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| Bioinformatic research on pathogenesis of idiopathic pulmonary fibrosis |
| WEI Shuhong |
| Department of Internal Medicine,the Second People's Hospital of Jinan,Shandong Province,Jinan 250021,China |
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Abstract Objective To explore the differential expression genes,the core genes and potential mechanisms associated with the pathogenesis of idiopathic pulmonary fibrosis (IPF)based on bioinformatics.Methods The GSE10667,GSE31934 and GSE24206 datasets were downloaded from the Gene Expression Omnibus database of the National Center for Biotechnology Information.The DEGs of IPF were screened,the protein-protein interaction network was constructed,the enrichment analysis and functional cluster analysis were performed in order to screen the core genes,signaling pathways and related microRNAs.Results After screening,a total of 107 DGEs in IPF were obtained,CXCL12,ACAN,IGF1,CXCL8,CSF2,ICAM1 were the core genes of IPF which enriched in signaling pathways such as transforming growth factor-β,nuclear transcription factor-κB,tumor necrosis factor,interleukin-17,Janus kinase/signal transducer and activator of transcription,phosphatidylinositol-3-kinases/protein-serine-threonine kinase.The miR-4465,miR-182-5p,miR-1297,miR-1252-3p and other microRNAs which were closely related to IPF were obtained by functional cluster analysis.Conclusion There are significant differences in gene expression during the pathogenesis of IPF.The pathological process involves multiple targets and pathways.IPF pathogenesis may be regulated by multiple microRNAs.CXCL12,ACAN,IGF1,CXCL8,CSF2,ICAM1 may be the core genes in the pathogenesis of IPF.
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