|
|
|
| Effect of Mometasone Furoate Nasal Spray combined with Montelukast Sodium Chewable Tablets in the treatment of allergic rhinitis |
| KUAI Ye-bin ZHU Li-ping SHAO Bing-huan |
| Department of Otorhinolaryngology,Changzhou Maternal and Child Health Hospital |
|
|
|
|
Abstract Objective To explore the effect of nasal hormone drugs combined with leukotriene receptor antagonists in the treatment of allergic rhinitis (AR) and the influence on patients′ nasal secretion eosinophils (EOS),serum immunoglobulin E (IgE),soluble ST2 (sST2) and related cytokines.Methods A total of 120 AR patients from January 2016 to May 2018 admitted to Changzhou Maternal and Child Health Hospital were selected as the research objects and divided into the combined group and the control group by the randomized block design,with 60 cases in each group.Both groups were given Mometasone Furoate Nasal Spray for treatment,the combined group was treated with Montelukast Sodium Chewable Tablets at the same time.The scores of nasal congestion symptom,sneezing symptom,nasal itching symptom,runny nose symptom,nasal EOS positive rate,serum IgE,interleukin-6 (IL-6),and interleukin-8 (IL-8) before and after treatment and clinical efficacy were compared between the two groups.Results After 4 weeks of treatment,the scores of nasal congestion symptom,sneezing symptom,nasal itching symptom and runny nose symptom in the combined group were lower than those in the control group,and the differences were statistically significant(P＜0.05).After 4 weeks of treatment,the nasal EOS positive rate,serum IgE,IL-6 and IL-8 levels in the combined group were lower than those in the control gr oup,and the differences were statistically significant (P＜0.05).The clinical efficacy of the combined group was better than that of the control group,and the di fference was statistically significant(P＜0.05).Conclusion The effect of Mometasone Furoate Nasal Spray combined with Mont elukast Sodium Chewable Tablets is better than that of mometasone furoate nasal spray in the treatment of AR patients.
|
|
|
|
|
|
| [8] |
邢志敏，王梓敬，李世昌.重视预防治疗在变应性鼻炎治疗体系中的作用[J].临床耳鼻咽喉头颈外科杂志，2017，31（1）：6-8.
|
| [9] |
李丽莎，关凯，崔乐，等.单药加倍或多药联合治疗变应性鼻炎效果比较[J].临床耳鼻咽喉头颈外科杂志，2018，32（1）：27-32.
|
| [10] |
蒋昱，黄传君，李泽，等.白三烯受体拮抗剂通过Wnt/βcatenin 信号通路影响哮喘小鼠气道重塑机制的研究[J].中国医科大学学报，2018，47（3）：226-230.
|
| [11] |
贾明辉，陈晓云，张悦，等.鼻用激素联合氯雷他定或孟鲁司特钠治疗变应性鼻炎的疗效分析[J].临床耳鼻咽喉头颈外科杂志，2017，52（5）：369-373.
|
| [1] |
中华耳鼻咽喉头颈外科杂志编辑委员会鼻科组，中华医学会耳鼻咽喉头颈外科学分会鼻科学组.变应性鼻炎诊断和治疗指南（2015年，天津）[J].中华耳鼻咽喉头颈外科杂志，2016，51（1）：6-24.
|
| [2] |
程雷.变应性鼻炎防治应关注的问题[J].临床耳鼻咽喉头颈外科杂志，2017，31（1）：1-2.
|
| [3] |
邱前辉.变应性鼻炎免疫治疗的现状和未来[J].临床耳鼻咽喉头颈外科杂志，2017，31（1）：9-12.
|
| [4] |
中华耳鼻咽喉头颈外科杂志编辑委员会中华医学会.变应性鼻炎的诊治原则和推荐方案（2004年，兰州）[C].中华医学会.2009年全国鼻部感染与变态反应专题学术会议论文集.2009：37-39.
|
| [5] |
严景辉，王豪.舌下抗原特异性免疫治疗过敏性鼻炎的临床疗效评价[J].海南医学，2018，29（20）：2853-2855.
|
| [6] |
Numminen J.Allergic rhinitis[J].Pediatr Clin North Am，2017，28（4）：797.
|
| [7] |
沙骥超，孟粹达，修倩，等.变应性鼻炎治疗新策略[J].中华耳鼻咽喉头颈外科杂志，2016，51（2）：150-155.
|
| [12] |
莫丽慧，钟丽花.孟鲁司特联合布地奈德治疗支气管哮喘患儿的临床观察[J].中国药房，2017，28（14）：1981-1984.
|
| [13] |
Goh BS，IsmaiL MI，Husain S.Quality of life assessment inpatients with moderate to severe allergic rhinitis treated withmontelukast and /or intransal steroids：a randomized，double-blind，placeb-controlled study[J].J Laryngol Otol，2014，128（3）：242-248.
|
| [14] |
Cardona V，Luengo O，Labrador M.Immunotherapy in allergic rhinitis and lower airway outcomes[J].Allergy，2017，72（1）：35-42.
|
| [15] |
Bousquet J，Caimmi DP，Bedbrook A，et al.Pilot study of mobile phone technology in allergic rhinitis in European countries：the MASK-rhinitis study[J].Allergy，2017，72（6）：857-865.
|
| [16] |
李滨，黄守林，林婕.孟鲁司特钠对哮喘急性发作期患者肺功能及炎症因子的影响[J].中国医药导报，2014，11（7）：12-14.
|
| [17] |
陈素哲，赵涛，范伟，等.孟鲁司特钠联合舒利迭对毛细支气管炎再发喘息的预防及对Th1/Th2 的影响[J].重庆医学，2018，47（15）：2074-2076.
|
| [18] |
肖秋江，王麒铧.孟鲁司特钠片辅助治疗小儿咳嗽变异性哮喘的效果及其对TNF-α、IL-8、免疫功能的影响[J].中国医药科学，2018，8（22）：21-24，60.
|
| [19] |
罗经权.布地奈德联合孟鲁司特钠治疗小儿支气管哮喘的临床疗效观察[J].中国现代医生，2019，57（19）：65-67，71.
|
| [20] |
谭雪婷，林彩战，程金红.孟鲁司特钠片结合布地奈德福莫特罗粉治疗支气管哮喘的效果[J].当代医学，2020，26（16）：151-152.
|
|
|
|
