半夏白术天麻汤化裁治疗痰湿壅盛证原发性高血压的临床效果

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Abstract Objective To explore the clinical effect of Banxia Baizhu Tianma Decoction flexible modification in the treatment of essential hypertension with phlegm-dampness syndrome. Methods Ninety patients with essential hypertension diagnosed as phlegm-dampness syndrome treated in the Department of Cardiology Heilongjiang Academy of Chinese Medicine Sciences from June 2019 to March 2021 were selected as the research subjects，and they were divided into the treatment group and the control group by the random number table method，45 cases in each group. The patients in the control group were treated with oral Nifedipine Controlled-release Tablets，and in the treatment group，they were treated with Banxia Baizhu Tianma Decoction flexible modification on the basis of the control group. After 8 weeks of treatment，traditional Chinese medicine (TCM) syndrome score，TCM efficacy，systolic blood pressure，diastolic blood pressure，serum nitric oxide (NO)，endothelin-1 (ET-1) levels and incidence of adverse reactions were compared between the two groups. Results After treatment，the total effectiveness rate of the treatment group was 86.67%，which was higher than that in the control group accounting for 75.56%，the difference was statistically significant (P＜0.05). The TCM syndrome scores of patients in the two groups after treatment were lower than those before treatment，and the TCM syndrome scores of patients in the treatment group were lower than those in the control group after treatment，and the differences were statistically significant (P＜0.05). After treatment，the systolic and diastolic blood pressure levels of patients in the two groups were lower than those before treatment，and the systolic and diastolic blood pressure levels of the patients in the treatment group after treatment were lower than those in the control group，the differences were statistically significant (P＜0.05). After treatment，the NO levels of patients in the two groups were higher than those before treatment，and the ET-1 levels of patients in the two groups were lower than those before treatment，the NO level of the treatment group after treatment was higher than that in the control group，and the ET-1 level of the treatment group after treatment was lower than that in the control group，the differences were statistically significant (P＜0.05). During the treatment，no obvious adverse reactions occurred. Conclusion For patients with essential hypertension identified as phlegm-dampness syndrome，Banxia Baizhu Tianma Decoction flexible modification can improve blood pressure lowering，headache，dizziness and other TCM clinical symptoms，as well as vascular endothelial function. It is safe and effective，and is worthy of clinical promotion.

Key words： Banxia Baizhu Tianma Decoction Essential hypertension Phlegm-dampness syndrome Clinical effect Security

Received: 22 July 2021

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