Objective To investigate the effect of high quality nursing in patients with chronic schizophrenia.Methods A total of 60 patients with chronic schizophrenia admitted to our hospital from October 2014 to October 2017 were enrolled.According to different nursing methods，they were divided into observation group and control group，30 cases in each group.In the control group，routine nursing was used，while in the observation group，on the basis of routine nursing，high quality nursing was added.The mental recovery，psychological condition and total nuring satisfaction were compared between the two groups.Results The brief psychiatric rating scale （BPRS）and nurses′observation scale for inpatient evaluation（NOSIE）scores of the two groups after nursing were both lower than those before nursing.The selfrating depression scale （SDS）and self-rating anxiety scale （SAS）scores were significantly lower than those before the nursing with statistical significance（P＜0.05）.The BPRS and NOSIE scores of the observation group after nursing were both lower than compared with those in the control group.The SDS and SAS scores after nursing were both lower than those of the control group with statistical significance（P＜0.05）.Conclusion Application of high quality nursing in patients with chronic schizophrenia can significantly improve the mental indicators of patients as well as the SDS and SAS scores，and increase the total nursing satisfaction compared with routine nursing，which is worthy of promotion in clinical practice.