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Quick Search     Adv Search 2022 Vol. 29, No. 7 Published: 2022-03-08   7 Application research of hypotonic Gastrography with dynamic contrastenhanced MSCT in preoperative TN staging of gastric cancer LIU Xiaohong; ZOU Nan′an; LI Zongliang ;ZENG Bingliang Objective To evaluate the predictive effect of dynamic enhanced MSCT dynamic enhancement scan of hypotonic gastrography (DCE-CT) on preoperative TN staging of gastric cancer (GC).Methods A total of 68 GC patients who were admitted to Pingxiang People′s Hospital from February 2020 In August,2021 for surgical treatment were selected.All patients received DCE-CT exa mination of hypozhangxia stomach before surgery,and the surgical results of all patients were used as the gold standard for comparison.The gold standard results of all GC patients were observed and analyzed.The clinical efficacy of DCE-CT in diagnosing T staging in GC patients compared with the gold standard results was observed;clinical efficacy of DCE-CT in diagnosing N staging in GC patients compared with gold standard results was observed.Results Compared with the gold standard results,the accuracy,sensitivity and specificity of DCE-CT in diagnosing T1 staging in GC patients were 100.0%,66.7% and 100.0% respectively.The accuracy,sensitivity and specificity of T2 staging were 69.2%,90.0% and 84.0% respectively.The accuracy,sensitivity and specificity of T3 staging were 85.7%,80.0% and 90.9% respectively.The accuracy,sensitivity and specificity of T4 diagnosis were 80.0%,66.7% and 96.7% respectively.Compared with the gold standard results,the accuracy,sensitivity and specificity of DCE-CT in diagnosing N0 staging in GC patients were 72.7%,88.9% and 88.5% respectively.The accuracy,sensitivity and specificity of N1 staging were 63.6%,70.0% and 85.2% respectively.The accuracy,sensitivity and specificity of N2 staging were 75.0%,37.5% and 96.8% respectively.The accuracy,sensitivity and specificity of N3 staging were 87.5%,100.0% and 96.3% respectively.Conclusion DCE-CT examination of low-tensor stomach in GC patients can accurately predict and evaluate preoperative T and N staging,so as to provide better reference and basis for clinical diagnosis and treatment. 2022 Vol. 29 (7): 7-10 [Abstract] ( 39 ) HTML (1 KB)  PDF (641 KB)  ( 17 ) 11 Study on hypoglycemic mechanism of Radix Puerariae based on network pharmacology SHU Jianzhong；LI Yinghui；PU Yuqing；LIU Qingling；ZHANG Juan；Gan Yuli； XIE Yongfang Objective To study the main active components and targets of Radix Puerariae in hypoglycemic action based on network pharmacology,analyze and find the pathway of Radix Puerariae to exert its pharmacodynamic effect and to understand its synergistic mechanism of multi-target and multi-pathway.Methods The related targets of Radix Puerariae were obtained by using the pharmacology database and analysis platform of traditional Chinese medicine system(TCMSP),and the related pathways and functional annotation information were obtained and analyzed by protein-protein interaction database platform and gene function analysis platform.By protein protein interaction networks and network analysis software "compounds-target-signal path-function" network to further determine the target features,through the molecular complex testing plug-ins,combined with its function and pathways for the clustering of proteinprotein interaction networks,different modules and each module of key genes.The binding of small molecular components of pueraria root and their targets was verified by molecular docking.Results Four components including formononetin,sitosterol,3′-methoxydaidzein,daidzein-4′,7-diglucoside were screened.Three main targets CYP17A1,NR3C1 and HTR2C were obtained.Conclusion Through the comprehensive analysis of target function,pathway and protein-protein interaction network,three target modules were obtained.By analyzing their possible mechanism of action in hypoglycemia and their research status,it can provide a certain basis for the efficient utilization of Radix Puerariae. 2022 Vol. 29 (7): 11-14转19 [Abstract] ( 55 ) HTML (1 KB)  PDF (1547 KB)  ( 75 ) 15 Determination of trace N-nitrosodimethylamine in Ranitidine and its preparation by liquid chromatography-electrostatic field orbitrap high resolution mass spectrometry WEI Zhixiong；LIU Dandan；LAN Mingxiong； WANG Kunpeng；LI Ru Objective To determine the content of N-nitrosodimethylamine (NDMA) in ranitidine and its preparations by liquid chromatography-electrostatic field orbitrap high resolution mass spectrometry (HPLC-Orbitrap HRMS).Methods The separation was performed on an ACE EXCEL 3 C18-AR(4.6 mm×100 mm,3 μm)column with mobile phase consisting of 0.1% formic acid in water and 0.1% formic acid in acetonitrile by gradient elution.The flow rate was 0.50 ml/min.The column temperature was 30℃,and the temperature of the injector was 4℃.The MS analysis was performed with ESI ion source in positive ion parallel reaction monitoring (PRM) scanning mode,and external standard method were used for quantification.Results NDMA with a good linear relationship in the range of 1-75 ng/ml (r=0.9990).The RSD of precision determination at the concentrations of 2 ng/ml and 20 ng/ml were 0.5% and 1.3% respectively,which were far less than 10%.The recoveries were 97.4%-105.2% with RSD of 2.5% (n=6).The limit of detection and limit of quantification were 0.03 ng/ml and 0.10 ng/ml,respectively.The established method was used to determine 7 batches of ranitidine active pharmaceutical ingredient (API) and ranitidine capsules.The results showed that the content of NDMA was among 0.12-2.36 ppm.Conclusion This method is specific,sensitive,accurate and simple,and can be applied to the determination of trace NDMA in ranitidine API and its preparations. 2022 Vol. 29 (7): 15-19 [Abstract] ( 39 ) HTML (1 KB)  PDF (991 KB)  ( 68 ) 20 The effect of Compound Glutamine Enteric-coated Capsules in adjuvant treatment of patients with ulcerative colitis and its influence on the rehabilitation of patients′ gastrointestinal function HUANG Jingyi；WANG Wei； JIANG Guohua Objective To study the clinical effect of Compound Glutamine Enteric-Coated Capsules on patients with ulcerative colitis (UC) and the rehabilitation effect on gastrointestinal function.Methods Ninety-two UC patients in the Department of Gastroenterology of Jiangmen Central Hospital from March 2018 to March 2021 were selected as the research objects,and they were divided into an experimental group (n=46) and a control group (n=46) by the random number table method.Patients in the experimental group were treated with Mesalamine+Compound glutamine entericcoated capsules,and patients in the control group were treated with Mesalamine.The treatment effect and the incidence of adverse reactions,the intestinal barrier function and gastrointestinal function rehabilitation indexes before and after treatment were compared between the two groups.Results The total effective rate of treatment in the experimental group (95.65%) was higher than that in the control group (82.61%),and the difference was statistically significant (P＜0.05).After treatment,the levels of diamine oxidase,D-lactic acid and bacterial endotoxin in the experimental group were lower than those in the control group,the differences were statistically significant (P＜0.05).The colonoscopy score and modified Mayo score (Mayo) in the experimental group were lower than those in the control group,and the gastrointestinal quality of life index (GIQLI) was higher than that in the control group,the differences were statistically significant (P＜0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion Compound Glutamine Enteric-Coated Capsules combined with Mesalazine in the treatment of ulcerative colitis can effectively improve the therapeutic effect of patients without good safety.It has a good effect on improving the intestinal barrier function of patients with ulcerative colitis,inhibiting the progress of intestinal mucosa,reducing the disease-related impact of patients,and optimizing the quality of life related to gastrointestinal system.It has a positive value in promoting the rehabilitation of gastrointestinal function in patients with ulcerative colitis. 2022 Vol. 29 (7): 20-23 [Abstract] ( 38 ) HTML (1 KB)  PDF (588 KB)  ( 37 ) 24 Clinical effect of Recombinant Human Brain Natriuretic Peptide combined with Milrinone in the treatment of senile congestive heart failure LIU Yan Objective To investigate the clinical effect of Recombinant Human Brain Natriuretic Peptide combined with Milrinone in the treatment of senile congestive heart failure.Methods A total of 90 elderly patients with congestive heart failure admitted to the Second Affiliated Hospital of Shenyang Medical College from February 2019 to March 2021 were selected as the study subjects.According to the random number table method,they were divided into the control group (45 cases) and the observation group (45 cases).The control group was treated with Milrinone,and the observation group was treated with Recombinant Human Brain Natriuretic Peptide combined with Milrinone.Treatment effect,cardiac function and Minnesota quality of life scale (MLHFQ) scores were compared between two groups.Results The total effective rate of observation group was higher than that in the control group,the difference was statistically significant (P＜0.05).There were no significant differences in cardiac function indexes between the two groups before treatment (P＞0.05).After treatment,the left ventricular ejection fraction (LVEF),stroke volume (SV) and cardiac output (CO) in two groups were higher than those before treatment,and the observation group was higher than that in the control group,the differences were statistically significant (P＜0.05).There were no significant differences in left ventricular hypertrophy indexes between the two groups before treatment (P＞0.05).After treatment,the thickness of ventricular septum (IVST),left ventricular posterior wall (LVPWT) and left ventricular end diastolic diameter (LVDD) in two groups were lower than those before treatment,and the observation group was lower than that in the control group,the differences were statistically significant (P＜0.05).Before treatment,there was no significant difference in MLHFQ score between two groups (P＞0.05).After treatment,the MLHFQ scores of the two groups were higher than those before treatment,and the observation group was higher than the that in control group,the differences were statistically significant(P＜0.05).Conclusion In clinical treatment of senile congestive heart failure,the combination of Recombinant Human Brain Natriuretic Peptide and Milrinone can improve the cardiac function,left ventricular hypertrophy index and MLHFQ score more obviously,and the curative effect is better. 2022 Vol. 29 (7): 24-27 [Abstract] ( 38 ) HTML (1 KB)  PDF (588 KB)  ( 28 ) 28 Textual research on Materia Medica of Sinapis Semen WU Yuqiang；DAI Zhonghua；CHEN Xiaoyi；LUO Yudong Sinapis Semen is a traditional Chinese medicinal herb in China.It has the effects of warming the lungs,eliminating phlegm and promoting qi,dispelling masses and unblocking collaterals and relieving pain.It is a traditional Chinese medicinal herb with a long history of medicinal use.However,due to differences in the names and sourcess in the past dynasties,it has caused some interference in clinical medication.In order to solve the problem of base source confusion of Sinapis Semen,this paper summarizes the name,base source,nature,and effect of Sinapis Semen based on previous herbal works and modern research data.Through textual research,it is inferred that the nature,taste,efficacy,flower color,origin,character and base source of Sinapis Semen used in ancient and modern times are consistent.They are all dried and mature seeds of Sinapis alba L.in Cruciferae family. 2022 Vol. 29 (7): 28-30转35 [Abstract] ( 50 ) HTML (1 KB)  PDF (483 KB)  ( 45 ) 31 Application of virtual touch tissue quantification technique in evaluating kidney elasticity in chronic kidney disease PU Lei ；SUN Jianwei Chronic kidney disease (CKD) is the common outcome of all kinds of kidney disease p-rogression,chronic kidney disease once formed,often progress at different rates,so early diagnosis and timely treatment is particularly important,can delay the disease progression,improve the quality of life of patients.Virtual touch tissue quantification(VTQ) technology can quantitatively reflect the elasticity of tissues,even in the case of insignificant morphological changes,it can also assess the elasticity of diseased tissues,thus reflecting the extent and progression of lesions,and improve the accuracy of the diagnosis of diseases involving fibrosis.At present,VTQ technology has been applied in the clinical evaluation of normal kidney,acute kidney disease,chronic kidney disease,kidney transplantation and many other diseases.This article mainly reviews the application status of VTQ in chronic kidney disease. 2022 Vol. 29 (7): 31-35 [Abstract] ( 35 ) HTML (1 KB)  PDF (468 KB)  ( 27 ) 36 Predictive value of diaphragmatic quantitative parameters under critical ultrasound for weaning outcomes in ICU patients undergoing mechanical ventilation LIU Jiang；LIU Lijiang；YANG Huaping Objective To explore the predictive value of diaphragmatic quantitative parameters under critical ultrasound for weaning outcomes in patients undergoing mechanical ventilation in intensive care unit (ICU).Methods A retrospective analysis was performed on the clinical baseline data of 82 patients undergoing mechanical ventilation in ICU of Pingxiang Mining Group Co.,Ltd.between March 2018 and May 2020.According to weaning outcomes,they were divided into weaning success group (n=63) and weaning failure group (n=19).All underwent examinations by color ultrasound diagnostic system.The diaphragmatic quantitative parameters were compared between the two groups.The predictive value of diaphragmatic quantitative parameters for weaning outcomes in ICU patients undergoing mechanical ventilation was evaluated by ROC curves.Results Ultrasonic examination showed that diaphragm excursion (DE),diaphragmatic thickness at the end of expiration (DTee),diaphragmatic thickness at the end of inspiration (DTei) and diaphragm thickening fraction (DTF) in weaning success group were significantly higher than those in weaning failure group,the differences were statistically significant (P＜0.05).ROC curve analysis showed that AUC values of DE,DTee,DTei,DTF and combined test for predicting weaning failure were 0.871,0.833,0.805,0.883 and 0.979,respectively,the differences were statistically significant (P＜0.05).Conclusion The predictive value of diaphragmatic quantitative parameters is high for weaning outcomes in ICU patients undergoing mechanical ventilation. 2022 Vol. 29 (7): 36-38 [Abstract] ( 41 ) HTML (1 KB)  PDF (531 KB)  ( 33 ) 39 Application of percutaneous tracheotomy and traditional tracheotomy in critically ill patients YAN Yinzong Objective To compare the application effect of percutaneous tracheotomy and traditional tracheotomy in critically ill patients.Methods A total of 60 critically ill patients who underwent tracheostomy treatment at People′s Hospital of Yunfu City from June 2020 to August 2021 were selected as the research objects.According to random number table method,they were divided into treatment group and control group,with 30 cases in each group.The control group was treated with traditional tracheotomy,and the treatment group was treated with percutaneous tracheotomy.The diameter of the surgical incision,intraoperative blood loss,operative time and extubation of the two groups were recorded and compared.Perioperative indicators such as the healing time of the posterior surgical incision,the incidence of complications and mortality of the two groups of patients after different treatments were counted.Results There were no statistically significant differences in the surgical incision diameter and operation time between the two groups (P＞0.05).The intraoperative blood loss of the treatment group was less than that of the control group,and the postoperative healing time after extubation was shorter than that of the control group,the total complication rate was 10.00% (3/30),lower than 23.33% (7/30) of the control group,the mortality rate was 3.33% (1/30),lower than 13.33%(4/30) of the control group,the differences were statistically significant (P＜0.05).Conclusion Compared with traditional tracheotomy,the use of percutaneous tracheotomy can effectively reduce the amount of intraoperative blood loss in patients.Percutaneous tracheotomy can achieve rapid healing of the surgical incision after extubation,and under this operation,patients are not likely to have related complications,the mortality rate is lower,and the prognosis is better.Percutaneous tracheotomy has higher clinical application value. 2022 Vol. 29 (7): 39-41转45 [Abstract] ( 38 ) HTML (1 KB)  PDF (504 KB)  ( 34 ) 42 Clinical features and risk factors of pulmonary tuberculosis complicated by fungal infection ZHANG Haiyan；ZHANG Cai；FAN Hui Objective To investigate the clinical characteristics and risk factors of pulmonary tuberculosis complicated by fungal infection.Methods The clinical data of 104 pulmonary tuberculosis patients admitted to Rugao Hospital Affiliated to Nantong University from January 2017 to December 2020 were retrospectively analyzed.All the selected subjects were cultured with Aspergillus,and the patients were divided into infection group (n=25) and non-infected group (n=79) according to the culture results.The clinical data of the two groups were counted,the clinical characteristics and risk factors of fungal infection were analysed.Results The results of Aspergillus culture showed that of the 104 pulmonary tuberculosis patients,25 cases had fungal infection,the incidence was 24.04% (25/104).The most common clinical manifestations of 25 pulmonary tuberculosis patients with fungal infection were cough and sputum (100.00%),followed by hemoptysis (72.00%),fever (36.00%),chest pain (16.00%),dyspnea (4.00%).The proportion of hospitalization times＞2 times,repeated application of broad-spectrum antibiotics,long-term application of glucocorticoid and chronic obstructive pulmonary disease in the infection group were higher than those in the non infection group,the differences were statistically significant (P＜0.05).There were no statistically significant differences between the two groups in gender,age,body weight,smoking history and diabetes (P＞0.05).Logistic multivariate regression analysis showed that proportion of hospitalizations ＞2 times (β=1.626,OR =5.083,95% CI =1.951 -13.242),repeated use of broad-spectrum antibiotics (β=2.026, OR=7.585,95%CI=2.814-20.444),long-term use of glucocorticoids (β=1.357, OR=3.886,95%CI=1.519-9.942),combined with chronic obstructive pulmonary disease (β=2.094, OR=8.120,95%CI=2.945-22.387) were independent risk factors for pulmonary tuberculosis complicated with fungal infection.Conclusion The proportion of hospitalizations＞2 times,repeated use of broad-spectrum antibiotics,long-term use of corticosteroids,and chronic obstructive pulmonary tuberculosis patients are more likely to be infected with fungal.The clinical needs of patients with high-risk factors need to be paid close attention to in order to improve the prognosis. 2022 Vol. 29 (7): 42-45 [Abstract] ( 40 ) HTML (1 KB)  PDF (495 KB)  ( 23 ) 46 Effect comparison of different fixation methods of venous indwelling needle during labor WANG Dan；YIN Na ；XIAO Wenping；LIU Guirong Objective To compare the effect of different fixation methods of venous indwelling needle during labor.Methods A total of 80 cases of parturient women admitted to Ganzhou Maternal and Child Health Hospital from June to December 2020 were selected as the research objects.They were divided into observation group and control group by random number table method,with 40 cases in each group.The observation group was fixed with "watchband" fixation,while the control group was fixed with multi-loop winding.The total incidence of adverse events and the total satisfaction rate of intravenous indwelling needle fixation were compared between the two groups.Results The total incidence of adverse events in the observation group (7.5%) was lower than that in the control group (30.0%),the difference was statistically significant (P＜0.05).The total satisfaction rate of intravenous indwelling needle fixation in the observation group (97.5%) was higher than that in the control group (82.5%),and the difference was statistically significant (P＜0.05).Conclusion During labor,the effect of "watchband" fixation of intravenous indwelling needle is better than that of multi-loop winding fixation,which reduces the occurrence of adverse events and improves the satisfaction of puerpera. 2022 Vol. 29 (7): 46-48 [Abstract] ( 39 ) HTML (1 KB)  PDF (484 KB)  ( 36 ) 49 Effect of Tovastaptan assisted with Berprost Sodium in patients with heart failure caused by pulmonary hypertension ZHU Baocheng；ZHANG Jiaxiu Objective To investigate the effect of Tovastaptan assisted with Berprost Sodium in patients with heart failure caused by pulmonary hypertension.Methods A total of 60 patients with heart failure caused by pulmonary hypertension admitted to Jiujiang First People′s Hospital from June 2020 to January 2021 were selected as the research subjects,and they were divided into control group (30 cases) and research group (30 cases) according to random throwing method.The control group was treated with basic treatment combined with Beprost Sodium,and the study group was treated with Tovaptan on the basis of the control group.Blood sodium,blood potassium,endocrine factors,serum creatinine and adverse reactions were compared between the two groups.Results The disappearance time of edema,relief time of shortness of breath and improvement time of fatigue in the observation group were shorter than those in the control group,and the differences were statistically significant (P＜0.05).Before treatment,there was no significant difference in serum potassium,creatinine and sodium between the two groups (P＞0.05).After treatment,the serum potassium and sodium levels of the two groups were higher than those before treatment,and the serum creatinine was lower than before treatment,and the serum creatinine of the observation group was lower than that of the control group,and the serum sodium and potassium levels were higher than those of the control group,the differences were statistically significant (P＜0.05).There was no significant difference in the total incidence of adverse reactions between the two groups (P＞0.05).Before treatment,there were no significant differences in left ventricular ejection fraction (LVEF) and N-terminal pro brain natriuretic peptide (NT-proBNP) between the two groups (P＞0.05).After treatment,LVEF levels of the two groups were higher than before treatment,NT-proBNP were lower than before treatment,and NT-proBNP of the observation group was lower than that of the control group,LVEF level was higher than that of the control group,the difference was statistically significant (P＜0.05).Conclusion Tovastan combined with Berprost Sodium can effectively improve cardiac function,improve symptom relief time,no serious adverse reactions,and gradually return to normal biochemical indicators in patients with pulmonary hypertension heart failure. 2022 Vol. 29 (7): 49-52 [Abstract] ( 30 ) HTML (1 KB)  PDF (421 KB)  ( 25 ) 53 Clinical effect and safety of Nicorandil in the treatment of unstable angina pectoris of coronary heart disease JIANG Ling；WU Yuxian； SHEN Xuebin Objective To explore the clinical efficacy and safety of Nicorandil in patients with unstable angina pectoris of coronary heart disease.Methods From October 2019 to September 2020,82 patients with unstable angina of coronary heart disease in Nanping First Hospital were selected as the research objects,and they were divided into a control group and a study group (with 41 cases each) using the random number table method.Patients in the control group were treated with conventional treatment,and patients in the study group were treated with Nicorandil on the basis of the control group.The clinical efficacy,the number and duration of angina pectoris,the incidence of adverse reactions,and the incidence of adverse cardiovascular events were compared between the two groups of patients.Results The total effective rate of treatment in the study group was higher than that in the control group,the difference was statistically significant (P＜0.05).There was no significant difference in the number and duration of angina pectoris before treatment between the two groups (P＞0.05).The number and duration of angina pectoris after treatment in the two groups were lower than those before treatment,the number and duration of angina pectoris in the study group after treatment were lower than those in the control group,and the differences were statistically significant (P＜0.05).There were no significant difference in the incidence of diarrhea,nausea,vomiting,headache and other adverse reactions between the two groups (P＞0.05),and all the adverse reactions were relieved after symptomatic treatment.There was no significant difference in the incidence of adverse cardiovascular events between the two groups (P＞0.05).Conclusion Nicorandil treatment for patients with unstable angina pectoris of coronary heart disease can significantly improve the symptoms of chest tightness,chest pain,fatigue and other symptoms,relieve the onset of angina pectoris,improve myocardial ischemia,and exert significant clinical effects. 2022 Vol. 29 (7): 53-56 [Abstract] ( 36 ) HTML (1 KB)  PDF (440 KB)  ( 123 ) 57 Therapeutic effect of low-dose Olanzapine combined with Venlafaxine on patients with acute major depression SUN Yan；LIN Dongmei； Objective To investigate the therapeutic effect of low-dose Olanzapine combined with Venlafaxine on acute phase of patients with acute major depression.Methods A total of 94 patients with acute major depression admitted to the Fourth People′s Hospital of Yingkou City from May 2019 to May 2020 were selected as the research subjects.They were divided into study group and reference group by random number table method,with 47 patients in each group.The reference group was treated with Venlafaxine orally,while the study group was treated with low-dose Olanzapine on the basis of Venlafaxine.The Hamilton depression scale (HAMD) scores before treatment and at 2,4,8 and 16 weeks after treatment of the two groups were compared,the clinical efficacy and total incidence of adverse reactions in the two groups were compared.Results Before treatment,there were no significant differences in HAMD scores between the two groups (P＞0.05).HAMD scores of 2,4,8 and 16 weeks after treatment in the two groups were lower than those before treatment,the differences were statistically significant (P＜0.05).The HAMD scores at 2,4,8 and 16 weeks after treatment of the study group were lower than those of the reference group,with statistical significances (P＜0.05).The total effective rate of study group was higher than that of reference group,and the difference was statistically significant(P＜0.05).There was no significant difference in the total incidence of adverse reactions between the two groups (P＞0.05).Conclusion The combination of Venlafaxine and low-dose Olanzapine in the treatment of patients with acute major depression can improve the clinical treatment effect and help to control depressive symptoms more quickly without increasing adverse reactions 2022 Vol. 29 (7): 57-59转63 [Abstract] ( 47 ) HTML (1 KB)  PDF (839 KB)  ( 34 ) 60 Application effect of Risperidone in patients with schizophrenia WANG Tianming；JIANG Xiaojian；HUANG Deqiang Objective To explore the application effect of Risperidone in patients with schizophrenia.Methods From January 2020 to December 2020,78 patients with schizophrenia admitted to Ruijin Ankang Hospital were selected.According to the random number table method,they were divided into the observation group (39 cases) and the control group (39 cases).The observation group was given Risperidone treatment,and the control group was given Olanzapine treatment.The course of treatment were twevel weeks.The levels of serum brain-derived neurotrophic factor (BDNF),insulin-like growth factor-2 (IGF-2),interleukin-13 (IL-13) and the scores of social function assessment scale (SSFPI),intelligent mental state examination scale (MMSE),positive and negative symptom scale (PANSS) were compared between the two groups before and after treatment.The efficacy and adverse drug reactions of the two groups were observed.Results The levels of serum BDNF,IGF-2 and IL-13 in the two groups after treatment were significantly higher than those in the same group before treatment,the differences were statistically significant (P＜0.05).The levels of serum BDNF and IGF-2 in the observation group were higher than those in the control group,the differences were statistically significant (P＜0.05).There was no significant difference in the level of serum IL-13 between the two groups after treatment (P＞0.05).The SSFPI and MMSE scores of the two groups after treatment were higher than those of the same group before treatment,while the PANSS score of the two groups after treatment were lower than those of the same group before treatment,the differences were statistically significant (P＜0.001).After treatment,the SSFPI and MMSE scores of the observation group were higher than those of the control group,while the PANSS scores of the observation group was lower than that of the control group,the differences were statistically significant (P＜0.05).There was no significant difference in the clinical effective rate between the two groups (P＞0.05).There was no significant difference in the incidence of adverse reactions between the two groups (P＞0.05).Conclusion Risperidone is effective in the treatment of schizophrenia.Compared with Olanzapine,Risperidone has fewer clinical adverse reactions,which is more conducive to the improvement of clinical symptoms,the improvement of serum indexes and the recovery of social function. 2022 Vol. 29 (7): 60-63 [Abstract] ( 43 ) HTML (1 KB)  PDF (484 KB)  ( 19 ) 64 Effect of Edaravone on serum BNP,CRP and Hcy levels in patients with acute cerebral infarction ZENG Qing；LI Xiaolian Objective To explore the application effect of Edaravone in patients with acute cerebral infarction (ACI).Methods A total of 64 ACI patients admitted to the Second People′s Hospital of Yichun City from September 2019 to March 2021 were selected as the study subjects,and they were divided into study group and control group according to random number table method,with 32 patients in each group.The control group received Aspirin routine treatment,the study group plus Edaravone treatment.The clinical efficacy,serological indexes,degree of neurological deficit and adverse reactions were compared between the two groups.Results The total effective rate of the study group was higher than that of the control group,the difference was statistically significant (P＜0.05).Before treatment,there were no significant differences in the levels of brain natriuretic peptide (BNP),C-reactive protein (CRP) and homocysteine (Hcy)between two groups (P＞0.05).After treatment,the levels of BNP,CRP and Hcy in the study group were lower than those in the control group,and the differences were statistically significant (P＜0.05).Before treatment,there was no significant difference in the scores of National Institutes of Health stroke scale (NIHSS) between the two groups (P＞0.05).After treatment,NIHSS score of the study group was lower than that of the control group,and the difference was statistically significant (P＜0.05).There was no significant difference in the total incidence of adverse reactions between the two groups (P＞0.05).Conclusion Edaravone can effectively improve the levels of serum BNP,CRP and Hcy in patients with acute cerebral infarction,reduce inflammatory reaction and facilitate the recovery of neurological function. 2022 Vol. 29 (7): 64-66转70 [Abstract] ( 40 ) HTML (1 KB)  PDF (503 KB)  ( 25 ) 67 Investigation of the status quo of depression after ischemic stroke and the application value of NIHSS score in determining the risk of post-stroke depression TANG Yan； YIN Wen Objective To investigate the incidence of ischemic post-stroke depression (PSD) and the value of National Institutes of Health stroke scale (NIHSS) score in evaluating PSD.Methods The clinical data of 120 patients with ischemic stroke admitted to Shuyang Hospital Affiliated to Xuzhou Medical University from June 2019 to December 2020 were retrospectively analyzed.According to the occurrence of PSD,they were divided into the PSD group and the non-PSD group.The pathological data of the two groups were compared,and the relationship between the occurrence of PSD and pathological conditions was analyzed.The changes of Hamilton depression scale (HAMD) and NIHSS scores in the two groups were observed. Pearson linear correlation analysis was used to analyze the correlation between NIHSS score and HAMD factor score and total score,and the predictive value of NIHSS score on PSD was analyzed by receiver operating characteristic curve (ROC).Results Of 120 patients with ischemic stroke,42 cases (35.00%) had PSD and 78 cases (65.00%) had no PSD.The scores of anxiety/somatization,day and night change,sleep disorder,sense of despair,cognitive disorder and total score of HAMD in the PSD group were higher than those in the non-PSD group,the NIHSS score in the PSD group was higher than that in the non-PSD group,the differences were statistically significant (P＜0.05). Pearson linear correlation analysis showed that NIHSS score was positively correlated with anxiety/somatization,day and night changes,sleep disorder,despair,cognitive impairment score and total HAMD score (r=5.412,4.726,4.925,5.048,5.194,6.795,all P＜0.05).NIHSS score predicted the area under the curve of PSD was 0.640 (standard error=0.051, P=0.008,95%CI=0.541-0.739).When NIHSS score ＞7.310 points,ischemic stroke patients had a higher risk of PSD.Conclusion The incidence of PSD is higher after ischemic stroke.NIHSS score is positively correlated with HAMD factor score and total score,and has certain predictive value for PSD. 2022 Vol. 29 (7): 67-70 [Abstract] ( 34 ) HTML (1 KB)  PDF (514 KB)  ( 30 ) 71 Application effect of different vascular access in hemodialysis patients WANG Manting Objective To explore the application effect of different vascular pathways in hemodialysis patients.Meth-ods A total of 90 hemodialysis patients from the First People′s Hospital of Jiujiang City from June 2017 to December 2020 were selected as the research objects,and they were divided into group A (45 cases) and group B (45 cases) by random number table method.Long-term catheter was used in group B,and autologous arteriovenous fistula was used in group B.The treatment effect,inflammatory factor levels,total protein,albumin,Kt/V and hemoglobin levels,complication rate and vascular patency rate were compared between the two groups.Results There was no significant difference in the total effective rate between the two groups (P＞0.05).Before treatment,there was no significant difference in the levels of interleukin-6 (IL-6) and C-reactive protein (CRP) between the two groups (P＞0.05).After treatment,the levels of IL-6 and CRP in group A were higher than those in group B,the difference was statistically significant (P＜0.05).After treatment,there were no significant differences in total protein,albumin,the ratio of urea clearance to volume by dialyzer (Kt/V) and hemoglobin levels within a certain dialysis time (P＞0.05).After treatment,the total incidence of complications in group A was higher than that in group B,and the difference was statistically significant (P＜0.05).After treatment,the vascular patency rate of group A was lower than that of group B,and the difference was statistically significant (P＜0.05).Conclusion Both long-term catheters and autogenous arteriovenous fistulas have significant therapeutic effects in hemodialysis.Both vascular access methods can help improve the patient′s hemoglobin level,but autogenous arteriovenous fistulas have more obvious effects in improving inflammation and can Minimizing the incidence of complications is worthy of clinical adoption and promotion. 2022 Vol. 29 (7): 71-73转77 [Abstract] ( 27 ) HTML (1 KB)  PDF (424 KB)  ( 25 ) 74 Effect of retroperitoneal laparoscopic adrenalectomy for adrenal incidental tumor LI Feng Objective To study the effect of retroperitoneal laparoscopic adrenalectomy for adrenal incidental tumor.Methods A total of 60 patients with adrenal incidental tumor admitted to the Second Affiliated Hospital of Guangzhou Medical University from January 2015 to January 2021 were selected as the subjects.They were divided into study group 1 and study group 2 by random number table method,with 30 patients in each group.The study group 1 was treated with retroperitoneal laparoscopic adrenalectomy,and the study group 2 was treated with transabdominal laparoscopic adrenalectomy.The surgical indicators,complications and quality of life were compared between the two groups.Results The operation time,postoperative feeding time,off-bed activity time and hospital stays in the study group 1 were shorter than those in the study group 2,and the differences were statistically significant (P＜0.05).The intraoperative blood loss in study group 1 was less than that in study group 2,and the difference was statistically significant (P＜0.05).The total incidence of complications in study group 1 was lower than that in study group 2,and the difference was statistically significant (P＜0.05).There was no statistically significant difference in preoperative quality of life(QOL) score between the two groups (P＞0.05).All postoperative QOL scores in study group 1 were higher than those in study group 2,and the differences were statistically significant (P＜0.05).Conclusion The retroperitoneal laparoscopic adrenalectomy can reduce the operation time,bleeding volume,hospital stays and surgical complications,and improve the treatment safety and quality of life.It is worthy of application and promotion. 2022 Vol. 29 (7): 74-77 [Abstract] ( 40 ) HTML (1 KB)  PDF (411 KB)  ( 15 ) 78 Effect of Xiaojin Pills combined with Xiakucao Capsules in the treatment of Hashimoto thyroiditis with nodules and its influence on inflammatory factors ZHANG Wei；ZHANG Minghai；HU Jun Objective To investigate the effect of Xiaojin Pills combined with Xiakucao Capsules in the treatment of Hashimoto thyroiditis with nodules and its influence on inflammatory factors.Methods A total of 60 patients with Hashimoto thyroiditis with nodules who were admitted to the Third Affiliated Hospital of Gannan Medical College from May 2018 to June 2020 were selected as the research subjects.They were divided into the control group (n=30) and the study group (n=30) according to random number table method.The patients in control group were treated with Levothyroxine Sodium tablets,and the patients in the study group were treated with Xiaojin Pills and Xiakucao Capsules on the basis of the control group.The course of treatment lasted 12 weeks,for two consecutive courses.The thyroid volume and thyroid nodule size,thyroid function indexes,inflammatory factor levels before treatment and at 12 and 24 weeks of treatment,and adverse reactions between the two groups were compared.Results The thyroid volume and the diameter of thyroid nodules in the study group after 12 and 24 weeks of treatment were smaller than those in the control group,and the differences were statistically significant (P＜0.05).The levels of serum antithyroid peroxidase antibody (TPOAb),anti-thyroglobulin antibody (TG-Ab),thyroid stimulating hormone (TSH),γ-interferon (IFN-γ) and interleukin-2(IL-2) in the study group after 12 and 24 weeks of treatment were lower than those in the control group,with statistical significances (P＜0.05).The level of serum interleukin-10(IL-10) of patients in the study group after 12 and 24 weeks of treatment were higher than those in the control group,and the differences were statistically significant (P＜0.05).During the treatment period,the total incidence of adverse reactions in the study group was 3.33%,which was lower than that of the control group accounting for 23.33%,with statistical significance (P＜0.05).There were no significant differences in the thyroid volume,thyroid nodule diameter,and serum levels of TPO-Ab,TG-Ab,TSH,IFN-γ,IL-2,and IL-10 before treatment (P＞0.05).Conclusion Xiaojin Pills combined with Xiakucao Capsules can reduce the thyroid volume and nodule size in patients with Hashimoto thyroiditis with nodules,improve the level of thyroid antibodies,enhance thyroid function,inhibit inflammation,and have few adverse reactions. 2022 Vol. 29 (7): 78-81 [Abstract] ( 40 ) HTML (1 KB)  PDF (495 KB)  ( 31 ) 82 Efficacy analysis of Methimazole and Propylthiouracil in the treatment of diffuse toxic goiter complicated with Hashimoto hyperthyroidism LIN Hanying Objective To investigate the efficacy of Methimazole and Propylthiouracil in the treatment of diffuse toxic goiter (Graves disease) complicated with Hashimoto hyperthyroidism and their influence on thyroid peroxidase antibody(TPOAb),thyroglobulin antibody (TgAb) and thyrotropin receptor antibody (TRAb).Methods A total of 98 patients with Graves disease complicated with Hashimoto hyperthyroidism treated in the Endocrine Clinic of the First People′s Hospital of Zhaoqing City from September 2018 to August 2019 were selected as the research objects.They were divided into the observation group (49 cases) and the control group (49 cases) according to random number table method.The observation group was treated with Methimazole,and the control group was treated with Propylthiouracil.The clinical efficacy,the changes of TPOAb,TGAb and TRAb indexes and the total incidence of adverse reactions were observed in the two groups.Results After treatment,the levels of TPOAb,TgAb,TRAb,free triiodothyrine (FT3),free thyroid hormone (FT4) in the two groups were lower than those before treatment,the proportions of hypermetabolic symptom reduction and thyroid stimulating hormone (TSH) in the two groups were higher than those before treatment,the levels of TPOAb,TgAb,TRAb,FT3,FT4 in the observation group were lower than those in the control group,the proportions of hypermetabolic symptom reduction and TSH in the observation group was higher than that in the control group,and the differences were statistically significant (P＜0.05).The total incidence of adverse reactions after treatment in the observation group was significantly lower than that in the control group,and the difference was statistically significant (P＜0.05).Conclusion For the treatment of Graves disease complicated with Hashimoto hyperthyroidism,Propylthiouracil and Methimazole can play a better therapeutic effect.Among them,Methimazole has a better therapeutic effect than Propylthiouracil,with less adverse reactions and high safety,which is worthy of wide clinical promotion. 2022 Vol. 29 (7): 82-85 [Abstract] ( 45 ) HTML (1 KB)  PDF (530 KB)  ( 33 ) 86 Distribution and drug resistance analysis of pathogens in patients with diabetic foot ulcer ZHOU Lili ；ZHOU Yan； WANG Yunlin Objective To investigate the distribution and drug resistance of pathogens in patients with diabetic ulcer foot (DUF).Methods A total of 134 cases of DUF patients admitted to Foshan Second People′s Hospital from January 2018 to December 2019 were selected as the research objects.The samples were collected for bacterial culture and drug sensitivity test,and the distribution of pathogens and drug sensitivity test results of DUF patients were analyzed.Results A total of 142 strains of pathogenic bacteria were detected in 134 samples,included 67 strains of Gram-positive bacteria,59 strains of Gram-negative bacteria and 16 strains of fungi.The sensitivity rate of Staphylococcus aureus to Tigecycline,Linezolid and Vancomycin were 100.00%,and the sensitivity rate to Carbapenems and Aminoglycosides represented by Ertapenem were 70%.The sensitivity rate of Enterococcus faecalis to Tigecycline,Linezolid,Vancomycin and Carbapenems and Aminoglycosides represented by Ertapenem were 60%.The sensitivity rate of Escherichia coli to Ertapenem was 100.00%,and that to Piperacillin Tazobactam,Gentamicin and Amikacin were more than 60%.The sensitivity rate of Klebsiella pneumoniae to Ertapenem,Aztreonam,Amikacin,Gentamicin,Levofloxacin,Ciprofloxacin,Moxifloxacin and Cefazoxime were more than 75%,and that to Piperacillin Tazobactam and Cefoperazone Sulbactam were more than 65%.The sensitivity rate of Pseudomonas aeruginosa to Piperacillin Tazobactam was only more than 60%.Conclusion Gram-positive bacteria and Gram-negative bacteria are the main pathogens of DUF.There are obvious differences in drug resistance between them.Clinically,it is necessary to detect the changes of bacterial drug resistance and use antibiotics reasonably according to the test results. 2022 Vol. 29 (7): 86-88转92 [Abstract] ( 36 ) HTML (1 KB)  PDF (536 KB)  ( 34 ) 89 Clinical effect of Calcitriol in the treatment of Hashimoto thyroiditis SUN Chuang Objective To explore the clinical effect of Calcitriol in the treatment of Hashimoto thyroiditis.Methods A total of 110 patients with Hashimoto thyroiditis treared in Xincheng Hospital of Liaoyang Central Hospital selected from January 2019 to January 2021 were selected and divided into the control group and the observation group according to random number table method,with 55 cases in each group.The control group was treated with Levothyroxine Tablets,and the observation group was treated with Calcitriol on the basis of the control group.The clinical efficacy,thyroid hormone indexes,concentration of anti-thyroglobulin antibody (TGAb) and anti-thyroid peroxidase antibody (TPOAb)before and after treatment were compared between the two groups,and the adverse reactions during treatment were observed.Results The total clinical effective rate of the observation group was higher than that of the control group,the difference was statistically significant (P＜0.05).The levels of free triiodothyronine (FT3) and free thyroxine (FT4) in the observation group after treatment were higher than those in the control group,and the levels of thyroid stimulating hormone (TSH),TGAb and TPOAb in the observation group after treatment were lower than those in the control group,the differences were statistically significant (P＜0.05).During the treatment period,there were no adverse reactions such as blood routine,urine routine,liver and kidney function index lesions in the two groups.Conclusion The addition of Calcitriol on the basis of Levothyroxine Tablets in the treatment of Hashimoto thyroiditis can achieve significant clinical effects,can promote the improvement of thyroid hormone levels,adjust the concentration of TGAb and TPOAb,and there is no obvious adverse reaction during the treatment period,with high safety. 2022 Vol. 29 (7): 89-92 [Abstract] ( 32 ) HTML (1 KB)  PDF (525 KB)  ( 25 ) 93 Effect of Ketorolac Tromethamine assisted brachial plexus block with Ropivacaine in radial and ulnar surgery in children LAI Jianhong；LONG Yan；ZENG Fanying Objective To investigate the effect of Ketorolac Tromethamine assisted Ropivacaine brachial plexus block in children′s radius and ulna surgery.Methods A total of 106 children with radiulnar fracture admitted to Ganzhou Hospital of Traditional Chinese Medicine from June 2018 to June 2021 were selected as the study subjects,and randomly divided into observation group (n=53) and control group (n=53) by drawing lots.Both groups were treated with reduction and fixation of radioulnar fracture.The control group received brachial plexus block anesthesia with Ropivacaine,and the observation group was assisted with Ketorolac Tromethamine on the basis of the control group.The hemodynamic indexes,postoperative analgesic effect,stress response index level,quality of life score and the total incidence of adverse reactions were compared between the two groups.Results The mean arterial pressure,heart rate and blood oxygen saturation in observation group were higher than those in control group,the differences were statistically significant (P＜0.05).At 2,6,12 and 24 h postoperatively,the visual analogue scores of the observation group were lower than those of the control group,the differences were statistically significant (P＜0.05).The levels of C-reactive protein,cortisol and norepinephrine in observation group at 24 h after operation were lower than those in control group,the differences were statistically significant (P＜0.05).The scores of postoperative quality of life in the observation group were higher than those in the control group,the differences were statistically significant (P＜0.05).The total incidence of adr in the observation group was lower than that in the control group,and the difference was statistically significant (P＜0.05).Conclusion Ketorolac Tromethamine assisted brachial plexus block with Ropivacaine has a good effect in children′s radial and ulnar surgery,which can maintain the stable state of blood pressure,heart rate and oxygen saturation,reduce postoperative pain,improve stress response,and improve the quality of life of children,with good safety,which can be recommended in clinical practice. 2022 Vol. 29 (7): 93-97 [Abstract] ( 34 ) HTML (1 KB)  PDF (433 KB)  ( 30 ) 98 Anesthetic effect of Ropivacaine combined with different concentrations of Sufentanil on labor analgesia CAO Lei ；ZHAO Peng ；HE Chen Objective To explore the anesthesia effect of Ropivacaine combined with different concentrations of Sufentanil on labor analgesia.Methods A total of 210 pregnant women who were admitted to Beijing Yanhua Hospital from March 2018 to March 2020 were selected as the research subjects.They were divided into low concentration group (n=105) and high concentration group (n=105) according to the random number table method.The pregnant women in low concentration group were anesthetized with 0.1% Ropivacaine+0.2 μg/ml Sufentanil,and pregnant women in high concentration group were anesthetized with 0.1% Ropivacaine+0.4 μg/ml Sufentanil.The short-from McGill pain questionnaire (SF-MPQ) score after 30 and 50 min of anesthesia,when the uterine opening to the ten fingers,and at delivery,onset time of pain control,maintenance time of pain control,postpartum blood loss and incidence of adverse reactions were compared between the two groups.Results The SF-MPQ scores of the high concentration group were lower than those of the low concentration group after 30 and 50 min of anesthesia,when the uterine orificium was opened to ten fingers,and at delivery,the differences were statistically significant (P＜0.05).The onset time of pain control in the high concentration group was shorter than that in the low concentration group,the maintenance time of pain control was longer than that in the low concentration group,and the postpartum blood loss was less than that in the low concentration group,the differences were statistically significant (P＜0.05).There was no significant difference in the total incidence of adverse reactions between the two groups (P＞0.05).Conclusion Pregnant women receiving 0.1% Ropivacaine+0.4 μg/ml Sufentanil during childbirth are more effective,has a faster onset analgesia,which can more effectively reduce the pain of pregnant women,prolong the analgesia time,reduce postpartum hemorrhage,and does not increase the incidence of adverse reactions of anesthesia compared with those in 0.1% Ropivacaine + 0.2 μg/ml Sufentanil. 2022 Vol. 29 (7): 98-100 [Abstract] ( 39 ) HTML (1 KB)  PDF (412 KB)  ( 17 ) 101 Value of spatio-temporal image correlation combined with multiplanar mode and tomography ultrasound imaging mode in the diagnosis of benign and malignant lesions in axillary lymph nodes GAN Fengping；BAI Xue ；XIAO Xuehua ；YANG Xiaoguang ；TANG Xiao ；YANG Haiyun Objective To explore the value of spatio-temporal image correlation (STIC) combined with multiplanar (MP)mode and tomography ultrasound imaging (TUI) mode in the diagnosis of benign and malignant lesions in axillary lymph nodes.Methods A total of 96 patients with axillary lymph nodes lesions admitted to Affiliated Hospital of Jiujiang University were enrolled as the research objects between January 2020 and September 2021.Among them,59 lesions on the left side and 53 lesions on the right side were detected,a total of 112.All patients underwent pathological biopsy,STIC technique combined with MP and TUI mode.Pathological results were taken as the gold standard,the sensitivity,specificity,accuracy and consistency with the gold standard of STIC combined with MP and TUI patterns in diagnosing benign and malignant axillary lymphadenopathy were analyzed.ROC curve was used to analyze the differential diagnosis value of STIC combined with MP and TUI mode for benign and malignant axillary lymph node lesions.Results The pathological results showed that there were 69 sites with benign axillary lymphadenopathy and 43 sites with malignant axillary lymphadenopathy.The sensitivity,specificity,accuracy, Kappa value and Youden index of STIC combined with MP mode and TUI mode in the diagnosis of benign and malignant axillary lymph node lesions were 93.02%,89.86%,91.07%,0.815 and 0.829,respectively.ROC curve analysis showed that the AUC of STIC-MP combined with STIC-TUI in the diagnosis of benign and malignant axillary lymph node lesions was 0.914.Conclusion The consistency between STIC combined with MP mode and TUI mode and the golden standard is high in the diagnosis of benign and malignant axillary lymph nodes,which can be applied to identify the pathological properties of axillary lymph nodes. 2022 Vol. 29 (7): 101-103 [Abstract] ( 33 ) HTML (1 KB)  PDF (518 KB)  ( 18 ) 104 Diagnostic value of spectrum CT angiography in periampullary carcinoma and preoperative staging CHEN Liang ；FU Zhiying； Hu Hanming； WU Qiheng ；LIU Xia； WANG Xiaofang Objective To explore the value of spectral CT angiography in the diagnosis of periampullary carcinoma and its preoperative staging.Methods A total of 60 patients with suspected periampullary carcinoma in Pingxiang People′s Hospital,Jiangxi Province were enrolled between July 2016 and December 2020.All underwent routine enhanced CT scan and spectral CT angiography before surgery.Using the pathological results of surgery or biopsy as the gold standard,the value of energy spectrum CT angiography in diagnosis and preoperative staging was analyzed.Results A total of 44 cases confirmed with periampullary carcinoma by surgery or biopsy,and 16 cases with periampullary inflammatory lumps.The sensitivity,specificity,accuracy,positive predictive value and negative predictive value of spectral CT angiography in the diagnosis of benign and malignant lesions were 93.18%,93.76%,93.33%,97.62% and 83.33%,greater than those of routine enhanced CT scan of 77.27%,62.50%,73.33%,85.00%,50.00%.Among the 41 patients confirmed with periampullary carcinoma by both spectral CT angiography and pathological diagnosis,there were 4 cases with T staging at stage T1,21 cases at T2,13 cases at T3 stage and 3 cases at T4.The results of spectral CT angiography showed that there were 5 cases with T staging at stage T1,20 cases at T2,12 cases at T3 stage and 4 cases at T4.The consistency Kappa values between spectral CT angiography and pathological diagnosis for stages T1,T2,T3 and T4 were 0.626,0.659,0.597 and 0.532,respectively.Conclusion The spectral CT angiography is of high diagnostic value for periampullary carcinoma,which can guide preoperative T staging of periampullary carcinoma. 2022 Vol. 29 (7): 104-106转110 [Abstract] ( 27 ) HTML (1 KB)  PDF (521 KB)  ( 31 ) 107 Comparative study on the image quality of portal vein angiography between energy spectrum CT single energy imaging and conventional enhanced CT DENG Xingxing Objective To investigate the effect of energy spectrum computed tomography (CT) single energy imaging and conventional enhanced CT on the image quality of portal vein angiography.Methods From June 2020 to June 2021,100 patients with hepatitis and liver cirrhosis with abnormal portal system or gastroesophageal varices confirmed by endoscopy in the imaging department of Ganzhou people′s Hospital from June 2020 to December 2021 were selected as the research objects.They were divided into study group (n=50) and control group (n=50) by random number table method.The study group performed energy spectrum CT single energy imaging (GSI) enhanced scan,and the control group took conventional enhanced CT scan.The general conditions of the two groups,effective radiation dose,volumetric CT dose index (CTDIvol),contrast medium iodine intake,objective and subjective scores of image quality were counted.Results The effective radiation dose and CTDIvol of the study group were not significantly different from the control group (P＞0.05).The contrast agent iodine intake amount was lower than the control group,the difference was statistically significant (P＜0.05);the CT value of the main portal vein,and the right portal vein in the study group were greater than that of the control group,the CT value of the left portal vein was lower than that of the control group,and the noise of the portal vein,the left portal vein and the right portal vein were lower than the control group,the contrast-to noise ratio (CNR) of the intrahepatic portal vein was higher than that of the control group,and the differences were statistically significant (P＜0.05).Compared with the control group,the CNR of the extrahepatic portal vein and subjective score were not statistically different (P＞0.05).Conclusion Under the condition of equivalent radiation dose,the image quality of energy spectrum CT single-energy imaging in portal vein vascular imaging is better than that of conventional enhanced CT,and the contrast agent iodine intake is less. 2022 Vol. 29 (7): 107-110 [Abstract] ( 33 ) HTML (1 KB)  PDF (512 KB)  ( 32 ) 111 Effect and imaging findings of multi-slice spiral CT in the diagnosis of rib fracture YANG Lin；CHEN Xinyi；ZHAO Wei Objective To investigate the effect and imaging manifestations of multi-slice spiral CT in the diagnosis of rib fractures.Methods A total of 100 patients with suspected rib fractures admitted to the Provincial Hospital of Shandong First Medical University from January 2019 to January 2021 were selected as the research objects,and the patients were examined by multi-slice spiral CT and digital photographic DR diagnosis.The clinical surgical diagnosis results was used as the gold standard to compare the specificity,sensitivity,accuracy,diagnosis of complications,and imaging performance of different diagnostic measures.Results Among 100 patients with suspected rib fractures,87 cases of rib fractures were confirmed by clinical final diagnosis.The sensitivity,specificity,and accuracy of CT diagnosis were higher than those of digital photographic DR examination,and the differences were statistically significant (P＜0.05).There was no statistically significant difference in positive predictive value between the two methods (P＞0.05).The detection rate of spiral CT in the diagnosis of pneumothorax and pulmonary contusion were higher than those of digital photographic DR examination,and the differences were statistically significant (P＜0.05).Conclusion For patients with rib fractures,both multi-slice spiral CT and digital photographic DR examination have clinical diagnostic value,but multi-slice spiral CT technology has higher diagnostic accuracy and can provide more direct feedback on the fracture status of patients.The program is worth recommending. 2022 Vol. 29 (7): 111-114 [Abstract] ( 41 ) HTML (1 KB)  PDF (567 KB)  ( 17 ) 115 Analysis of adverse reactions in patients treated with injections of the anti-tumor drug Paclitaxel SHENG Nan Objective To observe the incidence of adverse reactions in patients treated with injections of anti-tumor drug Paclitaxel in Central Hospital of Wafangdian City,Liaoning Province from December 2017 to December 2019.Methods The clinical data of 130 patients treated with injections of Paclitaxel from December 2017 to December 2019 in the Central Hospital of Wafangdian City,Liaoning Province were retrospectively analyzed,and the incidence of adverse reactions in the patients were observed and analyzed.Results All the 130 patients had adverse reactions of varying degrees,among which the incidence rates of bone marrow suppression (23.08%),alopecia (19.23%) and intestinal reactions (16.92%) were high,and the incidence rates of other adverse reactions such as allergic reactions,joint or muscle pain,blood system diseases,nephrotoxicity,cardiotoxicity and fever were low.In patients of all ages,the incidence of adverse reactions was higher in patients ＞60 years old,accounting for 50.00%.More patients (43.85%) experienced adverse reactions after 8 to 15 days of Paclitaxel treatment.Conclusion Patients treated with the Paclitaxel Injection,the anti-tumor drug,will have adverse reactions of varying degrees,and the high-risk period of adverse reactions is 8 to 15 days after the beginning of the use of Paclitaxel.In the monitoring of drug safety in patients of all ages,special attention should be paid to the specific situation of elderly patients after medication.Prophylactic medication is recommended to reduce the incidence of adverse drug reactions. 2022 Vol. 29 (7): 115-117转121 [Abstract] ( 40 ) HTML (1 KB)  PDF (427 KB)  ( 37 ) 118 Clinical study of Zoledronic Acid Injection in the treatment of senile osteoporosis LI Kunlang Objective To investigate the clinical efficacy and safety of Zoledronic Acid Injection,Ossotide Injection and Vitamin D2 Phosphate Calcium Glucose Tablets combined in the treatment of senile osteoporosis.Methods A total of 44 elderly patients with osteoporosis admitted to Gaozhou People′s Hospital from July 2017 to June 2019 were selected as the research objects,and they were divided into control group (22 cases) and treatment group (22 cases) by random number table method.Control group received routine treatment (Vitamin D2 Phosphate Calcium Glucose Tablets+Ossotide Injection).Patients in the treatment group received combined treatment(Vitamin D2 Phosphate Calcium Glucose Tablets + Ossotide Injection + Zoledronic Acid Injection).Both groups were treated for 6 months.The total effective rate,bone mineral density of lumbar spine and femoral neck before and after treatment,and the total incidence of adverse reactions were compared between the two groups.Results After treatment,the total effective rate of the treatment group (95.45%) was higher than that of the control group (59.09%),and the difference was statistically significant (P＜0.05).After treatment,the bone mineral density of lumbar L1-4 and femoral neck in the two groups were higher than those before treatment,and the bone mineral density of lumbar L1-4 and femoral neck in treatment group were higher than those in control group,the differences were statistically significant (P＜0.05).During treatment,the total incidence of adverse reactions in the treatment group (13.64%) was lower than that in the control group (100.00%),the difference was statistically significant (P ＜0.05).Conclusion Zoledronic Acid Injection,Ossotide Injection and Vitamin D2 Phosphate Calcium Glucose Tablets combined can effectively improve the bone density of elderly patients with osteoporosis,with significant efficacy and high safety. 2022 Vol. 29 (7): 118-121 [Abstract] ( 35 ) HTML (1 KB)  PDF (443 KB)  ( 22 ) 122 Experience of Professor YOU Jianliang in treating malignant tumor with insect drugs YU Xueqin；YOU Jianliang Malignant tumors grow and metastasize rapidly,as fast as the wind,which is in line with the characteristics of "wind being mobile and changeable".So we need to reverse their development trend urgently.Cancer toxin is the key factor of malignant tumor,Which is produced on the basis of positive deficiency.The later stage of malignant tumors becomes heavier with long time.The disease pathogen is difficult to cure,which is based on the Theory of“Chronic Diseases Transforming to Collaterals".Insect drugs are sentimental products of flesh and blood.They have a acrid and salty taste.Acrid taste can spread.Salty taste can soften hardness.They have the nature of channeling.The effects of promoting blood circulation,dredging collaterals,soften hardness and dissolve lump are unmatched by plants,trees and minerals.They have a rapid effect and meet the condition,which can be used widely.Professor YOU Jianliang is good at utilize insect drugs of different properties and effects to treat various malignant tumors,Such as stiff silkworm,beehive,scorpion,centipede,earthworm,cicada slough,gecko,Jiuxiang insect, etc.It has significant clinical effect.Insect drugs have the disadvantages of moving blood and consuming qi.Clinically,they should be used carefully according to the deficiency and excess of good and evil.The property of most insect drugs is fierce.So they are often combined with traditional Chinese medicines such as adjusting and compensating medium coke,harmonizing the stomach and stopping vomiting,dispelling wind and stopping itching to reduce their side effects.On the basis of syndrome differentiation and treatment,he combined modern pharmacological research,traditional Chinese medicine and Western medicine to reduce toxicity and increase efficiency.Professor YOU Jianliang′s experience in using insect drugs to treat malignant tumors is worthy of our study,which is conducive to broaden clinical ideas and improve clinical efficacy. 2022 Vol. 29 (7): 122-125 [Abstract] ( 39 ) HTML (1 KB)  PDF (474 KB)  ( 46 ) 126 Effect of Wuling Powder and Danggui Buxue Decoction in treating swelling of limbs with fractures WANG Daguang Objective To investigate the effect of Wuling Powder and Danggui Buxue Decoction in the treatment of swelling of limbs.Methods A total of 150 patients with fractured limbs and swelling who were treated at the Caidian District Hospital of Traditional Chinese Medicine in Wuhan City from December 2019 to January 2021 were selected as the research objects,according to the random number table method,they were divided into control group (75 cases) and observation group (75 cases).The control group was given routine treatment.The observation group was treated with Wuling Powder and Danggui Buxue Decoction.The clinical symptom scores of the two groups were compared before and after treatment (visual analogue scale[VAS],limb swelling degree,adjacent joint range of motion score),bone metabolism index level (osteocalcin[BGP],serum alkaline phosphatase[ALP],type I procollagen carboxy-terminal peptide[PICP]and bone morphogenetic protein-2[BMP-2]),bone callus Growth condition[callus density,callus volume,callus edge,growth condition of stump edge]and clinical efficacy.Results Before treatment,there was no significant difference in the VAS score,the degree of swelling of limbs and the range of motion of adjacent joints between the two groups (P＞0.05).The scores were lower than those before treatment in this group,and the differences were statistically significant (P＜0.05).After treatment,the VAS score,the degree of swelling of the limbs and the range of motion of adjacent joints in the observation group were lower than those in the control group,and the differences were statistically significant (P＜0.05).Before treatment,there was no significant difference in the levels of BGP,ALP,PICP and BMP-2 between the two groups (P＞0.05).After treatment,the levels of BGP,ALP,PICP and BMP-2 in the two groups were higher than before treatment,the differences were statistically significant in this group (P＜0.05).After treatment,the levels of BGP,ALP,PICP and BMP-2 in the observation group were higher than those in the control group,and the differences were statistically significant (P＜0.05).Before treatment,there was no significant difference in the callus density,callus volume,callus edge and fracture edge growth score between the two groups (P＞0.05).The volume,callus edge,and fracture edge growth scores of the patients in the observation group were higher than those before treatment,and the differences were statistically significant (P＜0.05).The end-edge growth scores were higher than those in the control group,and the differences were statistically significant (P＜0.05).The total effective rate of clinical treatment in the observation group was 93.33% (70/75) higher than that in the control group,which was 81.33% (61/75),and the difference was statistically significant (P＜0.05).Conclusion The treatment of Wulingsan combined with Danggui Buxue Decoction for patients with swelling of fractured limbs can effectively reduce the symptoms of swelling and pain,improve the level of bone metabolism and promote the growth of callus,which is beneficial to fracture healing. 2022 Vol. 29 (7): 126-129 [Abstract] ( 34 ) HTML (1 KB)  PDF (476 KB)  ( 24 ) 130 Influencing factors of preoperative disease uncertainty in patients with non-melanoma skin cancer GAN Leimeng ；TAN Xiuzhu ；LUO Qin ；TANG Xi ；YAO Keru； YIN Xinhong▲ Objective To investigate the current status and influencing factors of preoperative illness uncertainty of patients with non-melanoma skin cancer (NMSC).Methods A total of 150 patients who underwent excision of skin malignant tumor surgery in Shanghai Dermatology Hospital from October 2020 to March 2021 were randomly selected by convenience sampling method to conduct a questionnaire survey,and the influencing factors of preoperative disease uncertainty in NMSC patients were analyzed.Results The total score of preoperative disease uncertainty scale (MUIS-A)and anxiety score of NMSC patients were (89.89±7.41) and (56.66±9.12) respectively.Preoperative MUIS-A score was positively correlated with anxiety (r=0.375, P＜0.01).Univariate analysis showed that there were statistically significant differences in preoperative MUIS-A scores among patients with different gender,age,education level,tumor site,previous skin cancer operation history and anxiety (P＜0.05).Multivariate analysis showed that male (β=-3.253, OR=0.039,95%CI=-5.045 to -1.460) and previous history of skin cancer surgery (β=-4.896, OR=0.007,95%CI=-8.023 to -1.769) were protective factors for preoperative uncertainty of disease (P＜0.05).Low educational level (β=6.532, OR=6.842,95%CI=3.459-9.605 ) and anxiety (β=0.113, OR=1.120,95%CI=0.010-0.216) were independent risk factors for preoperative uncertainty of disease (P＜0.05).Conclusion Preoperative disease uncertainty of NMSC patients was generally at a moderate level.Therefore,in clinical nursing work,we should implement targeted preoperative health education to relieve patients′ anxiety and reduce preoperative disease uncertainty. 2022 Vol. 29 (7): 130-133 [Abstract] ( 38 ) HTML (1 KB)  PDF (490 KB)  ( 22 ) 134 Epidemiological characteristics of paediatric emergency trauma XU Lingjun；CHI Keqiang；LI Qing； YUAN Lingfeng；XU Nanping Objective To investigate the pediatric emergency trauma in Children′s Hospital of Jiangxi Province and understand its epidemiological characteristics.Methods The clinical data of 739 trauma children who admitted to the Department of Emergency at Children′s Hospital of Jiangxi Province from August 2020 to July 2021 were analyzed retrospectively.The analysis was carried on children′s gender,age,month,trauma,location of trauma,cause,prehospital disposal,and outcome of trauma.The intuitive statistical figure was made from these relevant data and the data were analysized between the groups according to the pediatric trauma score (PTS) which were divided into the group of PTS≥8 and the group of PTS＜8.Results There are 739 children with trauma in total,including 441 males and 298 females.The ratio of the males and females is 1.5∶1.Trauma children aged 2-4 years were the most.The most common months of trauma were February and July to August.Trauma occurs mainly in family and road,falls and traffic accidents were the main reason of injury and the injuries of brain were most.Among the included children,there were 671 cases in the group of PTS≥8 points and 68 cases in the group of PTS＜8 points.There were no significant differences in sex,age,location or month between the two groups (P＞0.05).The severe trauma were mainly the fall injuries from heights(47.1%) and the injuries of traffic accident (36.8%),the majority were brain injuries (38.2%) and multiple injuries(54.4%).In the cause of trauma,the percentage of the fall injuries from heights in the group of PTS＜8 points were obviously more than that in the group of PTS ≥8 points,the difference between the two groups was statistically significant (P＜0.001).In the location of trauma,the percentage of the multiple injuries in the group of PTS＜8 points were obviously more than that in the group of PTS≥8 points,the difference between the two groups was statistically significant (P＜0.001).78.1% of trauma children were transported for more than 1 hour,and 80.0% of children with severe trauma lacked adequate prehospital treatment and there were many sequelae among them.Conclusion Understanding the characteristics of pediatric emergency trauma is helpful to develop scientific and reasonable prevention and control measures. 2022 Vol. 29 (7): 134-138 [Abstract] ( 37 ) HTML (1 KB)  PDF (501 KB)  ( 22 ) 139 Etiological analysis of 620 adult patients with community acquired pneumonia in southeast of Beijing LIU Ce；YE Fang； JIANG Qiaoqiao； MA Jianxin Objective To investigate the etiological distribution of adult community-acquired pneumonia (CAP) in southeast of Beijing,and to provide evidence for the empirical treatment of CAP.Methods The etiological distribution of 620 CAP patients in Beijing Chuiyangliu Hospital from October 1,2016 to April 30,2020 was analyzed retrospectively.Results The positive rate of atypical pathogens was 40.8%, Mycoplasma pneumoniae was 39.4%;bacteria was 56.8%, Streptococcus pneumoniae was 35.8%, Haemophilus influenzae was 19.0%;the positive rate of virus was 19.7%,influenza A was 5.6%,parainfluenza virus was 5.6%.The positive rate of mixed infection was 43.5%, Streptococcus pneumoniae combined with mycoplasma pneumoniae infection is the most common.Conclusion Mycoplasma pneumoniae is the first pathogen of adult CAP in southeast of Beijing,followed by Streptococcus pneumoniae and Haemophilus influenzae.Influenza A virus and parainfluenza virus are the most common viral pathogens.The mixed infection rate of CAP was high in this area.This study initially revealed the characteristics of aetiological distribution of CAP in adults in the region,and provided etiological evidence for empiric therapy. 2022 Vol. 29 (7): 139-142转150 [Abstract] ( 38 ) HTML (1 KB)  PDF (813 KB)  ( 70 ) 143 Gene analysis of a family with alveolar microlithiasis HU Qiufang；ZHANG Juan；SHENG Tianxin； YANG Xiaodong；CHEN Sihan Pulmonary alveolar microlithiasis (PAM) is a rarely occurred pulmonary disorder characterized by precipitation of granules of calcium phosphate in bilateral pulmonary alveoli.Recent studies showed PAM has a familial hereditary preference,mostly is autosomal recessive,of them,mutation of solute carrier family 34 member 2 (SLC34A2) is dominant,but the mutation spot is different with countries,for further discussing about the gene mutation in Chinese PAM patients,the clinical data of 1 PAM patient and the peripheral blood samples of his pedigree were collected and tested with PCR and DNA sequencing on SLC34A2 mutation.The results showed a mutation c.910A＞T (p.K304X) on exon 8 of SLC34A2 in the patient and his father,and mutations simultaneously on 2 SNP sites,i.e.,on the 3′-UTR region of exon 13 and c.1363T＞C (p.Y455H) on intron 12,in the patient and his mother.Mutations simultaneously on 2 SNP sites are a newly-detected pattern which is not reported in the literature,the mutation spot in Chinese PAM patients prefers on exon 8,further investigation is needed to observe the possibility of etiology caused by pathogenic compound heterozygous mutations. 2022 Vol. 29 (7): 143-146 [Abstract] ( 34 ) HTML (1 KB)  PDF (996 KB)  ( 18 ) 147 A case of atypical polypoid adenomyoma of the endometrium after menopause ZOU Purun；LIN Tong； ZHOU Weihua Endometrial atypical polypoid adenomyoma（APA) is a special type of endometrial polypoid lesion,which is relatively rare in clinical work.It mostly occurs in premenopausal women,and rarely occurs in postmenopausal women.Abnormal vaginal bleeding,pelvic pain,infertility,intrauterine mass,and vaginal discharge,etc.,are diagnosed by pathological examination.APA is a benign lesion with a low incidence rate,but it has the potential of recurrence and low-grade malignant transformation,which should be paid attention to.This study shared a case of a postmenopausal woman with irregular vaginal bleeding who was diagnosed with APA by hysteroscopy and underwent total hysterectomy plus double adnexectomy.Postmenopausal APA patients are relatively rare in clinical work,and there is still a lack of experience and unified treatment principles for the diagnosis and treatment of such patients.Clinicians share and provide reference. 2022 Vol. 29 (7): 147-150 [Abstract] ( 31 ) HTML (1 KB)  PDF (1027 KB)  ( 46 ) 151 Convex subarachnoid hemorrhage presented by transient cerebral ischemia:a case report and literature study LI Guilan；FENG Zhenxing；YANG Shuiquan Convexal subarachnoid hemorrhage (cSAH) is characterized by simple subarachnoid hemorrhage.The etiology and clinical manifestations of cSAH are varied,and transient cerebral ischemia is rare.In addition,the most cases of cSAH reported stenosis or occlusion of responsible vessels in the anterior circulation,while the presence of responsible vessels in the posterior circulation of cSAH was rare.The case mentioned in this study was cSAH presented by transient cerebral ischemia,and the patient was basilar artery stenosis or occlusion with left parietal cSAH.The patient was clinically stable after treatment with stable plaque.This case suggests that narrowing or occlusion of the basilar artery may cause cSAH formation.Although the etiology of this disease has not been determined,the patient did not have an adverse prognosis. 2022 Vol. 29 (7): 151-153转156 [Abstract] ( 36 ) HTML (1 KB)  PDF (741 KB)  ( 26 ) 154 A case report of early gastric cancer with low grade internal neoplasia and literature review FU Daoshi；CAO Antao Low grade intraepithelial neoplasia of gastric mucosa (LGIN) is precancerous,which has the potential to become cancerous.However,the long-term clinical outcome of LGIN has two conditions,some of which can be reversed,and some have the potential for malignant transformation,thus causing difficulties in clinical management.Whether to follow up closely or carry out certain intervention measures needs to be further discussed.The case was diagnosed as chronic atrophic gastritis with low-grade internal neoplasia (mild heterosexual hyperplasia) by gastroscopy and pathological repetitious examinations in this paper.In 2021,the second mucosal biopsy performed by gastroscopy was still"moderate chronic atrophic gastritis accompanied by mild heterosexual hyperplasia".However,the microvessels of the lesion were considered a disorder through the observation of blue light imaging magnifying endoscopy Microstructure.The lesion showed a concave change with redness on the surface,and the scope of the lesion was significantly enlarged compared with the period from 2018 to 2020,and was ＞2 cm.Early gastric cancer was highly considered and finally diagnosed by endoscopic mucosal dissection (ESD).This case report and literature review provide experience and reference for clinicians in the diagnosis and treatment of LGIN. 2022 Vol. 29 (7): 154-156 [Abstract] ( 34 ) HTML (1 KB)  PDF (988 KB)  ( 39 ) 157 Effect of pain specialist nurse in pain management and nursing intervention in painless gastrointestinal endoscopy SU Liping；YE Fan； HAN Ke Objective To explore the effect of pain specialist nurse in pain management and nursing intervention in painless gastrointestinal endoscopy.Methods A total of 100 patients with painless gastrointestinal endoscopy admitted to the Department of Outpatient,the Third People′s Hospital of Pingxiang City and the Fourth Affiliated Hospital of Nanchang University from May 2019 to May 2021 were selected as the research objects,and they were divided into the control group (50 cases) and the intervention group (50 cases) according to the random lottery method.The control group used traditional nursing care,and the intervention group used pain specialist nurses to perform pain management and nursing intervention.The examination success,clinical indexes,adverse events and nursing satisfaction of the two groups were compared.Results The examination success rate of the two groups were 100.00%.The systolic blood pressure,diastolic blood pressure and heart rate of the intervention group were lower than those of the control group,and the blood oxygen saturation of the intervention group was higher than that of the control group,the differences were statistically significant (P＜0.05).The incidence of adverse events in the intervention group was lower than that in the control group,the difference was statistically significant (P＜0.05).The nursing satisfaction of the intervention group was higher than that of the control group,the difference was statistically significant (P＜0.05).Conclusion The effect of pain management and nursing intervention implemented by pain specialist nurses in painless gastroenteroscopy is remarkable.While ensuring the success of examination,it can improve the clinical indicators of patients,reduce adverse events and obtain higher nursing satisfaction.It is worthy of popularization and application. 2022 Vol. 29 (7): 157-159 [Abstract] ( 38 ) HTML (1 KB)  PDF (656 KB)  ( 22 ) 160 Nursing study of endo-bronchial ultrasound-guided transbronchial needle aspiration after general anesthesia LIU Yuan ；LI Qianqian； HUANG Tingting ；HUANG Kai； XU Bing； XIAO Huaping Objective To investigate the application effect of precise nursing in patients under endo-bronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) after general anesthesia.Methods A retrospective analysis was conducted on 40 patients with pulmonary nodules and lung placeholder admitted to Jiangxi Cancer Hospital from January 2020 to January 2021.All patients received EBUS-TBNA general anesthesia,and were divided into observation group and control group by different nursing methods,with 20 patients in each group.Patients in the control group received routine nursing after EBUS-TBNA general anesthesia,and patients in the observation group received precise nursing based on routine nursing after EBUS-TBNA general anesthesia.The amount of blood loss at 48 h after operation,incidence of postoperative chest distress,satisfaction rate of sampling and total incidence of complications were compared between the two groups.Results The amount of blood loss at 48 h after operation in observation group was less than that in the control group,the difference was statistically significant (P＜0.05).The incidence of postoperative chest distress and total incidence of complications in the observation group were lower than those in the control group,with statistical significances (P＜0.05).The satisfaction rate of sampling of the observation group was higher than that of the control group,and the difference was statistically significant (P＜0.05).Conclusion The application effect of precise nursing in EBUS-TBNA patients after general anesthesia is significant,which can reduce the incidence of complications and ensure the safety of patients. 2022 Vol. 29 (7): 160-162转167 [Abstract] ( 38 ) HTML (1 KB)  PDF (715 KB)  ( 21 ) 163 Application effect of in-hospital simulated home rehabilitation combined with out-of-hospital planning home rehabilitation environment in elderly patients with coronary heart disease XIONG Yali ；LOU Juan； WANG Lijun ；ZHANG Xiyan ；LIU Zhihui； HUANG Ming Objective To explore the application effect of in-hospital simulated home rehabilitation combined with planning the out-of-hospital environment of home rehabilitation in elderly patients with coronary heart disease.Methods A total of 100 elderly patients with coronary heart disease treated in Jingdezhen First People′s Hospital from September 2019 to December 2020 were selected as the research object.According to the order of admission,50 patients hospitalized from September 2019 to April 2020 were set as the control group,and 50 patients hospitalized from May to December 2020 were divided into the experimental group.The control group used telephone to guide the patients′ home rehabilitation,and the test group gave in-hospital simulated home rehabilitation combined with out-ofhospital planning home rehabilitation on the basis of the intervention of the control group.The 6-minute walking distance(6MWD),health questionnaire depression scale(PHQ 9),generalized anxiety disorder scale(GAD7) and Seattle angina questionnaire score(SAQ)were compared between the two groups.Results After 12 weeks of intervention,the 6MWD in the test group was higher than that of the control group,the difference was statistically significant (P＜0.05).The scores of PHQ9 and GAD7 in the test group were lower than those of the control group,the differences were statistically significant (P＜0.05).The scores of all dimensions of SAQ in the test group were higher than those of the control group,the differences were statistically significant (P＜0.05).Conclusion In-hospital simulated home rehabilitation combined with out-of-hospital planning home rehabilitation environment can improve the exercise endurance and mental state of elderly patients with coronary heart disease,and improve the quality of life. 2022 Vol. 29 (7): 163-167 [Abstract] ( 42 ) HTML (1 KB)  PDF (712 KB)  ( 24 ) 168 Influence of cognitive psychological intervention on psychological resilience and self-care ability of maintenance hemodialysis patients ZHOU Qizhen； ZHOU Wenying； LUO Ting； LI Fang； YI Qinxia； SHI Chunzhen Objective To explore the influence of cognitive psychological intervention on psychological resilience and self-care ability of maintenance hemodialysis patients.Methods A total of 90 patients with maintenance hemodialysis in Jiujiang Hospital of Traditional Chinese Medicine from April 2019 to December 2020 were selected and divided into the observation group and the reference group group according to the random number table method,45 cases in each group.The patients in the reference group group received routine nursing in maintenance hemodialysis,the observation group was given cognitive psychological intervention on the basis of routine nursing.The Chinese version of Connor Davidson resilience scale (CD-RISC) was used to evaluate the psychological resilience of the two groups.Exercise of Self-Care Agency Scale (ESCA) was used to evaluate the self-care ability of the two groups.The Medical Outcomes Study 36-Item Short-Form Health Survey (SF-36) was used to evaluate the quality of life of the two groups.Results Before the intervention,there were no significant difference in the CD-RISC three dimensional scores and the total scores between the two groups (P＞0.05).After the intervention,the CD-RISC three dimensional scores and the total scores of the two groups were higher than those before the intervention (P＜0.05),and the CD-RISC three dimensional scores and the total scores of the observation group were higher than those of the reference group,and the differences were statistically significant (P＜0.05).Before the intervention,there were no significant difference in the scores of each dimension and the total score of ESCA between the two groups (P＞0.05).After the intervention,the scores of each dimension and the total score of ESCA in the two groups were higher than those before the intervention (P＜0.05),and the scores of each dimension and the total score of ESCA in the observation group were higher than those in the reference group,and the differences were statistically significant(P＜0.05).Before the intervention,there was no significant difference in the quality of life scores between the two groups(P＞0.05).After the intervention,the quality of life scores of the two groups were higher than before the intervention (P＜0.05),and the quality of life score of the observation group was higher than that of the reference group,and the differences were statistically significant (P＜0.05).Conclusion Cognitive psychological intervention can improve the psychological resilience and self-care ability of maintenance hemodialysis patients,and help to improve the quality of life of patients. 2022 Vol. 29 (7): 168-171 [Abstract] ( 41 ) HTML (1 KB)  PDF (664 KB)  ( 28 ) 172 Application effect of programmed nursing under the guidance of optimized sedation and analgesia strategy in patients with mechanical ventilation in intensive care unit LIN Zhanqiu； LUO Xiaoyan； YU Meiying Objective To explore the application effect of programmed nursing under the guidance of optimized sedation and analgesia strategy in patients with mechanical ventilation in intensive care unit (ICU).Methods From January 2019 to January 2021,100 patients with mechanical ventilation treated in ICU of Department of Critical Medicine in Yunfu Hospital of Traditional Chinese Medicine,the Second Affiliated Hospital of Guangdong Pharmaceutical University were selected as the research object.They were divided into the study group(50 cases)and the control group(50 cases) according to random number table method.The control group received routine ICU care,the study group used programmed nursing under the guidance of optimized sedation and analgesia strategy.The mechanical ventilation time and ICU nursing time of the two groups were compared,the sedation and analgesia status before the intervention and 3 days after the intervention were observed,and the muscle strength and adverse events (delirium,fall,fall out of bed,unplanned extubation and decrease of blood oxygen saturation) at the end of ICU treatment were recorded.Results The mechanical ventilation time and ICU nursing time of the study group were shorter than those of the control group,and the differences were statistically significant (P＜0.05).The sedation and analgesia scores of the two groups after intervention were lower than those of the control group (P＜0.05),and the sedation and analgesia score of the study group after intervention were lower than those of the control group,the differences were statistically significant (P＜0.05).At the end of ICU treatment,the muscle strength score of Medical Research Committee (MRC) and the incidence of ICU-acquired weakness (ICU-AW) in the study group were significantly lower than those in the control group,the differences were statistically significant (P＜0.05).The total incidence of adverse events in the study group (4.00%) was lower than that in the control group (20.00%),the difference was statistically significant (P＜0.05).Conclusion Programmed nursing intervention under the guidance of optimizing sedation and analgesia strategy can shorten the time of mechanical ventilation,accelerate the speed of coming out of ICU,have better sedation and analgesia,improve muscle strength and reduce the total incidence of adverse events during mechanical ventilation. 2022 Vol. 29 (7): 172-175转179 [Abstract] ( 40 ) HTML (1 KB)  PDF (728 KB)  ( 78 ) 176 Influence of two-way quality feedback mode on the mental state of cesarean puerpera in preeclampsia and their postpartum recovery LU Jinfang； ZHU Huijuan；HE Qitao； LAI Qiaohong；YAN Dongqin Objective To explore the effect of two-way quality feedback mode in preeclampsia cesarean section women.Methods A total of 98 cases of preeclampsia cesarean section puerpera admitted to the Department of Obstetrics and Gynecology,Xiaolan People′s Hospital from June 2019 to March 2021 were selected as the research objects,they were divided into two groups according to random number table method,with 49 cases in each group.The control group was given routine nursing care,and the observation group was treated with a two-way quality feedback model,and the observation was continued until the puerpera were discharged from the hospital.The psychological status,postoperative recovery,postoperative pain and complications of the two groups were compared.Results There was no statistically significant difference in the psychological status between the two groups before the intervention (P＞0.05).After the intervention,the self-rating anxiety scale (SAS) and self-rating depression scale (SDS) of the two groups were lower than those before the intervention,and the scores of the observation group were higher than those of the control group,the differences were statistically significant (P＜0.05).The post-recovery time of the observation group was shorter than that of the control group,the postoperative pain degree was lighter than that of the control group,and the incidence of complications was lower than that of the control group,the differences were statistically significant (P＜0.05).Conclusion The two-way quality feedback model can reduce the negative emotions and postoperative pain of preeclampsia puerpera during cesarean section,effectively promote the postoperative recovery of the puerpera,reduce the risk of complications,and shorten the postoperative hospital stay. 2022 Vol. 29 (7): 176-179 [Abstract] ( 37 ) HTML (1 KB)  PDF (664 KB)  ( 27 ) 180 Analysis of the prevention effect of pressure ulcer risk early warning system on hospital-acquired pressure ulcers during postoperative rehabilitation of elderly patients GONG Xialing ；LIU Ying ；XU Peipei Objective To analyze the efficacy of pressure ulcer risk warning system in the prevention of hospital-acquired pressure ulcer (HAPU) in elderly patients during postoperative rehabilitation.Methods A total of 200 elderly patients who underwent surgical treatment in Linchuan District People′s Hospital from January 2019 to December 2020 were selected as the research objects.They were divided into the observation group and the control group by random number table method,with 100 cases in each group.Routine nursing intervention was implemented in the control group during postoperative rehabilitation,and nursing intervention was carried out in the observation group on the basis of pressure ulcer risk warning system in the control group.The of total incidence of HAPU,pressure ulcer nursing quality and quality of life before and after nursing were compared between the two groups.Results The total incidence of HAPU in the observation group after nursing was lower than that in the control group,the difference was statistically significant (P＜0.05).The timely rate of pressure ulcer prevention decompression,the correct utilization rate of pressure ulcer prevention support surface,the correct rate of posture placement,the implementation rate of nutrition intervention and the implementation rate of health education in the observation group were higher than those in the control group,the differences were statistically significant (P＜0.05).The physiological function,mental health,physical pain,energy items scores of observation group after nursing were higher than those of the control group,the differences were statistically significant (P＜0.05).Conclusion Pressure ulcer risk warning system has significant preventive value on HAPU in elderly patients during postoperative rehabilitation,it can significantly improve the quality of care for pressure ulcer,and has important significance for improving the quality of life and prognosis of patients,so it can be considered for clinical promotion and application. 2022 Vol. 29 (7): 180-183 [Abstract] ( 51 ) HTML (1 KB)  PDF (664 KB)  ( 42 ) 184 Application effect of nursing intervention based on solution-focused approach on post-stroke fatigue patients GAO Cong； LI Guanwei； LONG Xiuhui Objective To investigate the application effect of nursing intervention based on the solution-focused approach on post-stroke fatigue patients.Methods A total of 120 stroke patients with fatigue severity scale score ≥4 who were treated in Binzhou Medical University Hospital from November 2020 to May 2021 were selected as the research objects.According to the random number table method,the patients were divided into control group and observation group,60 cases in each group.Patients in the control group were given routine neurological nursing and followup after discharge,while patients in the observation group were given solution-focused approach on the basis of the control group.The fatigue severity,neurological deficits,the degree of disability and social functioning,the self-efficacy,the ability of daily living were compared between the two groups before and after intervention.Results After intervention,the scores of fatigue severity scale,National Institutes of Health Stroke Scale,and modified Rankin scale in the observation group were lower than those in the control group,and the differences were statistically significant (P＜0.05).After intervention,the scores of stroke serf-efficacy questionnaire and Barthel index in the observation group were higher than those in the control group,and the differences were statistically significant (P＜0.05).Conclusion Nursing intervention based on the solution-focused approach can reduce the severity of fatigue in post-stroke fatigue patients,promote the recovery of neurological function,speed up the rehabilitation process,and improve the patients′self-efficacy and self-care ability,which is worthy of clinical promotion. 2022 Vol. 29 (7): 184-187 [Abstract] ( 25 ) HTML (1 KB)  PDF (668 KB)  ( 46 ) 188 Application and effect evaluation of delirium management program-based of joint evaluation in emergency elderly patients DENG Hailian； DENG Fenglian Objective To explore the effects of application of delirium management program-based of joint evaluation in emergency elderly patients.Methods To establish a management plan for delirium in emergency elderly patients which based on ABCDEF joint evaluation management program by Rawson.A total of 120 emergency elderly patients admitted to Department of Emergency,Zhongshan Hospital of Traditional Chinese Medicine from January 2019 to December 2020 were divided into the observation group (admitted from January to February 2020) and the control group(admitted from January to February 2019) by the non-contemporaneous control method,with 60 cases in each group.The control group received routine delirium management program,the observation group received delirium management program-based of joint evaluation.The incidence of delirium and duration,incidence of mechanical ventilation and duration,incidence of unplanned admission to intensive care unit (ICU) and duration,the effect of nursing satisfaction were compared between the two groups.Results The incidence of postoperative delirium in the control group was lower than that of the observation group,the difference was stastically significant (P＜0.05).The duration of delirium in the observation group was shorter than that of the control group,the difference was stastically significant (P＜0.05).The duration of mechanical ventilation in the observation group was shorter than that of the control group,the difference was stastically significant (P＜0.05).The duration of unplanned admission to intensive care unit (ICU) in the observation group was shorter than that of the control group,the difference was stastically significant (P＜0.05).There was no statistically significant difference in the incidence of unplanned admission to ICU between two groups (P＞0.05).The total score of three dimensions of satisfaction with nursing services in the observation group was higher than that of the control group,the difference was stastically significant (P＜0.05).But there were no statistically significant differences in provided help when needed,skilled nursing skills,quiet room environment,and tidy entry scores between two groups(P＞0.05).Conclusion The delirium management program-based of joint evaluation in emergency elderly patients could reduced the incidence of postoperative delirium,shorter the duration of mechanical ventilation and the duration of unplanned admission to ICU,promote the satisfaction score of nursing service. 2022 Vol. 29 (7): 188-192 [Abstract] ( 25 ) HTML (1 KB)  PDF (715 KB)  ( 19 ) 193 Application of humanistic care in the nursing of convalescent schizophrenia and its influence on patients′ self-cognition and treatment compliance LI Xuehui；OU Yingyi；ZHANG Yanping Objective To explore the application of humanistic care in the nursing of convalescent schizophrenia and its influence on self-cognition and treatment compliance.Methods A total of 86 patients with convalescent schizophrenia who were hospitalized in Mental Hospital of Guangzhou Civil Affairs Bureau from July 2019 to November 2020 were selected as subjects.They were divided into control group (n=42) and study group (n=44) by random coin toss method.Patients in the study group were provided with humanistic care,and patients in the control group were provided with routine care.The treatment compliance,changes in insight and treatment attitude questionnaire (ITAQ) score and nurses′ observation scale for inpatient evaluation (NOSIE) score and total nursing satisfaction were compared between the two groups.Results The total compliance rate of the study group was higher than that of the control group after 3 months of nursing,and the difference was statistically significant (P＜0.05).There were no significant differences in ITAQ score and NOSIE score before nursing between the two groups (P＞0.05).The ITAQ score and NOSIE score of the study group were higher than those of the control group after 3 months of nursing,the differences were statistically significant (P＜0.05).The total nursing satisfaction of the study group was higher than that of the control group after 3 months of nursing,and the difference was statistically significant (P＜0.05).Conclusion The application effect of humanistic care in the nursing of convalescent schizophrenia is ideal,which can improve patients′ self-cognitive ability and treatment compliance,and improve the nursing satisfaction of patients′ family members.It is suitable for clinical application. 2022 Vol. 29 (7): 193-196 [Abstract] ( 29 ) HTML (1 KB)  PDF (706 KB)  ( 26 )

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