Objective To analyze the effect and satisfaction of cluster nursing in preventing inhalation injury from tracheotomy for cannula prolapse. Methods From September 2019 to September 2021, 90 patients with inhalation injury tracheotomy admitted to the No.910 Hospital of the Joint Logistics Support Force were selected as the research objects.They were divided into the study group and the control group according to random number table method, with 45 cases in each group.The patients in the control group were given routine nursing, and the patients in the study group were given cluster nursing.The incidence of tracheal cannula prolapse, the incidence of complications, the level of blood gas analysis indicators and the satisfaction score were compared between the two groups. Results The incidence of tracheal tube prolapse in the study group was lower than that in the control group, and the difference was statistically significant(P＜0.05).The total incidence of complications in the study group was lower than that in the control group, and the difference was statistically significant (P＜0.05).Before nursing, there were no statistically significant differences in the levels of power of hydrogen (pH), arterial carbon dioxide partial pressure (PaCO2), blood oxygen partial pressure (PaO2), and blood oxygen saturation (SpO2) between the two groups (P＞0.05).After nursing, the PaCO2 levels of the two groups were lower than those before nursing, and the PaO2 and SpO2 levels were higher than those before nursing, the pH level of the study was lower than that befer nursing, the pH and PaCO2 levels of the study group after nursing were lower than those of the control group, the PaO2 and SpO2 levels were higher than those of the control group, the differences were statistically significant (P＜0.05).The satisfaction score of the study group was higher than that of the control group, and the difference was statistically significant (P＜0.05). Conclusion The effect of cluster nursing on preventing the prolapse of the cannula in patients with tracheotomy for inhalation injury is significant, and the patient satisfaction is high.