肿瘤相关自身抗体联合肿瘤标志物对肺癌的诊断价值

Abstract
Figure/Table
References (20)
Related Citation (15)

Download: PDF (535 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To explore the diagnostic value of serum 7 tumor associated autoantibodies (7-TAABS) and tumor markers in lung cancer. Methods A total of 149 patients with lung cancer admitted to the First Affiliated Hospital of Xi′an Jiao Tong University from December 2020 to July 2021 were selected as the lung cancer group, and 86 patients with benign lung disease were selected as the control group. The levels of p53, PGP9.5, SOX2, GAGE7,GBU4-5, MAGE-A1, CAGE antibodies and 3 tumor markers (squamous cell carcinoma [SCC], carcinoembryonic antigen[CEA]and cytokeratin 19 fragment [CYFRA21-1]) were compared between two groups, the diagnostic efficacy of 7-TAABs and tumor markers in lung cancer were analyzed. Results Serum levels of 3 tumor markers and p53, PGP9.5,SOX2, GAGE7, GBU4-5 and MAGE-A1 in 7-Taabs in lung cancer group were higher than those in control group, the differences were statistically significant (P<0.05). The positive rate of 7-TAABS combined with 3 tumor markers was higher than that of the control group, the difference was statistically significant (P<0.05). The sensitivity, accuracy and negative predictive value of 7-TAABS combined with 3 tumor markers were 83.22%, 79.15% and 71.26%, respectively.Conclusion The combined detection of 7-TAABs and traditional tumor markers can improve the diagnostic efficiency and provide basis for the diagnosis and screening of lung cancer.

Key words： Autoantibody Tumor markers Combined detection Diagnosis

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors

Cite this article:

URL:

https://www.dangdaiyiyao.com/EN/ OR https://www.dangdaiyiyao.com/EN/Y2022/V29/I9/15

[7]	邹小农，贾漫漫，王鑫，等.《2020 全球癌症报告》要点解读[J].中国胸心血管外科临床杂志，2021，28（1）：11-18.
[8]	蔡学琴，王保龙.肺癌自身抗体对肺结节良恶性鉴别的临床价值[J].临床输血与检验，2020，22（1）：82-85.
[9]	Kauczor HU，Baird AM，Blum TG，et al.ESR/ERS statement paper on lung cancer screening[J].Eur Radiol，2020，30（6）：3277-3294.
[1]	刘宗超，李哲轩，张阳，等.2020 全球癌症统计报告解读[J].肿瘤综合治疗电子杂志，2021，7（2）：1-14.
[2]	Tomasetti M，Amati M，Neuzil J，et al.Circulating epigenetic biomarkers in lung malignancies：From early diagnosis to therapy[J].Lung Cancer，2017，107：65-72.
[3]	Tang ZM，Ling ZG，Wang CM，et al.Serum tumor-associated autoantibodies as diagnostic biomarkers for lung cancer：A systematic review and meta-analysis[J].PloS one，2017，12（7）：e0182117.
[4]	霍云丽，郭子建.肺癌自身抗体在肿瘤早期诊断和治疗中的临床应用进展[J].标记免疫分析与临床，2019，26（5）：887-891.
[5]	綦霞，孙丽娟，郭连英，等.肿瘤自身抗体检测对早期肺癌的诊断价值[J].中国微生态学杂志，2021，33（3）：301-303，308.
[6]	中华医学会，中华医学会肿瘤学分会，中华医学会杂志社.中华医学会肺癌临床诊疗指南（2018 版）[J].中华肿瘤杂志，2018，40（12）：935-964.
[10]	Yang B，Li X，Ren T，et al.Autoantibodies as diagnostic biomarkers for lung cancer：A systematic review[J].Cell Death Discov，2019，5（2）：126.
[11]	Macdonald IK，Parsy-Kowalska CB，Chapman CJ.Autoantibodies：Opportunities for Early Cancer Detection[J].Trends Cancer，2017，3（3）：198-213.
[12]	Oliveira G，Petronilho EC，Pedrote MM，et al.The status of p53 oligomeric and aggregation states in cancer[J].Biomolecules，2020，10（4）：548．
[13]	高成磊，黄猛，伦立民.自身抗体在肺癌临床诊断中的研究进展[J].国际检验医学杂志，2019，40（23）：2916-2921.
[14]	Vural B，Chen L C，Saip P，et al.Frequency of SOX Group B（SOX1，2，3）and ZIC2 antibodies in Turkish patients with small cell lung carcinoma and their correlation with clinical parameters[J].Cancer，2005，103（12）：2575-2583.
[15]	贺侠琴，王伟琦，邓凯，等.七种肿瘤相关自身抗体联合检测对肺癌的诊断价值[J].中国医药科学，2021，11（8）：37-40.
[16]	Gjerstorff MF，P pagenumber_ebook=24,pagenumber_book=18hl M，Olsen KE.Analysis of GAGE，NYESO-1 and SP17 cancer/testis antigen expression in early stage non-small cell lung carcinoma[J].BMC Cancer，2013，13：466.
[17]	Du Q，Yu R，Wang H，et al.Significance of tumor-associated autoantibodies in the early diagnosis of lung cancer[J].Clin Respir J，2018，12（6），2020-2028.
[18]	陈志，王玉红，朱卫东，等.联合检测7 种自身抗体在非小细胞肺癌中的诊断价值[J].临床与实验病理学杂志，2021，37（2）：182-185，191.
[19]	Dai L，Tsay JC，Li J，et al.Autoantibodies against tumorassociated antigens in the early detection of lung cancer[J].Lung Cancer，2016，99：172-179．
[20]	Ren S，Zhang S，Jiang T，et al.Early detection of lung cancer by using an autoantibody panel in Chinese population[J].Oncoimmunology，2018，7（2）：e1384108.