Objective To compare the clinical effect of low-dose Triamcinolone Acetonide combined with kinesitherapy and local injection of low-dose Triamcinolone Acetonide alone in the treatment of lateral epicondylitis (LE). Methods A total of 60 patients with unilateral LE who were admitted to Zhang Wenwu Medical Clinic in Gaoping District of Nanchong City from June to December 2019 were selected as the study subjects. The patients were divided into experimental group and control group by random number table method, with 30 patients in each group. Patients in the experimental group were treated with low-dose Triamcinolone Acetonide local block therapy + kinesitherapy, while patients in the control group were treated with low-dose Triamcinolone Acetonide simple local block therapy. The pain visual analogue scale (VAS) score and patient-related lateral epicondylitis evaluation (PRTEE) were compared between the two groups before treatment and at 4 and 12 weeks after treatment. The overall response rate and recurrence rate were compared between the two groups at 12 weeks after treatment. Results There were no statistically significant differences in VAS score of tenderness and VAS score of holding pain before and at 4 weeks after treatment between the two groups (P＞0.05). VAS scores of tenderness and holding pain in experimental group were lower than those in control group at 12 weeks after treatment, with statistically significant differences (P＜0.05). VAS scores of tenderness and holding pain at 4 and 12 weeks after treatment in the two groups were lower than those before treatment,the differences were statistically significant(P＜0.05).VAS scores of tenderness and holding pain in the experimental group at 12 weeks after treatment were lower than those at 4 weeks after treatment, with statistically significant differences (P＜0.05). Before treatment, there was no significant difference in PRTEE score between the two groups (P＞0.05). PRTEE scores of the two groups at 4 and 12 weeks after treatment were lower than those before treatment, the differences were statistically significant (P＜0.05). PRTEE scores in the experimental group were lower than those in the control group at 4 and 12 weeks after treatment, with statistically significant differences (P＜0.05). PRTEE score of the experimental group at 12 weeks after treatment was lower than that at 4 weeks after treatment, the difference was statistically significant (P＜0.05). There was no significant difference in the total effective rate between the two groups (P＞0.05). The recurrence rate of the experimental group was lower than that of the control group, the difference was statistically significant (P＜0.05). Conclusion Low-dose Triamcinolone Acetonide combined with kinesitherapy can effectively control the local pain of patients with lateral epicondylitis. The combination of the two treatments can significantly improve the level of elbow function, and reach a stable efficacy, reflecting the advantages of combination of physical and medicine, but the long-term efficacy still needs further study.