Objective To analyze the factors related to medication compliance of patients with epilepsy (EP) and mental disorder. Methods Sixty patients with EP and mental disorder who were admitted to the Third People's Hospital of Shangrao City from January 2019 to January 2022 were selected as the research subjects.The Morisky medication adherence scale (MMAS-8) was used to evaluate the patients' medication compliance, and they were were divided into group A (good compliance, n=38) and group B (poor compliance, n=22) according to compliance.The baseline data (gender, age, marital status, education level, occupation, social support, living pattern, living environment, family income,hospitalization times, etc.) were analyzed to investigate the reasons for poor medication compliance.Logistic regression analysis was conducted to screen the factors related to medication compliance of patients with EP and mental disorder.Results There were statistically significant differences between the two groups in living environment, monthly household income and hospitalization times (P＜0.05).Logistic regression analysis showed that monthly family income (β=1.021,OR=2.776, 95%CI=1.262-6.104) and living environment (β=0.964, OR=2.622, 95%CI=1.172-5.868) were influencing factors of patients' medication compliance (P＜0.05).Among the causes of poor medication compliance, the proportions of forgetting to take medicine for various reasons and thinking that taking medicine would be discriminated against were higher than 50%. Conclusion The main reasons for poor medication compliance of patients with EP and mental disorder include forgetting to take medication and thinking that taking medication will be discriminated against.The main influencing factors of patients' medication compliance include family income and living environment.