Objective To explore the influence of comfortable nursing on the psychological state and vital signs of patients undergoing hysteroscopy and hysteroscopic electrotomy. Methods From April 2018 to February 2021, 70 patients with hysteroscopy and hysteroscopic resection in Fuzhou Maternal and Child Health Hospital (Fuzhou Second People's Hospital) were selected as the research objects and divided into control group (35 cases) and observation group (35 cases) according to the random number table method.The control group received routine nursing intervention, and the observation group received comfort nursing intervention on this basis.The psychological stress state and physiological stress indexes before and after intervention were compared between the two groups. Results Before intervention, there were no significant differences in the scores of self-rating anxiety scale (SAS) and self-rating depression scale (SDS)between the two groups (P＞0.05).After intervention, the SAS and SDS scores of the two groups were lower than those before intervention, and the SAS and SDS scores of the observation group were lower than those of the control group,the differences were statistically significant (P＜0.05).The systolic blood pressure, diastolic blood pressure and heart rate of the observation group after intervention were lower than those of the control group, the differences were statistically significant (P＜0.05). Conclusion Comfortable nursing for patients with hysteroscopy and hysteroscopic resection can reduce their psychological stress reaction, improve the body stress indexes such as heart rate and blood pressure,which is worthy of clinical promotion.