补肾祛风湿法对类风湿关节炎患者肠道微生态的影响研究

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Abstract Objective To investigate the influence of kidney nourishing and dampness disinhibiting therapy on the intestinal microecology of patients with rheumatoid arthritis (RA).Methods A total of 80 RA patients treated in Jiujiang First People′s Hospital from January 2017 to December 2018 were selected as the research objects,and they were divided into the control group and the observation group according to random number table method,40 cases in each group.The control group was treated with Methotrexate,and the observation group was treated with Wangbi Tablets,all patients were treated for 3 months.The efficacy,intestinal flora diversity and safety indicators (adverse drug reactions,blood routine,urine routine,liver and kidney function) of the two groups were compared.Results After 3 months of treatment,the total effective rate of the observation group was 97.50%,which was higher than 80.00% of the control group,and the difference was statistically significant (P＜0.05).After 3 months of treatment,the uniformity of the intestinal flora of the observation group was (0.99±0.06) E,and richness of the intestinal flora of the observation group was(22.68±3.08) S,which were higher than those of the control group ([0.90±0.05]E and [19.36±2.16]S),the differences were statistically significant (P＜0.05).The incidence of adverse reactions in the observation group was 2.50%,which was lower than 20.00% in the control group,and the difference was statistically significant (P＜0.05).Conclusion Kidney nourishing and dampness disinhibiting therapy in the treatment of RA can significantly improve the therapeutic effect,restore the patients′ intestinal micro-ecological diversity,has higher safety of use of drug,can promote the recovery of patients,and which is worthy of promotion.

Key words： Rheumatoid arthritis Kidney nourishing and dampness disinhibiting therapy Intestinal microecology

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	Articles by authors
	JI Sen-guo
	ZHANG Xu-ming
	WU Di
	LIU Ju

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JI Sen-guo,ZHANG Xu-ming,WU Di, et al. Study on the influence of kidney nourishing and dampness disinhibiting therapy on intestinal microecology of patients with rheumatoid arthritis[J]. 中国当代医药, 2020, 27(34): 171-174.

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https://www.dangdaiyiyao.com/EN/ OR https://www.dangdaiyiyao.com/EN/Y2020/V27/I34/171

[1]	魏志萍，洪芬芳，杨树龙.中药治疗类风湿关节炎的研究进展[J].中华中医药杂志，2017，32（12）：5477-5481.
[2]	郭立霞，黄照国，闫恒志，等.清热利湿通络方联合西药治疗类风湿关节炎湿热痹阻证疗效观察[J].西部中医药，2018，31（7）：83-86.
[3]	朱樱，胡赟霞.授权赋能理论的健康教育对类风湿关节炎患者自我效能及生活质量的影响[J].西部中医药，2019，32（5）：131-134.
[4]	邵莉.类风湿关节炎的早期诊断指标价值及临床治疗效果观察[J].中国当代医药，2016，23（27）：72-75.
[5]	毕丹艳，李芹，张虹，等.雷公藤多苷联合甲氨蝶呤治疗类风湿关节炎的临床疗效研究[J].中国临床药理学杂志，2016，32（10）：880-882.
[6]	何奕坤，杨光辉，郑玥琪，等.miRNAs 与类风湿关节炎炎症因子相关性及中药对其干预的研究进展[J].中国中西医结合杂志，2018，38（6）：759-762.
[7]	朱洁宜，吴鑫宇，周海纯，等.中医药治疗类风湿关节炎的研究进展[J].中医药信息，2015，32（1）：115-117.
[8]	中华医学会风湿病学分会.类风湿关节炎诊治指南[J].现代实用医学，2004，16（3）：184-188.
[9]	袁钰荔，尹玉月，范惠珍.DAS28-CRP 与DAS28-ESR 评分在类风湿关节炎中的比较[J].实用中西医结合临床，2018，18（11）：5-6，9.
[10]	方勇飞，刘晓飞.肠道菌群失调与类风湿关节炎发病及疾病进展的相关性[J].西部医学，2017，29（11）：1485-1487，1491.
[11]	Baas GH，Romero-Figueroa MDS，Montiel-Jarquín AJ，et al.Intestinal Dysbiosis and Rheumatoid Arthritis：A Link between Gut Microbiota and the Pathogenesis of Rheumatoid Arthritis[J].J Immunol Res，2017，2（4）：1-13.
[12]	魏慧，赵金霞，刘湘源.肠道菌群在类风湿关节炎发病中的作用研究进展[J].中华医学杂志，2018，98（21）：1723-1725.
[13]	刘维，王朝旭，吴沅皞.260例类风湿关节炎患者中医证型聚类分析[J].中医杂志，2016，57（6）：508-511.
[14]	闫学朋，黄传兵，付俊，等.类风湿关节炎中医辨证论治研究进展[J].吉林中医药，2017，37（8）：861-864.
[15]	何奕坤，杨光辉，胥晓芳，等.类风湿关节炎继发肺间质病变的中医药治疗进展[J].西部中医药，2018，31（3）：140-143.
[16]	吴廷换，周辉，陈兴恺.清宫正骨手法联合尪痹片治疗膝关节骨性关节炎疗效观察[J].中国中医骨伤科杂志，2017，25（1）：38-41.
[17]	陈璐，阎小萍，鄢泽然，等.尪痹片治疗膝骨性关节炎有效性及安全性的临床研究[J].中华中医药杂志，2018，33（8）：160-163.
[18]	刘益臻，马武开，何康，等.尪痹片对关节炎小鼠骨髓RhoA 和ROCK1 的影响[J].重庆医学，2017，46（22）：3125-3127.