血清铁蛋白、25-羟基维生素D、超敏C反应蛋白在妊娠早期检测对妊娠期糖尿病的预测价值

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Abstract Objective To determine the application value of serum ferritin (SF), 25- hydroxyvitamin D[25- (OH) D] and high sensitivity C reactive protein (hs-CRP) in the prediction of gestational diabetes mellitus (GDM) in early pregnancy.Methods The retrospective selection of 573 pregnant women who registered for the first visit in the obstetric clinic of Pudong New Area Maternal and Child Health hospital from January 2020 to December 2020 were selected as the research objects. All of them were tested for normal fasting blood glucose in the first trimester (12-16 weeks of gestation),and then passed the oral 75 g glucose tolerance test at 24-28 weeks of gestation. Parturients diagnosed with GDM were divided into observation group (273 cases), and non-GDM parturients were as the control group (300 cases). The levels of SF, 25-(OH)D, and hs-CRP in the two groups of parturients at 12-16 weeks of gestation were analyzed, and the effects of SF, 25-(OH)D, and hs-CRP on GDM were analyzed with logistic regression, and ROC curves were drawn. The predictive value of SF, 25-(OH)D, and hs-CRP was analyzed. Results There was no significant difference in fasting blood glucose (FPG) between the two groups (P＞0.05). SF and hs-CRP in the observation group were higher than those in the control group, while 25-(OH) D was lower than those in the control group, the differences were statistically significant (P＜0.05). Logistic regression analysis showed that SF and hs-CRP were risk factors for GDM (P＜0.05, OR＞1),and 25-(OH) D was protective factor (P＜0.05, OR＜1). The areas under the ROC curve of SF, 25-(OH) D and hs-CRP at 12-16 weeks of gestation were 0.730, 0.716 and 0.788, respectively, the sensitivity was 66.3%, 71.4% and 72.5%,and the specificity was 69.0%, 64.0% and 77.3%, respectively. The area under the curve of combined diagnosis of the SF, 25-(OH) D and hs-CRP was 0.818, the sensitivity was 71.1% and the specificity was 79.7%. Conclusion The combined detection of serum ferritin, 25-(OH) D and hs-CRP in early pregnancy has a certain predictive value for the occurrence of GDM, and has a certain positive significance for early detection, early prevention, glucose control for patients with GDM, and improvement of pregnancy outcome.

Key words： Gestational diabetes mellitus；25-hydroxyvitamin D；Serum ferritin；High-sensitivity C-reactive protein Combined detection

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	JIN Lianhua
	MA Ziwen
	SHEN Shuangyu
	ZHANG Baoren
	MAO Meili

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JIN Lianhua,MA Ziwen,SHEN Shuangyu, et al. Predictive value of serum ferritin, 25- hydroxyvitamin D and high sensitivity C reactive protein in early pregnancy for gestational diabetes mellitus[J]. 中国当代医药, 2022, 29(15): 19-22.

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https://www.dangdaiyiyao.com/EN/ OR https://www.dangdaiyiyao.com/EN/Y2022/V29/I15/19

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