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| The effect of Compound Glutamine Enteric-coated Capsules in adjuvant treatment of patients with ulcerative colitis and its influence on the rehabilitation of patients′ gastrointestinal function |
| HUANG Jingyi1 WANG Wei2 JIANG Guohua1 |
| 1.Department of Preparation Center,Foshan Traditional Chinese Medicine Hospital
2.Department of Gastroenterology,Jiangmen Central Hospital |
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Abstract Objective To study the clinical effect of Compound Glutamine Enteric-Coated Capsules on patients with ulcerative colitis (UC) and the rehabilitation effect on gastrointestinal function.Methods Ninety-two UC patients in the Department of Gastroenterology of Jiangmen Central Hospital from March 2018 to March 2021 were selected as the research objects,and they were divided into an experimental group (n=46) and a control group (n=46) by the random number table method.Patients in the experimental group were treated with Mesalamine+Compound glutamine entericcoated capsules,and patients in the control group were treated with Mesalamine.The treatment effect and the incidence of adverse reactions,the intestinal barrier function and gastrointestinal function rehabilitation indexes before and after treatment were compared between the two groups.Results The total effective rate of treatment in the experimental group (95.65%) was higher than that in the control group (82.61%),and the difference was statistically significant (P＜0.05).After treatment,the levels of diamine oxidase,D-lactic acid and bacterial endotoxin in the experimental group were lower than those in the control group,the differences were statistically significant (P＜0.05).The colonoscopy score and modified Mayo score (Mayo) in the experimental group were lower than those in the control group,and the gastrointestinal quality of life index (GIQLI) was higher than that in the control group,the differences were statistically significant (P＜0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion Compound Glutamine Enteric-Coated Capsules combined with Mesalazine in the treatment of ulcerative colitis can effectively improve the therapeutic effect of patients without good safety.It has a good effect on improving the intestinal barrier function of patients with ulcerative colitis,inhibiting the progress of intestinal mucosa,reducing the disease-related impact of patients,and optimizing the quality of life related to gastrointestinal system.It has a positive value in promoting the rehabilitation of gastrointestinal function in patients with ulcerative colitis.
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| [1] |
秦幸茹，赵相轩，闫浩，等.溃疡性结肠炎相关分子机制研究进展[J].中国临床研究，2018，31（4）：558-561.
|
| [2] |
汪海军.免疫肠内营养结合药物治疗溃疡性结肠炎的效果分析[J].实用中西医结合临床，2017，17（11）：128-129.
|
| [3] |
谢燕东，张静瑜，樊晴伶，等.参苓白术散联合复方谷氨酰胺肠溶胶囊对肠易激综合征患者的肠黏膜屏障功能及5-HT、INF-y、IL-8 水平的影响[J].现代生物医学进展，2019，22（14）：4269-4272.
|
| [4] |
郑丽萍，文武.双歧杆菌与复方谷氨酰胺肠溶胶囊联合用药对胃肠功能紊乱患者肠黏膜屏障功能以及炎症因子的影响[J].四川生理科学杂志，2018，40（2）：102-105.
|
| [5] |
中华医学会消化病学分会炎症性肠病学组.炎症性肠病诊断与治疗的共识意见（2018年·北京）[J].中国实用内科杂志，2018，38（9）：796-813.
|
| [6] |
张根红，邹华，黄万平.微生态制剂治疗溃疡性结肠炎[J].牡丹江医学院学报，2017，38（6）：38-40.
|
| [7] |
张伟，杨银利，张林，等.青柏溃结汤灌肠对溃疡性结肠炎大肠湿热证患者结肠黏膜愈合及血清炎性因子水平的影响[J].新乡医学院学报，2018，35（6）：474-477.
|
| [8] |
愈媛，王卿华，陈媛洁，等.痛泻要方对溃疡性结肠炎患者免疫功能及肠道黏膜屏障的调节作用[J].中国中西医结合消化杂志，2020，28（11）：858-862.
|
| [9] |
博茂林，薛芝兰，张涛.3 种益生菌制剂联合美沙拉嗪口服治疗轻中度溃疡性结肠炎疗效[J].武警医学，2017，28（10）：980-984.
|
| [10] |
董显文，黄莎，黄诗良，等.亚洲炎症性肠病患者TPMT基因突变增加嘌呤类药物不良反应的Meta 分析[J].浙江医学，2019，41（10）：1049-1052.
|
| [11] |
姜璐，吴波，郭良清，等.愈溃凉血颗粒联合美沙拉嗪对溃疡性结肠炎患者疗效及肠道屏障功能影响[J].辽宁中医药大学学报，2020，22（4）：139-142.
|
| [12] |
张海平，陈培俊.布拉酵母联合美沙拉嗪对溃疡性结肠炎患者氧化应激的影响及疗效观察[J].中国微生态学杂志，2018，30（11）：1297-1299.
|
| [13] |
易国栋，周翔禹，向兴朝，等.双歧杆菌三联活菌胶囊、复方谷氨酰胺肠溶胶囊联合美沙拉嗪对溃疡性结肠炎的疗效观察[J].临床消化病杂志，2017，29（3）：139-143.
|
| [14] |
韩惠萍，张丽娇，董洁晨，等.复方谷氨酰胺肠溶胶囊联合葛根芩连汤防治晚期结直肠癌FOLFIRI 方案化疗相关性腹泻疗效及对肠黏膜通透性和免疫细胞因子的影响[J].现代中西医结合杂志，2017（33）：3669-3673.
|
| [15] |
丙氨酰谷氨酰胺对重型颅脑损伤患者肠黏膜通透性和血浆二胺氧化酶的研究[J].检验医学与临床，2018，15（4）：485-487.
|
| [16] |
宋晓兵，吴庆荣，吴奇明，等.营养支持小组的建立及对我院丙氨酰谷氨酰胺注射液的干预效果研究[J].中国当代医药，2020，27（28）：163-166.
|
|
|
|
