轻度认知功能障碍患者认知功能与氢质子磁共振波谱的相关性

Abstract
Figure/Table
References (18)
Related Citation (15)

Download: PDF (683 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To investigate the correlation between cognitive function and hydrogen proton magnetic resonance (1H-MRS) in patients with mild cognitive impairment (MCI). Methods Twenty patients with MCI who were hospitalized and outpatient in Shenyang Mental Health Center from January to December 2020 were selected as the MCI group，15 patients with Alzheimer′s disease (AD) who were hospitalized and outpatient during the same period were selected as the AD group，and twenty elderly volunteers with normal cognitive function were selected as the control group.The cognitive function and 1H-MRS of the subjects in the three groups were examined，and the mini-mental state examination (MMSE)，Montreal cognitive assessment scale (MOCA) scores and the ratio of N-acetyl aspartic acid (NAA)，choline containing compounds (Cho)，myo-inositol compound (MI) and creatine compound (Cr) in the bilateral hippocampus of the three groups were measured. The differences of NAA/Cr，MI/Cr and Cho/Cr among the groups were compared，and the correlation between MMSE and MOCA scores and the ratio of metabolites in each group was analyzed. Results The NAA/Cr of left hippocampus in MCI group was higher than that in AD group，and the NAA/Cr of left hippocampus in MCI group and AD group was lower than that in control group，the differences were statistically significant (P＜0.05). The MI/Cr of bilateral hippocampal in MCI group was lower than that of AD group，and the MI/Cr of bilateral hippocampal in MCI group and AD group was higher than that of control group，with statistical significances(P＜0.05). There was no significant difference in NAA/Cr of right hippocampus among the three groups (P＞0.05). There was no statistical significance in Cho/Cr of bilateral hippocampus among the three groups (P＞0.05). MMSE score was positively correlated with NAA/Cr in left hippocampus(r=0.618，P＜0.01). MMSE score was negatively correlated with MI/Cr in bilateral hippocampus (rleft=-0.552，Pleft＜0.01，rright=-0.462，Pright＜0.01). MoCA score was positively correlated with bilateral hippocampal NAA/Cr (rleft=0.669，Pleft＜0.01，rright=0.278，Pright＜0.05). MoCA score was negatively correlated with MI/Cr in bilateral hippocampus (rleft=-0.600，Pleft＜0.01，rright=-0.477，Pright＜0.01). MoCA score was positively correlated with Cho/Cr in the left hippocampus (r=0.322，P＜0.05). Conclusion MMSE and MOCA scores were correlated with the ratio of metabolites. 1H-MRS combined with cognitive function test was may helpful for the early diagnosis of MCI and AD.

Key words： Mild cognitive impairment； Alzheimer&prime s disease； 1H-magnetic resonance spectroscopy； Neuropsychological test

Received: 22 June 2021

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	ZHANG Yun

Cite this article:

ZHANG Yun. Correlation between cognitive function and hydrogen magnetic resonance spectrum in patients with mild cognitive impairment[J]. 中国当代医药, 2022, 29(1): 112-115.

URL:

http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2022/V29/I1/112

[2]	Morley JE.An overview of cognitive impairment[J].Clin Geriatr Med，2018，34（4）：505-513.
[6]	Petersen RC.Mild cognitive impairment as a diagnostic entity[J].Inter Med，2004，256（3）：183-194.
[1]	Brookmeyer R，Johnson E，Ziegler-Graham K，et al.Forecasting the global burden of Alzheimer′s disease[J].Alzheimers Dement，2007，3（3）：186-191.
[3]	Modrego PJ，Fayed N，Sarasa M.Magnetic resonance spectroscopy in the prediction of early conversion from amnestic mild cognitive impairment to dementia：a prospective cohort study[J].BMJ Open，2011，23（1）：7.
[4]	中国痴呆与认知障碍诊治指南写作组，中国医师协会神经内科医师分会认知障碍疾病专业委员会．2018 中国痴呆与认知障碍治指南（五）：轻度认知障碍的诊断与治疗[J].中华医学杂志，2018，98（17）：1294-1301.
[5]	中国痴呆与认知障碍诊治指南写作组，中国医师协会神经内科医师分会认知障碍疾病专业委员会.2018 中国痴呆与认知障碍治指南（一）：痴呆及其分类诊断标准[J].中华医学杂志，2018，98（13）：965-970.
[7]	Busse A，Hensel A，Gühne Ueurology，et al.Mild cognitive impairment：long-term course of four clinical subtypes[J].Neurology，2006，67（12）：2176-2185.
[8]	Khomenko YG，Kataeva GV，Bogdan AA，et al.Cerebral metabolism in patients with cognitive disorders：a combined MRS and PET study[J].Zh Nevrol Psikhiatr Im S S Korsakova，2019，119（1）：51-58.
[9]	袁文昭，韦懿宸，麦威，等.遗忘型轻度认知功能障碍患者海马代谢物含量与认知功能的相关性分析[J].广西医科大学报，2018，35（5）：657-661.
[10]	Wolf H，Grunwald M，Kruggel F，et al.Hippocampal volume discriminates between normal cognition：questionable and mild dementia in the elderly[J].Neurobiol Aging，2001，22（2）：177-186.
[11]	Antarci K.Magnetic resonance spectroscopy in common dementias[J].Neuroimaging Clin N Am，2013，23（3）：393-406.
[12]	Tiwari V，Patel AB.Pyruvate carboxylase and pentose phosphate fluxes are reduced in ABPP-PS1 mouse model of Alzheimer′s disease：a 13C NMR study[J].Alzheimer Dis Assoc Disord，2014，41（2）：387-399.
[13]	Siger M，Schuff N，Zhu X，et al.Regional myo inositol concentration in mild cognitive impairment using1H magnetic resonance spectroscopic imaging[J].Alzheimer Dis Assoc Disord，2009，23（1）：57-62.
[14]	Chao LL，Mueller SG，Buckley ST，et al.Evidence of neurodegeneration in brains of older adults who do not yet fulfill MCI criteria[J].Neurobiol Aging，2010，31（3）：368-377.
[15]	Kantarci K，Weigand SD，Petersen RC，et al.Longitudinal1HMRSchangesinmildcognitiveimpairmentandAlzheimer′s disease[J].Neurobiol Aging，2007，28（9）：1330-1339.
[16]	DongY，Lee WY，Basri NA，et al.The Monteral Cognitive Assessment is superior to the Mini-Mental State Examination in detecting patients at higher risk of dementia[J].Int Psychogeriatr，2012，24（11）：1749-1755.
[17]	陈杰，肖叶玉，吴美联，等.双额叶脑代谢物浓度改变与轻度认知功能障碍的磁共振波谱量化研究[J].中华核医学与分子影像杂志，2021，41（2）：93-97.
[18]	郑加平，路伟，王珊珊，等.MCI 和AD 患者记忆损害与左侧额叶及海马代谢产物的相关性[J].山东医药，2015，55（18）：55-57.