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Quick Search     Adv Search 2022 Vol. 29, No. 9 Published: 2022-03-28   11 Regulatory effect of Ranunculus ternatus on liver function of pulmonary tuberculosis patients ZHANG LihuaWANG YuanchunGONG JingZHANG YuLIU Pingqing Objective To explore the value of Ranunculus ternatus on liver function of pulmonary tuberculosis patients.Methods A total of 80 cases who was diagnosed as tuberculosis in the tuberculosis ward in the Fifth People′s Hospital of Ganzhou City from August 2019 to August 2020 were used tetralogy (Isoniazid, Rifampicin, Pyrazinamide, Ethambutol) anti-tuberculosis drugs and divided into Observation group and control group according to random number table method, with 40 cases in each group. For liver function protection, the control group was given Dangfeiliganning Capsule, the observation group was given Ranunculus ternatus. Then the changes of liver function related indexes and liver fibrosis related indexes between the two groups were ompared, count the first time of abnormal liver function and the time of liver function recovery during treatment, the clinical effect of anti-tuberculosis treatment between the two groups were compared. Results The levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and total bilirubin (TBil) in the observation group were lower than those in the control group, the differences were statistically significant (P<0.05), and the levels of hyaluronic acid (HA) and procollagen Ⅲ(PC Ⅲ) in the related indexes of liver fibrosis in the observation group were lower than control group, the differences were statistically significant (P<0.05).The liver function in the observation group recovered earlier than control group, and the difference was statistically significant (P<0.05). During the follow-up period of half a year, the sputum bacteria conversion rate and chest film absorption improvement rate in the observation group were higher than control group, and the differences were statistically significant (P<0.05). Conclusion The use of Ranunculus ternatus to regulate the liver function of patients who have been treated with anti-tuberculosis drugs for a long time can effectively improve the liver function of patients and inhibit the formation of liver fibrosis and improve the clinical anti-tuberculosis treatment effect. 2022 Vol. 29 (9): 11-14 [Abstract] ( 32 ) HTML (1 KB)  PDF (539 KB)  ( 30 ) 15 Diagnostic value of tumor associated autoantibodies combined with tumor markers in the lung cancer JING Mengjun CHEN Wei Objective To explore the diagnostic value of serum 7 tumor associated autoantibodies (7-TAABS) and tumor markers in lung cancer. Methods A total of 149 patients with lung cancer admitted to the First Affiliated Hospital of Xi′an Jiao Tong University from December 2020 to July 2021 were selected as the lung cancer group, and 86 patients with benign lung disease were selected as the control group. The levels of p53, PGP9.5, SOX2, GAGE7,GBU4-5, MAGE-A1, CAGE antibodies and 3 tumor markers (squamous cell carcinoma [SCC], carcinoembryonic antigen[CEA]and cytokeratin 19 fragment [CYFRA21-1]) were compared between two groups, the diagnostic efficacy of 7-TAABs and tumor markers in lung cancer were analyzed. Results Serum levels of 3 tumor markers and p53, PGP9.5,SOX2, GAGE7, GBU4-5 and MAGE-A1 in 7-Taabs in lung cancer group were higher than those in control group, the differences were statistically significant (P<0.05). The positive rate of 7-TAABS combined with 3 tumor markers was higher than that of the control group, the difference was statistically significant (P<0.05). The sensitivity, accuracy and negative predictive value of 7-TAABS combined with 3 tumor markers were 83.22%, 79.15% and 71.26%, respectively.Conclusion The combined detection of 7-TAABs and traditional tumor markers can improve the diagnostic efficiency and provide basis for the diagnosis and screening of lung cancer. 2022 Vol. 29 (9): 15-18 [Abstract] ( 42 ) HTML (1 KB)  PDF (535 KB)  ( 41 ) 19 Analyse of health-related quality of life in patients with functional dyspepsia and its influencing factors CHEN Weihong;LI Yanhua;DAI Ning;ZHANG Lei;QI Shuchun;WANG Liming Objective To investigate the status of health-related quality of life (HRQoL) in patients with functional dyspepsia (FD) and analyze its influencing factors. Methods A total of 168 FD patients admitted to Beijing NO.6 Hospital from August 2018 to June 2019 were selected for a cross-sectional study. HRQoL of FD patients was analyzed using a brief health survey form (SF-36), and clinical, psychosocial, and demographic factors were investigated. Multiple linear regression analysis was used to determine the factors associated with decreased HRQoL in FD patients. Results In FD patients, HRQoL was impaired in all aspects except energy (VT). The total physical health assessment (PCS) score was(43.3±8.4) and the total mental health assessment (MCS) score was (46.8±10.0). Age increase, female, primary and secondary education, and severity of symptoms were the influencing factors of PCS damage (P＜0.05). Female sex, severity of symptoms, anxiety and depression were influencing factors of impaired MCS (P＜0.05). Conclusion The reduction of HRQoL in FD patients is affected by age, gender, severity of symptoms and other factors, which should be actively intervened to ensure the quality of life of FD patients. 2022 Vol. 29 (9): 19-22 [Abstract] ( 39 ) HTML (1 KB)  PDF (572 KB)  ( 12 ) 23 Effect of glucocorticoid assisted Azithromycin in children with Mycoplasma pneumoniae infected lobar pneumonia LI Xuejuan Objective To explore the application effect of glucocorticoid assisted Azithromycin in children with Mycoplasma pneumoniae infected lobar pneumonia. Methods A total of 80 children with mycoplasma-infected lobar pneumonia admitted to the Department of Pediatrics of Tongzhou District People′s Hospital of Nantong City from June 2019 to June 2021 were selected as the research objects. A random number table method was used to divide children into the experimental group and the control group, 40 cases in each group. Both groups were given basic treatment such as physical cooling or analgesia and fever, relieving asthma and resolving phlegm. The control group was given Azithromycin treatment, the experimental group was given glucocorticoid treatment on the basis of the control group.The clinical efficacy, antipyretic time, cough relief time, pulmonary rales disappearance time, hospitalization time, occurrence of adverse reactions after treatment were compared between the two group. The C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), procalcitonin (PCT) levels were compared between the two groups before and after treatment. Results The total effective rate of the experimental group was higher than that of the control group, and the difference was statistically significant (P<0.05). The cough relief time, hospitalization time, fever reduction time and lung rales disappearance time in the experimental group were all shorter than those in the control group, and the differences were statistically significant (P<0.05). There were no significant differences in the levels of CRP, ESR and PCT between the two groups before treatment (P>0.05). After treatment, the levels of CRP, ESR and PCT in the two groups were lower than those before treatment and the differences were statistically significant (P<0.05). And the CRP, ESR and PCT levels of the experimental group were lower than those of the control group, and the differences were statistically significant(P<0.05). The total incidence of adverse reactions in the experimental group was lower than that in the control group,and the difference was statistically significant (P>0.05).Conclusion Glucocorticoid assisted Azithromycin in the treatment of Mycoplasma pneumoniae infected lobar pneumonia in children can not only effectively regulate the immune function of children, reduce the release of inflammatory factors, shorten the treatment time and improve the curative effect, but also will not increase the adverse reactions in the treatment process, worthy of clinical application. 2022 Vol. 29 (9): 23-26 [Abstract] ( 56 ) HTML (1 KB)  PDF (542 KB)  ( 31 ) 27 Evaluation of ultrasound signs combined with pathological and biological indexes for vascular infiltration of breast invasive ductal carcinoma CHEN Yanquan;Li Jia;Deng Minjun Objective To investigate the relationship between ultrasonic features, clinicopathological and biological indicators and lymphovascular invasion of invasive ductal breast carcinoma. Methods A total of 108 patients with invasive ductal breast carcinoma treated in the Department of Breast of Guangdong Second Traditional Chinese Medicine Hospital from January 2017 to April 2021 were selected retrospectively as the study subjects. They were divided into group with lymphovascular invasion (63 cases) and group without lymphovascular invasion (45 cases) according to the postoperative pathological results. The relationship between ultrasonic features, clinicopathological and biological indicators of invasive ductal breast carcinoma and lymphovascular invasion of invasive ductal breast carcinoma were analyzed. The value of four ultrasonic features of abnormal axillary lymph nodes in diagnosis of lymphovascular invasion in invasive ductal breast carcinom was also assessed. Results Univariate analysis of ultrasonic features showed that invasive ductal breast carcinomas showed more irregular shape, non-parallel orientation, internal microcalcification, posterior echo attenuation and abnormal axillary lymph nodes in the lymphovascular invasion group, with statistically significant differences (P<0.05). Multivariate logistic regression analysis showed that irregular morphology (β=2.093, OR=8.106, 95%CI=1.634-40.207) and abnormal axillary lymph nodes (β=2.509, OR=12.287, 95%CI=4.464-33.822) were independent risk factors for lymphovascular invasion in invasive ductal breast carcinoma respectively (P<0.05). Univariate analysis of clinicopathological and biological indicators showed that more proliferating cell nuclear antigen-67 (Ki-67) ≥20% and TNM stage 3 were found in the lymphovascular invasion group of invasive ductal breast carcinoma, with statistically significant differences (P<0.05). There were no statistically significant differences in the area under the ROC between the four features of ultrasonographic abnormal axillary lymph nodes and their combined diagnosis (P>0.05). Conclusion Irregular morphology of mass and abnormal axillary lymph nodes are independent risk factors for lymphovascular invasion in invasive ductal breast carcinoma respectively. Combined with clinicopathological and biological indicators, it is meaningful to assess lymphovascular invasion of invasive ductal breast carcinoma, and provides a useful basis for prognostic assessment and adjuvant treatment of breast cancer. 2022 Vol. 29 (9): 27-31 [Abstract] ( 32 ) HTML (1 KB)  PDF (756 KB)  ( 10 ) 32 Application progress of Sacubitril Valsartan in heart failure and other diseases FANG Min1；ZHAO Zuqin1；ZHONG Xuanming1；SHI Jiaqi1；LIU Zhida1；LI Xuefeng2 The drug treatment of chronic heart failure has changed from strengthening heart, diuresis and vasodilation to inhibiting neuroendocrine. As a new generation of neuroendocrine inhibitor, Sacubitril Valsartan has been paid more and more attention in recent years. It has been found that its efficacy is not only limited to patients with heart failure with reduced ejection fraction (HFrEF), but also benefit patients with non-HFrEF. In addition, existing studies have shown that Sacubitril Valsartan shows superiority in heart failure complicated with other diseases. This paper reviews the efficacy of Sacubitril Valsartan in the treatment of non-HFrEF and heart failure complicated with other diseases,and looks forward to the application of Sacubitril Valsartan in a wider population. 2022 Vol. 29 (9): 32-36 [Abstract] ( 36 ) HTML (1 KB)  PDF (423 KB)  ( 37 ) 37 Research progress of knee-saving surgery for knee osteoarthritis XU Panfeng；WEI Yanguo▲；LIANG Jiongwen；YANG Shangrong；ZHOU Yuanlin Knee osteoarthritis （KOA）is one of the common diseases in the field of orthopedics, which seriously affects the quality of life of patients. At present, the commonly used knee sparing surgical treatment schemes include arthroscopic surgery, high tibial osteotomy (HTO), unicondylar joint replacement (UKA) and proximal fibula osteotomy (FO).Each surgical procedure has its advantages and disadvantages, and the choice of surgical method is a topic of discussion in the medical field recently. In order to explore the clinical efficacy of four kinds of knee sparing surgery for knee osteoarthritis, this study is to summarize and conclude some recent methods of knee sparing surgery in KOA. The advantages and disadvantages, indications and complications of four types of KOA knee sparing surgery were reviewed.According to the analysis of its curative effect, each surgical technique has its advantages and limitations. If there is little trauma, quick recovery, low cost, less damage to other bone tissues, and no impact on other surgical plans in the future, peroneal osteotomy and knee arthroscopy can be given priority. For early and young patients, high tibial osteotomy can be used in pursuit of greater mobility. In elderly patients, in order to reduce postoperative complications and revision rate, knee joint single condyle replacement can be selected. At the same time of choosing surgical plan, we should consider many factors to make an appropriate surgical plan for patients. 2022 Vol. 29 (9): 37-40 [Abstract] ( 37 ) HTML (1 KB)  PDF (412 KB)  ( 38 ) 41 Research on the environmental adaptability of a new type of portable infusion controller YU Juhong；ZHAI Baohua；ZOU Yan；CHENG Bo；CHENG Hongbo Objective To evaluate the environmental adaptability of a newly developed portable infusion controller.Methods The environmental adaptability data of the new portable infusion controller (the experimental group) and the traditional infusion controller (the control group) from December 2020 to March 2021 in the same researchers and research environment were collected. The environmental adaptability of the two groups in terms of alarm/shutdown indicators was evaluated through in vitro simulation of left-right shaking, and up-down shaking, as well as real-world simulation of walking, going up and down stairs, going out for inspection, going to the bathroom, pre hospital first aid and field transportation. Each environment was observed 100 times. Results When simulating shaking interference in vitro,the shaking degree of left-right shaking of the experimental group was (32.42±4.27)°, which was higher than (15.36±5.58)° of the control group, the difference was statistically significant (P＜0.05). When shaking up and down, the pullup of the experimental group was (1.33±0.08) times, which was higher than (1.16±0.05) times in the control group, the difference was statistically significant (P＜0.05). In the real simulation experiment, the alarm/shutdown rate of the experimental group in all operation scenarios was lower than that of the control group, the difference was statistically significant (P＜0.05). When simulating the scenes of extremely slow walking, slow walking, going up and down stairs, going out for inspection, going to the bathroom,normal driving of ambulances and transfer of field stretchers, the alarm/shutdown rate of the experimental group were 0%, indicating full adaptation to the environment, while in the control group, different degrees of alarm/shutdown under the above environment reported. Conclusion The new portable infusion controller not only has the advantage of accurate control, but also has better environmental adaptability. It can expand the application range of speed limited infusion and better serve hospitals and patients. 2022 Vol. 29 (9): 41-44 [Abstract] ( 25 ) HTML (1 KB)  PDF (700 KB)  ( 28 ) 45 Application effect of different dressings based on the Branden pressure ulcer risk assessment scale score in the prevention of nasal and facial pressure ulcers with non-invasive ventilator WAN Jing；HUANG Jie；CHEN Rehua Objective To explore the preventive effect of using different dressings based on the Branden pressure ulcer risk assessment scale (Branden) score on non-invasive ventilator nasal and facial pressure ulcers. Methods A total of 84 non-invasive ventilator-ventilated patients who were admitted to the First Hospital of Nanchang City in Jiangxi Province from July 2019 to July 2021 were selected as the research subjects. They were divided into observation group and control group by random number table method, with 42 cases in each group. Patients in the control group were given routine pressure ulcer prevention intervention, and patients in the observation group selected different dressings for preventive intervention based on the Branden score. The incidence of nasal and facial pressure ulcers, comfort level,and treatment compliance between the two groups were compared. Results The total incidence of nasal and facial pressure ulcers in the observation group was lower than that in the control group, the comfort level was better than that in the control group, and the total treatment compliance was higher than that in the control group, and the differences were statistically significant (P<0.05). Conclusion The use of different dressings based on the Branden score to intervene in patients treated with non-invasive ventilator can effectively prevent the occurrence of nasal and facial pressure ulcers, and improve the patients′ physical and mental comfort and treatment compliance. 2022 Vol. 29 (9): 45-47转54 [Abstract] ( 33 ) HTML (1 KB)  PDF (650 KB)  ( 57 ) 48 Expression levels and clinical significance of urinary L-FABP, NGAL,KIM-1, and β2-MG kidney injury markers in patients with chronic obstructive pulmonary disease XU Jinxiong；CAO Dongdong；CAO Xiaoquan Objective To analyze the expression levels of kidney injury markers including urinary hepatic fatty acidbinding protein (L-FABP), neutrophil gelatinase-associated lipocalin (NGAL), kidney injury molecule-1 (KIM-1) and β2-microglobulin (β2-MG) in patients with chronic obstructive pulmonary disease (COPD) and their clinical significance. Methods A total of 90 COPD patients who were treated into the Third People′s Hospital of Jiujiang City from January 2020 to June 2021 were selected as the observation group. According to different arterial oxygen partial pressure (PaO2), they were divided into the observation group 1 (60 mmHg < PaO2 ≤85 mmHg), the observation group 2 (40 mmHg < PaO2 ≤60 mmHg), and the observation group 3 (PaO2 ≤40 mmHg). Meanwhile, 50 healthy volunteers who underwent physical examinations in the Third People′s Hospital of Jiujiang City during the same period were selected as the control group. All four groups were deprived of water after 8:00 pm, and urine samples were collected from the clean mid-section in the next morning. L-FABP, NGAL, and KIM-1 were detected by enzyme-linked immunosorbent assay, and β2-MG was detected by immunoturbidimetric method. The levels of urinary L-FABP, NGAL,KIM-1, and β2-MG in the observation group, each subgroup, and the control group were compared, and the correlation between L-FABP, NGAL, KIM-1, and β2-MG and PaO2 were analyzed. Results The levels of L-FABP, NGAL,KIM-1, and β2-MG in the observation group 3 were higher than those in the observation group 1, the observation group 2, and the control group, the levels of L-FABP, NGAL, KIM-1, and β2-MG in the observation group 2 were higher than those in the observation group 1 and the control group, the levels of L-FABP, NGAL, KIM-1, and β2-MG in the observation group 1 were higher than those in the control group, with statistical differences (P<0.05). Pearson correlation test showed that the levels of L-FABP, NGAL, KIM-1, and β2-MG were negatively correlated with PaO2 (P<0.05).Conclusion PaO2 in COPD patients is correlated with the levels of L-FABP, NGAL, KIM-1, and β2-MG. The measurement of urinary L-FABP, NGAL, KIM-1, and β2-MG levels can reflect early renal injury. With the severity of hypoxia, the renal damage of the patients also aggravates, which can provide a reference for the early intervention and treatment of COPD. 2022 Vol. 29 (9): 48-50 [Abstract] ( 35 ) HTML (1 KB)  PDF (652 KB)  ( 13 ) 51 Clinical study of ultrasound monitoring gastric emptying and preventing reflux aspiration in elderly patients following strategy of enhanced recovery after surgery WANG Chao；LI Yongyi；HUANG Yimin；CHEN Zhenhua；HU Siguang；CAI Xingjian Objective To study and analyze the clinical effect of ultrasound monitoring gastric emptying and preventing reflux aspiration in elderly patients following enhanced recovery after surgery (ERAS) strategy. Methods From July to December 2020, a total of 60 elderly patients who underwent elective upper abdominal surgery in Jiangmen Wuyi Hospital of Traditional Chinese Medicine and Kaiping Hospital of Traditional Chinese Medicine were selected as the research subjects. According to random number table, they were randomly divided into a control group with 30 cases and a experimental group with 30 cases. The patients in the control group were asked to keep fasting state from 22:00 p.m. before operation. The patients in the experimental group were asked to drink 400 ml carbohydrate 2 hours before operation. After entering the anesthesia preparation room, the patients in the two groups were monitored by ultrasound for gastric emptying and the risk of reflux aspiration. The gastric volume, antral cross-sectional area, gastric volume to body mass ratio and the risk of reflux aspiration were compared between the two groups. Results There were no significant differences in gastric volume, antral cross-sectional area, gastric volume to body mass ratio and reflux aspiration risk between the two groups (P>0.05). Conclusion For the elderly patients who follow ERAS strategy, the ultrasound is useful in monitoring the gastric emptying and preventing the reflux aspiration. 2022 Vol. 29 (9): 51-54 [Abstract] ( 34 ) HTML (1 KB)  PDF (739 KB)  ( 28 ) 55 Risk factors of postoperative delirium in patients undergoing postoperative spinal surgery under general anesthesia LUO Yingchao；HU Yongyu；SHEN Yinyan；SU Jingru；LIANG Mei；YAN Qingyue Objective To investigate the risk factors of postoperative delirium in patients undergoing spinal surgery under general anesthesia. Methods In a retrospective analysis of the clinical data of 935 patients treated with elective general anesthesia surgery in the Department of Spinal Surgery of North Guangdong People′s Hospital from October 2019 to September 2020, they were divided into non-delusion group (n=877) and delusion groups (n=58) according to whether there were delusions within 1 week after surgery. The gender, age, body mass index (BMI), smoking history,combined basic disease, operation time, intraoperative bleeding, postoperative hypoxemia, hemoglobin (Hb) levels in each group were analyzed. The postoperative risk factors were analyzed. Results The results of the univariate analysis showed that the patient′s age, pain pump use, blood loss, postoperative Hb, BMI value, type 2 diabetes, history of stroke disease, operation time, hypertension, and chronic obstructive pulmonary disease history were the postoperative related factors (P<0.05). The results of the multivariate analysis showed that the long operation time, old age, history of stroke disease and hypertension were the independent high risk factors for the postoperative delusion in patients with general anesthesia spinal disease (P<0.05). Conclusion The high risk factors for patients with spinal surgery include old age, stroke history, hypertension, too long operation time, etc. It is necessary for relevant staff to work well and reduce the incidence of postoperative delirium in patients after surgery. 2022 Vol. 29 (9): 55-57 [Abstract] ( 36 ) HTML (1 KB)  PDF (617 KB)  ( 15 ) 58 Application study of inflatable polymer gel body position pad design and lithotomy position surgery GAO Yuanyan；LI Zhen Objective To investigate the application effect of inflatable polymer gel body position pad in lithotomy position surgery. Methods The data of 100 patients who underwent lithotomy position surgery in the First Affiliated Hospital of Gannan Medical College from January to June 2020 were retrospectively analyzed, and they were divided into the control group and the study group according to their position pads, with 50 patients in each group. The control group used conventional cotton position pad, and the study group used inflatable polymer gel body position pad. The hemodynamic indexes (central venous pressure [CVP], systolic blood pressure [SBP], and diastolic blood pressure [DBP]), Braden pressure sore score, visual analog scale (VAS) score, pressure sore and the occurrence of adverse reactions and comfort level of the two groups were compared. Results After operation, the levels of CVP, SBP and DBP in the study group were higher than those in the control group, the differences were statistically significant (P＜0.05). The Braden score of the study group was higher than that of the control group, while the VAS score of the study group was lower than that of the control group, the differences were statistically significant (P＜0.05). The total incidence of pressure sore in the study group was 4.00%, which was significantly lower than that of 16.00% in the control group, the difference was statistically significant (P＜0.05). The incidence of adverse reactions in the study group was 6.00%, which was lower than that of 20.00% in the control group, the difference was statistically significant (P＜0.05). The comfort degree of the study group was 98.00%, which was higher than that of 84.00% of the control group, the difference was statistically significant (P＜0.05). Conclusion The application of inflatable polymer gel body position pad in the operation of lithotomy position and the placement of body pads can not only reduce the incidence of pressure sore, but also improve the hemodynamics of patients, improve the comfort of patients,and reduce the occurrence of adverse reactions. 2022 Vol. 29 (9): 58-61 [Abstract] ( 36 ) HTML (1 KB)  PDF (626 KB)  ( 29 ) 62 Clinical characteristics and risk factors of nosocomial infections in patients with acute stroke LI Jun GONG Haihua Objective To analyze the clinical characteristics and risk factors of nosocomial infection in patients with acute stroke. Methods From February to November 2021, 180 patients with acute stroke who were admitted to Qidong People′s Hospital of Jiangsu Province for treatment were selected as the research objects, and the incidence, clinical characteristics and risk factors of nosocomial infection in the patients during treatment were analyzed. Results The incidence of nosocomial infection in 180 patients after treatment was 15.00% (27/180), among which the incidence of lower respiratory tract infection was high. Univariate analysis showed that there were significant differences in age of infected persons, complications, use of proton pump inhibitors, sedative drugs, Glasgow Coma Score (GCS), degree of neurological deficit of National Institute of Health Stroke Scale (NIHSS), ability of daily living (ADL) scores, preventive application of antibiotics, length of hospital stay and muscle strength between infected patients and non-infected patients (P＜0.05). Multivariate analysis showed that age ≥60 years old, with complication, use of sedative drugs and proton pump inhibitors, GCS score ＜8 points, NIHSS score ≥15 points, ADL score ＜50 points, preventive application of antibiotics, length of hospital stay ＞20 days, muscle strength ≤3 were the high-risk factors of nosocomial infection in patients with acute stroke (P＜0.05). Conclusion The incidence of nosocomial infection in patients with acute cerebral stroke is high. In infection prevention, it is necessary to strengthen the management of controllable factors such as drugs and daily living ability to achieve the purpose of improving the prognosis of patients. 2022 Vol. 29 (9): 62-65 [Abstract] ( 31 ) HTML (1 KB)  PDF (624 KB)  ( 22 ) 66 Clinical value of combination of serum alpha-fetoprotein, alpha-fetoprotein heterosomes and phosphatidylinositol proteoglycan 3 in the diagnosis of hepatocellular carcinoma LI Hui；ZHAO Juan；XU Peiyan；ZHANG Chengfang；TAN Lijuan；LIU Meisan Objective To study the clinical value of serum alpha-fetoprotein (AFP), alpha-fetoprotein-L3 (AFP-L3)and glypican-3 (GPC3) in the combined diagnosis of hepatocellular carcinoma (HCC). Methods A total of 136 Patients with suspected HCC diagnosis in the People′s Hospital of Huadu District, Guangzhou City from April 2018 to March 2021 were selected as the HCC group, 129 patients with benign liver diseases were selected as the benign group, and 140 patients with hepatitis and cirrhosis treated in the People′s Hospital of Huadu District, Guangzhou City during the same period were selected as the control group. The serum levels of AFP, AFP-L3, and GPC3 in the three groups were detected and compared. Postoperative liver biopsy was used as the gold standard to evaluate the value of AFP, AFPL3, and GPC3 for the diagnosis of HCC alone or in combination. Results The levels of AFP, AFP-L3, and GPC3 in the HCC group were higher than those in the benign group and the control group, and the levels of AFP, AFP-L3 and GPC3 in the benign group were higher than those in the control group,and the differences were statistically significant(P<0.05).The sensitivity, specificity, negative predictive value, positive predictive value and accuracy of AFP, AFP-L3, and GPC3 combined diagnosis for HCC were higher than AFP, AFP-L3, and GPC3 alone or in combination. Conclusion Serum AFP, AFP-L3, and GPC3 are closely related to HCC. Detection of their levels is helpful for the clinical diagnosis of HCC, and combined detection of the three can significantly improve the diagnosis rate of HCC. 2022 Vol. 29 (9): 66-69 [Abstract] ( 35 ) HTML (1 KB)  PDF (398 KB)  ( 21 ) 70 Expression and clinical significance of miR-1915-3p and Bcl-2 in colon cancer tissues YAO Xiaohui Objective To study the expression and clinical significance of miR-1915-3p and Bcl-2 in colon cancer tissues. Methods A total of 85 colon cancer patients admitted to the Second Hospital of Chaoyang City, Liaoning Province from February 2013 to February 2016 were selected as the research subjects. The cancer tissues and normal adjacent tissues of all patients were collected, and the mRNA expression levels of miR-1915-3p and Bcl-2 in different colon tissues were detected and compared by RT-qPCR. The expression levels of miR-1915-3p and Bcl-2 mRNA in different clinicopathological features and prognosis of colon cancer patients were analyzed. Results The expression level of miR-1915-3p mRNA in colon cancer tissues was lower than that in normal adjacent tissues, while the expression level of Bcl-2 mRNA was higher than that in normal adjacent tissues, the differences were statistically significant (P<0.05). The miR-1915-3p mRNA expression level of colorectal cancer patients with TNM stage Ⅲ-Ⅳ, low differentiation and lymph node metastasis were lower than those of colorectal cancer patients with TNM stage Ⅰ-Ⅱ, medium and high differentiation and no lymph node metastasis, the expression level of Bcl-2 mRNA were higher than those of patients with stage Ⅰ-Ⅱ, medium and high differentiation and no lymph node metastasis, the differences were statistically significant (P<0.05). The expression level of miR-1915-3p mRNA in patients with colon cancer death was lower than that in patients with survival, and the expression level of Bcl-2 mRNA was higher than that in patients with survival, the differences were statistically significant (P<0.05). Conclusion MiR-1915-3p is low expression in colon cancer tissues, while Bcl-2 is high expression in colon cancer tissues, and the expression levels of miR-1915-3p and Bcl-2 are different in patients with different TNM stages, degrees of differentiation, lymph node metastasis and prognosis. 2022 Vol. 29 (9): 70-73 [Abstract] ( 33 ) HTML (1 KB)  PDF (419 KB)  ( 22 ) 74 Application effect of Phloroglucinol cervical injection combined with Foley urinary catheter in pregnant women who need to induce labor in the third trimester of pregnancy ZOU Yinxia；ZHANG Jinyi；WANG Shan Objective To investigate the application effect of phloroglucinol cervical injection combined with Foley urinary catheter in pregnant women who need to induce labor in the third trimester of pregnancy. Methods From January 2020 to July 2021, 120 pregnant women in the third trimester of pregnancy who were required to induce labor in Pingxiang Maternal and Child Health Hospital were selected as the research objects. According to the random number table method, they were divided into the control group 1 (40 cases), the control group 2 (40 cases) and the observation group (40 cases). The control group 1 patients were treated with Foley catheters, the control group 2 patients were treated with Phloroglucinol, and the observation group patients were treated with the combination of the above two groups. The pregnant women in the three groups were observed for 12 h. The cervical maturity, delivery and labor process time, postpartum hemorrhage and adverse reactions of the three groups were compared. Results The total effective rate of the observation group were higher than those of the control group 1 and the control group 2, and the total incidence of adverse reactions of the observation group were lower than those of the control group 1 and the control group 2, the time of delivery and labor of the observation group were shorter than those of the control group 1 and the control group 2, and the postpartum hemorrhage of the observation group were less than those of the control group 1 and the control group 2, the differences were statistically significant (all P＜0.05). Conclusion Phloroglucinol cervical injection combined with Foley urinary catheter can effectively promote the cervical ripening of pregnant women in the third trimester, shorten the birth process and reduce adverse reactions. 2022 Vol. 29 (9): 74-76 [Abstract] ( 31 ) HTML (1 KB)  PDF (400 KB)  ( 28 ) 77 Clinical study of auricle appliances in the treatment of congenital auricle deformities in children ZOU Yun；YUAN Hua；FU Ronghua；JIN Pingliang Objective To observe the clinical effect of auricle appliances in the treatment of congenital auricle deformities in children. Methods A total of 32 infants with congenital auricle deformities treated with auricle appliances in the Jiangxi Provincial Children′s Hospital from May 2018 to May 2019 were selected. According to the Byrd classification,there were cryptotia (n=14), lop ears (n=8), cup ear (n=2), protruding ears (n=2), helix deformities (n=4), and mixed deformities (n=2). They were divided into the younger group (0-3 months) and the elder group (3-6 months) according to age, with 16 cases in each group. Photographs were taken before and after treatment, with a period of 2 to 4 weeks. The curative effects of children after wearing were observed. Results After the treatment, the auricle morphologies were evaluated by family members and doctors jointly, which were divided into excellent (same as normal ears), good (basically normal), and poor (no change or slight improvement). All auricle deformities were improved, 29 cases (90%) were evaluated as excellent, and 3 cases (10%) were good. Two of the children had skin eczema, and one had small skin ulcers, which improved 3 days after topical application of erythromycin ointment. No obvious complications were observed in the remaining ears. After 1 year, there was no recurrence in the re-examination. Conclusion Auricle appliances have an obvious effect on non-invasive treatment of auricle deformities, and the earlier the correction is implemented,the better the effect is. The auricle appliances have a low incidence of adverse reactions and a short wearing time,which can avoid later surgical treatment and psychological hazards. The auricle appliances are easy to operate and promote, becoming the first choice for the treatment of auricle deformities. 2022 Vol. 29 (9): 77-79转90 [Abstract] ( 35 ) HTML (1 KB)  PDF (461 KB)  ( 41 ) 80 Analysis of prognostic factors of anti-vascular endothelial growth factor drugs in the treatment of diabetic macular edema WANG Shuna；GAO Wuqin；DENG Haibo Objective To analyze the prognostic factors of patients with diabetic macular edema(DME) treated with anti vascular endothelial growth factor (VEGF) drugs. Methods The clinical data of 82 patients with DME who were treated and followed up in Yingtan people′s Hospital from January 2019 to May 2020 were retrospectively analyzed. According to the visual acuity level after treatment, patients with best corrected visual acuity (BCVA) ≥0.3 were divided into group A (62 cases) and patients with BCVA<0.3 were divided into group B (20 cases). Logistic regression analysis was used to analyze the prognostic factors of DME patients treated with VEGF. Results Univariate analysis showed that there were statistically significant differences in age, DME typing, DME stage and penetration degree between the two groups (P<0.05). Multivariate analysis showed that DME was localized (β=1.324，OR=3.746，95%CI=2.112-6.635),DME stage Ⅳ-Ⅴ(β=1.442，OR=4.229，95%CI=2.299-7.780) and permeability ≥500 μm (β=1.348，OR=3.850，95%CI=2.130-6.958) were risk factors for poor prognosis of DME patients treated with anti VEGF drugs (P<0.05). Conclusion DME localized type, DME stage Ⅳ-Ⅴ, permeability ≥500 μm were the influencing factors of poor prognosis in patients with DME treated with anti VEGF drugs, can provide targeted guidance for DME treatment. 2022 Vol. 29 (9): 80-82 [Abstract] ( 25 ) HTML (1 KB)  PDF (402 KB)  ( 94 ) 83 Effect of Conbercept combined with laser photocoagulation in the treatment of diabetic macular edema WANG Zichuan；ZHANG Xiaomei；LI Caibao Objective To explore the effect of Conbercept combined with laser photocoagulation in the treatment of diabetic macular edema. Methods A total of 120 patients with diabetic macular edema who were admitted to Jingdezhen Second People′s Hospital from June 2020 to May 2021 were selected as the research subjects, and they were divided into the control group (60 patients, 60 eyes) and the observation group (60 patients, 60 eyes) by the random number table method. The control group was treated with laser photocoagulation, and the observation group was treated with Conbercept combined with laser photocoagulation. The blood flow density in macular area was compared between the two groups before and after 4 months of treatment. Macular center thickness and best corrected visual acuity were compared between the two groups before treatment and 1, 2 and 4 months after treatment. Results After 4 months of treatment, the blood flow density in the superficial and deep macular areas of the two groups were higher than those before treatment, and the blood flow density in the superficial and deep macular areas in the observation group after 4 months of treatment were higher than those in the control group, the differences were statistically significant (P<0.05). The best corrected visual acuity levels of the two groups at 1, 2 and 4 months after treatment were higher than those before treatment, the best corrected visual acuity levels of the two groups after 2 and 4 months of treatment were higher than those after 1 month of treatment, the best corrected visual acuity levels after 4 months of treatment of the two groups were lower than those after 2 months of treatment, the best corrected visual acuity levels of observation group after 1, 2 and 4 months of treatment were higher than those in the control group, and the differences were statistically significant (P<0.05). The thickness of macular center levels in the two groups after 1, 2 and 4 months of treatment were lower than those befo re treatment, the thickness of macular center levels in the two groups after 2 and 4 months of treatment were lower than those after 1 month of treatment, the thickness of macular center levels in the two groups after 4 months of treatment were lower than those after 2 months of treatment, the thickness of macular center levels of observation group after 1, 2 and 4 months of treatment were lower than those in the control group, and the differences were statistically significant (P<0.05). Conclusion Combined with laser photocoagulation, Conbercept can effectively relieve the clinical symptoms of diabetic macular edema, inhibit the increase of macular center thickness and improve visual function, and has a significant therapeutic effect. 2022 Vol. 29 (9): 83-86 [Abstract] ( 34 ) HTML (1 KB)  PDF (412 KB)  ( 81 ) 87 Clinical application of acupoint stimulation and regulation method in patients with severe hepatitis YU Rongyan；ZHANG Fang；DUAN Tiantian；KANG Feifei；FAN Xia；HU Yiting；TU Fenglan Objective To explore the clinical application of acupoint stimulation and regulation method in patients with severe hepatitis. Methods A total of 100 patients with severe hepatitis admitted to the Second Affiliated Hospital of Nanchang University from January 2020 to December 2020 were selected as the research objects, and divide into a control group and an observation group by the random number table method, with 50 cases in each group. The control group received conventional treatment, and the o bservation group received conventional treatment combined with acupoint stimulation and regulation method. The anxiety score, sleep quality and treatment satisfaction of the two groups were compared. Results After treatment, the self-rating anxiety scale score of the observation group was lower than that of the control group, and the difference was statistically significant (P<0.05). Before treatment, there were no statistical significances in subjective sleep quality, time to fall sleep, sleep time, sleep efficiency, sleep disorder, use of sleeping drugs and daytime functional scores between the two groups (P>0.05). After treatment, subjective sleep quality,time to fall sleep, sleep time, sleep efficiency, sleep disorder, use of sleeping drugs and daytime function scores in observation group were lower than those in control group, the differences were statistically significant (P<0.05). The total satisfaction of patients in the observation group was higher than that of the control group, and the difference was statistically significant (P<0.05). Conclusion Implementing acupoint stimulation control method for patients with severe hepatitis can relieve patients′ anxiety, optimize sleep quality, and improve patients′ satisfaction with treatment. 2022 Vol. 29 (9): 87-90 [Abstract] ( 31 ) HTML (1 KB)  PDF (562 KB)  ( 26 ) 91 Clinical effect of Jieyu Prescription combined with acupuncture in the treatment of aphasia after ischemic stroke WANG Zhiqiang；ZHU Yuan；JIANG Yaofeng Objective To observe the clinical effect of Jieyu Prescription combined with acupuncture in the treatment of aphasia after ischemic stroke. Methods A total of 85 patients with aphasia after ischemic stroke in the Department of Encephalology of Nanjing Integrated Traditional Chinese and Western Medicine Hospital from June 2018 to December 2020 were selected and divided into control group (n=43) and observation group (n=42) according to random number table method. The patients in the control group were treated with symptomatic treatment and speech rehabilitation training for stroke. The observation group was treated with traditional Chinese medicine decoction Jieyu Prescription and acupuncture. Two groups were treated for 2 weeks. The clinical effect of the two groups before and after treatment were observed and compared. Results After treatment, the scores of language function of the two groups were higher than those before treatment, the differences were statistically significant (P<0.05). The listening comprehension, oral expression, retelling and writing scores in the observation group were better than those in the control group, the differences were statistically significant (P<0.05). The total effective rate of the observation group was higher than that of the control group, the difference was statistically significant (P<0.05). Conclusion Jieyu Prescription combined with acupuncture and moxibustion in the treatment of ischemic stroke aphasia can significantly improve the aphasia symptoms, reduce the severity of aphasia, and improve the clinical curative effect. 2022 Vol. 29 (9): 91-94转98 [Abstract] ( 38 ) HTML (1 KB)  PDF (586 KB)  ( 77 ) 95 Application of wrist ankle acupuncture in insomnia patients with chronic hepatitis B of liver depression and spleen deficiency type WANG Yongfang；ZHUO Xiaoying；ZHAO Jing；LUO Xiaoliang；HAN Zhiyi Objective To investigate the clinical effect of wrist ankle acupuncture on insomnia patients with chronic hepatitis B of liver depression and spleen deficiency type. Methods From April 10, 2020 to January 3, 2021, 100 patients who admitted to Shenzhen Hospital of Traditional Chinese Medicine with chronic hepatitis B insomnia of liver depression and spleen deficiency type were selected as the research objects. They were divided into treatment group and control group by coin tossing method, with 50 cases in each group. The treatment group was treated with liver protecting and enzyme reducing therapy and wrist ankle acupuncture, while the control group was treated with liver protecting and enzyme reducing therapy. Two weeks later, the efficacy, insomnia severity index (ISI) scale score, alanine aminotransferase (ALT), aspartate aminotransferase (AST) and total bilirubin (TBil) levels in the two groups were compared. Results The total effective rate in treatment group was higher than that in control group, and the difference was statistically significant (P<0.05). After treatment, ISI score in the treatment group was lower than that in the control group, the difference was statistically significant (P<0.05). After treatment, ALT and AST in the treatment group were lower than those in the control group, the differences were statistically significant (P<0.05). After treatment, there was no statistically significant difference in TBil between the two groups (P>0.05). Conclusion Wrist and ankle needle application in chronic hepatitis B insomnia patients with liver depression and spleen deficiency can effectively improve insomnia, improve liver function, promote disease recovery, and the operation is simple and convenient,can be popularized in clinical application. 2022 Vol. 29 (9): 95-98 [Abstract] ( 31 ) HTML (1 KB)  PDF (590 KB)  ( 33 ) 99 Clinical effect of thunder fire moxibustion combined with Jian′er Fanggan Decoction in the treatment of children with recurrent respiratory tract infections of lung-spleen-qi deficiency FU Shiqiang Objective To explore the clinical effect of thunder fire moxibustion combined with Jian′er Fanggan Decoction in the treatment of lung-spleen-qi deficiency recurrent respiratory tract infection. Methods A total of 67 children with lung-spleen-qi deficiency and recurrent respiratory tract infection who received treatment in the First Maternal and Child Health Hospital of Huizhou City, Guangdong Province from January 2019 to June 2021 were selected as the research objects.They were divided into the research group(n=34)and the control group(n=33)according to random number table method. The control group was treated with Jian′er Fanggan Decoction. The research group used thunder fire moxibustion combined with Jian′er Fanggan Decoction for treatment. Main symptoms before and after treatment of traditional Chinese medicine (include shaohua, sweat, stool stem node), secondary symptoms (god fatigue, cough, shortness of breath,oral color light)integral,immune factors(immunoglobulin M[IgM],immunoglobulin A [IgA], immunoglobulin G[IgG]), inflammation factors (interleukin-6 [IL-6]and interleukin-10 [IL-10], C-reactive protein [CRP]) were compared between the two groups before and after the treatment. Results After treatment, the scores of primary and secondary syndromes in the study group were lower than those in the control group, and the differences were statistically significant (P<0.05). After treatment, the levels of IgM, IgA and IgG in the study group were higher than those in the control group, and the differences were statistically significant (P<0.05). After treatment, the levels of IL-6, IL-10 and CRP in the study group were lower than those in the control group, and the differences were statistically significant (P<0.05).Conclusion Thunder fire moxibustion combined with Jian′er Fanggan Decoction can effectively improve the clinical symptoms and signs of children with recurrent respiratory tract infection of spleen-qi deficiency, effectively enhance their immune function and control the level of serum inflammatory factors. The combined efficacy of the two is high,and it is suggested to be further promoted in clinical application. 2022 Vol. 29 (9): 99-102 [Abstract] ( 33 ) HTML (1 KB)  PDF (588 KB)  ( 15 ) 103 Application of acupoint massage in the management of community essential hypertension CHEN Peng；KUANG Cheng；XU Huanhuan Objective To explore the application effect of acupoint massage in the management of community essential hypertension. Methods A total of 200 patients with community essential hypertension treated in Shibaqiao Branch of Jingdezhen Second People′s Hospital from April 2020 to August 2021 were selected as subjects and divided into control group and observation group according to random number table method, with 100 cases in each group. The control group was treated with Western medicine, and the observation group was treated with acupoint massage on the basis of the treatment method of the control group. Both groups were followed up for 8 weeks. The standard rate of blood pressure control, blood pressure level, traditional Chinese medicine syndrome score and quality of life were compared between the two groups. Results The compliance rate of blood pressure in the observation group (97.00%) was higher than that in the control group (90.00%), the difference was statistically significant (P<0.05). The levels of systolic and diastolic blood pressure in the observation group were lower than those in the control group, the differences were statistically significant (P<0.05). After the intervention, the scores of dizziness, headache, heavyness in the head, chest tightness,vomiting, sputum and saliva in the observation group were lower than those in the control group, the differences were statistically significant (P<0.05). After intervention, the scores of physiological function, social function, somatic pain and overall health in the observation group were higher than those in the control group, the differences were statistically significant (P<0.05). Conclusion Acupoint massage can enhance the effect of blood pressure control and improve clinical symptoms and quality of life. 2022 Vol. 29 (9): 103-106 [Abstract] ( 33 ) HTML (1 KB)  PDF (558 KB)  ( 33 ) 107 Effect study of vegetable oil as a preservative in 24 h urine protein quantitative specimens LI Guangying；FENG Zhigang；YAO Wei；DING Wen Objective According to the principle of isolating air and inhibiting bacterial growth, the application effect of vegetable oil as preservative for the preservation of 24 h urine protein quantitative specimens was studied. Methods From November 2020 to September 2021, 30 samples of urine routine and urine visible component analysis in Shenzhen Bao′an Traditional Chinese Medicine Hospital were selected as the research subjects. The semi-quantitative results of urine protein were ±, 1+, 2+, 3+ and 4+ as screening criteria, and 6 samples were selected from each gradient.The samples were divided into experimental group and comparison group with 30 samples in each group. The quantitative results of urine protein in the comparison group were detected by biochemical analyzer and used as the comparison value, In the experimental group, the samples were sealed with vegetable oil as liquid level and isolated from air. The samples were placed at room temperature for 24 h, and the quantitative results of urinary protein were detected by biochemical analyzer again as the test value, the quantitative results of urinary protein were compared between the two groups. Results There was no significant difference in urine protein between experimental group and comparison group(P>0.05). The relative bias was (-1.37±8.25) %, and there was no significant difference between the two groups (P>0.05). According to the scheme in the CLSI guideline EP15-A2 of using patient specimens to verify the accuracy of the two methods, the absolute value of the relative bias of the test group and the comparison group was calculated to be 1.37%, which was less than the 1/2 allowable total error standard used by clinical laboratories, 22%. Conclusion Vegetable oil can be used for 24 h urine protein quantitative sample storage at room temperature, vegetable oil preservatives have the advantages of easy material, economic safety, convenient operation, suitable for popularization. 2022 Vol. 29 (9): 107-110转114 [Abstract] ( 35 ) HTML (1 KB)  PDF (462 KB)  ( 39 ) 111 Correlation analysis between Chlamydia trachomatis, Mycoplasnm genitalium and female infertility YUAN Xiaowen；YUAN Shiyun；LIANG Jingxing；WU Guoxin；WU Zhixin；ZHANG Xin；GUAN Ziyun Objective To explore the relationship between Chlamydia trachomatis (CT), Mycoplasma genitalium (Mg)and female infertility. Methods From January 2016 to March 2018, 165 female infertility patients who visited Nanhai District People′s Hospital of Foshan were selected as the case group, and 100 healthy women were set as control group at the same time. RT-PCR was used to detect Mg and CT, and enzyme-linked immunosorbent assay was used to detect anti-endometrial antibody (EmAb) in serum. The positive rate of Mg and CT in the two groups, the positive rate of EmAb in Mg or CT positive and negative patients in the case group, and the correlation between genital CT and Mg infection and female infertility were compared. Results The positive rates of Mg and CT in case group were higher than those in control group, the differences were statistically significant (P<0.05). In the case group, the positive rate of EmAb in Mg and CT positive patients was higher than that in Mg and CT negative patients, the difference was statistically significant(P<0.05). Spearman correlation analysis showed that reproductive tract CT and Mg infection were positively correlated with infertility (P<0.05). Conclusions CT and MG are significantly correlated with female infertility. CT and MG and EmAb can be used as an important and effective method to diagnose female infertility. 2022 Vol. 29 (9): 111-114 [Abstract] ( 28 ) HTML (1 KB)  PDF (460 KB)  ( 24 ) 115 Influencing factors and countermeasures of apheresis platelet donor loss LI Minling；LIN Qimin Objective To explore the related factors affecting the loss of apheresis platelet donors and put forward constructive strategies for platelet donor retention. Methods Based on the central Blood bank database management system of Zhaoqing City, 3073 platelet donors from the central blood bank database of Zhaoqing City from January 2014 to December 2018 were selected as subjects for retrospective analysis. The loss rate of apheresis platelet donors was analyzed and the influencing factors of blood loss were analyzed. Results Among 3073 subjects, blood donors were enrolled in a control group of 1935 platelet donors again or repeatedly within 24 months of their first platelet donation,1138 patients who donated only once were included in the observation group, and the loss rate of platelet donors was 37.03%. Univariate analysis showed that there were statistically significant differences in age, gender, self-perceived health status, occupation, education level, cognition level of blood donation, motivation of blood donation and experience of blood donation between the two groups (P<0.05). Multivariate analysis showed that age, cognition level of blood donation, motivation of blood donation and experience of blood donation were the influencing factors for loss of apheresis platelet donors (P<0.05). Conclusion According to the causes of platelet donor loss and related factors, which to formulate platelet donor retention strategies and improve the quality of blood donation service, so as to reduce platelet donor loss and improve the success rate of new recruitment plan. 2022 Vol. 29 (9): 115-117转121 [Abstract] ( 30 ) HTML (1 KB)  PDF (771 KB)  ( 25 ) 118 Analysis of influencing factors of frequent attenders of a community hospital in Beijing LU Jinghui；ZHANG Nan；DU Juan Objective To analyze the causes of frequent attenders by multivariate logistic regression analysis. Methods A total of 5221 patients were retrospectively selected as the research objects who attended the General Outpatient Clinic of Anzhen Community Health Service Center, Chaoyang District, Beijing, from January 2020 to December 2020. Patients were divided into two groups by number of attendances. Frequent attenders group was who attended> 24 times per year; Non-frequent attenders group who attended ≤24 times per year. Influencing factors were compared between two groups. To find risk factors of frequent attenders by multivariate logistic regression analysis. Results Age, coronary heart disease, hypertension, type 2 diabetes, osteoarthropathy, osteoporosis, cerebrovascular disease, hyperlipidemia,chronic obstructive pulmonary disease and total number of chronic diseases in frequent attenders group were higher than those in non-frequent attenders group by single factor analysis, the difference were statistically significant (P<0.05). The risk factors of frequent attended were elderly patients (β=0.12, OR=1.22, 95%CI=1.07-1.38), coronary heart disease (β=0.51, OR=1.66, 95%CI=1.45-1.91), osteoarthropathy (β=0.55, OR=1.74, 95%CI=1.20-2.52), chronic obstructive pulmonary disease (β=0.71, OR=2.04, 95%CI=1.76-2.37) and the total number of chronic diseases (β=0.78,OR=2.19, 95%CI=1.89-2.54) by multivariate logistic regression analysis （P<0.05）. Conclusion Elderly patients, coronary heart disease, osteoarthropathy, chronic obstructive pulmonary disease and the total number of chronic diseases were risk factors of frequent attended. 2022 Vol. 29 (9): 118-121 [Abstract] ( 28 ) HTML (1 KB)  PDF (458 KB)  ( 75 ) 122 Qualitative study of cognitive status of ICU acquired weakness among ICU nurses JIANG Weihan；ZHOU Wei；CHEN Mengzhu；LIU Yanling；YE Zufeng；CHEN Li Objective To understand the knowledge and experience of intensive care unit (ICU) nurses on intensive care unit acquired weakness (ICU-AW), and to provide reference for the development of intervention programs on ICUAW. Methods From January to April 2021, 10 ICU nurses in the Affiliated Nanhua Hospital, Hengyang Medical School, University of South China were interviewed with semi-structured interviews on their knowledge of ICU-AW,and the data were analyzed by subject analysis method. Results Four themes were extracted from the interview results:ICU nurses′ limited cognition of ICU-AW, ICU nurses′ insufficient attention to ICU-AW, ICU nurses′ few ways to learn ICU-AW related knowledge, and the reasons for ICU nurses′ inability to acquire ICU-AW knowledge. Conclusion ICU nurses still lack the knowledge of ICU-AW, and it is necessary to pay more attention to it and strengthen training and learning, so as to provide a good basis for the development and implementation of ICU-AW intervention measures. 2022 Vol. 29 (9): 122-125转129 [Abstract] ( 31 ) HTML (1 KB)  PDF (851 KB)  ( 98 ) 126 Exploration and practice of optimizing management mode of outpatient service process for chronic disease patients based on Internet plus WANG Li；JIN Juan；ZHENG Chunyan Objective To explore the application effect of the optimized management mode of outpatient service process for chronic diseases patients based on Internet +. Methods A total of 170 patients with chronic diseases admitted to the outpatient of the Second People′s Hospital of Shangrao from March 2019 to March 2021 were selected as the research objects, and they were divided into control group and observation group according to the order of admission, with 85 cases in each group. The control group adopted routine management, and the observation group adopted process optimization management based on "Internet +". The outpatient appointment rate, complaint rate, visit time and nursing satisfaction were compared between the two groups. Results The outpatient appointment rate in the observation group was higher than that in the control group, and the complaint rate was lower than that in the control group, the differences were statistically significant (P＜0.05). The registration time, visiting time, charging time and taking time of the observation group were shorter than those of the control group, the differences were statistically significant (P＜0.05). The score of nursing satisfaction in the observation group was higher than that in the control group in terms of medical environment, medical treatment,privacy protection, communication and service attitude, the differences were statistically significant (P ＜0.05).Conclusion The process optimization management mode based on the Internet plus can improve the appointment rate of outpatients with chronic diseases, reduce the incidence of nursing complaints, shorten the time of patients′ visit and promote the satisfaction of nursing. 2022 Vol. 29 (9): 126-129 [Abstract] ( 38 ) HTML (1 KB)  PDF (555 KB)  ( 207 ) 130 Application effect of classification management programs for rescue vehicles LI Qin；HE Jing；HAN Dan；HUANG Xiaoming Objective To explore the application effect of classification management programs for rescue vehicles.Methods The usage situations of 71 rescue vehicles from General Hospital of Pingxiang Mining Group Co., Ltd. and Pingxiang Second People′s Hospital before the implementation of classification management programs were retrospectively analyzed between January and December 2018. The classification management programs for rescue vehicles were formulated based on this and officially clinically applied between January and December 2020. Before and after the implementation of hierarchical management scheme, the loss of expired drugs in the rescue vehicle, waste amount of money, total spending time of rescue vehicles management and satisfaction of medical staffs with management programs were compared. Results After the implementation of hierarchical management plan, the amount of expired drugs and the consumption amount of rescue vehicles were lower than before, the differences were statistically significant (P<0.05). The quality control times of rescue car department, the quality control times of nursing department and the quality control time of nursing staff in the department were lower than before, the differences were statistically significant(P<0.05). A total of 71 medical staff participated in the satisfaction evaluation of this study protocol, After the implementation of hierarchical management scheme, the total satisfaction of medical staff was higher than before, the difference was statistically significant (P<0.05). Conclusion The classification management programs of rescue vehicles are of clinical application value, which can reduce drugs waste and improve work efficiency of quality control, with high plans satisfaction in medical staffs. 2022 Vol. 29 (9): 130-132 [Abstract] ( 30 ) HTML (1 KB)  PDF (565 KB)  ( 16 ) 133 Practice and experience of fine management reform of hospital consumables PENG Lihong Medical consumables are becoming more and more refined, and the purchase volume is increasing sharply.As a necessity in the medical process, the management of consumables directly affects the daily operation of hospitals and the life safety of patients. How to achieve safe and effective fine management of consumables has become an urgent demand of all major hospitals. This article will pass before and after the elaborating management of medical consumable materials for flow, logistics and distribution management of medical consumables, warehouse and distribution before and after implementing the management of medical consumables refinement process variation, selection and distribution of human resources management to study the four sorts of evolution on improve the management mechanism of chaos, and reduce the resource waste and other issues. The aim is to bring reference and help to the general hospital consumable management workers. 2022 Vol. 29 (9): 133-136 [Abstract] ( 37 ) HTML (1 KB)  PDF (745 KB)  ( 38 ) 137 Current situation and development of professional and technical title promotions in health management research in Beijing CHANG Zhengying Since August 2014, Beijing has comprehensively promoted the qualification examination and evaluation of professional and technical positions in health management research in its affiliated medical and health institutions, the promotion channel has opened up for health management personnel, the treatment problem has been solved, and the management team of the hospital has been stabilized. The promotion procedures, such as examination, defense and evaluation, on which the personnel′s initiative on modern hospital management technology was actively motivated, and their consciousness of in-depth study on hospital management issues has been motivated, provided a strong guarantee for the smooth progress of the new medical reform in Beijing. At the same time, it also founds that there are some problems in the professional title system, such as the disunity of the position definition, the failure of independent verification of management positions, the crowded number of health professional and technical positions, the lack of unified and professional continuing education programs, and short of supporting assessment and salary system after promotion.Therefore, to make the promotion of professional title play an active role, this essay puts forward suggestions on improving the post setting, developing the continuing education program, and refining the supporting performance system, etc. 2022 Vol. 29 (9): 137-140 [Abstract] ( 30 ) HTML (1 KB)  PDF (541 KB)  ( 9 ) 141 Effect of comprehensive management intervention strategy on nosocomial infection of multidrug resistant organism in hospitalized patients SHAN Yonglan；MENG Jianfeng Objective To explore the effect of comprehensive management intervention strategy on nosocomial infection of multidrug resistant organism (MDRO) in hospitalized patients. Methods A total of 14 402 patients hospitalized in the Department of Surgery of Yancheng Third People′s Hospital from January 2019 to October 2021 were selected as the research objects, 6810 patients treated during the implementation of routine management from January 2019 to May 2020 as the control group, and 7592 patients treated during the implementation of comprehensive management intervention strategy from June 2020 to October 2021 as the observation group. The detection rate of MDRO, nosocomial infection, the compliance rate of medical staff to various prevention and control measures were compared between the two groups. Results There was no significant difference in the detection rate of MDRO in specific bacteria between the two groups (P>0.05). The hospital infection rate of MDRO in the observation group was lower than that in the control group, and the compliance rate of medical staff to various prevention and control measures was higher than that in the control group, the differences were statistically significant (P<0.05). Conclusion The implementation of comprehensive management intervention strategy is conducive to improve the compliance rate of medical staff with nosocomial infection prevention and control measures and reduce the risk of MDRO infection. 2022 Vol. 29 (9): 141-143转147 [Abstract] ( 30 ) HTML (1 KB)  PDF (902 KB)  ( 18 ) 144 Effect of health education under the focus solution model on motor function and rehabilitation process of patients with osteoporotic fracture HE Ling；WANG Le Objective To explore the application effect of health education under the focus solution model in patients with osteoporotic fracture. Methods A total of 82 patients with osteoporotic fractures treated in Jiujiang Hospital of Traditional Chinese Medicine from October 2019 to October 2021 were selected as subjects. They were divided into control group (41 cases) and intervention group (41 cases) according to random number table method. The control group received routine health education, and the intervention group received health education under the focus solution model.Intervention lasted for 1 month in both groups. The motor function (Fugl-Meyer assessment [FMA]), mental state (symptom checklist-90 [SCL-90]) and fracture healing effect, complications and hospital stay were compared between the two groups before and after intervention. Results Before intervention, there were no significant differences in FMA and SCL-90 scores between the two groups(P>0.05).After the intervention,the FMA scores of the two groups were higher than those before the intervention, the SCL-90 scores of the two groups were lower than those before the intervention, the FMA score of the intervention group was higher than that of the control group, and the SCL-90 score was lower than that of the control group, with statistically significant differences (P<0.05). The excellent and good rate of fracture healing in the intervention group was higher than that in the control group, the total incidence of complications was lower than that in the control group, and the length of hospital stay was shorter than that in the control group, with statistically significant differences(P<0.05). Conclusion Health education under the focus solution model is helpful to improve the motor function and psychological state of patients with osteoporotic fracture, and speed up the rehabilitation process. 2022 Vol. 29 (9): 144-147 [Abstract] ( 27 ) HTML (1 KB)  PDF (592 KB)  ( 25 ) 148 Analysis and countermeasures of teaching problems in pharmaceutical engineering YANG Peng；SU Wuyue；HONG Xuechuan；XIAO Yuling  Pharmaceutical engineering is an interdisciplinary subject covering chemistry, pharmacy and engineering. It plays an important role in the cultivation of talents in the pharmaceutical industry. In order to keep up with the demand of the development of the pharmaceutical industry for pharmaceutical engineering professionals, combined with the teaching practice of the School of Pharmaceutical Sciences, Wuhan University in talent training over the years deeply analyzed the problems existing in the teaching contents, teaching methods and examination methods of pharmaceutical engineering courses. On this basis, the countermeasures are given from the aspects of renewing teaching plan, diversified teaching mode, opening up the "second classroom" and establishing a multi-dimensional evaluation system. "There is no end to learning, no end to teaching and no end to research". The school of pharmacy of Wuhan University should continue to explore diversified teaching and research methods, take teaching problems as the guidance, and promote the effective implementation of efficient classroom while promoting teachers′ professional growth through problem-based teaching design and experimental arrangement, so as to constantly find and solve problems in teaching, and actively meet the practical needs of the rapid development of medical science and technology for the teaching reform of pharmaceutical engineering course. 2022 Vol. 29 (9): 148-150 [Abstract] ( 49 ) HTML (1 KB)  PDF (548 KB)  ( 33 ) 151 Application effect of problem-based learning and case-based learning combined with Three-Dimensional visualization technology in teaching of Hepatobiliary Surgery DONG Zhitao；FANG Kunpeng；SUI Chengjun；GENG Li Objective To explore the application effect of problem-based learning and case-based learning combined with Three-Dimensional visualization technology in hepatobiliary surgery teaching. Methods A total of 68 clinical medical students enrolled in Shanghai East Hospital of Hepatobiliary Surgery from January to September 2021 were selected as the experimental subjects of this study. The students were divided into experimental group and control group by digital random table, with 34 cases in each group. The control group adopted the traditional teaching mode, while the experimental group adopted the new teaching method of problem-based learning and case-based learning combined with Three-Dimensional visualization technology. The teaching indexes of the two groups were compared by teaching scale evaluation method: theoretical achievement, anatomical achievement and total achievement, and also clinical practice skills were scored. Results The anatomical scores and total scores of the experimental group were higher than those of the control group, with statistically significant differences (P<0.0001). The scores and total scores of various clinical practice skills of the experimental group were higher than those of the control group, with statistically significant differences (P<0.0001). Conclusion It is difficult to teach hepatobiliary surgery interns, but problem-based learning and case-based learning combined with Three-Dimensional visualization technology can improve the teaching mode, make students master the anatomy of hepatobiliary system more easily, and effectively improve the teaching quality and efficiency. 2022 Vol. 29 (9): 151-153转157 [Abstract] ( 27 ) HTML (1 KB)  PDF (570 KB)  ( 73 ) 154 Exploration and practice of pharmacognosy project teaching method based on innovation and entrepreneurship education CAI Le；ZHOU Hao；WEI Kun；CHEN Yang Colleges and universities pay more and more attention to the innovation and entrepreneurship education of college students in the process of talent training. Improving the innovation and entrepreneurship ability of college students has become the focus of college teaching reform. Pharmacognosy is an important professional course for pharmacy and pharmaceutical engineering. It mainly describes the name, source, production, processing, identification, chemical constituents and medical use of crude drugs. It is divided into two parts: general and monographs. The content of monographs is scattered and complex. It′s difficult for conventional teaching methods to cultivate students′ interest in learning. Pharmacognosy is highly applicable and practical, and involves a wide range of disciplines. Integrating innovation and entrepreneurship education into the pharmacognosy teaching can produce innovative projects with practical value.This article proposes to combine innovation and entrepreneurship education with pharmacognosy course teaching, connect scattered pharmacognosy knowledge through project teaching method, comprehensively expound the implementation plan of project teaching method and the select of innovation project. This kind of project teaching method can effectively increase the interest and innovation of teaching, stimulate students′ potential for independent learning, consolidate the foundation of students′ pharmacognosy, encourage students to flexibly apply their professional knowledge to carry out innovation and entrepreneurship. 2022 Vol. 29 (9): 154-157 [Abstract] ( 29 ) HTML (1 KB)  PDF (659 KB)  ( 59 ) 158 Application of problem-originated clinical medical curriculum combined with problem-based learning in clinical nursing teaching of cardiovascular surgery XIONG Rui；LI Ya Objective To explore the application effect of problem-originated clinical medical curriculum (PCMC) combined and problem-based learning (PBL) in nursing teaching of cardiovascular surgery. Methods A total of 50 nursing students who practiced in cardiovascular surgery in Chongqing hospital of University of Chinese Academy of Sciences from December 2019 to December 2020 were selected as the research objects, they were randomly divided into control group and observation group, with 25 in each group. The control group was taught by routine nursing teaching method,and the observation group was taught by PCMC and PBL. The problem-solving ability, graduation theory and operation assessment results and teaching satisfaction of nursing students in the two groups were compared. Results There was no significant difference in the total score of problem-solving ability and the scores of each dimension between the two groups at the time of admission (P>0.05). The total score of problem-solving ability and the scores of each dimension of the two groups at the time of graduation were higher than those at the time of admission, the differences were statistically significant (P<0.05). At graduation, the total score of problem-solving ability and the scores of each dimension, the scores of graduation theory and operation assessment, and the scores of teaching satisfaction of nursing students in the observation group were higher than those in the control group,the differences were statistically significant(P<0.05).Conclusion The combined application of PCMC and PBL in cardiovascular surgery nursing teaching can optimize the quality of cardiovascular surgery practice teaching, promote the improvement of nursing students′ theoretical knowledge level and operation practice ability, and improve nursing students′ problem-solving ability and satisfaction with teaching. 2022 Vol. 29 (9): 158-161 [Abstract] ( 41 ) HTML (1 KB)  PDF (593 KB)  ( 48 ) 162 Effect of comprehensive nursing intervention on the quality of life and lung function of elderly patients with chronic obstructive pulmonary disease in stable stage LI Lu Objective To explore the application effect of comprehensive nursing intervention in elderly patients with chronic obstructive pulmonary disease (COPD). Methods A total of 88 elderly patients with COPD treated in Pingxiang People′s Hospital from May 2018 to May 2021 were selected as the research objects for retrospective analysis. Patients were divided into study group (44 cases) and control group (44 cases) according to different nursing plan. The patients in the control group were treated with routine nursing mode and the patients in the observation group were treated with comprehensive nursing intervention mode. The differences of lung function, quality of life, sleep quality and mental state were compared between the two groups before and after nursing. Results The scores of forced expiratory volume in the first second (FEV1), forced vital capacity (FVC), FEV1/FVC, and the MOS item short from health survey (SF-36) in the study group were higher than those in the control group at 3 months after nursing, the differences were statistically significant (P<0.05). The scores of Pittsburgh sleep quality scale (PSQI), self-rating anxiety scale (SAS) and self-rating depression scale (SDS) in the study group were lower than those in the control group at 3 months after nursing, and the differences were statistically significant (P<0.05). Conclusion The application of comprehensive nursing intervention model in elderly patients with COPD can improve patients′ respiratory function, reduce anxiety and depression, improve sleep quality and quality of life, which is worthy of further clinical promotion. 2022 Vol. 29 (9): 162-165转170 [Abstract] ( 36 ) HTML (1 KB)  PDF (699 KB)  ( 22 ) 166 Application of integrated traditional Chinese and Western medicine clinical nursing pathway management in patients with schizophrenia LIANG Xiaoli；ZHAO Ruilin；LI Meizhi；NING Qiuxiang Objective To investigate the effect of integrated traditional Chinese and Western medicine clinical nursing pathway on patients with schizophrenia. Methods The clinical data of 234 schizophrenic patients admitted to Hunan Brain Hospital from June 2017 to June 2018 were retrospectively analyzed, and they were divided into control group(116 cases) and experimental group (118 cases) according to different treatment methods. Patients in the control group were treated with routine nursing of schizophrenia, and patients in the experimental group were treated with clinical nursing path combining Chinese and Western nursing. The length of stay, hospitalization cost, hospitalization times within 2 years, positive and negative symptom scale (PANSS) scale, insight and treatment attitude questionnaire (ITAQ)score before and after treatment, efficacy and the relationship between length of stay, hospitalization cost, hospitalization times within 2 years and post treatment scale score were compared between the two groups. Results The length of stay of the experimental group was shorter than that of the control group, the hospitalization cost was lower than that of the control group, and the hospitalization times within 2 years was less than that of the control group, the differences were statistically significant (P<0.05). After treatment, the positive symptoms, negative symptoms, general symptoms and total PANSS score of PANSS in the two groups were lower than those before treatment, and the ITAQ scores were higher than those before treatment, the differences were statistically significant (P<0.01). After treatment, the positive symptoms, negative symptoms, general symptoms and total PANSS scores of the experimental group were lower than those of the control group, and the ITAQ scores were higher than those of the control group, the differences were statistically significant (P<0.05). The therapeutic effect of experimental group was better than that of the control group, and the difference was statistically significant (P<0.05). The hospitalization cost of patients was positively correlated with PANSS positive symptoms and total percentage after treatment (P<0.05). The number of hospitalizations within 2 years was positively correlated with PANSS (P<0.05). Conclusion Integrated traditional Chinese and Western medicine clinical nursing pathway management is beneficial to improve the clinical symptoms and insight of patients with schizophrenia, and can shorten hospital stay, reduce hospitalization costs and hospitalization times in good economic benefits, which is worthy of further promotion. 2022 Vol. 29 (9): 166-170 [Abstract] ( 31 ) HTML (1 KB)  PDF (654 KB)  ( 25 ) 171 Effect of nursing and rehabilitation program on acquired dysphagia in mechanical ventilation patients DU Jinlei；NIE Chencong；LEI Ling；YUAN Wenjie；WU Xiaoling；WU Yulian；LIU Anzhong；CHEN Li Objective To explore the effect of nursing and rehabilitation program in mechanical ventilation patients with acquired dysphagia.Methods A total of 60 patients who received mechanical ventilation treatment from June to August 2021 were selected as the research objects, and randomly divided into the control group and the observation group by random number table method, with 30 patients in each group. The control group was mainly treated with conventional nursing intervention, and the observation group was systematically managed by nursing rehabilitation program on the basis of the control group. The Watian′s drinking water test, swallowing disorders grade 7 evaluation results and surface electromyography evaluation results were compared between the two groups of patients before nursing, 3 and 7 days after nursing. Results There were no statistically significant differences between the two groups in the evaluation results of Watian′s drinking water test assessment results, swallowing dysfunction magnitude 7 assessment results and methods of electrical diagram evaluation results before nursing (P>0.05). The Watian′s drinking water test evaluation results, swallowing disorder in patients with magnitude 7 assessment results and methods of electric diagram assessment results in the observation group were better than those in the control group 3 and 7 days after nursing, the differences were statistically significant (P<0.05). The Watian′s drinking water test assessment results, swallowing dysfunction magnitude 7 assessment results in the control group 7 days after nursing were better than those before nursing,and the differences were statistically significant (P<0.05). The Watian′s drinking water test assessment results, swallowing dysfunction magnitude 7 assessment results in the observation group 3 and 7 days after were better than those before nursing, the differences were There was statistically significance (P<0.05). Conclusion Nursing rehabilitation program can effectively promote the recovery of symptoms of acquired dysphagia in mechanical ventilation patients. 2022 Vol. 29 (9): 171-175 [Abstract] ( 31 ) HTML (1 KB)  PDF (684 KB)  ( 204 ) 176 Application effect of nutritional intervention in nursing care of elderly patients with osteoporotic fracture LI Wenjing；LEI Ruiyu Objective To explore the effect of nutritional intervention in the nursing of elderly patients with osteoporotic fractures. Methods A total of 68 elderly patients with osteoporotic fractures admitted to the Department of Geriatrics of Jiujiang First People′s Hospital from January to December 2020 were selected as the research objects, and were divided into control group (34 cases) and observation group (34 cases) according to the random number table method. The control group received routine intervention, and the observation group was given nutrition intervention. The motor function (FMA), life activity ability (Barthel index), quality of life and nursing satisfaction of the two groups were compared.Results There were no significant differences in FMA and Barthel index between the two groups before nursing (P>0.05). After nursing, the FMA and Barthel indexes of the two groups were higher than those before nursing, and the scores of the observation group were higher than those of the control group, the differences were statistically significant(P<0.05). There was no significant difference in scores of quality of life between the two groups before nursing (P>0.05).After nursing, the scores of quality of life in both groups were higher than before nursing, and the observation group were higher than those in the control group, the differences were statistically significant (P<0.05). Nursing satisfaction of observation group was higher than control group, the difference was statistically significant (P<0.05). Conclusion In the nursing of elderly patients with osteoporotic fracture, nutritional intervention has a significant effect, which can effectively promote the improvement of patients′ motor function and living activity ability, and then improve the quality of life and nursing satisfaction of patients. It is feasible to popularize. 2022 Vol. 29 (9): 176-178转182 [Abstract] ( 27 ) HTML (1 KB)  PDF (656 KB)  ( 31 ) 179 Effect of evidence-based nursing model on breastfeeding self-efficacy of women with high-risk pregnancy YAO Juanjuan；WU Haiying；ZHANG Yingzi Objective To explore the effect of evidence-based nursing mode on self-efficacy of breastfeeding in highrisk pregnant women. Methods A total of 120 primiparas with high-risk pregnancy admitted by Fuzhou Maternal and Child Health Hospital from January 2019 to June 2021 were selected as the research objects, and divided into control group and observation group according to random number table method, with 60 cases in each group. The control group took routine nursing mode, and the observation group took evidence-based nursing mode. The scores of breastfeeding self-efficacy (BSES) and nursing satisfaction were compared between the two groups. The two groups were followed up for 6 months after delivery to compare the breastfeeding rate. Results There was no significant difference in BSES scores between the two groups before nursing (P>0.05). After nursing, the BSES score of the two groups was higher than that before nursing, and the observation group was higher than the control group, the differences were statistically significant (P<0.05). The total nursing satisfaction of the observation group was higher than that of the control group, the difference was statistically significant (P<0.05). The breastfeeding rate of the observation group was higher than that of the control group at 1 d and 6 months postpartum, and the differences were statistically significant (P<0.05). Conclusion Evidence-based nursing model can improve breastfeeding self-efficacy and breastfeeding rate of high-risk pregnant women, and obtain higher nursing satisfaction, which is worthy of clinical promotion. 2022 Vol. 29 (9): 179-182 [Abstract] ( 35 ) HTML (1 KB)  PDF (641 KB)  ( 33 ) 183 Effect of targeted psychological care for patients with CT enhancement on bad mood and extravasation of scanning contrast agent ZHENG Yajun；GONG Xinghong Objective To explore the effect of targeted psychological care for patients with CT enhancement on bad mood and extravasation of scanning contrast agent. Methods A total of 136 patients underwent CT enhanced examinations admitted to Xianning First People′s Hospital from May 2019 to April 2021 were selected as the research subjects,they were divided into observation group and control group according to the random number table method, with 68 patients in each group. Patients in the control group were received conventional psychological intervention, and patients in the observation group were received targeted psychological nursing intervention. The bad mood and the incidence of extravasation of the scanning contrast agent were compared between the two groups. Results After the intervention, the scores of the self-rating anxiety scale (SAS) and the self-rating depression scale (SDS) of the two groups were lower than those before the intervention, the scores of the observation group were lower than those of the control group, the differences were statistically significant (P<0.05). The total incidence of scanning contrast agent extravasation in the observation group was lower than that in the control group, the difference was statistically significant (P<0.05). Conclusion The application of targeted psychological care in CT enhanced patients can alleviate negative emotions and reduce the incidence of scanning contrast agent extravasation. 2022 Vol. 29 (9): 183-185转189 [Abstract] ( 23 ) HTML (1 KB)  PDF (664 KB)  ( 29 ) 186 Application of ankle pump in prevention of deep vein thrombosis in patients with varicose veins of lower limbs NIE Jing；ZENG Guqing Objective To investigate the effect of ankle pump on reducing limb swelling and pain and deep vein thrombosis after varicose vein operation. Methods A total of 80 patients who received high ligation of unilateral limb great saphenous vein in Affiliated Tumor Hospital of Chongqing University from July 2018 to August 2020 were selected retrospectively and divided into control group and experimental group according to different methods of postoperative intervention, with 40 cases in each group. The control group received conventional nursing measures such as ankle pump exercise, and the experimental group used ankle pump auxiliary equipment on the basis of conventional nursing. The comparison of limb swelling index at the third day after surgery, the number of cases of limb pain requiring drug rescue within 72 hours after surgery, and the occurrence of deep vein thrombosis within 7 days after surgery were compared between the two groups. Results The swelling index of the experimental group was lower than that of the control group,and the difference was statistically significant (P<0.05). The number of cases requiring rescue of limb pain in the experimental group was less than that in the control group, and the difference was statistically significant (P<0.05). There were 2 cases of deep vein thrombosis in the control group (4.9%), there was no deep vein thrombosis in the experimental group, and there was no significant difference in the incidence of deep vein thrombosis between the two groups (P>0.05). Conclusion The application of auxiliary devices in patients with varicose veins can increase patients' postoperative compliance, effectively reduce postoperative limb swelling and pain, reduce the incidence of deep vein thrombosis and save social resources. 2022 Vol. 29 (9): 186-189 [Abstract] ( 30 ) HTML (1 KB)  PDF (640 KB)  ( 39 ) 190 Effect of evidence-based nursing combined with comfort nursing on patients with intracerebral hemorrhage FAN Linna Objective To explore the effect of evidence-based nursing combined with comfort nursing on complications,compliance and satisfaction of patients with intracerebral hemorrhage. Methods A total of 80 patients with intracerebral hemorrhage treated in the Department of Neurology of Jinqiu Hospital of Liaoning Province from April 2019 to November 2020 were selected as the research objects. They were divided into control group and observation group according to random number table method, with 40 cases in each group. The control group received routine nursing, and the observation group received evidence-based nursing combined with comfort nursing. The incidence of complications, medical compliance rate and nursing satisfaction score of two groups were compared. Results The total incidence of complications in the observation group was lower than that in the control group, the difference was stastically significant (P<0.05). The total compliance rate in the observation group was higher than that in the control group, the difference was stastically significant (P<0.05). The score of nursing satisfaction in the observation group was significantly higher than that in the control group, the difference was stastically significant (P<0.05). Conclusion The combination of evidencebased nursing and comfort nursing in patients with intracerebral hemorrhage can significantly reduce complications, improve their compliance, and have positive significance in improving the relationship between nurses and patients. 2022 Vol. 29 (9): 190-193 [Abstract] ( 26 ) HTML (1 KB)  PDF (882 KB)  ( 44 ) 194 Nursing effect of descending step thinking combined with SBAR emergency and ward transfer mode on patients with acute myocardial infarction ZHU Yan ZHOU Jing ZHUANG Jinxiu Objective To explore the nursing effect of descending step thinking combined with SBAR emergency and ward transfer mode on patients with acute myocardial infarction. Methods The clinical data of 86 patients with acute myocardial infarction admitted to Dalian Third People′s Hospital from April 2016 to September 2018 were retrospectively analyzed. According to different emergency schemes, they were divided into the control group (43 cases) and the study group (43 cases). The patients in the control group were given SBAR scheme, and the patients in the study group were given SBAR and descending step thinking. The success rate of emergency, hospitalization mortality, the recurrence rate, thrombolysis time, rescue time, hospitalization time and handover quality were compared between the two groups.Results The success rate of emergency in the study group was higher than that in the control group, and hospitalization mortality and the recurrence rate in the study group were lower than those in the study group, the differences were statistically significant (P<0.05). The thrombolysis time，rescue time and hospitalization time in the study group were shorter than those in the study group, the differences were statistically significant (P<0.05). The handover time in the study group was shorter than that in the control group, the incidence of handover problems in the study group was lower than that in the control group, and the differences were statistically significant (P<0.05). Conclusion The joint intervention of SBAR and descending step thinking in patients with acute myocardial infarction can shorten the hospitalization time,accelerate the recovery of the disease, improve the critical thinking ability of nurses, shorten the handover time, and improve the handover quality and critical thinking ability of nurses. 2022 Vol. 29 (9): 194-196 [Abstract] ( 26 ) HTML (1 KB)  PDF (644 KB)  ( 27 )

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