Objective To explore the value of 0.01% Aropine Eye Drops combined with frame glasses in controlling adolescent myopia. Methods A total of 118 adolescent myopia patients admitted to the First Affiliated Hospital of Jiangxi Medical College from March 2019 to March 2021 were selected retrospectively as research objects.According to the different treatment methods, they were divided into experimental group and control group, with 59 cases in each group.The control group was treated with frame glasses, and the experimental group was treated with 0.01% Atropine Eye Drops on the basis of control group.The intraocular pressure, tear film rupture time, axial length, diopter and adverse reactions (corneal epithelial spot dyeing, conjunctivitis, photophobia and corneal infection) were compared between the two groups.Patients with ocular adverse drug reactions after myopia treatment with 0.01% Atropine Eye Drops in the experimental group were included in the occurrence group, and patients without adverse drug reactions were included in the non occurrence group.The basic data of the two groups were compared, receiver operating characteristic (ROC) curve was used to analyze the value of 0.01% Atropine administration time in predicting ocular adverse drug reactions after myopia treatment, and the difference information between the two groups was incorporated into logistic regression analysis model, and the quantitative assignment was made to clarify the risk factors of ocular adverse drug reactions after myopia treatment with 0.01% Atropine Eye Drops. Results There were no significant differences in intraocular pressure, tear film rupture time,axial length and diopter between the two groups before and after treatment (P＞0.05).There was no significant difference in the incidence of corneal epithelial staining, conjunctivitis, photophobia and corneal infection between the two groups(P＞0.05).In the experimental group, 8 patients with eye drug adverse reactions after myopia treatment with 0.01% Atropine Eye Drops were included in the occurrence group, and 51 patients without occurrence were included in the nonoccurrence group.Univariate analysis showed that there were no significant differences in age, sex and family history of myopia between the two groups (P＞0.05).0.01% Atropine Eye Drops have statistically significant relationship with regular visual inspection, balanced nutrition, good eye habits and administration time (P＜0.05).Taking the occurrence of ocular adverse drug reactions after myopia treatment with 0.01% Atropine Eye Drops as dependent variable and statistically significant variables in univariate analysis as independent variables, logistic regression model was used for multivariate analysis.The results showed that no regular visual examination (β=0.436, OR=1.547, 95%CI=1.186-2.018), unbalanced nutrition (β=0.555, OR=1.742, 95%CI=1.279-2.373), poor eye habit (β=0.393, OR=1.481, 95%CI=1.037-2.115), long administration time (β=1.432, OR=1.540, 95%CI=1.016-2.204) were the risk factors of ocular adverse drug reactions after myopia treatment with 0.01% Atropine Eye Drops.ROC analysis confirmed that the AUC predicted by regular visual inspection, nutritional balance, eye habits and administration time were 0.830, 0.782, 0.862 and 0.911 respectively (P＜0.05). Conclusion There are many influencing factors of the occurrence of ocular adverse drug reactions after myopia treatment with 0.01% Atropine Eye Drops.We should regularly check the eyesight, keep good eye habits and strictly control the medication time to achieve better control of myopia.