were administered preventively within 24 hours after birth.The incidence of apnea, oxygen use time, non-invasive respiratory ventilation time and the incidence of complications were compared between the two groups. Results The incidence of apnea in the observation group was lower than that in the control group, and the difference was statistically significant(P＜0.05).The duration of oxygen use and non-invasive respiratory ventilation in the observation group were shorter than those in the control group, and the differences were statistically significant (P＜0.05).The incidence of retinopathy of prematurity (ROP), intracranial hemorrhage (IVH) and bronchopulmonary dysplasia (BPD) in the observation group was lower than that in the control group, and the difference was statistically significant (P＜0.05). Conclusion Early use of Caffeine Citrate in premature infants has a better effect on the prevention of apnea, can effectively shorten the time of oxygen use and non-invasive respiratory ventilation, reduce the occurrence of retinopathy, bronchopulmonary dysplasia and other complications.

Objective To investigate the efficacy of Oryzanol combined with Complex Packing Estradiol Tablets/Estradiol and Dydrogesterone Tablets in the treatment of perimenopausal syndrome and its effect on endometrial thickness and neurotransmitters. Methods A total of 92 case of perimenopausal syndrome patients in Putian First Hospital during March 2019 to July 2021 were selected as studying object.They were divided into the control group and the intervention group by random number table method, with 46 cases in each group.The control group was given Oryzanol treatment, and the intervention group was given Oryzanol combined with Complex Packing Estradiol Tablets/Estradiol and Dydrogesterone Tablets treatment.The curative effect, sex hormone levels, endometrial thickness, and neurotransmitter levels before treatment and one month after treatment were compared between the two groups, and the related adverse drug reactions were compared between the two groups. Results The total effective rate of the intervention group was higher than that of the control group, and the difference was statistically significant (P＜0.05).There was no significant difference in the levels of follicle-stimulating hormone (FSH), luteinizing hormone (LH) and estradiol (E2) between the two groups before treatment (P＞0.05).The level of E2 was higher than that of the two groups before treatment, and the difference was statistically significant (P＜0.05).The FSH and LH levels of the intervention group on 28 days of treatment were lower than those of the control group, and E2 level was higher than that of the control group, and the difference was statistically significant (P＜0.05).There was no significant difference in endometrial thickness, serotonin (5-HT) and norepinephrine (NE) levels between the two groups before treatment (P＞0.05).The thickness and 5-HT levels of the two groups were higher than those before treatment, and the NE level was lower than that of the two groups before treatment, and the difference was statistically significant (P＜0.05).The level of NE was higher than that of the control group on the 28th day of treatment, and the level of NE was lower than the level of the control group on the 28th day of treatment, and the difference was statistically significant (P＜0.05).There was no significant difference in the incidence of adverse drug reactions between the two groups (P＞0.05). Conclusion Oryzanol combined with Complex Packing Estradiol Tablets/Estradiol and Dydrogesterone Tablets in the treatment of perimenopausal syndrome can significantly improve the endometrial thickness, sex hormone and neurotransmitter levels of patients, and has more significant clinical efficacy without increasing the risk of adverse drug reactions.

Objective To explore the value of 0.01% Aropine Eye Drops combined with frame glasses in controlling adolescent myopia. Methods A total of 118 adolescent myopia patients admitted to the First Affiliated Hospital of Jiangxi Medical College from March 2019 to March 2021 were selected retrospectively as research objects.According to the different treatment methods, they were divided into experimental group and control group, with 59 cases in each group.The control group was treated with frame glasses, and the experimental group was treated with 0.01% Atropine Eye Drops on the basis of control group.The intraocular pressure, tear film rupture time, axial length, diopter and adverse reactions (corneal epithelial spot dyeing, conjunctivitis, photophobia and corneal infection) were compared between the two groups.Patients with ocular adverse drug reactions after myopia treatment with 0.01% Atropine Eye Drops in the experimental group were included in the occurrence group, and patients without adverse drug reactions were included in the non occurrence group.The basic data of the two groups were compared, receiver operating characteristic (ROC) curve was used to analyze the value of 0.01% Atropine administration time in predicting ocular adverse drug reactions after myopia treatment, and the difference information between the two groups was incorporated into logistic regression analysis model, and the quantitative assignment was made to clarify the risk factors of ocular adverse drug reactions after myopia treatment with 0.01% Atropine Eye Drops. Results There were no significant differences in intraocular pressure, tear film rupture time,axial length and diopter between the two groups before and after treatment (P＞0.05).There was no significant difference in the incidence of corneal epithelial staining, conjunctivitis, photophobia and corneal infection between the two groups(P＞0.05).In the experimental group, 8 patients with eye drug adverse reactions after myopia treatment with 0.01% Atropine Eye Drops were included in the occurrence group, and 51 patients without occurrence were included in the nonoccurrence group.Univariate analysis showed that there were no significant differences in age, sex and family history of myopia between the two groups (P＞0.05).0.01% Atropine Eye Drops have statistically significant relationship with regular visual inspection, balanced nutrition, good eye habits and administration time (P＜0.05).Taking the occurrence of ocular adverse drug reactions after myopia treatment with 0.01% Atropine Eye Drops as dependent variable and statistically significant variables in univariate analysis as independent variables, logistic regression model was used for multivariate analysis.The results showed that no regular visual examination (β=0.436, OR=1.547, 95%CI=1.186-2.018), unbalanced nutrition (β=0.555, OR=1.742, 95%CI=1.279-2.373), poor eye habit (β=0.393, OR=1.481, 95%CI=1.037-2.115), long administration time (β=1.432, OR=1.540, 95%CI=1.016-2.204) were the risk factors of ocular adverse drug reactions after myopia treatment with 0.01% Atropine Eye Drops.ROC analysis confirmed that the AUC predicted by regular visual inspection, nutritional balance, eye habits and administration time were 0.830, 0.782, 0.862 and 0.911 respectively (P＜0.05). Conclusion There are many influencing factors of the occurrence of ocular adverse drug reactions after myopia treatment with 0.01% Atropine Eye Drops.We should regularly check the eyesight, keep good eye habits and strictly control the medication time to achieve better control of myopia.

Objective To investigate the application effect of new desensitization reagent fixation device in patients with dentine hypersensitivity after radiotherapy for locally advanced nasopharyngeal carcinoma. Methods A total of 40 patients with dentin hypersensitivity after locally advanced nasopharyngeal carcinoma radiotherapy (with 167 affected teeth) admitted to Affiliated Cancer Hospital & Institute of Guangzhou Medical University from June 2019 to June 2021 were selected as research objects, they were divided into research group and control group according to computer randomization method.The patients in the control group were treated with Gluma desensitization agent in the oral room and assisted with family routine treatment of oral desensitization paste.The patients in the research group were treated with Gluma desensitization agent in the oral clinic with a new desensitization reagent fixation device combined with the oral desensitization paste.Dental sensitivity of the two groups before and after 4 weeks and the dental essence desensitization treatment efficiency were compared by visual analogue scale (VAS). Results There was no significant difference in VAS value of dental sensitivity between the two groups (P＞0.05).The VAS value of dental sensitivity in the research group after 4 weeks was higher than that of the control group, the difference was statistically significant (P＜0.05).The dental essence desensitization treatment efficiency of research group after 4 weeks was higher than that of the control group, the difference was statistically significant (P＜0.05). Conclusion For patients with dentin hypersensitivity after locally advanced nasopharyngeal carcinoma radiotherapy, new desensitization reagent fixation device can effectively improve the desensitization treatment effect and obtain good early effect, which has clinical application value.

Objective To investigate the effect of systemic medication combined with retroauricular injection of Methylprednisolone Sodium Succinate in the treatment of full-frequency descending sudden hearing loss. Methods The clinical data of 106 patients with full-frequency descending sudden hearing loss admitted to Huai'an First People's Hospital Branch from January 2020 to September 2021 were retrospectively analyzed, they were divided into the combined group (55 cases) and conventional group (51 cases) according to different treatment methods.The combined group was treated with systemic medication combined with Methylprednisolone Sodium Succinate for retroauricular injection, and the conventional group was treated with systemic hormone alone.The therapeutic effects and the results of the speech recognition rate test, the pure tone audiometry test results and the incidence of adverse reactions during medication before and after treatment between the two groups were compared. Results There was no significant difference in the total effective rate between the two groups (P＞0.05).After treatment, the speech recognition rate in the combined group was higher than that in the conventional group, and the pure tone hearing threshold was lower than that in the conventional group, and the differences were statistically significant (P＜0.05).There was no significant difference in the incidence of adverse reactions between the two groups (P=0.931). Conclusion Compared with conventional systemic medication,systemic medication combined with retroauricular injection of Methylprednisolone Sodium Succinate can improve the speech recognition rate and pure tone hearing threshold of full-frequency descending sudden hearing loss patients,which is safe and reliable.

Objective To explore the application effect of Esketamine and Fentanyl on pain rating index and sleep quality in patients with phantom limb pain after traumatic amputation. Methods A total of 84 patients with phantom limb pain after traumatic amputation treated in the hospital between June 2019 and August 2020 were selected as the research subjects, and they were divided into the control group and the observation group by drawing lots, with 42 cases in each group.The control group was treated with Fentanyl, while the observation group was given Fentanyl+Esketamine.The pain rating index and sleep quality, etc.were compared between the two groups after medication. Results After treatment, the scores of pain rating index (PRI), visual analogue scale (VAS) and present pain intensity (PPI) in the observation group were lower than those in the control group, and the differences were statistically significant (P＜0.05).After treatment, the scores of sleep time, sleep efficiency, sleep disorder, hypnotic drugs and daytime function were lower in the observation group than those in the control group, and the differences were statistically significant (P＜0.05). Conclusion Esketamine combined with Fentanyl can effectively relieve the pain and enhance the sleep quality in patients with phantom limb pain after traumatic amputation.

Objective To explore the application effect of transnasal humidified rapid-insufflation ventilatory exchange(THRIVE) on patients with obesity undergoing painless gastroscopy. Methods A total of 80 obese patients requiring painless gastroscopy in Zhangzhou Zhengxing Hospital between January 2019 and January 2021 were selected as the research subjects, and they were divided into rapid-insufflation group (n=40) and traditional group (n=40) by drawing lots.THRIVE was used during intravenous anesthesia in rapid-insufflation group and traditional nasal cannula oxygen inhalation was adopted in traditional group.The gastroscopy status, vital signs, adverse events and occurrence of adverse reactions were compared between the two groups. Results There were no statistical differences in the recovery time of anesthesia and the dosage of Propofol between the two groups (P＞0.05), and the gastroscopy time in rapid-insufflation group was shorter than that in traditional group, and the difference was statistically significant (P＜0.05).There were no statistical differences in mean arterial pressure (MAP) and heart rate (HR) before anesthesia, at the beginning of examination and during 5 min of examination between the two groups (P＞0.05).The MAP and HR at the end of gastroscopy in rapid-insufflation group were lower than those in traditional group, and were lower than those at the beginning of examination, and the differences were statistically significant (P＜0.05).There was no statistical significance in blood oxygen saturation (SpO2) between the two groups before anesthesia (P＞0.05), and the SpO2 values in rapid-insufflation group at the beginning of gastroscopy, during 5 min of gastroscopy and at the end of gastroscopy were higher than those in traditional group, and the differences were statistically significant (P＜0.05).There was no significant difference in SpO2 at the beginning of examination compared with that during 5 min of examination in rapid-insufflation group (P＞0.05), but the difference was statistically significant at any two time points in rapid-insufflation group (P＜0.05).The total incidence rate of adverse events in rapid-insufflation group was lower than that in traditional group,and the difference was statistically significant (P＜0.05).There was no statistical significant differences in the total incidence rate of adverse reactions between the two groups (P＞0.05). Conclusion The application of THRIVE during intravenous anesthesia can shorten the exa mination time, maintain the stability of vital signs and reduce the occurrence of adverse events of patients with obesity undergoing painless gastroscopy, with safety.

Objective To investigate the effect of Dexmedetomidine combined with Ropivacaine intermuscular sulcus nerve block on the analgesic effect and bispectral index (BIS) value of patients. Methods A total of 83 patients undergoing upper arm surgery admitted to Huairou District Hospital of Traditional Chinese Medicine in Beijing from April 2019 to March 2021 were selected as the research objects, and they were divided into observation group (41 cases) and control group (42 cases) by random number table method.Control group was given Ropivacaine combined with placebo block, and observation group was given Ropivacaine combined with Dexmedetomidine block.The onset time of analgesia, duration of analgesia, onset time of exercise block and recovery time of exercise were compared between the two groups, and the changes of BIS values at different intraoperative time were compared between the two groups. Results There was no significant difference in the onset time of analgesia between the two groups (P＞0.05).The duration of analgesia in observation group was longer than that in control group, and the difference was statistically significant (P＜0.05).There was no significant difference in the effective time of movement block between the two groups (P＞0.05).The exercise recovery time of observation group was longer than that of control group, and the difference was statistically significant (P＜0.05).BIS values of T1-T5 in observation group were lower than those in control group, the differences were statistically significant (P＜0.05).In the observation group, BIS value at T1 was lower than T0, BIS value at T2 was lower than T1, and BIS value at T4 was higher than T3, the differences were statistically significant (P＜0.05).In the control group, BIS value at T2 was lower than T1, BIS value at T3 was lower than T2, BIS value at T4 was higher than T3, and BIS value at T5 was higher than T4, the differences were statistically significant (P＜0.05). Conclusion Dexmedetomidine combined with Ropivacaine intermuscular sulcus nerve block can prolong the patient's exercise recovery time and the duration of analgesia, and improve the patient's anesthesia effect.

Objective To investigate the efficacy and safety of Tenofovir Alafenamide Fumarate combined with Pegylated Interferon α-2b in the treatment of patients with chronic hepatitis B. Methods A total of 82 patients with chronic hepatitis B who were treated in Sihong County People's Hospital from May 2018 to May 2020 were selected as the study subjects and divided into study group (n=41) and control group (n=41) according to random number table method.The control group was treated with Tenofovir Alafenamide Fumarate, and the research group was treated with Pegylated Interferon α-2b on the basis of the control group.The clinical efficacy and medication safety of the two groups were compared. Results After 12 months of treatment, the hepatitis B virus DNA (HBV-DNA) in the study group was lower than that in the control group, and the difference was statistically significant (P＜0.05).The normalization rate of alanine aminotransferase (ALT) in the study group was higher than that in the control group after 6 and 12 months of treatment,and the differences were statistically significant (P＜0.05).The serum conversion rate of hepatitis B e antigen (HBeAg)in the study group was higher than that in the control group after 6 months of treatment, and the serum conversion rate of HBeAg and HBeAg in the study group were higher than that in the control group after 12 months of treatment, and the differences were statistically significant (P＜0.05).There was no significant difference in the total incidence of adverse reactions between two groups (P＞0.05). Conclusion Tenofovir Alafenamide Fumarate combined with Pegylated Interferon α-2b in the treatment of chronic hepatitis B patients has good clinical efficacy, and the incidence of adverse reactions in patients is less, and the drug safety is high.

Objective To investigate the occurrence and risk factors of upper gastrointestinal bleeding caused by dual antiplatelet therapy. Methods The clinical data of 212 patients with coronary heart disease who received dual antiplatelet therapy in the First People's Hospital of Nankang District, Ganzhou City from September 2018 to August 2020 were retrospectively analyzed.All patients received dual antiplatelet therapy.After 1 year of treatment, the incidence of upper gastrointestinal bleeding was analyzed.Patients were divided into occurrence group and non-occurrence group according to whether upper gastrointestinal bleeding occurred or not.The clinical data of the two groups including gender, age, complicated underlying diseases, history of peptic ulcer, history of alcohol consumption, application of gastric mucosal protective agent, proton pump inhibitor and serum creatinine (Scr) level were analyzed, and the risk factors for upper gastrointestinal bleeding were analyzed. Results 212 patients with coronary heart disease were treated with dual antiplatelet therapy, and 25 patients developed upper gastrointestinal bleeding during one-year follow-up,with an incidence rate of 11.79% (25/212).The proportion of patients with peptic ulcer related history, no use of proton pump inhibitors and Scr level ＞113 μmol/L in the occurrence group were higher than those in the non-occurrence group, and the differences were statistically significant (P＜0.05).Multivariate logistic regression analysis showed that a history of peptic ulcer, no use of proton pump inhibitors and Scr level ＞113 μmol/L were independent risk factors for upper gastrointestinal bleeding induced by dual antiplatelet therapy (P＜0.05). Conclusion Dual antiplatelet therapy may lead to upper gastrointestinal bleeding, and the related risk factors should be paid more attention to in clinic.

Objective To explore the clinical effect of Zhizhu Liujunzi Decotion in the treatment of lung cancer patients with Qi -deficiency syndrome during chemotherapy, and the influence on tongue coating thickness and the gastrointestinal reaction. Methods A total of 90 patients with lung cancer and Qi-deficiency syndrome treated with chemothrapy in Dazhou Hospital of Integrated Traditional Chinese and Western Medicine from October 2019 to October 2020 were selected as the reseach objects, and they were divided into the treatment group (45 cases) and the control group (45 cases) according to random number table method.The control group was treated with normally antiemetic and stomach protector, and the treatment group was treated with Zhizhu Liujunzi Decotion on the basis of the treatment of the control group.The tongue coating thickness scores were compared between the two groups before and after treatment.The occurrence of gastrointestinal reactions was compared between the two groups.The quality of life of two groups before and after treatment was evaluated by cancer treatment function evaluation system-lung cancer (FACT-L).Results The scores of tongue colding thickness after treatment were higher than those before treatment both in two groups, with stastistically significant differences (P＜0.05).The scores of tongue colding thickness after treatment in the treatment group was lower than that in the control group, and the difference was stastistically significant (P＜0.05).The incidence rates of dysorexia, nausea, vomiting, diarrhea and astriction in treatment group were lower than those in control group, with stastistically significant differences (P ＜0.05).The score of the FACT-L after treatment in the treatment group was higher than that in the control group, with stastistically significant difference (P＜0.05). Conclusion Zhizhu Liujunzi Decotion may influence the tihckness of tongue coating of lung cancer patients with Qi-deficiency syndrome treated with chemotherapy, which may reduce the occurrence of gastrointestinal reactions in these patients, and further study is worthy.

Objective To analyze the clinical efficacy of holographic meridian scraping therapy combined with Zishen Pinggan therapy in the treatment of climacteric hypertension. Methods A total of 60 patients with menopause hypertension with yin deficiency and yang hyperactivity treated in Yancheng Hospital of Traditional Chinese Medicine from December 2019 to June 2021 were selected as the research objects, and they were divided into control group and observation group according to random number table method, with 30 cases in each group.Control group was given Irbesartan Tablet oral antihypertensive treatment, observation group was given holographic meridian scraping therapy combined with Zishen Pinggan treatment.The clinical efficacy, traditional Chinese medicine (TCM) syndrome score and hormone levels were compared between the two groups before treatment and 1 month after treatment. Results The curative effect of observation group was better than that of control group, and the difference was statistically significant (P＜0.05).There was no significant difference in TCM syndrome score between the two groups before treatment (P＞0.05).The TCM syndrome score of the two group after treatment were lower than those before treatment, the differences were statistically significant (P＜0.05).The TCM syndrome score of the observation group was lower than that of the control group after treatment, the difference was statistically significant (P＜0.05).There were no significant differences in serum levels of estradiol (E2), androgen (T) and follicle stimulating hormone (FSH) between the two groups before treatment (P＞0.05).The serum E2 level of the two group after treatment were higher than those before treatment, while T and FSH levels were lower than those before treatment, the differences were statistically significant(P＜0.05).After treatment, serum E2 level in observation group was higher than that of control group, while T and FSH levels were lower than those of control group, the differences were statistically significant (P＜0.05). Conclusion The holographic meridian scraping therapy combined with Zishen Pinggan therapy has a definite clinical effect on climacteric hypertension, which can relieve the symptoms of menopause and improve the level of hypertension and estrogen levels in patients with climacteric hypertension.It is worthy of broad application.

Objective To analyze the influencing factors of false-negative in thinprep cytolog test (TCT) of patients with cervical intraepithelial neoplasia (CIN). Methods A retrospective analysis was performed on cytological test results of 96 patients with CIN who underwent TCT between April 2019 and May 2021 in Pathological Diagnosis Center, Hu'nan Cancer Hospital.According to the results, negative, i.e., no intraepithelial lesion or malignant lesion (NILM) was considered as cytological false negative, and cytological false negative patients were selected as observation group and cytological abnormal patients as control group.At the same time, the age, lesion sites and other relevant clinical data of patients in the two groups were counted.The data with statistical differences were analyzed by univariate logistic multifactor analysis, and targeted and effective protective measures were proposed according to the relevant factors. Results TCT showed that there were 12 (8.00%) false-negative cases among the 96 patients with CIN, with a false-negative rate of 12.50%.There were statistically significant differences between the observation group and the control group in the proportion of patients ≥30 years old, cervical single-site lesion, distance between the lesion and cervical canal ≥1 cm, cell concentration＜40%, severe cervical inflammation, missed diagnosis by cytology doctor, glandular cells or metaplastic cells, and bleeding smears (P＜0.05).There were no statistically significant differences between the two groups in the severity of the disease, severe cervical erosion, irregular cervix and cervical foreign bodies (P＞0.05).Multivariate logistic analysis results showed that age≤30 (β=0.074, OR=1.077, 95%CI=1.023-1.133), distance between the lesion and cervical canal ≥1 cm (β=0.289, OR=1.335, 95%CI=1.106-1.611), cell concentration ＜40% (β=0.342, OR=1.383, 95%CI=1.067-1.791), missed diagnosis by cytology doctor (β=0.364, OR=1.439, 95%CI=1.092-1.897), no glandular cells or metaplastic cells (β=0.354, OR=1.412, 95%CI=1.112-1.793), and bleeding smear (β=0.374, OR=1.454,95%CI=1.107-1.909) were independent risk factors for false negative diagnostic results of TCT (P＜0.05). Conclusion The age and distance between lesion and cervical canal will lead to false-negative in TCT.Analysis of related factors and conducting corresponding preventive measures are beneficial to reduce false-negative in cytology.

Objective To investigate the correlation between serum citrulline and neonatal necrotizing enterocolitis(NEC). Methods A total of 80 NEC children admitted to Panjin Liaoyou Baoshihau Hospital from April 2019 to March 2021 were selected as the study group.According to the modified BELL staging criteria, they were divided into group A(NEC stage Ⅰ, 26 cases), group B (NEC stage Ⅱ, 32 cases) and group C (NEC stage Ⅲ, 22 cases).Fifty healthy neonates who received physical examination at the same period were selected as the control group (CG).The serum levels of citrulline, procalcitonin (PCT) and C-reactive protein (CRP) were compared among all groups, and the correlation between serum citrulline level and PCT and CRP levels was analyzed.The receiver operating characteristic (ROC)curve of serum citrulline for neonatal NEC was drawn and the area under the curve(AUC)was calculated.Finally,80 children were divided into cured group (68 cases) and poor prognosis group (12 cases) according to clinical outcome, and the correlation between serum citrulline level and prognosis of NEC neonates was preliminarily analyzed. Results The serum levels of PCT and CRP in groups A, B and C were higher than those in CG group, and the levels of citrulline were lower than those in CG group, the differences were statistically significant (P＜0.05).The serum levels of PCT and CRP in group A were lower than those in groups B and C, and the levels of citrulline were higher than those in groups B and C, the differences were statistically significant (P＜0.05).The serum levels of PCT and CRP in group B were lower than those in group C, and the level of citrulline was higher than that in group C, the differences were statistically significant (P＜0.05).Serum citrulline level was negatively correlated with PCT and CRP levels in NEC children(r=-0.7209, -0.9511, P＜0.05).The serum citrulline level in the cured group was higher than that in the poor prognosis group, and the serum PCT and CRP levels were lower than those in the poor prognosis group, the differences were statistically significant (P＜0.05).Using 21.67 μmol/L as cut-off point, the diagnostic ROC curve of serum citline for NEC children was plotted, and the AUC was calculated to be 0.905 (95%CI=0.813-0.997, P＜0.001). Conclusion Serum citrulline levels are significantly different in children with NEC with different disease course and different prognosis, which can be considered for the diagnosis and prognosis analysis of NEC.

Objective To explore the effect of evidence-based nursing in the treatment of short stature in children with Recombinant Human Growth Hormone (rhGH). Methods A total of 60 children with dwarfism admitted to Department of Pediatrics, Jingdezhen Maternal and Child Health Care Hospital from March 2019 to March 2021 were divided into two groups according to random number table method, with 30 children in each group.Routine nursing was carried out in the control group and evidence-based nursing was carried out in the observation group.Both groups were followed up for 1 year.Insulin levels, adverse reactions and nursing satisfaction were compared between the two groups. Results The levels of insulin growth factor 1 (IGF-1) and insulin growth factor binding protein 3 (IGFBP-3) in observation group after nursing were higher than those in the control group, the differences were statistically significant (P＜0.05).The total incidence of adverse reactions in the observation group was lower than that in the control group, and nursing satisfaction in the observation group was higher than that in the control group, with statistical significances (P＜0.05).Conclusion Evidence-based nursing has good application effect in rhGH treatment of short stature children, which is beneficial to improve insulin level, promote height growth, reduce complications and improve nursing satisfaction.

Objective To explore the influence of Baduanjin exercise rehabilitation nursing on the rehabilitation of patients with chronic heart failure (CHF). Methods A total of 89 patients with CHF treated in the First Affiliated Hospital of Nanchang University between January 2020 and May 2021 were selected as the research subjects for retrospective analysis.According to the different nursing methods, the patients were divided into control group (n=44) and observation group (n=45).The control group adopted routine nursing, and the observation group was given routine nursing combined with Baduanjin exercise rehabilitation nursing.The 6 min walking test (6MWT), left ventricular ejection fraction (LVEF) and Minnesota living with heart failure questionnaire (MLHFQ) were compared between the two groups.Results After nursing, the 6MWT of patients of the two groups were longer than those before nursing, with statistically significant differences (P＜0.05).After nursing, the 6MWT of the observation group was longer than that of the control group, and the difference was statistically significant (P＜0.05).There were no significant differences in LVEF levels between the two groups before and after nursing (P＞0.05).The scores of MLHFQ in the two groups after nursing were lower than those before nursing, the differences were statistically significant (P＜0.05).The MLHFQ score of observation group was lower than that of control group after nursing, the difference was statistically significant (P＜0.05). Conclusion The application of Baduanjin in CHF patients has a good effect on rehabilitation training, which can effectively improve the patients' motor ability, and thus improve the quality of life.

Objective To explore the application effect of group intervention in patients with gastrointestinal cancer after surgery. Methods Seventy-six patients with gastrointestinal cancer after surgery in the Jiangxi Cancer Hospital from May 2020 to April 2021 were selected as the study subjects by convenience sampling method.According to the ward,the patients were divided into control group (38 cases) and experimental group (38 cases).One patient in the control group was absent from the training course, one patient in the experimental group was absent from the training course,and one patient was transferred to the hospital resulting in shedding.Finally, there were 37 patients in the control group and 36 patients in the experimental group.The control group was given traditional health guidance mode, and the experimental group was given group intervention mode for health guidance.The scores of readinessfor hospital discharge scale (RHDS) and Barthel scale were compared between the two groups 1 day after surgery (T0), 1 week after surgery (T1), and before discharge (T2). Results There was no significant difference in the RHDS score between the two groups at T0 (P＞0.05).The RHDS score of the experimental group was higher than that of the control group at T1 and T2, and the difference was statistically significant (P＜0.05).There was no significant difference in the Barthel scale scores between the two groups at T0 (P＞0.05).The Barthel scale scores in the experimental group were higher than those in the control group at T1 and T2, and the differences were statistically significant (P＜0.05). Conclusion Compared with the traditional health education model, group intervention can more effectively improve the discharge readiness and self-care ability of patients after gastrointestinal cancer surgery.

Objective To explore the effect of behavioral impulse intervention nursing on impulsive behaviors and quality of life in patients with bipolar disorder treated by brain therapeutic apparatus. Methods A total of 76 patients with bipolar disorder who were admitted to Shangrao Third People's Hospital for treatment from January 2019 and December 2019 were selected as subjects, and they were divided into observation group (n=38) and control group (n=38)by the random number table method.Both groups adopted A620 brain therapeutic apparatus, and the control group was given conventional nursing intervention while the observation group was treated with behavioral impulse intervention nursing.The modified overt aggression scale (MOAS) was used to evaluate and compare the impulsive behavior of the two groups before and after intervention.The generic quality of life inventory-74 was used to evaluate and compare the quality of life of the two groups before and after intervention. Results There were no significant differences in MOAS scores between the two groups before intervention (P＞0.05).MOAS scores of the two groups after intervention were lower than those before intervention, the differences were statistically significant (P＜0.05).After intervention, MOAS score of observation group was lower than that in the control group, the difference was statistically significant (P＜0.05).There were no significant differences in the scores of quality of life between the two groups before intervention (P＞0.05).The scores of social function, psychological function, physical function and material life status in the two groups after intervention were higher than those before intervention, with statistically significant differences (P＜0.05).After intervention,the scores of social function, psychological function, physical function and material life status of patients in the observation group were higher than those in the control group, and the differences were statistically significant (P＜0.05).Conclusion The application of behavioral impulse intervention nursing in patients with bipolar disorder treated by A620 brain therapeutic apparatus can improve their impulsive behavior and improve their quality of life.

Objective To discuss the application of narrative nursing in inpatients with stage Ⅱand Ⅲpneumoconiosis and the influence on patients' nursing satisfaction. Methods Fifty inpatients with stage Ⅱand Ⅲpneumoconiosis admitted to the Department of Respiratory Medicine, the Pingxiang Third People's Hospital from September 2020 to January 2022 were selected as the research subjects.They were divided into control group and observation group by random number table method,with 25 cases in each group.The control group received routine nursing,and the observation group received narrative nursing on this basis.Both groups were given 2 weeks of intervention.The psychological status and self-care ability of the two groups before and after intervention were compared, and the total nursing satisfaction of the two groups was compared. Results There were no statistically significant differences between the two groups in the self-rating anxiety scale (SAS) scores, the self-rating depression scale (SDS) scores and the exercise of self-care agency scale (ESCA) scores before intervention (P ＞0.05).After intervention, the SAS score and SDS score of observation group were lower than those of control group, and the ESCA score of observation group was higher than that of control group, the differences were statistically significant (P＜0.05).The total nursing satisfaction of the observation group (96.00%) was higher than that of the control group (72.00%), and the difference was statistically significant (P＜0.05). Conclusion Applying narrative nursing to inpatients with stage Ⅱand Ⅲpneumoconiosis can improve their psychological status, self-care ability and nursing satisfaction.

Objective To explore the influence of comfortable nursing on the psychological state and vital signs of patients undergoing hysteroscopy and hysteroscopic electrotomy. Methods From April 2018 to February 2021, 70 patients with hysteroscopy and hysteroscopic resection in Fuzhou Maternal and Child Health Hospital (Fuzhou Second People's Hospital) were selected as the research objects and divided into control group (35 cases) and observation group (35 cases) according to the random number table method.The control group received routine nursing intervention, and the observation group received comfort nursing intervention on this basis.The psychological stress state and physiological stress indexes before and after intervention were compared between the two groups. Results Before intervention, there were no significant differences in the scores of self-rating anxiety scale (SAS) and self-rating depression scale (SDS)between the two groups (P＞0.05).After intervention, the SAS and SDS scores of the two groups were lower than those before intervention, and the SAS and SDS scores of the observation group were lower than those of the control group,the differences were statistically significant (P＜0.05).The systolic blood pressure, diastolic blood pressure and heart rate of the observation group after intervention were lower than those of the control group, the differences were statistically significant (P＜0.05). Conclusion Comfortable nursing for patients with hysteroscopy and hysteroscopic resection can reduce their psychological stress reaction, improve the body stress indexes such as heart rate and blood pressure,which is worthy of clinical promotion.

Objective To investigate the factors influencing the prognosis of patients with multidrug-resistant bacteria infection in cardiac intensive care unit (ICU), and develop a nursing plan according to the risk factors. Methods Patients with multidrug-resistant bacteria infection who were admitted to cardiac ICU of Yingtan People's Hospital from February 2017 to July 2021 were selected as the research subjects.They were divided into survival group ((n=70)) and death group (n=28) according to the clinical outcome after 28 days of treatment.The data of survival group and death group was comparatively analyzed.logistic regression analysis was performed to screen the prognostic factors. Results A total of 98 patients were included in the study.There were statistically significant differences between survival group and death group in age, acute physiology and chronic health score Ⅱ(APACHE Ⅱ) and albumin level (P＜0.05).Multivariate analysis found that APACHE Ⅱ (β=0.124, OR=1.132, 95%CI=1.101-1.164) was an independent risk factor for poor prognosis in patients with multidrug-resistant infection in cardiac surgery ICU, albumin level (β=-0.145, OR=0.865, 95%CI=0.819-0.914) was an independent protective factor for poor prognosis in patients with multidrug-resistant bacterial infection in cardiac surgery ICU (P＜0.05). Conclusion Patients with multidrug-resistant bacteria infection in cardiac ICU have a high mortality rate.The severity of the disease and albumin level at admission are closely related to poor prognosis.For clinical nursing, it is advisable to assess the severity of the disease early, carry out risk grading management, closely monitor the patient's condition and deal with it in time.

Objective To explore the application effect of acupoint application of Rhubarb and Glauber's salt on noninvasive ventilation-related abdominal distension at the appointed time (7:00-9:00). Methods A total of 75 patients with chronic obstructive pulmonary disease (COPD) and abdominal distension using noninvasive ventilation admitted to Jurong City People's Hospital from March 2020 to March 2021 were selected as research objects, they were divided into control group (37 cases) and observation group (38 cases) according to random number table method.Both groups received acupoint application of Rhubarb and Glauber's salt on the basis of routine nursing.The application time of acupoints in the control group was any time during hospitalization, avoid the time period of 7:00-9:00, while the observation group used acupoint application at 7:00-9:00, the efficacy of abdominal distension, abdominal distension symptom score, immune indexes and blood gas were compared between the two groups before and after intervention. Results The total effective rate of abdominal distension after intervention in the observation group was higher than that in the control group, and the abdominal distension symptom score in the observation group was lower than that in the control group,the differences were statistically significant (P＜0.05).After intervention, the procalcitonin (PCT) and C-reactive protein(CRP) the observation group were lower than those before intervention, the differences were statistically significant(P＜0.05).There were no significant differences in PCT and CRP in the control group before and after intervention (P＞0.05).PCT and CRP in the observation group after intervention were lower than those in the control group, the differences were statistically significant (P＜0.05).After treatment, there were no significant differences in partial pressure of oxygen (PaO2), partial pressure of carbon dioxide in artery (PaCO2) between the two groups (P＞0.05).Conclusion Acupoint application of Rhubarb and Glauber's salt can effectively improve non-invasive ventilation-related abdominal distension and adjust the level of inflammatory factors, but the effect of ventilation needs further verification.

Objective To explore the application effect of continuous blood glucose meter monitoring in diabetic patients. Methods A total of 88 diabetic patients treated in New Mile General Hospital of Yankuang Group from August 2018 to June 2020 were selected as the research objects, and were divided into control group and observation group according to random number table method, with 44 cases in each group.The control group was given routine blood glucose monitoring, and the observation group was given dynamic blood glucose monitoring.Blood glucose level,quality of life, self-management ability and nursing satisfaction were compared between the two groups. Results There was no significant difference in blood glucose levels between the two groups before intervention(P＞0.05).After intervention,fasting blood glucose and 2 h postprandial blood glucose levels in the observation group were (5.88±1.47) and (8.13±1.64)mmol/L,which were lower than those in the control group (8.27±2.08)and (11.44±2.10)mmol/L,and the differences were statistically significant (P＜0.05).There was no significant difference in the world health organization quality of life(WHOQOL-BREF) score between the two groups before intervention (P＞0.05).The WHOQOL-BREF scores of the observation group were higher than those of the control group after intervention, and the differences were statistically significant (P＜0.05).There was no significant difference in self-care ability determination scale (ESCA) score between the two groups before intervention (P＞0.05).The ESCA scores of the observation group were higher than those of the control group after intervention, and the differences were statistically significant (P＜0.05).The nursing satisfaction of the observation group was 95.45%, higher than that of the control group 81.82%, and the difference was statistically significant (P ＜0.05). Conclusion The application effect of continuous blood glucose meter monitoring in diabetic patients is good, which can effectively improve patients' self-management ability, stabilize blood sugar level, improve patients' quality of life, and improve nursing satisfaction.

Objective To analyze the effect and satisfaction of cluster nursing in preventing inhalation injury from tracheotomy for cannula prolapse. Methods From September 2019 to September 2021, 90 patients with inhalation injury tracheotomy admitted to the No.910 Hospital of the Joint Logistics Support Force were selected as the research objects.They were divided into the study group and the control group according to random number table method, with 45 cases in each group.The patients in the control group were given routine nursing, and the patients in the study group were given cluster nursing.The incidence of tracheal cannula prolapse, the incidence of complications, the level of blood gas analysis indicators and the satisfaction score were compared between the two groups. Results The incidence of tracheal tube prolapse in the study group was lower than that in the control group, and the difference was statistically significant(P＜0.05).The total incidence of complications in the study group was lower than that in the control group, and the difference was statistically significant (P＜0.05).Before nursing, there were no statistically significant differences in the levels of power of hydrogen (pH), arterial carbon dioxide partial pressure (PaCO2), blood oxygen partial pressure (PaO2), and blood oxygen saturation (SpO2) between the two groups (P＞0.05).After nursing, the PaCO2 levels of the two groups were lower than those before nursing, and the PaO2 and SpO2 levels were higher than those before nursing, the pH level of the study was lower than that befer nursing, the pH and PaCO2 levels of the study group after nursing were lower than those of the control group, the PaO2 and SpO2 levels were higher than those of the control group, the differences were statistically significant (P＜0.05).The satisfaction score of the study group was higher than that of the control group, and the difference was statistically significant (P＜0.05). Conclusion The effect of cluster nursing on preventing the prolapse of the cannula in patients with tracheotomy for inhalation injury is significant, and the patient satisfaction is high.

Objective To explore the application effect of medication guidance based on mobile medical APP in the safe medication of elderly patients with chronic diseases. Methods A total of 120 elderly patients with chronic diseases who were treated in Kangmei Hospital from September 2020 to March 2021 were selected as the research objects, they were divided into control group (60 cases) and observation group (60 cases) according to the random number table method.The control group received conventional medication guidance, and the observation group received medication guidance based on mobile medical APP on the basis of the control group.The medication safety behavior, medication compliance and nursing satisfaction of the two groups before and after intervention were compared. Results There were no significant differences in medication safety behavior scores, the proportion of good and poor medication compliance,medication compliance and nursing satisfaction scores between the two groups before intervention (P ＞0.05).After intervention, medication safety behavior scores, the proportion of good medication compliance and nursing satisfaction scores of the observation group were higher than those of the control group, the differences were statistically significant(P ＜0.05). Conclusion Medication guidance based on mobile medical APP can improve medication safety behavior,medication compliance and nursing satisfaction of elderly patients with chronic diseases.