Objective To explore the clinical effect of Pantoprazole combined with Qizhi Weitong Granules combined with lifestyle regulation in the treatment of elderly patients with gastroesophageal reflux disease.Methods A retrospective study was conducted between September 2019 to September 2021, a total of 140 elderly patients with GERD who were treated in Peking University Hospital were recruited, according to the drug treatment regimen is divided into observation group (70 cases) and control group (70 cases). The observation group was treated with Pantoprazole combined with Qizhi Weitong Granules combined with lifestyle regulation for comprehensive treatment, while the control group was treated with Pantoprazole combined with lifestyle regulation for comprehensive treatment. The clinical effects of the two groups were evaluated from the two evaluation systems of traditional Chinese medicine and Western medicine, and the improvement of symptoms, traditional Chinese medicine syndrome efficacy, quality of life and adverse reactions of the two groups were compared. Result After treatment, the reflux disease questionnaire scores and gastroesophageal reflux disease health-related quality of life scale scores of the observation group were lower than those of the control group, and the differences were statistically significant (P＜0.05). The total effective rate of syndrome treatment was higher than that of the control group, and the difference was statistically significant (P＜0.05). After treatment, the total incidence of adverse reactions in the observation group was lower than that in the control group, and the difference was statistically significant (P＜0.05). Conclusion After effective regulation of lifestyle, the combined treatment of Pantoprazole and Qizhi Weitong Granules in elderly patients with gastroesophageal reflux disease can improve therapeutic effect, curative effects on gastroesophageal reflux disease symptoms, health-related quality of life and reduce incidence of adverse effects. The treatment was worthy of clinical application.

 

Objective To investigate the effect of Yiqi Fumai Injection combined with Norepinephrine in the treatment of patients with pyemia and its effect on the cardiac function, inflammatory indicators and prognosis. Methods A total of 100 patients with pyemia who were admitted to Yunfu Hospital of Traditional Chinese Medicine, the Second Affiliated Hospital of Guangdong Pharmaceutical University from January 2019 to June 2021 were selected as the research subjects, and they were divided into the observation group (n=50) and the control group (n=50) by the random number table method. The control group was treated with Norepinephrine, and the observation group was treated with Yiqi Fumai Injection combined with Norepinephrine. The cardiac troponin I (cTnI), N-terminal brain natriuretic peptide precursor (NT-proBNP), left ventricular ejection fraction (LVEF), stroke volume (SV), C-reactive protein (CRP), interleukin 6 (IL-6), interleukin 8 (IL-8), procalcitonin (PCT), tumor necrosis factor-α (TNF-α), acute physiology and chronic health evaluation scoring system (APACHEⅡ) and sepsis-related organ failure assessment (SOFA) in the two groups were recorded and observed before and after 7 days of treatment. Results A total of 48 patients in the observation group and 45 in the control group completed the study. There were no significant differences in the levels of cTnI,NT-proBNP, LVEF, SV, CRP, IL-6, IL-8, PCT, APACHEⅡand SOFA between the two groups before treatment (P＞0.05). After 7 days of treatment, the levels of cTnI, CRP, IL-6, IL-8, PCT, APACHEⅡand SOFA in the two groups were lower than those before treatment, while the levels of LVEF and SV were higher than those before treatment, the differences were statistically significant (P＜0.05). The levels of cTnI, NT-proBNP, CRP, IL-6, IL-8, PCT, APACHEⅡand SOFA in the observation group after 7 days of treatment were lower than those in the control group, while the levels of LVEF and SV in the observation group after 7 days of treatment were higher than those in the control group, and the differences were statistically significant (P＜0.05). Conclusion The administration of Yiqi Fumai Injection combined with Norepinephrine in patients with pyemia can stabilize cardiac function, reduce the level of inflammatory indicators in vivo, improve the condition and improve the prognosis

 

Skeletal muscle, which accounts for about 40% of adult body weight, plays an important role in regulating the basic life activities like respiration and movement of the human body. At present, due to the volumetric muscle loss of skeletal muscle caused by severe trauma, the repair ability of skeletal muscle will be severely damaged, which can lead to muscle dysfunction or loss of function. And the clinical treatment of autologous tissue transplantation also has the problems of high cost, great risk and unstable treatment outcomes. In the biomedical field, a variety of natural and synthetic materials have been developed for skeletal muscle regeneration. As a kind of polymer network system with water as dispersion medium, hydrogel has the characteristics of good biocompatibility and can imitate the natural extracellular matrix. Hydrogel is widely used in cell and growth factors delivery of muscle tissue engineering at present.In this paper, the classification and preparation of hydrogels and their applications in skeletal muscle tissue regeneration are reviewed, and the research status of hydrogel materials from different sources in skeletal muscle regeneration was mainly discussed, which is hoping to provide some reference for the design and application of skeletal muscle regeneration materials.

 

Objective To explore the clinical effect of Xuebijing Injection on severe acute pancreatitis and its regulating effect on the level of inflammatory factors. Methods A total of 60 patients with severe pancreatitis admitted to our hospital from July 2019 to September 2020 were selected as the research objects, and they were divided into the control group (30 cases) and the experimental group (30 cases) using the parity number assignment method. The control group was treated with conventional treatment, and the experimental group was treated with conventional treatment combined with Xuebijing treatment plan. Time of hospitalization, inflammatory factor levels, incidence of adverse reactions, and mortality were compared between the two groups. Results Before treatment, there was no significant difference in the levels of interleukin-6 (IL-6), serum C-reactive protein (hs-CRP), and tumor necrosis factor-α (TNF-α) between the two groups of patients (P＞0.05). After treatment, the IL-6, hs-CRP and TNF-α in the experimental group were lower than those in the control group, and the differences were statistically significant (P＜0.05). The maintenance time of mechanical ventilation, intensive care unit (ICU) stay, and hospital stay in the experimental group were shorter than those in the control group, and the total incidence of adverse reactions and mortality in the experimental group were lower than those in the control group, the differences were statistically significant (P＜0.05). Conclusion On the basis of conventional treatment, the application of Xuebijing Injection for treatment can help to improve the inflammatory indexes of patients with severe acute pancreatitis, which is beneficial to improve the treatment effect, shorten the length of hospitalization, and the curative effect is positive. It is worthy of promotion.

 

Objective To investigate the effect of ultrasound-guided puncture in the treatment of liver abscess. Methods A total of 80 patients with liver abscess in Putian Medical District of the 900 Hospital of the Joint Logistics Support from January 2019 to January 2021 were selected as the research object. They were randomly divided into observation group and control group with 40 patients in each group. The observation group was treated with ultrasound-guided puncture, and the control group was treated with incision and catheter drainage. The treatment effect, operation related indexes and postoperative complications were compared between the two groups. Results The total effective rate index of treatment in the observation group was higher than that in the control group, and the difference was statistically significant (P＜0.05). The time for white blood cells to return to normal index value, time for body temperature to return to normal index value, postoperative extubation time and total hospitalization time in the observation group were shorter than those in the control group, and the differences were statistically significant (P ＜0.05). The total incidence of postoperative complications in the observation group was lower than that in the control group, and the difference was statistically significant (P ＜0.05). Conclusion For the treatment of patients with liver abscess, ultrasound-guided puncture has the advantages of less trauma, good curative effect and low incidence of complications.

 

Objective To investigate the application effect of thrombus aspiration catheter in the emergency interventional treatment of acute myocardial infarction. Methods A total of 70 patients with acute myocardial infarction in Iron Coal General Hospital Liaoning health Industry Group from January 2019 to June 2020 were selected and randomly divided into observation group (35 cases) and control group (35 cases) according to computer random drawing method. The control group was treated with routine emergency interventional therapy, while the observation group was treated with thrombus aspiration catheter on the basis of the control group. The clinical treatment effect, cardiac function and adverse reactions were compared between the two groups. Results The total effective rate of clinical treatment in the observation group was higher than that in the control group, and the difference was statistically significant (P＜0.05). The left ventricular ejection fraction of the observation group was higher than that of the control group, the left ventricular end-systolic diameter and the left ventricular end-diastolic diameter were smaller than those of the control group, and the differences were statistically significant (P＜0.05). The total incidence of adverse reactions in the observation group was lower than that in the control group, and the difference was statistically significant (P＜0.05). Conclusion Compared with the emergency interventional treatment alone, integrating the thrombus aspiration catheter into the treatment of patients with acute myocardial infarction has a better clinical effect. For the cardiac function index of acute myocardial infarction patients, the thrombolytic blood flow improvement effect of myocardial infarction is better, and the treatment safety is high, which is worth promoting.

 

Objective To investigate the application effect of nebulized Budesonide combined with Etimicin in patients with acute exacerbation of chronic bronchitis. Methods A total of 106 patients with acute exacerbation of chronic bronchitis in Beijing Jingmei Group General Hospital from March 2018 to March 2021 were selected as the research objects, and they were divided into the control group (53 cases) and the observation group (53 cases). The control group was treated with Etimicin, and the observation group was treated with Etimicin combined with nebulized Budesonide.The symptom scores, inflammatory factors, lung function and safety of the two groups of patients were compared. Results Before treatment, there was no significant difference in symptom scores, inflammatory factors and pulmonary function between the two groups (P＞0.05). After treatment, the symptom scores of the observation group were lower than those of the control group, the levels of procalcitonin (PCT) and C-reactive protein (CRP) were lower than those of the control group, the percentage of forced vital capacity to the predicted value (FVC%pred), the forced exhalation in the first second. The proportion of air volume (FEV1%pred) and the proportion of peak respiratory flow rate (PEF%pred)were higher than those in the control group, and the difference was statistically significant (P＜0.05). There was no significant difference in the total incidence of adverse reactions between the two groups (P＞0.05). Conclusion Nebulized Budesonide combined with Etimicin in the treatment of patients with acute exacerbations of chronic bronchitis can effectively improve clinical symptoms, relieve inflammation, improve lung function, and has a certain degree of safety.

 

Objective To analyze the expression of Th1/Th2 and Fas/FasL in peripheral blood of patients with toxic diffuse goiter(Graves disease)before and after 131I treatment.Methods Sixty Graves patients diagnosed in Pingxiang People′s Hospital from January to December 2016 were selected as the observation group,and 60 healthy subjects were selected as the control group during the same period.All patients in the observation group received 131I treatment for the first time,and were divided into remission group(54 cases)and recurrence group(6 cases)according to the curative effect after 12 months of follow-up. The changes of Th1/Th2 migration and Fas/FasL expression in peripheral blood of patients before and after treatment were compared. Results Interleukin-12 (IL-12), interleukin-10 (IL-10), IL-12/IL-10 in the observation group were higher than those in the control group, IL-10 in remission group was higher than control group, IL-12、IL-10 in recurrence group were higher than those in the control group, the differences were statistically significant (P＜0.05). There were no significant differences in IL-12, IL-10, IL-12/IL-10 between the recurrence group and the observation group(P＞0.05). Fas and FasL in the observation group were higher than those in the control group, Fas in remission group and recurrence group was higher than that in control group, the differences were statistically significant (P＜0.05). Fas in remission group was lower than that in observation group and recurrence group, the difference was statistically significant (P＜0.05). There were no significant differences in Fas and FasL between the recurrence group and the observation group (P＞0.05). Conclusion After treatment, the immune response of recurrent Graves patients tended to be more Th1,and Fas level increased with the development of Graves disease. It is indicated that curative effect can be assessed according to clinical manifestations combined with the trend of helper T cells and test results of Fas.

 

Objective To investigate the effect of Intensive Insulin therapy combined with Sodium-glucose Transporter 2 Inhibitor on blood glucose fluctuation in patients with brittle diabetes. Methods A total of 82 cases of brittle diabetes admitted to Dalian Fifth People′s Hospital were selected retrospectively from January 2018 to October 2020. They were divided into control group and observation group according to random number table method, with 41 cases in each group. The control group was treated with Intensive Insulin therapy, while the observation group was treated with Intensive Insulin therapy combined with Sodium-glucose Transporter 2 Inhibitor. The plasma glucose and blood glycemic variations, insulin dosage, glycosylated hemoglobin (HbA1c) and hypoglycemia events were compared between the two groups before and after treatment. Results After treatment, the standard deviation of intra day blood glucose, the large amplitude glycemic excursions, the postprandial glycemic excursions, the insulin dosage and HbA1c of observation group were lower than those of control group, the incidence of hypoglycemic events and severe hypoglycemia of observation group were lower than those of control group, the differences were statistically significant (P＜0.05). Conclusion Combination of Sodium-glucose Transporter 2 Inhibitor and Intensive Insulin therapy can significantly improve glucose metabolism in brittle diabetes, and reduce insulin dosage and hypoglycemic events.

 

Objective To compare the clinical effect of low-dose Triamcinolone Acetonide combined with kinesitherapy and local injection of low-dose Triamcinolone Acetonide alone in the treatment of lateral epicondylitis (LE). Methods A total of 60 patients with unilateral LE who were admitted to Zhang Wenwu Medical Clinic in Gaoping District of Nanchong City from June to December 2019 were selected as the study subjects. The patients were divided into experimental group and control group by random number table method, with 30 patients in each group. Patients in the experimental group were treated with low-dose Triamcinolone Acetonide local block therapy + kinesitherapy, while patients in the control group were treated with low-dose Triamcinolone Acetonide simple local block therapy. The pain visual analogue scale (VAS) score and patient-related lateral epicondylitis evaluation (PRTEE) were compared between the two groups before treatment and at 4 and 12 weeks after treatment. The overall response rate and recurrence rate were compared between the two groups at 12 weeks after treatment. Results There were no statistically significant differences in VAS score of tenderness and VAS score of holding pain before and at 4 weeks after treatment between the two groups (P＞0.05). VAS scores of tenderness and holding pain in experimental group were lower than those in control group at 12 weeks after treatment, with statistically significant differences (P＜0.05). VAS scores of tenderness and holding pain at 4 and 12 weeks after treatment in the two groups were lower than those before treatment,the differences were statistically significant(P＜0.05).VAS scores of tenderness and holding pain in the experimental group at 12 weeks after treatment were lower than those at 4 weeks after treatment, with statistically significant differences (P＜0.05). Before treatment, there was no significant difference in PRTEE score between the two groups (P＞0.05). PRTEE scores of the two groups at 4 and 12 weeks after treatment were lower than those before treatment, the differences were statistically significant (P＜0.05). PRTEE scores in the experimental group were lower than those in the control group at 4 and 12 weeks after treatment, with statistically significant differences (P＜0.05). PRTEE score of the experimental group at 12 weeks after treatment was lower than that at 4 weeks after treatment, the difference was statistically significant (P＜0.05). There was no significant difference in the total effective rate between the two groups (P＞0.05). The recurrence rate of the experimental group was lower than that of the control group, the difference was statistically significant (P＜0.05). Conclusion Low-dose Triamcinolone Acetonide combined with kinesitherapy can effectively control the local pain of patients with lateral epicondylitis. The combination of the two treatments can significantly improve the level of elbow function, and reach a stable efficacy, reflecting the advantages of combination of physical and medicine, but the long-term efficacy still needs further study.

 

Objective To explored the clinical effect of bone cement type and biological type artificial hemi hip replacement in the treatment of elderly patients with femoral neck fracture. Methods A total of 90 elderly patients with femoral neck fracture admitted to the Department of Orthopedics in Yangdong District People′s Hospital of Yangjiang City from January 2020 to June 2021 were selected as the study subjects,and they were divided into control group(45 cases) and observation group (45 cases) by random number table method. The control group used biological artificial hemi hip replacement, and the observation group used bone cement artificial hemi hip replacement. Clinical indicators, Harris hip function score, visual analogue scale (VAS) score and postoperative complications were compared between the two groups. Results The operation time of observation group was shorter than that of control group, the intraoperative blood loss and postoperative drainage volume were less than those of control group, the hospital stay was shorter than that of control group, and the weight-bearing time was earlier than that of control group, with statistically significant differences (P＜0.05). The Harris score of the observation group was higher than that of the control group at one month after surgery, and the rate of excellent and good operation effect was higher than that of the control group, with statistically significant differences (P＜0.05). Before surgery, there was no significant difference in VAS score between the two groups (P＞0.05). One month after surgery, VAS score of observation group was lower than that in the control group, the difference was statistically significant (P＜0.05). There was no significant difference in the total incidence of complications between the two groups (P＞0.05). Conclusion Compared with biological type artificial hemi hip replacement, bone cement type artificial hemi hip replacement is more significant in the treatment of senile femoral neck fracture, with advantages such as short operation time, less intraoperative blood loss and postoperative drainage, short hospital stay,and early weight-bearing time, which can effectively improve the short-term effect and reduce postoperative pain.

 

Objective To investigate the clinical effect of fractionated stereotactic radiotherapy combined with temozolomide chemotherapy in the treatment of brain metastases. Methods A total of 50 patients with brain metastases with histopathological evidence and intracranial metastases diagnosed by enhanced MRI were selected from Yichun People′s Hospital from February 2018 to December 2019. According to the random number table method, they were divided into the control group and the study group, with 50 cases in each group. The control group was treated with fractionated stereotactic radiotherapy, the study group was treated with fractionated stereotactic radiotherapy and temozolomide chemotherapy. The total effective rate, total incidence of adverse reactions, Karnofsky score before and after treatment,1-year survival rate and recurrence rate after treatment were compared between the two groups. Results The total effective rate of the study group was higher than that of the control group, the difference was statistically significant (P＜0.05). The total incidence of adverse reactions in study group was lower than that in control group, and the difference was statistically significant (P＜0.05). After treatment, the Karnofsky score of the study group was higher than that of the control group, and the difference was statistically significant (P＜0.05). The recurrence rate of half a year and one year in the study group were lower than those in the control group, and the one-year survival rate was higher than that in the control group, and the differences were statistically significant (P＜0.05). Conclusion Fractional stereotactic radiotherapy combined with temozolomide chemotherapy can improve patients′ Karnofsky score, prolong the survival rate,and reduce the recurrence rate of patients with brain metastases.

 

Objective To investigate the value of circulating tumor cells (CTC) in evaluating the efficacy of chemotherapy in patients with postoperative stage Ⅲcolorectal cancer (CRC). Methods A total of 77 patients with postoperative stage ⅢCRC treated in Department of Oncology, the First People′s Hospital of Jingdezhen City from January 2017 to January 2019 were selected as the research object. 5 ml of peripheral venous blood was collected from patients on fasting in the morning within 1 week before postoperative adjuvant chemotherapy and after 2 courses of adjuvant chemotherapy, and the expression of various types of CTC in peripheral blood was detected to analyze the relationship between positive total CTC before chemotherapy and clinicopathological features. According to the follow-up, patients were divided into stable disease (SD) group (30 cases) and progressive disease (PD) group (47 cases), and the correlation of CTC count changes before and after chemotherapy and the relationship of total CTC count changes after chemotherapy with disease-free survival (DFS) and overall survival (OS) were analyzed. Results Before chemotherapy,there were no statistically significant differences in the total CTC positive rate of patients with different age, gender,degree of differentiation, location, TN stage and with or without hematochezia (P＞0.05). The changes of total CTC, epithelial CTC, interstitial CTC and mixed CTC before and after chemotherapy were negatively correlated with the efficacy of chemotherapy (r=-0.301, r=-0.334, r=-0.281, r=-0.326, P＜0.05). After chemotherapy, the patients were divided into descending group and ascending group according to the trend of total CTC count. The mean DFS and OS of descending group (22.9 and 24.8 months) were longer than those of ascending group (9.0 and 15.7 months), and the differences were statistically significant (P ＜0.05). Conclusion The changes of various types of CTC count before and after chemotherapy can be used to evaluate the chemotherapy efficacy of postoperative stage ⅢCRC patients to a certain extent, and the changes of total CTC count affect the length of DFS and OS.

 

Objective To study the clinical effects of Icotinib Hydrochloride in the treatment of advanced non-small cell lung cancer (NSCLC). Methods A retrospective analysis of 63 patients with stage ⅢB to stage Ⅳadvanced NSCLC who were treated with icotinib hydrochloride in Beijing Huairou Hospital from January 2014 to July 2017. All patients received only icotinib hydrochloride treatment. A total of 63 cases were observed The patient′s clinical characteristics,treatment effects, adverse reactions and survival time. Analyze the relevant influencing factors of the recent efficacy.According to whether the pathological type is adenocarcinoma, a total of 63 patients were divided into adenocarcinoma group (51 cases) and non-adenocarcinoma group (12 cases), and the disease control rate (DCR) and survival curve of the two groups were compared. Results Among the 63 patients, a total of 12 had partial remission (PR), a total of 30 had stable disease (SD), and 21 had disease progression (PD). The objective response rate (ORR) was 19.0%, and the DCR was 66.7%. The time to disease progression (MPFS) was (7.41±3.75) months. The main adverse reactions were rash in 23 cases (36.5%) and diarrhea in 14 cases (22.2%). The occurrence of rash and diarrhea was mainly grade Ⅰand grade Ⅱ, can be relieved after symptomatic treatment. Univariate analysis revealed that the pathological type was the influencing factor of DCR (P＜0.05). The 6-month DCR of the adenocarcinoma group was higher than that of the non-adenocarcinoma group, and the difference was statistically significant (P＜0.05). The survival ccurve of the adenocarcinoma group was better than that of the non-adenocarcinoma group, and the difference was statistically significant(P＜0.05). Conclusion Icotinib Hydrochloride is certainly effective for late NSCLC, especially in patients with adenocarcinoma, and the adverse effects are mild after application, which is worthy of use.

 

Objiective To investigate the value of lung ultrasound in early diagnosis and monitoring of transient tachypnea of the neonate. Methods Sixty children with transient tachypnea admitted to Huaian Maternity and Child Healthcare Hospital Affiliated to Yangzhou University Medical College from July 2018 to June 2019 were selected as the observation group, and sixty healthy newborns with similar gestational age were selected as the control group. In the observation group, lung ultrasound was performed within 6 h and 72 h after birth, respectively, while in the control group, lung ultrasound was performed only within 6 h after birth, the characteristics of lung ultrasound were analyzed.Results Ultrasound examination showed that no consolidation occurred in all the children. Within 6 h after birth, the incidence of abnormal pleural line, disappearance of A-line, existence of B-line, alveolar interstitial syndrome, double lung spot and pleural effusion in the observation group was higher than that in the control group, the differences were statistically significant (P＜0.05). The incidence of abnormal pleural line, disappearance of A-line, existence of B-line,alveolar interstitial syndrome, double lung spot and pleural effusion in the observation group 72 h after birth was lower than that of ultrasound examination within 6 h after birth, the differences were statistically significant (P＜0.05). Conclusion Children with temporary dyspnea were characterized by abnormal pleural line, disappearance of A-line, presence of B-line, alveolar interstitial syndrome, double lung spots, no consolidation and pleural effusion. Pulmonary ultrasound is of great value in early diagnosis and monitoring of temporary dyspnea in neonates.

 

Objective To study the application effect of transabdominal amniotic fluid reduction surgery on improving vaginal delivery in the third trimester of pregnancy. Methods A total of 100 patients with polyhydramnios during the third trimester of pregnancy and indications for termination of pregnancy who were treated in Jiangxi Maternal and Child Health Hospital between January 2020 and January 2021 were selected as the study subjects, and they were divided into a study group and a control group according to the random number table method, with 50 cases in each group. Patients in the control group implemented delivery regimen according to the cervical score, and patients in the study group received delivery regimen according to the cervical score after amniotic fluid reduction surgery. Methods of delivery, incidence of perinatal complications, Apgar score of newborn and hospitalization expenses of delivery were compared between the two groups. Results The vaginal delivery rate in the study group was higher than that in the control group, and the cesarean delivery rate was lower than that in the control group, and the difference was statistically significant (P＜0.05). The total incidence of perinatal complications in study group was lower than that in control group, and the difference was statistically significant (P＜0.05). The Apgar score of the study group was higher than that of the control group, and the hospitalization cost of delivery was lower than that of the control group, and the differences were statistically significant (P＜0.05). Conclusion Transabdominal amniotic fluid reduction surgery for patients with polyhydramnios in the third trimester of pregnancy can increase the vaginal delivery rate, reduce the risk of complications and save the cost of hospitalization.

 

Objective To investigate the effect of magnetic wave knife combined with Levonorgestrel Intrauterine Birth Control System on carbohydrate antigen 125 (CA125)and menstruation in patients with adenomyosis. Methods A total of 84 patients with adenomyosis admitted to Foshan Hospital Affiliated to Guangzhou University of Traditional Chinese Medicine from January 2020 to March 2021 were selected as the study subjects. They were divided into control group and observation group by random number table method, with 42 cases in each group. The control group was treated with Levonorgestrel Intrauterine Birth Control System in uterine cavity, and the observation group was treated with Levonorgestrel Intrauterine Birth Control system after magnetic wave knife treatment. CA125, anti-endometrial antibody(EMAb) and menstruation were compared between the two groups before and 3 months after treatment. Results There was no significant difference in CA125 and EMAb levels between the two groups before treatment (P＞0.05). CA125 and EMAb levels in two groups after treatment were lower than before, and the observation group was lower than that of the control group, the differences were statistically significant (P＜0.05). There were no significant differences in menstrual volume, menstrual days and pain scores between the two groups before treatment (P＞0.05). The observation group after treatment menstrual volume was less than that of the control group, menstrual days shorter than the control group, pain score was lower than that of the control group, the differences were statistically significant (P＜0.05). Conclusion The treatment effect of magnetic wave knife combined with Levonorgestrel Intrauterine Birth Control System in patients with adenomyosis is accurate, which is conducive to reducing the levels of CA125 and EMAb, reducing menstrual volume, shortening menstrual time and reducing menstrual pain. It is worthy of wide clinical application.

Objective To evaluate the relationship between Maternal Critical Care Working Group level of care (MCCWG-LOC) and specific pregnancy outcomes applying the levels of care (LOC) evaluation system recommended by the MCCWG in pregnant women admitted to the intensive care unit (ICU), and to compare MCCWG-LOC and two other early warning scoring systems (acute physiology and chronic health evaluation Ⅱ [APACHE Ⅱ] and obstetric early warning score [OEWS]). Methods A total of 363 pregnant women admitted to the ICU of Suzhou Municipal Hospital from January 2015 to December 2018 were selected for a single center retrospective cohort study. According to the hierarchical monitoring level of MCCWG-LOC, they were divided into the level 1 monitoring group (182 cases), the level 2 monitoring group (103 cases) and the level 3 monitoring group (78 cases). The scores of APACHE Ⅱ, OEWS and specific pregnancy outcomes were compared among the three groups. Further, the level 1 and 2 monitoring groups were taken as the non intensive care group and the level 3 monitoring group was taken as the intensive care group. The discrimination ability of APACHE Ⅱ and OEWS early warning scoring systems for ICU pregnant women in the MCCWG-LOC evaluation system was evaluated by area under curve (AUC) of the receiver operating characteristic(ROC). Results During the study period, 363 pregnant women were admitted to ICU (ICU admission rate was 0.46%)and 3 pregnant women died (maternal mortality rate was 3.83/100 000). Among them, 276 cases (76.03%) were admitted for direct obstetric reasons and 87 cases (23.97%) were admitted for indirect obstetric reasons. Three maternal deaths occurred in the level 3 monitoring group. The total length of stay and ICU stay in the level 3 monitoring group were longer than those in the level 1 and 2 monitoring groups, and the perinatal loss rate and hospitalization expenses in the level 3 monitoring group were higher than those in the level 1 and 2 monitoring groups, the differences were statistically significant (P＜0.05). The APACHE Ⅱscore, APACHE Ⅱpredicted mortality and OEWS score in the level 3 monitoring group were higher than those in the level 1 and 2 monitoring groups, the differences were statistically significant (P＜0.05). Pairwise comparison showed that the OEWS score of the level 3 monitoring group was higher than that of the level 1 and 2 monitoring group, and the OEWS score of the level 2 monitoring group was higher than that of the level 1 monitoring group, the differences were statistically significant (P＜0.05). The APACHE Ⅱscore and APACHEⅡpredicted mortality in the level 3 monitoring group were higher than those in the level 1 and 2 monitoring group, the differences were statistically significant (P＜0.05). There was no significant difference in APACHE Ⅱscore and APACHE Ⅱpredicted mortality between the level 1 monitoring group and the level 2 monitoring group (P＞0.05). APACHE Ⅱand OEWS had a certain ability to distinguish pregnant women in intensive care (ROC AUC=0.808 [95%CI:0.748-0.868]) and 0.847 [95%CI:(0.799-0.894)], and OEWS is higher than APACHE Ⅱ. Conclusion MCCWG-LOC evaluation system is directly related to disease severity, and is highly consistent with the early warning scoring system widely recognized and applied in clinic. The application of this simple evaluation system based on organ support can stratify the monitoring level of obstetric critical patients and improve the comprehensive treatment ability of critically ill pregnant women.

 

Objective To investigate the application effect of Methotrexate combined with Compound Polymyxin B Ointment in the treatment of moderate and severe atopic dermatitis in children. Methods A total of 90 children with atopic dermatitis in the Department of Dermatology, Affiliated Hospital of Jiujiang University and the Department of Pediatrics of Jiujiang Maternal and Child Health Care Hospital from December 2018 to December 2020 were selected as the research objects. They were divided into the experimental group (n=45) and the control group (n=45) by computer grouping method. The control group was treated with Methotrexate. The experimental group was treated with Methotrexate combined with Compound Polymyxin B Ointment. The changes of serum related indexes (interleukin-4 [IL-4], interleukin-13 [IL-13]) and eosinophil levels, the improvement of severity scoring of atopic dermatitis (SCORAD) and eczema area and severity index (EASI) score, the occurrence of adverse reactions after medication and score changes of children′s dermatological life quality index (CDLQI) were compared between the two groups before and after treatment.Results The serum-related indicators such as IL-4 and IL-13 and the level of eosinophils in the experimental group after treatment were lower than those in the control group, the differences were statistically significant (P＜0.05). The SCORAD score, EASI score and CDLQI score in the experimental group after treatment were lower than those in the control group, the differences were statistically significant (P＜0.05). There was no significant difference in the incidence of adverse reactions between the two groups (11.11% [5/45] vs. 6.67% [3/45]). Conclusion Methotrexate combined Compound Polymyxin B Ointment in the treatment of moderately severe atopic dermatitis is effective, which can effectively control the patient′s serum inflammatory biomarkers and eosinophil level, and significantly relieve the clinical symptoms and signs. At the same time, the quality of life of children can be significantly improved, and will not bring serious adverse reactions to children. The effectiveness and safety are high. It is suggested that it can be popularized and applied in clinic as appropriate.

Objective To explore the application effect of maximum Phloroglucinol in the labor process of premature rupture of membranes with poor cervical conditions. Methods From January 2020 to January 2021, 120 pregnant women with premature rupture of membranes admitted to Dalian Women and Children′s Medical Center(Group) who required natural childbirth and cervical Bishop score less than 6 scores were selected as the research objects.According to the sequence of their coming to the hospital, they were assignned to the first maternity ward and other obstetric wards. Among them,60 parturients in the first maternity ward were in the observation group,and they were given Phloroglucinol 200 mg+Diazepam 10 mg. The rest of 60 pregnant women in other obstetric wards were selected as the control group and were only given Diazepam 10 mg. The progress of labor process was observed routinely. The cervical dilatation rate, labor process time, vaginal delivery rate, conversion to cesarean section rate, postpartum hemorrhage, intrauterine infection rate and neonatal Apgar score were compared between the two groups. Results The cervical dilatation rate and vaginal delivery rate in the observation group were higher than those in the control group, the differences were statistically significant (P＜0.05). The rate of conversion to cesarean section and intrauterine infection in the observation group were lower than those in the control group, the differences were statistically significant (P＜0.05). The latency and active period of the first stage of labor in the observation group were shorter than those in the control group, the differences were statistically significant (P＜0.05). The amount of postpartum hemorrhage at 2 hours after delivery in the observation group was less than that in the control group, the difference was statistically significant (P＜0.05). There was no significant difference in the second stage of labor and neonatal Apgar score between the two groups (P＞0.05). Conclusion Maximum Phloroglucinol combined with Diazepam can accelerate the expansion of uterine orifice, shorten the latency and active period of the first stage of labor process, improve the vaginal delivery rate, reduce the conversion rate of cesarean section and the amount of postpartum hemorrhage, and have no significant effect on the outcome of newborns.

 

Objective To explore the application effect of continuous quality improvement in vaginal delivery puerpera and its influence on the rate of lateral perineal resection. Methods A total of 1743 vaginal delivery puerperae admitted to the First Affiliated Hospital of Guangzhou Medical University from January 2019 to December 2019 were selected as the control group, and 863 vaginal delivery puerperae admitted to the First Affiliated Hospital of Guangzhou Medical University from January 2020 to December 2020 as the observation group. The control group received routine management methods, and the observation group received additional continuous quality improvement management methods based on routine midwifery interventions. The rate of lateral perineal resection during delivery, the rate of perineal wound infection, the rate of adverse neonatal outcomes and the total satisfaction of intervention were compared between the two groups. Results The lateral perineal resection rate in the observation group was lower than that in the control group, and the difference was statistically significant (P＜0.05). There was no significant difference in the rate of perineal wound infection between the two groups (P＞0.05). There was no significant difference in the total incidence of adverse outcomes between the two groups (P＞0.05). The total satisfaction of pregnant women in the observation group was higher than that in the control group, and the difference was statistically significant (P＜0.05). Conclusion The application of continuous quality improvement nursing management methods during delivery of the puerperae can effectively reduce the rate of lateral perineal resection and the infection of the perineal wound, thereby increasing the satisfaction from puerperae. It is worthy of clinical promotion and application.

 

Objective To compare the application effect of Cyclopentolate Hydrochloride and Tropicamide in the treatment of hyperopia children with optometry and mydriasis. Methods A total of 78 hyperoptometry children (156 eyes)underwent dilation optometry admitted to Yichun Maternal and Child Health Hospital from February 2020 to February 2021 were selected as the research objects. They were divided into observation group and control group according to random number table method, with 39 cases (78 eyes) in each group. Children in the observation group were dilated with Cyclopentolate Hydrochloride during optometry, and children in the control group were dilated with Tropicamide.The diopter results of the two groups were analyzed, and the changes of pupil diameter and residual adjustment volume were compared between the two groups before medication, 20, 40, 60 min and 24, 48 h after medication, and the incidence of adverse reactions between the two groups was analyzed. Results There was no significant difference in diopter between the two groups (P＞0.05). There was no significant difference in pupil diameter between the two groups before medication (P＞0.05). The pupil diameter of the observation group at 40 min after medication was smaller than that of the control group, and the pupil diameters of the observation group at 24 and 48 h after medication were larger than those of the control group, with statistically significant differences (P＜0.05). There was no significant difference in the residual regulation before medication between the two groups (P＞0.05). The residual regulatory amounts of the two groups at 20, 40, 60 min and 24 h after medication were lower than those before medication, with statistically significant differences (P＜0.05). The residual regulatory amounts in observation group at 20, 40, 60 min and 24 h after medication were higher than those in control group, and the differences were statistically significant (P＜0.05). The total incidence of adverse reactions in the observation group was lower than that in the control group, and the difference was statistically significant (P＜0.05). Conclusion The mydriatic effect of Cyclopentolate Hydrochloride Eye Drops is similar to that of Tropicamide, but its cycloplegia effect and safety are better.

 

Objective To compare the effects of total tonsillectomy (TE) and partial tonsillectomy (TT) in the treatment of obstructive sleep apnea hypopnea syndrome in children (OSAHS). Methods A total of 200 children with OSAHS treated in Jiangxi Children′s Hospital from January 2021 to June 2021 were analyzed retrospectively. They were divided into control group (140 cases) and observation group (60 cases). The children in the two groups were assisted by lowtemperature plasma. The children in the control group were treated with TE and the children in the observation group were treated with TT. The surgical effect, sleep quality, apnea index (AH), hypopnea index (HI), respiratory event related microawakefulness index (MAI), blood gas index and incidence of complications of the two groups were compared.Results There was no significant difference in the total effective rate between the two groups (P＞0.05). After operation,the score of specific quality of life questionnaire (OSA-18) in the observation group was lower than that in the control group, the difference was statistically significant (P＜0.05). AHI, HI and MAI indexes in the observation group were lower than those in the control group, the differences were statistically significant (P＜0.05). After operation, the pH value and arterial partial pressure of oxygen (PaO2) in the observation group were higher than those in the control group, the differences were statistically significant (P＜0.05). The incidence of complications in the observation group was lower than in the control group, the difference was statistically significant (P＜0.05). Conclusion TT is effective for children with OSAHS, with less bleeding, less pain and fewer complications.

 

Objective To investigate the clinical effect of protraction combined with expansion in the treatment of 8-11 year old children with skeletal class Ⅲmalocclusion in mixed dentition. Methods Forty-eight children with skeletal class Ⅲmalocclusion (maxillary deficiency, normal mandibular development or mild mandibular excess) in mixed dentition who were treated at Nanchang First Hospital from June 2015 to December 2019 were selected as the research subjects. According to age, the children were divided into 8-9 year old group and ＞9-11 year old group, with 24 children in each group. Both groups of children were treated with protraction and expansion. Lateral cephalogram, recovery effect and related physiological structural changes were compared between the two groups. Results There were no statistically significances in sella-nasion-B (SNB) and lower incisor-mandibular plane (L1-MP) between the two groups at 6 months after treatment (P＞0.05). At 6 months after treatment, the sella-nasion-A (SNA), point A-nasion-point B(ANB), sella-nasion and palatal plane (SN-PP), mandibular plane-frankfurt horizontal plane angle (MP-FH) and upper incisor/sella-nasion (U1-SN) were larger than those before treatment, and angles between upper and lower central incisors (U1-L1) were smaller than those before treatment in the two groups. At 6 months after treatment, the SNA, the ANB, U1-SN and SN-PP in 8-9 year old group were larger than those in the ＞9-11 year old group, and the U1-L1 was smaller than that in the ＞9-11 year old group, the differences were statistically significant (P＜0.05). There was no statistically significance in MP -FH between the two groups at 6 months after treatment (P＞0.05). The effective recovery rate in 8-9 year old group was higher than that in the ＞9-11 year old group at 6 months after treatment, the difference was statistically significant (P＜0.05). The length of soft palate at 6 months after treatment in the two groups was shorter than that before treatment, and nasopharyngeal inner diameter at 6 months after treatment in the two groups was longer than that before treatment, the differences were statistically significant (P＜0.05). The nasopharyngeal inner diameter of 8-9 year old group at 6 months after treatment was longer than that of the ＞9-11 year old group,the difference was statistically significant (P＜0.05). Conclusion Protraction combined with expansion can effectively improve skeletal class Ⅲmalocclusion in 8-11 year old children in mixed dentition, and the treatment effect is better in 8-9 year old children.

 

Objective To investigate and analyze the application effect of rigid oxygen permeable contact lens (RGP) in the treatment of children with anisometropic amblyopia. Methods From April 2019 to April 2020, 30 children with anisometropic amblyopia were randomly divided into RGP group (n=15) and conventional group (n=15). The RGP group used RGP for vision correction. The patients in the conventional group wore frame glasses for vision correction. The standard logarithmic visual acuity chart was used to evaluate the visual acuity correction before glasses, 1, 6, 12 months after treatment. The visual acuity and therapeutic effect of RGP group and conventional group were recorded and compared before glasses, 1, 6, 12 months after treatment. Results The total effective rate of RGP group was significantly higher than that of conventional group, the difference was statistically significant (P＜0.05). There was no significant difference of the visual, acuity between the two groups before treatment (P＞0.05), but the visual acuity of the two groups after 1, 6 and 12 months after treatment was lower than before treatment, and the visual acuity of the RGP group after 1, 6 and 12 months after treatment was higher than that of the conventional group, the difference was statistically significant (P＜0.05). There was no significant difference in the incidence of complications between the two groups (P＞0.05).Conclusion Compared with the use of frame glasses, the application of rigid oxygen permeable contact lenses can improve the treatment effect of children with anisometropic amblyopia, improve the visual acuity of children, with good safety, which is worthy of clinical application and promotion.

 

Objective To observe the clinical effect of Xiaoke Tongluo Decoction combined with Chinese herbal fumigation and washing on type 2 diabetic foot. Methods A total of 90 patients with type 2 diabetes admitted to Gaomi Traditional Medicine Hospital from July to August 2020 were randomly divided into the treatment group and the control group, with 45 cases in each group. The treatment group was given Xiaoke Tongluo Decoction combined with Chinese medicine fumigation, the control group was given Mecobalamin and Epalrestat orally for 1 month. The curative effect of Xiaoke Tongluo Decoction combined with traditional Chinese medicine (TCM) fumigation was evaluated by statistical analysis of common peroneal nerve conduction velocity and TCM symptom integral in two groups. Results After treatment, the conduction velocity of common peroneal nerve and the score of clinical symptoms in treatment group were higher than those in control group, the total effective rate of the treatment group was higher than that of the control group, the differences were stastically significance (P＜0.05). Conclusion Xiaoke Tongluo Decoction combined with Chinese medicine fumigation and washing can effectively improve the nerve transfer velocity and clinical symptoms of lower limbs in patients with type 2 diabetic foot.

 

Objective To investigate the effect of intradermal needle combined with transcranial magnetic stimulation in patients with dysphagia after stroke. Methods A total of 60 patients with poststroke swallowing dysfunction, admitted from the First Department of Acupuncture and Rehabilitation of the First Affiliated Hospital of Anhui University of Chinese Medicine from June 2020 to February 2021, were selected as the research subjects and divided into control group (20 cases), intradermal needle group (20 cases) and combined group (20 cases).The control group protocol was the basic treatment of stroke and swallowing training for 3 weeks, the endothelial needle group was treated with 3 weeks to the control group, and the combined group was treated with transscranial magnetic stimulation to the group for 3 weeks.The changes in the avada drinking water test (WST) and the modified swallowing capacity evaluation scale (MMASA)scores after 3 weeks of treatment in the three groups were compared. Results After treatment, the WST scores of the three groups were lower than those before the treatment, and the differences were statistically significant (P＜0.05). After treatment, the WST score of the intradermal needle group was compared with the control group, and the difference was not statistically significant (P＞0.05). After treatment, the WST score of the combined group was lower than that of the control group and the intradermal needle group, the difference was statistically significant (P＜0.05). After treatment, the MMASA scores of the three groups were higher than those of this group before treatment, and the differences were statistically significant (P＜0.05). After treatment, the MMASA scores of the intradermal needle group and the combined group were higher than those of the control group, and the differences were statistically significant (P＜0.05). After treatment, the MMASA score of the combined group was higher than that of the intradermal needle group, the difference was statistically significant (P＜0.05). Conclusion Intradermal acupuncture is beneficial to the recovery of swallowing function after stroke, and combined with TRANSCranial magnetic stimulation is more effective.

 

Objective To explore the effect of dilution method on the interpretation of multi-karyotypes in anti-nuclear antibody (ANA). Methods From June to August 2019, 56 nuclear composite karyotypes and 10 nuclear monokaryotypes from patients admitted to Nanjing Drum Tower Hospital were collected. Western blotting was used to detect anti-nuclear antibody (IgG) spectra, and indirect immunofluorescence method was used to detect anti-nuclear antibody immunoglobulin G (IgG) diluted at 1∶100, 1∶1000, and 1∶10 000. The maximum dilution titer of fluorescence was determined, and the differences of karyotype and titer interpretation results before and after dilution were compared combined with ANA spectrum results. Results There was no change in karyotype and titer of 10 nuclear mono-karyotype samples before and after dilution. Among 56 nuclear compound karyotypes, 8 cases (14.2%) were increased, 3 cases(5.4%) were decreased, and 45 cases (80.4%) remained unchanged. The titer analysis showed that 23 cases (41.1%)were increased, 8 cases (14.2%) were decreased, 2 cases (3.6%) were partially increased and partially decreased, and 23 cases (41.1%) had no change. This result was more correlated with ANA spectrum results. Conclusion The method of dilution can help to determine the karyotypes and titers of nuclear multi-karyotypes, so as to improve the accuracy of the results.

 

Objective To analyze the clinical significance of immunoglobulin and CD3+, CD4+, CD19+, CD4+/CD8+ in the condition and prognosis of children with refractory mycoplasma pneumonia. Methods A total of 95 children with mycoplasma pneumonia admitted to Anshan Central Hospital from January 2020 to May 2021 were divided into refractory group (35 cases) and ordinary group (60 cases) according to the severity of disease. The refractory group was refractory, and the ordinary group was common. Another 50 healthy children were selected as the control group. The levels of immunoglobulin and CD3+, CD4+, CD19+, CD4+/CD8+ in the three groups were compared. Children with refractory mycoplasma pneumonia were divided into good prognosis group and bad prognosis group according to prognosis, and the immune indexes of the two groups were compared. Results The levels of CD3+, CD4+ and CD4+/CD8+ in the mycoplasma pneumonia group were lower than those in the control group, while the levels of CD8+, CD19+, immunoglobulin A (IgA), immunoglobulin G (IgG) and immunoglobulin M (IgM) were higher than those in the control group, the differences were statistically significant (P＜0.05). The levels of CD3+, CD4+ and CD4+/CD8+ in the refractory group were lower than those in the normal group, while the levels of CD8+, CD19+, IgA, IgG and IgM were higher than those in the normal group, the differences were statistically significant (P＜0.05). The levels of CD3+, CD4+ and CD4+/CD8+ in the good prognosis group were higher than those in the adverse group, while the levels of CD8+, CD19+, IgA, IgG and IgM were lower than those in the adverse group, the differences were statistically significant (P＜0.05). Conclusion Cellular immunological indicators and humoral immune indicators can effectively predict the severity of the disease in children with mycoplasma pneumoniae pneumonia, and have high application value.

 

Objective To establish an infectious disease index forecast model in Zhuhai city to provide ideas for the forecast of infectious disease risk. Methods The lower, midline and upper control limits of Statistical Process Control(SPC) were used to divide the city′s 2014-2017 influenza-like case ratio, hand-foot-mouth disease and other infectious diarrhea risk grades in the weekly measurement unit from 2014 to 2017 (Breteau index was judged by 5, 10, 20). Long and short-term memory neural network model (LSTM) and autoregressive integrated moving average model (ARIMA)were used to predict the data of 15-19 weeks in 2018. The infectious disease index was calculated and compared the predicted value with the actual value to evaluate the prediction consistency. Results In the LSTM model of hand, foot and mouth disease incidence in Zhuhai, the MSE of the test set was 9.0441, the RMSE was 3.0073, the MSE of the training set was 1.1812, and the RMSE was 1.0868. The remaining models performed well on the training set and test set, and there was no overfitting phenomenon. Comparing the risk index level prediction with the actual value, the prediction agreement rate was 96.0%. Conclusion It was feasible to use SPC to classify risk levels and to use LSTM to construct infectious disease index prediction models.

 

Objective To explore the effect of cluster nursing in the treatment of local complications of severe acute pancreatitis by CT guided puncture. Methods A total of 60 patients with severe acute pancreatitis who underwent CTguided puncture treatment and were admitted to the Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine from January 2018 to January 2020 were selected as the research objects, and were divided into the control group (32 cases) and the observation group (28 cases) by random coin toss method. The control group carried out traditional nursing care, and the observation group carried out clustered nursing. The two groups were compared with local complications, abdominal pain and bloating recovery time, body temperature returning to normal time, first defecation time, hospitalization time, etc. Results The total incidence of local complications in the observation group was higher than that in the control group, and the difference was statistically significant (P＜0.05). The recovery time from abdominal pain and bloating, time to normal body temperature, first defecation time, and hospital stay of observation group were shorter than those of the control group, and the differences were statistically significant (P＜0.05). Conclusion For patients with severe acute pancreatitis, during CT guided puncture treatment, cluster nursing intervention can reduce the occurrence of local complications, shorten the time of symptom regression, and has high clinical application value.

 

Objective To explore the application effect of WeChat continuous care on patients with ovarian cancer after chemotherapy. Methods A total of 50 patients with ovarian cancer admitted to jiujiang Third People′s Hospital from July 2015 to June 2017 were selected as the study subjects, and they were divided into control group (25 cases) and observation group (25 cases) by random number table method. The control group received routine nursing, and the observation group received WeChat continuous nursing for 4 weeks. The chemotherapy compliance, self-care ability,quality of life and nursing satisfaction of the two groups were compared. Results The chemotherapy compliance of observation group was higher than that in the control group, and the difference was statistically significant (P＜0.05). After intervention, the scores of exercise of self-care agency scale (ESCA) and the MOS item short from health survey (SF-36)were higher than those before intervention, ESCA and SF-36 scores in observation group were higher than those in control group after intervention, the differences were statistically significant (P＜0.05). The nursing satisfaction scores of health guidance, operation techniques, follow-up methods and service attitude in the observation group were higher than those in the control group, with statistically significant differences (P＜0.05). Conclusion WeChat continuous nursing can improve the chemotherapy compliance and self-care ability of ovarian cancer patients, improve the quality of life, and improve the nursing satisfaction.

 

Objective To explore the effect of narrative nursing on the fear of cancer recurrence in patients with head and neck cancer radiotherapy. Methods Atotal of 60 patients in the Department of Radiotherapy for Head and Neck Cancer in Zhejiang Cancer Hospital from January 2020 to March 2021 were selected as the research subjects. According to random number table method, patients were divided into control group and observation group, 30 cases in each group. The control group was given routine nursing, and the observation group was given narrative nursing intervention. The level of cancer recurrence fear and psychological distress were compared between the two groups before and after intervention. Results Before intervention, there were no significant differences in fear of cancer recurrence score and distress thermometer (DT) score of psychological pain between the two groups (P＞0.05). After intervention,the fear score of cancer recurrence in observation group was lower than that in control group, the difference was statistically significant (P＜0.05). After intervention, the DT score of psychological pain in the observation group was lower than that in the control group, the difference was statistically significant (P＜0.05). After intervention, the proportions of poor relationship with medical staff, depression, fear, worry, stress, sleep problems, poor eating and fatigue in the observation group were lower than those in the control group, the differences were statistically significant (P＜0.05). Conclusion Narrative nursing intervention can reduce the level of fear of cancer recurrence in patients with head and neck cancer radiotherapy and reduce the level of psychological pain, which is worthy of application and promotion.

 

Objective To discuss the application effect of multi-dimensional rehabilitation nursing with traditional Chinese medicine characteristics in patients with lumbar intervertebral disc herniation (LDH). Methods A total of 82 patients with LDH who were admitted to the Fourth Affiliated Hospital of Nanchang University from October 2018 to October 2020 were selected as the research objects, and were divided into the control group (n=41 cases) and the observation group (n=41 cases), all underwent conservative treatment, the control group underwent conventional rehabilitation nursing, the observation group applied traditional Chinese medicine characteristic multi-dimensional rehabilitation nursing on the basis of the control group, the pain status, functional rehabilitation level, anxiety and depression level and sleep quality of the two groups were compared. Results The pain in the observation group was lighter than that in the control group, and the difference was statistically significant (P＜0.05). Before nursing, there was no statistically significant difference between the two groups in the Japanese Orthopedic Association score (JOA) and Oswestry disability index (ODI) (P＞0.05). After nursing, the JOA score of the two groups was higher than that before nursing, and the ODI score was lower than before nursing, the JOA score of the observation group was higher than that of the control group, and the ODI score was lower than that of the control group, the differences were statistically significant (P＜0.05).Before nursing, there was no statistically significant difference between the two groups of self-rating anxiety scale (SAS)and depression self-rating scale (SDS) scores (P＞0.05). After nursing, the SAS score and SDS score of the two groups were lower than those before nursing, and the observation group was lower than that of the control group, the differences were statistically significant (P＜0.05). The overall sleep quality of the observation group was better than that of the control group, and the difference was statistically significant (P＜0.05). Conclusion The characteristic multi-dimensional rehabilitation nursing of traditional Chinese medicine is used for the treatment of LDH patients, and the effect is definite, not only the pain condition is improved, the functional rehabilitation level is improved, but also the anxiety and depression are improved, which is conducive to the improvement of sleep quality.

 

Objective To explore the effect of Omaha system in patients with chronic heart failure. Methods A total of 80 patients with chronic heart failure admitted to Jinzhou Central Hospital from February 2018 to March 2020 were selected as the research objects, and they were divided into the control group and the observation group according to lottery method, with 40 patients in each group. Patients in the control group received routine care, and patients in the observation group received care based on the Omaha system. The distribution of nursing problems, the effectiveness evaluation of nursing problems and quality of life score were compared between the two groups. Results Three months after discharge, the incidence of nursing problems in the fields of social psychology, physiology and health-related behavior in the control group were higher than those in the same group during hospitalization, the differences were statistically significant (P＜0.05). Three months after discharge, the incidence of nursing problems in the fields of social psychology, physiology and health-related behavior in the observation group were lower than those in the control group,the differences were statistically significant(P＜0.05).At discharge,scores of mental state,respiratory state,pain,circulatory system, nutritional status, physical activity, self-care and drug abuse nursing problems in the two groups were higher than those in the same group on the first day of admission, the differences were statistically significant (P＜0.05). At discharge, the scores of mental state, respiratory state, pain, circulatory system, nutritional status, physical activity,self-care and drug abuse nursing problems in the observation group were higher than those in the control group, the differences were statistically significant (P ＜0.05). Three months after discharge, the scores of clinical symptoms,physical activity and emotional state in the two groups were lower than those in the same group, the differences were statistically significant (P＜0.05). Three months after discharge, the clinical symptoms, physical activity and emotional state scores of patients in the observation group were lower than those in the control group, the differences were statistically significant (P＜0.05). Conclusion Omaha system application and chronic heart failure patients can reduce the incidence of nursing problems, improve the quality of life of patients, worthy of clinical application.

 

Objective To study the application effect of nursing intervention based on cognitive and health behavior change theory on patients with gestational diabetes mellitus. Methods A total of 85 patients with gestational diabetes mellitus who were treated in Shangrao Maternal and Child Health Hospital from February 2018 to January 2021 were selected as the research subjects, they were divided into intervention group (43 cases) and control group (42 cases) according to the random number table method. The control group was given routine nursing, and the intervention group was given routine nursing combined with nursing intervention based on cognitive and health behavior change theory.The self-management efficacy (Chinese version of diabetes management self-efficacy scale [C-DMSES]) and blood glucose control (fasting plasma glucose [FPG], 2 h postprandial blood glucose [2 h PG], glycosylated hemoglobin [HbA1c])of the two groups were compared before intervention and after 9 weeks of intervention. At follow-up until delivery, the total incidence rate of adverse delivery outcomes was compared between the two groups. Results After 9 weeks of intervention, the C-DMSES scores of the two groups were higher than those before intervention, the C-DMSES scores of intervention group were higher than those of control group, the differences were stastically significant (P＜0.05). After 9 weeks of intervention, the levels of FPG, 2 h PG, and HbA1c were lower than those before intervention, the differences were stastically significant (P＜0.05). The levels of FPG, 2 h PG, and HbA1c in intervention group after 9 weeks of intervention were lower than those in control group, the differences were stastically significant (P＜0.05). The total incidence rate of adverse delivery outcomes in intervention group was lower than that in control group, the difference was stastically significant (P＜0.05). Conclusion Nursing intervention based on cognitive and health behavior change theory can improve the self-management efficacy and effectively control the blood glucose level of pregnant women with gestational diabetes mellitus, and it is beneficial to the prevention of adverse delivery outcomes.

 

Objective To explore the effect of dual-heart nursing combined with relaxation training in patients with chronic heart failure (CHF). Methods A total of 70 CHF patients admitted to Pingxiang People′s Hospital from June 2019 to June 2021 were selected as the research objects, they were divided into control group and observation group according to random number table method, with 35 cases in each group. The control group took routine intervention,and the observation group took double-heart nursing combined with relaxation training on the basis of routine intervention for 1 week. The anxiety, depression, quality of life, readmission rate, complications and total nursing satisfaction were compared between the two groups. Results There were no statistically significances between the two groups in the scores of 36-item short form health survey (SF-36) before intervention (P＞0.05). The SF-36 score of the observation group after intervention was higher than that of the control group, the difference was statistically significant(P＜0.05). There were no statistically significances in the scores of the self-rating anxiety scale (SAS) and the selfrating depression scale (SDS) between two groups before intervention (P＞0.05). The SAS and SDS of the observation group after intervention were lower than those of the control group, the differences were statistically significant (P＜0.05). The readmission rate and total complication rate of the observation group were lower than those of the control group, the differences were statistically significant (P＜0.05). The total nursing satisfaction of the observation group was higher than that of the control group, the difference was statistically significant (P＜0.05). Conclusion Double-heart nursing combined with relaxation training can reduce anxiety and depression in CHF patients, improve the quality of life, reduce rehospitalization and complications, and improve the prognosis of patients and increase nursing satisfaction.

 

Objective To investigate the application effect of holistic nursing in weight loss for obese patients with endocrine disorders. Methods From May 2019 to May 2021, 160 obese patients with endocrine disorders admitted to the Department of Gastroenterology, People′s Hospital of Yangdong District in Yangjiang City were selected as the research objects, and were divided into the control group (80 cases) and the observation group (80 cases) by random number table method, both groups were treated with endocrine regulation, the control group was given routine care, and the observation group was given holistic care on the basis of the control group. The efficacy of weight loss, compliance of weight loss nursing behavior, nursing satisfaction, self-rating anxiety scale (SAS) score and self-rating depression scale(SDS) score before and after intervention were compared between the two groups. Results The total effective rate of weight loss and the rate of compliance of weight loss in the observation group were higher than that of the control group, the differences were statistically significant (P＜0.05). Before intervention, there were no statistically significant differences in SAS and SDS scores between the two groups (P＞0.05). After intervention, the SAS and SDS scores of the two groups were lower than those before intervention, and the SAS and SDS scores of the observation group were lower than those of the control group, the differences were statistically significant (P＜0.05). The nursing satisfaction of the observation group was higher than that of the control group, and the difference was statistically significant (P＜0.05). Conclusion The application of holistic nursing to obese patients with endocrine disorders can improving the outcome of weight loss, enhancing the compliance of patients with weight loss medical care, reducing negative emotions and improving nursing satisfaction.

 

Objective To explore the effect of self-efficacy intervention in patients after percutaneous coronary intervention (PCI). Methods A total of 82 patients admitted to the Second People′s Hospital of Zhaoqing City after PCI from July 2020 to June 2021 were selected as the study subjects. They were divided into the intervention group and the control group by random number table method, with 41 patients in each group. The control group received routine nursing intervention after PCI, and the intervention group received self-efficacy intervention on the basis of the control group.The self-efficacy, self-management ability, cardiac rehabilitation and the incidence of adverse cardiovascular events were compared between the two groups before and after the intervention. Results Before intervention, there were no statistically significant differences in the scores of self-efficacy scale (GSES) and coronary heart disease self-management scale (CSMS) between the two groups (P＞0.05). After intervention, the GSES and CSMS scores of the two groups were higher than those before intervention, the differences were statistically significant (P ＜0.05). After intervention, the scores of GSES and CSMS in the intervention group were higher than those in the control group, the differences were statistically significant (P＜0.05). After intervention, the 6-minute walking test (6MWT) distance of patients in the intervention group was longer than that in the control group, the left ventricular ejection fraction (LVEF) was higher than that in the control group, and the total incidence of adverse cardiovascular events was lower than that in the control group, the differences were statistically significant (P＜0.05). Conclusion Self-efficacy intervention can effectively improve self-efficacy and disease self-management ability of patients after PCI, promote cardiac function rehabilitation,and reduce the overall incidence of postoperative adverse cardiovascular events.

 

Objective To explore the application effect of individualized exercise training combined with airway nursing in elderly patients with acute exacerbation of chronic obstructive pulmonary disease and the influence of lung function exercise tolerance quality of life. Methods A total of 80 elderly patients with acute exacerbation of chronic obstructive pulmonary disease admitted to the Department of Respiratory Medicine, Zhongshan Hospital affiliated to Dalian University from February 2019 to January 2021 were selected as the study subjects. The patients were divided into study group (40 cases) and control group (40 cases) by random number table method. The study group carried out individualized exercise training combined with airway nursing program, and the control group carried out routine nursing. Lung function, exercise tolerance, quality of life and incidence of complications were compared between the two groups. Results The scores of vitality, body pain, physical function, physiological function, general health, social function, mental health and emotional role of patients in the study group were higher than those in the control group, and the differences were statistically significant (P＜0.05). There were no significant differences in forced vital capacity, peak expiratory flow rate, forced expiratory volume in the first second and exercise tolerance between the two groups before nursing (P＞0.05). After nursing, forced vital capacity, expiratory peak flow rate, forced expiratory volume in the first second and exercise tolerance in the two groups were higher than those before nursing, with statistically significant differences (P＜0.05). The forced vital capacity, expiratory peak flow rate, forced expiratory volume in the first second and exercise tolerance of patients in the study group were higher than those in the control group after nursing, and the differences were statistically significant (P＜0.05). The total incidence of complications in study group was lower than that in control group, and the difference was statistically significant (P＜0.05). Conclusion Individualized exercise training combined with airway nursing can effectively improve lung function, exercise tolerance and quality of life in elderly patients with acute exacerbation of chronic obstructive pulmonary disease.