| [1] |
Khan MAB，Hashim MJ，King JK，et al.Epidemiology of Type 2 Diabetes-Global Burden of Disease and Forecasted Trends[J].J Epidemiol Glob Health，2020，10（1）：107-111.
|
| [2] |
Tans R，Verschuren L，Wessels HJCT，et al.The future of protein biomarker research in type 2 diabetes mellitus[J].Expert Rev Proteomics，2019，16（2）：105-115.
|
| [3] |
Mulyani WRW，Sanjiwani MID，Prabawa IPY，et al.Chaperone-Based Therapeutic Target Innovation：Heat Shock Protein 70 （HSP70） for Type 2 Diabetes Mellitus[J].Diabetes Metab Syndr Obes，2020，13：559-568.
|
| [4] |
Alemi H，Khaloo P，Rabizadeh S，et al.Association of extracellular heat shock protein 70 and insulin resistance in type 2 diabetes；independent of obesity and C-reactive protein[J].Cell Stress Chaperones，2019，24（1）：69-75.
|
| [5] |
中华医学会糖尿病学分会.中国2 型糖尿病防治指南（2017年版）[J].中华糖尿病杂志，2018，10（1）：4-67.
|
| [6] |
Burkart V，Germaschewski L，Schloot NC，et al.Deficient heat shock protein 70 response to stress in leukocytes at onset of type 1 diabetes[J].Biochem Biophys Res Commun，2008，369（2）：421-425.
|
| [7] |
Garamvlgyi Z，Prohászka Z，Rigó J Jr，et al.Increased circulat-ing heat shock protein 70 （HSPA1A）levels in gestational diabetes mellitus：a pilot study[J].Cell Stress Chaperones，2015，20（4）：575-581.
|
| [8] |
Krause M，Heck TG，Bittencourt A，et al.T he chaperone balance hypothesis: the importance of the extracellular to intracellular HSP70 ratio to inflammation-driven type 2 diabetes，the effect of exercise，and the implications for clinical management[J].Mediators Inflamm，2015，2015：249 205.
|
| [9] |
Krause M.The regulatory roles of NADPH oxidase intraand extra-cellular HSP70 in pancreatic islet function，dysfunction and diabetes[J].Clin Sci，2015，128（11）：789-803.
|
| [10] |
Goettems-Fiorin PB，Grochanke BS，Baldissera FG，et al.Fine particulate matter potentiates type 2 diabetes development in high-fat diet-treated mice：stress response and extracellular to intracellular HSP70 ratio analysis[J].J Physiol Biochem，2016，72（4）：643-656.
|
| [11] |
Kaneto H，Kimura T，Obata A，et al.Multifaceted Mechanisms of Action of Metformin Which Have Been Unraveled One after Another in the Long History[J].Int J Mol Sci，2021，22（5）：2596.
|
| [12] |
Gong Y，Wang C，Jiang Y，et al.Metformin Inhibits Tumor Metastasis through Suppressing Hsp90α Secretion in an AMPKα1-PKCγ Dependent Manner[J].Cells，2020，9（1）：144.
|
| [13] |
Chen TW，Liang YN，Feng D，et al.Metformin inhibits proliferation and promotes apoptosis of HER2 positive breast cancer cells by downregulating HSP90[J].J BUON，2013，18（1）：51-56.
|
| [14] |
Crouse AB，Grimes T，Li P，et al.Metformin Use Is Associated With Reduced Mortality in a Diverse Population With COVID-19 and Diabetes[J].Front Endocrinol （Lausanne），2021，11：600 439.
|
| [15] |
Davis BJ，Xie Z，Viollet B，et al.Activation of the AMPactivated kinase by antidiabetes drug metformin stimulates nitric oxide synthesis in vivo by promoting the association of heat shock protein 90 and endothelial nitric oxide synthase[J].Diabetes，2006，55（2）：496-505.
|
