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2020 Vol. 27, No. 34 Published: 2020-12-08

	4	Relationship between ABCB1 rs2032582 gene polymorphism and postoperative nausea and vomiting undergoing breast surgery
		SU Jian-sheng
		Objective To explore the relationship between ABCB1 rs2032582 gene polymorphism and postoperative nausea and vomiting undergoing breast surgery.Methods From December 2016 to January 2019,240 female patients who received breast surgery with general anesthesia in Fujian Medical University Union Hospital were selected as the subjects.Age,body mass index (BMI),history of motion sickness,history of postoperative nausea and vomiting,duration of anesthesia and occurrence of postoperative nausea and postoperative vomiting in early and later period (within first 6 hours and within 6 to 24 hours after surgery,respectively) were recorded.Improved multiple ligase detection reaction(iMLDR) was used for genotyping and relationship between ABCB1 rs2032582 gene polymorphism and postoperative nausea and vomiting was analyzed with logistic regression model.Results Patients carrying CT genotype had a 4.674 times greater risk of postoperative nausea than those carrying CC genotype in later period,CT genotype was a risk factor for postoperative nausea in later period (β=1.542,OR=4.674,95%CI=1.138-19.202,P＜0.05).Conclusion ABCB1 rs2032582 gene polymorphism had an association with postoperative nausea in later period,which may be one of important factors affecting female genetic susceptibility to postoperative nausea and vomiting undergoing breast surgery with general anesthesia.
		2020 Vol. 27 (34): 4-7 [Abstract] ( 32 ) HTML (1 KB) PDF (0 KB) ( 7 )

	8	Guiding value of serum lactate clearance rate and procalcitonin in the prognosis of children with severe pneumonia
		LIAO Jin-liang
		Objective To study the guiding value of serum lactate clearance rate and procalcitonin (PCT) in the prognosis of children with severe pneumonia.Methods A retrospective analysis of the data of 70 children with severe pneumonia admitted to the Third People′s Hospital of Huizhou from January 2018 to January 2020 was made,according to the prognosis of the children,the selected children were divided into the survival group (n=56) and the death group (n=14).The pediatric critical illness score (PCIS),serum PCT level and lactate clearance rate of children at 24 hours after admission between the two groups were compared,and the influence of PCT,lactate clearance rate and the interaction between the two on the prognosis of children and the guiding value were analyzed.Results The PCT of the death group was higher than that of the survival group,PCIS and the lactate clearance rate were lower than those of the survival group,and the differences were statistically significant (P＜0.05).The interaction of PCT,lactate clearance rate and both of them had an impact on the prognosis of children with severe pneumonia (P＜0.05).The PCT had higher guiding value for the prognosis of children with severe pneumonia (AUC＞0.9,P＜0.05),the critical value of 8.985 ng/mL,the sensitivity was 78.57%,and the specificity was 96.43%.The lactate clearance rate and the fitting had moderate guidance value for the prognosis of children with severe pneumonia (0.7＜AUC≤0.9,P＜0.05).The critical value of lactate clearance rate was 27.375%,the sensitivity was 91.07%,and the specificity was 78.57%;the fitting sensitivity of the two was 85.71%,and the specificity was 80.36%.Conclusion The serum lactate clearance rate and the PCT level have a definite effect on the prognosis of children with severe pneumonia and have moderate guiding value.
		2020 Vol. 27 (34): 8-11 [Abstract] ( 33 ) HTML (1 KB) PDF (0 KB) ( 12 )

	12	Effect of Mometasone Furoate Nasal Spray combined with Montelukast Sodium Chewable Tablets in the treatment of allergic rhinitis
		KUAI Ye-bin； ZHU Li-ping ；SHAO Bing-huan
		Objective To explore the effect of nasal hormone drugs combined with leukotriene receptor antagonists in the treatment of allergic rhinitis (AR) and the influence on patients′ nasal secretion eosinophils (EOS),serum immunoglobulin E (IgE),soluble ST2 (sST2) and related cytokines.Methods A total of 120 AR patients from January 2016 to May 2018 admitted to Changzhou Maternal and Child Health Hospital were selected as the research objects and divided into the combined group and the control group by the randomized block design,with 60 cases in each group.Both groups were given Mometasone Furoate Nasal Spray for treatment,the combined group was treated with Montelukast Sodium Chewable Tablets at the same time.The scores of nasal congestion symptom,sneezing symptom,nasal itching symptom,runny nose symptom,nasal EOS positive rate,serum IgE,interleukin-6 (IL-6),and interleukin-8 (IL-8) before and after treatment and clinical efficacy were compared between the two groups.Results After 4 weeks of treatment,the scores of nasal congestion symptom,sneezing symptom,nasal itching symptom and runny nose symptom in the combined group were lower than those in the control group,and the differences were statistically significant(P＜0.05).After 4 weeks of treatment,the nasal EOS positive rate,serum IgE,IL-6 and IL-8 levels in the combined group were lower than those in the control gr oup,and the differences were statistically significant (P＜0.05).The clinical efficacy of the combined group was better than that of the control group,and the di fference was statistically significant(P＜0.05).Conclusion The effect of Mometasone Furoate Nasal Spray combined with Mont elukast Sodium Chewable Tablets is better than that of mometasone furoate nasal spray in the treatment of AR patients.
		2020 Vol. 27 (34): 12-15 [Abstract] ( 33 ) HTML (1 KB) PDF (0 KB) ( 11 )

	16	Application of local Sodium Citrate anticoagulation in patients with high bleeding risk in ICU
		YANG Si-ping；ZHANG Jie；ZHAO Bing-zhen
		Objective To explore the application value of local Sodium Citrate anticoagulation in patients with high bleeding risk in intensive care unit (ICU).Methods From March 2016 to May 2018,56 patients with high bleeding risk admitted to the ICU of the Third Medical Center of PLA General Hospital were selected as the research subjects.According to the random number table method,they were divided into the control group (n=28) and the observation group(n=28).In the control group,local Heparin Sodium anticoagulation was used,and in the observation group,local Sodium Citrate anticoagulation was adopted.The coagulation status of the dialyzer and tubing,and the changes in related laboratory indicators were compared between the two groups.The incidence of complications during treatment for all patients was recorded.Results In the control group,blood purification was performed in 189 times,and in the observation group,the purification was performed in 201 times.The incidence and severity of coagulation in the dialyzer and tubing in the observation group were lower than those in the control group,and the differences were statistically significant (P＜0.05).Before treatment,there were no statistically significant differences in the indexes of Ca2+,serum Na+,bicarbonate (HCO3-),activated partial thromboplastin time (APTT),urea nitrogen (BUN) and serum creatinine (SCr) between the two groups (P＞0.05).After treatment,both groups successfully completed blood purification treatment.The APTT of the observation group was shorter than that of the control group at 8 and 12 h after treatment,HCO3-was higher than that of the control group at 12 h after treatment,and the differences were statistically significant (P ＜0.05).There were no statistically significant differences in other above-mentioned indicators after treatment between the two groups (P＞0.05).The incidence rates of hemorrhage aggravated and new bleeding in the observation group were lower than those in the control group,and the differences were statistically significant (P＜0.05).Conclusion The application effect of local Sodium Citrate anticoagulation in blood purification treatment of patients with high bleeding risk in ICU is remarkable.It can effectively improve the coagulation indicators of ICU blood purification with high bleeding risk,reduce bleeding risk,and save medical expenses for patients.It is worthy of promotion.
		2020 Vol. 27 (34): 16-20 [Abstract] ( 33 ) HTML (1 KB) PDF (0 KB) ( 12 )

	21	Immunologic characteristics of different antibody types in myasthenia gravis
		LUO Han； XU Qian-hui； WANG Qian； ZHAO Zeng-xia； LIU Chun-bai；HUANG Ying
		Objective To explore the clinical characteristics of different antibody types and the relationship with other immune factors in myasthenia gravis.Methods A total of 155 patients with myasthenia gravis （MG） who were admitted to Shenzhen People′s Hospital and Shenzhen Longhua District Central Hospital from January 2017 to December 2018 were enrolled in the study.The anti-acetylcholine receptor antibody (AChR Ab) and antibody to muscle-specific kinase(MuSK Ab) in serum were determined by enzyme-linked immunosorbent assay.Patients were divided into AChR Ab positive (+) MG group,MuSK Ab positive (+) MG group and double seronegative (DSN) MG group according to the expression of AChR Ab antibody and MuSK Ab.The clinical manifestations,laboratory tests,thymic pathology and treatment programs of the three groups were analyzed.Results Among the 155 MG patients included in this study,the composition ratios of AChR Ab (+)MG,MuSK Ab (+)MG,and DSN MG were 66.4%,8.4%,and 25.2% respectively.After comparison,MuSK Ab (+) MG group was more likely to involve the muscles of the ball than the remaining two groups,the difference was statistically significant (P＜0.05).There was no significant difference in the proportion of myasthenic crisis among the all groups (P＞0.05).The AChR Ab(+)MG group had a higher thyroid abnormality rate and autoantibody positive rate than the remaining two groups,and the difference was statistically significant (P＜0.05).The incidence of thymoma among the AChR Ab(+)MG group,MuSK Ab(+)MG group,and DSN MG group was 55.3%,23.1%,and 25.6%,respectively.Comparing each subgroup,the AChR Ab(+)MG group had a higher the incidence of thymoma than the remaining two groups,the difference was statistically significant (P＜0.05).Conclusion With the different expressions of AChR Ab and MuSK Ab,MuSK Ab(+)MG was more likely to present bulbar muscles or extraocular muscles and the muscles are more limited.AChR Ab (+)MG is prone to abnormal thyroid function and has a higer autoantibody positive rate.AChR Ab(+)MG are prone to be associated with thymoma.
		2020 Vol. 27 (34): 21-25 [Abstract] ( 34 ) HTML (1 KB) PDF (0 KB) ( 10 )

	26	Research progress of traditional Chinese medicine for ulcerative colitis #br#
	Research progress of traditional Chinese medicine for ulcerative colitis #br#[J]. 中国当代医药, 2020,27(34): 26-30')" href="#">	GUO Ling-long1 JIANG Xiao-yan；LI Juan-juan；ZHANG Chun-hong；LI Jing-wei；CHEN Jian-hong；HUANG Bin
		Ulcerative colitis (UC),as a refractory straight colon non-specific inflammatory bowel disease,has been listed by WHO as one of the modern refractory diseases,which seriously affects the normal life of patients.At present,there is no clear cure for Western medicine,and Chinese medicine has unique advantages in regulating immune function,repairing intestinal mucosa,and alleviating intestinal inflammation.This article discusses the research progress of traditional Chinese medicine in the treatment of UC from the aspects of etiology and pathogenesis,special prescription,traditional Chinese medicine,classification and treatment,acupuncture therapy,traditional Chinese medicine enema,acupoint embedding,traditional Chinese medicine foot bath,etc,and it was found that the mechanism of certain Chinese medicines for the treatment of UC may be to improve the immune function by regulating the balance of T lymphocyte subsets,adjust the level of brain-gut peptides to repair the gastrointestinal mucosa,inhibit tumor necrosis factor-α(TNF-α),interleukin (IL)-1,IL-6,IL-8,prostaglandin E2 (PGE2),Toll-like receptor 2 (TLR2) mRNA and TLR2 protein expression,reduce antineutrophil cytoplasmic Antibody (ANCA) content,Smad7 expression level and relieve intestinal inflammation,acupuncture may reduce intestinal mucosal damage by inhibiting the reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidases (NOXs)-reactive oxygen species (ROS)-NOD-like receptor protein 3(NLRP3) inflammatory body signaling pathway,acupoint embedding may reduce intestinal inflammation by inhibiting the mRNA and protein expression of 5-lipoxygenase (5-LOX) and NF-κB065.Traditional Chinese medicine enema and traditional Chinese medicine foot bath also have a certain auxiliary treatment effect on UC.Therefore,traditional Chinese medicine treatment of UC can effectively relieve the clinical symptoms of patients and improve the clinical treatment effect,which is worthy of further application and promotion.
		2020 Vol. 27 (34): 26-30 [Abstract] ( 32 ) HTML (1 KB) PDF (0 KB) ( 7 )

	31	Research progress of neoadjuvant chemotherapy and perioperative nursing for locally advanced esophageal cancer
		WU Ying-hong LIU Hui-ling
		Patients with esophageal cancer are already in the middle and advanced stage,and some have lost the opportunity of operation.Neoadjuvant chemotherapy is a research hotspot in the comprehensive treatment of locally advanced esophageal cancer in recent years,because it can reduce the size of the tumor and reduce its pathological staging.For locally advanced esophageal cancer patients for surgical opportunities,and will not increase postoperative complications,prolong the survival time.The regimen of neoadjuvant chemotherapy is constantly updated with the development of chemotherapeutic drugs,which achieves a better clinical effect and reduces the reaction of patients after chemotherapy.Because esophageal cancer limits its intake of nutrients,and the adverse reactions of chemotherapy to the body increase the nutritional risk and psychological burden of patients,perioperative nursing care of patients after neoadjuvant chemotherapy,in addition to routine postoperative nursing,more attention should be paid to patients′ nutritional level,psychological problems,and complications caused by chemotherapy.
		2020 Vol. 27 (34): 31-33 [Abstract] ( 36 ) HTML (1 KB) PDF (0 KB) ( 9 )

	34	Effect of bladder volume scanner and integrated physician-nurse-patient management mode on the recovery of neurogenic bladder function
		YAN Yin ；XU Zhen； TONG Hua-zhang； GUAN Xi-hong
		Objective To explore the effect of bladder volume scanner combined with integrated physician-nurse-patient management mode on the recovery of bladder function in patients with spinal cord injury.Methods From June 2017 to June 2019,120 patients with spinal cord injury accompanied by neurogenic bladder damage who were admitted to the First Affiliated Hospital of Nanchang University were selected and divided into the experimental group one,the experimental group two,the experimental group three and the control group by random number table method,30 cases in each group.Routine treatments such as drinking water plan,intermittent catheterization and bladder function retraining were performed in all groups.In the control group,routine treatment was used;in the experimental group one,a bladder volume scanner was added;in the experimental group two,integrated physician-nurse-patient management mode was added;in the experimental group three,a bladder volume scanner combined with an integrated physiciannurse-patient management mode was adopted.The intervention lasted three months.Before and after intervention,the residual urine volume of the bladder,the results of urinary system examination,and the recovery time of bladder function were observed and compared in the four groups.The treatment effect of the four groups were also analyzed and compared.Results After intervention,the residual urine volume of patients in the three experimental groups was less than that in the control group,and the difference was statistically significant (P＜0.05).Only one patient in the experimental group three had urinary tract infection,and the rate of urinary tract infection was lower than that of the control group (χ2=7.680,P=0.006).Both 4 cases presented with urinary tract infection in the experimental group one and experimental group two.Compared with the control group,the difference was not statistically significant (P＞0.05).The first reflex urination in the experimental group three was shortest,compared with other groups,and the difference was statistically significant (P＜0.05).In terms of bladder function reconstruction time,there was statistical difference between the experimental group three and the other groups (P＜0.05).Conclusion The bladder volume scanner in the treatment of patients with spinal cord injury and neurogenic bladder dysfunction can shorten the recovery time of bladder function,and meanwhile has obvious advantage in reducing urinary system infection.The bladder volume scanner combined with the integrated physician-nurse-patient management mode is more excellent,and is worthy of clinical recommendation.
		2020 Vol. 27 (34): 34-37 [Abstract] ( 29 ) HTML (1 KB) PDF (0 KB) ( 12 )

	38	Effect of Tai Chi cloud hands on cardiac rehabilitation after percutaneous coronary intervention
		FAN Qiu-yan ；DING Mei-zhou
		Objective To investigate the effect of Tai Chi cloud hands on cardiac rehabilitation after percutaneous coronary intervention.Methods A total of 86 patients who admitted to the Second Affiliated Hospital of Nanchang University for percutaneous coronary intervention (PCI) from December 2018 to December 2019 were selected as the research objects and divided into the control group and the study group according to the random number table method,with 43 cases in each group.The patients in the control group were treated with routine intervention,and the patients in the study group were treated with routine intervention and Tai Chi cloud hands.The quality of life,clinical symptom scores and cardiac function were compared between the two groups.Results There were no statistically significant differences in quality of life scale (SF-36) scores between the two groups before intervention (P ＞0.05).After intervention,the SF-36 scores of the two groups were higher than those before intervention,and the differences were statistically significant (P＜0.05).After intervention,the SF-36 scores of the study group were higher than those of the control group,and the differences were statistically significant (P ＜0.05).There were no statistically significant differences in clinical symptom scores between the two groups before intervention (P＞0.05).After intervention,the clinical symptom scores of the two groups were lower than those before intervention,and the differences were statistically significant (P＜0.05).After intervention,the clinical symptom scores of the study group were lower than those of the control group,and the differences were statistically significant (P ＜0.05).There were no statistically significant differences in levels of left ventricular end-diastolic volume (LVEDV) and left ventricular ejection fraction(LVEF) between the two groups before intervention (P＞0.05).After intervention,the levels of LVEDV of the two groups were lower than those before intervention,the levels of LVEF were higher than those before intervention,and the differences were statistically significant (P ＜0.05).After intervention,the level of LVEDV in the study group was lower than that in the control group,the level of LVEF was higher than that in the control group,and the differences were statistically significant (P＞0.05).Conclusion Tai Chi cloud hands on patients after PCI can improve the cardiac function index,improve the quality of life and reduce the clinical symptom score,it has the important significance and certain promotion value.
		2020 Vol. 27 (34): 38-41转45 [Abstract] ( 27 ) HTML (1 KB) PDF (0 KB) ( 7 )

	42	Clinical application of controlled low central venous pressure technique in the treatment of hepatectomy for intrahepatic bile duct stones
		GAN Qin ；SUN Ting-li ；LAN Guo； XING Shi-long ；LIU He-chun
		Objective To investigate the clinical effect of controlled low central venous pressure technique in the treatment of hepatectomy for intrahepatic bile duct stones.Methods A total of 86 patients with intrahepatic bile duct calculi treated by hepatectomy who admitted to Affiliated Jiujiang Hospital of Nanchang University were selected and divided into the control group and the observation group according to random number table method,with 43 cases in each group.The control group was administrated by intravenous infusion with conventional methods,and the observation group was administrated by intravenous infusion with controlled low central venous technique.The amount of intraoperative blood loss,blood transfusion,proportion of blood transfusion,postoperative plasma urea nitrogen (BUN),creatinine changes (Cr),infusion volume before liver resection,and hemodynamic indexes were compared between the two groups.Results The amount of intraoperative blood loss and blood transfusion in the observation group were less than those in the control group,the proportion of blood transfusion was less than that in the control group,and the differences were statistically significant (P＜0.05).There were no statistically significant differences in plasma BUN and Cr levels between the two groups of patients before and after surgery (P＞0.05).The infusion volume before liver resection in the observation group was less than that in the control group,the central vein pressure (CVP) was lower than that in the control group,and the differences were statistically significant (P＜0.05).There was no significant difference in heart rate(HR) between the two groups (P＞0.05).Conclusion Patients with intrahepatic bile duct calculi treated by hepatectomy administrated by intravenous infusion with controlled low central venous pressure technique can reduce intraoperative blood loss,blood transfusion and infusion volume,and is beneficial to the postoperative recovery of patients.
		2020 Vol. 27 (34): 42-45 [Abstract] ( 33 ) HTML (1 KB) PDF (0 KB) ( 14 )

	46	Expression and significance of serum leptin，omentin-1 and platelet endothelial cell adhesion molecule-1 in patients with early renal damage in essential hypertension
		ZHANG Lei； ZHU Mei-sheng； FENG Chao-liang； XUE Li； ZHOU Xiao-hui； MIAO Hai-jun； ZOU Ting；XIANG Xuan
		Objective To study the expression and significance of serum leptin (LEP),Omentin-1 and platelet endothelial cell adhesion molecule-1 (sPECAM-1) in patients with early renal damage in essential hypertension.Methods From March 2018 to October 2019,72 patients with primary hypertension and early renal impairment treated in the First Affiliated Hospital of Xinjiang Medical University were selected as group A,73 patients with simple early renal impairment as group B,81 patients with normal renal function of primary hypertension as group C,38 patients with physical examination at the same time as group D.Fasting blood glucose,triglyceride,total cholesterol,high-density lipoprotein (HDL),low densith lipoprotein (LDL),serum cystatin c (Cys-C),micro-albumin urine (MAU),blood urea nitrogen (BUN),creatinine (Cr),LEP,Omentin-1 and sPECAM-1 were analyzed in four groups.The ROC curve was used to analyze the efficiency of joint diagnosis of LEP,Omentin-1 and sPECAM-1.Results The MAU,BUN and Cr levels of the four groups from high to low were group A,B，C and D;the LEP,Omentin-1 and sPECAM-1 levels of the four groups from high to low were group A,B,C and D.The sensitivity and specificity of combined detection were higher than those of single detection.ROC curve showed that the critical values of LEP,Omentin-1 and sPECAM-1 of hypertensive early renal injury were 7.99,59.60 and 7.91 μg/L respectively.Conclusion Through the changes of LEP,Omentin-1 and sPECAM-1 levels,it has significant guiding significance for the early renal function damage patients with essential hypertension.
		2020 Vol. 27 (34): 46-48转52 [Abstract] ( 33 ) HTML (1 KB) PDF (0 KB) ( 11 )

	49	Effect of horizontal muscle strengthening and weakening combined with inferior oblique muscle weakening in treatment of children with strabismus
		SHAN Fei； WANG Li-juan； YANG Qing ；ZUO Xing
		Objective To explore the clinical effect of combined treatment of weakening of strengthening and horizontal muscles and weakening of oblique muscles treating children with strabismus.Methods A retrospective analysis of 60 children with strabismus admitted to Gao′an People′s Hospital,Jiangxi Province from January 2018 to January 2019,with 92 affected eyes,they were divided into control group (30 patients received horizontal muscle strengthening and weakening surgery,42 eyes) and research group (30 cases received horizontal muscle strengthening and weakening combined with oblique muscle weakening,50 eyes) according to the treatment method.The total treatment efficiency,strabismus degree,and intraoperative blood loss,recovery time,vision recovery time,and complications were compared between two groups.Results The total effective rate of treatment in the research group was 93.33%,higher than that in the control group of 70.00%,the difference was statistically significant (P＜0.05);before treatment,the difference in strabismus between the two groups was not statistically significant (P＞0.05).The strabismus degree of the research group after 1,3 and 6 months after operation was lower than that of the control group,the difference was statistically significant (P＜0.05);the comparison of the operation time between the two groups was not statistically significant (P＞0.05);the intraoperative blood loss in the research group was less than that in the control group,the difference was statistically significant (P＜0.05),the recovery time and the vision recovery time in the research group were shorter than those of the control group,the differences were statistically significant (P＜0.05).The total incidence of complications between the two groups was not statistically significant (P＞0.05).Conclusion Clinical treatment of children with strabismus may be given horizontal muscle strengthening and weakening combined with inferior oblique muscle weakening.The effect is outstanding,which can significantly improve the ocular surface symptoms and ocular surface index,shorten the postoperative recovery time,high safety,and then improve their life quality.
		2020 Vol. 27 (34): 49-52 [Abstract] ( 32 ) HTML (1 KB) PDF (0 KB) ( 10 )

	53	Application of porous plate in position of lateral position operation
		FENG Mei ；ZHANG Zhen ；LUO Xiao-hong； LIU Shu-fang
		Objective To explore the application effect of porous plate in position of lateral position operation.Methods Clinical data of 56 patients who were placed in the lateral position of hip surgery in Xingguo People′s Hospital from October 2017 to November 2019 were retrospectively analyzed.The patients were divided into the control group and the observation group according to whether or not a perforated plate was used,with 28 cases in each group.The perioperative indicators,complications,satisfaction rate of patients to the surgeon and the anesthetist were compared between the two groups.Results The operation time in the observation group was shorter than that in the control group,and the difference was statistically significant (P＜0.05).The number of fluoroscopy and bleeding volume in the observation group were less than those in the control group,and the differences were statistically significant (P＜0.05).The incidence of complications in the observation group was lower than that in the control group,and the difference was statistically significant (P＜0.05).The total satisfaction rate of the surgeon in the observation group was higher than that in the control group,and the difference was statistically significant (P＜0.05).The total satisfaction rate of the anesthetist in the observation group was higher than that in the control group,and the difference was statistically significant (P＜0.05).Conclusion The porous plate in hip surgery can effectively shorten the operation time,reduce the number of fluoroscopy and bleeding,and reduce the incidence of complications.
		2020 Vol. 27 (34): 53-55 [Abstract] ( 28 ) HTML (1 KB) PDF (0 KB) ( 10 )

	56	Effect of thrombolytic therapy in patients with acute ischemic stroke after awakening with magnetic resonance imaging DWI-FLAIR mismatch
		XIE Zhi-yong ；LI Cui-ping； JIANG Xiao-hong； KANG Xiao-feng ；YAN Yu-ying
		Objective To explore the effect of thrombolytic therapy in patients with acute ischemic stroke with magnetic resonance imaging DWI-FLAIR mismatch.Methods A total of 72 patients with acute ischemic stroke who admitted in Yudu People′s Hospital from June 2016 to June 2019 were selected as the research objects.There were 36 patients with an onset time of 4.5-6 h and positive magnetic resonance imaging (MRI) on DWI and FLAIR were divided into the routine group,36 patients with an onset time>6 h and a positive MRI on DWI and a negative FLAIR (MRI DWIFLAIR mismatch) were divided into the study group.Both groups were treated with thrombolytic therapy.The intracranial hemorrhage,neurological deficit status at different time points and prognosis status of the two groups were compared after treatment.Results There was no statistically significant difference in total incidence of intracranial hemorrhage between the two groups (P>0.05).There were no statistically significant differences in National Institutes of Health Stroke Scale（NIHSS） scores between the two groups before treatment,1 d after treatment and 1 week after treatment (P>0.05).There was no statistically significant difference in the prognosis ratio between the two groups (P>0.05).Conclusion For patients with acute ischemic stroke who are mismatched by MRI DWI-FLAIR,thrombolytic therapy has the same therapeutic effect and safety as patients with an onset time of 4.5-6 hours.
		2020 Vol. 27 (34): 56-58 [Abstract] ( 29 ) HTML (1 KB) PDF (0 KB) ( 15 )

	59	Clinical effect of Recombinant Human Thrombopoietin combined with methylprednisolone in the treatment of adult primary immune thrombocytopenia
		XU Hai-yan ；CHEN Zhong-lei ；ZHANG Feng-chun
		Objective To investigate the therapeutic effect of Recombinant Human Thrombopoietin (rhTPO) and methylprednisolone in the treatment of adult primary immune thrombocytopenia (ITP).Methods Eighty patients with ITP admitted to Suzhou Kowloon Hospital Affiliated to Shanghai Jiaotong University Medical School from March 2017 to December 2019 were selected as the research subjects.They were divided into an observation group (n=40) and a control group (n=40) according to the random number table method.Patients in the two groups received conventional treatment.Patients in the control group were additionally treated with Methylprednisolone on the basis of conventional therapy,and patients in the observation group were additionally treated with rhTPO on the basis of the control group.The changes in platelet count (PTL) and immune function of the two groups before and after treatment were compared.The occurrence of adverse reactions of the two groups was analyzed.Results The PTL levels of the two groups after treatment were higher than those before,and the differences were statistically significant (P＜0.05).The PTL level in the observation group after treatment was higher than that of the control group,and the difference was statistically significant(P＜0.05).The CD3+,CD4+,CD4+/CD8+values in the two groups after treatment were higher than those before treatment,and the differences were statistically significant (P＜0.05).The CD3+,CD4+,CD4+/CD8+ values of the observation group after treatment were higher than those of the control group,and the differences were statistically significant (P＜0.05).There was no statistically significant difference in the total incidence of adverse reactions between the two groups (P＞0.05).Conclusion The combination of rhTPO and methylprednisolone in the treatment of patients with ITP has a remarkable clinical effect.It can effectively increase the PTL of patients and improve the immune function with few adverse reactions and a certain degree of safety.
		2020 Vol. 27 (34): 59-61 [Abstract] ( 39 ) HTML (1 KB) PDF (0 KB) ( 14 )

	62	Effect of Ambroxol Hydrochloride on chronic bronchitis
		ZHAO Nan
		Objective To study the effect of Ambroxol Hydrochloride on chronic bronchitis.Methods A total of 200 patients of chronic bronchitis admitted to Tiemei General Hospital of Liaoning Health Industry Group from January 2018 to March 2019 were selected as the research objects,and they were divided into the observation group (100 cases)and the control group (100 cases) according to the drawing lots method.The observation group was treated with Ambroxol Hydrochloride,and the control group was treated with conventional drug therapy.Cough disappearance time,fever reduction time,dyspnea time,hospitalization time,forced expiratory volume in one second as percentage of predicted volume (FEV1%),forced expiratory volume in the first second (FEV1) and total effective rate were compared between the two groups.Results The cough disappearance time,antipyretic time,hospitalization time and dyspnea time of the observation group were shorter than those of the control group,the differences were statistically significant (P＜0.05);FEV1% and FEV1 of the observation group were higher than those of the control group,the differences were statistically significant (P＜0.05);the total effective rate of the observation group was higher than that of the control group,the difference was statistically significant (P ＜0.05).Conclusion Ambroxol Hydrochloride is effective in the treatment of chronic bronchitis.
		2020 Vol. 27 (34): 62-64 [Abstract] ( 29 ) HTML (1 KB) PDF (0 KB) ( 10 )

	65	Study on the characteristics of blood lipid parameters in patients with type 2 diabetes and obesity
		WU Ying-jie； WANG Mei
		Objective To discuss the characteristics of blood lipid parameters in patients with type 2 diabetes mellitus and obesity.Methods Retrospective analysis of 292 patients with type 2 diabetes admitted to the Endocrinology Department of the Affiliated Hospital of Liaoning University of Traditional Chinese Medicine from August 2019 to January 2020，they were divided into the obese group (96 patients) and the non-obese group (196 patients) according to whether or not comorbidly obese.The relevant clinical data of the two groups were compared,and the characteristics of lipid parameters in patients with type 2 diabetes mellitus and obesity were analyzed.Results In the obese group,triglycerides(TG),total cholesterol (TC),high density lipoprotein (HDL-C) levels,and TG/HDL-C value were higher than those of the non-obese group,the differences were statistically significant (P＜0.05).There were no significant differences in low density lipoprotein (LDL-C) level,TC/HDL-C value,and LDL-C/HDL-C value between the two groups (P＞0.05).Conclusion Compared with non-obese type 2 diabetes patients,type 2 diabetes mellitus combined obesity patients with higher TG,TC,HDL-C level and TG/HDL-C value.Understanding its characteristics is more conducive to comprehensive clinical management of patients with obesity and diabetes,drawing attention to obesity and effectively prevention and treatment of related complications.
		2020 Vol. 27 (34): 65-67 [Abstract] ( 29 ) HTML (1 KB) PDF (0 KB) ( 14 )

	68	Clinical effect of Pantoprazole Sodium Injection in the treatment of peptic ulcer with upper gastrointestinal bleeding
		LI Ye-huan
		Objective To explore the clinical effect of Pantoprazole Sodium Injection in the treatment of peptic ulcer with upper gastrointestinal bleeding.Methods A total of 200 patients with peptic ulcer and upper gastrointestinal bleeding admitted to People′s Hospital of Yangchun City,Guangdong Province from May 2016 to May 2017 were selected as the research subjects,and they were divided into the control group (n=100) and the observation group (n=100)according to random number table method,the control group was treated with conventional rehydration,and the observation group was treated with Pantoprazole Sodium Injection.The number of vomiting,the number of black stools,the total amount of bleeding,and the efficacy indicators were compared between the two groups.Results The number of vomiting and black stools in the observation group was fewer than that in the control group (P＜0.05).The total bleeding in the observation group was less than that in the control group (P＜0.05).The clinical effect was higher than that in the control group,and the difference was statistically significant (P＜0.05).Conclusion The treatment of Pantoprazole Sodium Injection for patients with peptic ulcer complicated by upper gastrointestinal bleeding is ideal.It can effectively alleviate the patient′s bleeding symptoms,to improve the quality of life of patients.
		2020 Vol. 27 (34): 68-70 [Abstract] ( 28 ) HTML (1 KB) PDF (0 KB) ( 9 )

	71	Relationship between homocysteine and carotid plaque in patients with acute cerebral infarction
		KONG Yang-qin
		Objective To investigate the relationship between serum homocysteine (Hcy) level and carotid plaque in patients with acute cerebral infarction.Methods A total of 86 patients with acute cerebral infarction admitted to the First People′s Hospital of Fuzhou City from May 2018 to February 2020 were selected as the experimental group (16 cases without carotid plaque,70 cases with carotid plaque,and 42 cases with vulnerable plaque,28 cases with stable plaque),and 50 healthy people who underwent routine physical examination in the First People′s Hospital of Fuzhou City during the same period were selected as the control group.Venous blood was collected and serum Hcy level was measured.The difference of Hcy levels in different groups was compared.The Hcy levels in patients with acute cerebral infarction with or without carotid plaque,vulnerable plaque and stable plaque were observed,and the correlation between Hcy level and carotid intima-media thickness (IMT) in patients with acute cerebral infarction was observed.Results The level of Hcy in the experimental group was higher than that in the control group,the difference was statistically significant (P＜0.05).The level of Hcy in the carotid plaque group was higher than that in the non carotid plaque group,the difference was statistically significant (P＜0.05).The level of Hcy in the vulnerable plaque group was higher than that in the stable plaque group,the difference was statistically significant (P＜0.05).The level of Hcy in patients with acute cerebral infarction was positively correlated with IMT (r=0.278,P＜0.05).Conclusion The level of serum Hcy is closely related to the occurrence of acute cerebral infarction and the formation of carotid plaque.The increase of serum Hcy level can reflect the nature of carotid plaque.Monitoring the progress of serum Hcy level can effectively evaluate the condition and prognosis of patients.
		2020 Vol. 27 (34): 71-73转77 [Abstract] ( 31 ) HTML (1 KB) PDF (0 KB) ( 10 )

	74	Effect of abdominal acupuncture in the treatment of spastic paralysis after cerebrovascular disease
		WANG Jie-hua
		Objective To explore the clinical effect of abdominal acupuncture in the treatment of spastic paralysis after cerebrovascular disease.Methods A total of 90 patients with spastic paralysis after cerebrovascular disease in Quanzhou First Hospital from December 2018 to June 2020 were selected and divided into the control group (45 cases)and the observation group (45 cases) according to different treatment methods.The control group was treated with Bobath therapy,while the observation group was treated with abdominal acupuncture combined with Bobath therapy.The clinical therapeutic effect,degree of limb spasm,limb motor function and activities of daily living were compared between the two groups.Results The total effective rate of the observation group was 95.56%,which was higher than 77.78% of the control group,the difference was statistically significant (P＜0.05).The score of degree of limb spasm of the observation group after treatment was (6.42±0.23) points,which was lower than (8.59±0.46) points of the control group,the difference was statistically significant (P＜0.05).After treatment,the limb motor function score of the observation group was (0.68±0.17) points,which was lower than (1.23±0.22) points of the control group,the difference was statistically significant (P＜0.05).The score of activities of daily living in the observation group after treatment was(79.75±2.65) points,which was higher than (68.69±4.21) points in the control group,the difference was statistically significant (P＜0.05).Conclusion Abdominal acupuncture has a significant effect in the treatment of spastic paralysis after cerebrovascular disease,which can reduce the degree of limb spasm,improve the ability of daily living and limb motor function,it is worthy of clinical application.
		2020 Vol. 27 (34): 74-77 [Abstract] ( 30 ) HTML (1 KB) PDF (0 KB) ( 10 )

	78	Clinical comparison of two kinds of tibial prosthesis rotation alignment techniques in total knee arthroplasty
		DONG Yue-fu1 WANG Guo-dong； ZHANG-Zhen；MOU Zhi-fang；JIANG Sheng-bo1；LIU Xu-dong； LIU-Jian
		Objective To investigate the clinical effect of two kinds of alignment technique in Total knee arthroplasty(TKA) on the reduction of rotation malalignment of tibial prosthesis.Methods A total of 60 cases who received primary TKA surgery in the Affiliated Lianyungang Hospital of Xuzhou Medical University(the First People′s Hospital of Lianyungang) from April 2015 to April 2019 were divided into groups A and B based on the simple random number table method,with 30 patients in each group.Group A: rotation alignment technique of tibial prosthesis based on Akagi line,Group B: based on Insall line.At the last follow-up,the clinical efficacy after TKA was evaluated according to knee society score (KSS),and the rotation angle of tibial prosthesis was measured using CT image data.Results A total of 60 patients were followed up for 12 to 48 months,with an average of (22.9±5.5) months.The KSS score at the last followup after operation was higher than that before the operation,and the difference was statistically significant (P＜0.05);there was no significant difference in the KSS score between the groups before and at the last follow-up (P＞0.05).There was no statistically significant difference in the overall excellent and good rate between the two groups (P＞0.05);at the last follow-up,the overall angle of external rotation of tibial prosthesis in the A group ([3.2±1.3]°) was better than that in the B group ([6.4±3.2]°),and the difference was statistically significant (P＜0.05).The external rotation angle of tibial prosthesis in A group was less than that in B group,and the internal rotation angle was greater than that in B group (P＜0.05).The ratio of external rotation of tibial prosthesis in group A was lower than that in group B,while the ratio of internal rotation was higher than that in group B,the difference was statistically significant (P＜0.05).Conclusion The technique based on Akagi line can effectively reduce the malalignment of tibial prosthesis after TKA,which is better than the technique based on Insall line method.
		2020 Vol. 27 (34): 78-80转84 [Abstract] ( 30 ) HTML (1 KB) PDF (0 KB) ( 8 )

	81	Effect observation of percutaneous transforaminal endoscopic discectomy in treatment of lumbar spinal stenosis
		ZHANG Xiao-hui ；ZHENG Ya-jing； ZHENG Lin
		Objective To investigate the effect of percutaneous transforaminal endoscopic discectomy (PTED) in treatment of lumbar spinal stenosis (SLSS).Methods A total of 60 patients with SLSS admitted to Shangrao Fifth People′s Hospital from January 2018 to December 2019 were selected.By random number table method,they were divided into two groups,namely a control group (30 cases) and an observation group (30 cases).The control group underwent traditional open surgery decompression and posterior lumbar interbody fusion,and observation group was treated with PTED.The clinical efficacy,clinical indicators,pain degree,lumbar function and complications of the two groups were compared.Results The clinical efficacy of patients in the observation group was better than that of the control group,and the total effective rate was higher than that of the control group,with statistically significant differences (P＜0.05).The length of incision,hospital stay and operation time in the observation group were shorter than those of the control group,and intraoperative blood loss was less than that of the control group,the differences were significant statistically(P＜0.05).The postoperative dysfunction index (ODI) score and the visual analogue scale (VAS) score of the two groups were lower than those before operation,the differences were significant statistically (P＜0.05);The ODI and VAS scores of the observation group after operation were lower than those of the control group,and the differences were statistically significant (P＜0.05).The total incidence of complications in observation group was lower than that in control group,and the difference was significant statistically (P＜0.05).Conclusion PTED has a significant effect on patients with SLSS.It has less trauma,can effectively relieve postoperative pain,improve lumbar spine function,is beneficial to the patients′postoperative recovery,and has fewer complications.PTED has a significant therapeutic effect on SLSS patients with less trauma,and can effectively relieve postoperative pain and improve lumbar function,which is conducive to the patients′ postoperative recovery,with fewer complications.
		2020 Vol. 27 (34): 81-84 [Abstract] ( 28 ) HTML (1 KB) PDF (0 KB) ( 12 )

	85	Effect comparison of negative pressure drainage and skin drainage on calcaneal fracture patients′ complications and incision healing
		GUO Ji-wei
		Objective To explore the effect of negative pressure drainage and skin drainage on calcaneal fracture patients′ complications and incision healing.Methods The medical records of 46 patients who underwent calcaneal fracture surgery in Kunshan Second People′s Hospital from August 2014 to November 2019 were retrospectively analyzed.According to the different drainage methods,they were divided into negative pressure drainage group (22 cases) and skin drainage group(24 cases).The total drainage volume,drainage placement time,drying time,incision healing time and the incidence of complications were compared between the two groups.Results The total drainage volume of patients in the negative pressure drainage group was more than that in the skin drainage group,the drainage time was longer than that of the skin drainage group,the drying time and incision healing time were shorter than those of the skin drainage group,and the differences were statistically significant (P＜0.05).The total incidence of complications in the negative pressure drainage group was lower than that in the skin drainage group,and the difference was statistically significant(P＜0.05).Conclusion Negative pressure drainage has thorough drainage,low complication rate,faster healing of patients′ incisions,and obvious advantages compared with skin drainage,which can be used clinically.
		2020 Vol. 27 (34): 85-87 [Abstract] ( 33 ) HTML (1 KB) PDF (0 KB) ( 11 )

	88	Effect of minimally invasive percutaneous bone plate osteotomy in the treatment of patients with middle and lower tibia fractures
		LING Yun
		Objective To explore the clinical effect of minimally invasive percutaneous plate osteosynthesis inthe treatment of middle and lower tibial fractures.Methods A total of 70 cases of middle and lower tibial fractures in Yuci District People′s Hospital from May 2019 to may 2020 were selected as research objects and according to the random number table method,they were divided into observation group (35 cases) and control group (35 cases).The observation group was treated with minimally invasive percutaneous plate osteosynthesis,while the control group was treated with conventional open reduction and intramedullary nailing.The intraoperative indexes,fracture treatment effect and perioperative complications of the two groups were compared.Results The operation time and fracture healing time of the observation group were shorter than those of the control group,intraoperative blood loss in the observation group was less than that in the control group,the differences were statistically significant (P＜0.05);the total excellent and good rate of clinical treatment in the observation group was higher than that in the control group,the difference was statistically significant (P＜0.05);the incidence of postoperative complications in the observation group was lower than that in the control group,the difference was statistically significant (P＜0.05).Conclusion Compared with conventional open reduction and intramedullary nailing,minimally invasive percutaneous plate osteosynthesis has the advantages of better operation effect,shorter operation time,faster postoperative recovery,less intraoperative blood loss and lower incidence of perioperative complications compared with conventional open reduction and intramedullary nailing.
		2020 Vol. 27 (34): 88-90 [Abstract] ( 30 ) HTML (1 KB) PDF (0 KB) ( 12 )

	91	Effect of Rivaroxaban combined with rapid rehabilitation exercise in total knee arthroplasty
		JIANG Peng
		Objective To explore the effect of Rivaroxaban combined with rapid rehabilitation exercise in total knee arthroplasty (TKA).Methods The chinical data of 73 patients with total knee arthroplasty who were treated in the orthopaedic department of Shenzhen Hospital of Southern Medical University from May 2016 to November 2019 were restrospectively analyzed.A total of 39 patients with rapid rehabilitation exercise were enrolled in the study group,another 34 patients without rapid rehabilitation exercise were enrolled in the control group.The coagulation function,antithrombin-Ⅲ(AT-Ⅲ) level,D-dimer (D-D) and the incidence of deep vein thrombosis (DVT) in lower limbs at 3 and 7 days after operation of the patients in the two groups were compared.Results There were no significant differences in D-D,thrombin time (TT),activated partial thromboplastin time (APTT) and prothrombin time (PT)between the two groups before operation (P＞0.05).There was no significant difference in the incidence of lower limbs DVT between the two groups at 3 days after operation (P＞0.05).The incidence of DVT in lower limbs of patients in the study group was lower than that of the control group at 7 days after operation,and the difference was statistically significant (P＜0.05).There were no significant differences in D-D,TT,APTT,PT,AT-Ⅲlevels between the two groups at 3 days after operation (P＞0.05).The D-D level of the research group was lower than that of the control group at 7 days after operation,and the difference was statistically significant (P＜0.05).The level of AT-Ⅲin the study group was higher than that of the control group at 7 days after operation (P＜0.05).There were no significant differences in TT,APTT and PT levels between the two groups at 7 days after operation (P ＞0.05).Conclusion Taking Rivaroxaban combined with rapid rehabilitation exercise can effectively reduce the postoperative D-D level and improve the blood flow speed,so as to effectively prevent the formation of DVT after total knee arthroplasty,and has little effect on the coagulation function,which is safe in clinical application and can be widely used in clinical practice.
		2020 Vol. 27 (34): 91-93 [Abstract] ( 31 ) HTML (1 KB) PDF (0 KB) ( 8 )

	94	Analysis of clinical data of 13 cases of tibial focus debridement and inactivated bone grafting for treatment of tibial fibrous dysplasia
		LIANG Fu-de
		Objective To analyze clinical data of tibial lesion removal and inactivated bone grafting in the treatment of tibial fiber fibrous dysplasia.Methods From January 2009 to December 2017,retropective analysis of the clinical data of 13 patients with fibial fibrous dysplasia (OFD) in Department of Orthopedics,the First Affiliated Hospital of Fujian Medical University,and all patients underwent tibial lesion removal,the posterior wall of the tibia was retained.The remaining bone defect was grafted with allogeneic bone.Results Thirteen patients had postoperative pathological findings suggesting interfibrous dysplasia.Four patients relapsed after initial curettage.Three of them recovered after surgery.And one case was followed up for 5 years after diagnosis of recurrence,and the lesion remained stable.From the analysis of age,9 patients were ≤5 years old,and 4 patients relapsed;4 patients were ＞5 years old,all had no recurrence.From the perspective of surgery approach,7 patients underwent local extra periosteal resection,of which 1 patients relapsed;7 patients underwent local subperiosteal resection,and 3 patients recurred.Six patients had surgical complications,including 3 cases of nonunion,2 cases of osteomyelitis,and 1 case of tibial deformity,all of which were cured after reoperation.It is important to note that in the 7 patients undergoing extra periosteal resection,more postoperative complications occurred (2 patients of which were osteomyelitis and 2 patients were nonunion).Conclusion For patients older than 5 years,extraperiosteally resection is recommended.Allogeneic bone grafting is simple in operation and less invasive,but has more complications.Autologous fibula transplantation may be a better choice.
		2020 Vol. 27 (34): 94-96转100 [Abstract] ( 29 ) HTML (1 KB) PDF (0 KB) ( 12 )

	97	Application of 3D printing technology in the selection of laparoscopic renal tumor surgery
		HUANG Jian-rong ；LI Xiao-yu； ZHAO Jian-jie； DENG Xiao-lin； DU Chuan-ce； ZHONG Jiu-qing
		Objective To investigate the application value of 3D printing technology in the selection of laparoscopic renal tumor surgery.Methods A total of 60 renal tumor patients who admitted to People′s Hospital of Ganzhou City,Jiangxi Province from August 2018 to October 2019 were selected as the research objects and divided into the control group and the observation group by random number table method,with 30 cases in each group.The control group achieved CT and MRI to draw up the surgical resection plan.The observation group achieved 3D printing technology combined with CT and MRI tomographic image to draw up the surgical resection plan.The operation time,blood flow blocking time,intraoperative bleeding volume,cut margin width,creatinine levels before and after operation,and the total incidence of adverse events were compared between the two groups.Results The operation time and blood flow block time of the observation group were shorter than those of the control group,the intraoperative bleeding volume was less than that of the control group,the cut margin width was shorter than that of the control group,and the differences were statistically significant (P＜0.05).Before surgery,there was no significant difference in creatinine level between the two groups (P＞0.05).At 3 d and 1 month after operation,the creatinine level of the two groups were lower than those before surgery,and the differences were statistically significant (P＞0.05).At 1 month after surgery,the creatinine levels of the two groups were lower than those at 3 d after operation,and the differences were statistically significant (P＜0.05).At 3 d and 1 month after operation,the creatinine levels of the observation group were lower than those in the control group,and the differences were statistically significant (P＜0.05).The total incidence of adverse events in the observation group was lower than that in the control group,and the difference was statistically significant (P＜0.05).Conclusion In laparoscopic renal tumor surgery,in addition to conventional CT and MRI auxiliary measures,3D printing technology can also be selected.The application of 3D printing technology is conducive to accurately grasp the scope of surgical resection,improve surgical efficiency,reduce intraoperative renal function damage and surgical risk,and improve the quality of surgery.
		2020 Vol. 27 (34): 97-100 [Abstract] ( 33 ) HTML (1 KB) PDF (0 KB) ( 10 )

	101	Application of quality control circle in improving the timely rate of chemotherapy for tumor patients
		TANG Juan
		Objective To explore the application effect of quality control circle in improving the timely rate of chemotherapy for tumor patients.Methods A total of 40 cancer patients admitted to the Department of Hematology of Shunde hospital of Southern Medical University from November to December 2018 were selected as the control group,and chemotherapy was carried out by routine procedures and methods,with a total of 100 chemotherapy treatments.From January to March 2019,74 cancer patients were selected as the quality control circle (QCR) group,who were treated with chemotherapy by the quality control circle activity program,with a total of 311 times of chemotherapy treatments.The timely rate of chemotherapy,the 6 dimensions concluded the circle members′ skills,mental development,team spirit,responsibility and honor,activity confidence,communication and coordination scores were compared between the two groups.Results The timely rate of chemotherapy in QCR group was higher than that in control group,and the difference was statistically significant (P＜0.05).After intervention,the scores of 6 dimensions concluded the circle members′ skills,mental development,team spirit,responsibility and honor,activity confidence,communication and coordination in QCR group were higher than those before intervention,and the differences were statistically significant (P＜0.05).Conclusion QCR activity can significantly improve the timely rate of chemotherapy for cancer patients,improve the comprehensive ability of circle members,and is worthy of clinical application.
		2020 Vol. 27 (34): 101-104 [Abstract] ( 31 ) HTML (1 KB) PDF (0 KB) ( 11 )

	105	Clinical application of the multidisciplinary team in the diagnosis and treatment of colorectal liver metastasis
		ZENG Hui-ming； XIAO Ling-hui； XIE Wei
		Objective To analyze and study the clinical application effect of multidisciplinary management (MDT) in the treatment of colorectal liver metastasis (CLMs).Methods A total of 42 patients with CLMs who treated in the First People′s Hospital of Huizhou City,Guangdong Province from January 2014 to April 2017 were selected as the research objects and divided into the control group and the observation group by random number table method,with 21 cases in each group.The control group was not achieved MDT,while the observation group was carried out multidisciplinary teamwork for diagnosis and treatment.The preoperative chemotherapy rate,chemotherapy completion conversion rate,surgical conditions and mortality rates of the two groups were compared.Results The preoperative chemotherapy rate and chemotherapy completion conversion rate of the observation group (95.23%,80.95%) were higher than those of the control group (58.33%,53.33%),and the differences were statistically significant (P＜0.05).The proportion of primary resection or ablation in the observation group (76.92%) was higher than that of the control group (27.58%),and the difference was statistically significant (P ＜0.05).The surgical resection rate of metastases in the observation group(75.00%) was higher than that in the control group (33.33%),and the difference was statistically significant (P＜0.05).There were no statistically significant differences in R0 resection rate,lymph node dissection rate,metastasis dissection rate and pathological complete remission rate between the two groups (P＞0.05).The 1-year follow-up mortality rate of the observation group and the control group were 4.76% (1/21) and 9.52% (2/21).There was no statistically significant difference in the 1-year follow-up mortality rate between the two groups (P＞0.05).The 2-year follow-up mortality rate of the observation group and the control group were 38.09% (8/21) and 61.90% (13/21).The 2-year follow-up mortality rate of the observation group was lower than that of the control group,and the difference was statistically significant (P＜0.05).Conclusion The MDT model of multiple methods for sequential treatment of CLMs obtains a definite effect,which is conducive to standarde patient′s preoperative examination and intraoperative chemotherapy,and has a remarkable effect on improving the resection and ablation rate and the resection rate of metastases.It is worthy of clinical promotion and application.
		2020 Vol. 27 (34): 105-107转117 [Abstract] ( 32 ) HTML (1 KB) PDF (0 KB) ( 9 )

	108	Effect of Jianpi Sanjie Decoction in the treatment of middle and advanced esophageal cancer
		WANG Ping； SU Zhi-hong
		Objective To investigate the effect of Jianpi Sanjie Decoction in the treatment of middle and advanced esophageal cancer.Methods A total of 60 patients with middle and advanced esophageal cancer who admitted to People′s Hospital of Dexing City,Jiangxi Province from July 2013 to July 2019 were selected as the research objects and divided into the study group and the control group by random number table method,with 30 cases in each group.The control group was treated with conventional chemotherapy,while the study group was treated with Jianpi Sanjie Decoction.The therapeutic effect and the total incidence rate of adverse reactions in the two groups were compared.Results The total effective rate of the treatment group was higher than that of the control group,and the difference was statistically significant (P＜0.05).The total incidence rate of adverse reactions of the study group was lower than that of the control group,and the difference was statistically significant (P＜0.05).Conclusion The therapeutic effect of Jianpi Sanjie Decoction for middle and advanced esophageal cancer is ideal,which can improve the therapeutic effect of patients,inhibit the further proliferation and proliferation of tumor cells,enhance the anti-tumor effect,and effectively reduce various adverse reactions of patients during chemotherapy.It is worthy of clinical promotion and application.
		2020 Vol. 27 (34): 108-110 [Abstract] ( 36 ) HTML (1 KB) PDF (0 KB) ( 11 )

	111	Effect of Antinib Hydrochloride Capsules in the treatment of advanced non-small cell lung cancer
		WEI Zhao-guang； CHENG Yan-lin； WANG Chang-qing； HE Ai-jun
		Objective To investigate the clinical effect of Anlotinib Hydrochloride Capsules in the treatment of advanced non-small cell lung cancer.Methods A total of 86 patients with advanced non-small cell lung cancer who admitted to Bao′an District People′s Hospital of Shenzhen City from May 2016 to May 2018 were selected as the research objects and divided into the control group and the study group by random number table method,with 43 cases in each group.The control group was treated with placebo,while the study group was treated with Anlotinib Hydrochloride Capsules.The time of tumor progression or death (PFS),total survival time (OS),clinical effect and total incidence of adverse events (AEs) were compared between the two groups.Results The PFS and OS in the study group were longer than those in the control group,and the differences were statistically significant (P＜0.05).The clinical effect of the study group was better than that of the control group,and the difference was statistically significant (P＜0.05).There was no statistically significant difference in total incidence of AEs between the two groups (P＞0.05).Conclusion The clinical effect of Anlotinib Hydrochloride Capsules in the treatment of advanced non-small cell lung cancer is better,it can effectively extend the patients′ progression-free survival time,and has good tolerance,but in terms of safety,evaluation of the scope of the study still needs to be further expanded.
		2020 Vol. 27 (34): 111-113 [Abstract] ( 27 ) HTML (1 KB) PDF (0 KB) ( 15 )

	114	Analysis of the clinical value of transvaginal color ultrasound in monitoring follicular growth and guiding the treatment of infertility WANG Hai-ying
	Analysis of the clinical value of transvaginal color ultrasound in monitoring follicular growth and guiding the treatment of infertility WANG Hai-ying [J]. 中国当代医药, 2020,27(34): 114-117')" href="#">	WANG Hai-ying
		Objective To explore the clinical value of transvaginal color ultrasound in monitoring follicular growth and guiding the treatment of infertility.Methods A total of 100 patients with infertility treated in Jiujiang Maternal and Child Health Hospital,Jiangxi Province from January to December 2019 were selected and divided into control group(n=50) and study group (n=50) according to random number table method.The control group was examined by traditional ovulation test paper and transabdominal ultrasound,and the study group was examined by transvaginal color ultrasound.The diameter of preovulatory follicles,the growth rate of follicles,the thickness of endometrium one day before ovulation,the rate of follicular development and maturity,the rate of pregnancy,the thickness of endometrium,the resistance index of blood flow spectrum (RI) and the peak velocity ratio of diastolic blood pressure of umbilical artery were compared between the two groups.Results There were no significant differences in follicular diameter,follicular growth rate and endometrial thickness one day before ovulation between the two groups (P＞0.05).The follicular development and maturity rate of the study group was 64.00%,higher than that of the control group of 38.00%,and the pregnancy rate 48.00%,which was higher than that of the control group (22.00%),the differences were statistically significant (P＜0.05).The thickness of endometrium in patients with ovulation induction cycle was larger than that in natural cycle,and RI and spicer D were better than those in natural cycle,the differences were statistically significant (P＜0.05).Conclusion The development of follicles is closely related to conception.Transvaginal color ultrasound can observe the development of follicles noninvasively,intuitively and repeatedly,which is helpful to shorten the observation distance with ovaries and other uterine appendages,and avoid the interference of many external factors,in order to provide more accurate imaging information.Transvaginal color ultrasound is of significant clinical value and is worth further popularizing.
		2020 Vol. 27 (34): 114-117 [Abstract] ( 32 ) HTML (1 KB) PDF (0 KB) ( 14 )

	118	Effect of training of strong concept during pregnancy and strong intervention during labor on the result of labor
		MA Qiong
		Objective To discuss the effect of the training of strong concept during pregnancy and the strong intervention during labor on the maternal turnover of delivery.Methods During the antenatal examination in the Second Affiliated Hospital of Nanchang University from March 2018 to March 2019,462 cases of parturient without pregnancy complication were selected.The conditions of vaginal delivery were evaluated again,excluding cephalopelvic asymmetry,macrosomia and oligohydramnios,31 cases in each group were excluded and finally included in the control group (n=200) and the observation group (n=200).The control group was treated with routine antenatal examination and labor monitoring.In the observation group,the antenatal examination increased the knowledge training of cognition-beliefbehavior adjustment in the strong conceptual structure of the midwifery clinic,and carried out strong intervention in the course of labor.The self-rating anxiety scale during the first antenatal examination,the number of cases of doctor-patient cooperation,the time of active stage of the first stage of labor and the second stage of labor,the degree of vaginal laceration and the mode of delivery were evaluated by self-rating anxiety scale during the first antenatal examination.Results The score of self-rating anxiety scale in the observation group was lower than that in the control group (P＜0.05),the total rate of doctor-patient cooperation in the observation group was higher than that in the control group,and the time of the first active stage and the second stage of labor in the observation group were shorter than those in the control group;the degree of vaginal laceration was lighter than that of the control group,the rate of lateral perineal incision was lower than that of the control group,and the outcome of delivery was better than that of the control group,the differences were statistically significant (P＜0.05).Conclusion Instilling strong concept into parturients from the start of the pregnancy with strong intervention in labor can significantly reduce maternal pain and anxiety during labor and establishes parturients′ confidence in natural labor,therefore parturients cooperate with labor management actively,and the natural delivery rate is improved as well.
		2020 Vol. 27 (34): 118-121 [Abstract] ( 29 ) HTML (1 KB) PDF (0 KB) ( 12 )

	122	Effect of Zishen Yutai Pills on the endometrial receptivity and pregnancy rate of Clomiphene Citrate cycle
		ZHAO Ying； LIU Zhao-xia； WANG Qin； LIAO Ying
		Objective To investigate the effect of Zishen Yutai Pills on endometrial receptivity and pregnancy rate of Clomiphene Citratecycle.Methods A total of 90 patients with ovulatory infertility admitted to the First Affiliated Hospital of Gannan Medical University from December 2017 to June 2019 were selected as the research objects,and were divided into control group (45 cases) and observation group (45 cases) according to the double-blind method.The control group was treated with Clomiphene Citrate and the observation group was treated with Clomiphene Citrate+Zishen Yutai Pills.After 20 days of treatment,endometrial type,endometrial thickness,cervical mucus score,endometrial volume,spiral uterine artery pulse index (PI),resistance index (RI),clinical pregnancy,abortion rate and occurrence of adverse drug reactions were compared between two groups.Results The rates of endometrial A and B+C types before treatment in the two groups were not statistically significant (P＞0.05);the endometrial A rate of the observation group after treatment was higher than that of the control group,B+C type rate was lower than that in the control group,the differences were statistically significant (P＜0.05);there were no statistically significant differences in the endometrial thickness and cervical mucus score of ovulation day before treatment between the two groups (P＞0.05);atovulationday after treatment in the observation group the daily endometrial thickness and cervical mucus score were higher than those of the control group,the differences were statistically significant (P＜0.05).The endometrial volume,PI,RI index before treatment in the two groups were not statistically significant (P＞0.05);the endometrial volume of the observation group after treatment was higher than that of the control group,and the PI and RI indexes were lower than those of the control group,the differences were statistically significant (P＜0.05);the clinical pregnancy rate,miscarriage rate,and total rate of adverse drug reactions of the two groups,the differences were not statistically significant (P＞0.05).Conclusion Zishen Yutai Pills can promote Clomiphene Citrate uterine ovulation,improve endometrial receptivity,control low miscarriage rate,and have high drug safety,which has certain clinical application and promotion value.
		2020 Vol. 27 (34): 122-125 [Abstract] ( 32 ) HTML (1 KB) PDF (0 KB) ( 13 )

	126	Analysis of the risk factors of extrapulmonary complications in children with Mycoplasma pneumoniae infection
		WAN Fang ；CHEN Si
		Objective To analyze the risk factors of extrapulmonary complications in children with Mycoplasma pneumoniae infection.Methods The clinical data of 100 children with Mycoplasma pneumoniae infection who were treated in Pingxiang People′s Hospital,Jiangxi Province from February 2018 to November 2019 were retrospectively analyzed.All the children were assigned into groups according to the presence and absence of extrapulmonary complications,the clinical data of 55 children without extrapulmonary complications were included in control group,and the clinical data of 45 children with extrapulmonary complications were included in observation group.The risk factors for extrapulmonary complications in children with Mycoplasma pneumoniae infection were recorded and analyzed.Results The gender and duration of fever between the two groups were compared,and the difference was not statistically significant (P＞0.05).The proportion of age ＜6 years old,course of disease ＞14 d,start time of antibiotic use＞4 d,C-reactive protein (CRP) ＞10 mg/L,procalcitonin (PCT) ＞0.25 ng/mL,and pulmonary consolidation shadow in the observation group was higher than that in the control group,with statistical differences (P＜0.05).The results of Logistic multivariate analysis showed that age ＜6 years old,course of disease ＞14 d,start time of antibiotic use ＞4 d,CRP ＞10 mg/L,PCT ＞0.25 ng/mL,and pulmonary consolidation shadow were the risk factors for extrapulmonary complications in children with Mycoplasma pneumoniae infection (OR＞1,P＜0.05).Conclusion Younger age,longer course of disease,delayed start time of antibiotic use,elevated CRP,elevated ESR,and occurrence of pulmonary consolidation shadow are the risk factors for extrapulmonary complications in children with Mycoplasma pneumoniae infection.
		2020 Vol. 27 (34): 126-128 [Abstract] ( 30 ) HTML (1 KB) PDF (0 KB) ( 11 )

	129	Advantages and safety of laparoscopic treatment of acute abdomen in children
		HUANG Ke-chu ；ZHENG Zhen-hua ；YOU En-long； WU Zhen-zhen； CHEN Du-jian ；CHEN De-xu； LUO Zeng-jun
		Objective To explore the advantages and safety of laparoscopic treatment of acute abdomen in children.Methods The data of 837 children with acute abdomen treated in Sanming First Hospital Affiliated to Fujian Medical University from October 2016 to August 2019 were retrospectively analyzed,and were divided into two groups according to different surgical methods,in which 468 cases as observation groups were treated with laparoscopic surgery and 369 cases as the control group was treated with open surgery.The surgical indexes,treatment effects and complications of the two groups were compared.Results The intraoperative blood loss was (23.51±1.21) mL of the observation group,which was less than that of the control group of(38.89±1.57)mL,the operation time was(48.52±1.32)min,and the anal exhaust time was (2.05±0.35) d,hospitalization time was (5.11±1.24) d,which were shorter than those of the control group of (89.85±1.54) min,(4.65±1.24) d,(7.69±1.54) d,the differences were statistically significant (P＜0.05).The treatment total effective rate of the observation group was 98.93%,higher than that in the control group of 90.51%,which was statistically significant (P＜0.05).The total complication rate of the observation group was 2.35%,lower than that in the control group of 13.82%,the difference was statistically significant (P＜0.05).Conclusion The use of laparoscopic surgery in the treatment of acute abdomen in children is safer,and it can shorten the length of hospitalization and surgery,and improve the overall efficiency of treatment.It is worthy of promotion.
		2020 Vol. 27 (34): 129-131转144 [Abstract] ( 32 ) HTML (1 KB) PDF (0 KB) ( 13 )

	132	Effect of different staining methods of Trypan Blue on phacoemulsification of cataract
		CHEN Li ；ZHU Jie
		Objective To investigate the application effect of different staining methods of Trypan Blue during and after phacoemulsification of cataract.Methods From March 2017 to October 2019,60 patients (60 eyes) with total cataract admitted to the First Hospital of Nanping City in Fujian Province were selected as the research objects,and they were divided into group A (20 cases) and group B (20 cases) and group C (20 cases) according to the random lottery method.Group A used direct staining method,group B used bubble staining method,and group C used viscoelastic staining method.The anterior capsule staining of the three groups was observed,and the success rate of continuous curvilineal capsulorrhexis (CCC),posterior lens capsule rupture,corneal edema,visual acuity and corneal endothelial counts before and after surgery were compared in the three groups.Results There were no significant differences in the staining of the anterior capsule,the success rate of CCC,the rupture of the posterior capsule,the postoperative visual acuity,corneal edema,and postoperative corneal endothelial counts among the three groups (P＞0.05).The corneal endothelial counts in the three groups after surgery were lower than those before surgery,and the visual acuity was higher than that before surgery,the differences were statistically significant (P＜0.05).Conclusion The three staining methods of Trypan Blue have no obvious difference during and after surgery,while the direct staining method is simple to operate and has obvious effect,which is worthy of promotion.
		2020 Vol. 27 (34): 132-134 [Abstract] ( 28 ) HTML (1 KB) PDF (0 KB) ( 10 )

	135	Clinical effect of endoscopic sinus surgery combined with drugs in the treatment of chronic sinusitis with nasal polyps
		WANG Su-lan
		Objective To explore the clinical effect of endoscopic sinus surgery combined with antibiotics and intranasal hormone Budesonide in the treatment of patients with chronic sinusitis and nasal polyps.Methods A total of 50 patients with chronic sinusitis and nasal polyps who were admitted to Wuxi No.8 People′s Hospital from January 2016 to December 2018 were selected as the research objects,according to the principle of random drawing,they were divided into group A (treated with endoscopic sinus surgery) and group B (combined with antibiotics and intranasal hormone Budesonide drug treatment on the basis of group A treatment),25 cases in each group.The amount of intraoperative blood loss and hospitalization time of the two groups were observed,the clinical efficacy of the two groups after treatment was compared,and the incidence of postoperative complications in the two groups was recorded.Results There was no significant difference in the amount of intraoperative blood loss between the two groups (P＞0.05).The hospitalization time of group B was shorter than that of group A,and the difference was statistically significant (P＜0.05).After treatment,the total clinical effective rate of group B (92.00%) and group A (84.00%) was not statistically different (P＞0.05).Compared with group A (20.00%),the total incidence of complications in group B (12.00%) was not statistically different (P＞0.05).Conclusion Endoscopic sinus surgery combined with antibiotics and intranasal hormone Budesonide in the treatment of patients with chronic sinusitis and nasal polyps can shorten their hospitalization time,have certain clinical effect,and have lower total incidence of complications.
		2020 Vol. 27 (34): 135-137 [Abstract] ( 24 ) HTML (1 KB) PDF (0 KB) ( 12 )

	138	Application value of 3.0 T high-field enhanced magnetic resonance scan in early scar pregnancy
		JIANG Wen-ting； WANG Wei； WANG Hong-jing；ZHAN Bo
		Objective To investigate the application value of 3.0 T high-field enhanced magnetic resonance (MR) scan in early scar pregnancy.Methods The clinical data of 62 patients with abnormal vaginal bleeding admitted to Shangrao People′s Hospital from January to December 2019 were retrospectively analyzed.3.0 T high-field magnetic resonance pelvic plain scan and 3.0 T high-field magnetic resonance pelvic plain scan + enhanced scan were performed respectively.The magnetic resonance imaging results were analyzed and the sensitivity,specificity and accuracy of the two methods were compared.Results A total of 50 cases of uterine pregnancy with early scarring were confirmed by surgery.Cesarean section scars were all located in the isthmus of the anterior wall of the uterus.A total of 43 cases showed simple and uniform T1WI low signal and T2W2I high signal,7 cases showed irregular T2WI signal,after contrast-enhanced scanning,which showed complete circular enhancement or incomplete edge enhancement.A total of 41 cases of early scar pregnancy were diagnosed after magnetic resonance pelvic plain scan,9 cases were missed,and 6 cases were misdiagnosed.After magnetic resonance pelvic plain scan + enhanced scan,48 cases were diagnosed early scar pregnancy,2 cases were missed,and 1 case was misdiagnosed.The sensitivity,specificity and accuracy of MR pelvic scan for early scar pregnancy diagnosis were 82.00%,50.00%,and 82.14%,which were lower than those of MR pelvic scan + enhanced scan (96.00%,91.67%,95.24%),the differences were statistically significant (P＜0.05).Conclusion 3.0 T high-field intensive MR enhanced scan has a high application value in early scar pregnancy.Plain scan can be effective and show the relationship between the pregnancy sac and the scar position,while the enhanced scan has a better display effect on the content and scar thickness,which can be used as an effective supplement of plain scan and guide clinical treatment.
		2020 Vol. 27 (34): 138-140 [Abstract] ( 31 ) HTML (1 KB) PDF (0 KB) ( 13 )

	141	Application and diagnostic value of 64-slice spiral CT pulmonary angiography in pulmonary embolism
		BAO Ya-xing
		Objective To explore the application and diagnostic value of 64-slice CT pulmonary angiography and postprocessing technique in pulmonary embolism.Methods A total of 31 patients with pulmonary embolism in Wuxi Fifth People′s Hospital from June 2017 to December 2019 were selected as the research objects.Siemens 64 slice CT axial enhanced scanning was used,and the original data were used for post-processing reconstruction,including multiplanar reconstruction (MPR),maximum density projection (MIP) and volume reconstruction (VR),and the image was analyzed and studied.Results There were 89 pulmonary arteries involved in pulmonary embolism.The direct signs of pulmonary embolism were intravascular complete and incomplete filling defect.The indirect signs were pulmonary wedge consolidation,pulmonary exudate,enlargement of the main pulmonary artery,enlargement of the right ventricle and pleural effusion.Conclusion 64-slice CT has high application and diagnostic value in the diagnosis of pulmonary embolism.
		2020 Vol. 27 (34): 141-144 [Abstract] ( 30 ) HTML (1 KB) PDF (0 KB) ( 13 )

	145	Clinical efficacy of Xiaochaihu Granules combined with HAART in the treatment of acquired immune deficiency syndrome
		YU Huang-peng； XU Huan-xin； PING Xiang-hua； ZHANG Fan； ZUO Sheng； ZHANG Jing
		Objective To investigate the clinical efficacy of Xiaochaihu Granules combined with highly active antiretroviral therapy (HAART) in the treatment of acquired immune deficiency syndrome.Methods A total of 80 cases of acquired immune deficiency syndrome patients treated in the Third People′s Hospital of Jiujiang City from June 2017 to October 2018 were selected as subjects.They were divided into treatment group and control group according to random number table method,40 cases in each group.The control group was treated with HAART,and the treatment group was treated with Xiaochaihu Granules on the basis of the control group.Both groups were treated continuously for 18 months.The immune function,clinical efficacy,success rate of immune reconstruction and adverse reactions were compared between the two groups.Results After treatment,the number of CD4+ T lymphocytes in the treatment group was (390.28±21.27) cells/μL,and the CD4+/CD8+ in the treatment group was (0.62±0.05),which were higher than those in the control group of (335.26±35.19) cells /μL and (0.46±0.03),and the differences were statistically significant (P＜0.05).The CD8+ T lymphocytes in the treatment group was (620.57±34.52) cells/μL,which was lower than (750.27±26.64) cells/μL in the control group,and the difference was statistically significant (P＜0.05).The total effective rate and the success rate of immune reconstruction in the treatment group were 90.00% and 82.50% respectively,which were higher than 70.00% and 60.00% of the control group,the differences were statistically significant (P＜0.05).The rates of headache and vomiting were not significantly different between the two groups (P＞0.05).The rates of nausea and marrow suppression in the treatment group were lower than those in the control group,and the differences were statistically significant (P＜0.05).Conclusion Xiaochaihu Granules combined with HAART in the treatment of acquired immune deficiency syndrome can enhance the therapeutic effect,improve the immune function,improve the success rate of immune reconstruction and reduce the incidence of adverse reactions.
		2020 Vol. 27 (34): 145-148 [Abstract] ( 35 ) HTML (1 KB) PDF (0 KB) ( 12 )

	149	Therapeutic effect comparison of Flupentixol Melitracen and Bailemian in the treatment of moderate and severe chronic obstructive pulmonary disease with anxiety or depression
		LE Liang ；FENG Xuan； NI Hong-yan
		Objective To compare the effect of Flupentixol Melitracen and Bailemian in the treatment of moderate and severe chronic obstructive pulmonary disease complicated with anxiety or depression.Methods From January 2017 to December 2019,150 patients with moderate and severe chronic obstructive pulmonary disease complicated with anxiety or depression treated in the Jingdezhen First People′s Hospital were selected as subjects.They were divided into three groups with 50 cases in each group by random number table method.The control group was given conventional symptomatic treatment,the observation group 1 was given conventional symptomatic treatment + oral Flupentixol Melitracen treatment,and the observation group 2 was given conventional symptomatic treatment + Bailemian treatment.The degree of anxiety and depression,quality of life,treatment effect and adverse reactions were compared among the three groups before and after 4 weeks of treatment.Results Comparison ofthe scores of hospital anxiety and depression scale(HADS),chronic obstructive pulmonary disease assessment test (CAT) and BODE index (B for body mass index,O for airflow obstruction,D for dyspnea,E for exercise ability) before treatment among the three groups showed no statistically significant differences (P＞0.05).After 4 weeks of treatment,the anxiety subscale score in the observation group 2 was(8.11±1.03) points,depression subscale score in the observation group 2 was (8.17±1.87) points,CAT score in the observation group 2 was (24.03±2.16) points,BODE index in observation group 2 was (4.25±0.62) points,were lower than those in the observation group 1 of (11.58±2.42),(10.49±2.38) (27.17±2.54),(5.98±0.79) points,and lower than those of the control group of (12.25±3.11),(12.12±3.09),(28.36±2.63),(6.48±0.85) points,the differences were statistically significant (P＜0.05).There was no significant difference in the total incidence of adverse reactions among the three groups (P＞0.05).Conclusion Bailemian treatment can improve the negative emotions of patients with moderate and severe chronic obstructive pulmonary disease complicated with anxiety or depression,improve the quality of life of patients,and has fewer adverse reactions,so it can be used as the first choice for clinical treatment.
		2020 Vol. 27 (34): 149-152 [Abstract] ( 25 ) HTML (1 KB) PDF (0 KB) ( 16 )

	153	Application of Ticagrelor,Heparin Sodium combined with Reteplase in acute ST-segment elevation myocardial infarction
		LIU Li-ping ；ZHANG Fu-sheng
		Objective To investigate the effect of Ticagrelor,Heparin Sodium combined with Reteplase on acute STsegment elevation myocardial infarction.Methods A total of 82 patients with acute ST-segment elevation myocardial infarction admitted to Ruijin People′s Hospital from September 2017 to September 2019 were selected as the study subjects.They were divided into comparison group(41 cases)and study group(41 cases)according to the method of "odd and even number table".The control group treated with Clopidogrel Bisulfate Tablets and Urokinase,the study group was treated with Ticagrelor,Heparin Sodium combined with Reteplase.The vascular recanalization rates at different moments,total incidence of adverse bleeding events and total incidence of cardiovascular adverse events during hospitalization were compared between the two groups.Results The vascular recanalization rates of patients in the study group at 60,90 and 120 min after thrombolysis were all higher than those in the control group,with statistically significant differences(P＜0.05).The total incidence of adverse bleeding events in the study group was lower than that in the control group,and the difference was statistically significant (P ＜0.05).The total incidence of cardiovascular adverse events was 12.20% in the study group,lower than 36.59% in the control group,and the difference was statistically significant (P＜0.05).Conclusion The treatment of Ticagrelor,Heparin Sodium combined with Reteplase in patients with acute STsegment elevation myocardial infarction can help to increase the recanalization rate of blood vessels and reduce the incidence of adverse events in different time periods after thrombolysis.It has high application value and security.
		2020 Vol. 27 (34): 153-156 [Abstract] ( 30 ) HTML (1 KB) PDF (0 KB) ( 11 )

	157	Experience analysis of professor CHEN Xiang-jun in treating rheumatoid arthritis
		HU Jian-Guo； CHEN Xiang-Jun
		Rheumatoid Arthritis(RA) is a chronic,inflammatory autoimmune disease mainly characterized by symmetrical arthritis,minor arthritis,and polyarthritis.RA can cause patients pain,disability,decreased quality of life,and death.Traditional Chinese Medicine in treating RA can bring hope to RA patients.This article analyzes the thoughts of Professor CHEN Xiang-jun in the treatment of RA in terms of the etiology and pathogenesis of RA,staged differentiation of symptoms and signs,rational use of insect medicines,the treatment method of the internal and external combined treatment of chinese herbs,and typical cases.It initially summarized Professor CHEN Xiang-jun′s diagnosis and treatment strategies,and medication experience based on therapeutic method of strengthening healthy qi,treatment method of the internal and external combined treatment of chinese herbs.It is expected to improve the efficacy of Traditional Chinese Medicine in treating RA.
		2020 Vol. 27 (34): 157-159转163 [Abstract] ( 31 ) HTML (1 KB) PDF (0 KB) ( 12 )

	160	Short-term effect of South Shaolin optimized scheme in the treatment of external humeral epicondylitis
		ZHAO Chang-yunlei； LIU Jun-ning；ZHANG Yan； LI Nan； NIU Su-sheng
		Objective To explore the short-term effect of South Shaolin optimization scheme on external humeral epicondylitis.Methods A total of fifty-eight patients with external humeral epicondylitis treated in the Department of Orthopaedics and Traumatology of the Third People′s Hospital Affiliated to Fujian University of Traditional Chinese Medicine and the Affiliated National Medical Hall Hospital from September 2017 to May 2019 were selected as the objects,according to the random number table method,they were divided into treatment group (n=29,31 elbows) and control group (n=29,30 elbows).The treatment group was treated with the optimized Sscheme of South Shaolin tendon therapy,external application of traditional Chinese medicine,self-massage and active functional exercise,while the control group was treated with health education,restricted activities and external application of Diclofenac Diethylamine Emulgel on the lateral epicondyle of humerus.The pain visual analogue scale (VAS) score,Mayo elbow function evaluation index (MEPS) before and after treatment,and efficacy after treatment were compared between the two groups.Results After treatment,the VAS scores of the two groups were lower than those before treatment,and the MEPS scores were higher than those before treatment,the differences were statistically significant (P＜0.05);there was no statistical difference in VAS scores between the two groups after treatment(P＞0.05).MEPS and total effective rate of the treatment group were higher than those of the control group,the differences were statistically significant (P＜0.05).Conclusion The short-term effect of South Shaolin optimized scheme in the treatment of external humeral epicondylitis is better,and the scheme has a unified and standardized standard,which is beneficial to the selection and use of grass-roots doctors and patients and the promotion of grass-roots hospitals.
		2020 Vol. 27 (34): 160-163 [Abstract] ( 26 ) HTML (1 KB) PDF (0 KB) ( 11 )

	164	Clinical effect on treating the third lumbar vertebral transverse foramen syndrome by Blade needle plus easy pot
		FENG Shao-ling； LI Wen-chun； PAN Qing-dong；XIE Wen-juan
		Objective To observe clinical effects of Blade needle plus Easy pot on the third lumbar vertebral transverse foramen syndrome.Methods A total of sixty patients with the third lumbar vertebral transverse foramen syndrome treated in our hospital from January 2018 to December 2018 were selected as research subjects.According to the random number lable method,the patients were divided into the treatment group (30 cases) and the control group (30 cases).The treatment group was treated with blade needle plus easy pot,and the control group was treated with Blade needle.The clinical effect,scores of visual analogue scale (VAS) and Japanese orthopaedic association (JOA) before and after treatment in the two groups were observed.Results After treatment,the VAS score after treatment of the treatment group was lower than that of the control group,and the difference was statistically significanl (P＜0.05).The JOA score of the treatment group was higher than that of the control group,and the difference was statistically significant(P＜0.05).The total effective rate of the treatment group was 86.7%,it was higher than that in the control group which accounting for 76.7%,the difference was statistically significant(P＜0.05).Conclusion Blade needle plus Easy pot on the third lumbar vertebral transverse foramen syndrome was effective，which can effectively relieve the patients′ pain.
		2020 Vol. 27 (34): 164-167 [Abstract] ( 33 ) HTML (1 KB) PDF (0 KB) ( 11 )

	168	Clinical effect of Dingchuan decoction in the treatmetment of chronic duration of bronchial asthma
		HUANG Kuan； ZHENG Zi-juan
		Objective To observe the clinical effect of Dingchuan decoction in the treatment of chronic duration of bronchial asthma.Methods A total of 120 cases of patients with chronic duration of bronchial asthma admitted to Hongdu Hospital of Traditional Chinese Medicine in Nanchang from January 2017 to January 2018 were selected,they were divided into two groups according to the random number table method,each had 60 cases.The patients in control group were treated with conventional western medicine,and the patients in observation group were treated with Dingchuan Decoction on the basis of the control group.The treatment effects of the two groups were compared.Results The effective rate of treatment in the observation group was 93.3%,higher than that in the control group which was 78.3%,the difference was statistically significant (P＜0.05).Lung function indexes including forced expiratory volume,forced vital capacity and maximum expiratory flow in the observation group were all higher than those in the control group,and the differences were statistically significant(P＜0.05).There was no significant difference in adverse reactions between the two groups(P＞0.05).Conclusion Dingchuan Decoction is used in the treatment of chronic persistent period of bronchial asthma,which can significantly improve the treatment effect of patients,improve lung function,and have fewer adverse reactions.Considering the patient's disease development and economic situation,when all conditions permit,Dingchuan Decoction can be given priority.
		2020 Vol. 27 (34): 168-170 [Abstract] ( 32 ) HTML (1 KB) PDF (0 KB) ( 9 )

	171	Study on the influence of kidney nourishing and dampness disinhibiting therapy on intestinal microecology of patients with rheumatoid arthritis
		JI Sen-guo ；ZHANG Xu-ming； WU Di； LIU Ju
		Objective To investigate the influence of kidney nourishing and dampness disinhibiting therapy on the intestinal microecology of patients with rheumatoid arthritis (RA).Methods A total of 80 RA patients treated in Jiujiang First People′s Hospital from January 2017 to December 2018 were selected as the research objects,and they were divided into the control group and the observation group according to random number table method,40 cases in each group.The control group was treated with Methotrexate,and the observation group was treated with Wangbi Tablets,all patients were treated for 3 months.The efficacy,intestinal flora diversity and safety indicators (adverse drug reactions,blood routine,urine routine,liver and kidney function) of the two groups were compared.Results After 3 months of treatment,the total effective rate of the observation group was 97.50%,which was higher than 80.00% of the control group,and the difference was statistically significant (P＜0.05).After 3 months of treatment,the uniformity of the intestinal flora of the observation group was (0.99±0.06) E,and richness of the intestinal flora of the observation group was(22.68±3.08) S,which were higher than those of the control group ([0.90±0.05]E and [19.36±2.16]S),the differences were statistically significant (P＜0.05).The incidence of adverse reactions in the observation group was 2.50%,which was lower than 20.00% in the control group,and the difference was statistically significant (P＜0.05).Conclusion Kidney nourishing and dampness disinhibiting therapy in the treatment of RA can significantly improve the therapeutic effect,restore the patients′ intestinal micro-ecological diversity,has higher safety of use of drug,can promote the recovery of patients,and which is worthy of promotion.
		2020 Vol. 27 (34): 171-174 [Abstract] ( 27 ) HTML (1 KB) PDF (0 KB) ( 13 )

	175	Value analysis of He-Ne Laser combined with fumigation and washing of Traditional Chinese Medicine in the treatment of vulvar squamous hyperplasia
		QIAN Dan； JIANG Fang-yan ；WU Xian-hua； HUANG Ling； HE Jian
		Objective To explore the value of He-Ne laser combined with Chinese medicine fumigation in the treatment of vulvar squamous epithelial hyperplasia.Methods A total of 80 patients with vulval squamous epithelial hyperplasia admitted to Shangrao Maternal and Child Health Hospital from February 2017 to February 2019 were selected and divided into observation group (n=40) and control group (n=40) according to the principle of random number table method.The patients in control group were treated with He-Ne laser.On the basis of the control group,the patients in observation group were treated with fumigation and washed with traditional Chinese medicine.Clinical efficacy,clinical symptom score,recurrence and adverse event incidence were compared between the two groups.Results The total clinical effective rate in the observation group was higher than that in the control group,and the difference was statistically significant (P＜0.05).Pruritus,dryness and desquamation scores of patients in the observation group after 1 month of treatment were all lower than those in the control group,with statistically significant differences (P＜0.05).The total recurrence rate of the observation group after 1 year follow-up was lower than that of the control group,and the difference was statistically significant (P＜0.05).No drug-related allergic reactions or other adverse reactions were found during the treatment.Conclusion He-Ne laser combined with traditional Chinese medicine fumigation can improve the clinical symptoms of patients with vulvar squamous epithelial hyperplasia,reduce the recurrence rate,and has high safety,which is worthy of clinical application
		2020 Vol. 27 (34): 175-178 [Abstract] ( 29 ) HTML (1 KB) PDF (0 KB) ( 12 )

	179	Squamous cell carcinoma antigen,neuron-specific enolase,carcinoembryonic antigen levels in patients with esophageal cancer and their relationship with clinicopathological factors
		ZHANG Cai-tian；XIE Er-fu
		Objective To explore the relationship between squamous cell carcinoma antigen (SCC),neuron-specific enolase (NSE),carcinoembryonic antigen (CEA) levels and clinicopathological factors in patients with esophageal cancer.Methods A total of 82 patients with esophageal cancer admitted to Yizheng People′s Hospital from May 2017 to May 2020 were selected as the observation group,and 90 healthy people who received physical examination during the same period were selected as the control group.The serum SCC,NSE and CEA levels were compared between the two groups.The serum SCC,NSE and CEA levels in patients with esophageal cancer with different clinicopathological characteristics were investigated,the factors affecting the serum SCC,NSE and CEA levels were analyzed.Results Serum SCC,NSE and CEA levels in the observation group were higher than those in the control group,and the differences were statistically significant (P＜0.05).There were no significant differences in serum SCC,NSE and CEA levels in patients with esophageal cancer of different genders and ages (P＞0.05).The patients with lymph node metastasis,high degree of differentiation,and TNM stages Ⅲand Ⅳhad higher serum SCC,NSE and CEA levels,the differences were statistically significant (P＜0.05).The levels of serum SCC,NSE and CEA were used as dependent variables,and lymph node metastasis,differentiation degree and TNM stage were used as independent variables for univariate linear regression analysis.The results showed that lymph node metastasis,degree of differentiation and TNM stage of tumor were the factors affecting the serum SCC,NSE and CEA levels in patients with esophageal cancer (P＜0.05).Conclusion SCC,NSE and CEA expression levels are higher in patients with esophageal cancer.Lymph node metastasis,degree of differentiation,and tumor TNM stage are factors that affect the serum levels of SCC,NSE and CEA in patients with esophageal cancer.
		2020 Vol. 27 (34): 179-181 [Abstract] ( 27 ) HTML (1 KB) PDF (0 KB) ( 11 )

	182	Evaluation value of D-dimer dynamic monitoring on the occurrence of deep venous thrombosis of lower limb in patients with lower limb fracture during perioperative period
		HUANG Yan； WANG Li-ping； CAO Yan-hong
		Objective To investigate the evaluation value of D-dimer dynamic monitoring for perioperative deep vein thrombosis (DVT) of lower limb in patients with lower limb fractures.Methods A retrospective analysis was performed based on the clinical data of 80 perioperative patients with lower limb fractures admitted to Xinyu Second Hospital from February 2019 to February 2020.All patients were treated with open reduction and internal fixation.According to whether the patients developed DVT after the operation,they were divided into a DVT group (n=8) and non-DVT group(n=72).The D-dimer level of the two groups was compared.The diagnostic efficiency of dynamic monitoring of Ddimer changes on the occurrence of lower limb fractures during the perioperative period was evaluated by receiver operating characteristic (ROC) curve.Results There was no statistically significant difference in D-dimer level between the two groups before operation (P＞0.05).The D-dimer levels at 1,3,7,and 14 d after operation in the two groups were all higher than those before surgery (P＜0.05).In the DVT group,the D-dimer levels of patients at 1,3,7,and 14 d after operation were higher than those in the non-DVT group,and the differences were statistically significant (P＜0.05).The ROC curve was drawn,and the results showed that the area under the ROC curve (AUC) value of the Ddimer levels of 1,3,7,and 14 d after the operation for the prediction of DVT in the perioperative period of lower limb fractures were 0.882,0.983,0.995,and 0.949.The D-dimer level at 1 day after operation has general diagnostic efficiency for DVT,and the D-dimer levels at 3,7 and 14 days after operation had a higher diagnostic efficiency after comparison.Conclusion D-dimer dynamic monitoring has high diagnostic efficiency for perioperative DVT in patients with lower limb fractures,and it can be used as an effective diagnostic tool for DVT.
		2020 Vol. 27 (34): 182-184 [Abstract] ( 27 ) HTML (1 KB) PDF (0 KB) ( 12 )

	185	Detection and result analysis of human papilloma virus genotyping in 9249 women in Xiamen area
		ZHANG Yu-feng；LEI Li-yun；LIN Yun；LUO Qiao
		Objective To analyze the situation of human papilloma virus (HPV) infection in women in Xiamen area,and analyze the distribution of various subtypes and their relationship with different ages.Methods The flow cytometry was used to detect HPV gene in the cervical exfoliated cells of 9249 women in Clinic of Department of Gynecology of Xiamen Hospital of Traditional Chinese Medicine from July 2018 to June 2019.The distribution of HPV genotype,single and multiple infection were analyzed,and the characteristics of HPV infection among different age groups were compared.Results A total of 1523 cases were positive for HPV in 9249 cases,the detection rate was 16.47%.The highest detection rate was 35.29% in the ＜20 age group,followed by 18.76% and 18.13% in the 20-＜30 age group and 60-＜70 age group,respectively.The top 7 subtypes of HPV infection were type 52,type 16,type 58,type 53,type 39,type 61 and type 81,which accounted for 71.24% of the total.HPV infection was mainly single infection,accounting for 75.38% of the total.Multiple infection was mainly double infection,accounting for 69.33% of the multiple infection.Conclusion The detection of HPV infection in high risk population by flow cytometry is not only rapid and accurate,but also can distinguish the subtypes of HPV infection.We should pay attention to the screening of HPV in women in Xiamen area,especially the screening of the four most common subtypes of HPV 52,16,58 and 53,which can effectively reduce the incidence of cervical cancer and other HPV related diseases.
		2020 Vol. 27 (34): 185-188 [Abstract] ( 32 ) HTML (1 KB) PDF (0 KB) ( 12 )

	189	Analysis of the status of nurses with low seniority and their sense of professional gain
		SHAO Yi-shen； WANG Yi-jia； LI Lu-huan； SHEN Juan
		Objective To analyze the occupational status and occupational benefit status of junior nurses,and explore the related factors.Methods According to the random sampling method,five Grade A hospitals in Suzhou and Nanjing were selected from June to October 2019,and 200 low-age nurses were randomly selected as subjects,and the occupational benefit questionnaire was used to conduct the survey.Results A total of 200 questionnaires were sent out,and those with more than 2 missing items in the questionnaire were deleted,and 197 copies were recovered.197 lowage nurses scored(129.16±15.97)points for their sense of occupational benefit.According to the standard for occupational benefit scores,the score results are at the middle and upper level;the scores of relatives and friends in all dimensions are the lowest,followed by nurses and patients The relationship score;the comparison of the professional benefit sense of the junior nurses in different departments,different educational backgrounds,and establishment or not,the difference was statistically significant (P＜0.05).Conclusion The sense of professional gain of junior nurses is above the average.Furthermore,the data showed that education background,establishment and department are the main influencing factors.
		2020 Vol. 27 (34): 189-191 [Abstract] ( 23 ) HTML (1 KB) PDF (0 KB) ( 10 )

	192	Blood-borne occupational exposure and risk factors of nursing staff
		HU Tao
		Objective To investigate the risk factors of blood-borne occupational exposure of nursing staff in a hospital to provide a basis for the development of effective prevention and control measures.Methods A retrospective analysis on the data of 103 nurses who had blood-borne occupational exposure from January 2018 to September 2019 in Ganzhou People′s Hospital was conducted.The risk factors of blood-borne occupational exposure by investigating the professional title,location,exposure method,medical activities and sources of exposure during the exposure were analyzed.Results Among the nursing staff who had occupational exposure to blood,most of them had primary or lower professional titles,accounting for 58.25%.With regards to the place of occurrence,78 cases(75.73%)in the ward,8 cases(7.77%) in the decontamination area of the disinfection supply center,6 cases (5.83%) in outpatient infusion,9 cases(8.74%) in the operating room,and 2 cases (1.94%) in other areas.On type of exposure,92 cases (89.32%) with sharp injuries,7 cases(6.80%)with mucosal contact,3 cases(2.91%)damaged skin,and 1 cases(0.97%)with complete skin.On medical activities during exposure,9 cases (8.74%)occurred when handling instruments,16 cases (15.53%)occurred when injections,38 cases (36.89%) occurred when handling medical waste,7 cases (6.80%) occurred when blood collection,13 cases (12.62%) occurred when needle removal,7 cases (6.80%) occurred when surgery,13 cases (12.62%) occurred in others.When talking about the source of exposure,8 cases(7.77%)with syphilis positive,39 cases(37.86%)with HBsAg positive,1 cases(0.97%)with anti-HCV positive,17 cases(16.50%)with unknown source of exposure,and 38 cases(36.89%)with negative source of exposure.Univariate analysis results showed that the difference between occupational exposure and occupational exposure without occupational exposure,education level,working years,frequency of occupational protection education,and the degree of importance attached to occupational protection by hospitals was statistically significant (P＜0.05).Multivariate analysis results showed that the educational level (β=-0.447,OR=0.855,95%CI=0.410-0.917),the frequency of occupational protection education (β=-0.426,OR=0.768,95%CI=0.346～0.836),and the degree of importance attached to occupational protection by the hospital (β=-0.377,OR=0.548,95%CI=0.517-0.724) were the protective factor for occupational exposure(P＜0.05).Conclusion Nurses and junior nursing staff are the high-risk groups of occupational exposure.It is necessary to optimize the hospital occupational exposure reporting process,strengthen the medical personnel protection training,establish occupational exposure monitoring system and take correct treatment and intervention after exposure.Care should be taken for nursing staff of the blood-borne occupational exposure risk management in order to reduce is incidence.
		2020 Vol. 27 (34): 192-194转198 [Abstract] ( 23 ) HTML (1 KB) PDF (0 KB) ( 13 )

	195	Investigation and analysis of the use of proton pump inhibitors for injection in 200 inpatients in Traditional Chinese Medicine Hospital of Ningde City
		WU Zhong-yu；LIU Zhao-yun；CHEN Xuan
		Objective To investigated the use of proton pump inhibitors (PPI) by inpatients in Traditional Chinese Medicine Hospital of Ningde,and analyze City the irrational use of drugs.Methods A total of 200 cases of inpatients were treated with PPI for injection in Traditional Chinese Medicine Hospital of Ningde City from August 2018 to August 2019 were selected,the departments,PPI dosage,treatment course,solvent selection and other information were statisticsed and analyzed.Results Among the 200 patients,39.00% of the patients were used the PPI for Esomeprazole,and 26.50% of the patients used Lansoprazole.The department with the highest usage rate of PPI for injection is the spleen and stomach department,followed by the emergency department.The rate of irrational use of PPI for injection in Traditional Chinese Medicine Hospital of Ningde City was 13.00%,and the common irrational situation was that the medication indication was not clear.Conclusion The PPI for injection in hospitals in Traditional Chinese Medicine Hospital of Ningde City is mainly Esomeprazole and Lansoprazole.The drug use rate of spleen and stomach disease is high,and there is still irrational drug use.It is necessary to further strengthen the management of standardized drugs.
		2020 Vol. 27 (34): 195-198 [Abstract] ( 31 ) HTML (1 KB) PDF (0 KB) ( 13 )

	199	Application of health self-management in patients with diabetic foot
		ZHOU Hua-rong
		Objective To investigate the application effect of health self-management in patients with diabetic foot.Methods The clinical data of 60 patients with diabetic foot admitted to Fuzhou First People′s Hospital from April 2013 to November 2019 were retrospectively analyzed.According to different intervention methods,they were divided into the control group and the observation group,30 cases in each group.The control group was given routine nursing,and the observation group was intervened by health self-management.The self-efficacy (diabetes self-efficacy scale[DSES]) and foot skin condition (including infection,chapping,dryness and injury) were compared between the two groups before and after intervention.Results After intervention,the scores of DSES in the two groups were higher than those before intervention,the differences were statistically significant (P＜0.05).The scores of DSES after intervention in the observation group were higher than those in the control group,the differences were statistically significant (P＜0.05).The incidence of adverse events of foot skin in the observation group was lower than that in the control group,the difference was statistically significant (P＜0.05).Conclusion Health self-management in patients with diabetic foot has significant effect,it can increase self-efficacy and reduce the incidence of adverse events of skin.
		2020 Vol. 27 (34): 199-201转205 [Abstract] ( 26 ) HTML (1 KB) PDF (0 KB) ( 12 )

	202	Effect of personalized health education combined with WeChat platform in the rehabilitation of patients with schizophrenia
		LI Yu-mei； LIU Fu-haizhen；ZHONG Guo-feng
		Objective To explore the effect of personalized health education combined with WeChat platform in the rehabilitation of patients with schizophrenia.Methods A total of 92 schizophrenic patients in the Third People′s Hospital of Maoming City from June 2018 to June 2019 were selected as the research objects,and they were divided into the observation group (46 cases) and the control group (46 cases) according to random number table method.Positive and negative symptom scales (PANSS),brief psychiatric rating scale(BPRS),ability of daily living(ADL)scale and total treatment compliance were compared between the two groups before intervention,3 months after intervention and 6 months after intervention.Results There were no statistically significant differences in the scores of PANSS,BPRS and ADL between the two groups before intervention (P＞0.05).At 3 months after intervention and 6 months after intervention,the sores of PANSS,BPRS and ADL in the observation group were lower than those in the control group,and the differences were statistically significant (P＜0.05).There was no statistically significant difference in the treatment compliance between the two groups before intervention (P＞0.05).At 3 months after intervention and 6 months after intervention,the total treatment compliance of the observation group were higher than those of the control group,and the differences were statistically significant (P＜0.05).Conclusion The personalized health education combined with WeChat platform can improve the mental symptoms of patients with schizophrenia,improve their daily living ability,social function and rehabilitation effect.
		2020 Vol. 27 (34): 202-205 [Abstract] ( 21 ) HTML (1 KB) PDF (0 KB) ( 15 )

	206	A case of P53-positive Waldenstrm macroglobulinemia
	m macroglobulinemia[J]. 中国当代医药, 2020,27(34): 206-209')" href="#">	HU Mi-mi；SONG Kui
		Waldenstrm macroglobulinemia (WM) is a lymphoplasmacytic lymphoma (LPL) with the secretion of monoclonal immunoglobulin M (IgM),accounting for 90% to 95% of the total LPL,which is a rare inert B-cell lymphoma.The incidence of this disease is low and the clinical manifestations are highly heterogeneous,which can easily lead to underdiagnosis and misdiagnosis.More than 90% of WM patients have been confirmed to have MYD88L265P site mutation,but MYD88L265P-negative WM patients are rarely reported.P53 is the most common mutated gene associated with human tumors,and P53 gene abnormality is an important factor leading to B-cell lymphoma,it is more common in diffuse large B-cell lymphoma and follicular lymphoma,but it is relatively rare in the occurrence and development of LPL/WM.This paper reports a case of P53-positive MYD88-negative WM,and reviews the literature to improve the understanding of the disease.
		2020 Vol. 27 (34): 206-209 [Abstract] ( 19 ) HTML (1 KB) PDF (0 KB) ( 8 )

	210	Three cases report of diagnosis and treatment of elderly patients with acute calculous cholecystitis during the corona virus disease 2019 epidemic
		ZHANG Chong ；ZHANG Zong-ming ； ZHAO Yue； DENG Hai ；LIU Zhuo； LIU Li-min； ZHU Ming-wen； WAN Bai-jiang
		Since the outbreak of coronavirus disease 2019 (COVID-19) for two months,the fight against epidemic situation has been taken as the most important work in hospitals of all-levels in China.Because of the requirements of epidemic prevention and control,general surgery focuses on emergency operation.It is a severe challenge to how effectively prevent nosocomial infection and avoid the occurrence of clustered epidemic events,and actively carry out emergency surgical treatment for critical patients right now.Based on the experience of diagnosis and treatment of acute calculous cholecystitis (ACC) in three elderly patients in Beijing Electric Power Hospital,State Grid Corporation during the severe period of COVID-19 epidemic from February 27 to 29,2020,this paper further discusses the full process of epidemic protection,the necessity and selection of surgical procedures for elderly patients with ACC,so as to provide reference for timely surgical treatment and effective epidemic protection of elderly patients in general surgery during the COVID-19 epidemic.
		2020 Vol. 27 (34): 210-213 [Abstract] ( 22 ) HTML (1 KB) PDF (0 KB) ( 10 )

	214	Hepatitis B cirrhosis complicated with influenza A and pulmonary aspergillus infection: a case report and literature review
		LI Fan； CHENG Jin-ying； LIU Xian-xian ；DING Guo-feng
		Patients with chronic hepatitis B developing to an irreversible stage can induce liver cirrhosis.Hepatitis B cirrhosis is the most common chronic liver disease,which is easily complicated by bacterial and fungal infections.Aspergillus is widely distributed in the external environment.It is an opportunistic pathogen,which can cause severe pneumonia with respiratory failure,and often occurs in patients with underlying diseases.Patients with hepatitis B cirrhosis complicated with invasive fungal infection have poor tolerance,difficult drug treatment,and significantly increased mortality.Therefore,the etiological examination should be improved as soon as possible,and antifungal therapy also should be started to improve the prognosis.This paper reports one case of a patient with hepatitis B cirrhosis and diabetes,infected with influenza A,complicated by pulmonary bacterial,aspergillus infections and recurrent gastrointestinal hemorrhage,then recovered after active comprehensive treatment,in order to improve clinicians′ understanding of infection in patients with end-stage liver diseases and avoid misdiagnosis and mistreatment.
		2020 Vol. 27 (34): 214-217 [Abstract] ( 26 ) HTML (1 KB) PDF (0 KB) ( 12 )

	218	Tracing and thinking of an adverse event of a case of urethral retention in the urinary duct stump
		ZHANG Li-jun ；HE Bin
		When the patients have the behavior of self-extubation,the ability of the nurses to deal with the emergency is particularly important.After the occurrence of adverse events,nurses,as the second victims,are given good guidance by managers to help them grow.By tracking the nursing adverse events caused by urinary catheter retention in urethra caused by delirium in one ICU patient and improper emergency management by nurses,the root cause of the incident was analyzed,and targeted improvement measures were formulated to relieve the pressure of nurses,promote the growth of nurses,and ensure the safety of patients.
		2020 Vol. 27 (34): 218-220 [Abstract] ( 20 ) HTML (1 KB) PDF (0 KB) ( 9 )

	221	Post-transplant lymphoproliferative disorders following renal transplantation：a case report and literatures review
		LI Ying； LIU Hang； HAN Meng-hu； WEI Shu-run； ZHANG Peng； BAI Bao-liang； WANG Qian；CHANG Yi-ge
		Lymphoproliferative disorders are a serious complication after solid organ or hematopoietic cell transplantation.It has low morbidity,versatile clinical manifestations and bad prognosis.At present,the understanding of this disease is still relatively limited,and there are also fewer such reports.This article reports a case of lymphoproliferative disorders after kidney transplantation and consults related literature to discuss the classification,clinical manifestations,treatment and prognosis of lymphoproliferative disorders after kidney transplantation.Through this case,it is recommended that nephrologists and urologist should pay attention to lymphoproliferative disorders after kidney transplantation and make a effective therapy.
		2020 Vol. 27 (34): 221-224 [Abstract] ( 24 ) HTML (1 KB) PDF (0 KB) ( 11 )

	225	Application of structured diabetes education program in patients with initial insulin treatment of type 2 diabetes
		ZHONG Mei-lan；WANG Chun-xia
		Objective To explore the application of structured diabetes education program (PEP) in the initial treatment of type 2 diabetes with insulin.Methods From January 2018 to January 2019,100 cases of patients with type 2 diabetes in the Fourth Affiliated Hospital of Nanchang University were selected as the research objects,according to the random number table method,they were divided into PEP group (50 cases) and the non PEP group (50 cases).PEP group specified by regular guidance patients nursing regularity and traditional nursing mode,the non PEP group adopted the traditional nursing method,the survey data were compared in two groups in self-care rating scale (ECCA) and quality of life scale (MLHFQ) scores.Results The scores of ECCA and MLHFQ in the PEP group were higher than those in the non-PEP group,and the differences were statistically significant (P＜0.05).Three months after nursing,the ECCA level of PEP group was higher than that of non-PEP group,and the difference was statistically significant (P＜0.05).The MLHFQ score of PEP group was higher than that of non PEP group 3 months after nursing,and the difference was statistically significant （P＜0.05）.The total satisfaction of PEP t group was 90%,and that of non PEP group was 40%.The total satisfaction of patients in PEP group was higher than that of non PEP group,the difference was statistically significant (P＜0.05).Conclusion The nursing effect of PEP program in diabetic patients with initial insulin treatment is significant,which can improve their self-care ability,improve their quality of life,and reduce the number of rehospitalizations.
		2020 Vol. 27 (34): 225-228 [Abstract] ( 26 ) HTML (1 KB) PDF (0 KB) ( 11 )

	229	Effect of situational nursing on daily life ability,condition improvement and self-nursing ability of patients with bipolar disorder
		WANG Qun-ying； WANG Jing； JIANG Dong-hua； XIA Zhi-min
		Objective To study the effect of situational simulation nursing on the daily life ability,the improvement degree of the condition and the self-care ability of patients with bipolar disorder.Methods The clinical data of 62 patients with bipolar affective disorder who were treated in Jiujiang Fifth People′s Hospital,Jiangxi Province from December 2018 to September 2019 were retrospectively analyzed.They were divided into control group and observation group according to different intervention methods,31 cases in each group.The control group was given routine treatment,and observation group was given situational simulation nursing based on control group.Both groups were continuously nursing for 3 weeks.The daily living ability,condition improvement and self-care ability of the two groups of patients before intervention and after 3 weeks of intervention were compared.Results The scores of activities of daily living (ADL)before intervention between the two groups,there was no statistically significant difference (P＞0.05);the ADL scores of the two groups after intervention for 3 weeks were lower than those before intervention,and the observation group was lower than the control group,the differences were statistically significant (P＜0.05).Nurses′ observation scale for inpatient evaluation (NOSIE) score between the two groups before the intervention,the difference was not statistically significant (P＞0.05);the NOSIE scores of the two groups after intervention for 3 weeks were higher than those before intervention,and the observation group was higher than the control group,the differences were statistically significant (P＜0.05).The scores of the exercise of self-care agency scale (ESCA) before intervention between the two groups,there was no statistically significant difference (P＞0.05);the ESCA scores of the two groups after intervention for 3 weeks were higher than those before intervention,and the observation group was higher than the control group,the differences were statistically significant (P＜0.05).Conclusion The use of situational simulated nursing intervention for patients with bipolar disorder can significantly improve the patient′s daily life ability,promote the improvement of the condition and enhance self-care ability,which is conducive to the patient′s prognosis and is worthy of popularization and use.
		2020 Vol. 27 (34): 229-231 [Abstract] ( 29 ) HTML (1 KB) PDF (0 KB) ( 15 )

	232	Application effect of psychological nursing in nursing of elderly patients with chronic obstructive pulmonary disease
		LI Jue； ZHANG Xiao-hua； TAO Qi ；ZENG Hui-ying
		Objective To observe the application effect of psychological nursing in elderly patients with chronic obstructive pulmonary disease (COPD).Methods A total of 46 elderly patients with COPD admitted to the Second People′s Hospital of Pingxiang City Jiangxi Province from August 2019 to January 2020 as research objects,they were divided into reference group (23 cases) and observation group (23 cases) according to the random number table method.The patients in the reference group adopted routine nursing,and the patients in the observation group adopted psychological nursing on the basis of the reference group.The depression score,anxiety score,improvement of lung function and treatment compliance were compared between the two groups.Results The observation group′s forced expiratory volume in 1 second (FEV1),forced vital capacity (FVC) and the ratio of FEV1/FVC were higher than those in the reference group,the differences were statistically significant (P＜0.05).After treatment,the observation group′s Zung depression self-rating scale (SDS) and Zung anxiety self-rating scale (SAS) score were lower than those of the reference group,the differences were statistically significant (P＜0.05).The treatment total compliance of the observation group was higher than that of the reference group,the difference was statistically significant (P＜0.05).Conclusion Psychological nursing is helpful to relieve the negative psychology of elderly patients with COPD and improve lung function,and has good application value.
		2020 Vol. 27 (34): 232-234 [Abstract] ( 30 ) HTML (1 KB) PDF (0 KB) ( 10 )

	235	Influence of evidence-based nursing mode on the bad mood and treatment compliance of patients with coronary heart disease and angina pectoris
		SHANGGUAN Qin-e ；YANG Shu-jiao； HU Si-ju
		Objective To explore the influence of evidence-based nursing mode on the bad mood and treatment compliance of patients with coronary heart disease and angina pectoris.Methods From May 2017 to December 2019,48 patients with angina pectoris of coronary heart disease treated in Dongxiang People′s Hospital of Fuzhou City were selected as the research objects.According to the method of random comprehensive balance,they were divided into group A (n=24) and group B (n=24).Group A adopted the routine nursing mode and group B implemented the evidencebased nursing mode.The scores of self-rating anxiety scale (SAS) and self-rating depression scale (SDS),quality of life(SF-36) and treatment compliance were compared between the two groups.Results The scores of SAS and SDS in group B were lower than those in group A;the scores of SF-36 in group B were higher than those in group A;the score of treatment compliance in group B was higher than that in group A,with statistical differences (P＜0.05).Conclusion The implementation of evidence-based nursing mode in patients with coronary heart disease and angina pectoris has significantly improved their bad mood,their quality of life and treatment compliance.
		2020 Vol. 27 (34): 235-237 [Abstract] ( 29 ) HTML (1 KB) PDF (0 KB) ( 12 )

	238	Effect of fasting and drinking prohibition intervention on fasting blood glucose，fasting insulin，insulin resistance index and adverse reactions of operating room nurses based on the concept of accelerated rehabilitation surgery
		TANG Zhi-hong； WANG Zhen； ZHANG Yan-qin； ZENG Yang
		Objective To investigate the effect of fasting and drinking prohibition on fasting blood glucose (FPG),fasting insulin (FINS),insulin resistance index (HOMA-IR) and adverse reactions in patients undergoing accelerated rehabilitation surgery (FTS).Methods A total of 100 consecutive operation patients in 908 Hospital,Joint logistics Support Force of PLA from December 2018 to December 2019 were selected.They were divided into control group and observation group,50 cases in each group.The control group received routine preoperative fasting and drinking intervention,while the observation group received fasting and drinking intervention in the operating room based on the concept of FTS.The fasting and drinking time,changes of FPG,FINS,HOMA-IR and adverse reactions before and after operation were compared between the two groups.Results The preoperative fasting time and abstinence time in the observation group were shorter than those in the control group,the differences were statistically significant (P＜0.05).There were no statistically significant difference in FPG,FINS and HOMA-IR between the two groups before operation (P＞0.05).Compared with preoperation,1 d after operation,FPG,FINS and HOMA-IR in the two groups were increased,followed by a progressive decrease (P＜0.05).FPG,FINS and HOMA-IR in the observation group were all lower than those in the control group at 1 and 3 d after operation,the differences were statistically significant (P＜0.05).The incidence rates of thirst and hunger in the observation group were lower than those in the control group,the differences were statistically significant(P＜0.05).Conclusion The intervention of fasting and drinking in the operating room based on the concept of FTS can shorten the time of fasting and drinking before surgery,improve glucose metabolism and insulin resistance,reduce adverse reactions,and achieve satisfactory clinical effects.
		2020 Vol. 27 (34): 238-240 [Abstract] ( 24 ) HTML (1 KB) PDF (0 KB) ( 16 )

	241	Application of cluster nursing model combined with neonatal touching in neonatal hyperbilirubinemia
		LIU Li； ZHENG Fang-ming； CHEN Hui-juan ；WU Gui-feng ；XU Xiao-ding
		Objective To study the clinical value of hyperbilirubinemia neonate receiving intensive care combined with neonatal touch mode intervention.Methods From October 2019 to April 2020,60 neonates with hyperbilirubinemia treated in Yingtan People′s Hospital,Jiangxi Province were selected and divided into control group (n=30) and observation group (n=30) by the random list method.The control group received routine neonatal nursing,in the observation group,on the basis of routine neonatal nursing,the cluster nursing combined with neonatal touch mode intervention was added.The control effect of the two groups,jaundice index and bilirubin level before and after nursing intervention,the time of complete disappearance of jaundice,the time of recovery of bilirubin level examination results,the total time of hospitalization treatment,adverse reactions,parents′ satisfaction with nursing services were compared.Results The total effective rate of disease control in the observation group was 93.3%,higher than 70.0% in the control group;the jaundice index and bilirubin level in the observation group were lower than those in the control group;the time of complete disappearance of jaundice,the time of recovery of bilirubin level and the total time of hospitalization were shorter than those in the control group;the total incidence of adverse reactions in the observation group was 3.3% (1/30),lower than 20.0% (6/30) in the control group;parents′response to the total satisfaction of nursing service was 96.7%,higher than 80.0% of the control group.There were statistical significances (P＜0.05).Conclusion The intervention of nursing combined with touch mode can improve jaundice index,decrease bilirubin level in a short period of time,reduce the occurrence of adverse reactions,shorten the time of hospitalization,and improve the treatment effect of the disease and the satisfaction of the family.
		2020 Vol. 27 (34): 241-243 [Abstract] ( 30 ) HTML (1 KB) PDF (0 KB) ( 8 )

	244	Study on the effect of knowledge，attitude and practice health education model on maternal and infant outcomes and infant care ability of primiparas
		XU Han-xiu
		Objective To explore the application effect of knowledge,attitude and practice (KAP) health education model in primiparas.Methods A total of 60 primiparas from July 2019 to July 2020 in Affiliated Hospital of Jiangxi College of Traditional Chinese Medicine were selected and divided into control group and observation group according to random number table method,30 cases in each group.The control group was given health education,and the observation group was given KAP health education mode.The incidence of adverse maternal and infant outcomes such as cesarean section were observed and compared.The amount of postpartum hemorrhage,the duration of total labor,and the ability of neonatal care before and after intervention were recorded.Results The total incidence of adverse maternal and infant outcomes in the observation group was 3.33%,which was lower than 26.67% of the control group,the difference was statistically significant (P＜0.05).The postpartum hemorrhage volume of the observation group was (285.22±20.43) mL,which was less than that of the control group of (300.29±20.54) mL;the total labor process time was(225.89±18.57) min,shorter than that of the control group of (258.36±18.74) min,with statistical differences (P＜0.05).There was no significant difference in the score of neonatal care ability between the two groups before intervention (P＞0.05).After intervention,the scores of knowledge ([60.18±6.57]points),skills ([38.19±5.64]points) and attitude([16.94±2.75]points) in the observation group were higher than those in the control group of (43.97±6.24),(26.35±5.22),(11.58±2.56) points in the control group,with statistical differences (P＜0.05).Conclusion The application of KAP health education model in primiparas can protect the health of mothers and infants,improve the outcomes of mothers and infants,and promote the improvement of neonatal care ability.
		2020 Vol. 27 (34): 244-246转250 [Abstract] ( 26 ) HTML (1 KB) PDF (0 KB) ( 11 )

	247	Application effect of high quality nursing service in schizophrenia patients
		XIE Xiao-hu；CAO Zhi
		Objective To study the application effect of high quality nursing service in schizophrenic nursing and analyze its value.Methods From January 2019 to January 2020,60 patients who came to Mental Hospital of Guangzhou Civil Affairs Bureau for treatment of schizophrenia were selected.According to the order of admission,patients were divided into experimental group and control group,30 cases in each group.The patients in the experimental group received high-quality nursing services,while the patients in the control group received routine nursing services.The quality of life scores,incidence of adverse events,social deficiency screening scale (SDSS) scores at different times of admission,and treatment dependence of the two groups were compared.Results After nursing,the quality of life scores of patients in the experimental group were higher than those in the control group,the differences were statistically significant (P＜0.05);the total incidence of adverse events in the experimental group was lower than that in the control group,the difference was statistically significant (P＜0.05).8 weeks after admission,the SDSS score of the experimental group was lower than that of the control group,the difference was statistically significant (P＜0.05).The total dependence rate of the experimental group was higher than that of the control group (P＜0.05).Conclusion The high quality nursing service in schizophrenia nursing can get good application effect,not only can improve the quality of life of patients,but also can reduce the occurrence of adverse events,the dependence of patients is also high,and the social function defects have been well made up,so it can be widely used in clinical.
		2020 Vol. 27 (34): 247-250 [Abstract] ( 20 ) HTML (1 KB) PDF (0 KB) ( 9 )

	251	Application of emergency intensive care in patients with acute myocardial infarction in intensive care unit of cardiology department
		LU Jia-li
		Objective To explore the clinical application value of emergency intensive care with acute myocardial infarction (AMI) in intensive care unit of cardiology department.Methods A total of 80 cases with AMI in the intensive care unit of cardiology department the Second Affiliated Hospital of Shenyang Medical College from February 2019 to April 2020 were selected and divided into two group according to the method of random number table,40 cases in each group.The control group was received routine nursing,the observation group was received emergency intensive nursing.Then the changes of cardiac troponin I (Tn-I) level before and after the intervention were compared between the two groups.The incidence of complications during hospitalization was compared between the two groups.The disease selfmanagement ability and life quality after intervention were compared between the two groups.Results After the intervention,the level of Tn-I in both groups was lower than that before intervention,the difference was statistically significant (P＜0.05),the level of Tn-I in the observation group was lower than that of the control group,the difference was statistically significant (P＜0.05).The total proportion of heart failure,ventricular aneurysm and life-threatening arrhythmia in the observation group during hospitalization was lower than that of the control group,the difference was statistically significant (P＜0.05).The score of disease self-management ability in the observation group was higher than that of the control group,the difference was statistically significant (P＜0.05).The score of life quality was higher than that of the control group,the difference was statistically significant (P＜0.05).Conclusion Emergency intensive care for patients in intensive care unit of cardiology department can effectively reduce the cardiac function damage of patients,reduce the incidence of complications,improve the subjective cognition of patients to diseases,and thus improve the prognosis.
		2020 Vol. 27 (34): 251-252 [Abstract] ( 21 ) HTML (1 KB) PDF (0 KB) ( 9 )

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