超声征象联合病理和生物学指标对乳腺浸润性导管癌脉管浸润的评估

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Abstract Objective To investigate the relationship between ultrasonic features, clinicopathological and biological indicators and lymphovascular invasion of invasive ductal breast carcinoma. Methods A total of 108 patients with invasive ductal breast carcinoma treated in the Department of Breast of Guangdong Second Traditional Chinese Medicine Hospital from January 2017 to April 2021 were selected retrospectively as the study subjects. They were divided into group with lymphovascular invasion (63 cases) and group without lymphovascular invasion (45 cases) according to the postoperative pathological results. The relationship between ultrasonic features, clinicopathological and biological indicators of invasive ductal breast carcinoma and lymphovascular invasion of invasive ductal breast carcinoma were analyzed. The value of four ultrasonic features of abnormal axillary lymph nodes in diagnosis of lymphovascular invasion in invasive ductal breast carcinom was also assessed. Results Univariate analysis of ultrasonic features showed that invasive ductal breast carcinomas showed more irregular shape, non-parallel orientation, internal microcalcification, posterior echo attenuation and abnormal axillary lymph nodes in the lymphovascular invasion group, with statistically significant differences (P<0.05). Multivariate logistic regression analysis showed that irregular morphology (β=2.093, OR=8.106, 95%CI=1.634-40.207) and abnormal axillary lymph nodes (β=2.509, OR=12.287, 95%CI=4.464-33.822) were independent risk factors for lymphovascular invasion in invasive ductal breast carcinoma respectively (P<0.05). Univariate analysis of clinicopathological and biological indicators showed that more proliferating cell nuclear antigen-67 (Ki-67) ≥20% and TNM stage 3 were found in the lymphovascular invasion group of invasive ductal breast carcinoma, with statistically significant differences (P<0.05). There were no statistically significant differences in the area under the ROC between the four features of ultrasonographic abnormal axillary lymph nodes and their combined diagnosis (P>0.05). Conclusion Irregular morphology of mass and abnormal axillary lymph nodes are independent risk factors for lymphovascular invasion in invasive ductal breast carcinoma respectively. Combined with clinicopathological and biological indicators, it is meaningful to assess lymphovascular invasion of invasive ductal breast carcinoma, and provides a useful basis for prognostic assessment and adjuvant treatment of breast cancer.

Key words： Ultrasonic features Invasive ductal breast carcinoma Lymphovascular invasion Abnormal axillary lymph nodes

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	CHEN Yanquan
	Li Jia
	Deng Minjun

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CHEN Yanquan,Li Jia,Deng Minjun. Evaluation of ultrasound signs combined with pathological and biological indexes for vascular infiltration of breast invasive ductal carcinoma[J]. 中国当代医药, 2022, 29(9): 27-31.

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https://www.dangdaiyiyao.com/EN/ OR https://www.dangdaiyiyao.com/EN/Y2022/V29/I9/27

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