尼可地尔治疗冠心病不稳定型心绞痛的临床效果及安全性研究

Abstract
Figure/Table
References (18)
Related Citation (15)

Download: PDF (440 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To explore the clinical efficacy and safety of Nicorandil in patients with unstable angina pectoris of coronary heart disease.Methods From October 2019 to September 2020,82 patients with unstable angina of coronary heart disease in Nanping First Hospital were selected as the research objects,and they were divided into a control group and a study group (with 41 cases each) using the random number table method.Patients in the control group were treated with conventional treatment,and patients in the study group were treated with Nicorandil on the basis of the control group.The clinical efficacy,the number and duration of angina pectoris,the incidence of adverse reactions,and the incidence of adverse cardiovascular events were compared between the two groups of patients.Results The total effective rate of treatment in the study group was higher than that in the control group,the difference was statistically significant (P＜0.05).There was no significant difference in the number and duration of angina pectoris before treatment between the two groups (P＞0.05).The number and duration of angina pectoris after treatment in the two groups were lower than those before treatment,the number and duration of angina pectoris in the study group after treatment were lower than those in the control group,and the differences were statistically significant (P＜0.05).There were no significant difference in the incidence of diarrhea,nausea,vomiting,headache and other adverse reactions between the two groups (P＞0.05),and all the adverse reactions were relieved after symptomatic treatment.There was no significant difference in the incidence of adverse cardiovascular events between the two groups (P＞0.05).Conclusion Nicorandil treatment for patients with unstable angina pectoris of coronary heart disease can significantly improve the symptoms of chest tightness,chest pain,fatigue and other symptoms,relieve the onset of angina pectoris,improve myocardial ischemia,and exert significant clinical effects.

Key words： Nicorandil Coronary heart disease Unstable angina pectoris Clinical effect Safety

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	JIANG Ling
	WU Yuxian
	SHEN Xuebin

Cite this article:

JIANG Ling,WU Yuxian,SHEN Xuebin. Clinical effect and safety of Nicorandil in the treatment of unstable angina pectoris of coronary heart disease[J]. 中国当代医药, 2022, 29(7): 53-56.

URL:

https://www.dangdaiyiyao.com/EN/ OR https://www.dangdaiyiyao.com/EN/Y2022/V29/I7/53

[1]	杨慧.尼可地尔对高龄冠心病不稳定型心绞痛患者临床疗效探讨[J].中国冶金工业医学杂志，2020，37（5）：492.
[2]	赵春妍，张钿.尼可地尔对高龄冠心病不稳定型心绞痛患者临床疗效价值[J].中国卫生标准管理，2020，11（10）：68-70.
[3]	赵莉莉.尼可地尔治疗冠心病不稳定型心绞痛的临床效果观察[J].黑龙江科学，2019，10（24）：70-71.
[4]	林华，王媛媛，郗昆，等.尼可地尔治疗冠心病不稳定型心绞痛的临床疗效[J].当代医学，2019，25（31）：34-36.
[5]	姚璐，武云涛，田国祥，等.尼可地尔对老年冠心病稳定型心绞痛合并糖尿病患者的临床观察[J].中国循证心血管医学杂志，2019，11（7）：807-810.
[6]	林添海，刘丰，张韶冈，等.酒石酸美托洛尔治疗老年冠心病不稳定型心绞痛患者的临床疗效及其对血清脑利钠肽和可溶性细胞间黏附分子1 水平的影响[J].实用心脑肺血管病杂志，2017，25（9）：152-154.
[7]	孟宪磊，任建明，刘振华.尼可地尔治疗不稳定型心绞痛的疗效及安全性评价[J].临床研究，2019，27（5）：34-35.
[8]	刘宏煜.尼可地尔治疗不稳定型心绞痛的效果及安全性评价[J].临床研究，2019，27（2）：96-97.
[9]	张青雯.尼可地尔治疗冠心病稳定型心绞痛合并糖尿病临床效果观察[J].糖尿病新世界，2019，22（2）：15-17.
[10]	全勇，张育民，李峰，等.尼可地尔治疗冠心病稳定型心绞痛合并糖尿病效果观察[J].中国卫生标准管理，2018，9（16）：97-99.
[11]	伍灏堃，樊婷，赵一俏.卡维地洛联合红花黄色素氯化钠注射液对冠心病不稳定型心绞痛患者的影响[J].实用心脑肺血管病杂志，2017，25（12）：162-164.
[12]	张嵚垚，马淑梅.静脉注射尼可地尔对行经皮冠状动脉介入治疗的不稳定性心绞痛患者的心肌保护作用[J].实用药物与临床，2020，23（1）：38-42.
[13]	全勇，张育民，李峰，等.阿托伐他汀钙联合尼可地尔治疗不稳定性心绞痛的临床疗效分析[J].中国处方药，2018，16（6）：74-75.
[14]	吴春兴，王小芳，谢斐.尼可地尔联合参麦注射液治疗不稳定性心绞痛合并2 型糖尿病疗效观察[J].医学临床研究，2018，35（11）：2215-2217.
[15]	于凝，惠永明，马超.尼可地尔对高龄冠心病不稳定型心绞痛患者临床疗效分析[J].解放军预防医学杂志，2019，37（5）：29-30.
[16]	孙喜文，陈海坚，莫荣浩,等.左西孟旦联合尼可地尔对缺血性心肌病伴顽固性心力衰竭疗效观察[J].中国医学创新，2021，18（26）：137-140.
[17]	田文建，连亦田.尼可地尔治疗老年不稳定性心绞痛患者的效果[J].中外医学研究，2021，19（22）：25-28.
[18]	李琳，秦保健.美托洛尔联合地尔硫卓对冠心病不稳定型心绞痛患者的疗效观察[J].国际医药卫生导报，2017，23（13）：2073-2074.