Objective To study the influence of comprehensive rehabilitation nursing on wound healing，complications and quality of life in patients with deep burn.Methods A total of 74 patients with deep burns who admitted to our hospital from February 2016 to February 2018 were enrolled in the study.They were divided into study group and control group according to random number table method，37 patients in each group.Patients in the study group were provided with comprehensive rehabilitation nursing，while the control group，they were treated with routine care.The wound healing，complications and quality of life were compared between the two groups.Results After the comprehensive rehabilitation nursing，the wound healing time of the study group was shorter than that of the control group with significant difference （P＜0.05）.The total incidence of complications of the study group was lower compared with that of the control group with statistical difference （P＜0.05）.The patients in the study group had higher quality of life score than those of the control group with statistical significance （P＜0.05）.Conclusion For patients with deep burns，comprehensive rehabilitation care can speed up the healing of wound，greatly reduce the incidence of complications and improve the quality of life，which is worthy of promotion in clinical practice.