ABCB1基因rs2032582多态性与乳腺手术后恶心呕吐的关系

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Abstract Objective To explore the relationship between ABCB1 rs2032582 gene polymorphism and postoperative nausea and vomiting undergoing breast surgery.Methods From December 2016 to January 2019,240 female patients who received breast surgery with general anesthesia in Fujian Medical University Union Hospital were selected as the subjects.Age,body mass index (BMI),history of motion sickness,history of postoperative nausea and vomiting,duration of anesthesia and occurrence of postoperative nausea and postoperative vomiting in early and later period (within first 6 hours and within 6 to 24 hours after surgery,respectively) were recorded.Improved multiple ligase detection reaction(iMLDR) was used for genotyping and relationship between ABCB1 rs2032582 gene polymorphism and postoperative nausea and vomiting was analyzed with logistic regression model.Results Patients carrying CT genotype had a 4.674 times greater risk of postoperative nausea than those carrying CC genotype in later period,CT genotype was a risk factor for postoperative nausea in later period (β=1.542,OR=4.674,95%CI=1.138-19.202,P＜0.05).Conclusion ABCB1 rs2032582 gene polymorphism had an association with postoperative nausea in later period,which may be one of important factors affecting female genetic susceptibility to postoperative nausea and vomiting undergoing breast surgery with general anesthesia.

Key words： Postoperative nasuea and vomiting Breast surgery Gene polymorphism ABCB1 gene rs2032582

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SU Jian-sheng. Relationship between ABCB1 rs2032582 gene polymorphism and postoperative nausea and vomiting undergoing breast surgery[J]. 中国当代医药, 2020, 27(34): 4-7.

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https://www.dangdaiyiyao.com/EN/ OR https://www.dangdaiyiyao.com/EN/Y2020/V27/I34/4

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