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Quick Search     Adv Search 2024 Vol. 31, No. 17 Published: 2024-06-18   4 Effect of mesenchymal stem cell exosomes to neurological function recovery of rats with ischemic stroke LIU Junpeng LI Yunfei LI Yongkun Objective To discuss the effect of mesenchymal stem cell exosomes (MSCs-EXO)to neurological function recovery of rats with ischemic stroke.Methods Rat bone marrow mesenchymal stem cells were cultured in primary culture,MSCs-EXO were extracted by hyperspeed centrifuge method,and the rat ischemic stroke model was made by middle cerebral artery occlusion(MCAO)method,the MSCs-EXO were administered nasally and were set as MSCs-EXO treated group,and the neural function recovery was evaluated by modified neurological severity scores(mNSS)and misstep test,and compared with the untreated model group (MCAO group).The distribution of MSCs-EXO labeled by PKH26 in ischemic penumbra(IP) was observed by immunofluorescence staining.The expression level of PTEN in brain tissue in IP region was detected by fluorescence quantitative PCR and Western blot,and compared with normal rats and MCAO group.Results The recovery of nerve function in the MSCs-EXO treated group was higher than that in the MCAO group,and the difference was statistically significant (P＜0.05).Immunofluorescence staining showed that labeled MSCs-EXO could enter nerve cells in the IP region.Quantitative fluorescent PCR and Western blot detection showed that PTEN levels in both the MSCs-EXO treated group and the MCAO group were higher than normal,but PTEN level in the MSCs-EXO treated group was lower than that in the MCAO group,with statistical significances(P＜0.05).Conclusion MSCs-EXO can promote the recovery of neural function in ischemic stroke rats,which may be related to the down-regulation of PTEN expression in IP region. 2024 Vol. 31 (17): 4-08 [Abstract] ( 7 ) HTML (1 KB)  PDF (1015 KB)  ( 11 ) 9 Clinical characteristics and risk factors of acute myocardial infarction with new atrial fibrillation CHEN Shuo LI Peng FANG Meng XU Jianhui Objective To analyze the clinical characteristics and risk factors of patients with acute myocardial infarction(AMI) with new-onset atrial fibrillation (NOAF).Methods A total of 230 patients with AMI admitted to Xiaogan Central Hospital from May 2021 to February 2022 were selected as the study objects.According to the occurrence of NOAF after AMI,the patients were divided into study group (25 cases in NOAF group) and control group (205 cases in without NOAF).Clinical characteristics of the two groups,such as age,gender,smoking history and hypertension history,were collected.The results of laboratory tests,such as cardiac troponin I (CTNI),brain natriuretic peptide (BNP),C-reactive protein(CRP),the ratio of CRP to serum albumin (CRA),etc.were collected.The results of imaging examinations including left atrial end-diastolic diameter (LAED) and left ventricular end-diastolic dimension (LVEDD) were collected.Multivariate logistic regression was used to analyze the risk factors of NOAF after AMI.Results Univariate analysis showed that there were statistically significant differences in the proportion of hypertension history,BNP,KILLIP grade,CRP,CRA and LAED between NOAF group and control group,and the differences were statistically significant (P＜0.05).Multivariate analysis results indicated that BNP (β=1.423,OR=4.148,95%CI: 1.139～15.099),KILLIP ≥grade Ⅱ(β=1.707,OR=5.515,95%CI:1.017～29.903),CRP (β=2.096,OR=8.132,95%CI:1.541～42.895),CRA (β=2.212,OR=9.136,95% CI:1.159～72.024),LAED (β=2.472,OR=11.851,95%CI:2.571～54.619) were the risk factors for NOAF after AMI(P＜0.05,OR＞1).Conclusion BNP,KILLIP grade≥Ⅱ,CRP,CRA and LAED are risk factors for AMI with NOAF. 2024 Vol. 31 (17): 9-13转21 [Abstract] ( 9 ) HTML (1 KB)  PDF (540 KB)  ( 2 ) 14 Bioinformatic research on pathogenesis of idiopathic pulmonary fibrosis WEI Shuhong Objective To explore the differential expression genes,the core genes and potential mechanisms associated with the pathogenesis of idiopathic pulmonary fibrosis (IPF)based on bioinformatics.Methods The GSE10667,GSE31934 and GSE24206 datasets were downloaded from the Gene Expression Omnibus database of the National Center for Biotechnology Information.The DEGs of IPF were screened,the protein-protein interaction network was constructed,the enrichment analysis and functional cluster analysis were performed in order to screen the core genes,signaling pathways and related microRNAs.Results After screening,a total of 107 DGEs in IPF were obtained,CXCL12,ACAN,IGF1,CXCL8,CSF2,ICAM1 were the core genes of IPF which enriched in signaling pathways such as transforming growth factor-β,nuclear transcription factor-κB,tumor necrosis factor,interleukin-17,Janus kinase/signal transducer and activator of transcription,phosphatidylinositol-3-kinases/protein-serine-threonine kinase.The miR-4465,miR-182-5p,miR-1297,miR-1252-3p and other microRNAs which were closely related to IPF were obtained by functional cluster analysis.Conclusion There are significant differences in gene expression during the pathogenesis of IPF.The pathological process involves multiple targets and pathways.IPF pathogenesis may be regulated by multiple microRNAs.CXCL12,ACAN,IGF1,CXCL8,CSF2,ICAM1 may be the core genes in the pathogenesis of IPF. 2024 Vol. 31 (17): 14-21 [Abstract] ( 7 ) HTML (1 KB)  PDF (2838 KB)  ( 2 ) 22 Effect of wet compress of Ice Rehabilitation New Solution in the treatment of acute radiation dermatitis YUAN Haizhen LOU Liqiong QIAO Haizhen YANG Shuixiu TANG Zhimou FAN Yue Objective The clinical effect of ice rehabilitation wet therapy on acute radiation dermatitis was analyzed.Methods Sixty patients with acute radiation dermatitis admitted to Jiangxi Provincial People's Hospital from January 2021 to June 2023 were selected as the study subjects,and they were divided into control group and experimental group using the random number table method,with 30 patients in each group.The control group was treated with normal Saline +Gentamicin+Dexamethasone+Vitamin B12,and the test group was treated with wet compress of Ice Rehabilitation New Solution.The treatment response rate,pain score,onset time and healing time were compared between the two groups.Results The clinical effect of experimental group was better than that of control group,and the difference was statistically significant(P＜0.05).The visual analogue scale(VAS)score of experimental group was lower than that of control group after treatment,and the difference was statistically significant (P＜0.05).The onset time and healing time of experimental group after treatment were shorter than that of control group,and the frequency of dressing change was less than that of control group,with statistical significances(P＜0.05).Conclusion The patients with acute radiation dermatitis have a better clinical effect than conventional treatment,which can effectively promote the recovery of skin damage and reduce the pain of patients,which is worthy of research and promotion. 2024 Vol. 31 (17): 22-25 [Abstract] ( 8 ) HTML (1 KB)  PDF (558 KB)  ( 5 ) 26 Application value of endoscopic retrograde appendicitis therapy in pediatric appendicitis ZENG Ling Objective To explore the value of endoscopic retrograde appendicitistherapy (ERAT)in pediatric appendicitis.Methods A total of 60 children with acute simple appendicitis admitted to Ganzhou People's Hospital from January 2021 to June 2022 were selected as subjects,and they were divided into experimental group (n=30)and control group (n=30)according to random number table method.The control group received antibiotic treatment,while the experimental group received ERAT treatment.The relevant time indicators,incidence of complications,and white blood cell levels before and after treatment were compared between the two groups.Results Symptom relief time,white blood cell recovery time,body temperature recovery time and hospitalization time of test group were shorter than those of control group,the differences were statistically significant(P＜0.05).There was no significant difference in the total incidence of complications between the experimental group and the control group (P＞0.05).The leukocyte level of experimental group was lower than that of control group 1 day after treatment,and the difference was statistically significant (P＜0.05).The recurrence rate of experimental group was lower than that of control group,and the difference was statistically significant(P＜0.05).Conclusion The application of endoscopic retrograde appendicitis treatment scheme in the treatment of simple appendicitis in children has significant effects on promoting rapid remission of symptoms and shortening the hospital stay of children,and can effectively reduce the recurrence rate of children. 2024 Vol. 31 (17): 26-29 [Abstract] ( 9 ) HTML (1 KB)  PDF (559 KB)  ( 0 ) 30 Clinical effect of Aluminum Magnesium Marbonate combined with Esomeprazole in the treatment of patients with gastric ulcer accompanied with bleeding HAN Huide Objective To analyze the value of Aluminum Magnesium Marbonate combined with Esomeprazole in the treatment of acute gastric ulcer with bleeding.Methods A total of 128 patients with acute gastric ulcer accompanied with bleeding admitted to Jinan Third People's Hospital from June 2021 to June 2023 were selected as the study objects,and they were divided into control group and observation group according to random number table method,with 64 cases in each group.The control group was treated with Esomeprazole,and the observation group was treated with Aluminum Magnesium Carbonate.The indexes of gastric ulcer mucosa healing,symptom score and incidence of adverse reactions were compared between the two groups.Results After treatment,the levels of vascular endothelial growth factor (VEGF),cyclooxygenase(COX)and epidermal growth factor (EGF)in observation group were higher than those in control group,and the differences were statistically significant(P＜0.05).After treatment,the scores of abdominal pain,pantothenic acid,abdominal distension and belching in observation group were lower than those in control group,and the differences were statistically significant(P＜0.05).The incidence of adverse reactions in observation group was lower than that in control group,and the difference was statistically significant (P＜0.05).After treatment,the levels of interleukin-6 (IL-6),interleukin-8 (IL-8),interleukin-23(IL-23)and tumor necrosis factor-α(TNF-α)in observation group were lower than those in control group,and the differences were statistically significant (P＜0.05).The blood transfusion volume in the observation group was less than that in the control group,and the hemostasis time,hematemesis time and hematochezia time in the observation group were shorter than those in the control group,and the differences were statistically significant (P＜0.05).Conclusion Aluminum Magnesium Carbonate combined with Esomeprazole is effective in the treatment of patients with acute gastric ulcer with bleeding.The mucosal indexes of gastric ulcer tend to be normal,and the symptoms are significantly improved,which can be used for reference and promotion in clinical practice. 2024 Vol. 31 (17): 30-33转37 [Abstract] ( 7 ) HTML (1 KB)  PDF (570 KB)  ( 8 ) 34 Comparison of the application effect of Phloroglucinol and Anisodamine in emergency renal colic patients MING Hao1 LIN Yunqing2 SHU Min3 Objective To explore the comparison of the application effects of Phloroglucinol and Anisodamine in emergency renal colic patients.Methods A total of 86 patients with renal colic admitted to the emergency department of Huazhong University of Science and Technology Shenzhen Hospital from March 2022 to September 2023 were selected as the study subjects.They were divided into control group(43 cases)and observation group(43 cases)by random number table method.The control group was treated with Sustained-Release Diclofenac Sodium Tablets and Anisodamine,while the study group was treated with Sustained-Release Diclofenac Sodium Tablets and Phloroglucinol.The clinical efficacy,pain severity(visual analogue scale [VAS]score),pain relief time,analgesic onset time,incidence of adverse reactions,and 24-hour recurrence rate were compared between two groups.Results The total effective rate of the research group was higher than that of the control group,and the differences was statistically significant (P＜0.05).The VAS score of the study group after treatment was lower than that of the control group,and the difference was statistically significant (P＜0.05).The pain relief time and analgesic effect time of the research group were shorter than those of the control group,and the differences were statistically significant (P＜0.05).The total incidence of adverse reactions in the study group was lower than that in the control group,and the difference was statistically significant (P＜0.05).The 24-hour recurrence rate in the study group was lower than that in the control group,and the difference was statistically significant (P＜0.05).Conclusion As a new type of antispasmodic and analgesic drug,Anisodamine has a faster onset of action,significant antispasmodic and analgesic effects,smaller side effects,higher safety,and clinical application value compared to Anisodamine. 2024 Vol. 31 (17): 34-37 [Abstract] ( 7 ) HTML (1 KB)  PDF (560 KB)  ( 11 ) 38 Correlation analysis of serum lipoprotein-associated phospholipase A2 with clinical features and prognosis in patients with coronary heart disease combined with hypertension LIU Gao1 WU Zhiqing2 HUANG Xingzhi3 Objective To explore the influencing factors of coronary heart disease complicated with hypertension.Methods A total of 60 patients with coronary heart disease combined with hypertension from December 2019 to December 2021 in Pingxiang People's Hospital were selected as the observation group and 60 patients with simple coronary heart disease were selected as the control group.The basic and clinical data of the two groups were compared to analyze the risk factors of coronary heart disease combined with hypertension.Results There were no significant differences in occupational and educational level between the two groups (P＞0.05).The proportion of age≥65 years old,smoking,pulse pressure＞40 mmHg and serum lipoprotein-associated phospholipase A2 (Lp-PLA2)＞175 ng/ml in observation group were higher than thosein control group,and the differences were statistically significant(P＜0.05).Multivariate analysis showed that patients'age≥65 years old(β=1.121,OR=4.157,95%CI=2.186-5.499),smoking(β=1.341,OR=2.103,95%CI=1.472-3.284),pulse pressure＞40 mmHg (β=1.127,OR=3.861,95%CI=2.049-4.867),and serum Lp-PLA2 level＞175 ng/ml (β=1.378,OR=1.984,95%CI=1.453-3.241)were independent risk factors for coronary heart disease combined with hypertension(P＜0.05).Conclusion Age≥65 years old,smoking,pulse pressure＞40 mmHg and serum Lp-PLA2 level＞175 ng/ml are independent risk factors of coronary heart disease combined with hypertension,which can provide accurate theoretical basis for early non-invasive prediction of clinical features and prognosis of coronary heart disease combined with hypertension. 2024 Vol. 31 (17): 38-41 [Abstract] ( 8 ) HTML (1 KB)  PDF (381 KB)  ( 27 ) 42 Evaluation of the effect of sequential recanalization intervention therapy on electrocardiogram in elderly patients with acute myocardial infarction ZHANG Ying QI Yunling Objective To analyze the value of sequential recanalization interventional therapy for senile acute myocardial infarction.Methods A total of 86 elderly patients with acute myocardial infarction admitted to Shandong Guoxin Health Care Group Zaozhuang Central Hospital from August 2022 to August 2023 were selected as the study objects.According to the order of admission,they were divided into conventional group (43 cases admitted first)and sequential group (43 cases admitted later).The conventional group received routine interventional treatment,and the sequential group received sequential recanalization intervention therapy.Electrocardiogram indexes,cardiac function,biochemical indexes and incidence of QRS burst were compared between the two groups.Results Before intervention,there were no significant differences in electrocardiogram indexes between the two groups (P＞0.05).After intervention,the electrocardiogram indexes of the two groups were higher than those before intervention,and the electrocardiogram indexes of the sequential group were higher than those of the conventional group,with statistical significances (P＜0.05).Before intervention,there were no significant differences in cardiac function indexes between the two groups (P ＞0.05).After intervention,the left ventricular ejection fraction(LVEF)and left ventricular end-systolic diameter(LVESD)of the two groups were higher than those before intervention,and the left ventricular end-diastolic diameter (LVEDD) of the two groups were lower than those before intervention,and the LVEF and LVESD of the sequential group were higher than those of the conventional group,and the LVEDD of the sequential group was lower than that of the conventional group,with statistical significances (P＜0.05).Before intervention,there were no significant differences in biochemical indexes between the two groups (P＞0.05).After intervention,the levels of matrix metalloproteinase 9 (MMP-9)and cystatin C in two groups were lower than those before intervention,and thelevels of MMP-9 and cystatin C in the sequential group were lower than those in the conventional group,with statistical significances (P＜0.05).There was no significant difference in the incidence of QRS burst before intervention between the two groups (P＞0.05).The incidence of QRS burst after intervention in sequential group was lower than that in conventional group,and the difference was statistically significant(P＜0.05).Conclusion Sequential recanalization interventional therapy can regulate MMP-9,restore myocardial blood flow,improve cardiac function,effectively reduce QRS burst events,and improve the prognosis of senile acute myocardial infarction. 2024 Vol. 31 (17): 42-45转50 [Abstract] ( 7 ) HTML (1 KB)  PDF (956 KB)  ( 5 ) 46 Clinical efficacy of repetitive transcranial magnetic stimulation in patients with dysphagia in stroke YANG Huajun ZHANG Yingzheng HU Saiqin ZHENG Yingtao LIN Xiang YIN Lufeng Objective To explore the clinical therapeutic effects of repetitive transcranial magnetic stimulation (rTMS) on normal and affected cerebral hemispheres of patients with dysphagia after stroke.Methods A total of sixty patients with dysphagia after stroke who were admitted to the Third People's Hospital Affiliated to Fujian University of Chinese Medicine from October 2019 to October 2022 were selected as the study objects.According to random number table method,they were divided into control group(20 cases),trial group A(20 cases)and trial group B(20 cases).The control group received conventional dysphagia treatment,and 5 Hz rTMS was applied to the affected or unaffected area on the basis of conventional treatment in the test A and test B groups,respectively,and both intervened for 3 weeks.The clinical swallowing function and inflammatory factor changes in each group before and after the intervention were assessed by measuring serum inflammatory factors and using the fiberoptic endoscopic dysphagia severity scale(FEDSS),the penetration aspiration scale(PAS),and the standardized swallowing assessment(SSA).Results After intervention,FEDSS,PAS and SSA scores of trial group A and trial group B were lower than those of control group,with statistical significance(P＜0.05).There was no significant difference in FEDSS,PAS and SSA scores between trial group A and trial group B(P＞0.05).The levels of interferon-γ,tumor necrosis factor-α and interleukin 6 in trial group A were lower than those in trial group B and control group,and the difference was statistically significant(P＜0.05),while only interferon-γ in trial group B was lower than that in control group,and the difference was statistically significant(P＜0.05).Conclusion 5 Hz high-frequency rTMS stimulation of normal and affected hemispheres has positive effects on post-stroke dysphagia patients,but stimulation of the affected area is more advantageous for improving the expression of inflammatory factors in patients. 2024 Vol. 31 (17): 46-50 [Abstract] ( 7 ) HTML (1 KB)  PDF (459 KB)  ( 5 ) 51 Effect of puzzle opening acupuncture combined with Eight Section Brocade exercise on neurological and cognitive function in patients with cognitive impairment after stroke XIONG Jia1 PENG Tianzhong2 ZHOU Cheng1▲ Objective To analyze the effect of the combination of puzzle opening acupuncture and Eight Section Brocade exercise on the neurological and cognitive functions of patients with cognitive impairment after stroke.Methods A total of 80 patients with post-stroke cognitive impairment admitted to Nanchang Hongdu Hospital of Traditional Chinese Medicine from January to September 2023 were selected as the research subjects.According to the random number table method,the control group and the study group were divided into 40 cases each.The control group underwent Eight Section Brocade exercise,while the study group received puzzle opening acupuncture treatment on the basis of the control group.The neurological function,daily living ability,cognitive function,neurotransmitter levels,hemorheological indicators,and clinical efficacy of the two groups of patients were observed.Results After treatment,the levels of the National Institutes of Health Stroke scale(NIHSS),erythrocyte sedimentation rate(ESR),hematocrit(HCT),and whole blood viscosity(WBV)in the study group were lower than those in the control group,the Berg balance scale(BBS)score,activities of daily living(ADL),brief mental state examination (MMSE),Montreal cognitive assessment scale (MoCA) score,dopamine (DA),and serotonin (5-HT) were also lower than those in the control group,the level of norepinephrine(NE)was higher than that of the control group,and the differences were statistically significant(P＜0.05).Conclusion The use of puzzle opening acupuncture and the combination of Eight Section Brocade exercise therapy can improve the patient's neurological function,enhance their cognitive function,enhance their daily living ability,promote their recovery,and achieve good results. 2024 Vol. 31 (17): 51-55 [Abstract] ( 8 ) HTML (1 KB)  PDF (487 KB)  ( 9 ) 56 Analysis of influencing factors of pain and knee function in female knee osteoarthritis WANG Jing1 ZHAI Xinxiang1 YANG Qi2 ZHANG Min3 DU Jiong3 Objective To explore the status quo of female patients with knee osteoarthritis and analyze the influence of different factors on the degree of knee pain and knee function.Methods A total of 449 female patients with knee osteoarthritis who were admitted to Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine and Xishan District Traditional Chinese Medicine Hospital of Wuxi from January 2020 to December 2022 were studied.The effects of age,course of disease,Body mass index,abortion history and pregnancy history on knee osteoarthritis pain were analyzed.The effects of different pregnancy times and abortion times on knee osteoarthritis pain and knee function were compared.Results The increase of pregnancy,abortion and age were the aggravating factors (P＜0.05).The increased number of pregnancies,the increased number of abortions and the increase of age were also the factors affecting the knee function of female knee osteoarthritis (P＜0.05).Conclusion Pregnancy,abortion and age are important factors leading to pain and decreased knee function of female knee osteoarthritis,and it is necessary to pay attention to its influence and related factors management in clinical diagnosis and treatment. 2024 Vol. 31 (17): 56-59 [Abstract] ( 8 ) HTML (1 KB)  PDF (543 KB)  ( 5 ) 60 Clinical effect of the treatment of cervical-type cervical spondylosis with Guizhi and Gegen Decoction combined with therapy of rod point-pressing LIU Tongming LIU Ming HUANG Dunsheng LYU Shuguang Objective To observe the therapeutic effect of Guizhi and Gegen Decoction combined with therapy of rod point-pressing on cervical spondylosis.Methods A total of 120 patients with cervical spondylosis treated in the Department of Orthopedics and Traumatology,Bozhou Hospital of Traditional Chinese Medicine from January 2022 to January 2023 were selected as the research objects and divided into control group 1(40 cases),control group 2(40 cases)and observation group(40 cases) according to random number table method.The patients in control group 1 were treated with Guizhi and Gegen Decoction orally,1 dose once a day,in the morning and evening,for 2 weeks.The patients in the control group 2 were treated with rod point-pressing technique therapy,once every 3 days for 2 weeks.The observation group was treated with Guizhi and Gegen Decoction combination with rod point-pressing technique therapy for 2 weeks.The visual analogue scale(VAS),neck disability index (NDI)and clinical efficacy of the three groups were compared before and after treatment.Results The VAS score and NDI function score of the three groups after treatment were lower than before treatment in the same group,the differences were statistically significant (P＜0.05),and the VAS score and NDI function score of the observation group were lower than those of control group 1 and control group 2,the differences were statistically significant (P＜0.05).The curative effect of observation group was better than control group 1 and control group 2,and the difference was statistically significant(P＜0.017).Conclusion Guizhi and Gegen Decoction combined with rod point-pressing technique therapy can significantly improve the clinical symptoms,relieve pain and improve the cervical spine function of cervical-type cervical spondylosis. 2024 Vol. 31 (17): 60-64 [Abstract] ( 8 ) HTML (1 KB)  PDF (550 KB)  ( 6 ) 65 Comparison of total knee arthroplasty and arthroscopic minimally invasive debridement in the treatment of senile knee osteoarthritis CHEN Mingwei Objective To explore the clinical efficacy of total knee arthroplasty (TKA)and arthroscopic minimally invasive debridement in the treatment of senile knee osteoarthritis.Methods A total of 110 elderly patients with knee arthritis who underwent surgical treatment in the Fifth Affiliated Hospital of Sun Yat-sen University from March 2018 to March 2023 were selected as the observation objects,and divided into control group and study group according to the lottery method,with 55 patients in each group.The control group were treated with arthroscopic minimally invasive debridement,while the study group were treated with TKA.The excellent and good rate of surgical treatment,the degree of joint pain before and after operation,osteoarthritis index,knee joint dysfunction and improvement of quality of life were compared between the two groups.Results Six months after operation,the excellent and good rate of surgical treatment in the study group was higher than that in the control group,with statistical significance(P＜0.05).The visual analogue scale(VAS)score and the Western Ontario and McMaster Universities(WOMAC)of the patients in the study group were lower than those in the control group at 6 months after operation,the scores of Hospital for Special Surgary (HSS) and arthritis impact measurement scale (AIMS)were higher than those in the control group,and the difference were statistically significant (P＜0.05).Three months after operation,the active flexion angle of knee joint in the study group was higher than that in the control group,and the varus angle was lower than that in the control group,with statistical significances (P＜0.05).Conclusion TKA is effective in the treatment of knee osteoarthritis in the elderly,which has obvious advantages in improving knee joint function,improving kinematics parameters,reducing joint pain and osteoarthritis index,effectively reducing the impact of diseases on patients'quality of life,and has high clinical application value. 2024 Vol. 31 (17): 65-69 [Abstract] ( 8 ) HTML (1 KB)  PDF (579 KB)  ( 9 ) 70 Application effect of ultrasound combined with mobilization with movement in the treatment of lateral epicondylitis WU Lijian1 LIN Hanyan2 Objective To observe the therapeutic effect of ultrasound combined with mobilization with movement on lateral epicondylitis and compare it with ultrasound alone.Methods Fifty patients diagnosed with lateral epicondylitis admitted to the Department of Orthopedics and Rehabilitation Medicine of Quanzhou First Hospital from March 2021 to March 2023 were selected as the study objects,and they were divided into control group (n=25)and treatment group (n=25)by random number table method.The control group was treated with conventional ultrasound,and the treatment group was combined with mobilization with movement on the basis of the control group.Both groups were treated for 2 weeks.Pain visual analogue scale(VAS),pain-free grip strength test(PFG)and the patient-rated tennis elbow evaluation(PRTEE)were compared between the two groups.Results Before treatment,there was no significant difference in VAS score,PRTEE score and PFG value between the two groups(P＞0.05).After treatment,the VAS score and PRTEE score of the treatment group were lower than those of the control group,and the differences were statistically significant (P＜0.05),the PFG value in the treatment group was higher than that in the control group,and the difference was statistically significant (P＜0.05).After treatment,VAS score and PRTEE score of the two groups were lower than before treatment,PFG value was higher than before treatment,the differences were statistically significant (P＜0.05).Conclusion The treatment of lateral epicondylitis with ultrasound alone or combined mobilization with movement can improve the VAS score,PRTEE score and PFG score of patients,but the efficacy of ultrasound combined mobilization with movement is significantly better than that of ultrasound alone,which is suitable for clinical promotion. 2024 Vol. 31 (17): 70-73 [Abstract] ( 7 ) HTML (1 KB)  PDF (542 KB)  ( 10 ) 74 Clinical effect of iRoot SP single-tip filling technique for root canal retreatment ZHONG Yuan1 DAI Lixia2 Objective To explore the clinical effect of iRoot SP single-tip filling technique for root canal retreatment.Methods A total of 96 patients who underwent root canal retreatment in Changsha Stomatological Hospital from February 2021 to January 2022 were selected as the research objects.According to random number table method,they were divided into study group(n=48)and reference group(n=48).The study group was filled with iRoot SP single-tip,and the reference group was filled with AH-Plus hot gutta-percha vertical compression method.The effect of root canal filling,single root canal filling time,pain degree,curative effect and masticatory function were compared between the two groups.Results There was no significant difference in the effect of root canal filling between the two groups (P＞0.05).The filling time of single root canal in the study group was(58.88±5.21)s,which was shorter than(92.35±7.24)s in the reference group,and the difference was statistically significant(P＜0.05).The visual analogue scale(VAS)scores of the study group were(4.28±0.79)points and(2.97±0.35)points,both lower than(6.54±2.02)points and(3.87±1.21)points of the reference group,and the differences were statistically significant(P＜0.05).There were no significant differences in the efficacy and total effective rate between the two groups(P＞0.05).After operation,the masticatory efficiency and bite force of the two groups were higher than those before operation,and the masticatory efficiency and bite force of the study group were higher than those of the reference group,and the differences were statistically significant (P＜0.05).Conclusion The application of iRoot SP single-tip filling technique in root canal retreatment can ensure the curative effect,shorten the filling time,relieve the pain of patients,and improve the masticatory function,which is worthy of clinical application. 2024 Vol. 31 (17): 74-77转82 [Abstract] ( 7 ) HTML (1 KB)  PDF (523 KB)  ( 1 ) 78 Clinical effect of tonifying kidney and promoting blood circulation method combined with Mecobalamine Tablets in intervention of glaucoma after intraocular pressure control WANG Tao HE Xiaozhang LAN Ting HE Qiong HE Jianzhong LAI Wei QIU Yanfei Objective To investigate the safety and efficacy of tonifying kidney and promoting blood circulation method combined with Mecobalamin Tablets in the treatment of glaucoma after intraocular pressure control,and to provide more clinical means and ideas for the treatment of glaucoma after intraocular pressure control with integrated traditional Chinese and western medicine.Methods A total of 60 patients diagnosed as glaucoma after intraocular pressure control in the Department of Ophthalmology,Pingxiang People's Hospital from January 2018 to December 2022 were selected as the study objects.According to the order of treatment,the patients were divided into treatment group (30 cases) and control group(30 cases).The control group was given Mecobalamine Tablets orally only.On the basis of the control group,the treatment group was given oral tonifying kidney and promoting blood circulation traditional Chinese medicine.Both groups were treated for 3 months.The changes of visual acuity,intraocular pressure,visual field and traditional Chinese medicine syndrome score were compared between the two groups.Results Twenty-eight patients (45 eyes)in the control group and 26 patients(44 eyes) in the treatment group completed the observation.There were no significant differences in intraocular pressure and visual acuity between the two groups before and after treatment (P＞0.05).The vision mean sensitivity (MS)of the two groups after treatment were higher than those before treatment,and the differences were statistically significant (P＜0.05).The mean defect(MD),loss variance(LV),visual field defect scores and traditional Chinese medicine syndrome scores of the treatment group after treatment were lower than those before treatment,and the differences were statistically significant(P＜0.05).There were no statistically significant differences in MD,LV,visual field defect scores and traditional Chinese medicine syndrome scores in the control group before and after treatment(P＞0.05).Conclusion Tonifying kidney and promoting blood circulation method combined with Mecobalamin Tablets in the treatment of glaucoma after intraocular pressure control is helpful to improve visual acuity and visual sensitivity,effectively control visual field defects,improve the symptoms of traditional Chinese medicine,and provide a new idea for the protection of visual function in patients with glaucoma after intraocular pressure control. 2024 Vol. 31 (17): 78-82 [Abstract] ( 9 ) HTML (1 KB)  PDF (514 KB)  ( 6 ) 83 Effect of femtosecond laser assisted cataract surgery and conventional phacoemulsification cataract surgery on intraocular pressure,best corrected visual acuity,and optic disc blood flow density in patients with age-related cataract patients REN Xuan1 LAI Mengyun1 CHEN Tingting2 Objective To compare the effect of femtosecond laser assisted cataract surgery(FLACS)and conventional phacoemulsification cataract surgery(CPCS)on intraocular pressure,best corrected visual acuity,and optic disc blood flow density in patients with age-related cataract (ARC)patients.Methods A total of 70 ARC patients admitted to Nanchang Aier Eye Hospital from July 2021 to July 2023 were selected as the research objects,and they were divided into control group(35 cases) and observation group (35 cases) according to the random number table method.The control group was treated with CPCS,and the observation group was treated with FLACS.Both groups were followed up for 3 months.The operation-related indicators,intraocular pressure,central macular thickness (CMT),best corrected visual acuity (BCVA),blood flow density in the optic disc area,and complications were compared between the two groups.Results The time of phacoemulsification in the observation group was (14.57±2.30)min,shorter than (22.49±3.58)min in the control group,the energy of phacoemulsification in the observation group was (5.39±1.20) ml,lower than (11.33±2.15) ml in the control group,and the total incidence of complications in the observation group was 5.71% (2/35),less than 22.86%in the control group (8/35),with statistically significant differences (P＜0.05).The results of repeated measures analysis of variance showed that the BCVA time and inter-group comparison before operation,1 day after operation,1 week after operation,1 month and 3 months after operation between the twogroups were statistically significant (P＜0.05),while the interaction between the two groups was not statistically significant(P＞0.05).The BCVA of the two groups at 1 day,1 week,1 month and 3 months after operation were higher than those before operation,and the differences were statistically significant (P＜0.05).There were no significant differences in the time,inter-group and interaction of intraocular pressure,CMT,peripapillary blood flow density,intrapapillary blood flow density between the two groups at each time point before and after operation(P＞0.05).Conclusion FLACS has shorter phacoemulsification time,less emulsification energy,and can improve visual acuity without increasing the influence of intraocular pressure,optic disc blood flow density and CMT,and has fewer complications. 2024 Vol. 31 (17): 83-86 [Abstract] ( 9 ) HTML (1 KB)  PDF (508 KB)  ( 6 ) 87 Value of color Doppler multimodal elastography in differential diagnosis of BI-RADS 3 and 4a breast lesions GAO Jun KE Pei▲ CAO Ying Objective To explore the value of color Doppler multimodal elastography technology in the differential diagnosis of breast imaging report and data system (BI-RADS)Class 3 and 4a breast lesions.Methods A total of sixty patients with BI-RADS 3 and 4a breast masses admitted to Jiujiang Hospital of Traditional Chinese Medicine from April 2022 to April 2023 were selected as the study objects,all of whom underwent color Doppler multimodal elastography examination.The ultrasound characteristics and ultrasound elastography indicators of BI-RADS 3 and 4a breast lesions were analyzed,and surgical pathological biopsy results as the gold standard were used to analyze the diagnostic value of color Doppler multimodal elastography technology and its correlation with pathological diagnosis.Results Among the 60 patients with breast masses,42 were benign masses and 18 were malignant masses.Malignant masses exhibit non parallel growth,irregular edges,uneven internal echoes,and a higher proportion of calcification compared to benign masses,with significant differences (P＜0.05).The elastic index,elastic imaging score,and the area ratio between elastic and grayscale images of malignant tumors were higher than those of benign tumors,with significant differences (P＜0.05).The sensitivity,specificity,positive predictive value,accuracy,and negative predictive value of color Doppler ultrasound multimodal elastography in the diagnosis of BI-RADS 3 and 4a breast lesions were 90.48%,77.78%,90.48%,86.67%,and 77.78%,respectively.Kappa test showed a positive correlation between the diagnostic results of color Doppler multimodal elastography and pathological diagnosis(Kappa=0.683,P＜0.001).Conclusion Color Doppler multimodal elastic imaging technology has high clinical value in the diagnosis of benign and malignant breast lesions in BI-RADS 3 and 4a categories.The diagnostic results are consistent with pathological diagnosis and can provide guidance for clinical diagnosis and treatment of breast masses. 2024 Vol. 31 (17): 87-90 [Abstract] ( 8 ) HTML (1 KB)  PDF (449 KB)  ( 6 ) 91 Evaluation of value of perinatal intracranial vascular ultrasound on predicting short stature KANG Yanting1 HE Min1 LIU Li2 TANG Xiaoyan1 Objective To evaluate the value of perinatal intracranial vascular ultrasound on predicting short stature.Methods A total of 50 children who performed normal prenatal examination and perinatal (late pregnancy,neonatal period)intracranial vascular ultrasound examination and were confirmed as short stature by growth hormone provocation test at 2～6 years after birth in Yichun People's Hospital and Jiangxi Maternal and Child Health Hospital from January 2020 to June 2023 were collected as observation group using retrospective analysis,and 50 children with normal birth height who underwent perinatal intracranial vascular ultrasound examination were collected as control group.The blood flow parameters of middle cerebral artery in the two groups were reviewed in fetal period and neonatal period,including peak systolic velocity(PSV),maximum end-diastolic velocity (EDV),ratio of peak systolic velocity to end-diastolic velocity (S/D)and resistance index(RI),and the value of the above parameters on predicting short stature was analyzed.Results There were no significant differences of the PSV,EDV,RI and S/D of fetal middle cerebral artery in late pregnancy between two groups (P＞0.05).In neonatal period,the PSV and EDV of fetal middle cerebral artery in observation group were lower than those of the control group,and the differences were statistically significant (P＜0.05).The RI of fetal middle cerebral artery was higher than that in control group,with a significant difference(P＜0.05).The blood flow parameters of middle cerebral artery in neonatal period had good efficiency on predicting short stature.The prediction efficiency of middle cerebral artery RI in the neonatal period was the highest.When the cut-off value of middle cerebral artery RI was＞0.71 ml/min,the Youden index,area under the curve (AUC),sensitivity and specificity were 0.637,0.771,76.19%,and 87.50%in predicting short stature.Conclusion The blood flow parameters of middle cerebral artery are abnormal in neonatal period of children with short stature,and the above parameters have good predictive efficiency on short stature and can provide effective guidance for follow-up diagnosis and treatment. 2024 Vol. 31 (17): 91-94 [Abstract] ( 7 ) HTML (1 KB)  PDF (467 KB)  ( 1 ) 95 Application effect of acupoint thread embedding combined with disposable thread embedding needle sweeping in the treatment of simple obesity SONG Siqing1 WANG Jiajia2 QIAN Liping3 Objective To explore the application effect of acupoint thread embedding combined with disposable thread embedding needle sweeping in the treatment of simple obesity.Methods A total of 60 patients with simple obesity admitted to Xinyu Traditional Chinese Medicine Hospital from January 2021 to December 2022 were selected as the study subjects.They were divided into a control group (30 cases)and an observation group (30 cases)according to random number table method.The control group received acupoint thread embedding treatment,while the observation group received acupoint thread embedding combined with disposable thread embedding needle sweeping treatment.The clinical efficacy,weight,hip circumference,waist circumference,body mass index(BMI),and waist-hip ratio(WHR)between the two groups were compared.Results The total effective rate of the observation group was higher than that of the control group,and the difference was statistically significant (P＜0.05).There were no statistically significant differences in body weight,hip circumference,waist circumference,BMI and WHR between the two groups before treatment (P＞0.05).After treatment,the body weight,BMI and WHR of the two groups were lower than those before treatment,and the hip circumference and waist circumference were shorter than those before treatment,and the body weight,BMI and WHR of the observation group were lower than those of the control group,and the hip circumference and waist circumference were shorter than those of the control group,and the differences were statistically significant(P＜0.05).Conclusion The treatment effect of acupoint thread embedding combined with disposable thread embedding needle sweeping is better than that of simple acupoint thread embedding in the treatment of simple obesity,which is more conducive to shortening the waist circumference and hip circumference of patients,reducing the body weight,BMI and WHR. 2024 Vol. 31 (17): 95-98转103 [Abstract] ( 5 ) HTML (1 KB)  PDF (550 KB)  ( 17 ) 99 Professor Feng Xuegong′s experience in clinical application of Wumei Pills WANG Rongmei1 FENG Xuegong2 DING Kan3 Wumei Pills comes from Treatise on Febrile Diseases,and is hailed as ＂the main formula for Jueyin disease＂.Ancient medical practitioners often used it to treat ＂Huijue＂ and ＂Jiuli＂.This prescription is widely used by contemporary doctors to treat a variety of clinical diseases by combining reinforcing and reducing effects and regulating cold and heat.Feng Xuegong,the famous professor of traditional Chinese Medicine in Beijing,studied and inhe rited Mr.Hu Xishu's Syndrome Differentiation of Six Meridians theory,apply the classical prescription.With the clinical practice and observation,he founds that the chronic difficult and complicated diseases often have complex pathological mechanisms of cold,heat,deficiency,and excess.Syndrome Differentiation of Six Meridians is mostly Jueyin disease,and the selection of Wumei Pills can achieve good clinical efficacy.This article selects some of his medical cases and summarizes his experience in using Wumei pills,hoping to broaden the new methods and new ideas for the diagnosis and treatment of chronic and difficult diseases. 2024 Vol. 31 (17): 99-103 [Abstract] ( 7 ) HTML (1 KB)  PDF (553 KB)  ( 18 ) 104 Application effect of Chaihu Shugan Powder combined with Yueju Pills in the treatment of depression and qi depression ZHU Min LI Xiaoping▲ Objective To explore the application effect of Chaihu Shugan Powder combined with Yueju Pills in the treatment of depression and qi depression.Methods A total of 90 patients with depression and qi stagnation admitted to the First Affiliated Hospital of Hunan University of Traditional Chinese Medicine from June 2022 to July 2023 were selected as the research subjects.They were divided into a study group (45 cases) and a control group (45 cases) according to a random number table method.The control group took Fluoxetine Hydrochloride Capsules,and the study group was treated with Chaihu Shugan Powder combined with Yueju Pills on top of that.Both groups were treated for 8 weeks.The clinical efficacy,traditional Chinese medicine syndrome score,depression improvement score,and adverse reactions were compared between the two groups.Results The total effective rate of the study group was 93.33%,which was higher than that of the control group(75.56%),and the difference was statistically significant(P＜0.05).The traditional Chinese medicine syndrome score,Hamilton Depression Rating Scale,and self-rating depression scale scores in the study group were lower than those in the control group,and the difference was statistically significant (P＜0.05).The total incidence of adverse reactions in the study group was lower than that in the control group,and the difference was statistically significant (P＜0.05).Conclusion The application of Chaihu Shugan Powder combined with Yueju Pills in the treatment of depression and qi stagnation can achieve significant effects,effectively alleviate various clinical symptoms in patients,reduce scores on various depression scales,improve depression conditions,and have fewer adverse reactions and higher safety,which is worthy of promotion and application. 2024 Vol. 31 (17): 104-107 [Abstract] ( 8 ) HTML (1 KB)  PDF (565 KB)  ( 1 ) 108 Characteristics of nosocomial infection in the First Affiliated Hospital of Nanchang University from 2019 to 2021 CHENG Tao1 FU Wenshan2 KANG Xiuhua2 LIU Minyu2 ZHOU Yun2 XIANG Tianxin2 ZHU Chunmei2 Objective The characteristics of nosocomial infection in the First Affiliated Hospital of Nanchang University were analyzed to provide the basis for further promoting nosocomial infection prevention and control.Methods The information of all inpatients in the First Affiliated Hospital of Nanchang University from 2019 to 2021 was retrospectively analyzed,and the incidence of nosocomial infection was compared.Results The incidences of nosocomial infection in 2020 and 2021 were lower than that in 2019,the differences were statistically significant(P＜0.017).Nosocomial infection sites were mainly concentrated in respiratory tract and blood.Except for gastrointestinal tract sites,the incidences of infection in 2020 and 2021 were lower than that in 2019,and the differences were statistically significant(P＜0.017).The pathogens of nosocomial infections from 2019 to 2021 were mainly Acinetobacter baumannii and Klebsiella pneumoniae.Conclusion Related health measures such as wearing masks,strengthening disinfection and hand hygiene can reduce the risk of nosocomial infection to a certain extent.Hospitals should timely adjust and improve nosocomial infection prevention and control strategies and measures according to the actual characteristics and trends of nosocomial infection. 2024 Vol. 31 (17): 108-111 [Abstract] ( 7 ) HTML (1 KB)  PDF (517 KB)  ( 11 ) 112 Influencing factors of alpha-fetoprotein level in patients with primary hepatic carcinoma in Yanbian area LI Sa YU Xing ZANG Longzheng Objective To investigate the influencing factors of alpha-fetoprotein(AFP)level in patients with primary hepatic carcinoma(PHC)in Yanbian area.Methods The clinical data of 480 patients with PHC in Yanbian Hospital from 2016 to 2022 was retrospectively analyzed.Clinical data included general condition,alcohol consumption,serum protein level,liver cirrhosis,portal vein cancer thrombus,tumor size and number,hepatitis B virus (HBV)infection and AFP level.Univariate and logistic regression analysis were used to analyze the influencing factors of AFP in PHC patients.Results The results of single factor analysis showed that the level of AFP in patients with PHC was related to gender,nationality,cirrhosis,portal vein cancer thrombus,tumor number and HBV markers,with statistical significances(P＜0.05).The level of AFP in patients with PHC was not related to age,four liver function indexes,tumor size and alcohol consumption,the differences were not significant(P＞0.05).Logistic regression analysis showed that portal vein cancer thrombus(β=1.837,OR=6.280,95%CI=3.061-12.883),HBV marker positive(β=2.049,OR=0.341,95%CI=3.976-15.160),multiple tumor(β=0.541,OR=1.717,95%CI=1.087-2.713)were independent risk factors for AFP levels(P＜0.05).Conclusion AFP levels in patients with PHC were correlated with gender,ethnicity,cirrhosis,portal vein cancer thrombus,tumor number and HBV marker infection.Positive portal vein cancer thrombus,HBV marker positive and multiple tumor were independent risk factors for PHC. 2024 Vol. 31 (17): 112-115 [Abstract] ( 9 ) HTML (1 KB)  PDF (481 KB)  ( 2 ) 116 Relevance of knowledge sharing,interpersonal communication,organizational trust and empowering leadership among intensive care unit nurses LI Ying1 SHI Xiaopu2 HONG Hui3 MU Junrui4 Objective To explore the correlation between knowledge sharing,interpersonal communication,organizational trust and empowering leadership among nurses in intensive care unit(ICU).Methods A total of 206 ICU nurses from 8 Grade A hospitals in Shandong Province and Jilin Province from July to October 2022 were selected as the study subjects.General data questionnaire,nurse knowledge sharing,empowerment leadership,communication ability and organizational trust scale were used to analyze the study.Results Knowledge sharing among nurses was (3.87±0.59)points,empowering leadership was(3.71±0.52)points,communication ability was(3.71±0.55)points,organizational trust was(3.69±0.62)points.Empowered leadership,communication ability,organizational trust and knowledge sharing were all positively correlated (P＜0.05).The direct effect of empowered leadership on knowledge sharing was 0.548,the indirect effect was 0.098,and the total effect was 0.647.The direct effect of communication ability on knowledge sharing behavior of nurses was 0.161,the indirect effect was 0.084,and the total effect was 0.245.Conclusion In order to improve the knowledge sharing behavior of nurses,it is necessary not only to improve the empowerment level of nursing managers and the communication ability of nurses,but also to explore ways to improve the trust of nurses in the human resource management scheme of nursing organizations. 2024 Vol. 31 (17): 116-120 [Abstract] ( 8 ) HTML (1 KB)  PDF  (0 KB)  ( 12 ) 121 Problems in the implementation and operation of prescription pre-audit system and optimization practice effect in Yunfu People′s Hospital CHEN Yanping ZHANG Ruihui ZHANG Qingshang CHENG Mingjian Objective To optimize the rules of the prescription pre-audit system of Yunfu People's Hospital,and to evaluate its clinical practice effect.Methods From July 2022 to April 2023,Yunfu People's Hospital established an audit team to screen the defects in the pre-audit system,and gradually completed the optimization.Prescriptions issued in outpatient clinics before optimization (February to June 2022)and after optimization (May to September 2023)were summarized and analyzed.Prescriptions before optimization were set as control group,prescriptions after optimization were set as observation group.The prescription intervention rate,intervention success rate and unreasonable prescription number of the two groups were compared.Results The total number of prescriptions in the control group was 265 095,the number of prescriptions reviewed by the audit system was 88 806,and the number of successful prescriptions reviewed was 9 987.The total number of outpatient prescriptions in the observation group was 303 765,the number of prescriptions reviewed by the audit system was 53 760,and the number of successful prescriptions reviewed was 11 980.The prescription intervention rate of observation group(17.70%)was lower than that of control group(33.50%),and the intervention success rate(22.28%) was higher than that of control group (11.25%),the differences were statistically significant (P＜0.05).The same number of prescriptions were extracted from the two groups,and the irrational prescription ratio in the observation group(0.55%)was lower than that in the control group(1.87%),the difference was statistically significant(P＜0.05).Conclusion After the optimization of the pre-audit system in Yunfu People's Hospital,the intervention rate of prescription was reduced,the success rate of intervention was increased,the invalid warning was reduced,the unreasonable prescription quantity was reduced,and the prescription quality was effectively improved. 2024 Vol. 31 (17): 121-124转129 [Abstract] ( 8 ) HTML (1 KB)  PDF  (0 KB)  ( 6 ) 125 Research on the calculation of medical technology cooperation fees in public hospitals SUN Qianying1 LI Qiuping2 WANG Meng3 LI Yanyan1 GUAN Boyuan1 SUN Jing1 ZHANG Lin3 Implementing medical technology cooperation work in public hospitals is essential for the hospital's external development.In the process of medical technology cooperation,the calculation of cooperation fees is an important aspect of the hospital's refined management.However,the calculation of cooperation fees is a difficult point in the management of medical technology cooperation.From the perspective of the technology-exporting hospital,this study describes the principles and methods of medical technology cooperation fee collection,clarifies the composition of medical technology cooperation fees by applying the full-cost accounting method,and provides accounting methods.The study results show that the collection of medical technology cooperation fees should follow the basic principles of public welfare first,mutual benefit,and risk control.There are two main forms of medical technology cooperation fees:proportional fees and fixed fees.The medical technology cooperation fees are primarily composed of the medical technology cooperation revenue,the labor cost of dispatched staff,the cost of training for the receiving staff,the hospital's brand usage fee,the replacement cost of dispatched staff,and/or the opportunity cost of dispatched staff.In the specific accounting process,the labor cost,replacement cost,and medical opportunity cost of dispatched staff can be determined by aggregating and allocating costs.Educational,research,and prevention opportunity costs of the dispatched staff can be given a coefficient based on the the opportunity cost of medical opportunity costs.The training fee is charged separately.The hospital brand usage fees and medical technology cooperation revenue should be negotiated and determined by both parties based on the principle of mutual benefit.This study analyzes and discusses the composition and accounting methods of medical technology cooperation fees to provide some reference managing medical technology cooperation. 2024 Vol. 31 (17): 125-129 [Abstract] ( 6 ) HTML (1 KB)  PDF  (0 KB)  ( 6 ) 130 Application effect of process reengineering for special needs specialists in the First Affiliated Hospital of Dalian medical university SUN Xiaojun WANG Xinyang▲ Objective To study the application effect of process reengineering in the outpatient department of special needs specialists in the First Affiliated Hospital of Dalian Medical University.Methods Through the observation and problem analysis of the overall process of outpatient treatment for special needs experts in the First Affiliated Hospital of Dalian Medical University,this study found the bottleneck restricting the further improvement of the efficiency of outpatient treatment for special needs experts,and sorted out the problems in the whole process from appointment to return visit from the three links before,during and after consultation,and proposed optimization and reconstruction on the basis of the existing process.The application effect after reengineering was compared with that before reengineering in terms of process,time cost and number source utilization.Results After the implementation of fine management and process reengineering，the efficiency，informatization level and service quality of the special needs experts outpatient department in the First Affiliated Hospital of Dalian Medical University were significantly improved，the invalid waiting time of patients in each link was significantly shortened，and the number source utilization rate was increased from 59.9%to 90.5%.Conclusion It is of practical significance to improve the patient experience,improve the quality of medical care,promote the harmonious relationship between doctors and patients,and improve the comprehensive competitiveness of hospitals through the implementation of process reengineering in the outpatient department of special needs experts. 2024 Vol. 31 (17): 130-134 [Abstract] ( 7 ) HTML (1 KB)  PDF  (0 KB)  ( 14 ) 135 Application effect of step teaching in sub-specialty operation coordination in cardiothoracic surgery WAN Qian LIU Luhua▲ Objective To explore the application effect of step teaching in sub-specialty operation coordination in cardiothoracic surgery.Methods A total of 40 nurses in the Operation Room of the First Hospital of Nanchang from January 2022 to December were selected as the study objects,and they were divided into experimental group (20 cases)and control group(20 cases)according to random number table method.Both groups were taught operating techniques according to the guide.The experimental group was trained in the sub-specialty of cardiothoracic surgery with step teaching,while the control group was trained with traditional teaching methods.After the training of the two groups,the theoretical assessment,situational simulation teaching exercise and practical operation assessment (accuracy,instrument and equipment assembly time,and surgical instrument maintenance accuracy) were carried out.The assessment scores of two groups were compared.The Chinese Jeffries simulation teaching design Scale was used to evaluate the training effect.Results The test scores of theoretical knowledge in experimental group were higher than those in control group,and the differences were statistically significant (P＜0.05).The test scores of simulated teaching practice in experimental group were higher than those in control group,and the differences were statistically significant (P＜0.05).The score of teaching evaluation effect in experimental group was higher than that in control group,the difference was statistically significant (P＜0.05).The scores of study card assessment in the experimental group were higher than those of the control group,and time of study card assessment in the experimental group was shorter than that of the control group,and the differences were statistically significant (P＜0.05).Conclusion The use of step training mode can effectively improve the scores of theoretical knowledge and practical operation assessment in the training of professional nurses in thoracic surgery,and the step training mode can improve the self-learning ability of sub-professional nurses,the accuracy of actual operation,the assembly time of instruments and equipment,the cleaning and maintenance of instruments.It can improve the teaching quality of the sub-professional nursing of the operating room cardiothoracic surgery. 2024 Vol. 31 (17): 135-140 [Abstract] ( 7 ) HTML (1 KB)  PDF  (0 KB)  ( 15 ) 141 Application of problem-based learning teaching method based on scenario simulation in the teaching of acute chest pain YE Ning LIU Shijie PANG Chengkai KANG Yumiao YU Wenjun ZHENG Hong Objective To explore the application effect of scenario simulation combined with problem-based learning(PBL)teaching method in clinical medicine undergraduate teaching.Methods A total of 288 medical students of grade 2020 majoring in Clinical medicine in Guilin Medical University who had the course of ＂acute chest pain＂ in emergency medicine from March to September 2023 were selected as the study subjects.Two classes were randomly selected as the observation group(145 students)and the other two classes as the control group(143 students).The control group adopted the traditional teaching method.The observation group adopted scenario simulation combined with PBL teaching method.After the course,the teaching effect of the two different teaching methods was compared by means of questionnaire survey and examination.Results The scores of differential diagnosis and treatment method and quiz assessment total score after class in observation group were higher than those in control group,and the differences were statistically significant (P＜0.05).The scores of learning interest,knowledge understanding,emergency thinking and differential judgment in observation group were higher than those in control group,and the differences were statistically significant(P＜0.05).There was no significant difference in the scores of emergency ability between the two groups (P＞0.05).In terms of teaching evaluation,the highest score was learning interest (9.57±0.68)points,followed by emergency thinking (9.50±0.69)points.Conclusion The PBL teaching method based on scenario simulation has good application effect in the course of＂acute chest pain＂in emergency medicine,which can improve the enthusiasm and initiative of medical students and help to cultivate clinical thinking in emergency.It can be popularized and applied in emergency undergraduate teaching course. 2024 Vol. 31 (17): 141-144 [Abstract] ( 6 ) HTML (1 KB)  PDF  (0 KB)  ( 22 ) 145 Application of emergency bedside ultrasound teaching in resident training courses WANG Shujuan LI Maoyi HUANG Hongshan GAN Li LI Caiqiang DENG Zuqun HUANG Meipiao Objective To analyze the influence of bedside ultrasound teaching on clinical comprehensive ability of residents in emergency department.Methods A total of sixty newly admitted residents in Baise People's Hospital from January 2021 to June 2023 were selected as the study objects,and were divided into control group(n=30)and observation group(n=30)by random number table method.All new physicians who enter the ultrasound department are trained and guided by senior physicians for 2 weeks,8 hours per day.The control group followed their supervisor throughout the day for training in the consultation room.The observation group received training in the consultation room in the morning and followed their supervisor to participate in emergency bedside ultrasound examination in the afternoon.The results of theoretical assessment,operational skills assessment,clinical thinking ability score and teaching satisfaction were compared between the two groups of doctors after training.Results There were no significant differences in the theoretical examination scores between the two groups after training(P＞0.05).The observation group had higher scores in the operational skill assessment,clinical thinking ability score,independent learning ability and teaching satisfaction than the control group,and the differences were statistically significant (P＜0.05).Conclusion Integrating emergency bedside ultrasound teaching into consultation room training can significantly improve resident physicians' operational skills,independent learning ability and clinical thinking,and is worth promoting. 2024 Vol. 31 (17): 145-148转152 [Abstract] ( 7 ) HTML (1 KB)  PDF  (0 KB)  ( 8 ) 149 Application effect of standardized nursing in the treatment of pediatric patients with venous indwelling needle puncture and negative pressure drainage WU Pingping TANG Le▲ CHEN Pei LIU Wenwen Objective To explore the application effect of standardized nursing in the treatment of pediatric patients with venous indwelling needle puncture and negative pressure drainage.Methods A total of 50 pediatric patients with scalp hematoma admitted to the Department of Pediatric Surgery,Jiujiang Maternal and Child Health Hospital from January 2018 to August 2023 were selected as the study objects retrospectively.They were divided into observation group (25 cases)and control group(25 cases)according to different nursing methods.The observation group was treated with standardized nursing procedures,while the control group was treated with routine nursing.The quality of care,time for scalp hematoma disappearance,hospital stay,and hospital expenses were compared between the two groups.Results The nursing quality score of the observation group was higher nursing quality score than that of the control group,and the difference was statistically significant(P＜0.05).The disappearance time of scalp hematoma and hospitalization time of the observation group was shorter than that of the control group,the hospitalization expenses of the observation group were less than those of the control group,and the differences were statistically significant (P＜0.05).Conclusion Providing standardized nursing procedures while using intravenous indwelling needle puncture and negative pressure drainage to treat pediatric scalp hematoma can effectively reduce the occurrence of complications and improve treatment effectiveness,which is worthy of research and promotion. 2024 Vol. 31 (17): 149-152 [Abstract] ( 6 ) HTML (1 KB)  PDF  (0 KB)  ( 6 ) 153 Application of psychological flexibility intervention based on WeChat platform in the nursing of gynecological malignant tumor patients ZENG Jinlan1 XIONG Ting2 WAN Xing3 FU Zhou4 DU Caizhen4 Objective To observe the application effect of psychological flexibility intervention based on WeChat platform in the nursing of gynecological malignant tumor patients.Methods A total of 80 patients with gynecological malignant tumor admitted to Fengcheng People's Hospital from March 2021 to September 2022 were selected as the study subjects.They werw divided into control group and observation group by random number table method with 40 cases.The control group received routine psychological intervention,and the observation group received psychological resilience intervention based on WeChat platform.The psychological flexibility (connor-Davidson resilience scale [CD-RISC]),anxiety and depression(self-rating anxiety scale[SAS],self-rating depression scale[SDS]),cancer fatigue degree(multidimensional fatigue symptom inventory-short form [MFSI-SF])and satisfaction of the two groups were compared.Results After one month intervention,the CD-RISC score of two groups was higher than before intervention,and the observation group was higher than the control group,the differences were statistically significant (P＜0.05).After one month intervention,the scores of SAS,SDS and MFSI-SF in two groups were lower than before intervention,and the observation group was lower than the control group,the differences were statistically significant (P＜0.05).The nursing satisfaction score of the observation group was higher than that of the control group,the difference was statistically significant(P＜0.05).Conclusion Psychological flexibility intervention based on WeChat platform for gynecological malignant tumor patients can improve psychological flexibility,relieve anxiety and depression,reduce cancer-related fatigue and improve satisfaction. 2024 Vol. 31 (17): 153-156 [Abstract] ( 6 ) HTML (1 KB)  PDF  (0 KB)  ( 3 ) 157 Effect of intervention based on social network intervention on dependence level of stroke patients in recovery period YANG Yan1 YANG Peng2▲ Objective To explore the clinical nursing effect of social network intervention on dependency level of stroke patients in recovery period.Methods A total of 80 stroke patients in recovery period admitted to the Guangzhou Haizhu District Hospital of Traditional Chinese Medicine from January to December 2022 were selected as the study objects.According to random number table method,they were divided into control group(40 cases)and intervention group(40 cases).Traditional rehabilitation nursing mode was implemented in the control group,and social network intervention was implemented in the intervention group based on the control group.The care dependency scale (CDS)score,Lubben social network scale(LSNS)score,recurrence frequency,complication rate,length of hospital stay and cost were compared between the two groups.Results There were no significant differences in CDS score and Lubben score between the intervention group and the control group at admission (P＞0.05).After 90 days of intervention,the CDS and Lubben scores of two groups were higher than those at admission,and the intervention group was higher than the control group,the differences were statistically significant(P＜0.05).The total incidence of complications and the number of recurrent stroke in the intervention group was lower than that in the control group,the length of hospitalization was shorter than that in the control group,and the hospitalization cost was lower than that in the control group,the differences were statistically significant (P＜0.05).Conclusion The use of the Internet in rehabilitation nursing intervention for stroke convalescent patients can reduce the degree of dependence on others'care,reduce the recurrence rate and complication rate,and improve the quality of life of patients. 2024 Vol. 31 (17): 157-160 [Abstract] ( 8 ) HTML (1 KB)  PDF  (0 KB)  ( 1 ) 161 Impact of case management nursing combined with airway clearance technology on patients with chronic obstructive pulmonary disease CHI Haiyan LIN Yiting WU Xuejuan Objective To explore the impact of case management nursing combined with airway clearance technology on patients with chronic obstructive pulmonary disease.Methods A total of 68 patients admitted to the Department of Respiratory and Critical Care Medicine,Xiamen Haicang Hospital from January 2021 to June 2023 were selected as the study objects,and they were divided into control group (34 cases)and experimental group (34 cases)according to random number table method.The control group received routine nursing interventions,while the experimental group received case management nursing combined with airway clearance technology intervention on the basis of the control group.The sputum score,dyspnea scale score,sputum viscosity,forced vital capacity(FVC),first second forced expiratory volume(FEV1),FEV1/FVC,arterial oxygen pressure(PaO2),arterial carbon dioxide pressure(PCO2),satisfaction,and compliance of the two groups were compared.Results The sputum score,dyspnea scale score,sputum viscosity,and PCO2 of the experimental group patients were lower than those of the control group,and the differences were statistically significant(P＜0.05).The PaO2,FVC,FEV1,FEV1/FVC,total satisfaction,and total compliance of the experimental group patients were higher than those of the control group,and the differences were statistically significant (P＜0.05).Conclusion Case management nursing combined with airway clearance technology intervention can reduce patients' dyspnea score and sputum score,which is beneficial for improving lung function and blood gas index levels,thereby reducing the incidence of complications and ultimately improving overall treatment satisfaction. 2024 Vol. 31 (17): 161-165 [Abstract] ( 8 ) HTML (1 KB)  PDF  (0 KB)  ( 1 ) 166 Application of phased nursing intervention in CT-guided 3D retro-radiotherapy in patients with primary treatment for locally advanced cervical cancer HUA Shuiying YU Jing HE Hua▲ Objective To evaluate the effect of phased nursing intervention in CT-guided 3D retro-radiotherapy in patients with primary treatment for locally advanced cervical cancer.Methods A total of 68 patients with locally advanced cervical cancer admitted to Jiujiang Third People's Tumor Hospital from July 2020 to June 2021 were selected as the research objects.According to the different hospitalization time,they were divided into the study group(July to December 2020)and the control group (January to June 2021),with 34 cases in each group.Two groups of patients were treated with four-field box radiation and 3D retro-radiotherapy,the control group was treated with routine nursing intervention,and the study group was treated with phased nursing intervention.The self-rating anxiety scale(SAS),self-rating depression scale(SDS),visual analog scale (VAS),piper fatigue scale-revised (PFS-R)and nursing satisfaction were compared between the two groups.Results The scores of SAS,SDS,VAS and PFS-R after nursing in the two groups were lower than before nursing in the same group,the scores of SAS,SDS,VAS and PFS-R in the study group were lower than those in the control group,and the nursing satisfaction in the study group was higher than that in the control group,the differences were statistically significant (P＜0.05).Conclusion In the clinical treatment of patients with early locally advanced cervical cancer,nursing intervention is a necessary step,especially in the receiving of CT-guided 3D retro-radiotherapy Phased nursing intervention can alleviate patients'mental stress,alleviate patients'pain and cancer fatigue,and improve patients'nursing satisfaction. 2024 Vol. 31 (17): 166-171 [Abstract] ( 8 ) HTML (1 KB)  PDF  (0 KB)  ( 24 ) 172 Research progress on metabolic syndrome in patients with schizophrenia LIU Yunfei1 LIU Congcong2 Schizophrenia is a serious mental illness that accounts for the largest number of mental illnesses with significantly increased mortality worldwide.Numerous studies have shown that people with schizophrenia have certain metabolic abnormalities,confirming that metabolic syndrome is more common in people with schizophrenia than in the general population,and studies have shown that people with schizophrenia die on average 25 years earlier than the general population.Much of this risk is due to chronic diseases,with a particularly high incidence and prevalence of coronary heart disease,which can lead to the loss of life in severe cases.There are also studies that suggest that people with schizophrenia may be more susceptible to metabolic syndrome,regardless of whether they take psychiatric drugs.There are also studies that show that a significant proportion of patients with schizophrenia develop metabolic syndrome first,although more research is needed to confirm this.At present,the metabolic field of this disease is the focus of many researchers,and the early and late appearance of metabolic syndrome and schizophrenia and whether there is a correlation need further research. 2024 Vol. 31 (17): 172-175 [Abstract] ( 6 ) HTML (1 KB)  PDF  (0 KB)  ( 10 ) 176 Research progress in the diagnosis and treatment of immune checkpoint inhibitors related myocarditis LIAO Chunyao1 WU Lidong1▲ LIAO Mengyan2 With the widespread development of oncology and immunology in clinical practice,its application in the treatment of malignant tumor patients has become the most advanced treatment method in the field of anti-tumor therapy.As a new type of anti-tumor drug,immune checkpoint inhibitors(ICIs)are an important method for implementing immunotherapy in cancer patients and have been widely used in the treatment of malignant tumor patients.The use of ICIs is particularly important for improving the prognosis of advanced malignant tumor patients,bringing breakthrough progress to the treatment of malignant tumor patients,and can greatly prolong their survival time and improve their quality of life.However,the treatment of ICIs inevitably brings about immune related adverse reactions,among which ICIs related myocarditis has a higher risk of occurrence.Currently,there is no clear definition of the pathogenesis and etiology of ICIs related myocarditis in clinical practice,which may be closely related to factors such as T cell activation,immune testing,and the production of autoantibodies.If patients are not diagnosed and treated in a timely manner during this process,it can pose a serious threat to their life safety.Therefore,this article reviews the definition and pathogenesis of ICIs related myocarditis,clinical diagnosis of ICIs related myocarditis,and clinical treatment of ICIs related myocarditis,providing effective reference for clinical treatment of ICIs related myocarditis. 2024 Vol. 31 (17): 176-179 [Abstract] ( 6 ) HTML (1 KB)  PDF  (0 KB)  ( 3 ) 180 Research progress of thermal ablation therapy for metastatic lung cancer WANG Houze DU Ming Lung is one of the most common metastatic sites of malignant tumors.In recent years,percutaneous tumor ablation has attracted more and more attention due to its minimally invasive approach,and it has become a new treatment for metastatic lung cancer patients who have lost the opportunity of surgery.Radiofrequency ablation,microwave ablation and cryoablation are three widely used thermal ablation methods in the lung.Among them,radiofrequency ablation and microwave ablation induce molecular collision and friction in tumor tissues through the application of alternating high-frequency current or electromagnetic field oscillation,generating heat to achieve coagulation necrosis of tumor cells.Several studies have reported the safety and efficacy of these two ablation methods for metastatic lung cancer,but there is still a lack of randomized controlled trials to provide more evidence-based medical evidence for the use of this technology.Cryoablation of target lesions at low temperature leads to protein denaturation,cell membrane rupture,and microvascular thrombosis,thereby inducing cell death and tissue injury.Cryoablation is currently a hot topic in the field of ablation therapy,and it has performed well in the latest prospective studies.However,the existing survival data are limited,especially the long-term follow-up data are still lacking.Each of the three ablation methods for metastatic lung cancer has its advantages and disadvantages.The specific selection of ablation methods needs to be evaluated by multiple disciplines according to the patient's condition and the actual situation of each center,and an individualized treatment plan should be formulated.In view of the increasing clinical demand,this paper reviews the current research progress of thermal ablation therapy for metastatic lung cancer,with a view to assisting clinical decision-making. 2024 Vol. 31 (17): 180-184 [Abstract] ( 6 ) HTML (1 KB)  PDF  (0 KB)  ( 19 ) 185 Application and research progress of microneedle in dermatology LI Yanhong1 LI Zhenjie2 Microneedling is an emerging therapeutic method in recent years.In recent years,its clinical application has been gradually promoted and popularized,especially in dermatology.Microneedles have been widely used in pigmentary skin diseases,alopecia,acne,scars,facial rejuvenation and other fields,with a very broad application prospect.Microneedling can form a large number of small micro-channels on the surface of the skin,so that the drug can easily penetrate the stratum corneum of the skin,thereby increasing the transdermal absorption of the drug and making the drug play a better effect.Microneedle combined with Tacrolimus in the treatment of vitiligo,enhance curative effect,speed up the curative effect in time;Microneedle combined with Minoxidil can improve the curative effect of various alopecia diseases.Compared with laser and autologous platelet rich plasma(PRP),microneedle is easier to carry out and cheaper to treat scars.Microneedles can also be used in the treatment of herpes zoster neuralgia,neurodermatitis,eczema,rosacea,hormone-dependent dermatitis and other skin diseases.In particular,the development of soluble microneedles provides a new safe and effective way for microneedles to treat diseases. 2024 Vol. 31 (17): 185-188 [Abstract] ( 5 ) HTML (1 KB)  PDF  (0 KB)  ( 31 ) 189 Research progress of Omaveloxolone in treatment of Friedreich′s ataxia BIAN Tingting1 HE Xin2 Omaveloxolone was officially approved by the U.S.Food and Drug Administration (FDA)in February 2023 for the treatment of Friedreich's ataxia (FRDA)in adults and adolescents 16 years and older.Omaveloxolone has received“orphan drug”,fast track and rare pediatric disease designation from the FDA,as well as“orphan drug”designation from the European Commission.FRDA is an extremely rare neuromuscular disorder that is an inherited disorder caused by mutations in the frataxin(FXN)gene that encodes the protein ataxin.Nuclear factor E2 associated factor 2(Nrf2)signaling is inhibited in FRDA patients,and Omaveloxolone inhibits Nrf2 ubiquitination by inhibiting Kelch-like ECH associated protein 1(KEAP1),thereby activating Nrf2.By activating Nrf2,it can repair mitochondrial function,reduce oxidative stress and inhibit pro-inflammatory signal.Therefore,Omaveloxolone improves neurological function and slows disease progression in patients with FRDA.The mechanism of action,pharmacodynamics,pharmacokinetics,clinical studies and safety were reviewed. 2024 Vol. 31 (17): 189-192 [Abstract] ( 6 ) HTML (1 KB)  PDF  (0 KB)  ( 3 ) 193 Progress in modern research on Gloriosa superba L. LAN Jiaqin1 GONG Yunqi2 LIU Yidan2 LIU Junfeng2 Gloriosa superba L.belongs to the genus of Liliaceae.A large number of academic studies have reported that there are mainly seven alkaloids in the roots and tubers of Gloriosa superba L.,such as colchicine,β-lumi(-)-colchicine,r-colchicine,1,2-dimethylcolchicine,2，3-demethylcolchicine,3-demethylcolchicine and so on.In addition,it has been reported that the whole plant of Gloriosa superba L.also contains glycosides,flavonoids,steroids,terpenoids,saponins,steroids,phenols and resins.A number of modern pharmacological studies have pointed out that Gloriosa superba L.extract has a variety of anticancer effects,such as anti-gout,antibacterial,anti-pancreatic cancer,anti-colon cancer,a nti-oral cancer,anti-cervical cancer,anti-liver cancer,anti-lung cancer,anti-breast cancer and so on.Gloriosa superba L.also has a variety of pharmacological activities,such as anti-dandruff disease,anti-inflammatory and analgesic,anti-oxidation,anti-ulcer and so on,but most of them are not clear about their mechanism and need to be further studied.As Gloriosa superba L.has gradually become the main source of colchicine in modern research,the determination method of colchicine in Gloriosa superba L.has also become an important aspect of the research and utilization of Gloriosa superba L..The main methods are high performance thin layer chromatography (HPTLC),liquid phase high resolution high precision mass spectrometry (LC-HRMS),high performance liquid chromatography (HPLC).The author summarizes the related studies of Gloriosa superba L.from the aspects of chemical composition,pharmacological action,quality research and so on,in order to provide a scientific theoretical basis for the further development and utilization of Gloriosa superba L.. 2024 Vol. 31 (17): 193-198 [Abstract] ( 8 ) HTML (1 KB)  PDF  (0 KB)  ( 5 )

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