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| Squamous cell carcinoma antigen,neuron-specific enolase,carcinoembryonic antigen levels in patients with esophageal cancer and their relationship with clinicopathological factors |
| ZHANG Cai-tian1 XIE Er-fu2 |
1.Department of Laboratory,Yizheng People′s Hospital
2.Department of Laboratory,Jiangsu Provincial People′s Hospital |
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Abstract Objective To explore the relationship between squamous cell carcinoma antigen (SCC),neuron-specific enolase (NSE),carcinoembryonic antigen (CEA) levels and clinicopathological factors in patients with esophageal cancer.Methods A total of 82 patients with esophageal cancer admitted to Yizheng People′s Hospital from May 2017 to May 2020 were selected as the observation group,and 90 healthy people who received physical examination during the same period were selected as the control group.The serum SCC,NSE and CEA levels were compared between the two groups.The serum SCC,NSE and CEA levels in patients with esophageal cancer with different clinicopathological characteristics were investigated,the factors affecting the serum SCC,NSE and CEA levels were analyzed.Results Serum SCC,NSE and CEA levels in the observation group were higher than those in the control group,and the differences were statistically significant (P＜0.05).There were no significant differences in serum SCC,NSE and CEA levels in patients with esophageal cancer of different genders and ages (P＞0.05).The patients with lymph node metastasis,high degree of differentiation,and TNM stages Ⅲand Ⅳhad higher serum SCC,NSE and CEA levels,the differences were statistically significant (P＜0.05).The levels of serum SCC,NSE and CEA were used as dependent variables,and lymph node metastasis,differentiation degree and TNM stage were used as independent variables for univariate linear regression analysis.The results showed that lymph node metastasis,degree of differentiation and TNM stage of tumor were the factors affecting the serum SCC,NSE and CEA levels in patients with esophageal cancer (P＜0.05).Conclusion SCC,NSE and CEA expression levels are higher in patients with esophageal cancer.Lymph node metastasis,degree of differentiation,and tumor TNM stage are factors that affect the serum levels of SCC,NSE and CEA in patients with esophageal cancer.
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| [1] |
华星，李从进，荆成宝.食管癌患者的SCC、CEA、CYFRA21-1水平及其临床意义研究[J].中国肿瘤外科杂志，2020，12（3）：233-236.
|
| [2] |
姚丽华，邹江，孙茹，等.食管癌组织端粒保护蛋白TPP1表达及临床意义[J].中华肿瘤防治杂志，2019，26（7）：463-467.
|
| [3] |
王超.食管癌放疗前后血清CEA、SCC 和CYFRA21-1 水平的变化[J].中国继续医学教育，2020，12（21）：114-116.
|
| [4] |
Mahmoudi M，Jamshidi AR，Amirzargar AA，et al.Association between Endoplasmic Re ticulum Aminopeptidase-1（ERAP-1）and Susceptibility to Ankylosing Spondylitis in Iran[J].Iran J Allergy Asthma Immunol，2016，11（4）：294-300.
|
| [5] |
王雨梦.血清SCC、CA19-9、CEA 联合检查对诊断食管癌的临床价值分析[J].罕少疾病杂志，2019，26（6）：55-57.
|
| [6] |
谭文，王娟，李钢.食管癌放疗前后血清肿瘤标志物CEA、SCC 和CYFRA21-1 水平的变化[J].心电图杂志（电子版），2019，8（4）：140-141.
|
| [7] |
张胜强，崔虎军，郭建宇，等.联合检测食管癌手术患者CTCs、CEA、Scc 和CA199 的临床意义[J].当代医学，2019，25（20）：118-119.
|
| [8] |
蓝聪，林万里，陈颖，等.术前MSCT 联合血清SCC、CA19-9、CEA 检查对诊断食管癌的临床价值分析[J].中国CT 和MRI杂志，2019，17（5）：90-92，封4.
|
| [9] |
韩玉秋，郑德文，杜振元.西妥昔单抗联合FP 方案治疗中晚期食管癌的疗效及对血清CEA、SCC 水平和生存质量的影响[J].现代肿瘤医学，2019，27（8）：1339-1344.
|
| [10] |
张国政，张金花.血清CEA、SCC 和CYFRA21-1 在食管癌放、化疗前后的变化[J].现代肿瘤医学，2017，25（22）：3628-3631.
|
| [11] |
Howman RA，Charles AK，Jacques A，et al.Inflammatory and haematological markers in the maternal，umbilical cord and infant circulation in histological chorioamnionitis[J].PLoS One，2012，7（12）：51 836.
|
| [12] |
刘叶果，鲍亮亮.雷替曲塞联合顺铂及放疗治疗中晚期食管癌的疗效及对患者血清SCC、CEA 的影响[J].实用癌症杂志，2018，33（5）：848-851.
|
| [13] |
李叶枚，马春成.五膈宽中散联合紫杉醇-顺铂对不同体质量指数晚期食管癌患者疗效与预后的影响[J].世界中西医结合杂志，2020，15（5）：900-903.
|
| [14] |
申景涛，施鸣，辛小燕，等.食管癌放疗前后血清肿瘤标志物CEA、SCC 和CYFRA21-1 水平的变化分析[J].标记免疫分析与临床，2016，23（11）：1251-1253，1263.
|
| [15] |
张静.多项肿瘤标志物联合检测在食管癌诊断中的应用价值[J].中国卫生检验杂志，2020，30（3）：313-315.
|
|
|
|
