糖皮质激素辅助阿奇霉素在儿童肺炎支原体感染性大叶性肺炎中的应用效果

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Abstract Objective To explore the application effect of glucocorticoid assisted Azithromycin in children with Mycoplasma pneumoniae infected lobar pneumonia. Methods A total of 80 children with mycoplasma-infected lobar pneumonia admitted to the Department of Pediatrics of Tongzhou District People′s Hospital of Nantong City from June 2019 to June 2021 were selected as the research objects. A random number table method was used to divide children into the experimental group and the control group, 40 cases in each group. Both groups were given basic treatment such as physical cooling or analgesia and fever, relieving asthma and resolving phlegm. The control group was given Azithromycin treatment, the experimental group was given glucocorticoid treatment on the basis of the control group.The clinical efficacy, antipyretic time, cough relief time, pulmonary rales disappearance time, hospitalization time, occurrence of adverse reactions after treatment were compared between the two group. The C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), procalcitonin (PCT) levels were compared between the two groups before and after treatment. Results The total effective rate of the experimental group was higher than that of the control group, and the difference was statistically significant (P<0.05). The cough relief time, hospitalization time, fever reduction time and lung rales disappearance time in the experimental group were all shorter than those in the control group, and the differences were statistically significant (P<0.05). There were no significant differences in the levels of CRP, ESR and PCT between the two groups before treatment (P>0.05). After treatment, the levels of CRP, ESR and PCT in the two groups were lower than those before treatment and the differences were statistically significant (P<0.05). And the CRP, ESR and PCT levels of the experimental group were lower than those of the control group, and the differences were statistically significant(P<0.05). The total incidence of adverse reactions in the experimental group was lower than that in the control group,and the difference was statistically significant (P>0.05).Conclusion Glucocorticoid assisted Azithromycin in the treatment of Mycoplasma pneumoniae infected lobar pneumonia in children can not only effectively regulate the immune function of children, reduce the release of inflammatory factors, shorten the treatment time and improve the curative effect, but also will not increase the adverse reactions in the treatment process, worthy of clinical application.

Key words： Azithromycin Methylprednisolone Sodium Succinate Mycoplasma pneumoniae Lobar pneumonia

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LI Xuejuan. Effect of glucocorticoid assisted Azithromycin in children with Mycoplasma pneumoniae infected lobar pneumonia[J]. 中国当代医药, 2022, 29(9): 23-26.

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https://www.dangdaiyiyao.com/EN/ OR https://www.dangdaiyiyao.com/EN/Y2022/V29/I9/23

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