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Quick Search     Adv Search 2022 Vol. 29, No. 15 Published: 2022-05-28   5 Optimization of extraction process of baicalin from Jinbei Huatan Granules by orthogonal test YANG Xiaori;JIANG Huizhen;ZHANG Li;WANG Jundong;GU Jiahui;DU Lijun;SUN Lifeng;SUN Qiya Objective To explore the optimal extraction process of baicalin from Jinbei Huatan Granules by orthogonal test. Methods Water extraction technology was used to optimize the optimal water extraction process, with the extraction rate of baicalin from Scutellaria baicalensis in the prescription of Jinbei Huatan Granules and the rate of prescription ointment as indexes, and the effect of extraction multiple, extraction times and extraction time on the indexes were investigated by orthogonal experimental design. Verification tests were carried out. Results The optimal water extraction process of baicalin from Jinbei Huatan Granules was to add 10 times of water and extract for 3 times,each time for 2 hours.The results showed that the average transfer rate of baicalin was 78.96% and RSD was 4.035% in the optimal process.The average extraction rate was 47.48% and RSD was 1.11%, which proved that the extraction process was stable and feasible. Conclusion The optimized extraction process is reasonable and feasible, with high extraction rate and good reproducibility. It can provide technical reference for the development of modern preparation of Jinbei Huatan Granules. 2022 Vol. 29 (15): 5-8转13 [Abstract] ( 36 ) HTML (1 KB)  PDF (884 KB)  ( 44 ) 9 Protective mechanism of Baicalin on the myocardium of diabetic rats XU Qiuling;ZHENG Xuezhi;WANG Wenting;ZHANG Xudong;GUO Ran Objective To study the protective mechanism of Baicalin on the myocardium of diabetic rats. Methods Twenty-four male SD rats were randomly divided into the control group (6 rats), the Baicalin control group (6 rats), the model group (6 rats) and the treatment group (6 rats). Experimental diabetes models were established by tail vein injection of 45 mg/kg streptozotocin in the model group and the treatment group. The Baicalin control group and the treatment group were given intraperitoneal injection of 15 μmol/(L·kg·d) Baicalin liquid, while in the control group and the model group, the intraperitoneal injection of normal saline was used. The four groups were fed with normal diet. After 8 weeks, blood glucose, mitochondrial structure, myocardial mitochondrial damage ratio, activity of respiratory chain complexes Ⅰ, Ⅱ, Ⅲ, Ⅳ, ND1 mRNA and ND1 protein expression were compared among the four groups. Results The blood glucose of the model group was higher than that of the control group, and the blood glucose of the treatment group was lower than that of the model group, the differences were statistically significant (P＜0.05). The percentage of damaged mitochondria in the model group was higher than that in the control group, and the percentage of damaged mitochondria in the treatment group was lower than that in the model group, and the differences were statistically significant (P＜0.05). The activities of myocardial mitochondrial respiratory chain complexes Ⅰ, Ⅱ, Ⅲ, Ⅳin the model group were lower than those in the control group, the activities of myocardial mitochondrial respiratory chain complexes Ⅰ,Ⅱ, Ⅲ, Ⅳin the treatment group were higher than those in the model group, the differences were statistically significant (P＜0.05). The ND1 mRNA and ND1 protein in the model group were lower than those in the control group, and the ND1 mRNA and ND1 protein in the treatment group were higher than those in the model group, the differences were statistically significant (P＜0.05). Conclusion The activity of mitochondrial respiratory chain complex and the expression of ND1 gene and protein of mitochondrial respiratory chain complex Ⅰsubunit were decreased in diabetic rats. Baicalin may play a protective role in diabetic myocardium by increasing the activity of mitochondrial respiratory chain complex and enhancing the expression of ND1 gene and protein of complex Ⅰsubunit. 2022 Vol. 29 (15): 9-13 [Abstract] ( 35 ) HTML (1 KB)  PDF (797 KB)  ( 28 ) 14 Analysis of psychological elasticity level and its correlation with quality of life and psychological state in patients with inflammatory bowel disease HUANG Aolan;YIN Xinhong;TAN Xiuzhu;YAO Keru Objective To investigate the level of mental resilience, quality of life and psychological status of patients with inflammatory bowel disease and analyze their correlation. Methods A total of 200 patients with inflammatory bowel disease treated in the First Affiliated Hospital of University of South China, the Second Affiliated Hospital of University of South China and Nanhua Hospital of University of South China from January to November 2021 were selected as the study subjects by convenience sampling method. General data questionnaire, mental resilience scale, anxiety selfrating scale, depression self-rating scale, inflammatory bowel disease quality of life questionnaire were used to investigate. The factors affecting resilience and their correlation with quality of life, anxiety and depression were analyzed.Results The scores of resiliency behavior, quality of life, anxiety and depression in inflammatory bowel disease patients were (84.11±30.002), (120.9±18.997), (49.825±8.58) and (47.44±6.92) points. Multiple linear regression analysis showed that in demographic data, gender, working status, living style, complications, educational level, family monthly income, medical expense payment method and family relationship were independent factors that affected mental resilience score (P＜0.05). Resilience was positively correlated with quality of life (r=0.769), and negatively correlated with anxiety (r=-0.527) and depression (r=-0.390) (P＜0.05). Conclusion Patients with inflammatory bowel disease have a low level of mental resilience, a low quality of life, and a high incidence of anxiety and depression. Mental resilience is related to quality of life, anxiety and depression. When medical staff in the clinical intervention, but based on the general situation to develop personalized clinical treatment and nursing measures, through targeted psychological intervention, improve the level of patients psychological elasticity, to further understand its impact on patients′ quality of life, anxiety and depression, and improve patient quality of life, ease the anxiety and depression. 2022 Vol. 29 (15): 14-18 [Abstract] ( 31 ) HTML (1 KB)  PDF (593 KB)  ( 25 ) 19 Predictive value of serum ferritin, 25- hydroxyvitamin D and high sensitivity C reactive protein in early pregnancy for gestational diabetes mellitus JIN Lianhua;MA Ziwen; SHEN Shuangyu;ZHANG Baoren; MAO Meili Objective To determine the application value of serum ferritin (SF), 25- hydroxyvitamin D[25- (OH) D] and high sensitivity C reactive protein (hs-CRP) in the prediction of gestational diabetes mellitus (GDM) in early pregnancy.Methods The retrospective selection of 573 pregnant women who registered for the first visit in the obstetric clinic of Pudong New Area Maternal and Child Health hospital from January 2020 to December 2020 were selected as the research objects. All of them were tested for normal fasting blood glucose in the first trimester (12-16 weeks of gestation),and then passed the oral 75 g glucose tolerance test at 24-28 weeks of gestation. Parturients diagnosed with GDM were divided into observation group (273 cases), and non-GDM parturients were as the control group (300 cases). The levels of SF, 25-(OH)D, and hs-CRP in the two groups of parturients at 12-16 weeks of gestation were analyzed, and the effects of SF, 25-(OH)D, and hs-CRP on GDM were analyzed with logistic regression, and ROC curves were drawn. The predictive value of SF, 25-(OH)D, and hs-CRP was analyzed. Results There was no significant difference in fasting blood glucose (FPG) between the two groups (P＞0.05). SF and hs-CRP in the observation group were higher than those in the control group, while 25-(OH) D was lower than those in the control group, the differences were statistically significant (P＜0.05). Logistic regression analysis showed that SF and hs-CRP were risk factors for GDM (P＜0.05, OR＞1),and 25-(OH) D was protective factor (P＜0.05, OR＜1). The areas under the ROC curve of SF, 25-(OH) D and hs-CRP at 12-16 weeks of gestation were 0.730, 0.716 and 0.788, respectively, the sensitivity was 66.3%, 71.4% and 72.5%,and the specificity was 69.0%, 64.0% and 77.3%, respectively. The area under the curve of combined diagnosis of the SF, 25-(OH) D and hs-CRP was 0.818, the sensitivity was 71.1% and the specificity was 79.7%. Conclusion The combined detection of serum ferritin, 25-(OH) D and hs-CRP in early pregnancy has a certain predictive value for the occurrence of GDM, and has a certain positive significance for early detection, early prevention, glucose control for patients with GDM, and improvement of pregnancy outcome. 2022 Vol. 29 (15): 19-22 [Abstract] ( 30 ) HTML (1 KB)  PDF (641 KB)  ( 19 ) 23 Expression level and diagnostic value of squamous cell carcinoma antigen and interleukin-38 in peripheral blood of patients with cervical cancer QIN Caifeng;YANG Jinqiong;XU Xuezhen Objective To investigate the expression level and diagnostic value of squamous cell carcinoma antigen(SCC) and interleukin-38 (IL-38) in peripheral blood of patients with cervical cancer. Methods A total of 52 cases of cervical cancer patients admitted to Gaozhou People′s Hospital in February 2019 to May 2021 were selected as the study group, 50 patients with uterine intraepithelial neoplasia admitted to Gaozhou People′s Hospital in the same period were selected as the neoplastic group, and 50 normal healthy women examined in Gaozhou People′s Hospital in the same period were selected as the control group. The expression levels of SCC and IL-38 in the three groups were detected and compared on admission. The expression levels of IL-38 and SCC in patients with different pathological factors were compared. After treatment, IL-38 and SCC of patients in the study group were detected and compared with the results on admission. Finally, the diagnostic efficacy of each index was evaluated by receiver operating characteristic (ROC) curve. Results The expression levels of IL-38 and SCC in the study group were higher than those in the neoplastic group and control group, the differences were statistically significant (P＜0.05). The two indexes in the neoplastic group were also higher than those in the control group, the differences were statistically significant (P＜0.05). After treatment, IL-38 and SCC expression levels of the study group were lower than those before treatment, the differences were statistically significant (P＜0.05). IL-38, SCC expression levels of Ⅲ/Ⅳstage were higher than those of theⅠ/Ⅱstage, IL-38 expression level of high degree of differentiation was higher than that of low, medium degree of differentiation, IL-38 expression level of medium degree of differentiation was higher than that of low degree of differentiation, the differences were statistically significant (P＜0.05). ROC curve showed that the area under curve (AUC) of serum IL-38 and SCC in the diagnosis of cervical cancer was 0.729 and 0.748, while the AUC of combined diagnosis was 0.826, with a sensitivity of 82.32% and specificity of 76.37%, both higher than single indexes. Conclusion SCC and IL-38 are related to the incidence and progression of cervical cancer. The combination of SCC and IL-38 as diagnostic indicators can improve the accuracy of cervical cancer diagnosis, which has great clinical guiding significance and diagnostic value for the disease, and is worthy of popularization and application. 2022 Vol. 29 (15): 23-26 [Abstract] ( 34 ) HTML (1 KB)  PDF (594 KB)  ( 22 ) 27 Research progress on loneliness and its influencing factors of widowed elderly in rural areas HE Yuefang;YU Mengting The aging of our country is becoming more and more serious. The loneliness of the elderly is a significant psychological problem that arises with the aging, and it is an important factor affecting the quality of life of the elderly.Through reading domestic and foreign literature, it is found that the loneliness of the widowed elderly in rural areas is more significant than that of the widowed elderly in urban and community areas. There are two main factors affecting the loneliness of the widowed elderly in rural areas: First, demographic factors, including age, gender, education level,whether to remarry, family economic status, children′s company, etc. The second is social factors, which mainly refer to social support. According to the influencing factors, corresponding measures are proposed from the personal, family, and social aspects. It is hoped that more people will pay attention to the mental health of the widowed elderly in rural areas,and provide reference for the promotion of the mental health of the widowed elderly in rural areas. 2022 Vol. 29 (15): 27-30 [Abstract] ( 38 ) HTML (1 KB)  PDF (470 KB)  ( 134 ) 31 Research progress of diagnosis and treatment of neonate with different subtypes of respiratory syncytial virus HUANG Xiaoxi;DU Kun Respiratory syncytial virus (RSV) is the common cause of respiratory infections in neonate. The clinical manifestations are lack of the specificity, therefore it can be ignored to cause severe infection. Moreover, the neonatal immune system is not fully developed, the severity of disease is more serious than older children and more prone to explosive infection. It has been classified into two genotypes of A and B (RSV-A and RSV-B) based on the difference response of RSV G protein with monoclonal antibodies and G protein genes, and multiple infections can be repeated because the neutralizing antibodies of different subtypes of RSV do not provide effective pritection in different genotypes.There are many reports at home and abroad on whether the disease severity is different between the two subtypes, but the conclusions are different. To investigate the relationship between the different genotypes and disease, this paper reviews the epidemiology, clinical manifestations, treatment and prevention of neonatal respiratory syncytial virus, aiming to provide a scientific basis for vaccine development and the formulation of clinical specific prevention. 2022 Vol. 29 (15): 31-35 [Abstract] ( 46 ) HTML (1 KB)  PDF (513 KB)  ( 124 ) 36 Research progress of the relationship between nonalcoholic fatty liver disease and components of metabolic syndrome WANG Yuanyuan;JIANG Jianping Non-alcoholic fatty liver disease (NAFLD) can be divided into primary and secondary categories. The former is related to insulin resistance and genetic susceptibility, while the latter is caused by some special reasons. Excessive weight gain and overweight caused by excess nutrition, obesity, diabetes, hyperlipidemia and other metabolic syndrome-related fatty liver are secondary NAFLD category. With the trend of globalization of metabolic syndrome,NAFLD has become an important cause of chronic liver disease in developed countries such as Europe and the United States and rich areas of China. In addition to directly leading to decompensated cirrhosis, hepatocellular carcinoma and liver transplantation recurrence, NAFLD can also affect the progression of other chronic liver diseases and be involved in the pathogenesis of type 2 diabetes and atherosclerosis. Malignant tumors associated with metabolic syndrome, arteriosclerotic cardiovascular and cerebrovascular diseases, and cirrhosis are important factors affecting the quality of life and life expectancy of NAFLD patients. Therefore, NAFLD is a new challenge in the field of modern medicine, and the harm of NAFLD to human health will continue to increase in the near future. This paper reviews the relationship between NAFLD and various components of metabolic syndrome, including obesity, hyperglycemia, dyslipidemia and hypertension, by reviewing relevant literatures at home and abroad, aiming to provide reference for early warning and intervention of patients with non-alcoholic fatty liver disease. 2022 Vol. 29 (15): 36-39转43 [Abstract] ( 35 ) HTML (1 KB)  PDF (865 KB)  ( 134 ) 40 Effect of vascular risk factors on the onset of benign paroxysmal positional vertigo in the elderly FENG Yingqiu; ZHOU Nina; LIU Qinglian;JIN Zhanguo Objective To analyze the effect of cardiovascular risk factors (CVRFs) on benign paroxysmal positional vertigo (BPPV) in the elderly. Methods A total of 34 elderly patients with BPPV in the General Department of Balizhuang Community Health Service Center from October 2018 to October 2020 were selected as the experimental group. During the same period, 34 elderly people who matched the age and gender of the experimental group and took physical examination in the Physical Examination Department in the same period, and had no history of BPPV were selected as the control group. Seven CVRFs indexes including body mass index (BMI), blood pressure, blood glucose, serum total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C) and high density lipoprotein cholesterol(HDL-C) as well as 2 carotid ultrasound diagnosis indexes including intima-media thickness (IMT) and atherosclerotic plaque were compared between two groups. Results There were no significant differences in CVRFs and incidence of carotid atherosclerotic plaque between the two group (P＞0.05). The severity of carotid IMT in the BPPV group was higher than that in the control group, and the difference was statistically significant (P＜0.05). Conclusion CVRFs and carotid atherosclerotic plaque are not independent risk factors of BPPV in the elderly, and carotid IMT can be used as a reference index for risk assessment and early warning of senile BPPV. 2022 Vol. 29 (15): 40-43 [Abstract] ( 35 ) HTML (1 KB)  PDF (612 KB)  ( 77 ) 44 Application effect of noninvasive ventilator combined with Tiotropium Bromide in elderly patients with acute exacerbation of chronic obstructive pulmonary disease complicated with type Ⅱrespiratory failure WANG Zhen；LUO Zhongming；SHU Dan；GONG Wei Objective To investigate the effect of noninvasive ventilator combined with Tiotropium Bromide in patients with chronic obstructive pulmonary disease (COPD). Methods A total of 124 patients with acute exacerbation of COPD complicated with type Ⅱrespiratory failure treated in Guangxin District People′s Hospital, Shangrao City from September 2020 to May 2021 were selected. The patients hospitalized from September 2020 to December 2020 were selected as the control group, and the patients hospitalized from January 2021 to May 2021 were selected as the observation group, with 62 cases in each group. The control group was treated with BiPAP double-level non-invasne ventilator ventilation. The observation group was treated with tiotropium bromide on the basis of the control group. The levels of arterial blood gas indexes, inflammatory factors and pulmonary function indicators were compared between the two groups. Results After 3 days of treatment, the pH value, the arterial partial pressure of oxygen (PaO2) was higher than that before treatment, and the partial pressure of carbon dioxide (PaCO2) was lower than that before treatment, and the pH value and PaO2 of the observation group were higher than those of the control group three days after treatment,and PaCO2 was lower than that of the control group, with statistical significances (P＜0.05). After 2 weeks of treatment,tumor necrosis factor-α(TNF-α),C-reactive protein(CRP)were lower than those before treatment, and interleukin-10 (IL-10) was higher than that before treatment, and TNF-α, CRP in observation group were lower than thaose in the control group, and IL-10 was higher than that in the control group, the differences were statistically significant (P＜0.05). After 2 weeks of treatment, the first second forced vital capacity (FEV1), forced vital capacity (FVC) and FEV1/FVC of the two groups were higher than those before treatment, and FVC, FEV1 and FEV1/FVC in the observation group were higher than those in the control group, the differences were statistically significant (P ＜0.05). Conclusion Noninvasive ventilator combined with Tiotropium Bromide can improve arterial blood gas indexes and pulmonary function, reduce inflammatory reaction and improve treatment effect in patients with acute exacerbation of COPD complicated with typeⅡrespiratory failure. 2022 Vol. 29 (15): 44-46转50 [Abstract] ( 33 ) HTML (1 KB)  PDF (602 KB)  ( 17 ) 47 Curative effect of choledochoscope combined with laparoscopic cholecystic duct exploration in the treatment of bile duct calculus SU Haoyuan；WANG Gang；YUAN Jianmao Objective To investigate the efficacy of choledochoscope combined with laparoscopic cholecystic duct exploration in the treatment of bile duct calculus. Methods A total of 121 patients with gallbladder complicated with choledocholithiasis admitted to the Department of Hepatobiliary Surgery of Suzhou Ninth People′s Hospital from August 2019 to July 2021 were retrospectively selected as the subjects, according to the operation method, they were divided into observation group (60 cases) and control group (61 cases). The observation group adopted laparoscopic trans-cystic duct common bile duct exploration, the control group adopted the laparoscopic common bile duct exploration. The cases of perioperative and postoperative complications were compared between the two groups. Results The postoperative catheter time, exhaust time and postoperative hospital stay in the observation group were shorter than those in the control group, the differences were statistically significant (P＜0.05). There were no statistical differences in operation time,blood loss and postoperative complications between the two groups (P＞0.05). Conclusion Laparoscopic cholecystectomy combined with cholecystectomy and cholecystectomy is feasible and effective, which can avoid T tube drainage after cholecystectomy, and significantly shorten postoperative catheter time and hospital stay. 2022 Vol. 29 (15): 47-49转50 [Abstract] ( 36 ) HTML (1 KB)  PDF (577 KB)  ( 29 ) 51 Application of modified indwelling gastric tube method based on anatomical structure in patients with severe traumatic brain injury with tracheotomy TANG Min Objective To explore the application of modified gastric tube indwelling method based on anatomical structure in patients with severe traumatic brain injury with tracheotomy effect. Methods A retrospective analysis was performed on 98 patients with severe craniocerebral trauma treated in the Second Affiliated Hospital of Nanhua University from June 2019 to June 2020. According to the different methods of gastric tube implantation, they were divided into control group (45 cases) and observation group (53 cases). The control group received conventional nasogastric tube placement, while the observation group received modified indignant gastric tube placement based on anatomical structure. The indexes of nasogastric tube placement, the changes of vital signs before and during the intubation and the occurrence of adverse reactions were compared between the two groups. Results The first and total success rates of the observation group were higher than those of the control group, and the average time of the first gastric tube implantation was shorter than that of the control group, the differences were statistically significant (P＜0.05). There were no statistically significant differences in heart rate, mean arterial pressure, respiratory rate and blood oxygen saturation before catheterization between the two groups (P＞0.05). There were no significant differences in heart rate, mean arterial pressure, respiratory rate and blood oxygen saturation before and after catheterization in observation group (P＞0.05). In the control group, the heart rate, mean arterial pressure and respiratory rate were higher than those before catheterization,while the oxygen saturation was lower than those before catheterization, the differences were statistically significant (P＜0.05). The heart rate, mean arterial pressure and respiratory rate of patients in the observation group were lower than those in the control group, and oxygen saturation was higher than that in the control group, the differences were statistically significant (P＜0.05). The incidence of cough, nausea and vomiting and nasal mucosal injury in observation group were lower than those in control group, the differences were statistically significant (P＜0.05). Conclusion Compared with conventional gastric tube placement, the improved anatomical structure-based indwelling gastric tube method has a higher success rate, has less impact on the patients′ vital signs, and has a lower incidence of adverse reactions. 2022 Vol. 29 (15): 51-54 [Abstract] ( 34 ) HTML (1 KB)  PDF (606 KB)  ( 12 ) 55 Application effect of Salvianolate combined with Esmolol in elderly patients with coronary heart disease and angina pectoris MU Shaoning；WEN Mingxin；WU Chunyan Objective To explore the application effect of Salvianolate combined with Esmolol in elderly patients with coronary heart disease and angina pectoris. Methods A total of 98 elderly patients with coronary heart disease and angina pectoris admitted to the Department of Emergency, Liaocheng Hospital of Traditional Chinese Medicine from September 2019 to September 2021 were selected as the study subjects. They were divided into observation group and control group by random number table method, with 49 cases in each group. Control group was treated with Esmolol,and observation group was treated with Salvianolate on the basis of control group. The efficacy, cardiac function, hemodynamics, oxidative stress index and medication safety of the two groups were compared before and after treatment.Results The total effective rate of observation group was higher than that of control group, the difference was statistically significant (P＜0.05). Before treatment, there were no statistically significant differences in left ventricular ejection fraction (LVEF), left ventricular end diastolic diameter (LVEDD) and left ventricular end systolic diameter (LVESD) between the two groups (P＞0.05). After treatment, the LVEF of the two groups were higher than those before treatment,LVEDD and LVESD were lower than those before treatment, LVEF of observation group was higher than that of the control group, LVEDD and LVESD were lower than those of the control group, the differences were statistically significant (P＜0.05). After treatment, fibrinogen, high whole blood viscosity, low whole blood viscosity and plasma viscosity in the two groups were lower than those before treatment, and fibrinogen, high whole blood viscosity, low whole blood viscosity and plasma viscosity in observation group were lower than those in control group, the differences were statistically significant (P＜0.05). After treatment, malondialdehyde (MDA) in both groups were lower than those before treatment,superoxide dismutase (SOD) were higher than those before treatment, and the MDA level in observation group was lower than that in control group, SOD level was higher than that in control group, the differences were statistically significant(P＜0.05). There was no statistically significant difference in the total incidence of adverse reactions between the two groups (P＞0.05). Conclusion Salvianolate combined with Esmolol in the treatment of angina pectoris in elderly patients with coronary heart disease can improve cardiac function, improve hemodynamics, reduce oxidative stress level, with significant efficacy and good safety, high application value. 2022 Vol. 29 (15): 55-58 [Abstract] ( 27 ) HTML (1 KB)  PDF (578 KB)  ( 20 ) 59 Effect of optimizing emergency gastroscopy on the treatment of gastrointestinal bleeding LIN Lichun； LIANG Tianyu； CHEN Li ；PAN Xiaoyan Objective To explore the effect of optimizing the process of emergency gastroscopy on the treatment of gastrointestinal bleeding. Methods A total of 50 patients with acute gastrointestinal bleeding treated in the First Affiliated Hospital of Fujian Medical University from January to December 2019 were selected as the control group, and 50 patients with acute gastrointestinal bleeding treated in the same hospital from January to December 2020 were selected as the observation group. Patients in the control group were examined and treated with routine emergency gastroscopy, and patients in the observation group were examined and treated with optimized emergency gastroscopy. The success rate of hemostasis, the time spent in each link of the diagnosis and treatment process and the satisfaction of patients′ families were compared between the two groups. Results The success rate of hemostasis in the observation group (98.00%) was higher than that in the control group (84.00%), and the difference was statistically significant (P＜0.05). The reception time, admission to gastroscopy, hemostasis time and hospitalization time in the diagnosis and treatment process in the observation group were shorter than those in the control group, and the differences were statistically significant (P＜0.05). The total satisfaction of patients in the observation group (96.00%) was higher than that in the control group(80.00), the difference was statistically significant (P＜0.05). Conclusion Optimization of emergency gastroscopy procedure is beneficial to improve the treatment effect of gastrointestinal bleeding patients, shorten the diagnosis and treatment time effectively, and improve patient satisfaction. 2022 Vol. 29 (15): 59-61转69 [Abstract] ( 28 ) HTML (1 KB)  PDF (871 KB)  ( 30 ) 62 Effect of 3D printing combined with wrist arthroscopy, minimally invasive precision reduction and percutaneous internal fixation in the treatment of distal radius fractures involving the articular surface PENG Songgen；LUO Yi；WU Xiang；LI Shengshan；GUO Qiaohong Objective To explore the effect of 3D printing combined with wrist arthroscopy, minimally invasive precision reduction and percutaneous internal fixation in the treatment of distal radius fractures involving the articular surface. Methods A total of 30 patients with distal radius fractures involving the articular surface who were admitted to the Shunde Peace Surgery Hospital from January to June 2021 were selected as the research objects, and they were divided into the control group and the observation group using a random number table method, with 15 cases in each group. Both groups of patients were treated with percutaneous internal fixation. The control group used wrist arthroscopy with minimally invasive precision reduction surgery alone, and the observation group used 3D printing combined with wrist arthroscopy for minimally invasive precision reduction surgery. The surgery time, intraoperative blood loss,hospital stay, surgical treatment costs and other related indicators of the two groups were compared. The wrist joint mobility such as palm inclination angle, ulnar deflection angle, dorsal extension angle and radial deviation angle, visual analog score (VAS) of pain and Gart-land-Werley (GLW) of the two groups before and after surgery were observed, and the incidence of complications such as articular surface irregularities and wrist arthritis of the two groups were recorded. Results The surgery time and hospital stay of the observation group were shorter than those of the control group, the intraoperative blood loss was lower than that of the control group, the surgical treatment costs of the observation group were lower than those of the control group, the differences were statistically significant (P＜0.05). The ulnar deflection angle, dorsal extension angle, and radial deflection angle of the observation group after surgery were all higher than those of the control group, and the VAS score and the GLW score of the observation group after surgery were lower than those of the control group, the differences were statistically significant (P＜0.05). The incidence of postoperative complications in the observation group was 13.33% (2/15), which was lower than 33.33% (5/15) in the control group, the difference was statistically significant (P ＜0.05). Conclusion 3D printing combined with wrist arthroscopy, minimally invasive precision reduction and percutaneous internal fixation in the treatment of distal radius fractures involving the articular surface can effectively improve the surgery efficiency and reduce the risk of injury and medical burden caused by the surgery. This treatment scheme has a positive impact on improving the range of motion and function of the patient′s wrist, and can also reduce the risk of complications such as postoperative wrist arthritis and articular surface irregularities, it has high clinical popularization value. 2022 Vol. 29 (15): 62-65 [Abstract] ( 33 ) HTML (1 KB)  PDF (488 KB)  ( 27 ) 66 Clinical effect of proximal femoral intramedullary nail in the treatment of elderly osteoporotic femoral intertrochanteric fractures MI Shidi Objective To investigate the clinical effect of different proximal femoral intramedullary nails in the treatment of osteoporotic femoral intertrochanteric fracture in the elderly. Methods A total of 80 elderly patients with osteoporotic femoral intertrochanteric fracture in the Department of Traumatology and Orthopedics of Chengdu Orthopedic Hospital of Jinjiang District of Chengdu City in Sichuan Province from January 2019 to June 2021 were selected as the research objects. They were divided into the observation group and the control group by computer two-color ball grouping method, with 40 patients in each group. The observation group was treated with interochanteric antegrade nai(interTAN), the control group was treated with proximal femoral nails antirotation (PFNA). The surgical treatment effect,patient recovery index and the incidence of surgical complications were compared between the two groups. Results The total effective rate of surgical treatment in the observation group was significantly higher than that in the control group,the difference was statistically significant (P＜0.05). The weight-bearing time and fracture healing time in the observation group were shorter than those in the control group, the differences were statistically significant (P＜0.05). The Harris score of hip function in the observation group was significantly higher than that in the control group, the difference was statistically significant (P＜0.05). The incidence of postoperative complications in the observation group was lower than that in the control group, the difference was statistically significant (P＜0.05). Conclusion For the treatment of elderly patients with osteoporotic femoral intertrochanteric fracture, interTAN operation has a significant effect in restoring the joint function and shortening the rehabilitation time of patients, and the treatment safety is higher, which is worthy of clinical application. 2022 Vol. 29 (15): 66-69 [Abstract] ( 32 ) HTML (1 KB)  PDF (477 KB)  ( 28 ) 70 Effect of small needle knife combined with Zhengqing Fengtongning Injection in the treatment of stenotic tenosynovitis of flexor digitorum LEI Haiping ；ZHENG Lu Objective To analyze the effect of small needle knife combined with Zhengqing Fengtongning Injection in the treatment of stenotic tenosynovitis of flexor digitorum. Methods A total of 60 patients with stenotic tenosynovitis of flexor digitorum from February 2018 to April 2021 were selected as the research objects, they were divided into the observation group and the control group according to random number table method, 30 cases in each group. The patients in the control group were treated with fixed-point interventional therapy of Zhengqing Fengtongning Injection, and the patients in the observation group were treated with small needle knife combined with fixed-point interventional therapy of Zhengqing Fengtongning Injection. The total effective rate of clinical treatment, rehabilitation time, pain score after treatment, quality of life score before and after treatment and treatment satisfaction were compared between the two groups. Results The total effective rate of the observation group was higher than that of the control group, the difference was statistically significant (P＜0.05). The rehabilitation time of patients in the observation group after treatment was shorter than that in the control group, and the VAS score in the observation group after treatment was lower than that in the control group, the differences were statistically significant (P＜0.05). There were no significant differences in the scores of physiological function, physical movement, social function, living state and spiritual vitality between the two groups before treatment (P＞0.05). After treatment, the scores of of physiological function, physical movement, social function, living state and spiritual vitality of the two groups were higher than those before treatment, and the scores of physiological function, physical movement, social function, living state and spiritual vitality of the observation group after treatment were higher than those of the control group, the differences were statistically significant (P＜0.05). The degree of total treatment satisfaction of the observation group was higher than that of the control group, the difference was statistically significant (P＜0.05). Conclusion Small needle knife combined with fixed-point interventional therapy of Zhengqing Fengtongning Injection can improve the treatment effect of stenotic tenosynovitis of flexor digitorum, promote the rehabilitation of patients, improve their quality of life and improve their treatment satisfaction. The overall application effect is ideal and worthy of recommendation. 2022 Vol. 29 (15): 70-73 [Abstract] ( 30 ) HTML (1 KB)  PDF (475 KB)  ( 28 ) 74 Analysis of thyroglobulin level in postoperative lymph node metastasis in patients with differentiated thyroid carcinoma GUO Lin； LI Peiting； KANG Xiaopeng； LU Tian； WU Chengjiu；WANG Longteng； XIAO Qiao； LI Jiexing Objective To analyze the level of thyroglobulin in lymph node metastasis in patients with differentiated thyroid cancer. Methods A total of 80 patients with differentiated thyroid cancer admitted to the Third Affiliated Hospital of Xiangya Medical College from December 2012 to January 2018 were retrospectively selected as the research objects.The patients were followed up for one year according to whether the patients had lymph node metastasis and the patients were divided into observation groups (12 cases, with lymph node metastasis) and the control group (68 cases,without lymph node metastasis). The levels of serum triglycerides (Tg), thyroglobulin antibodies (TgAb) and thyroidstimulating hormone (TSH) were compared between the two groups. Results Followed up half a year or one year later,the Tg level in the observation group was significantly higher than that in the control group (P＜0.05). The Tg (+) TgAb(-) rate, Tg (-) TgAb (+) rate, Tg (+) TgAb (+) rate, Tg (+) or TgAb (+) rate in the observation group were higher than those in the control group, the differences were statistically significant (P＜0.05). The normal rate of thyroid stimulating hormone (TSH), Tg (-) TgAb (-) rate in the observation group were lower than those in the control group, the differences were statistically significant (P＜0.05). Conclusion Tg is a better follow-up indicator for differentiated thyroid cancer. When monitoring serum Tg levels for a long time, it is not necessary to stop endocrine therapy routinely, but it is necessary to detect the serum anti-Tg level of patients at the same time. 2022 Vol. 29 (15): 74-76转80 [Abstract] ( 32 ) HTML (1 KB)  PDF (751 KB)  ( 85 ) 77 Application effect of pulmonary rehabilitation in the perioperative period of thoracoscopic lung cancer XIA Shaofeng；XIONG Jiajun；HU Yapei ；ZHU Xueyu ；ZHANG Shihao； CHEN Le ；FANG Zheng Objective To investigate the application of thoracoscopic pulmonary rehabilitation in perioperative period of lung cancer. Methods A total of 100 lung cancer patients who were selected from February 2020 to February 2021 in Department of Thoracic Surgery, the First People′s Hospital of Jiujiang City were retrospectively selected as the subjects. According to the perioperative treatment methods, 100 patients were divided into control group and observation group. The surgeries were performed by doctors in the same treatment group. Both groups received routine perioperative treatment of thoracoscopic lung cancer surgery, and the observation group received perioperative pulmonary rehabilitation treatment on the basis of the control group. The incidence of postoperative pulmonary complications (including pulmonary infection and empyema), postoperative hospital stay, forced expiratory volume in the first second (FEV1), maximum ventilation (MVV) and 6 min walking test (6MWT) were measured and recorded between the two groups. Results The incidence of postoperative pulmonary complications in the observation group was 12.00% (6/50), lower than 64.00% (27/50) in the control group, the difference was statistically significant (P＜0.05). The length of stay in the observation group was shorter than that in the control group, the difference was statistically significant (P＜0.05). The FEV1, MVV and 6MWT of the two groups after intervention were higher than those before intervention, the FEV1, MVV and 6MWT of the observation group after intervention were higher than those of the control group, the differences were statistically significant (P＜0.05). Conclusion The application effect of thoracoscopy in lung cancer perioperative period is good. 2022 Vol. 29 (15): 77-80 [Abstract] ( 37 ) HTML (1 KB)  PDF (472 KB)  ( 108 ) 81 Application effect of Yangzheng Mixture in patients with related anorexia in advanced non-small cell lung cancer SHI Shaoqing；HOU Boqun；BAO Wenbin Objective To explore the effect of Yangzheng Mixture in assisting patients with advanced non-small cell lung cancer-related anorexia. Methods From August 2019 to August 2020, 40 patients with non-small cell lung cancer who underwent radiotherapy at the Fifth Department of Oncology, Jiamusi Cancer Hospital, Heilongjiang Province were selected as the subjects of this study. According to the random number table method, they were divided into observation group and control group, with 20 cases in both groups. Patients in the control group were given oral Megestrol Acetate Tablets for treatment, and patients in the treatment group were given Yangzheng Mixture on the basis of the control group. After 3 weeks of treatment, the treatment effects of anorexia symptoms, the Karnofsky functional status score(KPS), the improvement of appetite and the incidence of adverse reactions were compared between the two groups of patients. Results After treatment, the total effective rate of appetite improvement in the treatment group was higher than that in the control group, with statistical significance (P＜0.05); after treatment, the appetite improvement rate in the treatment group was higher than that in the control group, with statistical significance (P＜0.05); after treatment, the total improvement rate of KPS score in the treatment group was higher than that of the control group, with statistical significance (P＜0.05); after treatment, the total adverse reaction rate of patients in the treatment group (35%) was lower than that of the control group (70%), with statistical significance (P＜0.05). Conclusion Yangzheng Mixture can effectively alleviate the related anorexia symptoms caused by radiotherapy in patients with non-small cell advanced lung cancer, improve the patient′s quality of life, and the drug has good clinical efficacy and safety, which is worthy of clinical reference and application. 2022 Vol. 29 (15): 81-83 [Abstract] ( 30 ) HTML (1 KB)  PDF (435 KB)  ( 18 ) 84 Application effect of Lysine Zinc Gluconate in children with rotavirus enteritis and benign convulsion DENG Tian；LIU Yi Objective To observe the application effect of Lysine Zinc Gluconate in children with rotavirus enteritis and benign convulsions. Methods A total of 80 children with rotavirus enteritis and benign convulsions who were admitted to the Second Affiliated Hospital of Yichun University from November 2019 to November 2020 were selected as the research objects, and they were divided into the observation group and the control group according to random number table method, with 40 cases in each group. The control group was treated with Ribavirin, and the observation group was treated with Ribavirin combined with Lysine Zinc Gluconate. The clinical efficacy and adverse reactions after 1 week of treatment of the two groups were compared between the two groups. The recurrence and transformation of epilepsy of the two groups were recorded during one-year follow-up. At the same time, the changes of levels of inflammatory factors before and after treatment were compared between the two groups. Results After treatment, The total effective rate of the observation group was 95.00%, which was higher than 77.50% of the control group, the difference was statistically significant (P＜0.05). The abatement time of vomiting, diarrhea and fever, dehydration correction time,stool formation time and hospital stay of the observation group were significantly shorter than those of the control group,and the number of convulsions of the observation group was significantly smaller than that of the control group, the differences were statistically significant (P＜0.05). After treatment, the level of CD4+ in the observation group was significantly higher than that in the control group, the levels of interleukin-6 (IL-6) and tumor necrosis factor α (TNF-α) of the observation group were significantly lower than those in the control group, the differences were statistically significant (P＜0.05). There was no significant difference in the recurrence rate between the two groups (P＞0.05), and there was no patients developing into epilepsy). There was no significant difference in the total incidence of adverse reactions between the two groups (P＜0.05). Conclusion Lysine Zinc Gluconate can effectively reduce the level of inflammatory factors in children with rotavirus enteritis with benign convulsion, enhance the body resistance of children, improve the clinical treatment effect and the prognosis. 2022 Vol. 29 (15): 84-87 [Abstract] ( 26 ) HTML (1 KB)  PDF (530 KB)  ( 17 ) 88 Clinical guidance and application analysis of the whole process management of blood glucose management team in gestational diabetes mellitus ZHU Minghui；HUANG Ting；ZOU Zhipeng Objective To explore the application and clinical guidance effect of the whole process management of blood glucose management team in patients with gestational diabetes mellitus. Methods From January 2020 to January 2021,96 patients with gestational diabetes mellitus admitted to the Department of Endocrinology of Pingxiang People′s Hospital were selected as research subjects. All the patients were diagnosed by oral 75 g glucose tolerance test in the outpatient department of the hospital, and the patients were divided into the control group and the observation group according to random number table methods, 48 cases in each group. The control group received a one-day clinic instruction of endocrinology, and the observation group combined with the whole process management of blood glucose management team, and urging patients to reexamine within 6 weeks to 6 months after delivery. The self-management level,the incidence of hypoglycemia, the compliance rate of fasting blood glucose, the compliance rate of postprandial blood glucose, the rate of postpartum prognosis and the incidence of maternal and neonatal complications were compared between the two groups. Results The scores of prevention and treatment of abnormal blood glucose, diet control, blood glucose monitoring, activity, medication and foot care in the observation group were higher than those in the control group, and the differences were statistically significant (P＜0.05). The incidence of hypoglycemia in the observation group after management was lower than that in the control group, and the difference was statistically significant (P＜0.05). The compliance rate of fasting blood glucose, the compliance rate of postprandial blood glucose, the rate of postpartum prognosis in the observation group after management were higher than those in the control group, and the differences were statistically significant (P＜0.05). The total incidence of polyhydramnios, premature rupture of membranes,puerperal infection and neonatal macrosomia, premature infants and neonatal hypoglycemia in the observation group after intervention were lower than those in the control group, and the differences were statistically significant (P＜0.05). Conclusion The whole process management of blood glucose management team for gestational diabetes mellitus patients is helpful to improve the self-management level of patients, reduce the incidence of maternal and neonatal complications, and improve the achievement rate of fasting blood glucose, postprandial blood glucose and postpartum outcome rate, which is worthy of popularization and application. 2022 Vol. 29 (15): 88-91 [Abstract] ( 30 ) HTML (1 KB)  PDF (531 KB)  ( 23 ) 92 Application study of standardized communication model based on situation-background-assessment-recommendation in hydraulic enema reduction of children with intussusception KANG Luhua Objective To study the application effect of standardized communication model based on situation-background-assessment-recommendation (SBAP) in hydraulic enema reduction of children with intussusception. Methods A total of 72 children who underwent hydraulic enema reduction in Ganzhou Maternal and Child Health Hospital from June 2019 to June 2021 were selected, they were divided into the control group and the observation group according to random number table method, with 36 cases in each group. The control group received conventional communication model, and the observation group received standardized communication model based on SBAP. The treatment conditions(the success rate of first reduction, the 24 h recurrence rate, operation time, anal exhaust time and length of hospital stay), the incidence rates of complications (intestinal perforation, diarrhea, vomiting and fever) and nursing quality were compared between the two groups. Results The success rate of first reduction in the observation group was higher than that in the control group, and the difference was statistically significant (P＜0.05). The 24 h recurrence rate, the incidence of complications in the observation group was lower than that in the control group, operation time, anal exhaust time, and length of hospital stay in the observation group were shorter than those in the control group, and the differences were statistically significant (P＜0.05). The nursing quality score of the observation group was higher than that of the control group,and the difference was statistically significant(P＜0.05).Conclusion Standardized communication model based on SBAP can improve the therapeutic effect of hydrostatic enema reduction on children with intussusception,and reduce the incidence rates of complications and recurrence rate, It is worthy of clinical promotion and application. 2022 Vol. 29 (15): 92-94 [Abstract] ( 31 ) HTML (1 KB)  PDF (529 KB)  ( 17 ) 95 Application effect of Progesterone Soft Capsule combined with hysteroscopic electrotomy in the treatment of infertility patients with endometrial polyps LIU Cuixia Objective To investigate the application effect of progesterone soft capsule combined with hysteroscopic electrotomy in the treatment of infertility patients with endometrial polyps. Methods A total of 72 infertile patients with endometrial polyp who were treated in Macheng People′s Hospital from March 2018 to April 2019 were selected as the research objects, and they were divided into group A (36 cases) and group B (36 cases) by random ball-touching method.Group B was treated with hysteroscopic electrotomy, and group A was treated with Progesterone Soft Capsule on the basis of group B. Endometrial thickness, menstrual volume and pregnancy were compared between the two groups. Results The endometrial thickness of the two groups at 6 months and 12 months after surgery were lower than those at 3 months after surgery, the differences were statistically significant (P＜0.05). The endometrial thickness of the two groups at 12 months after surgery were lower than those at 6 months after surgery, the differences were statistically significant(P＜0.05). The endometrial thickness of group A at 3 months, 6 months, and 12 months after surgery were lower than those of group B, and the differences were statistically significant significance (P＜0.05). The menstrual volume of the two groups at 6 months and 12 months after surgery were more than those at 3 months after surgery, the differences were statistically significant (P＜0.05). The menstrual volume of the two groups at 12 months after surgery were more than those at 6 months after surgery, the differences were statistically significant (P＜0.05). But the menstrual volume of group A at 3 months, 6 months, and 12 months after surgery were less than those of group B, and the differences were statistically significant (P＜0.05). The 2-year pregnancy rate of group A was higher than that of group B, and the difference was statistically significant (P＜0.05). Conclusion Progesterone Soft Capsule combined with hysteroscopic electrotomy has a good effect on infertility patients with endometrial polyps, which can reduce the endometrial thickness and menstrual volume of patients, and significantly improve the pregnancy rate. 2022 Vol. 29 (15): 95-97 [Abstract] ( 27 ) HTML (1 KB)  PDF (522 KB)  ( 17 ) 98 Application effect of laparoscopic surgery combined with Mifepristone in endometriosis PAN Wenying；LI Qingqing；FENG Tingting Objective To explore the application effect of laparoscopic surgery combined with Mifepristone in endometriosis. Methods A total of 50 patients with endometriosis in the Affiliated Hospital of Binzhou Medical College from January 2016 to January 2018 were selected as research objects, and they were divided into the observation group and the control group according to random drawing, with 25 cases in each group. The observation group received laparoscopic surgery combined with Mifepristone treatment, and the control group received conventional treatment. The cure time, operation time, length of hospital stay, hospitalization cost, the complication rate and the recurrence rate, visual analogue scale (VAS) and climacteric symptom score (Kupperman modified score) were compared between the two groups. Results The operation time, length of hospital stay and cure time of the observation group were shorter than those of the control group, and the hospitalization cost of the observation group was less than that of the control group,the differences were statistically significant (P＜0.05). The incidence of complications and the recurrence rate in the observation group were lower than those in the control group, the differences were statistically significant (P＜0.05). Before treatment, there was no significant difference in the VAS score and Kupperman score between the two groups (P＞0.05).The VAS score and Kupperman score of the two groups after treatment were lower than those before treatment, the differences were statistically significant (P＜0.05). After treatment, the VAS score and Kupperman score of the observation group were lower than those of the control group, the differences were statistically significant (P＜0.05). Conclusion Laparoscopic surgery combined with Mifepristone is effective in the treatment of endometriosis 2022 Vol. 29 (15): 98-100 [Abstract] ( 35 ) HTML (1 KB)  PDF (519 KB)  ( 24 ) 101 Diagnostic value of transvaginal ultrasonography combined with hysteroscopy in endometrial cancer TIAN Yuan Objective To explore the diagnostic value of transvaginal ultrasonography combined with hysteroscopy for endometrial cancer. Methods From January 2019 to the end of April 2021, 93 patients with endometrial abnormalities by transvaginal ultrasonography and further performed with hysteroscopy who were admitted in Xiamen Hospital of Traditional Chinese Medicine were retrospectively selected as the research subjects. Transvaginal ultrasonography combined with hysteroscopy was performed using the surgical pathological results as the gold standard. The sensitivity,specificity, positive predictive value, negative predictive value and accuracy of different diagnostic methods were compared with gold standard. Results Endometrial carcinoma was diagnosed by transvaginal ultrasonography in 8 cases,missed diagnosis in 2 cases and misdiagnosis in 1 case. 9 cases of endometrial carcinoma were diagnosed by transvaginal ultrasonography and hysteroscopy, 1 case was missed and 1 case was misdiagnosed. There were no statistically significant differences in sensitivity, positive predictive value, negative predictive value and accuracy of transvaginal ultrasonography combined with hysteroscopy and transvaginal ultrasonography (P＞0.05). Conclusion Transvaginal ultrasound and transvaginal ultrasonography combined with hysteroscopy in patients with endometrial cancer can toth effectively improve the clinical diagnosis rate, which can be used as a method for screening and disease evaluation of endometrial cancer, and provide an effective reference for clinical treatment of endometrial cancer. 2022 Vol. 29 (15): 101-103 [Abstract] ( 28 ) HTML (1 KB)  PDF (401 KB)  ( 16 ) 104 Diagnostic value of ultrasound elastography combined with detection of vascular endothelial growth factor, carcinoembryonic antigen and carbohydrate antigen 15-3 in breast cancer YE Gao；WANG Kai Objective To explore the diagnostic value of ultrasound elastography combined with vascular endothelial growth factor(VEGF),carbohydrate antigen 15-3(CA15-3)and carcinoembryonic antigen(CEA)in breast cancer. Methods A total of 100 breast cancer patients treated in Shenzhen Baoan District Central Hospital of Shenzhen City from January 2020 to August 2021 were randomly selected as the test group, and 100 patients with benign breast nodules who were treated in Shenzhen Baoan District Central Hospital of Shenzhen City during the same period were selected as the control group and 100 healthy patients were selected as the healthy group. All three groups were diagnosed by ultrasound elastography, and VEGF, CEA and CA15-3 were detected. The diagnostic efficacy of ultrasound elastography, VEGF, CEA, CA15-3 and combined detection in breast cancer was analyzed (sensitivity [SEN], specificity [SPE]and accuracy [ACC]). Results Serum VEGF, CEA and CA15-3 levels in experimental group were higher than those in control group and healthy group, the differences were statistically significant (P＜0.05). SPE, SEN and ACC of ultrasound elastography, VEGF, CEA and CA15-3 combined detection were higher than those of each single detection. The receiver operating characteristic (ROC) curve was plotted with SEN as X-axis and 1-SPE as Y-axis. According to ROC curve, the combined detection of ultrasound elastic imaging, VEGF, CEA and CA15-3 had higher diagnostic efficacy for breast cancer than each single detection. The area under the curve (AUC) was 0.906 (95%CI=0.856-0.956, P＜0.05).Conclusion The combined detection of ultrasound elastography, VEGF, CEA and CA15-3 has outstanding clinical value in the diagnosis of breast cancer. It can significantly improve the diagnostic efficiency of breast cancer patients and provide scientific guidance for clinical diagnosis and treatment of breast cancer patients. 2022 Vol. 29 (15): 104-107 [Abstract] ( 31 ) HTML (1 KB)  PDF (423 KB)  ( 62 ) 108 Expression significance of multiple serum tumor markers in COPD acute exacerbation FU Dongqin； XU Zhijian； JIANG Yong Objective To investigate the expression significance of multiple serum tumor markers in acute exacerbation of chronic obstructive pulmonary disease (COPD). Methods A total of 80 COPD patients admitted to Fuzhou First People′s Hospital from July 2019 to December 2020 were selected as the research objects, and were divided into acute exacerbation group and stable stage group according to stages, with 40 cases in each group, and 40 healthy subjects in the same period were selected as the control group. Carcinoembryonic antigen (CEA), glycochain antigen 19-9 (CA19-9), carbohydrate antigen 125 (CA125) and neuron specific enolase (NSE) were detected and compared among the three groups. The correlation between NSE level and CEA, CA19-19 and CA125 levels were analyzed, and the diagnostic value of various serum tumor markers in the acute exacerbation of COPD by single and combined detection were analyzed. Results CEA, CA19-9, CA125 and NSE levels in COPD acute exacerbation group were higher than those in control group and stable group, with statistical significance (P＜0.05). CA19-9 and CA125 in stable group were higher than those in control group, the difference was statistically significant (P＜0.05). NSE levels were negatively correlated with CEA, CA19-19 and CA125 levels, while CA125 levels were positively correlated with CEA and CA19-9 levels.The level of CA19-9 was positively correlated with CEA level (P＜0.05). In single test, the sensitivity of CA125 was higher, reaching 65.0%; CEA had a high specificity, reaching 85.0%. The sensitivity and specificity of CEA, CA19-9,CA125, and NSE were determined, reached 92.5%, 91.3%, respectively. Conclusion COPD acute weighting period was raised in serum tumor markers CEA, CA19-19, CA125, and NSE levels, and detected that it can help to judge patients with COPD in clinical practice to provide a basis for developing scientific treatment programs. 2022 Vol. 29 (15): 108-111 [Abstract] ( 31 ) HTML (1 KB)  PDF (511 KB)  ( 22 ) 112 Diagnostic value of gastroscopic biopsy in gastric high-grade intraepithelial neoplasia WU Qi；ZHAO Wenxing Objective To investigate the diagnostic value of gastroscopic biopsy in gastric high-grade intraepithelial neoplasia. Methods A total of 82 patients diagnosed with gastric high-grade intraepithelial neoplasia who were admitted to the Affiliated Hospital of Heze Medical College from August 2018 to August 2021 were selected as the research subjects. The positive detection rate of early gastric high-grade intraepithelial neoplasia, developmental gastric highgrade intraepithelial neoplasia and total gastric high-grade intraepithelial neoplasia were analyzed using surgical pathological biopsy as the gold standard, and the consistency between gastroscopy and surgical pathological biopsy was calculated. Results The positive rate of early gastric high-grade intraepithelial neoplasia was 50.00% (41/82), that of developing gastric high-grade intraepithelial neoplasia was 47.56% (39/82), and that of total gastric high-grade intraepithelial neoplasia was 97.56% (80/82). There were no significant differences compared with surgical pathology (51.22%[42/82], 48.78% [40/82], 100.00% [82/82]). The consistency between the diagnosis of high-grade intraepithelial neoplasia of the stomach by gastroscopy biopsy and the surgical pathological section was tested with Kappa=0.833, indicating a good consistency. Conclusion The results of gastric biopsy in patients with gastric high-grade intraepithelial neoplasia are consistent with the results of surgical pathological biopsy, and the clinical diagnostic value is high, which is worthy of recommendation. 2022 Vol. 29 (15): 112-114 [Abstract] ( 27 ) HTML (1 KB)  PDF (516 KB)  ( 80 ) 115 Clinical diagnosis value of serum anti-Mullerian hormone combined with sex hormone detection for polycystic ovary syndrome ZHONG Lei；XIAO Zuomiao； LIU Yan； XIE Haiyan； QIU Yumei Objective To investigate the clinical diagnostic value of serum anti-Mullerian hormone (AMH) combined with follicle stimulating hormone (FSH), luteinizing hormone (LH) and testosterone (T) detection for polycystic ovary syndrome (PCOS). Methods Clinical data of 50 PCOS patients admitted to People′s Hospital of Ganzhou City from June 2018 to June 2019 were retrospectively analyzed and included in the PCOS group. In addition, 30 other infertility patients admitted to People′s Hospital of Ganzhou City during the same period were selected as the other infertility group,and 30 healthy patients who underwent routine physical examination during the same p eriod were selected as the healthy control group. The levels of AMH, FSH, LH and T in all the selected subjects were examined, and the levels of AMH and sex hormones in the three groups were compared. Receiver operating characteristic (ROC) curves were drawn to analyze the clinical value of single and combined detection of AMH, FSH, LH and T in the diagnosis of PCOS. Results The levels of AMH, FSH, LH and T in PCOS group were higher than those in other infertility groups and healthy control group, and the levels of AMH, FSH, LH and T in other infertility groups were higher than those in control group, the differences were statistically significant (P＜0.05). ROC curve results showed that the areas under the curve of AMH, FSH, LH and T were 0.720, 0.693, 0.534, 0.703 and 0.989 respectively for the diagnosis of PCOS, which had certain diagnostic efficiency, and the combined detection had the highest diagnostic efficiency. Conclusion The use of AMH combined with FSH, LH and T in the diagnosis of PCOS patients has high application value, which can increase the disease detection rate and provide more reference for clinical diagnosis. 2022 Vol. 29 (15): 115-117转120 [Abstract] ( 32 ) HTML (1 KB)  PDF (515 KB)  ( 54 ) 118 Diagnostic value of Candida mannan antigen and IgG antibody in patients with invasive candidiasis WEI Xiaorong；WANG Bailian；HUANG Lixiu；GUO Ling Objective To investigate the diagnostic effect and value of Candida mannan (Mn) antigen and IgG antibody in patients with invasive candidiasis. Methods A total of 113 patients with suspected invasive Candidiasis in Wuming Hospital of Guangxi Medical University from January 2018 to April 2021 were selected as subjects. Enzyme-linked immunosorbent assay was used to determine Candida specific IgG antibody and Mn antigen in patients, and the ROC curve was drawn based on the results of sterile body fluid culture or histopathological examination as the gold standard to analyze the diagnostic efficacy of Candida specific IgG antibody, Mn antigen and combined detection for invasive Candida. Results 105 of 113 suspected invasive Candidiasis patients were confirmed by gold standard, with a diagnosis rate of 92.92%. 89 cases were diagnosed with Mn antigen, and the coincidence rate with gold standard diagnosis was 78.76%. 96 cases were confirmed by IgG antibody, and the diagnostic coincidence rate was 83.19%. 102 cases were confirmed by combined detection, and the diagnostic coincidence rate was 93.81%. ROC curve results showed that the sensitivity and specificity of combined detection of Mn antigen and IgG antibody were 95.24% and 75.00%, respectively, and AUC was 0.894. Conclusion Candida IgG antibody can be used in patients with invasive candidiasis to obtain a higher diagnostic coincidence rate. Combined with Mn antigen detection can help improve the diagnostic efficiency and guide clinical diagnosis and treatment. 2022 Vol. 29 (15): 118-120 [Abstract] ( 31 ) HTML (1 KB)  PDF (528 KB)  ( 17 ) 121 Application value of sandplay in improving the cooperation ability of nursing team in operating room RAO Lie； WANG Liang ；XU Jiaojiao； ZHANG Chunxia Objective To explore the effect of sandplay method on the cooperation ability of nursing team in operating room. Methods A total of 50 nurses in the operating room of Jiujiang Hospital of Traditional Chinese Medicine were selected as the research objects. According to odd and even number grouping method, they were divided into 5 groups,with 10 nurses in each group. During the three month period, each group was trained in group sandplay twice a month,once a hour using the blind principle. A sandplay therapist of Jiujiang Hospital of Traditional Chinese Medicine was responsible for the arrangement and execution of sandplay. The nursing team cooperation and patients′ satisfaction before and after sandplay intervention were compared. Results After the intervention, the scores of trust and support, team mental model, team leadership and team orientation of nursing team were higher than those before the intervention, and the differences were statistically significant (P＜0.05). After the intervention, the patients′ total satisfaction was improved than that before intervention, and the difference was statistically significant (P＜0.05). Conclusion The introduction of sandplay into the management of operating room nursing team can effectively improve the communication and cooperation ability of nursing team. It can not only create a good atmosphere of operation cooperation, but also provide good conditions for the patients′ safety and improve the satisfaction of patients. 2022 Vol. 29 (15): 121-123 [Abstract] ( 29 ) HTML (1 KB)  PDF (522 KB)  ( 49 ) 124 Analysis of 116 serious adverse drug reactions WANG Shiyun；LUO Chunyang；PENG Guojiang；ZHOU Jianjun；WANG Shiyu Objective To analyze the occurrence and characteristics of serious adverse drug reaction (ADR) in Affiliated Hospital of Xiangnan University (hereinafter referred to as "our hospital") from July 2016 to June 2021, in order to provide reference for ensuring clinical safety and rational drug use. Methods Serious ADR case reports reported by our hospital to national ADR monitoring network from July 2016 to June 2021 were collected for statistical analysis. Results A total of 861 cases of ADR were reported from July 2016 to June 2021, including 116 cases of serious ADR(13.47%) and 27 new serious ADR reports (3.14%). Males (61 cases) were slightly more than females (54 cases), and the majority of patients were over 40 years old (78.45%). Intravenous infusion was the main route of administration(81.03%). Antitumor drugs and antibacterial drugs caused most serious ADR. Serious ADR mainly causes systemic damage, including anaphylactic shock, bone marrow suppression, fever, liver and kidney function injury and so on.Conclusion It is suggested to strengthen the monitoring of ADR and serious ADR,especially antitumor drugs and antibacterial drugs, so as to prevent and reduce serious injury of patients with serious ADR and ensure the safety of clinical medication. 2022 Vol. 29 (15): 124-127 [Abstract] ( 26 ) HTML (1 KB)  PDF (581 KB)  ( 32 ) 128 Analysis of mental health status and influencing factors of patients with severe acute pancreatitis after treatment TIAN Tian； LIU Ya′nan； ZHOU Zhaoxu Objective To observe the mental health status of patients with severe acute pancreatitis after treatment and analyze its influencing factors. Methods A total of 86 patients with severe acute pancreatitis admitted to Heilongjiang Provincial Hospital from July 2020 to June 2021 were selected as the research objects. After 1 month of treatment, use the hospital anxiety and depression scale (HADS) to assess the patients′ mental health, record the patients′ general information, and record the data needed for the research, including possible influencing factors, logistic regression analysis was used to analyze the influencing factors of mental health of patients with severe acute pancreatitis after treatment. Results After 1 month of treatment, 38 patients with severe acute pancreatitis had poor central management, accounting for 44.19%. There were significant differences in education level, presence or absence of complications, social support rating scale (SSRS) score, and adaptation, partnership, growth, affection and resolve (APGAR) score between the mental illness group and the mentally well group, the differences were statistically significant (P＜0.05). The other general information between the two groups was not statistically significant (P＞0.05). The logistic regression analysis showed that the education level of junior high school and below, had concurrent symptoms were risk factors for patients with severe acute pancreatitis after treatment (β＞0, OR＞1, P＜0.05). SSRS score and APGAR score were protective factors for patients with severe acute pancreatitis after treatment (β＜0, OR＜1, P＜0.05). Conclusion The psychological problems of patients with severe acute pancreatitis after treatment may be related to factors such as junior high school and below education level, complications, low SSRS score, and low APGAR score. 2022 Vol. 29 (15): 128-130转134 [Abstract] ( 33 ) HTML (1 KB)  PDF (577 KB)  ( 80 ) 131 Investigation on postoperative continuous nursing needs of patients with colonic polyps undergoing daytime surgery WANG Fang ；WANG Min； YANG Wenxia ；YIN Huaying ；WANG Jinxiao Objective To investigate the need of postoperative continuous nursing in patients undergoing day surgery for colonic polyps, and to provide basis for future health education and follow-up after discharge. Methods A total of 130 patients who underwent day surgery for colonic polyps in the second ward of department of Gastroenterology, the Affiliated Hospital of Binzhou Medical College from January 1 to December 31, 2020 were selected as the research objects. A self-made questionnaire was used to investigate the continuous nursing needs of patients undergoing day surgery for colonic polyps, and the results were statistically analyzed. Results Patients with day operation for colonic polyps had a high need for continuous nursing after operation, accounting for 85.71%. The evaluation of patients′ needs for continuous nursing of colonic polyps during day surgery was related to occupation, residence style and age, the differences were statistically significant (P＜0.05). The top three requirements for postoperative continuous nursing of patients undergoing day surgery for colonic polyps were observation and nursing guidance for postoperative complications,dietary guidance for postoperatively, and postoperative healthy lifestyle guidance. There were various ways for patients to obtain health education, but the main ones were to establish health education network platforms (establishing wechat groups or public accounts, etc.) and to provide discharge health guidelines. Conclusion Colonic polyps ambulatory surgery patients with a high demand for health education after surgery, clinical medical staff should take targeted measures according to the characteristics of day surgery, the content of patients′ needs, the ways patients want to obtain their needs and so on, provide high quality nursing and health guidance to the patients, reduce complications, ensure the safety of patients and promote their early recovery. 2022 Vol. 29 (15): 131-134 [Abstract] ( 25 ) HTML (1 KB)  PDF (563 KB)  ( 45 ) 135 Application of the first-level quality control based on information platform in nursing quality management of encephalopathy ward QIU Pingxiang；YANG Lijun； CHEN Jiehan； LIU Wendao Objective To explore the application effect of the first-level quality control based on information platform in nursing quality management of encephalopathy ward. Methods Using the self-control research method, 22 nurses in the Ward of Department of Encephalopathy of Guangdong Hospital of Traditional Chinese Medicine from January 2019 to May 2020 were selected as the research objects. From January to August 2019, the traditional first-level quality control mode was applied by nurses as the control group, controlled the nursing medical records of 37 patients; and the nurses applying first-level quality control based on information platform from September 2019 to May 2020 were used as the observation group, controlled the nursing records of 37 patients. The time of nurses′ information input, patient information query, the speed of knowing the results of quality control information and the quality of quality control were compared between the two groups. Results The time for nurses′ information input and patient information query in the observation group were shorter than those in the control group, the nurses′ speed of knowing the results of quality control information was faster than that in the control group, and the scores of each dimension of nursing quality control were higher than those in the control group, and the differences were statistically significant (P＜0.05). Conclusion The first-level quality control based on information platform can significantly shorten the quality control time of nurses in the encephalopathy ward, and improve the speed of nurses′ knowing the results of quality control information, nursing quality control efficiency and quality. It is worthy of clinical application and promotion. 2022 Vol. 29 (15): 135-138 [Abstract] ( 30 ) HTML (1 KB)  PDF (549 KB)  ( 52 ) 139 Enlightenment of United States repackaged drugs supervision on China′s drug dismantling WANG Huiling； ZHUO Shengnan； YUAN Dongdong； LIU Wei Dismounted drugs can reduce the burden of patients, waste and pollution of the environment. China lacks specific standards and requirements for the management of dismounted drugs, and there are more problems with dismounted drugs, mainly including substandard environmental hygiene, improper operation, non-standard packaging materials, and unclear methods of determining expiration dates. The United States regulatory policy for repackaged drugs is more complete, with clear provisions for packaging and storage environment, equipment and personnel hygiene,repackaging operations, packaging materials, principles of determining expiration dates, labeling information and repackaging records. It is recommended that the relevant regulatory authorities in China learn from the relevant policies of the United States repackaging regulation, establish a sound management system for dismounted drugs, promote medical institutions to provide quality pharmacy services, and protect the safety of patients′ medication. 2022 Vol. 29 (15): 139-142 [Abstract] ( 31 ) HTML (1 KB)  PDF (514 KB)  ( 37 ) 143 Informationization management platform of hospital logistics applications in public emergencies ZHAO Tongguang ；FENG Tao； NIE Hongliang； YU Shibo Logistics informationization platform plays a key role in hospical logistics management, which could improve personnel management efficiency and equipment security management through associated datas of system modules, including personnel management, equipment lifecycle management, energy consumption analysis management, maintenance management, training management and file management. Meanwhile, the expansion of the platform could provide new management direction during the public emergencies. Through the practical application and information collation in public security emergencies, the ductility of the information platform has been improved, and corresponding adjustments have been made to the insufficiency of actual use. It is the extensibility, growth and accumulation of logistics information platform that make logistics get the opportunity of rapid growth in the future hospital management. At the same time, it also provides a solid data foundation for the specific information analysis of logistics operation. Affiliated Zhongshan Hospital of Dalian University made targeted adjustments to personnel management, training management,access control management, information reporting, hospital linen management, hospital medical waste management,material management, equipment maintenance prediction system, etc., based on the expansion of the information management platform and the needs of epidemic prevention and control. The hospital logistics information system makes seamless connection between the logistics staff and the medical front line in the epidemic situation. 2022 Vol. 29 (15): 143-147 [Abstract] ( 29 ) HTML (1 KB)  PDF (708 KB)  ( 25 ) 148 Effect of continuous improvement of health education mode in diabetes mellitus HUANG Xiaoting ；XU Jiamin； CHEN Yanfang； LUO Jiang ；WANG Yan ；ZHAO Fengying Objective To explore the continuous improvement of health education mode for diabetic patients, and to provide more effective and feasible propaganda and education mode for patients, help patients control blood sugar, effectively improve their self-management ability, and delay the occurrence and development of diabetic complications.Methods From February 2016 to January 2021, Department of Endocrinology of the First Affiliated Hospital of Fujian Medical University improved the health education mode for diabetes patients for 5 times on the original basis, including clinical pathway health education, diversified health education, intelligent management app education mode, electronic prescription health education mode, and whole-process metabolic disease management mode. Using random sampling method, 200 inpatients with diabetes were selected as the research objects every year, and the general data questionnaire and diabetes self-efficacy scale were used to investigate. Results Each improvement of health education mode effectively improved the self-management ability of diabetic patients. Fasting blood glucose and 2 h postprandial blood glucose in patients after education were higher than those before education, the differences were statistically significant(P＜0.05). In 2016, 2017, 2018, 2019, 2020, 2021, the total scores of self-efficacy after education were (126.12±32.72),(135.19±30.48), (140.44±27.18), (146.52±26.77) and (158.91±21.31) points respectively, were higher than those before education, which were (89.25±30.13), (93.59±34.68), (87.80±27.06), (96.34±34.99), (95.54±35.40) points respectively,the differences were statistically significant (P＜0.05). Conclusion Scientific and effective health education mode can help patients improve self-management efficiency, and diversified forms of health education can correct patients′ bad behavior and living habits. When educating and managing patients, medical staff should pay attention to whether this method is feasible and targeted, pay dynamic attention and improve in time, so as to provide more comprehensive and systematic health education for patients. 2022 Vol. 29 (15): 148-152 [Abstract] ( 23 ) HTML (1 KB)  PDF (566 KB)  ( 31 ) 153 Practice and exploration of the "modern apprenticeship" talent training model for optometry technology specialty WANG Rui With the upgrading of the optometry industry and enterprises, the optometry vision technology talents cultivated by a single school are far from being able to meet the needs of the industry for talents. The "modern apprenticeship" system is the establishment of school-enterprise joint enrollment (recruitment) and cooperative training. This article takes the optometry technology as an example, and through the practice of modern apprenticeship pilots, a talent training model of "centering on job competence, alternating work and learning, dual integration" has been formed, a"dual tutor" teaching team and a "dual place alternate" teaching model have been built. At the same time, it reflected on the shortcomings in practice, providing reference for further deepening education and teaching reform. 2022 Vol. 29 (15): 153-156 [Abstract] ( 27 ) HTML (1 KB)  PDF (554 KB)  ( 54 ) 157 Clinical application of anthropogram health education model in rehabilitation after cesarean section ZHAO Xue；WANG Sugui； WANG Haimei；WANG Hui Objective To explore the clinical application effect of anthropogram health education model in rehabilitation after cesarean section. Methods A total of 120 pregnant women who underwent cesarean section in the Department of Obstetrics of Huai′an Hospital Affiliated of Xuzhou Medical University from January 2018 to December 2019 were selected as the research objects. According to the random number table method, these pregnant women were divided into 60 cases in the control group and 60 cases in the experimental group. The control group used routine nursing measures after operation, while the experimental group used the anthropogram health education model. The postoperative exhaust time, postoperative out of bed activity time, wound healing time, hospitalization time, initial breastfeeding time,maternal quality of life and nursing satisfaction during hospitalization were compared between the two groups. Results The postoperative exhaust time, postoperative ambulation time, incision healing time and hospital stay of the experimental group were shorter than those of the control group, and the differences were statistically significant (P＜0.05).The duration of postoperative initial breastfeeding in the experimental group was shorter than that in the control group,and the difference was statistically significant (P＜0.05). After surgery, the scores of pain and trunk symptoms in the experimental group were lower than those in the control group, while the scores of sleep quality and mental state were higher than those in the control group, with statistically significant differences (P＜0.05). Postoperative nursing satisfaction of the experimental group was better than that of the control group, and the difference was statistically significant(P＜0.05). Conclusion The anthropogram health education model of human figure can effectively shorten the recovery time and the first breastfeeding time after childbirth and obstetrics surgery, improve the quality of life of puerparas and hospital satisfaction, which is worthy of widespread clinical promotion. 2022 Vol. 29 (15): 157-159转163 [Abstract] ( 28 ) HTML (1 KB)  PDF (537 KB)  ( 36 ) 160 Research on the application of micro-teaching combined with time node management in the skill teaching of nursing students LIU Jia；LIU Fang；XU Shan；LI Yang Objective To explore the application effect of micro-teaching combined with time node management in skill teaching of nursing students. Methods A total of 62 nursing students who practiced in Deyang People′s Hospital from May 2020 to September 2021 were selected as the research subjects. They were divided into control group (31 cases) and experimental group (31 cases) by random number table method. The control group used traditional methods for skill teaching, and the experimental group used micro-teaching combined with time point management for skill teaching. The teaching satisfaction, skill operation examination results, teaching quality level and qualified rate of the two groups were compared. Results The teaching satisfaction of experimental group was higher than that of control group,and the difference was statistically significant (P＜0.05). The performance of skill operation test group was higher than that of control group, and the difference was statistically significant (P＜0.05). The teaching quality score and pass rate of experimental group were higher than those of control group, and the differences were statistically significant (P＜0.05). Conclusion The application of micro-teaching combined with time node management in the skill teaching of nursing students can achieve good results, significantly improve the teaching quality, help nursing students better master skills and improve their satisfaction, and has high clinical promotion value. 2022 Vol. 29 (15): 160-163 [Abstract] ( 20 ) HTML (1 KB)  PDF (526 KB)  ( 19 ) 164 Application effect of continuous nursing on patients with respiratory failure PENG Chunling； LIU Xiaoxia； LAN Guixiang； CHEN Qinghua； ZHONG Yihua； FU Yanling Objective To explore the appliccation value of continuous nursing in patients with respiratory failure.Methods A total of 46 discharged patients with respiratory failure in the Department of Respiratory Medicine of Ganzhou Municipal Hospital from January 2019 to may 2020 were selected as the research objects. They were divided into the control group (23 cases) and the observation group (23 cases) according to random number table method. The control group received routine continuation nursing, while the observation group adopted continuous nursing. The compliance and the readmission rate of the two groups were compared. Results The compliance score of the observation group was higher than that of control group, and the difference was statistically significant (P＜0.05). The readmission rate of the observation group was 8.70%, which was lower than 26.09% of the control group, and the difference was statistically significant (P＜0.05). The scores of self-care ability and the total score in the observation group were higher than those in the control group, with statistical significance (P＜0.05). Conclusion The effect of continuous nursing for patients with respiratory failure is significant, which can effectively improve their compliance, significantly improve their self-care ability and reduce the readmission rate, so as to reduce the burden of patients and society, which is worthy of application. 2022 Vol. 29 (15): 164-166 [Abstract] ( 23 ) HTML (1 KB)  PDF (632 KB)  ( 19 ) 167 Intervention effect of WeChat platform continuity nursing on the health education of patients with inflammatory bowel disease ZHAO Shumin；WANG Liya ；SONG Qing； LUO Shuang Objective To explore the intervention effect of continuing care outside hospital on wechat platform on health education of patients with inflammatory bowel disease (IBD). Methods A total of 76 IBD patients hospitalized in the Department of Gastroenterology, Affiliated Hospital of Heze Medical College from July 2020 to July 2021 were selected as the research objects, and divided into control group and intervention group by odd and even grouping method,with 38 cases in each group. Patients in the control group were given traditional health education intervention, and the intervention group were given continuous care on WeChat platform on the basis of the control group. Three months after intervention, anxiety and depression scores, quality of life, self-management skills scores, and readmission rates were compared between the two groups. Results Three months after intervention, the scores of self-rating anxiety scale (SAS)and self-rating depression scale (SDS) in the intervention group were lower than those in the control group, and the differences were statistically significant (P＜0.05). The scores and total scores of all dimensions of inflammatory bowel disease questionnaire in the intervention group were higher than those in the control group, and the differences were statistically significant (P＜0.05). The scores and total scores of all dimensions of self-management ability in the intervention group were higher than those in the control group, and the differences were statistically significant (P＜0.05).The readmission rate in the intervention group was lower than that in the control group, and the difference was statistically significant (P＜0.05). Conclusion WeChat platform continuity nursing can improve the mental state and quality of life, and will enhance the level of patients′ self-management skills, and reduce the rate of readmission. 2022 Vol. 29 (15): 167-171 [Abstract] ( 29 ) HTML (1 KB)  PDF (647 KB)  ( 19 ) 172 Application effect of 5E rehabilitation treatment mode in patients with chronic kidney disease LIN Ling； LI Xuelian Objective To explore the effect of 5E rehabilitation treatment mode in patients with chronic kidney disease(CKD). Methods A total of 60 patients with CKD admitted to the Affiliated Hospital of North Sichuan Medical College from May 2020 to February 2021 were selected as the study subjects. The patients were divided into control group (30 cases) and experimental group (30 cases) by random number table method. Traditional nursing was used in the control group, and 5E rehabilitation was used in the experimental group. SF-36 score, daily water intake, daily dietary water content, daily dietary salt content, blood urea nitrogen, blood creatinine and cystatin C levels six months after discharge were compared between two groups before and after intervention. Results Before intervention, there was no significant difference in quality of life scores between the two groups (P＞0.05). After intervention, scores of quality of life in experimental group were higher than those in control group, the differences were statistically significant (P＜0.05). Before intervention, there were no significant differences in daily water intake, dietary water content and dietary salt content between two groups (P＞0.05). After intervention, the daily water intake, dietary water content and dietary salt content of experimental group were lower than those of control group, the differences were statistically significant (P＜0.05). Six months after discharge, the levels of blood urea nitrogen, serum creatinine and cystatin C in experimental group were lower than those in control group, the differences were statistically significant (P＜0.05). Conclusion Patients with CKD can not only improve the quality of life, but also reduce the daily water intake, dietary water content, dietary salt content and blood urea nitrogen, blood creatinine, cystatin C levels. 2022 Vol. 29 (15): 172-175 [Abstract] ( 21 ) HTML (1 KB)  PDF (648 KB)  ( 60 ) 176 Application effect of evidence-based nursing program in the prevention of catheter-related urinary tract infection ZHOU Ziqin Objective To explore the application effect of evidence-based nursing scheme in the prevention of catheter-related urinary tract infection. Methods A total of 100 patients with indwelling urethral catheter admitted to Huizhou Third People′s Hospital from January 2019 to September 2020 were selected as the study subjects. The patients were divided into control group (n=50) and experimental group (n=50) by random number table method. The control group was treated with conventional nursing program, and the experimental group was treated with evidence-based nursing program. The incidence of infection events, volume of first urination, time of first urination and nursing satisfaction were compared between the two groups. Results The incidence of infection in experimental group was 6.00%,which was lower than that in control group (22.00%), and the difference was statistically significant (P＜0.05). Nursing satisfaction of experimental group was higher than control group, the difference was statistically significant (P＜0.05).The volume of first urination in experimental group was more than that in control group, and the time of first urination was longer than that in control group, and the differences were statistically significant (P＜0.05). Conclusion In the nursing of patients with catheter-related urinary tract infection, evidence-based nursing is helpful to reduce the incidence of infection and improve patient satisfaction, which is worthy of further clinical discussion and application. 2022 Vol. 29 (15): 176-178 [Abstract] ( 23 ) HTML (1 KB)  PDF (656 KB)  ( 24 ) 179 Application of nursing intervention based on "doctor-patient shared decision-making" in preimplantation genetic diagnosis/screening of patients WU Jiaqi；TAN Ailing； FANG Xiaowu ；WEN Xiaojun； LYU Yanjun； FENG Guomei Objective To explore the effect of nursing intervention based on "doctor-patient shared decision-making(SDM)" in preimplantation genetic diagnosis/screening (PGD/PGS) patients. Methods A retrospective selection of 82 PGD/PGS patients admitted to Boai Hospital in Zhongshan City, Guangdong Province from January 2020 to June 2021 were selected as the research objects. According to the different nursing intervention methods, they were divided into the control group and the study group, with 41 cases in each group. The control group received routine nursing intervention, and the study group received “SDM” nursing intervention. The psychological status of patients before intervention and at the end of PGD/PGS (assessed with the self-rating depression scale [SDS] and self-rating anxiety scale[SAS]) were compared between the two groups, the decision-making participation satisfaction (using hospital self-made decision-making participation satisfaction degree questionnaire evaluation) was compared between the two groups. Results Before intervention, the SDS and SAS scores of the two groups were not statistically different (P＞0.05). At the end of PGD/PGS, the SDS and SAS scores of the study group were lower than those of the control group, and the differences were statistically significant (P＜0.05). The scores of the study group′s decision-making participation satisfaction questionnaire were higher than those of the control group, and the differences were statistically significant (t=7.020, P＜0.001). Conclusion Nursing intervention based on "SDM" can effectively improve the psychological status of PGD/PGS patients and increase their satisfaction with decision-making participation. 2022 Vol. 29 (15): 179-181转185 [Abstract] ( 25 ) HTML (1 KB)  PDF (691 KB)  ( 45 ) 182 Effect of four-hand nursing technology on the comfort of root canal treatment under oral microscope CHENG Chun； LIU Ying Objective To observe the effect of four-hand nursing technology on the comfort of root canal treatment under oral microscope. Methods A total of 90 patients receiving microscopic RCT from the First Affiliated Hospital/Affiliated Stomatological Hospital of Xinjiang Medical University, the Institute of Stomatology of Xinjiang Uygur Autonomous Region from January 2020 to June 2021 were selected into control group (45 cases)and observation group (45 cases).The control group received routine care cooperation and the observation group received four-hand nursing. RCT time, root tube filling quality, patient comfort (assessed by comfort status scale [GCQ]) and patient satisfaction with care (assessed by the self-made care satisfaction questionnaire) were compared between the two groups. Results The time of root canal preparation, root canal filling, root canal sealing and total treatment in the observation group were shorter than those in the control group, and the GCQ score and total score in the observation group were higher than those in the control group, with statistical significances (P＜0.05). There was no significant difference in the excellent and good rate of root canal filling between the two groups (P＞0.05). The total satisfaction of patients in the observation group was higher than that in the control group, and the difference was statistically significant (P＜0.05). Conclusion Four-hand nursing used in RCT patients under oral microscope can shorten RCT time and improve patient comfort and satisfaction. 2022 Vol. 29 (15): 182-185 [Abstract] ( 28 ) HTML (1 KB)  PDF (671 KB)  ( 71 ) 186 Application effect of comprehensive airway nursing combined with psychological nursing in non-invasive positive pressure ventilation in the treatment of chronic obstructive pulmonary disease with respiratory failure GU Xiaoli Objective To explore the application effect of omni-directional airway nursing combined with psychological nursing in non-invasive positive pressure ventilation for patients with chronic obstructive pulmonary disease combined with respiratory failure and its influence on patients′ nursing compliance, tension, anxiety and other negative emotions.Methods A total of 90 patients with COPD complicated with respiratory failure admitted to the First People′s Hospital of Yancheng City, Jiangsu Province from April 2020 to October 2021 were selected as the research objects, and they were divided into the conventional group and the combined group by random number table method, with 45 cases in each group. Patients in the conventional group were given psychological nursing alone, and patients in the combined group were given all-round airway nursing+psychological nursing. Lung ventilatory function indexes (total lung volume[TLC], forced vital capacity [FVC], maximum autonomous air volume [MVV]), Hamilton anxiety scale (HAMA), self-rating anxiety scale (SAS) score and good nursing compliance rate were compared between the two groups before and after nursing. Results After nursing, TLC, FVA and MVV levels in combined group were higher than those in control group,HAMA and SAS scores were lower than those in control group, and the excellent and good rate of nursing compliance(94.00% [47/50]) was higher than that in control group (75.00% [30/40]), the differences were statistically significant(P＜0.05). Conclusion Comprehensive airway nursing+psychological nursing has a positive impact on enhancing pulmonary ventilation function and improving the psychological state of patients with COPD combined with respiratory failure. Patients with higher nursing compliance after the combination of the two nursing programs, this nursing program has a high clinical application value. 2022 Vol. 29 (15): 186-189 [Abstract] ( 25 ) HTML (1 KB)  PDF (640 KB)  ( 35 ) 190 Application effect of pelvic floor muscle training in elderly parturient women WANG Qin Objective To explore the application effect of pelvic floor muscle training in elderly parturients. Methods A total of 58 cases of elderly parturitions in Jingzhou Second People′s Hospital from August 2018 to August 2020 were selected as the research objects. They were divided into observation group and control group by random number table method, with 29 cases in each group. The observation group received pelvic floor muscle training after delivery, while the control group only received routine nursing after delivery. The pelvic floor muscle strength, total recovery rate and sexual life quality were compared between the two groups. Results The pelvic floor muscle strength of the observation group was higher than that of the control group, and the difference was statistically significant (P＜0.05). The total effective rate of 89.66% in the observation group was higher than 65.52% in the control group, and the difference was statistically significant (P＜0.05). After intervention, the scores of sexual desire, sexual arousal, orgasm, sexual satisfaction and pain during intercourse in the observation group were higher than those before intervention, and the differences were statistically significant (P＜0.05). There was no statistically significant difference in the score of vaginal lubrication in the observation group before and after intervention (P＞0.05). In the control group, there were no significant differences in sexual desire, sexual arousal, vaginal lubrication, orgasm, satisfaction rate of sexual life and pain score before and after intervention (P＞0.05). After intervention, the scores of sexual desire, sexual arousal, sexual satisfaction and pain during intercourse in the observation group were higher than those in the control group, and the differences were statistically significant (P＜0.05). There were no statistically significant differences in vaginal lubrication and orgasm between the two groups (P＞0.05). Conclusion Pelvic floor muscle training can promote the recovery of pelvic floor function of elderly parturient women, improve the quality of postpartum sexual life, improve the quality of nursing, protect the health of elderly parturient women, and has high application value. 2022 Vol. 29 (15): 190-193 [Abstract] ( 26 ) HTML (1 KB)  PDF (638 KB)  ( 12 ) 194 Effect of different thermal insulation measures during anesthesia induction on perioperative body temperature of elderly patients undergoing gastrointestinal laparotomy TANG Guixiang ；HUANG Minrui； LUN Chuyi ；LI Yunjie Objective To investigate the effect of different thermal insulation measures during anesthesia induction on perioperative body temperature of elderly patients undergoing gastrointestinal laparotomy. Methods Eighty patients patients with gastrointestinal laparotomy treated in Yunfu People′s Hospital of Guangdong Province from January 2019 to December 2020 were selected as the research objects. They were randomly divided into control group and observation group, with 40 cases in each group. The control group was treated with routine thermal insulation measures, and the observation group was treated with comprehensive thermal insulation measures. The changes of body temperature and the total incidence of adverse reactions during anesthesia and after operation were compared and analyzed between the two groups. Results There was no significant difference in body temperature between the two groups before anesthesia(P＞0.05). The body temperature after operation in the observation group was lower than that in the control group, the difference was statistically significant (P＜0.05). The total incidence of adverse reactions in the observation group was lower than that in the control group, the difference was statistically significant (P＜0.05). Conclusion Comprehensive thermal insulation measures for elderly patients undergoing gastrointestinal laparotomy can not only reduce the patient′s body temperature, but also improve the safety of the operation to a certain extent. 2022 Vol. 29 (15): 194-196 [Abstract] ( 24 ) HTML (1 KB)  PDF (656 KB)  ( 23 )

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