Objective To explore the effect of increasing the pre-flushing cycle applied to severely poisoned patients with hemoperfusion (HP). Methods A total of 92 patients with severe HP poisoning admitted to the Second Affiliated Hospital of Hengyang Medical College of Nanhua University from April 2019 to June 2021 were selected as research objects.According to the random number table method, they were divided into control group and study group, with 46 cases in each group.The control group was given a static pre-filling method, and the study group was given a dynamic pre-filling method, compare the coagulation-related indicators and bleeding between the two groups. Results After perfusion, the activated partial thromboplastin time (APTT) and prothrombin time (PT) of the study group were shorter than those of the control group, and the fibrinogen (Fib) and platelet count (PLT) were higher than those of the control group, the differences were statistically significant (P＜0.05).The incidence of bleeding in the study group(2.17%) was lower than that in the control group (17.39%), and the difference was statistically significant (P＜0.05).Conclusion In patients with severe HP poisoning, increasing the pre-flushing cycle can reduce platelet loss after perfusion, thereby reducing the impact on coagulation function and the occurrence of bleeding at the puncture port.