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Quick Search     Adv Search 2022 Vol. 29, No. 1 Published: 2022-01-08   4 Clinical effect of blade needle combined with Taohong Siwu Decoction in the treatment of mixed cervical spondylosis ZENG Wenbi MAI Shuyan PAN Qingdong▲ LI Wenchun Objective To investigate the clinical effect of blade needle combined with Taohong Siwu Decoction in the treatment of mixed cervical spondylosis. Methods A total of 55 patients with mixed cervical spondylosis treated in Shunde Hospital of Guangzhou University of Traditional Chinese Medicine from January 2019 to September 2020 were selected as the research objects. According to random number table method，they were divided into experimental group(27 cases) and control group (28 cases). The control group was treated with physical factors and manipulation，and the experimental group was treated with blade needle combined with Taohong Siwu Decoction. After treatment，visual analog scale (VAS)，neck disability index (NDI) and total effective rate were compared between the two groups. Results After treatment，VAS score and NDI score of the experimental group were lower than those of the control group，and the total effective rate was higher than that of the control group，with statistical significances (P＜0.05). Conclusion The blade needle combined with Taohong Siwu Decoction has more advantages in relieving pain and improving dysfunction in patients with mixed cervical spondylosis，and has better clinical effect. 2022 Vol. 29 (1): 4-7 [Abstract] ( 66 ) HTML (1 KB)  PDF (579 KB)  ( 43 ) 8 Effect of pre-hospital emergency treatment on the quality of treatment of acute myocardial infarction with left heart failure YANG Leilei Objective To investigate the effect of different pre-hospital emergency treatment on the quality of acute myocardial infarction with left heart failure. Methods A total of 120 patients with acute myocardial infarction complicated with left heart failure admitted to Xuzhou Emergency Medical Center from March 2017 to November 2020 were selected retrospectively as the research objects，and divided into group A (36 cases)，group B (42 cases)，and group C (42 cases) according to different pre-hospital emergency treatment methods. Patients in group A were brought to the hospital by their family members without any pre-hospital emergency treatment. Patients in group B and C were transported to the hospital by 120 ambulance. Patients in group B received first aid treatment during the transportation to the hospital. Patients in group C received first aid treatment on site and were transferred to the hospital by ambulance after their condition stabilized. The hospital treatment time，length of stay，blood gas index，creatine kinase isoenzyme (CK-MB)，D-dimer (D-D) and clinical efficacy were compared among three groups. Results The in-hospital treatment time of group B and group C were (97.5±23.8) min and (90.6±22.7) min，respectively，which was shorter than that of group A (127.3±25.1) min，and the differences were statistically significant (P＜0.05). The hospitalization time of group B and C was (4.3±1.1) d and (4.1±0.9) d，respectively，which was shorter than that of group A (5.7±1.2) d，and the differences were statistically significant (P ＜0.05). There was no statistically significant difference between the hospital treatment time and hospital stay of group B and group C (P＞0.05). The pH and PO2 of group B and C before and after treatment in the hospital were higher than those of group A，and the difference was statistically significant (P＜0.05)，the partial pressure of carbon dioxide (PCO2)，CK-MB，D-D before and after treatment in the hospital of group B and C were lower than group A，the differences were statistically significant (P＜0.05). The pH and PO2 of group B before and after treatment in the hospital were lower than those of group C，while PCO2，CK-MB，and D-D were higher than those of group C，the differences were statistically significant (P＜0.05). The total effective rate of group C was higher than that of group A，the difference was statistically significant (P＜0.05). Conclusion Different pre-hospital emergency methods have different effects on the quality of treatment of acute myocardial infarction with left heart failure. The prehospital emergency mode of emergency treatment at the scene，the patient′s hospital treatment time and hospital stay are shorter，blood gas indicators are better，CK-MB and DD levels are lower，clinical efficacy is better. 2022 Vol. 29 (1): 8-12 [Abstract] ( 50 ) HTML (1 KB)  PDF (568 KB)  ( 22 ) 13 Clinical effect of Danshen Huayu Decoction combined with vacuum sealing drainage in the treatment of diabetic foot with choroid stasis type SHAN Hongtao LI Huagang▲ ZHOU Yuzhu Objective To explore the clinical effect of Danshen Huayu Decoction combined with vacuum sealing drainage (VSD) in the treatment of diabetic foot with choroid stasis type. Methods A total of 60 diabetic foot patients with choroid stasis type admitted to Department of Vascular Mammary Surgery，The First Affiliated Hospital of Anhui University of Traditional Chinese Medicine from October 2019 to June 2021 were selected as the research objects，and divided into the control group (30 cases) and the treatment group (30 cases) according to random number table method.The control group was treated with conventional debridement and VSD for 6 weeks，while the treatment group was given Danshen Huayu Decoction for 6 weeks on the basis of the control group. Treatment effect，symptom score，wound healing rate and related laboratory indicators (white blood cell [WBC]，C-reactive protein [CRP]，neutrophil granulocyte percent [NEU%]，fibrinogen [FIG]，D-dimer [D-D]) were compared between the two groups before and after 6 weeks of treatment. Results The total effective rate of the treatment group was higher than that of the control group，the difference was statistical significant (P＜0.05). Before treatment，there were no statistical significant differences of symptom scores (cold feeling，pain，lame distance) between the two groups (P＞0.05). After 6 weeks of treatment，the symptom scores (cold feeling，pain，lame distance) of two groups were lower than those before treatment in the group，and the difference was statistical significant (P ＜0.05). After 6 weeks of treatment，the symptom scores (cold feeling，pain，lame distance) of the treatment group was lower than those of the control group at the same period，the difference was statistical significant (P＜0.05). The wound healing rate of the treatment group was higher than that of the control group，the difference was statistical significant(P＜0.05). Before treatment，there were no statistical significant differences of the levels of CRP，WBC，NEU%，FIG，and D-D between the two groups (P＞0.05). After 6 weeks of treatment，the levels of CRP，WBC，NEU%，FIG，and D-D of two groups were lower than those before treatment in the group，and the difference was statistical significant (P＜0.05).After 6 weeks of treatment，the levels of CRP，WBC，NEU%，FIG，and D-D of the treatment group was lower than those of the control group at the same period，the difference was statistical significant (P＜0.05). Conclusion The clinical effect of Danshen Huayu Decoction combined with VSD in the treatment of diabetic foot with choroid stasis type is good，and it needs to be studied in depth. 2022 Vol. 29 (1): 13-17 [Abstract] ( 49 ) HTML (1 KB)  PDF (598 KB)  ( 22 ) 18 Mechanism study of Jiexiang Dingtong Capsules in the treatment of coronary heart disease based on network pharmacology CAO Baoguo1 LIU Huijuan2 WANG Xinshun1 WANG Heng3 MA Lin3 FAN Hongbo2 Objective To analyze the mechanism of Jiexiang Dingtong Capsules in the treatment of coronary heart disease by network pharmacology. Methods To screen the effective components and targets of Jiexiang Dingtong Capsules in traditional Chinese medicine systems pharmacology databaseand analysis platform (TCMSP)，the coronary heart disease gene targets were retrieved in OMIM database and GeneCards database，R language was used to map the common genes of Jiexiang Dingtong Capsules-coronary heart disease，Cytoscape software and STRING database were used to establish the traditional Chinese medicine regulatory and protein-protein interaction (PPI) network. To perform gene ontology (GO) function and Kyoto encyclopedia of genes and genomes (KEGG) pathway enrichment of common genes in R language by using bioconductor "DOSE" "clusterProfiler" and "pathview" packages. Results A total of 36 active components and 804 genes of Jiexiang Dingtong Capsules were screened，100 genes were common genes with coronary heart disease. PPI core network consists of 100 proteins and 390 edges. Key proteins involved mitogen-activated protein kinase 8 (MAPK8)，epidermal growth factor receptor (EGFR)，intedeukin-6 (IL-6)，estrogen receptor gene 1 (ESR1)and vascular endothelial growth factor (VEGFA). The results of GO enrichment analysis involved nuclear receptor activity，steroid hormone receptor activity，redox enzyme activity and estrogen receptor activity，etc. KEGG pathway were enriched with PI3K-Akt signaling pathway，fluid shear stress and atherosclerosis pathway，cell apoptosis pathway，tumor necrosis factor signaling pathway，etc. Conclusion There are multi-molecular and multi-gene targets and multipathway cooperative mechanisms in Jiexiang Dingtong Capsules in the treatment of coronary heart disease. It may affect steroid hormone receptor activity，oxidoreductase activity and estrogen receptor by regulating MAPK8 gene protein expression，and regulate PI3K-Akt signaling pathway，liquid shear stress and atherosclerosis pathway，cell apoptosis pathway，tumor necrosis factor signaling pathway to treat coronary heart disease. 2022 Vol. 29 (1): 18-22 [Abstract] ( 40 ) HTML (1 KB)  PDF (3226 KB)  ( 64 ) 23 Progress in the diagnosis and treatment of traumatic lacrimal cacaliculus rupture XIAO Fan JIANG Yanhua▲ Lacrimal canaliculus rupture is one of the commom injuries in clinical ophthalmology. It is usually complicated and requires timely surgical anastomosis. If it is not timely or improper，it will not only lead to permanent lacrimal overflow，but also cause eyelid deformity，which affects the appearance and physical and mental health of patients. The structure of lactear canaliculus is slender，the anatomical structure of tissue adjacent to inner canthus is fine，the operation space is narrow，and the technical level of surgical instruments and surgeons is high，so the surgical repair is difficult. The final goal of ophthalmologist′s treatment is to standardize the treatment process of patients with lacrimal canaliculus fracture，timely and effectively reset the anatomical structure of lacrimal duct，select appropriate artificial lacrimal duct and restore the drainage function of lacrimal duct. The success rate can be influenced by a number of factors，including the degree of trauma，the length of post-traumatic treatment，the type of surgery，and the material of the stent. Reviewing recent literature，the diagnosis and treatment of lacrimal canaliculus rupture has attracted much attention and made great progress. In this paper，the etiology，diagnosis，timing of treatment，location of the broken end，support selection，catheterization method，extubation time and prognosis of lacrimal canaliculus rupture are briefly reviewed. 2022 Vol. 29 (1): 23-26 [Abstract] ( 40 ) HTML (1 KB)  PDF (514 KB)  ( 25 ) 27 Progress in surgical treatment of varicose veins of lower extremities LIU Ming LIN Hongguo HE Yibin HUANG Yalan CAI Bingqin In modern clinical treatment of varicose veins of the lower extremities，surgical operation is still the main treatment method. With the advancement of surgical technology，surgical treatment methods include traditional surgery，intracavitary minimally invasive treatment and external atherectomy techniques，especially intracavitary minimally invasive techniques.Invasive treatments are progressing rapidly，including intracavitary laser，radiofrequency，microwave，electrocoagulation，foam sclerosing agent，mechanochemical ablation，but various surgical methods have advantages and disadvantages. This paper expounds the modern progress of several major surgical treatments methods，and holds that varicose veins of the lower extremities should be treated individually，and combined with multiple surgical methods，so as to achieve minimally invasive and effective treatment effect，but it still needs to be continuously improved in practice. 2022 Vol. 29 (1): 27-32 [Abstract] ( 38 ) HTML (1 KB)  PDF (482 KB)  ( 83 ) 33 Application effect of integrated multifunctional first aid kit in rapid response team LAN Guixiang1 LUO Qiulan2 FU Hongyan1 Objective To explore the application value of integrated multifunctional first aid kit in rapid response team(RRT). Methods A total of 21 critically ill patients in Ganzhou Municipal Hospital from June to November 2020 were selected as the control group，and 21 critically ill patients from December 2020 to may 2021 were selected as the study group. The study group and the control group were intervened by RRT，but the control group used the conventional method，and the study group used the integrated multifunctional first aid box. The preparation time，success rate，satisfaction degree and defect rate of emergency products were compared between the two groups. Results The preparation time of first-aid materials in the study group was shorter than that in the control group，and the success rate of rescue(95.24%) was higher than that in the control group (71.43%)，the differences were statistically significant (P＜0.05).There was no statistically significant difference in the satisfaction of the use of salvage products between the two groups(P＞0.05). The defect rate of rescue items in the study group was lower than that in the control group (19.05%)，and the difference was statistically significant (P＜0.05). Conclusion The integrated multifunctional first-aid kit has a high application value in RRT，which can shorten the preparation time of first-aid items，reduce the defect of rescuing items and drugs，and improve the success rate of rescue. 2022 Vol. 29 (1): 33-35 [Abstract] ( 47 ) HTML (1 KB)  PDF (592 KB)  ( 38 ) 36 Clinical effect of Glucocorticoid combined with Hydroxychloroquine in the treatment of systemic lupus erythematosus rash HU Shan Objective To analyze and evaluate the clinical effect of Glucocorticoid combined with Hydroxychloroquine in the treatment of systemic lupus erythematosus rash. Methods A total of 60 patients with systemic lupus erythematosus rash admitted to Shangrao City People's Hospital from January to December 2020 were selected as the research objects. The patients were all female. According to the order of admission，single and double numbers were divided into control group and study group，each with 30 cases. The control group was treated with a single Glucocorticoid，and the study group used Glucocorticoid combined with Hydroxychloroquine for treatment，the lupus erythematosus activity，inflammatory index erythrocyte sedimentation rate，C3 complement，total effective rate of rehabilitation，and occurrence of adverse reactions between the two groups were compared. Results The lupus erythematosus activity and inflammatory index erythrocyte sedimentation rate of the study group were lower than those of the control group，and the C3 complement level was higher than that of the control group，and the differences were significant (P＜0.05). The total effective rate of rehabilitation of the study group was higher than that of the control group，and the difference was significant (P＜0.05). The incidence of gastrointestinal reactions，mild white blood cell reduction，dizziness and discomfort in the study group were lower than those in the control group，and the differences were significant (P＜0.05). Conclusion The application of Glucocorticoids combined with Hydroxychloroquine in the treatment of systemic lupus erythematosus rash can effectively reduce the lupus erythematosus activity score and inflammatory index erythrocyte sedimentation rate，effectively increase the level of C3 complement，and can significantly improve the total effective rate of clinical treatment and reduce various adverse effects The occurrence of reaction，the clinical effect of this treatment method is significant，and it can be widely used in the clinical treatment of the disease. 2022 Vol. 29 (1): 36-38 [Abstract] ( 55 ) HTML (1 KB)  PDF (592 KB)  ( 48 ) 39 Evaluation of the efficacy of Recombinant Human Erythropoietin combined with Bortezomib and Dexamethasone in the treatment of multiple myeloma HUANG Zhaoping YANG Canhua▲ LIANG Rufang LYU Lina XIE Xingwen LIANG Shaowen HUANG Yuna CHEN Liuxian Objective To investigate the clinical effect of Recombinant Human Erythropoietin combined with Bortezomib and Dexamethasone in the treatment of elderly patients with multiple myeloma，in order to find a safe and efficient treatment plan for elderly patients with multiple myeloma. Methods A total of 80 elderly patients with multiple myeloma admitted to Wuming Hospital Affiliated to Guangxi Medical University from January 2016 to April 2021 were selected as the research subjects，and were divided into study group (40 cases) and control group (40 cases) according to random number table method. The control group was treated with Bortezomib combined with Dexamethasone，and the study group was treated with Recombinant Human Erythropoietin and Bortezomib combined with Dexamethasone. The total effective rate，laboratory indicators and the incidence of adverse reactions were compared between the two groups. Results The total effective rate of the study group was 85.0%，higher than that of the control group (72.5%)，and the difference was statistically significant (P＜0.05). After treatment，hemoglobin and albumin in the study group were higher than those in the control group，while creatinine，β2 microglobulin and serum calcium were lower than those in the control group，the differences were statistically significant (P＜0.05). There was no significant difference in the total incidence of adverse reactions between the two groups(P＞0.05).Conclusion The combination of Recombinant Human Erythropoietin，Bortezomib and Dexamethasone for multiple myeloma patients can achieve good curative effect，improve the blood index，and have good safety，which is worthy of clinical application and promotion. 2022 Vol. 29 (1): 39-42 [Abstract] ( 41 ) HTML (1 KB)  PDF (629 KB)  ( 214 ) 43 Application effect of bi-level non-invasive ventilation therapy in chronic obstructive pulmonary disease combined with obstructive sleep apnea hypopnea syndrome HUANG Xiaoxia LIU Hongbing Objective To investigate the application effect of bi-level non-invasive ventilation therapy in chronic obstructive pulmonary disease combined with obstructive sleep apnea hypopnea syndrome. Methods A total of 62 COPD patients with OSAHS who were admitted to Yunfu City People′s Hospital from June 2020 to June 2021 were selected as the research objects，and they were divided into the control group and the study group using the random number table method，with 31 cases in each group. The control group was treated with oxygen therapy，and the study group was treated with bi-level positive airway pressure. The arterial partial pressure of oxygen (PaO2)，arterial partial pressure of carbon dioxide (PaCO2)，oxygen saturation (SaO2)，apnea-hypopnea index (AHI)，and longest apnea time (LAT)，mean blood oxygen saturation at night (M-SaO2)，minimum blood oxygen saturation at night (L-SaO2) before treatment and 7 days after treatment，total clinical effective rate and adverse reactions were compared between the two groups. Results There was no significant difference in PaO2，PaCO2，SaO2，AHI，LAT，M-SaO2，L-SaO2 between the two groups before treatment (P＞0.05). After treatment，the PaO2，SaO2，M-SaO2，and L-SaO2 of the two groups were higher than those of the group before treatment，and the PaO2，SaO2，M-SaO2，and L-SaO2 of the study group were all higher than those of the control group，and the differences were statistically significant. (P＜0.05). After treatment，the PaCO2 and AHI of the two groups were lower than before the treatment，and the PaCO2 and AHI of the study group were lower than those of the control group，the differences were statistically significant (P＜0.05). After treatment，the LAT of the study group was shorter than that of this group before treatment and the control group，the differences were statistically significant (P＜0.05). The total clinical effective rate of the study group was higher than that of the control group，and the difference was statistically significant (P＜0.05). There were no obvious adverse reactions in the two groups. Conclusion The application effect of bi-level non-invasive ventilation in the treatment of COPD combined with OSAHS is relatively good. It can improve hypoxia，relieve hypercapnia，improve sleep quality，safety，and comprehensive application value. 2022 Vol. 29 (1): 43-46 [Abstract] ( 37 ) HTML (1 KB)  PDF (605 KB)  ( 37 ) 47 Application effect of nasal high flow humidified oxygen therapy on spontaneous pneumothorax YI Feifei ZHU Xiaorong LIU Chunyun Objective To investigate the effect of high-flow nasal cannula (HFNC)in spontaneous pneumothorax. Methods From May 2019 to October 2020，80 patients with spontaneous pneumothorax treated in the Fifth People′s Hospital of Ganzhou City were selected as the research objects and divided into the control group and the observation group according to the random number method，with 40 cases in each group. The control group received conventional oxygen delivery，and the observation group received HFNC high flow humidification oxygen delivery. The respiratory rate，heart rate，total compliance rate，time of symptom relief，length of hospital stay and incidence of adverse reactions were compared between the two groups before and after treatment. Results The respiratory rate and heart rate of the observation group 2 h and 2 d after treatment were lower than those of the control group，and the differences were statistically significant (P＜0.05). The total compliance rate of the observation group (97.50%) was higher than that of the control group(77.50%)，and the difference was statistically significant (P＜0.05). The time of symptom relief and length of hospital stay in observation group were shorter than those in control group，and the differences were statistically significant (P＜0.05). The total incidence of adverse reactions in observation group was lower than that in control group，and the difference was statistically significant (P＜0.05). Conclusion HFNC has a significant effect on patients with spontaneous pneumothorax during treatment and can improve patient compliance. 2022 Vol. 29 (1): 47-49 [Abstract] ( 47 ) HTML (1 KB)  PDF (616 KB)  ( 110 ) 50 Effect of non-invasive ventilation combined with pulmonary rehabilitation on immune function and inflammatory factors in patients with overlap syndrome ZHONG Yinghao CHEN Xiuzhen Objective To investigate the effect of non-invasive ventilation combined with pulmonary rehabilitation under bi-level positive airway pressure (BiPAP) mode on immune function of patients with chronic obstructive pulmonary disease (COPD) accompanied by obstructive sleep apnea hypopnea syndrome (OSAHS) overlap syndrome(OS). Methods A total of 100 patients with COPD-OSAHS OS admitted to People′s Hospital of Jiangmen City from April 2019 to June 2020 were selected as the research objects. All patients were divided into the treatment group and the control group by random number table method，with 50 patients in each group. Patients in the control group were given routine treatment of COPD and OSAHS，while patients in the treatment group were provided with non-invasive ventilation in BiPAP mode on the basis of the control group and pulmonary rehabilitation training. After 6 months of treatment，inflammatory indexes (interleukin-4 [IL-4]，interleukin-6 [IL-6]，tumor necrosis factor-α [TNF-α]) and immune indexes (mature T lymphocyte [CD3+]，induced/helper T cell [CD4+]，inhibitory/cytotoxic T cells [CD8+] and CD4+/CD8+) were compared between the two groups. Results Before treatment，there were no significant differences in the levels of IL-4，IL-6 and TNF-α between the two groups (P＞0.05). After treatment，the levels of IL-4，IL-6 and TNF-α in the treatment group were lower than those in the control group，the differences were statistically significant(P＜0.05). Before treatment，there were no statistically significant differences in CD3+，CD4+，CD8+，CD4+/CD8+ between the two groups (P＞0.05). After treatment，CD3+，CD4+，CD4+/CD8+in the treatment group were higher than those in the control group，while CD8+ was lower than that in the control group，the differences were statistically significant (P＜0.05). Conclusion Non-invasive ventilation combined with pulmonary rehabilitation in BiPAP mode can improve patients′ immune function and immune-related inflammatory factors，and reduce immune and inflammatory damage. 2022 Vol. 29 (1): 50-53 [Abstract] ( 48 ) HTML (1 KB)  PDF (607 KB)  ( 77 ) 54 Clinical effect of Snake Venom Hemagglutinase combined with Yunnan Baiyao in the treatment of non-varicose upper gastrointestinal bleeding ZHANG Xionghui CHEN Ruihong▲ Objective To investigate the clinical effect of Snake Venom Hemagglutinase combined with Yunnan Baiyao in the treatment of non-varicose upper gastrointestinal bleeding. Methods A total of 68 patients with non-varicose upper gastrointestinal bleeding admitted to Xiantao First People′s Hospital affiliated to Yangtze University from April 2020 to February 2021 were selected as the research subjects. The patients were divided into control group (34 cases)and treatment group (34 cases) by random number table method. The control group was treated with Yunnan Baiyao.The treatment group was treated with Snake Venom Hemagglutinase on the basis of the control group. Serum indicators(serum cortisol levels，high-sensitive C-reactive protein [hs-CRP])，total response rate and total incidence of complications were compared between the two groups. Results The total effective rate and serum indexes in the treatment group were better than those in the control group，and the differences were statistically significant (P＜0.05). There was no statistically significant difference in the total incidence of complications between the two groups (P＞0.05). Conclusion The combination of Yunnan Baiyao and Snake Venom Hemagglutinase in the treatment of non-varicose upper digestive tract bleeding has an ideal efficacy and low adverse reactions，which is worth reference in clinical use. 2022 Vol. 29 (1): 54-56 [Abstract] ( 53 ) HTML (1 KB)  PDF (591 KB)  ( 13 ) 57 Comparison between high flux hemodialysis and conventional hemodialysis in the treatment of chronic renal failure TAN Jing Objective To investigate the effect of high flux hemodialysis on chronic renal failure. Methods A total of 84 patients with chronic renal failure admitted to Iron Coal General Hospital of Liaoning Health Industry Group from March 2018 to December 2019 were selected as study subjects，and were divided into control group (42 cases) and study group (42 cases) according to the random number table method. The control group was treated with conventional hemodialysis，while the study group was treated with high flux hemodialysis. The efficacy，safety，and renal function level (serum creatinine [Scr]，cystatin C [Cys C]，blood urea nitrogen [BUN])，and the clearance effect of small molecular toxins (blood phosphorus，potassium，parathyroid hormone) were compared between the two groups. Results The total effective rate of treatment in the study group was higher than that in the control group，Scr，Cys C，BUN index levels were lower than those in the control group，adverse reaction rate was lower than that in the control group，the clearance rate of blood phosphorus，blood potassium，parathyroid hormone was higher than that in the control group，the differences were statistically significant (P＜0.05). Conclusion The efficacy and safety of high flux hemodialysis in patients with chronic renal failure are higher than routine hemodialysis，and it can effectively improve renal function and increase the clearance rate of small-molecule toxins. 2022 Vol. 29 (1): 57-59 [Abstract] ( 57 ) HTML (1 KB)  PDF (975 KB)  ( 26 ) 60 Clinical effect of Shensong Yangxin Capsules combined with Metoprolol in the treatment of ventricular premature beat in coronary heart disease HAO Lili LU Ruihua TANG Wenxin Objective To investigate the clinical effect of Shensong Yangxin Capsules combined with Metoprolol in the treatment of premature ventricular contractions in coronary heart disease. Methods A total of 60 patients with premature ventricular beats of coronary heart disease admitted to the Department of Cardiology，Heilongjiang College of Traditional Chinese Medicine From December 2019 to April 2021 were selected as the research subjects，and were divided into control group (30 cases) and treatment group (30 cases) according to random number table method. The control group was treated with conventional western medicine combined with Metoprolol，and the treatment group was treated with Shensong Yangxin Capsules on the basis of the control group. Traditional Chinese medicine (TCM)syndrome score，plasma N-terminal B-type natriuretic peptide (NT-proBNP)，angiotensin Ⅱ(Ang Ⅱ)，number of 24 h premature pulse and cardiac function indexes (left ventricular end systolic diameter [LVESD]，left ventricular end diastolic diameter [LVEDD]，left ventricular ejection fraction [LVEF]) were compared between the two groups. Results There was no significant difference in TCM syndrome score between the two groups before treatment (P＞0.05). After treatment，TCM syndrome scores of both groups were lower than before，and the treatment group was lower than the control group，the difference was statistically significant (P＜0.05). There was no significant difference in the levels of NT-proBNP and Ang Ⅱbetween two groups before treatment (P＞0.05). After treatment，the serum levels of NTproBNP and Ang Ⅱin both groups were lower than before，and the treatment group was lower than the control group，the differences were statistically significant (P＜0.05). There was no significant difference in the number of premature pulse 24 h before treatment between the two groups (P＞0.05). After treatment，the number of 24 h premature pulse in both groups was less than before，and the number of 24 h premature pulse in the treatment group was less than the control group，the difference was statistically significant (P ＜0.05). There was no significant difference in cardiac function indexes between the two groups before treatment (P＞0.05). After treatment，LVESD and LVEDD in the two groups were lower than before，and LVEF was higher than before，and LVESD and LVEDD in the treatment group were lower than the control group，and LVEF was higher than the control group，the differences were statistically significant(P＜0.05). Conclusion Shensong Yangxin Capsules combined with Metoprolol has obvious effect in the treatment of ventricular premature beat of coronary heart disease，which can improve the clinical symptoms of traditional Chinese medicine，improve NT proBNP and Ang Ⅱindexes，reduce the number of premature beats and improve cardiac function，which is worthy of promotion. 2022 Vol. 29 (1): 60-63 [Abstract] ( 47 ) HTML (1 KB)  PDF (547 KB)  ( 14 ) 64 Clinical application of Digoxin Injection in patients with heart failure and rapid atrial fibrillation WU Chunyan1 WANG Jianying2 Objective To observe the efficacy of Digoxin Injection and Cedi-lanid in the treatment of patients with heart failure and rapid atrial fibrillation on the basis of conventional treatment. Methods A total of 100 patients with heart failure and rapid atrial fibrillation in the Third Affiliated Hospital of South China University from January 2020 to March 2021were selected as the research objects，and they were divided into the experimental group and the control group according to random number table method，with 50 cases in each group. All patients received conventional antiheart failure treatment，the experimental group was given Digoxin injection，the control group was given Cedi-lanid Injection for treatment. The therapeutic effect of heart failure，ventricular rate，N-terminal B-type natriuretic peptide(NT-proBNP)，creatinine value and glomerular filtration rate were compared between the two groups before and after treatment. Results The total effective rate of the experimental group was higher than that of the control group，and the difference was statistically significant (P＜0.05). The overall comparison of ventricular rate at each time point after treatment between the two groups was statistically significant (P＜0.05). The ventricular rate in the experimental group was lower than that in the control group 3 and 6 h after treatment，the difference was statistically significant (P＜0.05).There was no significant difference in ventricular rate between the two groups at 9，12，15，18，21，24 h after treatment(P＞0.05). There were no significant differences in creatinine and glomerular filtration rate between the two groups before treatment (P＞0.05). After treatment，the NT-proBNP of the two groups were lower than before treatment，and the NT-proBNP of the experimental group was lower than the control group，the differences were statistically significant(P＜0.05). Conclusion Digoxin Injection can effectively improve the symptoms of patients with heart failure and atrial fibrillation，control the ventricular rate，and is well tolerated. It has great clinical value in the treatment of such patients.   2022 Vol. 29 (1): 64-67 [Abstract] ( 47 ) HTML (1 KB)  PDF (580 KB)  ( 45 ) 68 Clinical effect of Sacubitril Valsartan Sodium Tablets in the treatment of coronary heart disease complicated with chronic heart failure LIU Wei WEI Heng Objective To investigate the clinical efficacy of Sacubitril Valsartan Sodium Tablets in the treatment of coronary heart disease complicated with chronic heart failure (CHF) and the effect on the level of N-terminal pro-Btype natriuretic peptide (NT-proBNP) and cardiac function in patients. Methods A total of 126 patients with coronary heart disease and CHF admitted to Longkou People′s Hospital from January 2018 to January 2020 were selected as the research subjects. According to random number table method，they were divided into control group and observation group，63 cases in each group. The control group was treated with conventional treatment，and the observation group was treated with Sacubitril Valsartan Sodium Tablets on the basis of the control group，and continued to take medicine for 3 months. Clinical efficacy，NT-proBNP level，cardiac function indexes (left ventricular ejection fraction [LVEF]，stroke output [SV]，cardiac output [CO])，6-min walking distance，quality of life and the occurrence of adverse reactions were compared between the two groups. Results The total effective rate of observation group was higher than control group，the difference was statistically significant (P＜0.05). There was no significant difference in NT-proBNP level and cardiac function indexes between the two groups before treatment (P＞0.05). The level of NT-proBNP after treatment was lower than before treatment，while LVEF，SV and CO were higher than before treatment，the differences were statistically significant (P＜0.05). After treatment，the level of NT-proBNP in the observation group was lower than that in the control group，while LVEF，SV and CO were higher than those in the control group，the differences were statistically significant (P＜0.05). There were no significant differences in walking distance and Minnesota heart failure quality of life scale (MLHFQ) score before treatment between the two groups (P＞0.05). The walking distance 6 min after treatment was longer than before treatment，and the MLHFQ score was lower than before treatment，the differences were statistically significant (P＜0.05). The observation group had longer walking distance 6 min after treatment than the control group，and the MLHFQ score was lower than the control group，the differences were statistically significant (P＜0.05).There was no significant difference in the total incidence of adverse reactions between the two groups (P＞0.05). Conclusion Sacubitril Valsartan Sodium Tablets can enhance the therapeutic effect of coronary heart disease complicated with CHF，reduce the serum NT-proBNP level，accelerate the recovery of cardiac function，improve the quality of life of patients，and it is safe and reliable. 2022 Vol. 29 (1): 68-71 [Abstract] ( 46 ) HTML (1 KB)  PDF (549 KB)  ( 57 ) 72 Clinical effect of Amlodipine combined with Atorvastatin Calcium Tablets in the treatment of hypertension complicated with coronary heart disease BAI Sen Objective To explore the therapeutic effect of Amlodipine combined with Atorvastatin Calcium Tablets on hypertension complicated with coronary heart disease. Methods A total of 94 patients with hypertension complicated with coronary heart disease admitted to Fushun Hospital of Traditional Chinese Medicine from January to December 2019 were selected as the study subjects，and were divided into Telmisartan group (n=47) and Amlodipine group (n=47)according to random number table method. Telmisartan group was treated with Atorvastatin Calcium Tablets combined with Telmisartan，and Amlodipine group was treated with Atorvastatin Calcium Tablets combined with Amlodipine Besylate Tablets. Blood pressure，interleukin-2 (IL-2)，nitric oxide (NO)，endothelin (ET)，homocysteine (Hcy) and carotid intimedia thickness (IMT) were compared between two groups before and after treatment. Results There was no significant difference in blood pressure between the two groups before treatment (P＞0.05). After treatment，systolic blood pressure and diastolic blood pressure in both groups were lower than before，and systolic blood pressure and diastolic blood pressure in Amlodipine group were lower than those in Telmisartan group，the differences were statistically significant (P＜0.05). There was no significant difference in laboratory indexes between the two groups before treatment (P＞0.05). After treatment，the levels of IL-2，Hcy and ET in the two groups were lower than before treatment，and the level of NO was higher than before treatment. The levels of IL-2，Hcy and ET in the Amlodipine group were lower than that in the Telmisartan group，and the level of NO was higher than that in the temib group，the differences were statistically significant (P＜0.05). There was no significant difference in IMT between the two groups before treatment (P＞0.05). After treatment，IMT in the two groups was lower than before，and IMT in the Amlodipine group was lower than that in the Telmisartan group，the difference was statistically significant (P＜0.05). Conclusion Amlodipine Besylate combined with Atorvastatin Calcium Tablets in the treatment of hypertension and coronary heart disease has the function of balancing lumen contraction，promoting vascular damage repair，relieving vascular wall pressure，improving vascular smooth muscle function，and delaying the occurrence of inflammatory reactions，and inhibiting small vasospasm. 2022 Vol. 29 (1): 72-75 [Abstract] ( 54 ) HTML (1 KB)  PDF (570 KB)  ( 87 ) 76 Comparison of the efficacy of Ticagrelor and Clopidogrel in the treatment of acute ST-segment elevation myocardial infarction before percutaneous coronary intervention LI Peng XU Jianhui HU Wei Objective To compare the efficacy of ticagrelor and Clopidogrel in the treatment of acute ST-segment elevation myocardial infarction (STEMI) before percutaneous coronary intervention. Methods A total of 112 STEMI patients who received percutaneous coronary intervention (PCI) treatment in Xiaogan Hospital Affiliated to Wuhan University of Science and Technology from January 2015 to February 2019 were selected as research objects，and they were divided into Ticagrelor group and Clopidogrel group according to random number table method，with 56 cases in each group. Ticagrelor group was given Ticagrelor Tablets before PCI，and Clopidogrel group was given Clopidogrel Bisulfate Tablets before PCI. The changes of PCI indexes，myocardial enzymology indexes and N-terminal B-type brain natriuretic peptide precursor (NT-proBNP) level 24 h after operation were compared between the two groups. The incidence of adverse cardiovascular events in the two groups was calculated after 6 months follow-up. Results TIMI blood flow grading in Ticagrelor group was better than that in Clopidogrel group，the incidence of coronary chronic blood flow was lower than that in Clopidogrel group，and the differences were statistically significant (P＜0.05). Troponin I，phosphocatine kinase isoenzyme and NT-proBNP 24 h after surgery in the two groups were lower than those before treatment，and the troponin I，phosphocatine kinase isoenzyme and NT-proBNP in Ticagrelor group were lower than those in Clopidogrel group，the differences were statistically significant (P＜0.05). After 6 months of follow-up，the total incidence of adverse cardiovascular events in Ticagrelor group was lower than that in Clopidogrel group，and the difference was statistically significant (P＜0.05). Conclusion Compared with clopidogrel，the application of tigrelor before PCI can better restore coronary blood supply，reduce the incidence of chronic coronary blood flow，reduce myocardial injury，and have a clear effect of reducing the risk of adverse cardiovascular events. 2022 Vol. 29 (1): 76-79 [Abstract] ( 34 ) HTML (1 KB)  PDF (556 KB)  ( 36 ) 80 Comparison of the effects of Clopidogrel and Ticagrelor in the treatment of unstable angina pectoris YING Jun Objective To study the effects of Clopidogrel and Ticagrelor in the treatment of unstable angina pectoris.Methods A total of 120 patients with unstable angina pectoris (UA) treated in Liaoning Zhongzhi Shengjing Hospital of Geriatric from May 2020 to April 2021 were selected. According to random table method，they were randomly divided into control group and study group，with 60 cases in each group. All patients were treated with Aspirin，on this basis，the control group was treated with Clopidogrel and the study group was treated with Tigritol. The total effective rate，inflammatory response and blood lipid factors of the two groups were compared. Results The total effective rate of the study group was higher than that of the control group，the difference was statistically significant (P＜0.05). After treatment，homocysteine (Hcy) and interleukin-6 (IL-6) in the two groups were lower than those before treatment，and Hcy and IL-6 in the study group were lower than those in the control group，the differences were statistically significant (P＜0.05). After treatment，triglyceride (TG)，total cholesterol (TC) and low density lipoprotein cholesterol (LDL-C) in the two groups were lower than those before treatment，and TG，TC and LDL-C in the study group were lower than those in the control group，the differences were statistically significant (P＜0.05). Conclusion Ticagrelor can improve the total clinical effective rate of UA antithrombotic therapy by inhibiting inflammation and improving dyslipidemia. 2022 Vol. 29 (1): 80-83 [Abstract] ( 33 ) HTML (1 KB)  PDF (542 KB)  ( 14 ) 84 Related factors of carotid atheromatous plaque formation for acute cerebral infarction patients ZHANG Huiyuan LEI Jing LONG Min WANG Yingqi LIU Yan YANG Zhenhua Objective To explore the related factors of carotid atheromatous plaque formation for acute cerebral infarction patients. Methods A total of 130 patients with acute cerebral infarction admitted to Xinyu People′s Hospital of Jiangxi Province from September 2019 to April 2021 were selected as the study subjects. According on whether there were carotid plaque，they were divided into no carotid plaque group (30 cases) and carotid plaque group (100 cases).The main clinical characteristics of both groups were observed，and multivariate logistics regression analysis equations were used to analyze the factors affecting carotid atherosclerotic plaque formation in patients with acute cerebral infarction. Results Univariate analysis showed that systolic blood pressure，body mass index，low density lipaprotein cholosterol，and cystatin C (Cys C) were related factors affecting carotid atherosclerotic plaque formation in patients with acute cerebral infarction (P＜0.05). Compared between the sex，age，diastolic blood pressure，fasting blood glucose，total cholesterol，and triacylglycerol were not significantly significant (P＞0.05). Multivariate analysis showed that CysC is an independent risk factor for carotid atherosclerotic plaque formation in acute cerebral infarction (P＜0.05). Conclusion Serum CysC is involved in the formation of carotid atherosclerotic plaques，and elevated serum CysC levels are an independent risk factor for carotid atherosclerotic plaque formation in patients with acute cerebral infarction. 2022 Vol. 29 (1): 84-87 [Abstract] ( 37 ) HTML (1 KB)  PDF (641 KB)  ( 40 ) 88 Effect of Ziprasidone Injection on the agitation symptoms of adolescent with schizophrenia acute phase SONG Liu1 YU Suwei2 Objective To explore the effect of Ziprasidone Injection on the agitation symptoms of adolescent with schizophrenia (SCH) acute phase. Methods A total of 82 adolescent SCH patients with acute agitation symptoms admitted to the Fourth People′s Hospital of Yingkou from July 2019 to July 2020 were selected as research objects. According to random lottery，they were divided into study group and reference group，with 41 patients in each group. The patients in the reference group were treated with Haloperidol intramuscular injection，and patients in the study group were treated with Ziprasidone intramuscular injection. During the treatment，the excited component of positive and negative syndrome (PANSS-EC) scores and the total effective rate of the two groups at 6，12，24，48 and 72 hours after treatment were evaluated，and the adverse reactions of the two groups were compared to evaluate their safety. Results There was no significant difference in PANSS-EC scores before medication between the two groups (P＞0.05). The PANSS-EC scores of the two groups at 6，12，24，48 and 72 hours after medication were lower than those before medication，the differences were statistically significant (P＜0.05). The PANSS-EC scores of 6，12 hours after medication in the study group was lower than those in the reference group，the differences were statistically significant (P＜0.05). There was no significant difference in PANSS-EC scores between the two groups at 24，48 and 72 hours after treatment(P＞0.05).There were no significant difference in the total effective rate between the two groups (P＞0.05). The incidence of adverse reactions in the study group was lower than that in the reference group，the difference was statistically significant (P＜0.05).Conclusion In the treatment of the agitation symptoms of adolescent with SCH acute phase，Ziprasidone Injection can quickly control the symptoms and achieve the same effect as Haloperidol Injection，with better safety and good clinical application effect. 2022 Vol. 29 (1): 88-90 [Abstract] ( 41 ) HTML (1 KB)  PDF (655 KB)  ( 22 ) 91 Application effect of pain point injection combined with intermediate frequency electrotherapy in promoting functional rehabilitation of stroke patients MO Xialing YANG Guiyun XIAO Wenxiang MA Li YANG Hongying Objective To explore the application effect of pain point injection combined with intermediate frequency electrotherapy on promoting functional rehabilitation of stroke patients. Methods A total of 83 stroke patients who were admitted to the People′s Hospital of Yingde City，Guangdong Province from February 2019 to December 2020 were selected and divided into the control group (n=41) and the observation group (n=42) according to the random number table method. The control group were treated with intermediate frequency electrotherapy，and the observation group were added with pain point injection therapy on the basis of the control group，and both groups were intervened for 4 weeks. The pain score，limb motor function，ability of daily living and balance ability were compared between the two groups. Results There were no significant differences in pain scores，limb motor function，ability of daily living or balance ability scores between the two groups of patients before intervention (P＞0.05). The pain scores of the two groups after intervention were lower than those before intervention，and the scores of limb motor function，ability of daily living，and balance ability were higher than those before intervention，with statistical significances (P＜0.05). The pain score of the observation group after intervention was lower than that of the control group； after intervention，the upper limb motor function，lower limb motor function，ability of daily living，and balance ability scores of the observation group were higher than those of the control group，with statistical significances (P＜0.05). Conclusion The pain point injection combined with intermediate frequency electrotherapy is effective in patients with stroke，which can reduce the pain of patients，improve the motor function and balance function of the upper and lower limbs，and restore part of the ability of daily living. 2022 Vol. 29 (1): 91-94 [Abstract] ( 43 ) HTML (1 KB)  PDF (639 KB)  ( 54 ) 95 Clinical study of Sertraline combined with family therapy for adolescent depression disorder XIE Genying XIAO Yanqun HUANG Baihua Objective To explore the clinical effect of Sertraline combined with family therapy on adolescent patients with depression. Methods Eighty adolescent patients with depression who were admitted to the Third People′s Hospital of Ji′an City from January 2020 to October 2020 were selected as the research objects. They were divided into the joint group and the single group by numerical odd-even method，with 40 cases in each group. Patients in the combined group were treated with Sertraline+family therapy，and patients in the single group were treated with Sertraline. Summary coping style questionnaire (SCSQ) score and Hamilton depression scale (HAMD) score were compared between the two groups. Results Before treatment，there were no statistically significant differences in positive coping style score and negative coping style score between the combined group ([1.75±0.61]，[2.70±0.56] points) and the single group ([1.77±0.63]，[2.75±0.57] points) (P＞0.05). After treatment，the positive coping style score of the combined group ([2.25±0.45]points) was higher than that of the single group ([1.95±0.53] points)，and the negative coping style score ([1.85±0.61]points)was lower than that of the single group ([2.71±0.43] points)，the differences were statistically significant (P＜0.05).Before treatment，there was no statistically significant difference in HAMD score between the combined group ([25.49±2.29] points) and the single group ([25.53±2.32] points) (P＞0.05). After treatment，the HAMD score of the combined group ([8.52±1.11] points) was lower than that of the single group ([13.45±1.99] points)，and the difference was statistically significant (P＜0.05). Conclusion The combination of Sertraline and family therapy can significantly improve the positive coping style and negative coping style of adolescent depressive disorder patients，and improve depression. 2022 Vol. 29 (1): 95-97 [Abstract] ( 42 ) HTML (1 KB)  PDF (630 KB)  ( 50 ) 98 Clinical study of coagulation dysfunction in elderly type 2 diabetic patients with acute ischemic stroke QIU Zhiwei1 LI Caiming1 PENG Linping2 Objective To investigate the changes of coagulation function in elderly patients with type 2 diabetes(T2DM) with acute ischemic stroke (ACI). Methods From January 2018 to December 2020，60 elderly patients with T2DM and ACI who were admitted to the Huizhou First People′s Hospital were selected as group A，60 patients with pure T2DM in the same period were selected as group B，and 60 healthy patients in the same period were selected as group C. All candidates were tested for coagulation function indexes，and the coagulation function indexes of three groups were compared. In addition，patients in group A were grouped according to Adama classification，and the coagulation function indexes of patients with different infarct sizes were compared (prothrombin time [PT]，activated partial thromboplastin time [APTT]，fibrinogen [FIB] and DD dimer [DD]). Results PT and APTT of group A were lower than those of group B and group C，FIB and DD were higher than those of group B and group C，the differences were statistically significant (P＜0.05). PT and APTT of group B were lower than group C，and FIB and DD were higher than group C，the differences were statistically significant (P＜0.05)； PT and APTT in the large infarction group were lower than those in the small infarction group and lacunar infarction group，FIB and DD were higher than those in the small infarction group and lacunar infarction group，the differences were statistically significant (P＜0.05). The PT and APTT in the small infarction group were both lower than those in the lacunar infarction group，FIB and DD were higher than those in the lacunar infarction group，the differences were statistically significant (P＜0.05). Conclusion There is obvious coagulation disorder in elderly T2DM with ACI，and the abnormal coagulation index becomes more obvious with the increase of infarct size，which can be used as an important reference index to reflect the severity of the patient′s condition and evaluate the prognosis. 2022 Vol. 29 (1): 98-100 [Abstract] ( 47 ) HTML (1 KB)  PDF (644 KB)  ( 25 ) 101 Application effect of different doses of Dopamine agonists in the treatment of Parkinson′s disease AN Na Objective To investigate the application effect of different doses of Dopamine receptor agonist s in the treatment of Parkinson′s disease. Methods A total of 66 patients with Parkinson′s disease admitted to Anshan cancer hospital from September 2017 to September 2019 were selected as the research objects and divided into the control group and the observation group according to the dynamic random grouping method，with 33 cases in each group. The control group was treated with low-dose Dopamine receptor agonist (Pramipexole Hydrochloride Tablets) and the observation group was treated with high-dose Pramipexole Hydrochloride Tablets. The results of unified Parkinson′s disease rating scale (UPDRSDI) and the medical outcomes study 36-item short-form health survey (SF-36) scores were compared between the two groups. Results At the 4th，8th and 12th week of treatment，UPDRSDI scores of the observation group were lower than those of the control group，and the differences were statistically significant (P＜0.05). After treatment，the SF-36 score of the observation group was higher than that of the control group，the difference was statistically significant (P＜0.05). Conclusion Dopamine agonists have a significant effect in the treatment of Parkinson′s disease，and the effect varies with the dose. The use of large doses will improve the clinical treatment effect，so the clinical application should be evaluated based on the actual condition of patients. 2022 Vol. 29 (1): 101-103 [Abstract] ( 43 ) HTML (1 KB)  PDF (630 KB)  ( 25 ) 104 Clinical effect of step-by-step controlled decompression in the treatment of severe traumatic brain injury JIANG Zhiyuan Objective To investigate the clinical effect of step-by-step controlled decompression in the treatment of severe traumatic brain injury. Methods A total of 140 patients with severe traumatic brain injury admitted into the Affiliated Hospital of Xiangnan University from January 2019 to December 2020 were selected as the research subjects.They were divided into a control group and an observation group by random number table method，70 cases in each group. The patients in the control group were treated with craniotomy hematoma removal and bone flap decompression，and patients in the observation group were treated with step-by-step controlled decompression. The improvement of daily living ability，the total incidence of adverse reactions and the recovery of neurological function were compared between the two groups. Results There were no significant differences in intraoperative blood loss，postoperative hospital stay and operation time between the two groups (P＞0.05). Before treatment，there were no significant differences in the scores of independent living ability between the two groups (P＞0.05). The scores of eating，toilet，flat walking，bed and chair transfer and other independent living ability and total scores of patients in the observation group were higher than those in the control group after treatment，with statistically significant differences (P＜0.05). The total incidence of complications in the observation group was lower than that in the control group，the difference was statistically significant(P＜0.05). Before treatment，there were no significant differences in National Institutes of Health stroke scale (NIHSS)score and Barthel index of activities of daily living between the two groups (P＞0.05). NIHSS score of observation group was lower than that in the control group after treatment，the difference was statistically significant (P＜0.05). The Barthel index of the observation group was higher than that of the control group after treatment，the difference was statistically significant (P＜0.05). Conclusion The application of step-by-step controlled decompression in the treatment of severe traumatic brain injury can significantly improve the patients′ daily autonomous living ability after surgery，restore patients′ neurological function，and reduce the occurrence of adverse reactions. 2022 Vol. 29 (1): 104-107 [Abstract] ( 47 ) HTML (1 KB)  PDF (675 KB)  ( 66 ) 108 Analysis on the influencing factors of parental rearing style of adolescent depression ZHAO Hong Objective To explore and analyze the influencing factors of parental rearing style of adolescent depression.Methods A total of 100 adolescents with depression admitted to the Department of Psychological Adjustment of the Second People′s Hospital of Huizhou City from January 2018 to January 2020 were selected as the observation group，and 100 adolescents with healthy physical examination from the Department of Psychological Adjustment of the Second People′s Hospital of Huizhou City from January 2018 to January 2020 were selected as the control group. The age，gender，living environment，family income and other factors of the two groups were compared，and their parents′ parental rearing style was evaluated，and the influencing factors of parental parenting style of adolescent depression were analyzed. Results There were no statistically significant differences between the two groups in age，gender，living environment，family annual income and other general information (P＞0.05). There were no statistically significant differences between the two groups in parents′ age，educational level，marital relationship and other general information (P＞0.05).The results of univariate analysis showed that the scores of paternal preference of the subjects and paternal denial in the observation group were lower than those in the control group，the differences were statistically significant (P＜0.05).The scores of maternal punishment and severity，maternal excessive interference and maternal preference were lower than those in the control group，the differences were statistically significant(P＜0.05).The results of multiple linear regression analysis showed that paternal preference of the subjects score (β=0.564，SE=0.048，standard regression coefficient=0.466，t=8.957，P=0.0004)，paternal rejection score (β=0.879，SE=0.189，standard regression coefficient=0.267，t=5.998，P=0.0008)，maternal punishment and severity score (β=0.747，SE=0.057，standard regression coefficient=0.526，t=9.974，P=0.0002)，maternal excessive interference score (β=0.667，SE=0.042，standard regression coefficient=0.608，t=7.584，P=0.0003) and maternal preference score (β=0.555，SE=0.038，standard regression coefficient=0.559，t=7.978，P=0.0003) were risk factors for adolescent depression (P＜0.05). Conclusion The parents′ family education is the key factor that affects the depression of adolescents. It is suggested that the relevant measures should be implemented in an effective way to improve the negative emotions of depressed adolescents，so as to reduce the incidence rate of depression in adolescents. 2022 Vol. 29 (1): 108-111 [Abstract] ( 44 ) HTML (1 KB)  PDF (639 KB)  ( 106 ) 112 Correlation between cognitive function and hydrogen magnetic resonance spectrum in patients with mild cognitive impairment ZHANG Yun Objective To investigate the correlation between cognitive function and hydrogen proton magnetic resonance (1H-MRS) in patients with mild cognitive impairment (MCI). Methods Twenty patients with MCI who were hospitalized and outpatient in Shenyang Mental Health Center from January to December 2020 were selected as the MCI group，15 patients with Alzheimer′s disease (AD) who were hospitalized and outpatient during the same period were selected as the AD group，and twenty elderly volunteers with normal cognitive function were selected as the control group.The cognitive function and 1H-MRS of the subjects in the three groups were examined，and the mini-mental state examination (MMSE)，Montreal cognitive assessment scale (MOCA) scores and the ratio of N-acetyl aspartic acid (NAA)，choline containing compounds (Cho)，myo-inositol compound (MI) and creatine compound (Cr) in the bilateral hippocampus of the three groups were measured. The differences of NAA/Cr，MI/Cr and Cho/Cr among the groups were compared，and the correlation between MMSE and MOCA scores and the ratio of metabolites in each group was analyzed. Results The NAA/Cr of left hippocampus in MCI group was higher than that in AD group，and the NAA/Cr of left hippocampus in MCI group and AD group was lower than that in control group，the differences were statistically significant (P＜0.05). The MI/Cr of bilateral hippocampal in MCI group was lower than that of AD group，and the MI/Cr of bilateral hippocampal in MCI group and AD group was higher than that of control group，with statistical significances(P＜0.05). There was no significant difference in NAA/Cr of right hippocampus among the three groups (P＞0.05). There was no statistical significance in Cho/Cr of bilateral hippocampus among the three groups (P＞0.05). MMSE score was positively correlated with NAA/Cr in left hippocampus(r=0.618，P＜0.01). MMSE score was negatively correlated with MI/Cr in bilateral hippocampus (rleft=-0.552，Pleft＜0.01，rright=-0.462，Pright＜0.01). MoCA score was positively correlated with bilateral hippocampal NAA/Cr (rleft=0.669，Pleft＜0.01，rright=0.278，Pright＜0.05). MoCA score was negatively correlated with MI/Cr in bilateral hippocampus (rleft=-0.600，Pleft＜0.01，rright=-0.477，Pright＜0.01). MoCA score was positively correlated with Cho/Cr in the left hippocampus (r=0.322，P＜0.05). Conclusion MMSE and MOCA scores were correlated with the ratio of metabolites. 1H-MRS combined with cognitive function test was may helpful for the early diagnosis of MCI and AD. 2022 Vol. 29 (1): 112-115 [Abstract] ( 39 ) HTML (1 KB)  PDF (683 KB)  ( 22 ) 116 Effect of Metformin on serum heat shock protein 70 in patients with type 2 diabetes mellitus and clinical analysis FENG Ying1 WANG Zhongying2 ZHAO Shumin3 LIU Yan2 Objective To explore the effect of Metformin on serum heat shock protein 70 (HSP70) in patients with type 2 diabetes and its clinical analysis. Methods A total of 92 patients with type 2 diabetes who were hospitalized in the Department of Endocrinology，Affiliated Hospital of Heze Medical College from June 2018 to December 2020 were selected as the research subjects. According to the random number table method，they were divided into the control group and the experimental group，with 49 cases in each group. Patients in control group were given diet and exercise control，while patients in experimental group were given oral Metformin and diet and exercise control. If blood glucose control was not up to standard，insulin was given to reduce glucose. Body mass index (BMI)，fasting blood glucose (FPG)，glycosylated hemoglobin(HbA1c)and serum HSP70 levels were compared between the two groups before and after treatment.Results After treatment，the levels of FPG and HbA1c in the two groups were lower than those before treatment，and the differences were statistically significant (P＜0.05). After treatment，there was no statistically significant difference in BMI between the groups compared with before treatment(P＞0.05).After treatment，the serum HSP70 level of experimental group was lower than that before treatment，and the difference was statistically significant (P＜0.05). After treatment，there was no statistically significance difference in serum HSP70 level of control group compared with before treatment(P＞0.05).Conclusion Metformin can significantly reduce the serum HSP70 level in patients with type 2 diabetes. 2022 Vol. 29 (1): 116-119 [Abstract] ( 48 ) HTML (1 KB)  PDF (387 KB)  ( 38 ) 120 pplication effect of different doses of Atorvastatin in patients with diabetic cardiomyopathy Objective To explore the effect of different doses of Atorvastatin in patients with diabetic cardiomyopathy.Methods A total of 84 patients with diabetic cardiomyopathy admitted to the Foshan Hospital of Traditional Chinese Medicine from April 2020 to April 2021 were selected as the research objects，and they were divided into a conventional-dose group (n=42) and a high-dose group (n=42). The conventional-dose group was treated with 20 mg/d atorvastatin，and the high-dose group was treated with 40 mg/d Atorvastatin. The blood glucose indexes (fasting blood glucose [FBG]，2 h postprandial blood glucose [2 h PG]，glycosylated hemoglobin [HbA1c])，blood lipid (high density lipoprotein cholesterol [HDL-C]，total cholesterol [TC]，triglyceride [TG])，cardiac function indexes (ratio of early diastolic peak blood flow velocity to late diastolic peak blood flow velocity [E/a]，stroke volume [SV]，left ventricular ejection fraction [LVEF])，plasma brain natriuretic peptide (BNP)，serum matrix metalloproteinase-2 (MMP-2) and type Ⅲprocollagen amino terminal peptide (PⅢNP) before and after treatment，and the occurrence of adverse reactions during treatment were compared of the two groups. Results After treatment，the levels of FBG，2 h PG and HbA1c in the high-dose group were lower than those in the conventional-dose group，and the differences were statistically significant(P＜0.05). The HDL-C level of the high-dose group was higher than that of the conventional-dose group，and the levels of TC and TG were lower than those of the conventional-dose group，the differences were statistically significant (P＜0.05). The E/A，SV and LVEF of the high-dose group were higher than those of the conventional-dose group，and the differences were statistically significant (P＜0.05). The levels of BNP，MMP-2 and PIIINP in the high-dose group were lower than those in the conventional-dose group，and the differences were statistically significant(P＜0.05). There was no statistically significant difference in the total incidence of adverse reactions between the two groups (P＞0.05). Conclusion Compared with conventional doses，high-dose atorvastatin can better regulate blood glucose and blood lipid levels in patients with diabetic cardiomyopathy，further improve patients' cardiac function，promote ventricular remodeling，reduce myocardial fibrosis，and have good safety. 2022 Vol. 29 (1): 120-123 [Abstract] ( 47 ) HTML (1 KB)  PDF (381 KB)  ( 29 ) 124 Application value of dual energy subtraction and low-dose multi-slice spiral CT in the diagnosis of ureteral stones JING Juzhen LIAO Yusheng HUANG Mingyu Objective To explore the application value of dual energy subtraction (DES) and low-dose multi-slice spiral CT (MSCT) in the diagnosis of ureteral stones. Methods Sixty-two patients with suspected ureteral stones admitted to Zhongshan Hospital of Traditional Chinese Medicine from January 2020 to June 2021 were selected as study subjects. All 62 patients were examined for DES and low-dose MSCT to observe the diagnosis of ureteral stones with DES AND with low-dose MSCT.Using the final clinical diagnosis results as the gold standard，we compare the specificity，accuracy and sensitivity of DES with low dose MSCT diagnosis and compare the diagnostic detection rate of DES with low dose MSCT at different sites. Results The final clinical diagnosis showed that 49 of the 62 suspected ureteric stone patients were positive and 13 were negative.Among them，19 were ureteral stones in the lower segment，16 were middle ureteral stones，and 14 were upper ureteral stones. The accuracy and sensitivity of ureteral stones by DES were higher than low dose MSCT (P＜0.05)，the diagnosis of ureteral stones (P＞0.05) and the lower，middle and upper sections showed no difference (P＞0.05). Conclusion The high sensitivity and accuracy of ureteral stone diagnosis by DES is conducive to improving the detection rate of ureteral stones，reducing the risk of missed diagnosis and misdiagnosis，and then providing precise guidance for the diagnosis and treatment of patients，which can be used as a preferred method for the diagnosis of ureteral stones. 2022 Vol. 29 (1): 124-126 [Abstract] ( 41 ) HTML (1 KB)  PDF (478 KB)  ( 45 ) 127 Diagnostic value of digital X-ray dental film and CBCT for longitudinal root fracture CHEN Rulan PENG Limin Objective To explore the diagnostic value of digital X-ray dental film and CBCT for longitudinal root fracture. Methods Retroretrospective analysis of 45 patients suspected with longitudinal root fracture admitted to the Department of Medical Imaging，Affiliated People′s Hospital of Fujian University of Traditional Chinese Medicine from May 2018 to May 2018 to June 2019. All patients underwent digital X-ray dental film and CBCT examination respectively，and the pathological examination findings were used as the gold standard. The inspection results，sensitivity，specificity，accuracy，positive predictive values，and negative predictive values of the two test methods were compared.Results Pathological examination showed that 38 cases had longitudinal root fracture and 7 cases were non-dental root fracture. The sensitivity，specificity，accuracy，positive predictive value and negative predictive value of CBCT examination were higher than digital X-ray dental film examination，and the differences were statistical significant (P＜0.05).Conclusion CBCT was used to examine the longitudinal root fracture，with strong sensitivity，specificity and accuracy，and higher diagnostic value than digital X-ray dental film，which deserves extensive promotion and application. 2022 Vol. 29 (1): 127-129 [Abstract] ( 43 ) HTML (1 KB)  PDF (456 KB)  ( 162 ) 133 Application of ExacTrac system in the positioning of brain tumor radiotherapy LIN Zehuang PAN Zhenzhao QIU Minmin ZHONG Jiajian Objective To apply ExacTrac and OBI systems to perform image-guided radiotherapy for intracranial tumors，and cone beam CT (CBCT) to verify the results of the ExacTrac system moving bed correction，and evaluate the positioning accuracy of the ExacTrac system in brain tumor radiotherapy. Methods Twenty-eight patients with craniocerebral tumor radiotherapy in the First Affiliated Hospital of Sun Yat-sen University from January 2017 to January 2018 were selected as the research objects. First the three-dimensional laser system was used to position，and the ExacTrac system was used to take two cross X-ray images to obtain the three-dimensional translation error X (Left and right)，Y (in and out)，Z (up and down) and the corresponding rotation errors Rx，Ry，Rz. After the correction of the sixdimensional bed movement，the ExacTrac system was used to verify the corrected position and perform a CBCT scan on the accelerator. The setting errors of ExacTrac before and after correction，and CBCT were recorded and statistically analyzed. Results The translation errors in the X，Y，and Z directions of the ExacTrac system before correction were(-0.38±1.38) mm，(0.30±1.37) mm，and (-0.55±1.12) mm. The corrected error was (0.02±0.31) mm，(0.01±0.25) mm，and (-0.03±0.27) mm. The corresponding rotation errors were (-0.18±1.08)°，(0.35±1.60)°，(0.21±1.11)°，(0.06±0.19) )°，(0.01±0.23)°，and (-0.03±0.30)°，and they were compared before and after correction，with statistically significant differences (P＜0.05). CBCT verified that the corrected error of ExacTrac was (0.26±0.59) mm，(-0.42±0.55) mm，(0.22±0.53)mm，all of which did not exceed ±1 mm. Conclusion The ExacTrac system combined with the six-dimensional bed can significantly reduce the positioning error and improve the treatment accuracy. It is a reliable image guidance method in the radiotherapy of brain tumors. 2022 Vol. 29 (1): 133- [Abstract] ( 37 ) HTML (1 KB)  PDF (624 KB)  ( 30 ) 134 Effect of oral Saxagliptin combined with Metformin on the function of islet β cell function and bone metabolism in diabetic patients BAO Yaowen1 SHEN Yun2 Objective To investigate the effect of oral Saxagliptin combined with Metformin on the function of islet β cells and bone metabolism in diabetic patients. Methods A total of 72 diabetic patients admitted to Xinrui Hospital of Xiuwu District in the Wuxi City and the Fourth People′s Hospital of Taizhou from October 2018 to June 2020 were selected as the research subjects. They were divided into the control group and the observation group by random number table method，with 36 cases in each group. Patients in the control group were treated with Metformin，while patients in the observation group were treated with oral Saxagliptin on the basis of the control group. Islet β cell function and bone mineral density (BMD) were compared between the two groups. Results There were no statistically significant differences in early insulin secretion index (EISI)，modified beta cell index (MBCI)，pre-islet β cell (HOMA-β)，area under the curve of C-peptide (AUCcp)，area under the curve of insulin (AUCins) and area under the curve of blood glucose(AUCglu) between the two groups before treatment (P＞0.05). After treatment，the levels of EISI，MBCI，HOMA-β，AUCcp and AUCins in the two groups were higher than those before treatment，and the levels of EISI，MBCI，HOMA-β，AUCcp and AUCins in the observation group were higher than those in the control group，the differences were statistically significant (P＜0.05). After treatment，the levels of AUCglu in both groups were lower than those before treatment，and AUCglu level in the observation group was lower than that in the control group，the differences were statistically significant (P＜0.05). There was no statistically significant difference in BMD between the two groups before treatment (P＞0.05). After treatment，BMD in both groups were higher than those before treatment，and BMD in the observation group was higher than that in the control group，the differences were statistically significant (P＜0.05). Conclusion Oral Saxagliptin combined with Metformin has a positive and effective effect on the treatment of diabetes mellitus，which can improve pancreatic β cell function and bone metabolism. It has a certain clinical reference value and is worthy of popularization and application. 2022 Vol. 29 (1): 134-136 [Abstract] ( 44 ) HTML (1 KB)  PDF (425 KB)  ( 33 ) 137 Effect of pharmaceutical intervention + systematic prescription evaluation on rational use of Quinolones in patients with infectious diseases ZHANG Jun Objective To evaluate the influence of pharmaceutical intervention + systematic prescription evaluation on rational use of Quinolones in patients with infectious diseases. Methods A total of 684 patients with infectious diseases in Sihong Hospital from February 2020 to February 2021 were selected as the research subjects. All patients were treated with Quinolones prescriptions and divided into an intervention group and a general group by the random number table method. Patients in the intervention group were treated with pharmaceutical intervention + systematic prescription evaluation，while patients in the general group were treated with conventional prescription intervention. Unreasonable prescription，drug resistance and drug satisfaction were observed between the two groups. Results The contraindications，unreasonable usage and dosage，incompatibility and off-label drug use in the intervention group were 0.29%，2.34%，0.88% and 1.46%，respectively，which were lower than those in the general group (2.34%，7.89%，3.51%，5.85%)，with statistical significances (P＜0.05). The total incidence of irrational prescription in the intervention group(4.97%) was lower than that in the general group (19.59%)，the difference was statistically significant (P＜0.05). The drug resistance of Levofloxacin，Moxifloxacin，Gatifloxacin and Fonofloxacin in the intervention group were 8.19%，6.43%，5.26% and 6.14%，respectively，lower than 14.91%，13.74%，9.65% and 11.40% in the general group，with statistical significances (P＜0.05). The total medication satisfaction of the intervention group (97.66%) was higher than that of the general group (93.27%)，and the difference was statistically significant (P＜0.05). Conclusion Pharmaceutical intervention combined with systematic prescription evaluation can improve the rationality of prescription，promote Quinolones′ rational use，and have a positive effect on inhibiting Quinolones drug resistance. 2022 Vol. 29 (1): 137-140 [Abstract] ( 46 ) HTML (1 KB)  PDF (442 KB)  ( 73 ) 141 Clinical effect of Banxia Baizhu Tianma Decoction flexible modification in the treatment of essential hypertension with phlegm-dampness syndrome DAI Hongxu1 ZHAI Wenji2▲ XIANG Yuhua1 Objective To explore the clinical effect of Banxia Baizhu Tianma Decoction flexible modification in the treatment of essential hypertension with phlegm-dampness syndrome. Methods Ninety patients with essential hypertension diagnosed as phlegm-dampness syndrome treated in the Department of Cardiology Heilongjiang Academy of Chinese Medicine Sciences from June 2019 to March 2021 were selected as the research subjects，and they were divided into the treatment group and the control group by the random number table method，45 cases in each group. The patients in the control group were treated with oral Nifedipine Controlled-release Tablets，and in the treatment group，they were treated with Banxia Baizhu Tianma Decoction flexible modification on the basis of the control group. After 8 weeks of treatment，traditional Chinese medicine (TCM) syndrome score，TCM efficacy，systolic blood pressure，diastolic blood pressure，serum nitric oxide (NO)，endothelin-1 (ET-1) levels and incidence of adverse reactions were compared between the two groups. Results After treatment，the total effectiveness rate of the treatment group was 86.67%，which was higher than that in the control group accounting for 75.56%，the difference was statistically significant (P＜0.05). The TCM syndrome scores of patients in the two groups after treatment were lower than those before treatment，and the TCM syndrome scores of patients in the treatment group were lower than those in the control group after treatment，and the differences were statistically significant (P＜0.05). After treatment，the systolic and diastolic blood pressure levels of patients in the two groups were lower than those before treatment，and the systolic and diastolic blood pressure levels of the patients in the treatment group after treatment were lower than those in the control group，the differences were statistically significant (P＜0.05). After treatment，the NO levels of patients in the two groups were higher than those before treatment，and the ET-1 levels of patients in the two groups were lower than those before treatment，the NO level of the treatment group after treatment was higher than that in the control group，and the ET-1 level of the treatment group after treatment was lower than that in the control group，the differences were statistically significant (P＜0.05). During the treatment，no obvious adverse reactions occurred. Conclusion For patients with essential hypertension identified as phlegm-dampness syndrome，Banxia Baizhu Tianma Decoction flexible modification can improve blood pressure lowering，headache，dizziness and other TCM clinical symptoms，as well as vascular endothelial function. It is safe and effective，and is worthy of clinical promotion. 2022 Vol. 29 (1): 141-144 [Abstract] ( 44 ) HTML (1 KB)  PDF (446 KB)  ( 125 ) 145 Clinical effect of Qufeng-Zhitong Decoction in the treatment of acute gouty arthritis XIE Zhengquan ZHENG Lisha CAI Shaopeng JI Bing▲ Objective To explore the clinical effect of Qufeng-Zhitong Decoction in the treatment of acute gouty arthritis. Methods A total of 100 patients with acute gouty arthritis admitted to the Department of Endocrinology，Guangdong Clifford Hospital from June 2020 to January 2021 were selected as the research objects，and divided into the control group and the observation groups，with 50 cases in each group.The control group were treated by conventional Western medicine treatment. The observation group were treated by Qufeng-Zhitong Decoction based on the control group.The clinical effect，inflammatory factor(C reactive protein[CRP]，tumor necrosis factor alpha[TNF-α]，interleukin-1β [IL-1β]，interleukin-6 [IL-6]，interleukin-17 [IL-17])，erythrocyto sedimentation rate (ESR)，uric acid (UA) and Chinese medicine symptom score were observed. Results The total effective rate of the observation group was higher than that of the control group ，with statistically significant difference. Before treatment，there were no statistically significant differences in CRP，TNF-，IL-1，IL-6，IL-6 and IL-17 levels between the two groups (P＞0.05). After treatment，the levels of CRP，TNF-，IL-1，IL-6，IL-6 and IL-17 of the two groups were lower than those before the treatment in the group，and the differences were statistically significant (P＜0.05). After treatment，the levels of CRP，TNF-，IL-1，IL-6，and IL-17 of the observed group were lower than of the control group during the same period，and the differences were statistically significant (P＜0.05). Before treatment，there were no statistically significant differences in ESR，UA levels between the two groups (P＞0.05). After treatment，the levels of ESR，UA of the two groups were lower than those before the treatment in the group，and the differences were statistically significant (P＜0.05). After treatment，the levels of ESR，UA of the observed group were lower than of the control group during the same period，and the differences were statistically significant (P ＜0.05). Before treatment，there were no statistically significant differences in traditional Chinese medicine pathology score(joint redness and swelling，pain，mobility，dry skin，dark purple skin color) between the two groups (P＞0.05). After treatment，the traditional Chinese medicine pathology score (joint redness and swelling，pain，mobility，dry skin，dark purple skin color) of the two groups were lower than those before the treatment in the group，and the differences were statistically significant (P＜0.05). After treatment，the traditional Chinese medicine pathology score (joint redness and swelling，pain，mobility，dry skin，dark purple skin color) of the observed group were lower than of the control group during the same period，and the differences were statistically significant (P＜0.05). Conclusion It has prominent effect in patients with acute gouty arthritis treated by Qufeng Zhitong Decoction. It can improve the inflammatory factor，ESR，UA and Chinese medicine symptom score. It′s worth of clinical recommendations. 2022 Vol. 29 (1): 145-148 [Abstract] ( 43 ) HTML (1 KB)  PDF (423 KB)  ( 22 ) 149 Analysis on occupational health impact for female petrochemical workers ZHANG Bizhu CHEN Kengkeng CHEN Nianguang Objective To explore petrochemical female worker′s occupational health status and influence factors. Methods A total of 1085 female workers from a petrochemical company in Guangzhou from July to October 2017 were selected as the research subjects by using the judgment sampling method. According to GBZ 188-2014 Technical Specification for Occupational Health Monitoring，the occupational history，past history and self-conscious symptoms of the research objects were inquired，and their white blood cell count (WBC)，red blood cell count (RBC)，hemoglobin，platelet (PLT) and the serum alanine aminotransferase (ALT)，cervical cancer early screening two items，electrocardiogram and blood pressure were detected. Multivariate logistic regression analysis was used to analyze the influencing factors of occupational health. Results A total of 1085 questionnaires were distributed in this study，and 1000 valid questionnaires were collected，the effective questionnaire recovery rate was 92.17%. Among 1000 female workers in petrochemical company，251 subjects were in abnormal health status，accounted for 25.10%. The top three abnormal items were blood pressure (25.90%)，decreased WBC (14.74%) and decreased PLT (12.75%). The single factor results showed that the occupational health status of female workers in petrochemical company was not related to marriage，family income，education level，positive and negative life events (P＞0.05)，but related to age，bad living habits，overtime，shift，workload，mobility，occupational contact and length of service (P＜0.05). The results of multivariate logistic regression analysis showed that Age，bad living habits，overtime，shift，workload，mobility，occupational contact，length of service are the influencing factors of occupational health status of female workers in petrochemical company (P＜0.05). Conclusion The female workers in petrochemical companies have general physical conditions，long-term exposure to low-concentration gasoline and low-concentration ammonia may be associated with abnormal blood，PLT and liver function，and there are many influencing factors. Effective measures should be taken to improve the health of the female workers in petrochemical companies. 2022 Vol. 29 (1): 149-152 [Abstract] ( 46 ) HTML (1 KB)  PDF (595 KB)  ( 48 ) 153 Research on the relationship between locus of control and suicide idea of secondary vocational school students in the new period JIANG Linhui LU Biyan▲ LI Zhen LUO Qiuting Deng Guojin HUANG Yuanyuan ZHANG Wei Objective To understand the current situation of locus of control and suicidal ideation of secondary vocational school students in Dongguan in the new period and explore the relationship between them，so as to provide evidence for preventing suicide of secondary vocational school students. Methods In March，2020，A total of 1080 secondary vocational school students were selected from 3 secondary vocational schools in Dongguan by stratified cluster random sampling，and a network survey was conducted with locus of control scale (IPC) and self-rating idea of suicide scale (SIOSS). Results The prevalence rate of suicidal ideation was 3.9%，and there was no significant difference between boys (3.5%) and girls (4.0%) (P＞0.05). Pearson correlation analysis showed that internal control score was negatively correlated with suicidal ideation score (r=-0.167，P＜0.01)，while influential others score and opportunity score were positively correlated with suicidal ideation score (r=0.413，0.468，P＜0.01). The results of multivariate analysis showed that high score of internal control was the protective factor of suicidal ideation (β =-0.108，OR=0.897，95%CI=0.842-0.956)，and high score of influential others (β=0.079，OR=1.083，95%CI=1.019-1.151) and opportunity (β=0.080，OR=1.083，95%CI=1.014-1.157) were the risk factors of suicidal ideation (P＜0.05). Conclusion The detection rate of suicidal ideation of secondary vocational school students in Dongguan is relatively low in the new period，but it cannot be ignored. Locus of control is closely related to the level of suicidal ideation，which can effectively predict the level of suicidal ideation of secondary vocational school students. 2022 Vol. 29 (1): 153-157 [Abstract] ( 43 ) HTML (1 KB)  PDF (587 KB)  ( 9 ) 158 Current status and influencing factors of the return to work in young and middle-aged patients with spinal cord injury ZHANG Man1 ZHANG Shuqing2▲ Objective To explore the status and influencing factors of the return to work in young and middle-aged patients with spinal cord injury. Methods A total of 165 young and middle-aged patients with spinal cord injury discharged from Luoyang Orthopaedic-Traumatological Hospital of Henan Province (Henan Orthopaedic Hospital) from January 2018 to 2020 as the research objects. Counted the patients′ return to work and analyzed their relevant influencing factors. Results Fifty-three (32%) patients returned to work and one hundred-twelve (68%) are currently unemployed. The results of the univariate analysis showed that，cultural level (χ2=6.303，P=0.043)，damage site (χ2=10.788，P=0.005)，American Spinal Injury Association (ASIA) grade (χ2=52.177，P＜0.001)，mentality (χ2=53.646，P＜0.001)，return to work (χ2=130.143，P＜0.001)，Barthel score (t=6.764，P＜0.001) was a associated factor affecting the return to work in young and middle-aged spinal cord injury patients. Gender，age，marital status，method of payment，presence of work before injury，chronic history，postoperative time of both groups，and hospital stay days were compared between the two groups，the differences were not significantly significant (P＞0.05). The results of the multivariate analysis showed that the Barthel score (OR=0.940，95%CI=1.042-1.102，P＜0.001)，ASIA grade (OR=5.782，95%CI=1.109-39.159，P=0.037)，patient mentality (OR=6.336，95%CI=1.522-26.375，P=0.011)，the pathway of return to work (OR=56.503，95%CI=9.468-337.184，P＜0.001) were independent risk factors affecting young and middle-aged spinal cord injury patients. Conclusion During the long recovery process of young and middle-aged spinal cord injury patients，medical staff can help patients to return to work by improving their cognition and confidence in returning to work，and providing some ways to return to work. 2022 Vol. 29 (1): 158-161 [Abstract] ( 40 ) HTML (1 KB)  PDF (603 KB)  ( 50 ) 162 Investigation and analysis of anxiety and depression in parents of children with infantile hepatitis syndrome WANG Cheng1 LU Qingmei2 ▲ BAN Yicheng3 LIANG Liting3 CHEN Yuke3 LIANG Ying2 LUO Xiuzhuang3 NONG Meiyan4 Objectives To investigate the anxiety and depression of the parents of children with infantile hepatitis syndrome (IHS)，and to analyze the related factors，so as to provide the basis for the intervention measures. Methods From August 2018 to July 2020，a total of 72 parents of infants with infantile hepatitis syndrome were selected as the research subjects. Self-made general information questionnaire，self-rating anxiety scale (SAS) and self-rating depression scale (SDS) were used. Results The SAS and SDS scores of 72 IHS children parents were (60.52±5.67) point and(59.64±5.69) point，69 (95.80%) had different degrees of anxiety and 64 (88.90%) had different degrees of depression.Univariate analysis showed that there were statistically significant differences in SAS scores among parents of IHS children with different gender，education background，occupation，monthly family income，payment method and with or without complications (P＜0.05). The SDS scores of the parents of IHS children with different educational backgrounds，occupations，monthly family income，payment methods and without complications had statistical significance (P＜0.05). Multiple linear regression analysis indicated that low educational background was an independent risk factor for SAS score of IHS children′s parents (P ＜0.05)，while male caregivers and no complications were protective factors of SAS score (P＜0.05). Low income family，parents unemployed or farming were independent risk factors for SDS score (P＜0.05). Health insurance and no complications were protective factors for SDS score (P＜0.05). Conclusion Parents of children with IHS have higher levels of anxiety and depression，as well as greater psychological stress，especially those with lower educational level，poor family economic conditions and poor prognosis. Focusing on such people，the existing psychological problems of targeted，personalized psychological counseling，improve their anxiety and depression，improve their mental health level so as to reduce their psychological burden. 2022 Vol. 29 (1): 162-165 [Abstract] ( 40 ) HTML (1 KB)  PDF (580 KB)  ( 69 ) 167 Analysis of color Doppler ultrasound examination results of in-service staff in a university from 2016-2020 MA He Objective To analyze the results of color doppler ultrasound examination of in-service staff who participated in physical examination for 5 consecutive years in Shandong College of Traditional Chinese Medicine，to understand the health status of the faculty and staff，and to provide scientific basis for further prevention and health care and health education. Methods The data of color ultrasound examination of employees in the university from 2016 to 2020 was collected，and eliminated the abandoned or missed inspections，amounted to 1 553 cases. The detection rate of common diseases and the difference of disease detection rate among employees of different gender and age were analyzed. Results From 2016 to 2020，the abnormal detection rates of color doppler ultrasound were 90.64% (155/171)，90.40% (160/177)，93.50% (259/277)，95.93% (471/491) and 94.51% (413/437)，respectively. Fatty liver，liver cyst，kidney cyst，gallstone and gallbladder polyp were the top 5 common diseases detected by color doppler ultrasonography.The detection rates of renal cysts and thyroid nodules were higher in females than in males，and the detection rates of gallstones and carotid atherosclerosis were higher in males than in females，the differences were statistically significant(P＜0.05). There was no significant difference in the detection rates of other diseases in different genders (P＞0.05). The detection rate of renal cyst was the highest in the age group of ≤30 years old. The detection rate of gallbladder polyps was the highest in the age group of ＞30-40 years old. The detection rate of fatty liver and gallstone was the highest in the age group of ＞40-50 years old. The detection rate of carotid atherosclerosis and thyroid nodules was the highest in the age group of ＞50-60 years old (P＜0.05). Conclusion The health condition of the staff in the university is not optimistic. Relevant departments should pay more attention and take health promotion interventions to prevent and reduce the incidence of diseases. So as to improve the health status and the health quality of the staff. 2022 Vol. 29 (1): 167-169 [Abstract] ( 48 ) HTML (1 KB)  PDF (943 KB)  ( 29 ) 170 Observation on the clinical effect of preventing phlebitis in elderly patients based on PDCA circulation method JIANG Zhili1 CAI Feiyan1 LIN Xingzhen2 Objective To explore the effect of PDCA circulation method in elderly patients. Methods From March 2021 to May 2021，100 elderly patients who underwent intravenous indwelling needle puncture treated admitted to Nanchang Hongdu Hospital of Traditional Chinese Medicine were selected as the research objects. According to the random number table，they were divided into the control group (50 cases) and the improved group ( 50 cases). The control group adopts routine management，and the improved group implemented PDCA cycle management on this basis.The occurrence of phlebitis between the two groups was compared，the pain degree of limb puncture before and 3 days after the intervention，and the patients′satisfaction with nursing were investigated. Results The incidence of phlebitis in the improved group was 4.00%，which was lower than 18.00% in the control group. The difference was statistically significant (P＜0.05). The pain degree of the improved group after intervention was lighter than that of the control group，the nursing satisfaction score of the improved group was higher than that of the control group，and the difference was statistically significant (P＜0.05). Conclusion The PDCA circulation method can reduce the incidence of phlebitis in elderly patients，reduce the pain of patients，and improve patient satisfaction. 2022 Vol. 29 (1): 170-173 [Abstract] ( 48 ) HTML (1 KB)  PDF (638 KB)  ( 49 ) 174 Effect of phased health cognitive nursing in the nursing of lymphoma patients XIA Yanling SUN Shuyan TAN Huifang LONG Fen YI Qi XU Lizhen Objective To explore the application effect of phased health cognitive nursing in the nursing of lymphoma patients. Methods From January to December 2020，a total of 86 cases of lymphoma patients in Yichun People′s Hospital were selected as the research object. The patients were divided into control group (43 cases) and observation group(43 cases) by random number table method. The control group was treated with conventional nursing methods，and the observation group was treated with conventional nursing combined with phased health cognition nursing methods. Rehabilitation effect (length of stay，self-rating anxiety scale [SAS] score)，mental resilience (the connor-davidson resilience scale [CD-RISC]) and quality of life ([GQOL-74] score) were compared between the two groups. Results The hospitalization time of the observation group was shorter than that of the control group，the difference was statistically significant (P＜0.05). There was no statistical significance in the SAS scores between the two groups before nursing (P＞0.05).After nursing，the SAS scores of the two groups were lower than before，and the observation group was lower than the control group，the differences were statistically significant (P＜0.05). Before nursing，there was no significant difference in CD-RISC score between the two groups (P＞0.05). After nursing，the CD-RISC score in the two groups was higher than before，and the CD-RISC score in the observation group was higher than that in the control group，the differences were statistically significant (P＜0.05). There was no significant difference in GQOL-74 scores between the two groups before nursing (P＞0.05). After nursing，the GQOL-74 score of the two groups was higher than before，and the GQOL-74 score of the observation group was higher than the control group，the differences were statistically significant (P＜0.05). Conclusion Staged health cognitive nursing for patients with lymphoma has good nursing effect and is worth popularizing. 2022 Vol. 29 (1): 174-177 [Abstract] ( 41 ) HTML (1 KB)  PDF (627 KB)  ( 39 ) 178 Application of risk nursing management model in the perioperative period of minimally invasive surgery for chronic subdural hematoma GUO Ting Objective To explore the application effect of risk nursing management model in the perioperative period of minimally invasive surgery for chronic subdural hematoma (CSDH). Methods A total of 60 patients with CSDH treated in Shangrao Third People′s Hospital from were selected January 2019 to June 2020 were selected，and were divided into the observation group and the control group according to the random number table method，30 cases in each group.The control group was given routine nursing，and the observation group adopted risk nursing management model on the basis of the control group. The differences in postoperative recovery indicators and incidence rates of risk events and complications were compared between the two groups of patients at 3 weeks after surgery. Results At 3 weeks after surgery，the tubulization time，hospital stay and incidence rates of risk events and total incidence rate of complications in observation group were shorter or lower than those in control group，the differences were statistically significant (P＜0.05). Conclusion Risk nursing management model in the perioperative period of CSDH minimally invasive surgery can reduce the probabilities of risk events and complications，and improve the recovery efficiency. 2022 Vol. 29 (1): 178-180 [Abstract] ( 46 ) HTML (1 KB)  PDF (620 KB)  ( 33 ) 181 Effect of Shunqi Tongfu Decoction enema in the treatment of Yin deficiency caused by drug-induced constipation in patients with cancer pain HUANG Xiaomei1 ZHU Zhifang2 ZHANG Lingzhen1 LIU Jing2 YI Yanfei2 LIU Yong2 Objective To explore the clinical application value of Shunqi Tongfu Decoction enema in the treatment of Yin deficiency caused by drug-induced constipation in patients with cancer pain. Methods A total of 80 patients with Yin deficiency，constipation and cancer pain were diagnosed in Ganzhou Cancer Hospital from January to December 2019 were selected. They were divided into the control group and the experimental group according to random number table method，40 cases in each group. The control group was treated with oral Lactulose，and the experimental group was treated with oral Lactulose combined with Shunqi Tongfu Decoction enema. The short-term efficacy and satisfaction of the two groups at 2 courses after treatment were observed. The scores of constipation symptom severity scale(Wexner) and quality of life scale (PAC-QOL) in the two groups were observed before and after treatment，and the total incidence rate of adverse reactions was recorded. Results The score of Wexner scale in the experimental group at 2 courses after treatment was lower than that in the control group，the scores of each dimension of PAC-QOL in the experimental group at 2 courses after treatment were lower than those in the control group，and the differences were statistically significant (P＜0.05). The clinical total effective rate of the experimental group was higher than that of the control group，and the difference was statistically significant (P＜0.05). There were no adverse reactions in the two groups.The total satisfaction of the experimental group was better than that of the control group，the difference was statistically significant (P＜0.05). Conclusion The Yin deficiency caused by drug-induced constipation in patients with cancer pain were treated by Shunqi Tongfu Decoction enema，and the curative effect was good，which could improve their quality of life，improve treatment satisfaction，and ensure the smooth progress of cancer pain treatment. 2022 Vol. 29 (1): 181-184 [Abstract] ( 36 ) HTML (1 KB)  PDF (667 KB)  ( 27 ) 185 Application effect of comprehensive nursing intervention on mechanical thrombectomy combined with large dose Atorvastatin in the treatment of acute cerebral infarction with large vessel occlusion HUANG Shaoman1 LIN Yuwei2 LUO Shiwei2 HAN Qiaolin2 LIN Kaisheng2▲ Objective To explore the application effect of comprehensive nursing intervention on mechanical thrombectomy combined with high-dose Atorvastatin in the treatment of acute cerebral infarction with large vessel occlusion（LVO）. Methods From June 2018 to December 2020，80 patients with LVO cerebral infarction in Jieyang People′s Hospital were selected as the research objects，and they were divided into the control group (40 cases） and the observation group (40 cases) according to the nursing mode. The control group was given routine nursing and the observation group was given comprehensive nursing. Nursing satisfaction，emotional status，neurological function，blood lipid level and prognosis were compared between the two groups. Results The nursing total satisfaction of the observation group was higher than that of the control group，the difference was statistically significant (P＜0.05). Before nursing，there was no significant difference in the score of emotional status between the two groups (P＞0.05). After nursing，the score of emotional status in the observation group was lower than that in the control group，and the difference was statistically significant (P＜0.05）. There was no significant difference in neurological function between the two groups before nursing(P＞0.05)，but the neurological function score of the observation group was lower than that of the control group after nursing，the differences were statistically significant (P＜0.05). The blood lipid level of the observation group was lower than that of the control group，the total incidence of adverse prognosis in the observation group was lower than that in the control group，and the differences were statistically significant (P＜0.05). Conclusion The implementation of comprehensive nursing intervention for patients with LVO cerebral infarction treated by mechanical embolectomy combined with high-dose Atorvastatin can effectively strengthen the treatment effect of patients，improve the prognosis，and alleviate the anxiety and depression of patients，which is worthy of clinical application. 2022 Vol. 29 (1): 185-188 [Abstract] ( 32 ) HTML (1 KB)  PDF (628 KB)  ( 19 ) 189 Effects of nursing intervention based on information-motivation-behavior skill model in high-risk primiparas of parenting sense of competence ZHANG Nan Objective To explore the influence of nursing intervention based on information- motivation-behavior skill model in high-risk primiparas of parenting sense of competence. Methods A total of 70 high-risk primiparas who were treated in Women and Children Health Care Center in Dalian and planned to give birth were selected as the study objects. The non-synchronous control study method was as followed，the control group was selected from October 2019 to January 2020，and the intervention group was selected from February to May 2020，35 high-risk primiparas in each group. High -risk primiparas were received routine nursing guidance in the control group，including parenting knowledge and improve their compliance of obstetric exams. On this basis，the high-risk primiparas in the intervention group were provided with parenting knowledge and skills，namely information-motivation-behavior skill model nursing intervention，once every two weeks from 28 weeks of gestation to full term. Also，we made a questionnaire survey on high-risk primiparas，before intervention，before leaving hospital，42 days after postpartum and three months after postpartum. Results Before leaving hospital，42 days after postpartum and three months after postpartum the results of the intervention group comparison of feelings of competence of parenting showed that the total points and the points of all dimension in the intervention group were higher than those in the control group (P＜0.05). Comparison of parenting competence before leaving hospital，42 days after postpartum and three months after postpartum，time factors and interference factors and intervention factors (P＜0.05)，the total scores and scores of each dimension of the feeling of parenting competence before leaving hospital，42 days after postpartum and three months after postpartum were higher in both groups than before intervention. The total score and each dimension score of inpatient satisfaction in the intervention group were higher than those in control group (P＜0.05). Conclusion Information-motivation-behavior nursing intervention could improve high-risk primiparas feelings of competence of treating babies，and provide highrisk primiparas with better quality nursing serves，to improve the satisfaction of high-risk primiparas in communication，system，environment，service and other aspects. 2022 Vol. 29 (1): 189-192 [Abstract] ( 41 ) HTML (1 KB)  PDF (1129 KB)  ( 82 ) 193 Impact of continuous rehabilitation care on postoperative functional recovery and activities of daily living in patients with complex hand trauma LUO Yan WU Hansheng ZENG Haiqian Objective To investigate the effects of continuous rehabilitation care on postoperative functional recovery and activities of daily living in patients with complex hand trauma. Methods Eighty patients with complicated hand trauma admitted to Guangdong Work Injury Rehabilitation Hospital，between February 2017 and December 2018 were selected as study subjects and divided into control group (n=40) and study (n=40) group according to the random number table method. The control group adopted conventional nursing methods，and the research group added continuous rehabilitation nursing methods on the basis of conventional nursing methods. Ability of daily living(ADL) and complications (muscle atrophy，scar contracture，joint stiffness，tendon rupture or adhesion). Results The total incidence of complications in the study group was lower than that in the control group，and the difference was statistically significant(P＜0.05). There was no significant difference in hand function and ADL before nursing between the two groups (P＞0.05). The hand function and ADL of the two groups of patients after nursing were better than those of this group before nursing，and the differences were statistically significant (P＜0.05). The hand function and ADL of the study group after nursing were better than those of the control group，and the differences were statistically significant (P＜0.05). Conclusion Patients with complicated hand trauma receive continuous rehabilitation care，which may reduce complications and benefit the recovery of hand function of patients after surgery，and it is worth promoting the application. 2022 Vol. 29 (1): 193-196 [Abstract] ( 40 ) HTML (1 KB)  PDF (671 KB)  ( 225 )

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