|
|
|
| Correlation analysis between Chlamydia trachomatis, Mycoplasnm genitalium and female infertility |
| YUAN Xiaowen1 YUAN Shiyun2 LIANG Jingxing3 WU Guoxin2 WU Zhixin4 ZHANG Xin5 GUAN Ziyun2▲ |
1. Department of Laboratory Medicine, Nanhai District People′s Hospital of Foshan, Guangdong Province, Foshan 528200, China;
2. Department of Emergency Medicine, Nanhai District People′s Hospital of Foshan, Guangdong Province, Foshan 528200, China;
3. Department of Medical Records Statistics Room, Nanhai Hospital of Guangdong Provincial People′s Hospital, Guangdong Province, Foshan 528251;
4. Department of Emergency Medicine, Foshan Hospital of Traditional Chinese Medicine, Guangdong Province, Foshan 528200, China;
5. Department of Gynaecology, Nanhai District People′s Hospital of Foshan, Guangdong Province, Foshan 528200, China |
|
|
|
|
Abstract Objective To explore the relationship between Chlamydia trachomatis (CT), Mycoplasma genitalium (Mg)and female infertility. Methods From January 2016 to March 2018, 165 female infertility patients who visited Nanhai District People′s Hospital of Foshan were selected as the case group, and 100 healthy women were set as control group at the same time. RT-PCR was used to detect Mg and CT, and enzyme-linked immunosorbent assay was used to detect anti-endometrial antibody (EmAb) in serum. The positive rate of Mg and CT in the two groups, the positive rate of EmAb in Mg or CT positive and negative patients in the case group, and the correlation between genital CT and Mg infection and female infertility were compared. Results The positive rates of Mg and CT in case group were higher than those in control group, the differences were statistically significant (P<0.05). In the case group, the positive rate of EmAb in Mg and CT positive patients was higher than that in Mg and CT negative patients, the difference was statistically significant(P<0.05). Spearman correlation analysis showed that reproductive tract CT and Mg infection were positively correlated with infertility (P<0.05). Conclusions CT and MG are significantly correlated with female infertility. CT and MG and EmAb can be used as an important and effective method to diagnose female infertility.
|
|
|
|
|
|
| [1] |
Quaas A，Dokras A.Diagnosis and Treatment of Unexplained Infertility[J].Rev Obstet Gynecol，2008，1（2）：69-76.
|
| [2] |
凌丽，凌秀花.女性不孕不育症相关因素及病因分析[J].世界最新医学信息文摘，2016，16（89）：225，234.
|
| [3] |
Babu G，Singaravelu BG，Srikumar R，et al.3 Comparative Study on the Vaginal Flora and Incidence of Asymptomatic Vaginosis among Healthy Women and in Women with Infertility Problems of Reproductive Age[J].J Clin Diagn Res，2017，11（8）：DC18-DC22.
|
| [4] |
Gharbaran R，Somenarain L.Insights into the molecular roles of Zika virus in human reproductive complications and congenital neuropathologies[J].Pathology，2017，49（7）：707-714.
|
| [5] |
乐杰.妇产科学[M].北京：人民卫生出版社，2004：381.
|
| [6] |
李靖，欧南城，叶晓涛，等.不孕妇女生殖道感染病原体检测分析[J].国际检验医学杂志，2014，35（11）：1395-1396.
|
| [7] |
王凯萍.410 例女性不孕患者生殖道支原体感染与输卵管阻塞情况分析[J].中国医师进修杂志，2014，37（3）：70-71.
|
| [8] |
Risser WL，Risser JM，Beamins LJ.Pelvic inflannnatom disease in adolescents between the time of tecting and treatment and after treat-meat for gonorrheal and Chlamvdial infection[J].Int J STD AIDS，2012，23（7）：457458.
|
| [9] |
方智淑，周协，张娜.女性生殖道支原体属感染与盆腔炎症关系临床分析[J].中华医院感染学杂志，2013，23（4）：855-857.
|
| [10] |
李会平.不孕不育夫妇生殖道解脲支原体、沙眼衣原体感染及抗精子抗体、抗子宫内膜抗体关系探讨[J].中国优生与遗传杂志，2014，22（1）：108-109，53.
|
| [11] |
王新芳.不孕不育夫妇生殖道感染解脲支原体和沙眼衣原体的临床探讨[J].中国医药指南，2016，14（1）：77-78.
|
| [12] |
游燕，王梦花，戴琼燕.生殖道支原体属及衣原体属感染与不孕的相关性[J].中华医院感染学杂志，2013，23（22）：5620-5621，5626.
|
| [13] |
王书侠，张家明，吴凯，等.女性生殖道支原体感染现状及耐药性监测[J].医学研究生学报，2013，26（12）：1286-1288.
|
| [14] |
张洁.探讨不孕不育患者的心理特点及护理方式[J].齐齐哈尔医学院学报，2014，2（19）：2958-2959.
|
| [15] |
何宏月，任小苗，呼红英，等.血清ENA-78、EMAb 水平与子宫内膜异位症患者病变特征的相关性[J].疑难病杂志，2021，20（7）：704-707，711.
|
| [16] |
郑颖惠，陈璇琼.理气活血方联合孕三烯酮在卵巢型子宫内膜异位症腹腔镜保守性手术后的应用效果[J].中国当代医药，2021，28（14）：177-180.
|
|
|
|
